BR0115715A - Análise de expressão de ácidos nucleìcos e polipeptìdeos úteis na diagnose e tratamento de câncer da próstata - Google Patents
Análise de expressão de ácidos nucleìcos e polipeptìdeos úteis na diagnose e tratamento de câncer da próstataInfo
- Publication number
- BR0115715A BR0115715A BR0115715-9A BR0115715A BR0115715A BR 0115715 A BR0115715 A BR 0115715A BR 0115715 A BR0115715 A BR 0115715A BR 0115715 A BR0115715 A BR 0115715A
- Authority
- BR
- Brazil
- Prior art keywords
- prostate cancer
- treatment
- nucleic acid
- expression analysis
- cancer diagnosis
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57407—Specifically defined cancers
- G01N33/57434—Specifically defined cancers of prostate
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
- G01N33/9493—Immunosupressants
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2565/00—Nucleic acid analysis characterised by mode or means of detection
- C12Q2565/50—Detection characterised by immobilisation to a surface
- C12Q2565/501—Detection characterised by immobilisation to a surface being an array of oligonucleotides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Urology & Nephrology (AREA)
- Pathology (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Analytical Chemistry (AREA)
- Hematology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Hospice & Palliative Care (AREA)
- Biophysics (AREA)
- General Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Cell Biology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
"ANáLISE DE EXPRESSãO DE áCIDOS NUCLéICOS E POLIPEPTìDEOS úTEIS NA DIAGNOSE E TRATAMENTO DE CâNCER DA PRóSTATA". A invenção diz respeito a composições, kits e métodos para detectar, caracterizar, prevenir e tratar o câncer da próstata. Marcadores de FKBP são fornecidos, em que as mudanças nos níveis de expressão de um ou mais dos marcadores de FKBP são correlacionadas com a presença de câncer da próstata.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US25353900P | 2000-11-28 | 2000-11-28 | |
PCT/US2001/044536 WO2002044418A2 (en) | 2000-11-28 | 2001-11-28 | Expression analysis of fkbp nucleic acids and polypeptides useful in the diagnosis and treatment of prostate cancer |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0115715A true BR0115715A (pt) | 2004-02-03 |
Family
ID=22960688
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0115715-9A BR0115715A (pt) | 2000-11-28 | 2001-11-28 | Análise de expressão de ácidos nucleìcos e polipeptìdeos úteis na diagnose e tratamento de câncer da próstata |
Country Status (14)
Country | Link |
---|---|
US (3) | US6821731B2 (pt) |
EP (2) | EP1356108A2 (pt) |
JP (4) | JP2004526425A (pt) |
AU (1) | AU2002241524A1 (pt) |
BR (1) | BR0115715A (pt) |
CA (1) | CA2429722A1 (pt) |
HU (1) | HUP0303888A3 (pt) |
IL (1) | IL155952A0 (pt) |
MX (1) | MXPA03004688A (pt) |
NO (1) | NO20032395L (pt) |
NZ (1) | NZ526708A (pt) |
PL (1) | PL365605A1 (pt) |
WO (1) | WO2002044418A2 (pt) |
ZA (1) | ZA200304996B (pt) |
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE427948T1 (de) * | 2001-04-24 | 2009-04-15 | Purdue Research Foundation | Folat-mimetika und deren folatrezeptorbindende konjugate |
US7745180B2 (en) * | 2002-04-24 | 2010-06-29 | Hitachi Chemical Co., Ltd. | Device and method for high-throughput quantification of mRNA from whole blood |
US7655397B2 (en) * | 2002-04-25 | 2010-02-02 | The United States Of America As Represented By The Department Of Health And Human Services | Selections of genes and methods of using the same for diagnosis and for targeting the therapy of select cancers |
US7774143B2 (en) * | 2002-04-25 | 2010-08-10 | The United States Of America As Represented By The Secretary, Department Of Health And Human Services | Methods for analyzing high dimensional data for classifying, diagnosing, prognosticating, and/or predicting diseases and other biological states |
CA2484640C (en) * | 2002-05-15 | 2012-01-17 | Endocyte, Inc. | Vitamin-mitomycin conjugates |
US20050042621A1 (en) * | 2002-09-27 | 2005-02-24 | Affymetrix, Inc. | Method for preparing a nucleic acid sample for hybridization to an array |
WO2004069159A2 (en) | 2003-01-27 | 2004-08-19 | Endocyte, Inc. | Vitamin receptor binding drug delivery conjugates |
WO2006012527A1 (en) | 2004-07-23 | 2006-02-02 | Endocyte, Inc. | Bivalent linkers and conjugates thereof |
JP5289935B2 (ja) | 2005-03-16 | 2013-09-11 | エンドサイト,インコーポレイテッド | プテロイン酸およびその結合体の合成と精製 |
US20080280937A1 (en) * | 2005-08-19 | 2008-11-13 | Christopher Paul Leamon | Ligand Conjugates of Vinca Alkaloids, Analogs, and Derivatives |
ES2468240T3 (es) | 2005-08-19 | 2014-06-16 | Endocyte, Inc. | Conjugados de ligando de múltiples fármacos |
GB0611405D0 (en) | 2006-06-09 | 2006-07-19 | Univ Belfast | FKBP-L: A novel inhibitor of angiogenesis |
