BR112021020225A2 - Métodos de terapia antitumoral - Google Patents
Métodos de terapia antitumoralInfo
- Publication number
- BR112021020225A2 BR112021020225A2 BR112021020225A BR112021020225A BR112021020225A2 BR 112021020225 A2 BR112021020225 A2 BR 112021020225A2 BR 112021020225 A BR112021020225 A BR 112021020225A BR 112021020225 A BR112021020225 A BR 112021020225A BR 112021020225 A2 BR112021020225 A2 BR 112021020225A2
- Authority
- BR
- Brazil
- Prior art keywords
- antitumor therapy
- therapy methods
- antagonist
- individual
- effective dose
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 230000000259 anti-tumor effect Effects 0.000 title abstract 2
- 238000002560 therapeutic procedure Methods 0.000 title abstract 2
- 229940076838 Immune checkpoint inhibitor Drugs 0.000 abstract 2
- 108091008026 Inhibitory immune checkpoint proteins Proteins 0.000 abstract 2
- 102000037984 Inhibitory immune checkpoint proteins Human genes 0.000 abstract 2
- 239000012274 immune-checkpoint protein inhibitor Substances 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 229940124060 PD-1 antagonist Drugs 0.000 abstract 1
- 229940123751 PD-L1 antagonist Drugs 0.000 abstract 1
- 210000002889 endothelial cell Anatomy 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/191—Tumor necrosis factors [TNF], e.g. lymphotoxin [LT], i.e. TNF-beta
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
métodos de terapia antitumoral. a descrição provê métodos para o tratamento de um tumor em um indivíduo necessitando de tal tratamento compreendendo a administração ao indivíduo a combinação de uma dose efetiva de um vetor compreendendo um gene quimera fas ligado operacionalmente a um promotor específico para célula endotelial e uma dose efetiva de um inibidor de ponto de verificação imunológico. em alguns aspectos da descrição, o inibidor de ponto de verificação imunológico é um antagonista de pd-1 ou antagonista de pd-l1.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201962833402P | 2019-04-12 | 2019-04-12 | |
PCT/IB2020/053477 WO2020208612A1 (en) | 2019-04-12 | 2020-04-13 | Methods of anti-tumor therapy |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112021020225A2 true BR112021020225A2 (pt) | 2021-12-07 |
Family
ID=70333996
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112021020225A BR112021020225A2 (pt) | 2019-04-12 | 2020-04-13 | Métodos de terapia antitumoral |
Country Status (13)
Country | Link |
---|---|
US (1) | US20220185891A1 (pt) |
EP (1) | EP3952903A1 (pt) |
JP (1) | JP2022528425A (pt) |
KR (1) | KR20210152504A (pt) |
CN (1) | CN113710265A (pt) |
AU (1) | AU2020271998A1 (pt) |
BR (1) | BR112021020225A2 (pt) |
CA (1) | CA3134080A1 (pt) |
EA (1) | EA202192800A1 (pt) |
IL (1) | IL287135A (pt) |
MX (1) | MX2021012398A (pt) |
SG (1) | SG11202109441UA (pt) |
WO (1) | WO2020208612A1 (pt) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2023245249A1 (en) * | 2022-06-22 | 2023-12-28 | Race Oncology Ltd | Treatment of melanoma |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8039261B2 (en) | 2000-11-17 | 2011-10-18 | Vascular Biogenics Ltd. | Promoters exhibiting endothelial cell specificity and methods of using same for regulation of angiogenesis |
US20100282634A1 (en) | 2000-11-17 | 2010-11-11 | Dror Harats | Promoters Exhibiting Endothelial Cell Specificity and Methods of Using Same for Regulation of Angiogenesis |
AU2003222427B8 (en) | 2000-11-17 | 2010-04-29 | Vascular Biogenics Ltd. | Promoters exhibiting endothelial cell specificity and methods of using same |
