BR0213224A - agente de ligação especìfico, hibridoma, conjugado, molécula de ácido nucleico, vetor, célula hospedeira, métodos de fabricar um agente de ligação especìfico, de fabricar um anticorpo, de unibir a angiogênese indesejada em um mamìfero e de tratar cáncer em um mamìfero, composição farmacêutica, métodos de modular ou inibir a atividade da angiopoietina-2, de modular pelo menos um dentre a permeabilidade vascular ou o vazamento de plasma em um mamìfero, de tratar doença e de detectar o nìvel de angiopoietina-2 em uma amostra biológica, e, anticorpo - Google Patents

agente de ligação especìfico, hibridoma, conjugado, molécula de ácido nucleico, vetor, célula hospedeira, métodos de fabricar um agente de ligação especìfico, de fabricar um anticorpo, de unibir a angiogênese indesejada em um mamìfero e de tratar cáncer em um mamìfero, composição farmacêutica, métodos de modular ou inibir a atividade da angiopoietina-2, de modular pelo menos um dentre a permeabilidade vascular ou o vazamento de plasma em um mamìfero, de tratar doença e de detectar o nìvel de angiopoietina-2 em uma amostra biológica, e, anticorpo

Info

Publication number
BR0213224A
BR0213224A BRPI0213224-9A BR0213224A BR0213224A BR 0213224 A BR0213224 A BR 0213224A BR 0213224 A BR0213224 A BR 0213224A BR 0213224 A BR0213224 A BR 0213224A
Authority
BR
Brazil
Prior art keywords
mammal
specific binding
modulating
making
binding agent
Prior art date
Application number
BRPI0213224-9A
Other languages
English (en)
Inventor
Jonathan Daniel Oliner
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of BR0213224A publication Critical patent/BR0213224A/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/515—Angiogenesic factors; Angiogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Genetics & Genomics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Vascular Medicine (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Toxicology (AREA)
  • Emergency Medicine (AREA)
  • Oncology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Zoology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Urology & Nephrology (AREA)
  • Gastroenterology & Hepatology (AREA)

Abstract

"AGENTE DE LIGAçãO ESPECìFICO, HIBRIDOMA, CONJUGADO, MOLéCULA DE áCIDO NUCLEICO, VETOR, CéLULA HOSPEDEIRA, METODOS DE FABRICAR UM AGENTE DE LIGAçãO ESPECìFICO, DE FABRICAR UM ANTICORPO, DE INIBIR A ANGIOGêNESE INDESEJADA EM UM MAMìFERO E DE TRATAR CáNCER EM UM MAMìFERO, COMPOSIçãO FARMACêUTICA, MéTODOS DE MODULAR OU INIBIR A ATIVIDADE DA ANGIOPOIETINA-2, DE MODULAR PELO MENOS UM DENTRE A PERMEABILIDADE VASCULAR OU O VAZAMENTO DE PLASMA EM UM MAMìFERO, DE TRATAR DOENçA E DE DETECTAR O NìVEL DE ANGIOPOIETINA-2 EM UMA AMOSTRA BIOLOGICA, E, ANTICORPO". São divulgados agentes de ligação específicos, tais como anticorpos completamente humanos, que se ligam à angiopoietina-2. Também são divulgados fragmentos de cadeia pesada, fragmentos de cadeia leve e CDRs dos anticorpos, assim como métodos de fabricar e usar os anticorpos.
BRPI0213224-9A 2001-10-11 2002-10-11 agente de ligação especìfico, hibridoma, conjugado, molécula de ácido nucleico, vetor, célula hospedeira, métodos de fabricar um agente de ligação especìfico, de fabricar um anticorpo, de unibir a angiogênese indesejada em um mamìfero e de tratar cáncer em um mamìfero, composição farmacêutica, métodos de modular ou inibir a atividade da angiopoietina-2, de modular pelo menos um dentre a permeabilidade vascular ou o vazamento de plasma em um mamìfero, de tratar doença e de detectar o nìvel de angiopoietina-2 em uma amostra biológica, e, anticorpo BR0213224A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US32860401P 2001-10-11 2001-10-11
US10/269,805 US7521053B2 (en) 2001-10-11 2002-10-10 Angiopoietin-2 specific binding agents
PCT/US2002/032613 WO2003030833A2 (en) 2001-10-11 2002-10-11 Angiopoietin-2 specific binding agents

Publications (1)

Publication Number Publication Date
BR0213224A true BR0213224A (pt) 2007-03-27

Family

ID=26953906

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0213224-9A BR0213224A (pt) 2001-10-11 2002-10-11 agente de ligação especìfico, hibridoma, conjugado, molécula de ácido nucleico, vetor, célula hospedeira, métodos de fabricar um agente de ligação especìfico, de fabricar um anticorpo, de unibir a angiogênese indesejada em um mamìfero e de tratar cáncer em um mamìfero, composição farmacêutica, métodos de modular ou inibir a atividade da angiopoietina-2, de modular pelo menos um dentre a permeabilidade vascular ou o vazamento de plasma em um mamìfero, de tratar doença e de detectar o nìvel de angiopoietina-2 em uma amostra biológica, e, anticorpo

Country Status (23)

Country Link
US (1) US7521053B2 (pt)
EP (2) EP2272869B1 (pt)
JP (3) JP4637480B2 (pt)
KR (2) KR101089844B1 (pt)
CN (2) CN100595211C (pt)
AU (2) AU2002343498B2 (pt)
BR (1) BR0213224A (pt)
CA (1) CA2461435A1 (pt)
CY (1) CY1112993T1 (pt)
DK (1) DK1495053T3 (pt)
EA (1) EA010726B1 (pt)
ES (2) ES2439221T3 (pt)
HK (2) HK1072775A1 (pt)
HU (1) HUP0500994A3 (pt)
IL (2) IL161021A0 (pt)
MX (1) MXPA04003345A (pt)
NO (1) NO332593B1 (pt)
NZ (2) NZ575673A (pt)
PL (1) PL373911A1 (pt)
PT (1) PT1495053E (pt)
RS (1) RS51437B (pt)
SI (1) SI1495053T1 (pt)
WO (1) WO2003030833A2 (pt)

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