DK0681483T3 - Præparater og fremgangsmåder til administration af genetisk materiale - Google Patents
Præparater og fremgangsmåder til administration af genetisk materialeInfo
- Publication number
- DK0681483T3 DK0681483T3 DK94909492T DK94909492T DK0681483T3 DK 0681483 T3 DK0681483 T3 DK 0681483T3 DK 94909492 T DK94909492 T DK 94909492T DK 94909492 T DK94909492 T DK 94909492T DK 0681483 T3 DK0681483 T3 DK 0681483T3
- Authority
- DK
- Denmark
- Prior art keywords
- methods
- individual
- protein
- disclosed
- cells
- Prior art date
Links
- 108090000623 proteins and genes Proteins 0.000 title abstract 6
- 238000000034 method Methods 0.000 title abstract 5
- 102000004169 proteins and genes Human genes 0.000 title abstract 5
- 238000002360 preparation method Methods 0.000 title 1
- 239000000427 antigen Substances 0.000 abstract 2
- 102000036639 antigens Human genes 0.000 abstract 2
- 108091007433 antigens Proteins 0.000 abstract 2
- 102000039446 nucleic acids Human genes 0.000 abstract 2
- 108020004707 nucleic acids Proteins 0.000 abstract 2
- 150000007523 nucleic acids Chemical class 0.000 abstract 2
- 208000023275 Autoimmune disease Diseases 0.000 abstract 1
- 239000003623 enhancer Substances 0.000 abstract 1
- 230000003463 hyperproliferative effect Effects 0.000 abstract 1
- 230000003053 immunization Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000002773 nucleotide Substances 0.000 abstract 1
- 125000003729 nucleotide group Chemical group 0.000 abstract 1
- 239000002245 particle Substances 0.000 abstract 1
- 244000052769 pathogen Species 0.000 abstract 1
- 230000001717 pathogenic effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 102000040430 polynucleotide Human genes 0.000 abstract 1
- 108091033319 polynucleotide Proteins 0.000 abstract 1
- 239000002157 polynucleotide Substances 0.000 abstract 1
- 230000001177 retroviral effect Effects 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/193—Colony stimulating factors [CSF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/0225—Spirochetes, e.g. Treponema, Leptospira, Borrelia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/205—Rhabdoviridae, e.g. rabies virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/21—Retroviridae, e.g. equine infectious anemia virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/29—Hepatitis virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/29—Hepatitis virus
- A61K39/292—Serum hepatitis virus, hepatitis B virus, e.g. Australia antigen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/0008—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/53—DNA (RNA) vaccination
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2730/00—Reverse transcribing DNA viruses
- C12N2730/00011—Details
- C12N2730/10011—Hepadnaviridae
- C12N2730/10111—Orthohepadnavirus, e.g. hepatitis B virus
- C12N2730/10122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2730/00—Reverse transcribing DNA viruses
- C12N2730/00011—Details
- C12N2730/10011—Hepadnaviridae
- C12N2730/10111—Orthohepadnavirus, e.g. hepatitis B virus
- C12N2730/10134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/13011—Gammaretrovirus, e.g. murine leukeamia virus
- C12N2740/13022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
- C12N2740/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
- C12N2740/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16211—Human Immunodeficiency Virus, HIV concerning HIV gagpol
- C12N2740/16222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16211—Human Immunodeficiency Virus, HIV concerning HIV gagpol
- C12N2740/16234—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16311—Human Immunodeficiency Virus, HIV concerning HIV regulatory proteins
- C12N2740/16322—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16311—Human Immunodeficiency Virus, HIV concerning HIV regulatory proteins
- C12N2740/16334—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/20011—Rhabdoviridae
- C12N2760/20111—Lyssavirus, e.g. rabies virus
- C12N2760/20122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/20011—Rhabdoviridae