US8071740B2 (en) | 2000-11-17 | 2011-12-06 | Vascular Biogenics Ltd. | Promoters exhibiting endothelial cell specificity and methods of using same for regulation of angiogenesis |
US20070286845A1 (en) | 2000-11-17 | 2007-12-13 | Vascular Biogenics Ltd. | Promoters exhibiting endothelial cell specificity and methods of using same for regulation of angiogenesis |
CN109485727A (zh) | 2005-05-09 | 2019-03-19 | 小野药品工业株式会社 | 程序性死亡-1(pd-1)的人单克隆抗体及使用抗pd-1抗体来治疗癌症的方法 |
MX2007015942A (es) | 2005-07-01 | 2008-03-07 | Medarex Inc | Anticuerpos monoclonales humanos para ligandos 1 (pd-l1) de muerte programada. |
DK2170959T3 (da) | 2007-06-18 | 2014-01-13 | Merck Sharp & Dohme | Antistoffer mod human programmeret dødsreceptor pd-1 |
TWI686405B (zh) | 2008-12-09 | 2020-03-01 | 建南德克公司 | 抗pd-l1抗體及其於增進t細胞功能之用途 |
RS60033B1 (sr) | 2009-11-24 | 2020-04-30 | Medimmune Ltd | Ciljano vezujući agensi usmereni na b7-h1 |
JP6196040B2 (ja) | 2010-01-05 | 2017-09-13 | バスキュラー バイオジェニックス リミテッド | 特異的な抗血管形成アデノウイルス剤の使用法 |
SG10201500048SA (en) | 2010-01-05 | 2015-03-30 | Vascular Biogenics Ltd | Compositions and methods for treating glioblastoma gbm |
CN103261298B (zh) | 2010-10-18 | 2014-07-16 | 道达尔研究技术弗吕公司 | 能膨胀的乙烯基芳族聚合物 |
BR112014012819B1 (pt) | 2011-11-28 | 2022-08-16 | Merck Patent Gmbh | Anticorpo anti-pd-l1 ou fragmento de ligação ao antígeno do mesmo e composição |
US9212224B2 (en) | 2012-05-15 | 2015-12-15 | Bristol-Myers Squibb Company | Antibodies that bind PD-L1 and uses thereof |
SG11201502941VA (en) * | 2012-10-17 | 2015-05-28 | Vascular Biogenics Ltd | Treatment methods using adenovirus |
TWI681969B (zh) | 2014-01-23 | 2020-01-11 | 美商再生元醫藥公司 | 針對pd-1的人類抗體 |
EP3161003A2 (en) * | 2014-06-27 | 2017-05-03 | Apogenix GmbH | Combination of cd95/cd95l inhibition and cancer immunotherapy |
US20190185571A1 (en) * | 2016-07-28 | 2019-06-20 | Musc Foundation For Research Development | Methods and compositions for the treatment of cancer combining an anti-smic antibody and immune checkpoint inhibitors |
-
2020
- 2020-04-13 KR KR1020217036097A patent/KR20210152504A/ko unknown
- 2020-04-13 JP JP2021559327A patent/JP2022528425A/ja active Pending
- 2020-04-13 WO PCT/IB2020/053477 patent/WO2020208612A1/en unknown
- 2020-04-13 BR BR112021020225A patent/BR112021020225A2/pt not_active Application Discontinuation
- 2020-04-13 MX MX2021012398A patent/MX2021012398A/es unknown
- 2020-04-13 AU AU2020271998A patent/AU2020271998A1/en not_active Abandoned
- 2020-04-13 EA EA202192800A patent/EA202192800A1/ru unknown
- 2020-04-13 EP EP20720524.6A patent/EP3952903A1/en not_active Withdrawn
- 2020-04-13 CA CA3134080A patent/CA3134080A1/en active Pending
- 2020-04-13 CN CN202080028041.5A patent/CN113710265A/zh active Pending
- 2020-04-13 SG SG11202109441UA patent/SG11202109441UA/en unknown
- 2020-04-13 US US17/602,963 patent/US20220185891A1/en active Pending
-
2021
- 2021-10-10 IL IL287135A patent/IL287135A/en unknown
Also Published As
Publication number | Publication date |
---|---|
CN113710265A (zh) | 2021-11-26 |
AU2020271998A1 (en) | 2021-09-30 |
JP2022528425A (ja) | 2022-06-10 |
US20220185891A1 (en) | 2022-06-16 |
IL287135A (en) | 2021-12-01 |
EA202192800A1 (ru) | 2022-03-30 |
EP3952903A1 (en) | 2022-02-16 |
KR20210152504A (ko) | 2021-12-15 |
CA3134080A1 (en) | 2020-10-15 |
SG11202109441UA (en) | 2021-09-29 |
MX2021012398A (es) | 2021-11-12 |
WO2020208612A1 (en) | 2020-10-15 |
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Legal Events
Date | Code | Title | Description |
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B11A | Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing | ||
B11Y | Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette] |