BR112013018932A2 - polipeptídeo de interleucina-2 mutante, imunoconjugado, polinucleotídeo isolado, vetor de expressão, célula hospedeira, método de produção de um polipeptídeo de il-2 mutante ou um imunoconjugado do mesmo, composição farmacêutica, uso, método de tratamento de uma doença em um indivíduo e método de estimulação do sistema imunológico de um indivíduo - Google Patents
polipeptídeo de interleucina-2 mutante, imunoconjugado, polinucleotídeo isolado, vetor de expressão, célula hospedeira, método de produção de um polipeptídeo de il-2 mutante ou um imunoconjugado do mesmo, composição farmacêutica, uso, método de tratamento de uma doença em um indivíduo e método de estimulação do sistema imunológico de um indivíduoInfo
- Publication number
- BR112013018932A2 BR112013018932A2 BR112013018932A BR112013018932A BR112013018932A2 BR 112013018932 A2 BR112013018932 A2 BR 112013018932A2 BR 112013018932 A BR112013018932 A BR 112013018932A BR 112013018932 A BR112013018932 A BR 112013018932A BR 112013018932 A2 BR112013018932 A2 BR 112013018932A2
- Authority
- BR
- Brazil
- Prior art keywords
- immunoconjugate
- polypeptide
- individual
- mutant
- stimulating
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A61K38/2013—IL-2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
- A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
- A61K47/6813—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin the drug being a peptidic cytokine, e.g. an interleukin or interferon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6843—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
- A61K47/6853—Carcino-embryonic antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6871—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting an enzyme
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6891—Pre-targeting systems involving an antibody for targeting specific cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/55—IL-2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Cell Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Toxicology (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Mycology (AREA)
- Oncology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP11153964.9 | 2011-02-10 | ||
EP11153964 | 2011-02-10 | ||
EP11164237 | 2011-04-29 | ||
EP11164237.7 | 2011-04-29 | ||
PCT/EP2012/051991 WO2012107417A1 (en) | 2011-02-10 | 2012-02-07 | Mutant interleukin-2 polypeptides |
Publications (2)
Publication Number | Publication Date |
---|---|
BR112013018932A2 true BR112013018932A2 (pt) | 2017-05-02 |
BR112013018932B1 BR112013018932B1 (pt) | 2020-11-17 |
Family
ID=45560919
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112013018932-0A BR112013018932B1 (pt) | 2011-02-10 | 2012-02-07 | polipeptídeo de interleucina-2 (il-2) mutante, imunoconjugado, polinucleotídeo isolado, célula hospedeira de microrganismos, método de produção de um polipeptídeo de il-2 mutante, composição farmacêutica e usos do polipeptídeo de il-2 mutante ou do imunoconjugado |
Country Status (36)
Country | Link |
---|---|
US (5) | US9266938B2 (pt) |
EP (4) | EP2673294B1 (pt) |
JP (2) | JP5878182B2 (pt) |
KR (2) | KR101667096B1 (pt) |
CN (3) | CN112210000A (pt) |
AR (1) | AR085335A1 (pt) |
AU (2) | AU2012215573B2 (pt) |
BR (1) | BR112013018932B1 (pt) |
CA (1) | CA2824253C (pt) |
CL (1) | CL2013001987A1 (pt) |
CO (1) | CO6741186A2 (pt) |
CR (1) | CR20130314A (pt) |
CY (1) | CY1117842T1 (pt) |
DK (3) | DK3489255T3 (pt) |
EA (1) | EA033369B1 (pt) |
EC (1) | ECSP13012815A (pt) |
ES (3) | ES2579987T3 (pt) |
HK (1) | HK1217020A1 (pt) |
HR (3) | HRP20160917T1 (pt) |
HU (3) | HUE029139T2 (pt) |
IL (3) | IL269687B (pt) |
LT (2) | LT3075745T (pt) |
MA (1) | MA35803B1 (pt) |
MX (2) | MX340671B (pt) |
MY (1) | MY190604A (pt) |
PE (2) | PE20140303A1 (pt) |
PH (1) | PH12017500954A1 (pt) |
PL (3) | PL3075745T3 (pt) |
PT (3) | PT3075745T (pt) |
RS (3) | RS62238B1 (pt) |
SG (2) | SG10201604160WA (pt) |
SI (3) | SI3075745T1 (pt) |
TW (2) | TWI666027B (pt) |
UA (2) | UA117294C2 (pt) |
WO (1) | WO2012107417A1 (pt) |
ZA (1) | ZA201305282B (pt) |
Families Citing this family (242)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5992710A (ja) * | 1982-11-16 | 1984-05-29 | 関西電力株式会社 | 直接水冷線路の立坑部の布設方法 |
US9493578B2 (en) | 2009-09-02 | 2016-11-15 | Xencor, Inc. | Compositions and methods for simultaneous bivalent and monovalent co-engagement of antigens |
AU2011283694B2 (en) | 2010-07-29 | 2017-04-13 | Xencor, Inc. | Antibodies with modified isoelectric points |
NZ703653A (en) | 2010-08-13 | 2016-09-30 | Roche Glycart Ag | Anti-fap antibodies and methods of use |
UA117294C2 (uk) | 2011-02-10 | 2018-07-10 | Рош Глікарт Аг | Імунокон'югат |
KR101981342B1 (ko) * | 2011-03-02 | 2019-05-22 | 로슈 글리카트 아게 | Cea 항체 |
EA201892619A1 (ru) | 2011-04-29 | 2019-04-30 | Роше Гликарт Аг | Иммуноконъюгаты, содержащие мутантные полипептиды интерлейкина-2 |
JP6175428B2 (ja) | 2011-06-01 | 2017-08-02 | イントレクソン・アクトバイオテイクス・エヌブイIntrexon Actobiotics NV | 細菌のポリシストロン性発現系 |
WO2013026839A1 (en) | 2011-08-23 | 2013-02-28 | Roche Glycart Ag | Bispecific antibodies specific for t-cell activating antigens and a tumor antigen and methods of use |
US10851178B2 (en) | 2011-10-10 | 2020-12-01 | Xencor, Inc. | Heterodimeric human IgG1 polypeptides with isoelectric point modifications |
SG10201800535XA (en) * | 2012-08-07 | 2018-02-27 | Roche Glycart Ag | Composition comprising two antibodies engineered to have reduced and increased effector function |
US20140044675A1 (en) | 2012-08-10 | 2014-02-13 | Roche Glycart Ag | Interleukin-2 fusion proteins and uses thereof |
US10087250B2 (en) | 2012-10-08 | 2018-10-02 | Roche Glycart Ag | Fc-free antibodies comprising two fab-fragments and methods of use |
CN104781279A (zh) * | 2012-11-30 | 2015-07-15 | 罗切格利卡特公司 | 利用包含癌细胞靶向性mhc i类的多功能蛋白通过循环中的病毒特异性细胞毒性t细胞清除癌细胞 |
PL2935328T3 (pl) | 2012-12-21 | 2019-02-28 | Hoffmann La Roche | Połączone wiązaniem dwusiarczkowym wielowartościowe białka wielofunkcyjne zawierające MHC klasy I |
US9605084B2 (en) | 2013-03-15 | 2017-03-28 | Xencor, Inc. | Heterodimeric proteins |
EP3620473A1 (en) | 2013-01-14 | 2020-03-11 | Xencor, Inc. | Novel heterodimeric proteins |
US10487155B2 (en) | 2013-01-14 | 2019-11-26 | Xencor, Inc. | Heterodimeric proteins |
US9701759B2 (en) | 2013-01-14 | 2017-07-11 | Xencor, Inc. | Heterodimeric proteins |
US10968276B2 (en) | 2013-03-12 | 2021-04-06 | Xencor, Inc. | Optimized anti-CD3 variable regions |
US10131710B2 (en) | 2013-01-14 | 2018-11-20 | Xencor, Inc. | Optimized antibody variable regions |
US11053316B2 (en) | 2013-01-14 | 2021-07-06 | Xencor, Inc. | Optimized antibody variable regions |
US9738722B2 (en) | 2013-01-15 | 2017-08-22 | Xencor, Inc. | Rapid clearance of antigen complexes using novel antibodies |
KR102282761B1 (ko) * | 2013-02-26 | 2021-07-30 | 로슈 글리카트 아게 | 이중특이적 t 세포 활성화 항원 결합 분자 |
