BR112022010246A2 - Composição farmacêutica para o tratamento de câncer compreendendo proteína de fusão compreendendo proteína il-2 e proteína cd80 e inibidor de checkpoint imunológico - Google Patents
Composição farmacêutica para o tratamento de câncer compreendendo proteína de fusão compreendendo proteína il-2 e proteína cd80 e inibidor de checkpoint imunológicoInfo
- Publication number
- BR112022010246A2 BR112022010246A2 BR112022010246A BR112022010246A BR112022010246A2 BR 112022010246 A2 BR112022010246 A2 BR 112022010246A2 BR 112022010246 A BR112022010246 A BR 112022010246A BR 112022010246 A BR112022010246 A BR 112022010246A BR 112022010246 A2 BR112022010246 A2 BR 112022010246A2
- Authority
- BR
- Brazil
- Prior art keywords
- protein
- cancer
- checkpoint inhibitor
- pharmaceutical composition
- fusion protein
- Prior art date
Links
- 108020001507 fusion proteins Proteins 0.000 title abstract 6
- 101000914484 Homo sapiens T-lymphocyte activation antigen CD80 Proteins 0.000 title abstract 5
- 229940076838 Immune checkpoint inhibitor Drugs 0.000 title abstract 5
- 108010002350 Interleukin-2 Proteins 0.000 title abstract 5
- 206010028980 Neoplasm Diseases 0.000 title abstract 5
- 102100027222 T-lymphocyte activation antigen CD80 Human genes 0.000 title abstract 5
- 201000011510 cancer Diseases 0.000 title abstract 5
- 239000012274 immune-checkpoint protein inhibitor Substances 0.000 title abstract 5
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 4
- 102000037984 Inhibitory immune checkpoint proteins Human genes 0.000 title abstract 3
- 108091008026 Inhibitory immune checkpoint proteins Proteins 0.000 title abstract 3
- 102000000588 Interleukin-2 Human genes 0.000 abstract 4
- 102000037865 fusion proteins Human genes 0.000 abstract 4
- 239000012634 fragment Substances 0.000 abstract 3
- 239000004480 active ingredient Substances 0.000 abstract 2
- 210000002865 immune cell Anatomy 0.000 abstract 2
- 230000001900 immune effect Effects 0.000 abstract 2
- 239000013636 protein dimer Substances 0.000 abstract 2
- 108060003951 Immunoglobulin Proteins 0.000 abstract 1
- 239000012270 PD-1 inhibitor Substances 0.000 abstract 1
- 239000012668 PD-1-inhibitor Substances 0.000 abstract 1
- 102000018358 immunoglobulin Human genes 0.000 abstract 1
- 210000000822 natural killer cell Anatomy 0.000 abstract 1
- 229940121655 pd-1 inhibitor Drugs 0.000 abstract 1
- 229960002621 pembrolizumab Drugs 0.000 abstract 1
- 210000003289 regulatory T cell Anatomy 0.000 abstract 1
- 230000001105 regulatory effect Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/249—Interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A61K38/2013—IL-2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
- A61K38/1774—Immunoglobulin superfamily (e.g. CD2, CD4, CD8, ICAM molecules, B7 molecules, Fc-receptors, MHC-molecules)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/55—IL-2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70532—B7 molecules, e.g. CD80, CD86
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A61K2039/507—Comprising a combination of two or more separate antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Cell Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Toxicology (AREA)