- C12N2760/20111—Lyssavirus, e.g. rabies virus
- C12N2760/20134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/24011—Flaviviridae
- C12N2770/24211—Hepacivirus, e.g. hepatitis C virus, hepatitis G virus
- C12N2770/24222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/24011—Flaviviridae
- C12N2770/24211—Hepacivirus, e.g. hepatitis C virus, hepatitis G virus
- C12N2770/24234—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A90/00—Technologies having an indirect contribution to adaptation to climate change
- Y02A90/10—Information and communication technologies [ICT] supporting adaptation to climate change, e.g. for weather forecasting or climate simulation
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Virology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Mycology (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Communicable Diseases (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US834293A | 1993-01-26 | 1993-01-26 | |
US2933693A | 1993-03-11 | 1993-03-11 | |
US9323593A | 1993-07-15 | 1993-07-15 | |
US12496293A | 1993-09-21 | 1993-09-21 | |
US08/125,012 US5593972A (en) | 1993-01-26 | 1993-09-21 | Genetic immunization |
US08/979,385 US5981505A (en) | 1993-01-26 | 1994-01-26 | Compositions and methods for delivery of genetic material |
US49568495A | 1995-08-28 | 1995-08-28 | |
US09/359,975 US7001759B1 (en) | 1993-01-26 | 1999-07-23 | Compositions and methods for delivery of genetic material |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0681483T3 true DK0681483T3 (da) | 2005-11-21 |
Family
ID=38247352
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK94909492T DK0681483T3 (da) | 1993-01-26 | 1994-01-26 | Præparater og fremgangsmåder til administration af genetisk materiale |
Country Status (14)
Country | Link |
---|---|
US (1) | US8304234B2 (da) |
EP (1) | EP0681483B1 (da) |
JP (1) | JP3701966B2 (da) |
AT (1) | ATE302854T1 (da) |
AU (1) | AU675702B2 (da) |
CA (1) | CA2153593C (da) |
DE (1) | DE69434469T2 (da) |
DK (1) | DK0681483T3 (da) |
ES (1) | ES2249760T3 (da) |
HU (1) | HU219767B (da) |
IL (1) | IL108449A (da) |
NZ (1) | NZ262582A (da) |
PT (1) | PT681483E (da) |
WO (1) | WO1994016737A1 (da) |
Families Citing this family (136)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0714308A4 (en) * | 1993-08-26 | 1998-07-29 | Univ California | METHOD, COMPOSITIONS AND DEVICES FOR THE DELIVERY OF NAKED POLYNUCLEOTIDES THAT ENCODE BIOLOGICALLY ACTIVE PEPTIDES |
US6348449B1 (en) | 1993-09-21 | 2002-02-19 | The Trustees Of The University Of Pennsylvania | Methods of inducing mucosal immunity |
US6235888B1 (en) | 1994-10-05 | 2001-05-22 | The General Hospital Corporation | Hepatitis C virus vaccine |
RU2189254C2 (ru) * | 1995-06-06 | 2002-09-20 | Америкэн Хоум Продактс Корпорэйшн | Вакцины против вирусов гепатита |
USRE38490E1 (en) | 1995-11-16 | 2004-04-06 | Baylor College Of Medicine | Method for identifying metastatic sequences |
WO1997025860A1 (en) * | 1996-01-19 | 1997-07-24 | Allegheny University Of The Health Sciences | Cellular immunogens useful as cancer vaccines |
USRE38392E1 (en) | 1996-01-30 | 2004-01-20 | Baylor College Of Medicine | Method for identifying metastatic sequences |
US6168918B1 (en) | 1996-01-31 | 2001-01-02 | American Home Products Corp. | Method of detecting foreign DNA integrated in eukaryotic chromosomes |
DE69734585T2 (de) * | 1996-02-22 | 2006-08-10 | Merck & Co., Inc. | Synthetische hiv-gene |
US6534312B1 (en) | 1996-02-22 | 2003-03-18 | Merck & Co., Inc. | Vaccines comprising synthetic genes |
US5851804A (en) * | 1996-05-06 | 1998-12-22 | Apollon, Inc. | Chimeric kanamycin resistance gene |
EP1579814A3 (en) | 1996-05-17 | 2006-06-14 | Roche Diagnostics Operations, Inc. | Methods and apparatus for sampling and analyzing body fluid |
US20020010406A1 (en) | 1996-05-17 | 2002-01-24 | Douglas Joel S. | Methods and apparatus for expressing body fluid from an incision |
US7828749B2 (en) | 1996-05-17 | 2010-11-09 | Roche Diagnostics Operations, Inc. | Blood and interstitial fluid sampling device |