CA2896370A1 (en) | 2013-02-26 | 2014-09-04 | Roche Glycart Ag | Bispecific t cell activating antigen binding molecules |
US9580486B2 (en) * | 2013-03-14 | 2017-02-28 | Amgen Inc. | Interleukin-2 muteins for the expansion of T-regulatory cells |
US10106624B2 (en) | 2013-03-15 | 2018-10-23 | Xencor, Inc. | Heterodimeric proteins |
US10519242B2 (en) | 2013-03-15 | 2019-12-31 | Xencor, Inc. | Targeting regulatory T cells with heterodimeric proteins |
US10858417B2 (en) | 2013-03-15 | 2020-12-08 | Xencor, Inc. | Heterodimeric proteins |
EP2970486B1 (en) | 2013-03-15 | 2018-05-16 | Xencor, Inc. | Modulation of t cells with bispecific antibodies and fc fusions |
UA118028C2 (uk) | 2013-04-03 | 2018-11-12 | Рош Глікарт Аг | Біспецифічне антитіло, специфічне щодо fap і dr5, антитіло, специфічне щодо dr5, і спосіб їх застосування |
PT3041854T (pt) | 2013-08-08 | 2020-03-05 | Scripps Research Inst | Um método para a identificação enzimática específica ao local de ácidos nucleicos in vitro pela incorporação de nucleótidos não-naturais |
SI3102595T1 (sl) | 2014-02-06 | 2019-02-28 | F. Hoffmann-La Roche Ag | Fuzijske beljakovine z interlevkinom-2 in njihova uporaba |
GB201403775D0 (en) | 2014-03-04 | 2014-04-16 | Kymab Ltd | Antibodies, uses & methods |
US9822186B2 (en) | 2014-03-28 | 2017-11-21 | Xencor, Inc. | Bispecific antibodies that bind to CD38 and CD3 |
TWI638047B (zh) | 2014-04-09 | 2018-10-11 | 史基普研究協會 | 藉由核酸三磷酸酯轉運子將非天然或經修飾的核苷三磷酸酯輸入至細胞中 |
CN106604932A (zh) | 2014-07-10 | 2017-04-26 | 诺华公司 | 人白细胞介素‑2的免疫刺激单克隆抗体 |
IL289475B2 (en) * | 2014-07-21 | 2023-10-01 | Delinia Inc | Molecules that activate T cells are selectively regulated for the treatment of autoimmune diseases |
KR102317315B1 (ko) | 2014-08-04 | 2021-10-27 | 에프. 호프만-라 로슈 아게 | 이중특이적 t 세포 활성화 항원 결합 분자 |
EP3482766B1 (en) * | 2014-08-11 | 2020-05-20 | Delinia, Inc. | Modified il-2 variants that selectively activate regulatory t cells for the treatment of autoimmune diseases |
KR102058846B1 (ko) * | 2014-08-29 | 2020-02-20 | 에프. 호프만-라 로슈 아게 | 종양-표적 il-2 변이체 면역사이토카인 및 인간 pd-l1에 대한 항체의 조합 요법 |
CN113372434B (zh) | 2014-11-14 | 2024-06-04 | 豪夫迈·罗氏有限公司 | 包含tnf家族配体三聚体的抗原结合分子 |
SI3221357T1 (sl) | 2014-11-20 | 2020-09-30 | F. Hoffmann-La Roche Ag | Pogoste lahke verige in načini uporabe |
EP3789402B1 (en) | 2014-11-20 | 2022-07-13 | F. Hoffmann-La Roche AG | Combination therapy of t cell activating bispecific antigen binding molecules and pd-1 axis binding antagonists |
JP2017536830A (ja) | 2014-11-26 | 2017-12-14 | ゼンコー・インコーポレイテッドXencor、 Inc. | Cd3及びcd38に結合するヘテロ二量体抗体 |
EA201791139A1 (ru) | 2014-11-26 | 2018-04-30 | Ксенкор, Инк. | Гетеродимерные антитела, которые связывают cd3 и опухолевые антигены |
US10259887B2 (en) | 2014-11-26 | 2019-04-16 | Xencor, Inc. | Heterodimeric antibodies that bind CD3 and tumor antigens |
US10793613B2 (en) | 2014-12-15 | 2020-10-06 | Washington University | Compositions and methods for targeted cytokine delivery |
WO2016105450A2 (en) | 2014-12-22 | 2016-06-30 | Xencor, Inc. | Trispecific antibodies |
WO2016141387A1 (en) | 2015-03-05 | 2016-09-09 | Xencor, Inc. | Modulation of t cells with bispecific antibodies and fc fusions |
EP3277305B1 (en) | 2015-03-31 | 2021-07-21 | F. Hoffmann-La Roche AG | Antigen binding molecules comprising a trimeric tnf family ligand |
AR106188A1 (es) | 2015-10-01 | 2017-12-20 | Hoffmann La Roche | Anticuerpos anti-cd19 humano humanizados y métodos de utilización |
MA43017A (fr) | 2015-10-02 | 2018-08-08 | Hoffmann La Roche | Anticorps bispécifiques spécifiques d'un récepteur de co-stimulation du tnf |
JP7044700B2 (ja) | 2015-10-02 | 2022-03-30 | エフ・ホフマン-ラ・ロシュ・アクチェンゲゼルシャフト | 二重特異性抗ceaxcd3 t細胞活性化抗原結合分子 |
JP6622392B2 (ja) | 2015-10-02 | 2019-12-18 | エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト | Pd1とtim3に特異的な二重特異性抗体 |
WO2017077382A1 (en) | 2015-11-06 | 2017-05-11 | Orionis Biosciences Nv | Bi-functional chimeric proteins and uses thereof |
AU2016362777B2 (en) | 2015-12-04 | 2020-01-30 | Novartis Ag | Antibody cytokine engrafted compositions and methods of use for immunoregulation |
EP3387013B1 (en) | 2015-12-07 | 2022-06-08 | Xencor, Inc. | Heterodimeric antibodies that bind cd3 and psma |
IL313608A (en) | 2015-12-09 | 2024-08-01 | Hoffmann La Roche | Antibody against CD20 type II to reduce the formation of antibodies against drugs |
EP3178848A1 (en) | 2015-12-09 | 2017-06-14 | F. Hoffmann-La Roche AG | Type ii anti-cd20 antibody for reducing formation of anti-drug antibodies |
WO2017106767A1 (en) | 2015-12-18 | 2017-06-22 | The Scripps Research Institute | Production of unnatural nucleotides using a crispr/cas9 system |
MX2018008347A (es) | 2016-01-08 | 2018-12-06 | Hoffmann La Roche | Metodos de tratamiento de canceres positivos para ace utilizando antagonistas de union a eje pd-1 y anticuerpos biespecificos anti-ace/anti-cd3. |
CA3009001A1 (en) | 2016-01-11 | 2017-07-20 | Universitat Zurich | Immune-stimulating humanized monoclonal antibodies against human interleukin-2, and fusion proteins thereof |
DK3402499T3 (da) | 2016-01-14 | 2021-09-27 | Intrexon Actobiotics Nv | Sammensætninger og fremgangsmåder til behandlingen af type 1 diabetes |
US20170204154A1 (en) | 2016-01-20 | 2017-07-20 | Delinia, Inc. | Molecules that selectively activate regulatory t cells for the treatment of autoimmune diseases |
AU2017213659B2 (en) | 2016-02-05 | 2024-04-18 | Washington University | Compositions and methods for targeted cytokine delivery |
CN109071632B (zh) | 2016-02-05 | 2022-12-30 | 奥里尼斯生物科学私人有限公司 | 靶向性治疗剂及其用途 |
JP2019507762A (ja) | 2016-03-07 | 2019-03-22 | ブイアイビー ブイゼットダブリュー | Cd20結合単一ドメイン抗体 |
LT3433280T (lt) | 2016-03-22 | 2023-07-10 | F. Hoffmann-La Roche Ag | Proteazės aktyvuojamos t ląstelei bispecifinės molekulės |
WO2017194783A1 (en) | 2016-05-13 | 2017-11-16 | Orionis Biosciences Nv | Targeted mutant interferon-beta and uses thereof |
WO2017194782A2 (en) | 2016-05-13 | 2017-11-16 | Orionis Biosciences Nv | Therapeutic targeting of non-cellular structures |
RU2767357C2 (ru) | 2016-06-14 | 2022-03-17 | Ксенкор, Инк. | Биспецифические антитела-ингибиторы контрольных точек |
US9567399B1 (en) | 2016-06-20 | 2017-02-14 | Kymab Limited | Antibodies and immunocytokines |
WO2017220990A1 (en) | 2016-06-20 | 2017-12-28 | Kymab Limited | Anti-pd-l1 antibodies |
WO2017223528A1 (en) | 2016-06-24 | 2017-12-28 | The Scripps Research Institute | Novel nucleoside triphosphate transporter and uses thereof |
WO2018005706A1 (en) | 2016-06-28 | 2018-01-04 | Xencor, Inc. | Heterodimeric antibodies that bind somatostatin receptor 2 |
US10793632B2 (en) | 2016-08-30 | 2020-10-06 | Xencor, Inc. | Bispecific immunomodulatory antibodies that bind costimulatory and checkpoint receptors |
CN110087681A (zh) | 2016-09-28 | 2019-08-02 | 佐马美国有限公司 | 结合白细胞介素-2的抗体和其用途 |