- Biomedical Technology (AREA)
- Oncology (AREA)
- Endocrinology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
Abstract
COMPOSIÇÃO FARMACÊUTICA PARA O TRATAMENTO DE CÂNCER COMPREENDENDO PROTEÍNA DE FUSÃO COMPREENDENDO PROTEÍNA IL-2 E PROTEÍNA CD80 E INIBIDOR DE CHECKPOINT IMUNOLÓGICO. É fornecida uma composição farmacêutica para prevenir ou tratar câncer compreendendo, como princípios ativos, um dímero de proteína de fusão compreendendo uma proteína IL-2 ou uma variante da mesma e uma proteína CD80 ou um fragmento da mesma, e um inibidor de checkpoint imunológico. A proteína de fusão contendo um fragmento de CD80, um domínio Fc de uma imunoglobulina, e uma variante de IL-2 em uma modalidade pode ativar células imunes tais como células exterminadoras naturais bem como controlar a atividade reguladora da célula imune de células T reguladoras. Além disso, a administração combinada da proteína de fusão e um inibidor de checkpoint imunológico tal como Keytruda conhecido como um inibidor de PD-1 pode inibir eficazmente o câncer. Portanto, uma composição farmacêutica contendo, como princípios ativos, um dímero de proteína de fusão compreendendo uma proteína IL-2 ou uma variante da mesma e uma proteína CD80 ou um fragmento da mesma, e um inibidor de checkpoint imunológico pode ser eficazmente aplicado ao tratamento de câncer e tem alta aplicabilidade industrial.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR20190154632 | 2019-11-27 | ||
PCT/KR2020/017097 WO2021107689A1 (ko) | 2019-11-27 | 2020-11-27 | Il-2 단백질 및 cd80 단백질을 포함하는 융합단백질 및 면역관문 억제제를 포함하는 암 치료용 약학 조성물 |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112022010246A2 true BR112022010246A2 (pt) | 2022-09-06 |
Family
ID=76129744
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112022010246A BR112022010246A2 (pt) | 2019-11-27 | 2020-11-27 | Composição farmacêutica para o tratamento de câncer compreendendo proteína de fusão compreendendo proteína il-2 e proteína cd80 e inibidor de checkpoint imunológico |
Country Status (15)
Country | Link |
---|---|
US (2) | US11639383B2 (pt) |
EP (1) | EP4085918A4 (pt) |
JP (1) | JP2023505067A (pt) |
KR (2) | KR102400253B1 (pt) |
CN (1) | CN114786701A (pt) |
AU (1) | AU2020392166A1 (pt) |
BR (1) | BR112022010246A2 (pt) |
CA (1) | CA3161303A1 (pt) |
CL (1) | CL2022001382A1 (pt) |
IL (1) | IL293364A (pt) |
MX (1) | MX2022006426A (pt) |
PE (1) | PE20221410A1 (pt) |
TW (1) | TWI820361B (pt) |
WO (1) | WO2021107689A1 (pt) |
ZA (1) | ZA202206994B (pt) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN117660331A (zh) * | 2019-11-20 | 2024-03-08 | 吉爱希公司 | 用于培养自然杀手细胞的组合物及使用其来生产自然杀手细胞的方法 |
CA3175457A1 (en) * | 2020-03-18 | 2021-09-23 | Gi Innovation, Inc. | Pharmaceutical composition for treating cancer, comprising fusion protein comprising il-2 protein and cd80 protein and anticancer drug |
KR102461837B1 (ko) * | 2022-01-13 | 2022-11-01 | ㈜지아이이노베이션 | Cd80 세포외도메인 및 항 lag3 항체 단편을 포함하는 융합 단백질 및 이의 용도 |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5229109A (en) | 1992-04-14 | 1993-07-20 | Board Of Regents, The University Of Texas System | Low toxicity interleukin-2 analogues for use in immunotherapy |
SI2673294T1 (sl) | 2011-02-10 | 2016-08-31 | Roche Glycart Ag | Mutirani polipeptidi interlevkina-2 |