US7666150B2 (en) | 1996-05-17 | 2010-02-23 | Roche Diagnostics Operations, Inc. | Blood and interstitial fluid sampling device |
US7235056B2 (en) | 1996-05-17 | 2007-06-26 | Amira Medical | Body fluid sampling device and methods of use |
US5846946A (en) * | 1996-06-14 | 1998-12-08 | Pasteur Merieux Serums Et Vaccins | Compositions and methods for administering Borrelia DNA |
AU728422B2 (en) * | 1996-06-21 | 2001-01-11 | Merck & Co., Inc. | Vaccines comprising synthetic genes |
BR9712366A (pt) * | 1996-10-23 | 1999-08-31 | American Home Prod | Gene de gd2 do vírus do herpes simples hsv2 isolado, plasmídeo compreendendo o mesmo, e, processos de induzir, em indivíduo, uma resposta imune contra hsv2 gd2, de tratar um indíviduo que está infectado com hsv, e, de prevenir que um indivíduo fique infectado com hsv |
CN1183968C (zh) | 1996-10-23 | 2005-01-12 | 宾夕法尼亚州立大学托管会 | 改良疫苗 |
AU732445B2 (en) * | 1996-11-01 | 2001-04-26 | Genespan Corporation | Stabilized transient gene expression |
US6146847A (en) * | 1996-11-01 | 2000-11-14 | Genespan Corporation | Stabilized transient gene expression |
WO1998024912A2 (en) * | 1996-12-04 | 1998-06-11 | Heska Corporation | Recombinant plague vaccine |
GB9626539D0 (en) * | 1996-12-20 | 1997-02-05 | Univ Liverpool | A method of enhancing the rate of transfection of cells |
AU743616B2 (en) * | 1997-02-07 | 2002-01-31 | Merck & Co., Inc. | Synthetic HIV gag genes |
US6696291B2 (en) | 1997-02-07 | 2004-02-24 | Merck & Co., Inc. | Synthetic HIV gag genes |
US6217900B1 (en) * | 1997-04-30 | 2001-04-17 | American Home Products Corporation | Vesicular complexes and methods of making and using the same |
AU8298298A (en) * | 1997-07-08 | 1999-02-08 | Chiron Corporation | Use of submicron oil-in-water emulsions with dna vaccines |
EP0893507A1 (en) * | 1997-07-25 | 1999-01-27 | Institut Gustave Roussy | Use of MHC class II ligands (CD4 and LAG-3) as adjuvant for vaccination and of LAG-3 in cancer treatment |
US6818627B1 (en) | 1997-08-14 | 2004-11-16 | The Trustees Of The University Of Pennsylvania | Functional fragments of HIV-1 Vpr protein and methods of using the same |
EP2044950B1 (en) | 1997-09-18 | 2012-06-27 | The Trustees of The University of Pennsylvania | Attenuated VIF DNA immunization cassettes for genetic vaccines |
GB9720585D0 (en) * | 1997-09-26 | 1997-11-26 | Smithkline Beecham Biolog | Vaccine |
WO1999021591A1 (en) | 1997-10-28 | 1999-05-06 | American Home Products Corporation | Compositions and methods for delivery of genetic material |
US6252058B1 (en) | 1997-11-05 | 2001-06-26 | Timothy C. Thompson | Sequences for targeting metastatic cells |
KR100628411B1 (ko) * | 1998-01-30 | 2006-09-28 | 더 제너럴 하스피탈 코포레이션 | C형 간염 바이러스의 비구조 단백질을 이용한 유전자면역법 |
CA2323074A1 (en) | 1998-03-13 | 1999-09-16 | Baylor College Of Medicine | Compositions and methods for the treatment and prevention of metastatic disorders |
AU5366099A (en) | 1998-08-20 | 2000-03-14 | Connaught Laboratories Limited | Nucleic acid molecules encoding inclusion membrane protein of (chlamydia) |
US6693087B1 (en) | 1998-08-20 | 2004-02-17 | Aventis Pasteur Limited | Nucleic acid molecules encoding POMP91A protein of Chlamydia |
US6686339B1 (en) | 1998-08-20 | 2004-02-03 | Aventis Pasteur Limited | Nucleic acid molecules encoding inclusion membrane protein C of Chlamydia |
FR2785293B1 (fr) | 1998-10-30 | 2002-07-05 | Pasteur Merieux Serums Vacc | Acides nucleiques et polypeptides specifiques des souches pathogenes du genre neisseria |
JP2003523721A (ja) | 1998-12-31 | 2003-08-12 | カイロン コーポレイション | 抗原性hivc型ポリペプチドをコードするポリヌクレオチド、ポリペプチド、およびそれらの使用 |
BR0009884A (pt) | 1999-04-21 | 2002-01-08 | American Home Prod | Processos e composições para a inibição da função das sequências de polinucleotìdeos |
BR0010155A (pt) | 1999-04-30 | 2002-01-15 | Univ Pennsylvania | Proteìnas isolada, e quimérica, composição, molécula de ácido nucleico, plasmìdeo, vacina recombinante ou vacina atenuada, composição de vacina recombinante ou composição de vacina atenuada, composição farmacêutica, métodos de imunizar um indivìduo contra um imunógeno, proteìna não-cd80 isolada, molécula de ácido nucleico, e, método de imunossuprimir um indivìduo |