EP3519437B1 (en) | 2016-09-30 | 2021-09-08 | F. Hoffmann-La Roche AG | Bispecific antibodies against p95her2 |
RU2019114175A (ru) | 2016-10-14 | 2020-11-16 | Ксенкор, Инк. | Биспецифические гетеродимерные слитые белки, содержащие fc-слитые белки il-15/il-15ra и фрагменты антитела к pd-1 |
JP7213180B2 (ja) * | 2016-10-19 | 2023-01-26 | エフ.ホフマン-ラ ロシュ アーゲー | 免疫コンジュゲートを製造するための方法 |
CN110114368B (zh) | 2016-10-24 | 2024-08-02 | 奥睿尼斯生物科学私人有限公司 | 靶向突变干扰素-γ及其用途 |
EP3534947A1 (en) | 2016-11-03 | 2019-09-11 | Kymab Limited | Antibodies, combinations comprising antibodies, biomarkers, uses & methods |
CN110167957A (zh) * | 2016-11-08 | 2019-08-23 | 德里尼亚公司 | 用于治疗自身免疫疾病的il-2变体 |
CU24483B1 (es) * | 2016-11-15 | 2020-04-02 | Ct Inmunologia Molecular | Método para incrementar los niveles de secreción de la interleucina-2 |
GB201621806D0 (en) | 2016-12-21 | 2017-02-01 | Philogen Spa | Immunocytokines with progressive activation mechanism |
SI3558339T1 (sl) * | 2016-12-22 | 2024-05-31 | Cue Biopharma, Inc. | Celico T modulirajoči multimerni polipeptidi in postopki njihove uporabe |
CN110546160A (zh) | 2017-02-06 | 2019-12-06 | 奥里尼斯生物科学公司 | 靶向嵌合蛋白及其用途 |
EP3576765A4 (en) | 2017-02-06 | 2020-12-02 | Orionis Biosciences, Inc. | TARGETED ENGINEERING INTERFERON AND USES OF IT |
US20200010528A1 (en) * | 2017-03-15 | 2020-01-09 | Cue Biopharma, Inc. | Methods for modulating an immune response |
WO2018170288A1 (en) | 2017-03-15 | 2018-09-20 | Pandion Therapeutics, Inc. | Targeted immunotolerance |
WO2018184965A1 (en) | 2017-04-03 | 2018-10-11 | F. Hoffmann-La Roche Ag | Immunoconjugates of il-2 with an anti-pd-1 and tim-3 bispecific antibody |
RS63663B1 (sr) | 2017-04-03 | 2022-11-30 | Hoffmann La Roche | Imunokonjugati anti-pd-1 antitela sa mutantom il-2 ili sa il-15 |
RU2766234C2 (ru) * | 2017-04-04 | 2022-02-10 | Ф. Хоффманн-Ля Рош Аг | Новые биспецифические антигенсвязывающие молекулы, обладающие способностью специфически связываться с cd40 и fap |
CA3052532A1 (en) | 2017-04-05 | 2018-10-11 | F. Hoffmann-La Roche Ag | Bispecific antibodies specifically binding to pd1 and lag3 |
EP3610006B1 (en) * | 2017-04-11 | 2021-05-19 | Roche Diagnostics GmbH | Mutant reverse transcriptase with increased thermal stability as well as products, methods and uses involving the same |
CN110505883A (zh) | 2017-04-13 | 2019-11-26 | 豪夫迈·罗氏有限公司 | 供治疗癌症的方法中使用的白介素-2免疫缀合物,cd40激动剂,和任选地pd-1轴结合拮抗剂 |
JOP20190271A1 (ar) | 2017-05-24 | 2019-11-21 | Novartis Ag | بروتينات مطعّمة بسيتوكين- الجسم المضاد وطرق الاستخدام للاضطرابات المتعلقة بالمناعة |
WO2018215936A1 (en) * | 2017-05-24 | 2018-11-29 | Novartis Ag | Antibody-cytokine engrafted proteins and methods of use in the treatment of cancer |
CN111010866A (zh) | 2017-05-24 | 2020-04-14 | 潘迪恩治疗公司 | 靶向免疫耐受性 |
EP3630162A1 (en) * | 2017-05-24 | 2020-04-08 | Novartis AG | Antibody-cytokine engrafted proteins and methods of use |
WO2019006472A1 (en) | 2017-06-30 | 2019-01-03 | Xencor, Inc. | TARGETED HETETRODIMERIC FUSION PROTEINS CONTAINING IL-15 / IL-15RA AND ANTIGEN-BINDING DOMAINS |
WO2019014267A1 (en) | 2017-07-11 | 2019-01-17 | Synthorx, Inc. | INCORPORATION OF NON-NATURAL NUCLEOTIDES AND ASSOCIATED METHODS |
AU2018309172B2 (en) | 2017-08-03 | 2022-12-15 | Synthorx, Inc. | Cytokine conjugates for the treatment of autoimmune diseases |
CA3082383A1 (en) | 2017-11-08 | 2019-05-16 | Xencor, Inc. | Bispecific and monospecific antibodies using novel anti-pd-1 sequences |
US10981992B2 (en) | 2017-11-08 | 2021-04-20 | Xencor, Inc. | Bispecific immunomodulatory antibodies that bind costimulatory and checkpoint receptors |
AU2018372167B2 (en) | 2017-11-21 | 2023-12-07 | The Board Of Trustees Of The Leland Stanford Junior University | Partial agonists of interleukin-2 |
US10946068B2 (en) | 2017-12-06 | 2021-03-16 | Pandion Operations, Inc. | IL-2 muteins and uses thereof |
US10174092B1 (en) | 2017-12-06 | 2019-01-08 | Pandion Therapeutics, Inc. | IL-2 muteins |
MX2020006322A (es) | 2017-12-19 | 2020-09-18 | Xencor Inc | Proteinas de fusion il-2 fc modificadas. |
EP3733716A4 (en) * | 2017-12-26 | 2021-11-24 | Nanjing GenScript Biotech Co., Ltd. | DIMERAL FUSION PROTEIN USING ANTIBODY FC REGION AS A SKELETON AND ASSOCIATED USE |
KR20200128533A (ko) | 2018-02-05 | 2020-11-13 | 오리오니스 바이오사이언시즈 인코포레이티드 | 섬유아세포 결합제 및 이의 용도 |
MX2020008289A (es) | 2018-02-08 | 2020-09-25 | Genentech Inc | Moleculas biespecificas de union al antigeno y metodos de uso. |
JP7515412B2 (ja) * | 2018-03-09 | 2024-07-12 | アスクジーン・ファーマ・インコーポレイテッド | 新規のサイトカインプロドラッグ |
CA3094112A1 (en) * | 2018-03-28 | 2019-10-03 | Bristol-Myers Squibb Company | Interleukin-2/interleukin-2 receptor alpha fusion proteins and methods of use |
MX2020009857A (es) * | 2018-03-28 | 2021-01-08 | Ascendis Pharma Oncology Div A/S | Conjugados de interleucina-2 (il-2). |
EP3773911A2 (en) | 2018-04-04 | 2021-02-17 | Xencor, Inc. | Heterodimeric antibodies that bind fibroblast activation protein |
JP2021520829A (ja) | 2018-04-18 | 2021-08-26 | ゼンコア インコーポレイテッド | IL−15/IL−15RA Fc融合タンパク質およびTIM−3抗原結合ドメインを含む、TIM−3標的化ヘテロ二量体融合タンパク質 |
MX2020010910A (es) | 2018-04-18 | 2021-02-09 | Xencor Inc | Proteinas de fusion heterodimericas dirigidas a pd-1 que contienen proteinas de fusion il-15 / il-15ra fc y dominios de union al antigeno pd-1 y usos de los mismos. |
DE202019005887U1 (de) | 2018-07-03 | 2023-06-14 | Marengo Therapeutics, Inc. | Anti-TCR-Antikörpermoleküle und Verwendungen davon |
JP7550745B2 (ja) * | 2018-07-24 | 2024-09-13 | バイオエヌテック エスエー | Il2アゴニスト |
EP3829605A4 (en) * | 2018-08-01 | 2022-10-19 | ImmunityBio, Inc. | QUADRICISTRONIC SYSTEM WITH A HOMING RECEPTOR OR A CYTOKINE AND A CHIMERIC ANTIGEN RECEPTOR FOR GENETIC MODIFICATION OF IMMUNOTHERAPIES |
DK3849614T3 (da) * | 2018-09-11 | 2024-02-26 | Ambrx Inc | Interleukin-2-polypeptidkonjugater og anvendelser deraf |
WO2020060122A1 (ko) | 2018-09-17 | 2020-03-26 | (주)지아이이노베이션 | Il-2 단백질 및 cd80 단백질을 포함하는 융합단백질 및 이의 용도 |
AR114732A1 (es) | 2018-09-18 | 2020-10-07 | Hoffmann La Roche | Utilización de un inhibidor de catepsina s contra la formación de anticuerpos antifármaco |
JP7512210B2 (ja) * | 2018-09-21 | 2024-07-08 | イノベント バイオロジックス (スウツォウ) カンパニー,リミテッド | 新規インターロイキン2およびその使用 |
JP2022501009A (ja) * | 2018-09-21 | 2022-01-06 | イノベント バイオロジックス (スウツォウ) カンパニー,リミテッド | 新規インターロイキン2およびその使用 |
BR112021005907A2 (pt) * | 2018-09-27 | 2021-08-10 | Xilio Development, Inc. | citocinas mascaradas, ácido nucleico, vetor, célula hospedeira, métodos para produzir uma citocina mascarada, para tratar ou prevenir uma doença neoplásica e para tratar ou prevenir uma doença inflamatória ou autoimune neoplásica, composição, composição farmacêutica e kit |
US11358999B2 (en) | 2018-10-03 | 2022-06-14 | Xencor, Inc. | IL-12 heterodimeric Fc-fusion proteins |
JP2022505871A (ja) * | 2018-10-23 | 2022-01-14 | ドラゴンフライ セラピューティクス, インコーポレイテッド | ヘテロ二量体fc融合タンパク質 |
