EA202192800A1 - Способы противоопухолевой терапии - Google Patents
Способы противоопухолевой терапииInfo
- Publication number
- EA202192800A1 EA202192800A1 EA202192800A EA202192800A EA202192800A1 EA 202192800 A1 EA202192800 A1 EA 202192800A1 EA 202192800 A EA202192800 A EA 202192800A EA 202192800 A EA202192800 A EA 202192800A EA 202192800 A1 EA202192800 A1 EA 202192800A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- methods
- antagonist
- subject
- effective dose
- checkpoint inhibitor
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/191—Tumor necrosis factors [TNF], e.g. lymphotoxin [LT], i.e. TNF-beta
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Gastroenterology & Hepatology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
Изобретение относится к способам лечения опухоли у нуждающегося в этом субъекта, предусматривающим введение субъекту комбинации эффективной дозы вектора, содержащего ген химерного белка на основе Fas, функционально связанный с промотором, специфическим в отношении эндотелиальных клеток, и эффективной дозы ингибитора контрольной точки иммунного ответа. Согласно некоторым аспектам настоящего раскрытия ингибитор контрольной точки иммунного ответа представляет собой антагонист PD-1 или антагонист PD-L1.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201962833402P | 2019-04-12 | 2019-04-12 | |
PCT/IB2020/053477 WO2020208612A1 (en) | 2019-04-12 | 2020-04-13 | Methods of anti-tumor therapy |
Publications (1)
Publication Number | Publication Date |
---|---|
EA202192800A1 true EA202192800A1 (ru) | 2022-03-30 |
Family
ID=70333996
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA202192800A EA202192800A1 (ru) | 2019-04-12 | 2020-04-13 | Способы противоопухолевой терапии |
Country Status (13)
Country | Link |
---|---|
US (1) | US20220185891A1 (ru) |
EP (1) | EP3952903A1 (ru) |
JP (1) | JP2022528425A (ru) |
KR (1) | KR20210152504A (ru) |
CN (1) | CN113710265A (ru) |
AU (1) | AU2020271998A1 (ru) |
BR (1) | BR112021020225A2 (ru) |
CA (1) | CA3134080A1 (ru) |
EA (1) | EA202192800A1 (ru) |
IL (1) | IL287135A (ru) |
MX (1) | MX2021012398A (ru) |
SG (1) | SG11202109441UA (ru) |
WO (1) | WO2020208612A1 (ru) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2023245248A1 (en) * | 2022-06-22 | 2023-12-28 | Race Oncology Ltd | Treatment of melanoma |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8039261B2 (en) | 2000-11-17 | 2011-10-18 | Vascular Biogenics Ltd. | Promoters exhibiting endothelial cell specificity and methods of using same for regulation of angiogenesis |
US8071740B2 (en) | 2000-11-17 | 2011-12-06 | Vascular Biogenics Ltd. | Promoters exhibiting endothelial cell specificity and methods of using same for regulation of angiogenesis |
AU2003222427B8 (en) | 2000-11-17 | 2010-04-29 | Vascular Biogenics Ltd. | Promoters exhibiting endothelial cell specificity and methods of using same |
US20070286845A1 (en) | 2000-11-17 | 2007-12-13 | Vascular Biogenics Ltd. | Promoters exhibiting endothelial cell specificity and methods of using same for regulation of angiogenesis |
US20100282634A1 (en) | 2000-11-17 | 2010-11-11 | Dror Harats | Promoters Exhibiting Endothelial Cell Specificity and Methods of Using Same for Regulation of Angiogenesis |
SI2161336T1 (sl) | 2005-05-09 | 2013-11-29 | Ono Pharmaceutical Co., Ltd. | Humana monoklonska protitelesa za programirano smrt 1 (PD-1) in postopki za zdravljenje raka ob uporabi anti-PD-1 protiteles samih ali v kombinaciji z drugimi imunoterapevtiki |