WO2001030382A1 (en) | 1999-10-22 | 2001-05-03 | Aventis Pasteur Limited | Method of inducing and/or enhancing an immune response to tumor antigens |
KR100863823B1 (ko) | 1999-12-22 | 2008-10-15 | 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 | 코스미드 dna 작제물 및 이를 제조하고 이용하는 방법 |
US6998263B2 (en) | 2000-02-09 | 2006-02-14 | Genvec, Inc. | Methods of preparing and using a viral vector library |
US20040137436A1 (en) | 2000-04-18 | 2004-07-15 | Brendan Larder | Method for measuring drug resistance |
EP1792995A3 (en) | 2000-05-08 | 2007-06-13 | Sanofi Pasteur Limited | Chlamydia secretory locus orf and uses thereof |
DK1282702T3 (da) | 2000-05-10 | 2007-04-02 | Sanofi Pasteur Ltd | Immunogene polypeptider, som er kodet af KAGE-minigener, og anvendelser deraf |
WO2002014362A2 (en) | 2000-08-17 | 2002-02-21 | Tripep Ab | A hepatitis c virus non-structural ns3/4a fusion gene |
US7022830B2 (en) | 2000-08-17 | 2006-04-04 | Tripep Ab | Hepatitis C virus codon optimized non-structural NS3/4A fusion gene |
US6858590B2 (en) | 2000-08-17 | 2005-02-22 | Tripep Ab | Vaccines containing ribavirin and methods of use thereof |
US6680059B2 (en) | 2000-08-29 | 2004-01-20 | Tripep Ab | Vaccines containing ribavirin and methods of use thereof |
AU2001285633A1 (en) | 2000-08-25 | 2002-03-04 | Aventis Pasteur Limited | Haemophilus influenzae lipopolysaccharide inner-core oligosaccharide epitopes as vaccines for the prevention of haemophilus influenzae infections |
AU2002247008B2 (en) | 2001-01-22 | 2006-02-09 | F. Hoffmann-La Roche Ag | Lancet device having capillary action |
AU2002329176A1 (en) | 2001-05-25 | 2002-12-23 | The Trustees Of The University Of Pennsylvania | Targeted particles and methods of using the same |
CA2634992C (en) | 2001-07-05 | 2012-10-16 | Novartis Vaccines And Diagnostics, Inc. | Polynucleotides encoding antigenic hiv type c polypeptides, polypeptides and uses thereof |
EP1285971B1 (en) * | 2001-08-08 | 2007-10-10 | Tibotec Pharmaceuticals Ltd. | Methods for the phenotypic and genotypic assessment of the drug sensitivity of HIV integrase variants |
US6958211B2 (en) | 2001-08-08 | 2005-10-25 | Tibotech Bvba | Methods of assessing HIV integrase inhibitor therapy |
DE10142232B4 (de) | 2001-08-29 | 2021-04-29 | Roche Diabetes Care Gmbh | Verfahren zur Herstellung eines analytischen Hilfsmittels mit Lanzette und Testelement |
US7462491B2 (en) | 2002-01-31 | 2008-12-09 | Baylor College Of Medicine | Methods and compositions for diagnosis and monitoring of prostate cancer progression by detection of serum caveolin |
CN100593544C (zh) | 2002-03-15 | 2010-03-10 | 惠氏控股有限公司 | 酶活性减少的非典型流感嗜血杆菌的p4蛋白突变体 |
US20040180438A1 (en) | 2002-04-26 | 2004-09-16 | Pachuk Catherine J. | Methods and compositions for silencing genes without inducing toxicity |
EP1356820A1 (en) | 2002-04-26 | 2003-10-29 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | DNA vaccine combined with an inducer of tumor cell apoptosis |
AU2003243663A1 (en) | 2002-06-20 | 2004-01-06 | The Trustees Of The University Of Pennsylvania | Vaccines for suppressing ige-mediated allergic disease and methods for using the same |
ES2381224T3 (es) | 2002-10-29 | 2012-05-24 | Coley Pharmaceutical Group, Inc. | Uso de oligonucleótidos CPG en el tratamiento de infección por el virus de la hepatitis C |
US7455841B2 (en) | 2002-11-19 | 2008-11-25 | The Trustees Of The University Of Pennsylvania | Genetic constructs and compositions comprising RRE and CTE and uses thereof |
NZ570709A (en) | 2003-06-13 | 2010-04-30 | Univ Pennsylvania | Nucleic acid sequences encoding and compositions comprising IgE signal peptide and/or IL-15 and methods for using the same |
WO2004112706A2 (en) | 2003-06-13 | 2004-12-29 | The Trustees Of The University Of Pennsylvania | Vaccines, immunotherapeutics and methods for using the same |