MX2021004916A (es) * | 2018-10-29 | 2021-06-18 | 1Globe Biomedical Co Ltd | Nuevas composiciones proteicas de diseño idóneo. |
TW202034945A (zh) * | 2018-12-21 | 2020-10-01 | 大陸商江蘇恆瑞醫藥股份有限公司 | 一種人白細胞介素2變體或其衍生物 |
SG11202105093RA (en) | 2018-12-21 | 2021-06-29 | Hoffmann La Roche | Tumor-targeted agonistic cd28 antigen binding molecules |
WO2020127369A1 (en) | 2018-12-21 | 2020-06-25 | Ose Immunotherapeutics | Bifunctional molecule directed against human pd-1 |
KR20200078312A (ko) * | 2018-12-21 | 2020-07-01 | 한미약품 주식회사 | 신규 면역 억제 인터루킨 2 (Interleukin 2) 아날로그 |
AU2020206672A1 (en) * | 2019-01-07 | 2021-07-15 | Inhibrx Biosciences, Inc. | Polypeptides comprising modified IL-2 polypeptides and uses thereof |
WO2020148612A1 (en) * | 2019-01-14 | 2020-07-23 | Ignite Immunotherapy, Inc. | Recombinant vaccinia virus and methods of use thereof |
EP3923974A4 (en) | 2019-02-06 | 2023-02-08 | Synthorx, Inc. | IL-2 CONJUGATES AND METHODS OF USE THEREOF |
EP3930850A1 (en) | 2019-03-01 | 2022-01-05 | Xencor, Inc. | Heterodimeric antibodies that bind enpp3 and cd3 |
CN111647068A (zh) * | 2019-03-04 | 2020-09-11 | 江苏恒瑞医药股份有限公司 | 一种人白细胞介素2变体或其衍生物 |
CN111944008A (zh) * | 2019-05-14 | 2020-11-17 | 上海盖浦生物科技有限公司 | 一种突变蛋白的方法以及得到的突变体蛋白 |
CN111944036B (zh) * | 2019-05-14 | 2024-09-06 | 上海盖浦生物科技有限公司 | 一种增殖免疫细胞的突变体蛋白 |
WO2020234387A1 (en) | 2019-05-20 | 2020-11-26 | Cytune Pharma | IL-2/IL-15Rßy AGONIST DOSING REGIMENS FOR TREATING CANCER OR INFECTIOUS DISEASES |
JP2022533702A (ja) | 2019-05-20 | 2022-07-25 | パンディオン・オペレーションズ・インコーポレイテッド | MAdCAM標的化免疫寛容 |
CA3141626A1 (en) | 2019-06-12 | 2020-12-17 | AskGene Pharma, Inc. | Novel il-15 prodrugs and methods of use thereof |
KR20220035122A (ko) * | 2019-06-14 | 2022-03-21 | 큐진 인크. | 신규한 인터루킨-2 변이체 및 이의 이작용성 융합 분자 |
BR112021025130A2 (pt) | 2019-06-14 | 2022-03-15 | Scripps Research Inst | Reagentes e métodos para replicação, transcrição e tradução em organismos semissintéticos |
TW202115105A (zh) * | 2019-06-24 | 2021-04-16 | 德商拜恩迪克Rna製藥有限公司 | Il2激動劑 |
EP3994169A1 (en) | 2019-07-02 | 2022-05-11 | F. Hoffmann-La Roche AG | Immunoconjugates comprising a mutant interleukin-2 and an anti-cd8 antibody |
BR112022001415A2 (pt) | 2019-07-26 | 2022-06-07 | Visterra Inc | Agentes interleucina-2 e os usos dos mesmos |
WO2021030483A1 (en) * | 2019-08-12 | 2021-02-18 | AskGene Pharma, Inc. | Il-2 fusion proteins that preferentially bind il-2ralpha |
US20230203119A1 (en) | 2019-08-15 | 2023-06-29 | Igm Biosciences, Inc. | Immunostimulatory multimeric binding molecules |
WO2021055568A1 (en) * | 2019-09-19 | 2021-03-25 | Proviva Therapeutics (Hong Kong) Limited | Il-2 compositions and methods of use thereof |
US20220340621A1 (en) | 2019-09-27 | 2022-10-27 | Intrexon Actobiotics Nv D/B/A Precigen Actobio | Treatment of celiac disease |
BR112022008129A2 (pt) | 2019-11-20 | 2022-08-23 | Gi Cell Inc | Composição da cultura de células t reguladoras e uso da mesma |
WO2021101271A1 (ko) | 2019-11-20 | 2021-05-27 | 주식회사 지아이셀 | T 세포 배양용 배지 조성물 및 이를 이용한 t 세포의 배양 방법 |
JP7381750B2 (ja) | 2019-11-20 | 2023-11-15 | ジーアイ・セル・インコーポレイテッド | ナチュラルキラー細胞培養用組成物及びこれを用いたナチュラルキラー細胞の製造方法 |
BR112022010246A2 (pt) | 2019-11-27 | 2022-09-06 | Gi Innovation Inc | Composição farmacêutica para o tratamento de câncer compreendendo proteína de fusão compreendendo proteína il-2 e proteína cd80 e inibidor de checkpoint imunológico |
JP7488337B2 (ja) | 2019-11-27 | 2024-05-21 | ジーアイ・セル・インコーポレイテッド | Il-2タンパク質及びcd80タンパク質を含む融合タンパク質及びnk細胞を含む抗癌治療用組成物 |
KR20220114595A (ko) | 2019-12-17 | 2022-08-17 | 암젠 인크 | 치료에서의 사용을 위한 이중 인터류킨-2/tnf 수용체 효현제 |
CN114524873A (zh) * | 2019-12-17 | 2022-05-24 | 北京志道生物科技有限公司 | 白介素-2衍生物 |
JP2023510115A (ja) | 2019-12-20 | 2023-03-13 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | 新規il2アゴニストおよびそれらの使用方法 |
CN115175690A (zh) * | 2020-01-09 | 2022-10-11 | 辉瑞大药厂 | 重组牛痘病毒 |
EP4087865A2 (en) | 2020-01-10 | 2022-11-16 | Bright Peak Therapeutics AG | Modified il-2 polypeptides and uses thereof |
MX2022008772A (es) | 2020-01-14 | 2022-10-07 | Synthekine Inc | Ortologos de il2 y metodos de uso. |
JP7303391B2 (ja) | 2020-01-14 | 2023-07-04 | シンセカイン インコーポレイテッド | バイアス型il2ムテイン、方法、および組成物 |
US11230699B2 (en) | 2020-01-28 | 2022-01-25 | Immunitybio, Inc. | Chimeric antigen receptor-modified NK-92 cells targeting EGFR super-family receptors |
WO2021168079A1 (en) | 2020-02-21 | 2021-08-26 | Pandion Operations, Inc. | Tissue targeted immunotolerance with a cd39 effector |
TWI839476B (zh) * | 2020-02-26 | 2024-04-21 | 大陸商北京泰德製藥股份有限公司 | 介白素-2多肽共軛物及其用途 |
MX2022011154A (es) | 2020-03-18 | 2022-10-13 | Gi Innovation Inc | Composicion farmaceutica para el tratamiento de cancer que comprende proteina de fusion que se compone de proteina il-2 y proteina cd80 y farmaco anticancerigeno. |
EP4122447A4 (en) | 2020-03-18 | 2023-11-01 | GI Innovation, Inc. | PREPARATION OF FUSION PROTEIN COMPRISING IL-2 AND CD80 PROTEINS |
US20230139890A1 (en) | 2020-03-18 | 2023-05-04 | Gi Innovation, Inc. | Fusion protein comprising il-2 protein and cd80 protein fragment or variant thereof, and uses thereof |
WO2021185362A1 (zh) | 2020-03-19 | 2021-09-23 | 信达生物制药(苏州)有限公司 | 白介素2突变体及其用途 |
EP4122952A4 (en) * | 2020-03-19 | 2024-05-29 | Innovent Biologics (Singapore) Pte. Ltd. | INTERLEUKIN-2 MUTANT AND ITS USE |
AU2021245922A1 (en) * | 2020-04-01 | 2022-10-13 | Xilio Development, Inc. | Masked IL-2 cytokines and their cleavage products |
WO2021209402A2 (en) | 2020-04-15 | 2021-10-21 | F. Hoffmann-La Roche Ag | Immunoconjugates |
CA3168737A1 (en) | 2020-04-21 | 2021-10-28 | Jiaxi WU | Il-2 variants with reduced binding to il-2 receptor alpha and uses thereof |
CN115916811A (zh) | 2020-04-22 | 2023-04-04 | 默沙东有限责任公司 | 偏向于白介素-2受体βγc二聚体并缀合非肽水溶性聚合物的人白介素-2缀合物 |
AU2021272340A1 (en) | 2020-05-11 | 2022-12-08 | F. Hoffmann-La Roche Ag | Combination therapy with modified pbmcs and an immunoconjugate |
WO2021231773A1 (en) | 2020-05-13 | 2021-11-18 | Good Therapeutics, Inc. | Compositions of protein complexes and methods of use thereof |
US11919956B2 (en) | 2020-05-14 | 2024-03-05 | Xencor, Inc. | Heterodimeric antibodies that bind prostate specific membrane antigen (PSMA) and CD3 |
BR112022022826A2 (pt) | 2020-06-03 | 2022-12-13 | Ascendis Pharma Oncology Div A/S | Sequências de il-2 e usos das mesmas |
KR102373965B1 (ko) | 2020-06-05 | 2022-03-15 | (주)지아이이노베이션 | Il-2 단백질 및 cd80 단백질을 포함하는 융합단백질을 포함하는 방사선 치료 증진용 약학적 조성물 |
CR20220637A (es) | 2020-06-19 | 2023-01-31 | Hoffmann La Roche | Anticuerpos que se unen a cd3 y cd19 |
CN115916827A (zh) | 2020-06-19 | 2023-04-04 | 豪夫迈·罗氏有限公司 | 免疫活化Fc结构域结合分子 |
CN115916831A (zh) | 2020-06-30 | 2023-04-04 | Gi 医诺微新 | 包含抗lag-3抗体和il-2的融合蛋白及其用途 |
KR20220014531A (ko) * | 2020-07-29 | 2022-02-07 | (주)메디톡스 | 헤테로이량체 Fc 융합 단백질, 및 관련 조성물, 용도 및 방법 |
TW202221031A (zh) | 2020-07-30 | 2022-06-01 | 英商阿法克塔生命科學有限公司 | 血清半衰期延長之pd-l1抑制多肽 |
