BR112013030396A2 - polipeptídeo, polinucleotídeo, vetor, célula hospedeira, composição imunogênica, vacina, e, uso de uma composição imunogênica ou de uma vacina - Google Patents

polipeptídeo, polinucleotídeo, vetor, célula hospedeira, composição imunogênica, vacina, e, uso de uma composição imunogênica ou de uma vacina

Info

Publication number
BR112013030396A2
BR112013030396A2 BR112013030396A BR112013030396A BR112013030396A2 BR 112013030396 A2 BR112013030396 A2 BR 112013030396A2 BR 112013030396 A BR112013030396 A BR 112013030396A BR 112013030396 A BR112013030396 A BR 112013030396A BR 112013030396 A2 BR112013030396 A2 BR 112013030396A2
Authority
BR
Brazil
Prior art keywords
vaccine
immunogenic composition
polynucleotide
polypeptide
vector
Prior art date
Application number
BR112013030396A
Other languages
English (en)
Inventor
Cindy Castado
Original Assignee
Glaxosmithkline Biolog Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=46168484&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR112013030396(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Glaxosmithkline Biolog Sa filed Critical Glaxosmithkline Biolog Sa
Publication of BR112013030396A2 publication Critical patent/BR112013030396A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/08—Clostridium, e.g. Clostridium tetani
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/33—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Clostridium (G)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1267—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria
    • C07K16/1282—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria from Clostridium (G)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A61K2039/575—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 humoral response
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/55—Fusion polypeptide containing a fusion with a toxin, e.g. diphteria toxin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
BR112013030396A 2011-05-27 2012-05-25 polipeptídeo, polinucleotídeo, vetor, célula hospedeira, composição imunogênica, vacina, e, uso de uma composição imunogênica ou de uma vacina BR112013030396A2 (pt)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201161490734P 2011-05-27 2011-05-27
US201161490716P 2011-05-27 2011-05-27
US201161490707P 2011-05-27 2011-05-27
PCT/EP2012/059793 WO2012163811A1 (en) 2011-05-27 2012-05-25 Immunogenic composition

Publications (1)

Publication Number Publication Date
BR112013030396A2 true BR112013030396A2 (pt) 2016-12-13

Family

ID=46168484

Family Applications (2)

Application Number Title Priority Date Filing Date
BR112013030396A BR112013030396A2 (pt) 2011-05-27 2012-05-25 polipeptídeo, polinucleotídeo, vetor, célula hospedeira, composição imunogênica, vacina, e, uso de uma composição imunogênica ou de uma vacina
BR112013030395-6A BR112013030395B1 (pt) 2011-05-27 2012-05-25 Polipeptídeo, composição imunogênica, vacina, e, uso de uma composição imunogênica ou de uma vacina.

Family Applications After (1)

Application Number Title Priority Date Filing Date
BR112013030395-6A BR112013030395B1 (pt) 2011-05-27 2012-05-25 Polipeptídeo, composição imunogênica, vacina, e, uso de uma composição imunogênica ou de uma vacina.

Country Status (25)