US7999071B2 (en) | 2003-12-12 | 2011-08-16 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Human cytotoxic T-lymphoctye epitope and its agonist eptiope from the non-variable number of tandem repeat sequence of MUC-1 |
TW200613554A (en) | 2004-06-17 | 2006-05-01 | Wyeth Corp | Plasmid having three complete transcriptional units and immunogenic compositions for inducing an immune response to HIV |
EP1802335A2 (en) | 2004-10-21 | 2007-07-04 | Wyeth a Corporation of the State of Delaware | Immunogenic compositions of staphylococcus epidermidis polypeptide and polynucleotide antigens |
WO2007050095A2 (en) | 2004-11-19 | 2007-05-03 | The Trustees Of The University Of Pennsylvania | Improved vaccines and methods for using the same |
ES2374458T3 (es) | 2006-01-13 | 2012-02-16 | The Trustees Of The University Of Pennsylvania | Vacunas y agentes inmunoterapéuticos que utilizan il-15 optimizada en codones, y métodos para utilización de los mismos. |
WO2007082105A2 (en) | 2006-01-16 | 2007-07-19 | Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Chlamydia vaccine |
WO2007109583A2 (en) | 2006-03-17 | 2007-09-27 | The Government Of The United States Of America As Represented By The Secretary, Department Of Health And Human Services | Compositions and methods for prevention or treatment of neoplastic disease in a mammalian subject |
EP2594576B1 (en) | 2006-07-28 | 2015-07-01 | The Trustees of The University of Pennsylvania | Improved HIV vaccines |
WO2009022236A2 (en) | 2007-08-16 | 2009-02-19 | Tripep Ab | Immunogen platform |
MX2010005229A (es) | 2007-11-12 | 2010-11-05 | Univ Pennsylvania | Vacunas novedosas contra sub-tipos multiples de virus de influenza. |
WO2009065032A1 (en) | 2007-11-14 | 2009-05-22 | Vgx Pharmaceuticals, Inc. | Antibody production elicited by a dna vaccine delivered by electroporation |
WO2010044919A2 (en) | 2008-05-28 | 2010-04-22 | Vgx Pharmaceuticals, Inc. | Smallpox dna vaccine and the antigens therein that elicit an immune response |
KR101609233B1 (ko) | 2008-10-29 | 2016-04-05 | 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 | 개량된 hcv 백신 및 이를 이용하는 방법 |
US8921536B2 (en) | 2008-10-29 | 2014-12-30 | The Trustees Of The University Of Pennsylvania | HCV vaccines and methods for using the same |
CA3001374A1 (en) | 2008-11-17 | 2010-05-20 | Vgx Pharmaceuticals, Llc | Antigens that elicit immune response against flavivirus and methods of using same |
US9050287B2 (en) | 2009-01-23 | 2015-06-09 | The Trustees Of The University Of Pennsylvania | Vaccines for human papilloma virus and methods for using the same |
CA2653478A1 (en) | 2009-01-23 | 2010-07-23 | Gregg Martin | Automated wash system for industrial vehicles |
CN102439150A (zh) | 2009-03-27 | 2012-05-02 | 法国国家健康医学研究院 | 用于癌症治疗的卡那霉素反义核酸 |
CA2777705C (en) | 2009-11-02 | 2019-03-12 | The Trustees Of The University Of Pennsylvania | Foot and mouth disease virus (fmdv) consensus proteins, coding sequences therefor and vaccines made therefrom |
US8298820B2 (en) | 2010-01-26 | 2012-10-30 | The Trustees Of The University Of Pennsylvania | Influenza nucleic acid molecules and vaccines made therefrom |
CN102781952B (zh) | 2010-02-08 | 2015-09-02 | 宾夕法尼亚大学托管会 | 编码rantes的核酸分子、包含其的组合物以及其使用方法 |
CN110195069A (zh) | 2010-09-27 | 2019-09-03 | 宾夕法尼亚大学托管会 | 共有抗原构建体和由其制备的疫苗以及使用所述疫苗治疗疟疾的方法 |
EA027315B1 (ru) | 2010-11-12 | 2017-07-31 | Дзе Трастиз Оф Дзе Юниверсити Оф Пенсильвания | Молекула нуклеиновой кислоты и белок для индукции иммунного ответа против антигена рака предстательной железы, плазмида, вектор экспрессии, способ лечения и фармацевтическая композиция |
AU2012212264B2 (en) | 2011-01-31 | 2016-01-28 | The Trustees Of The University Of Pennsylvania | Nucleic acid molecules encoding novel herpes antigens, vaccine comprising the same, and methods of use thereof |
US9238679B2 (en) | 2011-02-11 | 2016-01-19 | The Trustees Of The University Of Pennslyvania | Nucleic acid molecule encoding hepatitis B virus core protein and surface antigen protein and vaccine comprising the same |
KR101942372B1 (ko) | 2011-02-11 | 2019-04-12 | 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 | B형 간염 바이러스 코어 단백질을 암호화하는 핵산 분자 및 이를 포함하는 백신 |