MX2023001962A (es) | 2020-08-19 | 2023-04-26 | Xencor Inc | Composiciones anti-cd28. |
EP4211149A4 (en) | 2020-09-09 | 2024-10-09 | Cue Biopharma Inc | MHC CLASS II T-CELL MODULATING MULTIMER POLYPEPTIDES FOR THE TREATMENT OF TYPE 1 DIABETES MELLITUS (T1D) AND METHODS OF USE THEREOF |
WO2022059794A1 (ja) * | 2020-09-18 | 2022-03-24 | 地方独立行政法人 宮城県立病院機構 | Il-2変異体タンパク質及びこれを含む医薬 |
CN118598977A (zh) * | 2020-10-18 | 2024-09-06 | 北京志道生物科技有限公司 | 经修饰的il-2分子及其用途 |
CN114369153A (zh) * | 2020-10-18 | 2022-04-19 | 北京志道生物科技有限公司 | 一种白介素-2突变体 |
TWI815194B (zh) | 2020-10-22 | 2023-09-11 | 美商基利科學股份有限公司 | 介白素2-Fc融合蛋白及使用方法 |
WO2022090203A1 (en) | 2020-10-26 | 2022-05-05 | Cytune Pharma | IL-2/IL-15Rβү AGONIST FOR TREATING SQUAMOUS CELL CARCINOMA |
EP4232068A1 (en) | 2020-10-26 | 2023-08-30 | Cytune Pharma | IL-2/IL-15RBetaGamma AGONIST FOR TREATING NON-MELANOMA SKIN CANCER |
EP4236962A1 (en) | 2020-10-29 | 2023-09-06 | Bristol-Myers Squibb Company | Fusion proteins for the treatment of disease |
CN114437228B (zh) * | 2020-10-30 | 2024-02-06 | 中国科学院生物物理研究所 | 一种il-2与抗体亚单位构成的双功能融合蛋白 |
US20230398183A1 (en) | 2020-11-13 | 2023-12-14 | Jiangsu Hengrui Pharmaceuticals Co., Ltd. | Pharmaceutical composition comprising human interleukin 2 variant or derivative thereof and use thereof |
CN112724259B (zh) * | 2020-11-16 | 2022-12-20 | 天津林达生物科技有限公司 | 人血清白蛋白与白介素2的融合蛋白及其用途 |
JP2023551563A (ja) | 2020-12-04 | 2023-12-08 | エフ・ホフマン-ラ・ロシュ・アクチェンゲゼルシャフト | pH依存性変異体インターロイキン-2ポリペプチド |
JP2024502708A (ja) | 2020-12-04 | 2024-01-23 | ビステラ, インコーポレイテッド | インターロイキン-2作用物質を使用する方法 |
WO2022148853A1 (en) | 2021-01-11 | 2022-07-14 | F. Hoffmann-La Roche Ag | Immunoconjugates |
CA3207261A1 (en) * | 2021-01-19 | 2022-07-28 | Seneca Therapeutics, Inc. | Armed seneca valley virus oncolytic therapy compositions and methods thereof |
AU2022232375A1 (en) | 2021-03-09 | 2023-09-21 | Xencor, Inc. | Heterodimeric antibodies that bind cd3 and cldn6 |
EP4304724A1 (en) | 2021-03-09 | 2024-01-17 | F. Hoffmann-La Roche AG | Combination therapy of pd-1-targeted il-2 variant immunoconjugate and anti-tyrp1/anti-cd3 bispecific antibodies |
KR20230156051A (ko) | 2021-03-09 | 2023-11-13 | 에프. 호프만-라 로슈 아게 | Pd-1-표적화 il-2 변이체 면역접합체 및 fap/4-1bb 결합 분자의 병용 요법 |
EP4305065A1 (en) | 2021-03-10 | 2024-01-17 | Xencor, Inc. | Heterodimeric antibodies that bind cd3 and gpc3 |
MX2023011310A (es) | 2021-03-26 | 2023-10-05 | Innate Pharma | Anclajes de citocina para proteinas de celulas nk de union a nkp46. |
EP4314032A1 (en) | 2021-03-30 | 2024-02-07 | F. Hoffmann-La Roche AG | Protease-activated polypeptides |
US20240182571A1 (en) | 2021-04-09 | 2024-06-06 | Ose Immunotherapeutics | New scaffold for bifunctional molecules with improved properties |
CN113321722A (zh) * | 2021-04-13 | 2021-08-31 | 苏州复融生物技术有限公司 | 白介素2突变体及其应用 |
MX2023014647A (es) | 2021-06-09 | 2024-01-31 | Innate Pharma | Proteinas de union a nkp46 multiespecificas. |
WO2022258678A1 (en) | 2021-06-09 | 2022-12-15 | Innate Pharma | Multispecific proteins binding to nkp30, a cytokine receptor, a tumour antigen and cd16a |
IL308531A (en) | 2021-06-09 | 2024-01-01 | Innate Pharma | Multiple specific antibodies that bind to CD20, NKP46, CD16 and are equipped with IL-2 |
WO2022258691A1 (en) | 2021-06-09 | 2022-12-15 | Innate Pharma | Multispecific proteins binding to nkg2d, a cytokine receptor, a tumour antigen and cd16a |
WO2022266467A2 (en) | 2021-06-17 | 2022-12-22 | Dana-Farber Cancer Institute, Inc. | Recombinant histone polypeptide and uses thereof |
AU2022306788A1 (en) | 2021-07-09 | 2024-01-04 | Bright Peak Therapeutics Ag | Conjugates of checkpoint inhibitors with il-2, and uses thereof |
WO2023281481A1 (en) | 2021-07-09 | 2023-01-12 | Bright Peak Therapeutics | Antibody conjugates and manufacture thereof |
KR20240041379A (ko) | 2021-07-09 | 2024-03-29 | 브라이트 피크 테라퓨틱스 아게 | Il-2에 접합된 체크포인트 억제제 및 이의 용도 |
US20230201365A1 (en) | 2021-07-09 | 2023-06-29 | Bright Peak Therapeutics Ag | Modified cd20 antibodies and uses thereof |
WO2023017191A1 (en) | 2021-08-13 | 2023-02-16 | Cytune Pharma | Il-2/il-15rbetagamma agonist combination with antibody-drug conjugates for treating cancer |
MX2024002261A (es) | 2021-08-24 | 2024-03-06 | Jiangsu Hengrui Pharmaceuticals Co Ltd | Molecula de union de fap/cd40 y uso medicinal de la misma. |
KR20240067081A (ko) * | 2021-09-26 | 2024-05-16 | 우시 바이올로직스 아일랜드 리미티드 | Il-2 변이체 및 이의 융합 단백질 |
KR20240082349A (ko) | 2021-10-14 | 2024-06-10 | 에프. 호프만-라 로슈 아게 | 새로운 인터루킨-7 면역접합체 |
EP4429706A1 (en) | 2021-10-14 | 2024-09-18 | F. Hoffmann-La Roche AG | Alternative pd1-il7v immunoconjugates for the treatment of cancer |
CU20210104A7 (es) | 2021-12-21 | 2023-07-12 | Ct Inmunologia Molecular | Proteínas de fusión compuestas por un anticuerpo y una muteína agonista de interleucina 2 |
KR20230095612A (ko) * | 2021-12-22 | 2023-06-29 | 한미약품 주식회사 | 신규 면역 억제 인터루킨 2 (Interleukin 2) 아날로그 |
WO2023133595A2 (en) | 2022-01-10 | 2023-07-13 | Sana Biotechnology, Inc. | Methods of ex vivo dosing and administration of lipid particles or viral vectors and related systems and uses |
US20230303650A1 (en) * | 2022-01-21 | 2023-09-28 | Aetio Biotherapy, Inc. | Immunoconjugates of Interlukin-2 Mutant Polypeptides with Antibodies |
WO2023161857A1 (en) | 2022-02-23 | 2023-08-31 | Bright Peak Therapeutics Ag | Bifunctional cytokine compositions |
WO2023193015A1 (en) | 2022-04-01 | 2023-10-05 | Sana Biotechnology, Inc. | Cytokine receptor agonist and viral vector combination therapies |
US20240076343A1 (en) | 2022-06-16 | 2024-03-07 | Cephalon Llc | Anti-pd-1 antibody-attenuated il-2 immunoconjugates and uses thereof |
TW202409069A (zh) * | 2022-07-01 | 2024-03-01 | 大陸商北京星奇原生物科技有限公司 | Il-2多肽和使用方法 |
US11773160B1 (en) | 2022-08-05 | 2023-10-03 | Anaveon AG | Immune-stimulating IL-2 fusion proteins |
TW202413398A (zh) * | 2022-08-16 | 2024-04-01 | 國立陽明交通大學 | 介白素-2變異體及其於治療癌症的用途 |
WO2024068705A1 (en) | 2022-09-29 | 2024-04-04 | F. Hoffmann-La Roche Ag | Protease-activated polypeptides |
CN116041539B (zh) * | 2022-10-31 | 2023-07-21 | 山东博安生物技术股份有限公司 | Il-2突变体免疫缀合物 |
WO2024119193A2 (en) | 2022-12-02 | 2024-06-06 | AskGene Pharma, Inc. | Mutant il-2 polypeptides and il-2 prodrugs |
WO2024150175A1 (en) | 2023-01-11 | 2024-07-18 | Bright Peak Therapeutics Ag | Conditionally activated proteins and methods of use |
WO2024150174A1 (en) | 2023-01-11 | 2024-07-18 | Bright Peak Therapeutics Ag | Conditionally activated immunocytokines and methods of use |
WO2024153722A1 (en) | 2023-01-20 | 2024-07-25 | F. Hoffmann-La Roche Ag | Immunoconjugates |
Family Cites Families (85)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2388385B1 (fr) | 1977-04-18 | 1982-01-08 | Hitachi Metals Ltd | Piece d'ornement fixee par des aimants permanents |
US4518584A (en) | 1983-04-15 | 1985-05-21 | Cetus Corporation | Human recombinant interleukin-2 muteins |