BRPI0613361A2 (pt) | 2005-07-01 | 2011-01-04 | Medarex Inc | anticorpo monoclonal humano isolado, composição, imunoconjugado, molécula biespecìfica, molécula de ácido nucleico isolada, vetor de expressão, célula hospedeira, camundongo transgênico, método para modular uma resposta imune num indivìduo, método para inibir crescimento de células tumorais num indivìduo, método para tratar uma doença infecciosa num indivìduo, método para aumentar uma resposta imune a um antìgeno num indivìduo, método para tratar ou prevenir uma doença inflamatória num indivìduo e método para preparar o anticorpo anti-pd-l1 |
EP2535354B1 (en) | 2007-06-18 | 2017-01-11 | Merck Sharp & Dohme B.V. | Antibodies to human programmed death receptor pd-1 |
KR20210060670A (ko) | 2008-12-09 | 2021-05-26 | 제넨테크, 인크. | 항-pd-l1 항체 및 t 세포 기능을 향상시키기 위한 그의 용도 |
BR122021025338B1 (pt) | 2009-11-24 | 2023-03-14 | Medimmune Limited | Anticorpo isolado ou fragmento de ligação do mesmo contra b7-h1, composição farmacêutica e seus usos |
WO2011083464A2 (en) | 2010-01-05 | 2011-07-14 | Vascular Biogenics Ltd. | Methods for use of a specific anti-angiogenic adenoviral agent |
AU2011204407B2 (en) | 2010-01-05 | 2015-05-07 | Vascular Biogenics Ltd. | Compositions and methods for treating glioblastoma GBM |
EA022941B1 (ru) | 2010-10-18 | 2016-03-31 | Тотал Ресерч Энд Текнолоджи Фелюи | Способ увеличения индекса текучести расплава вспениваемого винилароматического полимера |
HUE051954T2 (hu) | 2011-11-28 | 2021-03-29 | Merck Patent Gmbh | ANTI-PD-L1 ellenanyagok és alkalmazásaik |
US9856320B2 (en) | 2012-05-15 | 2018-01-02 | Bristol-Myers Squibb Company | Cancer immunotherapy by disrupting PD-1/PD-L1 signaling |
NZ707336A (en) * | 2012-10-17 | 2019-01-25 | Vascular Biogenics Ltd | Treatment methods using adenovirus |
TWI681969B (zh) | 2014-01-23 | 2020-01-11 | 美商再生元醫藥公司 | 針對pd-1的人類抗體 |
WO2015197874A2 (en) * | 2014-06-27 | 2015-12-30 | Apogenix Gmbh | Combination of cd95/cd95l inhibition and cancer immunotherapy |
US20190185571A1 (en) * | 2016-07-28 | 2019-06-20 | Musc Foundation For Research Development | Methods and compositions for the treatment of cancer combining an anti-smic antibody and immune checkpoint inhibitors |
-
2020
- 2020-04-13 WO PCT/IB2020/053477 patent/WO2020208612A1/en unknown
- 2020-04-13 BR BR112021020225A patent/BR112021020225A2/pt not_active Application Discontinuation
- 2020-04-13 CN CN202080028041.5A patent/CN113710265A/zh active Pending
- 2020-04-13 AU AU2020271998A patent/AU2020271998A1/en not_active Abandoned
- 2020-04-13 SG SG11202109441UA patent/SG11202109441UA/en unknown
- 2020-04-13 CA CA3134080A patent/CA3134080A1/en active Pending
- 2020-04-13 US US17/602,963 patent/US20220185891A1/en active Pending
- 2020-04-13 KR KR1020217036097A patent/KR20210152504A/ko unknown
- 2020-04-13 MX MX2021012398A patent/MX2021012398A/es unknown
- 2020-04-13 EA EA202192800A patent/EA202192800A1/ru unknown
- 2020-04-13 JP JP2021559327A patent/JP2022528425A/ja active Pending
- 2020-04-13 EP EP20720524.6A patent/EP3952903A1/en not_active Withdrawn
-
2021
- 2021-10-10 IL IL287135A patent/IL287135A/en unknown
Also Published As
Publication number | Publication date |
---|---|
EP3952903A1 (en) | 2022-02-16 |
KR20210152504A (ko) | 2021-12-15 |
WO2020208612A1 (en) | 2020-10-15 |
IL287135A (en) | 2021-12-01 |
MX2021012398A (es) | 2021-11-12 |
BR112021020225A2 (pt) | 2021-12-07 |
JP2022528425A (ja) | 2022-06-10 |
US20220185891A1 (en) | 2022-06-16 |
SG11202109441UA (en) | 2021-09-29 |
AU2020271998A1 (en) | 2021-09-30 |
CA3134080A1 (en) | 2020-10-15 |
CN113710265A (zh) | 2021-11-26 |
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