Country Link
US (5) US9290565B2 (pt)
EP (6) EP4296361A3 (pt)
JP (3) JP5952390B2 (pt)
KR (1) KR102014502B1 (pt)
CN (3) CN103732750A (pt)
BR (2) BR112013030396A2 (pt)
CA (2) CA2837395C (pt)
CY (3) CY1118599T1 (pt)
DK (4) DK3564378T5 (pt)
EA (1) EA030898B1 (pt)
ES (4) ES2968455T3 (pt)
FI (1) FI3564378T3 (pt)
HR (4) HRP20231749T1 (pt)
HU (4) HUE037126T2 (pt)
IL (1) IL229529B2 (pt)
LT (4) LT3564378T (pt)
ME (1) ME02600B (pt)
MX (1) MX346200B (pt)
PL (4) PL3138916T3 (pt)
PT (4) PT2714911T (pt)
RS (1) RS55605B1 (pt)
SG (1) SG195037A1 (pt)
SI (4) SI3138916T1 (pt)
SM (1) SMT201700110B (pt)
WO (3) WO2012163817A2 (pt)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LT2753352T (lt) 2010-09-03 2017-05-25 Valneva Austria Gmbh Išskirtas toksino a ir toksino b baltymų polipeptidas iš c. difficile ir jo panaudojimas
EP4365196A3 (en) 2011-04-22 2024-08-07 Wyeth LLC Compositions relating to a mutant clostridium difficile toxin and methods thereof
JP6084631B2 (ja) * 2011-12-08 2017-02-22 ノバルティス アーゲー Ｃｌｏｓｔｒｉｄｉｕｍｄｉｆｆｉｃｉｌｅ毒素ベースのワクチン
BR122016023101B1 (pt) 2012-10-21 2022-03-22 Pfizer Inc Polipeptídeo, composição imunogênica que o compreende, bem como célula recombinante derivada de clostridium difficile
DK2928489T3 (en) 2012-12-05 2019-04-23 Glaxosmithkline Biologicals Sa IMMUNOGENE COMPOSITION
EP2988778A4 (en) * 2013-04-22 2016-12-14 Board Of Regents Of The Univ Of Oklahoma CLOSTRIDIUM DIFFICILE IMPREGENT AND METHOD OF USE
US10533036B2 (en) 2015-02-19 2020-01-14 Immune Biosolutions Inc Clostridium difficile toxins a and/or B antigen and epitope antibody, and pharmaceutical uses thereof
CN112703006A (zh) * 2018-06-19 2021-04-23 葛兰素史密丝克莱恩生物有限公司 免疫原性组合物
WO2023020992A1 (en) 2021-08-16 2023-02-23 Glaxosmithkline Biologicals Sa Novel methods
WO2023020993A1 (en) 2021-08-16 2023-02-23 Glaxosmithkline Biologicals Sa Novel methods
WO2023020994A1 (en) 2021-08-16 2023-02-23 Glaxosmithkline Biologicals Sa Novel methods
GB202205833D0 (en) 2022-04-21 2022-06-08 Glaxosmithkline Biologicals Sa Bacteriophage
WO2023232901A1 (en) 2022-06-01 2023-12-07 Valneva Austria Gmbh Clostridium difficile vaccine
WO2024160901A1 (en) 2023-02-02 2024-08-08 Glaxosmithkline Biologicals Sa Immunogenic composition

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4235877A (en) 1979-06-27 1980-11-25 Merck & Co., Inc. Liposome particle containing viral or bacterial antigenic subunit
US4751180A (en) 1985-03-28 1988-06-14 Chiron Corporation Expression using fused genes providing for protein product
US4935233A (en) 1985-12-02 1990-06-19 G. D. Searle And Company Covalently linked polypeptide cell modulators
BR9509903A (pt) * 1994-10-24 1997-11-25 Ophidian Pharm Inc Proteína de fusão proteína de fus o solúvel composição de matéria célula hospedeira processo para gerar uma antiotoxina neutralizante dirigida contra toxina tipo a de clostridium botulinum anticorpo processo para purificar uma proteina de fusão recombinante derivada de uma toxina tipo a de clostridium botulinum processo para gerar uma antitoxina neutralizante dirigida contra toxina tipo b de clostridium difficile anticorpo processo de tratemento processo para gerar uma antitoxina neutralizante dirigida contra toxina tipo a de clostridium difficile composição processo para vacinar um individuo para produzir antitoxina neutralizante dirigida contra toxina de clostridium difficile processo a detecção de antigenos de clostridium difficile em uma amosta processo de purificação de toxinas de clostridium difficile de uma cultura e processo de generação de uma forma dosagem sólida de uma antitoxina de ave dirigida contra uma proteina de toxina clostridial
DE69610106D1 (de) * 1995-07-07 2000-10-05 Oravax Inc Toxine und toxoide von clostridium difficile als schleimhautadjuvans
EP2502998A3 (en) * 1999-04-09 2013-02-27 Intercell USA, Inc. Recombinant toxin A/ToxinB vaccine against clostridium difficile
AU781027B2 (en) 1999-04-09 2005-04-28 Department Of Health & Human Services Recombinant toxin a protein carrier for polysaccharide conjugate vaccines
AU2001251013A1 (en) 2000-03-28 2001-10-08 Diadexus, Inc. Compositions and methods of diagnosing, monitoring, staging, imaging and treating colon cancer
EP2318515A4 (en) * 2008-08-06 2012-11-14 Emergent Product Dev Uk Ltd DIFFICULT CLOSTRIDIUM VACCINES, AND METHODS OF USE
US10046040B2 (en) 2009-11-16 2018-08-14 University Of Maryland, Baltimore Multivalent live vector vaccine against Clostridium difficile-associated disease
LT2753352T (lt) 2010-09-03 2017-05-25 Valneva Austria Gmbh Išskirtas toksino a ir toksino b baltymų polipeptidas iš c. difficile ir jo panaudojimas
GB201016742D0 (en) * 2010-10-05 2010-11-17 Health Prot Agency Clostridium difficile antigens