US4604377A (en) | 1984-03-28 | 1986-08-05 | Cetus Corporation | Pharmaceutical compositions of microbially produced interleukin-2 |
US5116943A (en) | 1985-01-18 | 1992-05-26 | Cetus Corporation | Oxidation-resistant muteins of Il-2 and other protein |
US5206344A (en) | 1985-06-26 | 1993-04-27 | Cetus Oncology Corporation | Interleukin-2 muteins and polymer conjugation thereof |
US4766106A (en) | 1985-06-26 | 1988-08-23 | Cetus Corporation | Solubilization of proteins for pharmaceutical compositions using polymer conjugation |
WO1987000056A1 (en) | 1985-06-26 | 1987-01-15 | Cetus Corporation | Solubilization of proteins for pharmaceutical compositions using polymer conjugation |
US6548640B1 (en) | 1986-03-27 | 2003-04-15 | Btg International Limited | Altered antibodies |
JP3101690B2 (ja) | 1987-03-18 | 2000-10-23 | エス・ビィ・2・インコーポレイテッド | 変性抗体の、または変性抗体に関する改良 |
DE3920358A1 (de) | 1989-06-22 | 1991-01-17 | Behringwerke Ag | Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung |
US5959177A (en) | 1989-10-27 | 1999-09-28 | The Scripps Research Institute | Transgenic plants expressing assembled secretory antibodies |
GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
US5571894A (en) | 1991-02-05 | 1996-11-05 | Ciba-Geigy Corporation | Recombinant antibodies specific for a growth factor receptor |
LU91067I2 (fr) | 1991-06-14 | 2004-04-02 | Genentech Inc | Trastuzumab et ses variantes et dérivés immuno chimiques y compris les immotoxines |
GB9114948D0 (en) | 1991-07-11 | 1991-08-28 | Pfizer Ltd | Process for preparing sertraline intermediates |
ES2136092T3 (es) | 1991-09-23 | 1999-11-16 | Medical Res Council | Procedimientos para la produccion de anticuerpos humanizados. |
US5587458A (en) | 1991-10-07 | 1996-12-24 | Aronex Pharmaceuticals, Inc. | Anti-erbB-2 antibodies, combinations thereof, and therapeutic and diagnostic uses thereof |
CA2372813A1 (en) | 1992-02-06 | 1993-08-19 | L.L. Houston | Biosynthetic binding protein for cancer marker |
US5229109A (en) | 1992-04-14 | 1993-07-20 | Board Of Regents, The University Of Texas System | Low toxicity interleukin-2 analogues for use in immunotherapy |
US5731168A (en) | 1995-03-01 | 1998-03-24 | Genentech, Inc. | Method for making heteromultimeric polypeptides |
US5869046A (en) | 1995-04-14 | 1999-02-09 | Genentech, Inc. | Altered polypeptides with increased half-life |
DE19607751A1 (de) | 1996-02-29 | 1997-09-04 | Henkel Kgaa | Neue Aminophenol-Derivate und deren Verwendung |
JP2001504326A (ja) | 1996-10-18 | 2001-04-03 | ジェネンテック インコーポレーテッド | 抗ErbB2抗体 |
US6040498A (en) | 1998-08-11 | 2000-03-21 | North Caroline State University | Genetically engineered duckweed |
DK1034298T3 (da) | 1997-12-05 | 2012-01-30 | Scripps Research Inst | Humanisering af murint antistof |
DK1068241T3 (da) | 1998-04-02 | 2008-02-04 | Genentech Inc | Antistofvarianter og fragmenter deraf |
AU3657899A (en) | 1998-04-20 | 1999-11-08 | James E. Bailey | Glycosylation engineering of antibodies for improving antibody-dependent cellular cytotoxicity |
US20030175884A1 (en) | 2001-08-03 | 2003-09-18 | Pablo Umana | Antibody glycosylation variants having increased antibody-dependent cellular cytotoxicity |
US6455677B1 (en) | 1998-04-30 | 2002-09-24 | Boehringer Ingelheim International Gmbh | FAPα-specific antibody with improved producibility |
EP0953639A1 (en) | 1998-04-30 | 1999-11-03 | Boehringer Ingelheim International GmbH | FAPalpha-specific antibody with improved producibility |
DZ2788A1 (fr) | 1998-05-15 | 2003-12-01 | Bayer Ag | Agonistes et antagonistes selectifs à IL-2. |
US6955807B1 (en) * | 1998-05-15 | 2005-10-18 | Bayer Pharmaceuticals Corporation | IL-2 selective agonists and antagonists |
RU2236251C2 (ru) | 1999-02-12 | 2004-09-20 | Дзе Скриппс Рисерч Инститьют | Способы лечения опухолей и метастазов с использованием комбинации антиангиогенной терапии и иммунотерапии |
NZ517906A (en) | 1999-10-04 | 2003-01-31 | Medicago Inc | Cloning of genomic sequences encoding nitrite reductase (NiR) for use in regulated expression of foreign genes in host plants |
US7125978B1 (en) | 1999-10-04 | 2006-10-24 | Medicago Inc. | Promoter for regulating expression of foreign genes |
WO2001068708A2 (en) | 2000-03-17 | 2001-09-20 | Boehringer Ingelheim Pharma Kg | Human and humanized fap-alpha-specific antibodies |
JP4936299B2 (ja) | 2000-08-21 | 2012-05-23 | メレクシス・テクノロジーズ・ナムローゼフェンノートシャップ | 磁場方向検出センサ |
US7396917B2 (en) | 2000-12-05 | 2008-07-08 | Alexion Pharmaceuticals, Inc. | Rationally designed antibodies |
KR100927670B1 (ko) | 2001-04-13 | 2009-11-20 | 바이오겐 아이덱 엠에이 인코포레이티드 | Vla-1에 대한 항체들 |
AU2002355955A1 (en) | 2001-08-13 | 2003-03-03 | University Of Southern California | Interleukin-2 mutants with reduced toxicity |
WO2003048334A2 (en) * | 2001-12-04 | 2003-06-12 | Merck Patent Gmbh | Immunocytokines with modulated selectivity |
US7432063B2 (en) | 2002-02-14 | 2008-10-07 | Kalobios Pharmaceuticals, Inc. | Methods for affinity maturation |
ATE471946T1 (de) * | 2002-12-17 | 2010-07-15 | Merck Patent Gmbh | Humanisierter antikörper (h14.18) des maus antikörpers 14.18, der gd2 bindet und seine fusion mit il-2 |
ES2542885T3 (es) | 2003-01-22 | 2015-08-12 | Roche Glycart Ag | Constructos de fusión y uso de los mismos para producir anticuerpos con mayor afinidad de unión al receptor de Fc y función efectora |
TWI353991B (en) | 2003-05-06 | 2011-12-11 | Syntonix Pharmaceuticals Inc | Immunoglobulin chimeric monomer-dimer hybrids |
WO2005062929A2 (en) | 2003-12-22 | 2005-07-14 | Chiron Coporation | Use of fc receptor polymorphisms as diagnostics for treatment strategies for immune-response disorders |
KR20070003934A (ko) * | 2004-03-05 | 2007-01-05 | 노바티스 백신즈 앤드 다이아그노스틱스 인코포레이티드 | 치료제의 환자 내약성을 예측하기 위한 시험관 내 테스트시스템 |
CN1930300A (zh) * | 2004-03-05 | 2007-03-14 | 希龙公司 | 预测患者治疗药物耐受性的体外试验系统 |
WO2005097832A2 (en) | 2004-03-31 | 2005-10-20 | Genentech, Inc. | Humanized anti-tgf-beta antibodies |
US8455625B2 (en) | 2005-05-11 | 2013-06-04 | Philogen S.P.A. | Fusion protein of antibody L19 against fibronectin ED-B and interleukin 12 |
EP1806365A1 (en) | 2006-01-05 | 2007-07-11 | Boehringer Ingelheim International GmbH | Antibody molecules specific for fibroblast activation protein and immunoconjugates containing them |
EP2016098B1 (en) | 2006-05-08 | 2016-09-07 | Philogen S.p.A. | Antibody-targeted cytokines for therapy |
WO2008003473A2 (en) * | 2006-07-06 | 2008-01-10 | Merck Patent Gmbh | Compositions and methods for enhancing the efficacy of il-2 mediated immune responses |
AR062223A1 (es) | 2006-08-09 | 2008-10-22 | Glycart Biotechnology Ag | Moleculas de adhesion al antigeno que se adhieren a egfr, vectores que los codifican, y sus usos de estas |
PL2066796T3 (pl) | 2006-09-20 | 2011-11-30 | Mt Biomethan Gmbh | Sposób i urządzenie do separacji metanu i dwutlenku węgla z biogazu |