KR20150029756A (ko) | 2011-06-10 | 2015-03-18 | 블루버드 바이오, 인코포레이티드. | 부신백질이영양증 및 부신척수신경병증을 위한 유전자 요법 벡터 |
KR102314421B1 (ko) | 2011-07-11 | 2021-10-19 | 이노비오 파마수티컬즈, 인크. | 교차-보호성 아레나바이러스 백신 및 이의 사용 방법 |
KR102101819B1 (ko) | 2011-12-12 | 2020-04-21 | 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 | 개선된 il-12 유전적 컨스트럭트 및 백신을 포함하는 조성물, 면역치료제 및 이를 이용하는 방법 |
JP6407028B2 (ja) | 2011-12-12 | 2018-10-17 | ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア | MRSAのPBP2a及びその断片を含むタンパク質、それをコードする核酸、並びにMRSA感染を予防する及び治療するための組成物及びそれらの使用 |
MX363667B (es) | 2012-04-10 | 2019-03-29 | Univ Pennsylvania | Antigenos de consenso del virus sincitial respiratorio humano, constructos de acido nucleico y vacunas hechas de estos, y metodos para utilizarlas. |
KR20220012403A (ko) | 2012-04-12 | 2022-02-03 | 더 트러스티스 오브 더 유니버시티 오브 펜실베니아 | 필로바이러스 공통 항원, 이로부터 제조된 핵산 구조체 및 백신, 및 이를 사용하는 방법 |
EP3597741A1 (en) | 2012-04-27 | 2020-01-22 | Duke University | Genetic correction of mutated genes |
US9738879B2 (en) | 2012-04-27 | 2017-08-22 | Duke University | Genetic correction of mutated genes |
CN104812401B (zh) | 2012-12-13 | 2017-10-13 | 宾夕法尼亚大学理事会 | Wt1疫苗 |
KR20150130438A (ko) | 2013-03-12 | 2015-11-23 | 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 | 인간 파밀로마 바이러스용 개선된 백신 및 이것을 사용하는 방법 |
US11419925B2 (en) | 2013-03-15 | 2022-08-23 | The Trustees Of The University Of Pennsylvania | Cancer vaccines and methods of treatment using the same |
JP6817062B2 (ja) | 2013-03-15 | 2021-01-20 | ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア | 蹄疫ウイルス(fmdv)コンセンサスタンパク質、そのコード配列、およびそれから作成されるワクチン |
US9828582B2 (en) | 2013-03-19 | 2017-11-28 | Duke University | Compositions and methods for the induction and tuning of gene expression |
KR20230136697A (ko) | 2013-06-05 | 2023-09-26 | 듀크 유니버시티 | Rna-가이드 유전자 편집 및 유전자 조절 |
EP3013364B1 (en) | 2013-06-25 | 2022-08-03 | International AIDS Vaccine Initiative, Inc. | Tuberculosis compositions and methods of using the same |
EP3080159A4 (en) | 2013-12-13 | 2017-08-02 | The Trustees Of The University Of Pennsylvania | Dna antibody constructs and method of using same |
US10759836B2 (en) | 2014-07-18 | 2020-09-01 | University Of Washington | Cancer vaccine compositions and methods of use thereof |
WO2016081924A1 (en) | 2014-11-20 | 2016-05-26 | Duke University | Compositions, systems and methods for cell therapy |
AU2015355126B9 (en) | 2014-12-01 | 2020-03-26 | Inovio Pharmaceuticals, Inc. | DNA antibody constructs and method of using same |
JP6929791B2 (ja) | 2015-02-09 | 2021-09-01 | デューク ユニバーシティ | エピゲノム編集のための組成物および方法 |
WO2016179034A2 (en) | 2015-05-01 | 2016-11-10 | The Trustees Of The University Of Pennsylvania | Methods and compositions for stimulating immune response using potent immunostimulatory rna motifs |
EP3325018A4 (en) | 2015-07-22 | 2019-04-24 | Duke University | HIGH EFFICIENCY SCREENING OF REGULATORY ELEMENT FUNCTION USING EPIGENOUS EDITING TECHNOLOGIES |
ES2929110T3 (es) | 2015-08-25 | 2022-11-24 | Univ Duke | Composiciones y métodos para mejorar la especificidad en ingeniería genética usando endonucleasas guiadas por ARN |
US11970710B2 (en) | 2015-10-13 | 2024-04-30 | Duke University | Genome engineering with Type I CRISPR systems in eukaryotic cells |
US11180538B2 (en) | 2015-11-13 | 2021-11-23 | University Of Utah Research Foundation | Combinatorial gene construct and non-viral delivery for anti-obesity |
EP3384055A4 (en) | 2015-11-30 | 2019-04-17 | Duke University | THERAPEUTIC TARGETS FOR CORRECTING HUMAN DYSTROPHINE BY GENE EDITING AND METHOD OF USE |
WO2017136758A1 (en) | 2016-02-05 | 2017-08-10 | Inovio Pharmaceuticals, Inc. | Cancer vaccines and methods of treatment using the same |
US20190134221A1 (en) | 2016-05-05 | 2019-05-09 | Duke University | Crispr/cas-related methods and compositions for treating duchenne muscular dystrophy |
AU2017285424B2 (en) | 2016-06-16 | 2022-08-18 | International Aids Vaccine Initiative, Inc. | Tuberculosis compositions and methods of treating or preventing tuberculosis |
