BR112014014078A8 - Composições compreendendo constructos genéticos il-12 aperfeiçoados e vacinas, imunoterapêuticos e métodos de usar os mesmos - Google Patents

Composições compreendendo constructos genéticos il-12 aperfeiçoados e vacinas, imunoterapêuticos e métodos de usar os mesmos

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Publication number
BR112014014078A8
BR112014014078A8 BR112014014078A BR112014014078A BR112014014078A8 BR 112014014078 A8 BR112014014078 A8 BR 112014014078A8 BR 112014014078 A BR112014014078 A BR 112014014078A BR 112014014078 A BR112014014078 A BR 112014014078A BR 112014014078 A8 BR112014014078 A8 BR 112014014078A8
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methods
compositions
nucleic acid
immunotherapeutics
vaccines
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BR112014014078A
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English (en)
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BR112014014078A2 (pt
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B Weiner David
Jian Yan
P Morrow Matthew
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The Trustees Of The Univ Of Pennsylvania
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Publication of BR112014014078A8 publication Critical patent/BR112014014078A8/pt

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    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
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    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A61K38/208—IL-12
    • A—HUMAN NECESSITIES
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A61K38/2086—IL-13 to IL-16
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    • A61K39/00114—Interleukins [IL]
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    • A61K39/12—Viral antigens
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    • A61P33/00—Antiparasitic agents
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5434—IL-12
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
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    • A61K2039/53—DNA (RNA) vaccination
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    • A61K2039/55522—Cytokines; Lymphokines; Interferons
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    • C07K2319/00—Fusion polypeptide
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    • C12N2710/00011—Details
    • C12N2710/10011—Adenoviridae
    • C12N2710/10041—Use of virus, viral particle or viral elements as a vector
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    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C12N2710/16034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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    • C12N2730/00—Reverse transcribing DNA viruses
    • C12N2730/00011—Details
    • C12N2730/10011—Hepadnaviridae
    • C12N2730/10111—Orthohepadnavirus, e.g. hepatitis B virus
    • C12N2730/10171—Demonstrated in vivo effect

Abstract

composições compreendendo constructos genéticos il -12 aperfeiçoados e vacinas, imunoterapêuticos e métodos de uso dos mesmos. moléculas de ácido nucleico e composições compreendendo: uma sequência de ácido nucleico que codifica subunidade p35 de il-12 ou um fragmento funcional da mesma e/ou uma sequência de ácido nucleico que codifica subunidade p40 de il-12 ou um fragmento funcional da mesma são divulgadas. moléculas de ácido nucleico e composições compreendendo ainda uma sequência de ácido nucleico que codifica um imunógeno são também divulgadas. método para modular resposta imune e métodos para induzir uma resposta imune contra um imunógeno são divulgados. métodos de vacinação terapêutica e profilática também são divulgados.
BR112014014078A 2011-12-12 2012-12-11 Composições compreendendo constructos genéticos il-12 aperfeiçoados e vacinas, imunoterapêuticos e métodos de usar os mesmos BR112014014078A8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161569600P 2011-12-12 2011-12-12
US61/569,600 2011-12-12
PCT/US2012/069017 WO2013090296A1 (en) 2011-12-12 2012-12-11 Compositions, comprising improved il-12 genetic constructs and vaccines, immunotherapeutics and methods of using the same

Publications (2)

Publication Number Publication Date
BR112014014078A2 BR112014014078A2 (pt) 2018-10-09
BR112014014078A8 true BR112014014078A8 (pt) 2021-09-28

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BR112014014078A BR112014014078A8 (pt) 2011-12-12 2012-12-11 Composições compreendendo constructos genéticos il-12 aperfeiçoados e vacinas, imunoterapêuticos e métodos de usar os mesmos

Country Status (13)

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US (4) US9272024B2 (pt)
EP (2) EP3336096A1 (pt)
JP (4) JP6333730B2 (pt)
KR (4) KR20220132652A (pt)
CN (1) CN104245719B (pt)
AU (1) AU2012352457B2 (pt)
BR (1) BR112014014078A8 (pt)
CA (1) CA2858893A1 (pt)
EA (1) EA026926B1 (pt)
HK (1) HK1205130A1 (pt)
MX (2) MX354986B (pt)
WO (1) WO2013090296A1 (pt)
ZA (1) ZA201404199B (pt)

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