EP2120998B1 (en) | 2006-11-28 | 2013-08-07 | HanAll Biopharma Co., Ltd. | Modified erythropoietin polypeptides and uses thereof for treatment |
WO2009126558A1 (en) | 2008-04-10 | 2009-10-15 | Ibc Pharmaceuticals, Inc. | Modular method to prepare tetrameric cytokines with improved pharmacokinetics by the dock-and-lock (dnl) technology |
BRPI0811857A2 (pt) * | 2007-05-14 | 2014-10-21 | Biogen Idec Inc | Regiões fc (scfc) de cadeia simples, polipeptídeos de aglutinação que as compreendem e métodos relacionados. |
US8119130B2 (en) | 2007-07-25 | 2012-02-21 | Medimmune Limited | Targeted binding agents directed to KDR and uses thereof—035 |
EP2018877A1 (en) | 2007-07-27 | 2009-01-28 | The Procter and Gamble Company | Absorbent article comprising water-absorbing polymeric particles and method for the production thereof |
US8906356B2 (en) | 2007-11-05 | 2014-12-09 | Massachusetts Institute Of Technology | Mutant interleukin-2 (IL-2) polypeptides |
CN101970730A (zh) | 2007-12-19 | 2011-02-09 | 森托科尔奥索生物科技公司 | 通过融合到pⅨ或pⅦ来设计和生成人从头pⅨ噬菌体展示文库,载体、抗体及方法 |
HUE028536T2 (en) | 2008-01-07 | 2016-12-28 | Amgen Inc | Method for producing antibody to FC heterodimer molecules using electrostatic control effects |
ATE548052T1 (de) | 2008-01-17 | 2012-03-15 | Philogen Spa | Kombination aus einem anti-edb-fibronectin- antikörper-il-2-fusionsprotein und einem b-zellen bindenden molekül, b-zellen-vorläufern und/oder deren krebserregendem gegenspieler |
CA2723823C (en) | 2008-05-13 | 2012-10-16 | Molmed S.P.A. | Conjugates for the treatment of mesothelioma |
CA2749539C (en) * | 2009-01-21 | 2022-07-19 | Amgen Inc. | Compositions and methods comprising interleukin-2 mutants for treating inflammatory and autoimmune diseases |
WO2010088444A1 (en) | 2009-01-29 | 2010-08-05 | Medimmune, Llc | Human anti-il-6 antibodies with extended in vivo half-life and their use in treatment of oncology, autoimmune diseases and inflammatory diseases |
CA2756393C (en) * | 2009-03-24 | 2017-06-20 | The Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services | Anti-mesothelin antibodies |
WO2010117448A2 (en) | 2009-04-05 | 2010-10-14 | Provenance Biopharmaceuticals Corp. | Chimeric immunocytokines and methods of use thereof |
US20120107270A1 (en) | 2009-06-30 | 2012-05-03 | Manuela Kaspar | Immunocytokines In Combination With Anti-ErbB Antibodies For The Treatment Of Cancer |
WO2011020783A2 (en) | 2009-08-17 | 2011-02-24 | Roche Glycart Ag | Targeted immunoconjugates |
KR101528013B1 (ko) | 2009-08-31 | 2015-06-16 | 로슈 글리카트 아게 | 친화성-성숙된 인간화된 항-cea 단일클론 항체 |
DK2483310T3 (da) | 2009-09-29 | 2014-09-01 | Roche Glycart Ag | Bispecifik dødsreceptor-agonistiske antistoffer |
NZ703653A (en) | 2010-08-13 | 2016-09-30 | Roche Glycart Ag | Anti-fap antibodies and methods of use |
CU23923B1 (es) | 2010-11-12 | 2013-07-31 | Ct De Inmunología Molecular | Polipéptidos derivados de la il-2 con actividad agonista |
UA117294C2 (uk) | 2011-02-10 | 2018-07-10 | Рош Глікарт Аг | Імунокон'югат |
KR101981342B1 (ko) | 2011-03-02 | 2019-05-22 | 로슈 글리카트 아게 | Cea 항체 |
ES2692268T3 (es) | 2011-03-29 | 2018-12-03 | Roche Glycart Ag | Variantes de Fc de anticuerpo |
EA201892619A1 (ru) | 2011-04-29 | 2019-04-30 | Роше Гликарт Аг | Иммуноконъюгаты, содержащие мутантные полипептиды интерлейкина-2 |
SG10201800535XA (en) | 2012-08-07 | 2018-02-27 | Roche Glycart Ag | Composition comprising two antibodies engineered to have reduced and increased effector function |
WO2014023673A1 (en) | 2012-08-08 | 2014-02-13 | Roche Glycart Ag | Interleukin-10 fusion proteins and uses thereof |
US20140044675A1 (en) | 2012-08-10 | 2014-02-13 | Roche Glycart Ag | Interleukin-2 fusion proteins and uses thereof |
UA118028C2 (uk) | 2013-04-03 | 2018-11-12 | Рош Глікарт Аг | Біспецифічне антитіло, специфічне щодо fap і dr5, антитіло, специфічне щодо dr5, і спосіб їх застосування |
MX2015014538A (es) | 2013-05-07 | 2016-02-05 | Hoffmann La Roche | Moleculas de union a antigenos trimericas. |
KR102058846B1 (ko) | 2014-08-29 | 2020-02-20 | 에프. 호프만-라 로슈 아게 | 종양-표적 il-2 변이체 면역사이토카인 및 인간 pd-l1에 대한 항체의 조합 요법 |
-
2012
- 2012-02-07 UA UAA201611547A patent/UA117294C2/uk unknown
- 2012-02-07 US US13/367,843 patent/US9266938B2/en active Active
- 2012-02-07 SI SI201231430T patent/SI3075745T1/sl unknown
- 2012-02-07 PT PT16164244T patent/PT3075745T/pt unknown
- 2012-02-07 EP EP12702045.1A patent/EP2673294B1/en active Active
- 2012-02-07 WO PCT/EP2012/051991 patent/WO2012107417A1/en active Application Filing
- 2012-02-07 ES ES12702045.1T patent/ES2579987T3/es active Active
- 2012-02-07 HU HUE12702045A patent/HUE029139T2/hu unknown
- 2012-02-07 PL PL16164244T patent/PL3075745T3/pl unknown
- 2012-02-07 PE PE2013001855A patent/PE20140303A1/es active IP Right Grant
- 2012-02-07 RS RS20210996A patent/RS62238B1/sr unknown
- 2012-02-07 CN CN202010954354.5A patent/CN112210000A/zh active Pending
- 2012-02-07 DK DK18191941.6T patent/DK3489255T3/da active
- 2012-02-07 SI SI201230620A patent/SI2673294T1/sl unknown
- 2012-02-07 SG SG10201604160WA patent/SG10201604160WA/en unknown
- 2012-02-07 MX MX2013009226A patent/MX340671B/es active IP Right Grant
- 2012-02-07 CA CA2824253A patent/CA2824253C/en active Active
- 2012-02-07 JP JP2013552930A patent/JP5878182B2/ja active Active
- 2012-02-07 BR BR112013018932-0A patent/BR112013018932B1/pt active IP Right Grant
- 2012-02-07 PL PL18191941T patent/PL3489255T3/pl unknown
- 2012-02-07 TW TW106101987A patent/TWI666027B/zh not_active IP Right Cessation
- 2012-02-07 MX MX2016006214A patent/MX356675B/es unknown
- 2012-02-07 DK DK16164244.2T patent/DK3075745T3/en active
- 2012-02-07 UA UAA201310726A patent/UA113729C2/uk unknown
- 2012-02-07 LT LTEP16164244.2T patent/LT3075745T/lt unknown
- 2012-02-07 LT LTEP18191941.6T patent/LT3489255T/lt unknown
- 2012-02-07 HU HUE16164244A patent/HUE040326T2/hu unknown
- 2012-02-07 PT PT181919416T patent/PT3489255T/pt unknown
- 2012-02-07 MY MYPI2013701387A patent/MY190604A/en unknown
- 2012-02-07 SI SI201231940T patent/SI3489255T1/sl unknown
- 2012-02-07 TW TW101103928A patent/TWI577801B/zh active
- 2012-02-07 CN CN201510970941.2A patent/CN105440123B/zh active Active
- 2012-02-07 IL IL269687A patent/IL269687B/en unknown
- 2012-02-07 ES ES18191941T patent/ES2883371T3/es active Active
- 2012-02-07 PT PT127020451T patent/PT2673294T/pt unknown
- 2012-02-07 SG SG2013060207A patent/SG192673A1/en unknown
- 2012-02-07 EA EA201300896A patent/EA033369B1/ru not_active IP Right Cessation
- 2012-02-07 EP EP18191941.6A patent/EP3489255B1/en active Active
- 2012-02-07 CN CN201280017730.1A patent/CN103492411B/zh active Active
- 2012-02-07 RS RS20160397A patent/RS54802B1/sr unknown
- 2012-02-07 EP EP16164244.2A patent/EP3075745B1/en active Active
- 2012-02-07 KR KR1020137020938A patent/KR101667096B1/ko active IP Right Grant