CN109843321A (zh) | 2016-06-22 | 2019-06-04 | 国际艾滋病疫苗行动组织公司 | 作为结核病疫苗的重组巨细胞病毒载体 |
JP7490211B2 (ja) | 2016-07-19 | 2024-05-27 | デューク ユニバーシティ | Cpf1に基づくゲノム編集の治療適用 |
EP3532616A1 (en) | 2016-10-28 | 2019-09-04 | Editas Medicine, Inc. | Crispr/cas-related methods and compositions for treating herpes simplex virus |
US11638749B2 (en) | 2017-10-17 | 2023-05-02 | International Aids Vaccine Initiative, Inc. | Tuberculosis antigen cassettes |
KR102637862B1 (ko) | 2017-12-13 | 2024-02-19 | 이노비오 파마수티컬즈, 인크. | 메소텔린을 표적으로 하는 암 백신 및 이의 용도 |
MX2020006216A (es) | 2017-12-13 | 2020-08-31 | Inovio Pharmaceuticals Inc | Vacunas contra el cancer dirigidas a prame y sus usos. |
CA3084135C (en) | 2017-12-13 | 2024-03-05 | Inovio Pharmaceuticals, Inc. | Cancer vaccines targeting muc16 and uses thereof |
IT201900007060A1 (it) | 2019-05-21 | 2020-11-21 | St Superiore Di Sanita | Cellule tumorali ingegnerizzate e loro usi |
IT201900012540A1 (it) | 2019-07-22 | 2021-01-22 | Humanitas Mirasole Spa | Inibitori di CHI3L1 e loro usi |
CA3159320A1 (en) | 2019-12-06 | 2021-06-10 | Scribe Therapeutics Inc. | Particle delivery systems |
EP4351660A2 (en) | 2021-06-09 | 2024-04-17 | Scribe Therapeutics Inc. | Particle delivery systems |
WO2023227669A2 (en) | 2022-05-26 | 2023-11-30 | UCB Biopharma SRL | Novel nucleic acid-editing proteins |
Family Cites Families (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3688765A (en) * | 1969-10-03 | 1972-09-05 | Jack S Gasaway | Hypodermic injection device |
GB1594097A (en) * | 1976-12-16 | 1981-07-30 | Int Inst Of Differentiation | Production of specific immune nucleic acids cell dialysates and antibodies |
US4394448A (en) * | 1978-02-24 | 1983-07-19 | Szoka Jr Francis C | Method of inserting DNA into living cells |
US4945050A (en) * | 1984-11-13 | 1990-07-31 | Cornell Research Foundation, Inc. | Method for transporting substances into living cells and tissues and apparatus therefor |
US5036006A (en) * | 1984-11-13 | 1991-07-30 | Cornell Research Foundation, Inc. | Method for transporting substances into living cells and tissues and apparatus therefor |
US4596556A (en) * | 1985-03-25 | 1986-06-24 | Bioject, Inc. | Hypodermic injection apparatus |
GB8508845D0 (en) * | 1985-04-04 | 1985-05-09 | Hoffmann La Roche | Vaccinia dna |
US4680027A (en) * | 1985-12-12 | 1987-07-14 | Injet Medical Products, Inc. | Needleless hypodermic injection device |
US4806463A (en) * | 1986-05-23 | 1989-02-21 | Worcester Foundation For Experimental Biology | Inhibition of HTLV-III by exogenous oligonucleotides |
US5024656A (en) * | 1988-08-30 | 1991-06-18 | Injet Medical Products, Inc. | Gas-pressure-regulated needleless injection system |
US5185254A (en) * | 1988-12-29 | 1993-02-09 | The Wistar Institute | Gene family of tumor-associated antigens |
JP3140757B2 (ja) | 1989-02-06 | 2001-03-05 | デイナ・フアーバー・キヤンサー・インステイテユート | パッケージング欠陥hivプロウイルス、細胞系及びその使用 |
US6214804B1 (en) * | 1989-03-21 | 2001-04-10 | Vical Incorporated | Induction of a protective immune response in a mammal by injecting a DNA sequence |
ES2116269T3 (es) * | 1989-03-21 | 1998-07-16 | Vical Inc | Expresion de secuencias exogenas de polinucleotidos en un vertebrado. |
WO1991007425A1 (en) | 1989-11-20 | 1991-05-30 | Oncogen Limited Partnership | Non-replicating recombinant-made retroviral particles used as antiviral agents and immunogens |
EP0506884B1 (en) * | 1989-12-21 | 1996-09-04 | Whitehead Institute For Biomedical Research | Method of delivering molecules into eukaryotic cells |
WO1991012329A2 (en) * | 1990-02-12 | 1991-08-22 | Board Of Regents, The University Of Texas System | Satellite cell proliferation in adult skeletal muscle |
DK0584279T3 (da) * | 1991-05-14 | 2001-06-11 | Immune Response Corp Inc | Målrettet aflevering af gener, som koder for immunogene proteiner |
CA2102918C (en) * | 1992-03-11 | 2007-05-08 | Joel R. Haynes | Genetic vaccine for immunodeficiency viruses |
AU4253493A (en) | 1992-05-21 | 1993-12-13 | Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The | Targeting gene expression to living tissue using jet injection |