DK3180018T3 (da) | 2014-08-12 | 2019-10-28 | Massachusetts Inst Technology | Synergistisk tumorbehandling med IL-2 og integrinbindende Fc-fusionsprotein |
WO2017024465A1 (en) | 2015-08-10 | 2017-02-16 | Innovent Biologics (Suzhou) Co., Ltd. | Pd-1 antibodies |
MA45488A (fr) | 2015-10-22 | 2018-08-29 | Juno Therapeutics Gmbh | Procédés, kits et appareil de culture de cellules |
AU2016346870B2 (en) * | 2015-10-28 | 2021-04-22 | Yuhan Corporation | Dual function proteins and pharmaceutical composition comprising same |
CN109475603B (zh) | 2016-06-20 | 2023-06-13 | 科马布有限公司 | 抗pd-l1抗体 |
US20180009869A1 (en) * | 2016-07-08 | 2018-01-11 | AskGene Pharma, Inc. | Fusion Protein Comprising Leptin and Methods for Producing and Using the Same |
WO2018201014A1 (en) * | 2017-04-28 | 2018-11-01 | Five Prime Therapeutics, Inc. | Methods of treatment with cd80 extracellular domain polypeptides |
GB201709808D0 (en) * | 2017-06-20 | 2017-08-02 | Kymab Ltd | Antibodies |
JP2021502368A (ja) * | 2017-11-10 | 2021-01-28 | ウイスコンシン アラムナイ リサーチ ファウンデーシヨンWisconsin Alumni Research Foundation | 免疫療法に対する抗腫瘍免疫応答を促進するための標的化放射線療法(trt)の使用 |
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2020
- 2020-11-27 BR BR112022010246A patent/BR112022010246A2/pt unknown
- 2020-11-27 WO PCT/KR2020/017097 patent/WO2021107689A1/ko unknown
- 2020-11-27 CN CN202080082872.0A patent/CN114786701A/zh active Pending
- 2020-11-27 MX MX2022006426A patent/MX2022006426A/es unknown
- 2020-11-27 CA CA3161303A patent/CA3161303A1/en active Pending
- 2020-11-27 KR KR1020200162168A patent/KR102400253B1/ko active IP Right Grant
- 2020-11-27 TW TW109141896A patent/TWI820361B/zh active
- 2020-11-27 PE PE2022000837A patent/PE20221410A1/es unknown
- 2020-11-27 JP JP2022531056A patent/JP2023505067A/ja active Pending
- 2020-11-27 EP EP20893963.7A patent/EP4085918A4/en active Pending
- 2020-11-27 IL IL293364A patent/IL293364A/en unknown
- 2020-11-27 US US17/780,364 patent/US11639383B2/en active Active
- 2020-11-27 AU AU2020392166A patent/AU2020392166A1/en active Pending
-
2022
- 2022-05-12 KR KR1020220058317A patent/KR20220066873A/ko not_active Application Discontinuation
- 2022-05-26 CL CL2022001382A patent/CL2022001382A1/es unknown
- 2022-06-23 ZA ZA2022/06994A patent/ZA202206994B/en unknown
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2023
- 2023-03-01 US US18/176,934 patent/US20230257459A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
EP4085918A4 (en) | 2024-01-10 |
AU2020392166A1 (en) | 2022-05-26 |
PE20221410A1 (es) | 2022-09-20 |
KR102400253B9 (ko) | 2022-12-05 |
US20220403019A1 (en) | 2022-12-22 |
EP4085918A1 (en) | 2022-11-09 |
CL2022001382A1 (es) | 2023-02-24 |
TWI820361B (zh) | 2023-11-01 |
MX2022006426A (es) | 2022-06-22 |
KR20220066873A (ko) | 2022-05-24 |
WO2021107689A1 (ko) | 2021-06-03 |
JP2023505067A (ja) | 2023-02-08 |
KR102400253B1 (ko) | 2022-05-23 |
IL293364A (en) | 2022-07-01 |
US11639383B2 (en) | 2023-05-02 |
KR20210065887A (ko) | 2021-06-04 |
TW202134287A (zh) | 2021-09-16 |
ZA202206994B (en) | 2023-11-29 |
US20230257459A1 (en) | 2023-08-17 |
CN114786701A (zh) | 2022-07-22 |
CA3161303A1 (en) | 2021-06-03 |
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