- 2012-02-07 EP EP21178401.2A patent/EP3971206A1/en not_active Withdrawn
- 2012-02-07 PE PE2018000181A patent/PE20181077A1/es unknown
- 2012-02-07 KR KR1020157020539A patent/KR101852245B1/ko active IP Right Grant
- 2012-02-07 RS RS20181250A patent/RS57767B1/sr unknown
- 2012-02-07 PL PL12702045.1T patent/PL2673294T3/pl unknown
- 2012-02-07 HU HUE18191941A patent/HUE055284T2/hu unknown
- 2012-02-07 DK DK12702045.1T patent/DK2673294T3/en active
- 2012-02-07 ES ES16164244.2T patent/ES2694564T3/es active Active
- 2012-02-07 AU AU2012215573A patent/AU2012215573B2/en active Active
- 2012-02-08 AR ARP120100412A patent/AR085335A1/es active IP Right Grant
-
2013
- 2013-06-20 IL IL227095A patent/IL227095B/en active IP Right Grant
- 2013-06-24 CR CR20130314A patent/CR20130314A/es unknown
- 2013-06-25 CO CO13150839A patent/CO6741186A2/es unknown
- 2013-07-05 CL CL2013001987A patent/CL2013001987A1/es unknown
- 2013-07-12 ZA ZA2013/05282A patent/ZA201305282B/en unknown
- 2013-08-09 EC ECSP13012815 patent/ECSP13012815A/es unknown
- 2013-09-10 MA MA36237A patent/MA35803B1/fr unknown
-
2014
- 2014-03-27 HK HK16105003.6A patent/HK1217020A1/zh unknown
-
2015
- 2015-05-20 JP JP2015102866A patent/JP6155300B2/ja not_active Expired - Fee Related
- 2015-10-28 AU AU2015249085A patent/AU2015249085B2/en not_active Ceased
-
2016
- 2016-01-15 US US14/996,789 patent/US10323098B2/en active Active
- 2016-07-21 CY CY20161100718T patent/CY1117842T1/el unknown
- 2016-07-21 HR HRP20160917TT patent/HRP20160917T1/hr unknown
-
2017
- 2017-05-11 IL IL25223017A patent/IL252230B/en active IP Right Grant
- 2017-05-24 PH PH12017500954A patent/PH12017500954A1/en unknown
- 2017-12-20 US US15/849,501 patent/US10184009B2/en active Active
-
2018
- 2018-10-22 HR HRP20181736TT patent/HRP20181736T1/hr unknown
- 2018-11-21 US US16/198,531 patent/US11111312B2/en active Active
-
2019
- 2019-06-17 US US16/443,306 patent/US20190322765A1/en not_active Abandoned
-
2021
- 2021-08-16 HR HRP20211318TT patent/HRP20211318T1/hr unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BR112013018932A2 (pt) | polipeptídeo de interleucina-2 mutante, imunoconjugado, polinucleotídeo isolado, vetor de expressão, célula hospedeira, método de produção de um polipeptídeo de il-2 mutante ou um imunoconjugado do mesmo, composição farmacêutica, uso, método de tratamento de uma doença em um indivíduo e método de estimulação do sistema imunológico de um indivíduo | |
TN2012000335A1 (en) | Antibody formulation and therapeutic regimens | |
BR112012013868A8 (pt) | composição, proteína de fusão, polinucleotídeo, vetor ou constructo de gene, célula hospedeira , composição farmacêutica, método in vitro e uso de uma composição. | |
NZ599792A (en) | Immunomodulatory polypeptides derived from il- 2 and their use thereof in the therapeutic of cancer and chronic infections | |
EP4382164A3 (en) | Methods for treating or preventing asthma by administering an il-4r antagonist | |
WO2014145159A3 (en) | Charge-engineered antibodies or compositions of penetration-enhanced targeting proteins and methods of use | |
FR2962437B1 (fr) | Derives d'imidazopyridine, leur procede de preparation et leur application en therapeutique | |
BR112013003361A2 (pt) | anticorpo, polinucleotídeo e polipeptídeo isolado, composição, vetor, célual hospedeira, método de produção de um anticorpo, conjugado de anticorpo, formulação farmacêutica, uso do anticorpo, métodos de tratamento, de indução e de diagnóstico de doença em um indivíduo | |
SG178991A1 (en) | Anti-gitr antibodies | |
EP4353254A3 (en) | Methods for treating skin infection by administering an il-4r antagonist | |
EA202090662A3 (ru) | ПРОИЗВОДНЫЕ ПИРРОЛО[3,2-d]ПИРИМИДИНА ДЛЯ ЛЕЧЕНИЯ ВИРУСНЫХ ИНФЕКЦИЙ И ДРУГИХ ЗАБОЛЕВАНИЙ | |
BR112014026990A2 (pt) | anticorpo , ácido nucleico , vetores , célula hospedeira , composição farmacêutica , uso de um anticorpo e método para o tratamento de um paciente com necessidade de terapia. | |
BRPI1006215A2 (pt) | " anticorpos multiespecíficos, ácido nucleico, célula hospedeira, método de produção de um anticorpo, imunoconjugado, formulação farmacêutica, método de tratamento, método de inibição de uma atividade bíologica e uso do anticorpo " | |
BRPI0906997A2 (pt) | Proteína, uso da proteína combinante ou fragmento da mesma, método para induzir uma resposta imune em um individuo, método para tratar um paceinte, construção de ácido nicleico, vetor de ezpressão o ucélula hospedeira, vacina, anticorpo, e, composição farmaceutica | |
MX366130B (es) | Inhibidores bivalentes de las proteinas iap y métodos terapéuticos que usan los mismos. | |
TN2012000414A1 (en) | Forms of rifaximin and uses thereof | |
BR112013030963A2 (pt) | proteína de fusão, polinucleotídio, constructo, vetor, célula hospedeira ou organismo, composição farmacêutica ou vacina, uso da proteína de fusão, método para prevenir ou tratar infecção hev ou doenças associadas com infecção hev, método para prevenir ou tratar infecção do vírus influenza e doenças associadas com a infecção do vírus influenza, método para melhorar a imunogenicidade de uma proteína alvo e uso de crm197 ou um fragmento do mesmo | |
FR2967674B1 (fr) | Derives d'heteroarylsulfonamides, leur preparation et leur application en therapeutique humaine | |
BR112013030396A2 (pt) | polipeptídeo, polinucleotídeo, vetor, célula hospedeira, composição imunogênica, vacina, e, uso de uma composição imunogênica ou de uma vacina | |
FR2974576B1 (fr) | Derives de n-[(1h-pyrazol-1-yl)aryl]-1h-indole ou 1h- indazole-3-carboxamide, leur preparation et leurs applications en therapeutique | |
MX2014004814A (es) | Compuestos y metodos para mejorar las respuestas inmunes innatas. | |
BR112012026174A2 (pt) | anticorpo isolado, ácido nucleico isolado, vetor, célula hospedeira, método de produção de um anticorpo, imunoconjugado, formulação farmacêutica, doença ou disfunção, uso do anticorpo, método de tratamento, de determinação e de separação | |
WO2012145238A3 (en) | Methods for reducing an adverse immune response to a foreign antigen in human using cd4-binding molecules | |
EP4349864A3 (en) | Oncostatin m receptor antigen binding proteins | |
BR112014027981A2 (pt) | compostos do tipo fumagilol e métodos de produção e utilização dos mesmos |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
B15K | Others concerning applications: alteration of classification |
Ipc: C07K 16/40 (2006.01), A61K 38/20 (2006.01), A61K 4 |
|
B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] |
Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI |
|
B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
B09X | Republication of the decision to grant [chapter 9.1.3 patent gazette] | ||
B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 07/02/2012, OBSERVADAS AS CONDICOES LEGAIS. |