US5593972A (en) * | 1993-01-26 | 1997-01-14 | The Wistar Institute | Genetic immunization |
-
1994
- 1994-01-26 ES ES94909492T patent/ES2249760T3/es not_active Expired - Lifetime
- 1994-01-26 JP JP51728594A patent/JP3701966B2/ja not_active Expired - Lifetime
- 1994-01-26 PT PT94909492T patent/PT681483E/pt unknown
- 1994-01-26 AU AU62320/94A patent/AU675702B2/en not_active Expired
- 1994-01-26 CA CA2153593A patent/CA2153593C/en not_active Expired - Lifetime
- 1994-01-26 WO PCT/US1994/000899 patent/WO1994016737A1/en active IP Right Grant
- 1994-01-26 HU HU9502229A patent/HU219767B/hu not_active IP Right Cessation
- 1994-01-26 AT AT94909492T patent/ATE302854T1/de active
- 1994-01-26 DK DK94909492T patent/DK0681483T3/da active
- 1994-01-26 EP EP94909492A patent/EP0681483B1/en not_active Expired - Lifetime
- 1994-01-26 IL IL108449A patent/IL108449A/en not_active IP Right Cessation
- 1994-01-26 NZ NZ262582A patent/NZ262582A/en not_active IP Right Cessation
- 1994-01-26 DE DE69434469T patent/DE69434469T2/de not_active Expired - Lifetime
-
2005
- 2005-12-23 US US11/317,548 patent/US8304234B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
EP0681483B1 (en) | 2005-08-24 |
HUT73099A (en) | 1996-06-28 |
CA2153593C (en) | 2010-04-13 |
ES2249760T3 (es) | 2006-04-01 |
CA2153593A1 (en) | 1994-08-04 |
HU219767B (hu) | 2001-07-30 |
NZ262582A (en) | 1997-10-24 |
JPH08509694A (ja) | 1996-10-15 |
AU675702B2 (en) | 1997-02-13 |
EP0681483A1 (en) | 1995-11-15 |
DE69434469D1 (de) | 2005-09-29 |
EP0681483A4 (en) | 1997-06-25 |
PT681483E (pt) | 2005-11-30 |
DE69434469T2 (de) | 2006-06-14 |
US20060222629A1 (en) | 2006-10-05 |
AU6232094A (en) | 1994-08-15 |
IL108449A0 (en) | 1994-04-12 |
HU9502229D0 (en) | 1995-09-28 |
ATE302854T1 (de) | 2005-09-15 |
JP3701966B2 (ja) | 2005-10-05 |
IL108449A (en) | 2011-09-27 |
WO1994016737A1 (en) | 1994-08-04 |
US8304234B2 (en) | 2012-11-06 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DK0681483T3 (da) | Præparater og fremgangsmåder til administration af genetisk materiale | |
DK0772437T3 (da) | Sammensætninger til levering af genetisk materiale | |
EP0340793A3 (en) | Endowing cells with antibody specificity | |
PT642581E (pt) | Vacinas de clostridium perfringens | |
AR003423A1 (es) | Anticuerpos monoclonales humanos de alta afinidad especificos de la proteina- f del rsv, celulas eucarioticas transfectadas; secuencia de adn y vector de expresion que lo codifican; metodo que utiliza los anticuerpos; una composicion farmaceutica que los contiene; metodo para detectar rsv y un kit de ensayo. | |
AU1986588A (en) | Growth hormone receptor | |
ATE270303T1 (de) | Gc1q-rezeptor, daran bindende hiv-1 gp120-region, verwandte peptide und antikörper | |
DE69939327D1 (de) | Funktionelle antagonisten von hedgehog-aktivität | |
ES2010727A6 (es) | Metodo para producir lineas celulares que producen anticuerpos monoclonales reactivos frente a determinantes antigenicos de gp110 o de p25 de hiv. | |
ATE293169T1 (de) | Latency associated peptide von tgf-beta um pharmazeutisch aktive proteine latent zu machen | |
DK1025236T3 (da) | Human checkpoint kinase, HCDS1, præparater og fremgangsmåde | |
Nygren et al. | 95-and 25-kDa fragments of the human immunodeficiency virus envelope glycoprotein gp120 bind to the CD4 receptor. | |
Chin et al. | Selective associations of hormonal steroids with aminoacyl transfer RNAs and control of protein synthesis | |
DK1473369T3 (da) | Præparater og fremgangsmåde til administration af genetisk materiale | |
ATE266731T1 (de) | Neue menschliche proteine, die cyclin abhängigen kinasen ähneln, sowie methoden zu deren verwendung | |
Leserman | The introversion of the immune response: a hypothesis for TB interaction | |
FR2694938B1 (fr) | Nouveaux peptides, anticorps diriges contre ces peptides, anticorps anti-idiotypiques, application a titre de medicaments, compositions pharmaceutiques et kits de diagnostic les renfermant. | |
RU2221873C2 (ru) | Способ получения каталитических антител (варианты), антигены для иммунизации и нуклеотидная последовательность |