Also Published As

Publication number Publication date
US20140093529A1 (en) 2014-04-03
US9290565B2 (en) 2016-03-22
LT3564378T (lt) 2024-01-25
PT3138916T (pt) 2019-09-17
RS55605B1 (sr) 2017-06-30
DK2714910T3 (en) 2018-02-05
EP2714911B1 (en) 2016-11-30
CY1119916T1 (el) 2018-06-27
KR20140019848A (ko) 2014-02-17
CA2837395A1 (en) 2012-12-06
SI2714910T1 (en) 2018-04-30
EP2714911A2 (en) 2014-04-09
CA2837395C (en) 2021-05-18
JP2014522238A (ja) 2014-09-04
KR102014502B1 (ko) 2019-08-26
EP2714910A1 (en) 2014-04-09
JP5952390B2 (ja) 2016-07-13
EP3138916A1 (en) 2017-03-08
IL229529B2 (en) 2023-05-01
ES2743442T3 (es) 2020-02-19
WO2012163817A2 (en) 2012-12-06
ES2968455T3 (es) 2024-05-09
PL2714910T3 (pl) 2018-06-29
DK2714911T3 (en) 2017-02-27
ES2660468T3 (es) 2018-03-22
EP3564378A1 (en) 2019-11-06
CA2837393A1 (en) 2012-12-06
PL2714911T3 (pl) 2017-05-31
SMT201700110B (it) 2017-03-08
US20170247421A1 (en) 2017-08-31
HRP20180339T1 (hr) 2018-03-23
PT2714910T (pt) 2018-03-09
CN103717742A (zh) 2014-04-09
EA201391548A1 (ru) 2014-06-30
US20140178424A1 (en) 2014-06-26
US20160159867A1 (en) 2016-06-09
CN107098977A (zh) 2017-08-29
PT3564378T (pt) 2024-01-26
SI2714911T1 (sl) 2017-03-31
LT2714910T (lt) 2018-03-12
HUE030823T2 (en) 2017-06-28
WO2012163810A1 (en) 2012-12-06
IL229529B1 (en) 2023-01-01
EP4296361A2 (en) 2023-12-27
BR112013030395A2 (pt) 2016-12-13
JP2017012160A (ja) 2017-01-19
EP3564378B1 (en) 2023-11-01
MX2013013924A (es) 2013-12-16
SG195037A1 (en) 2013-12-30
PT2714911T (pt) 2017-02-06
HRP20231749T1 (hr) 2024-03-15
HUE044772T2 (hu) 2019-11-28
HRP20170094T1 (hr) 2017-03-24
JP2014516532A (ja) 2014-07-17
EP4296361A3 (en) 2024-02-28
SI3138916T1 (sl) 2019-08-30
CY1121936T1 (el) 2020-10-14
US10093722B2 (en) 2018-10-09
LT3138916T (lt) 2019-08-26
WO2012163811A1 (en) 2012-12-06
DK3564378T3 (da) 2024-01-08
CY1118599T1 (el) 2017-07-12
US10377816B2 (en) 2019-08-13
FI3564378T3 (fi) 2024-01-18
EP3138916B1 (en) 2019-06-19
HUE037126T2 (hu) 2018-08-28
DK3564378T5 (da) 2024-09-02
MX346200B (es) 2017-03-10
ME02600B (me) 2017-06-20
PL3138916T3 (pl) 2019-11-29
US9409974B2 (en) 2016-08-09
CN103717742B (zh) 2018-05-22
BR112013030395B1 (pt) 2022-11-01
WO2012163817A3 (en) 2013-03-21
CN103732750A (zh) 2014-04-16
IL229529A0 (en) 2014-01-30
ES2615737T3 (es) 2017-06-08
EP2714910B1 (en) 2018-01-10
US9644024B2 (en) 2017-05-09
PL3564378T3 (pl) 2024-03-11
DK3138916T3 (da) 2019-08-26
HRP20191291T1 (hr) 2019-10-18
HUE064492T2 (hu) 2024-03-28
LT2714911T (lt) 2017-02-10
EA030898B1 (ru) 2018-10-31
EP3327126A1 (en) 2018-05-30
SI3564378T1 (sl) 2024-02-29
US20170362309A1 (en) 2017-12-21

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B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 6A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]