WO2008101231A2 (en) | 2007-02-16 | 2008-08-21 | Endocyte, Inc. | Methods and compositions for treating and diagnosing kidney disease |
CN101678124A (zh) * | 2007-03-14 | 2010-03-24 | 恩多塞特公司 | 结合配体连接的微管溶素递药缀合物 |
US9877965B2 (en) | 2007-06-25 | 2018-01-30 | Endocyte, Inc. | Vitamin receptor drug delivery conjugates for treating inflammation |
EP3569251A1 (en) | 2007-06-25 | 2019-11-20 | Endocyte, Inc. | Conjugates containing hydrophilic spacer linkers |
CA2703491C (en) | 2007-10-25 | 2017-06-13 | Endocyte, Inc. | Tubulysins and processes for preparing |
US11179361B2 (en) | 2008-08-08 | 2021-11-23 | City Of Hope | Methods of quantifying N2-(1-carboxyethyl)-2′-deoxy-guanosine (CEdG) and synthesis of oligonucleotides containing CEdG |
US20100102218A1 (en) * | 2008-08-08 | 2010-04-29 | Samuel Rahbar | METHODS OF QUANTIFYING N2-(1-CARBOXYETHYL)-2'-DEOXY-GUANOSINE (CEdG) AND SYNTHESIS OF OLIGONUCLEOTIDES CONTAINING CEdG |
CN102549438B (zh) * | 2009-09-24 | 2014-10-29 | 国家健康与医学研究院 | Fkbp52-tau相互作用作为新颖治疗靶点用于治疗涉及tau机能失调的神经障碍 |
US10080805B2 (en) | 2012-02-24 | 2018-09-25 | Purdue Research Foundation | Cholecystokinin B receptor targeting for imaging and therapy |
US20140080175A1 (en) | 2012-03-29 | 2014-03-20 | Endocyte, Inc. | Processes for preparing tubulysin derivatives and conjugates thereof |
AU2013331440A1 (en) | 2012-10-16 | 2015-04-30 | Endocyte, Inc. | Drug delivery conjugates containing unnatural amino acids and methods for using |
GB201322034D0 (en) | 2013-12-12 | 2014-01-29 | Almac Diagnostics Ltd | Prostate cancer classification |
US10155935B2 (en) * | 2014-03-12 | 2018-12-18 | Novozymes A/S | Polypeptides with lipase activity and polynucleotides encoding same |
JP6755264B2 (ja) | 2015-05-18 | 2020-09-16 | コーセプト セラピューティクス, インコーポレイテッド | クッシング症候群についての処置を診断および評価するための方法 |
WO2019152728A1 (en) | 2018-02-02 | 2019-08-08 | City Of Hope | Methods of quantifying methylglyoxal-induced nucleic acid adducts |
Family Cites Families (89)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4873191A (en) | 1981-06-12 | 1989-10-10 | Ohio University | Genetic transformation of zygotes |
US4522811A (en) | 1982-07-08 | 1985-06-11 | Syntex (U.S.A.) Inc. | Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides |
US4870009A (en) | 1982-11-22 | 1989-09-26 | The Salk Institute For Biological Studies | Method of obtaining gene product through the generation of transgenic animals |
US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
US4736866B1 (en) | 1984-06-22 | 1988-04-12 | Transgenic non-human mammals | |
JPS6147500A (ja) | 1984-08-15 | 1986-03-07 | Res Dev Corp Of Japan | キメラモノクロ−ナル抗体及びその製造法 |
EP0173494A3 (en) | 1984-08-27 | 1987-11-25 | The Board Of Trustees Of The Leland Stanford Junior University | Chimeric receptors by dna splicing and expression |
GB8422238D0 (en) | 1984-09-03 | 1984-10-10 | Neuberger M S | Chimeric proteins |
JPS61134325A (ja) | 1984-12-04 | 1986-06-21 | Teijin Ltd | ハイブリツド抗体遺伝子の発現方法 |
US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
US5225539A (en) | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
US5030559A (en) | 1986-04-01 | 1991-07-09 | Board Of Regents, The University Of Texas System | Methods and compositions for the identification of metastatic human tumors |
DE122007000007I1 (de) | 1986-04-09 | 2007-05-16 | Genzyme Corp | Genetisch transformierte Tiere, die ein gewünschtes Protein in Milch absondern |
US4902505A (en) | 1986-07-30 | 1990-02-20 | Alkermes | Chimeric peptides for neuropeptide delivery through the blood-brain barrier |
US5116742A (en) | 1986-12-03 | 1992-05-26 | University Patents, Inc. | RNA ribozyme restriction endoribonucleases and methods |
US4987071A (en) | 1986-12-03 | 1991-01-22 | University Patents, Inc. | RNA ribozyme polymerases, dephosphorylases, restriction endoribonucleases and methods |
US4904582A (en) | 1987-06-11 | 1990-02-27 | Synthetic Genetics | Novel amphiphilic nucleic acid conjugates |
US4873316A (en) | 1987-06-23 | 1989-10-10 | Biogen, Inc. | Isolation of exogenous recombinant proteins from the milk of transgenic mammals |
US5162504A (en) | 1988-06-03 | 1992-11-10 | Cytogen Corporation | Monoclonal antibodies to a new antigenic marker in epithelial prostatic cells and serum of prostatic cancer patients |
US5118611A (en) | 1988-07-25 | 1992-06-02 | Adeza Biomedical Corporation | Adenocarcinoma antigen binding methods and reagents |
US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
WO1990002809A1 (en) | 1988-09-02 | 1990-03-22 | Protein Engineering Corporation | Generation and selection of recombinant varied binding proteins |
FR2646438B1 (fr) | 1989-03-20 | 2007-11-02 | Pasteur Institut | Procede de remplacement specifique d'une copie d'un gene present dans le genome receveur par l'integration d'un gene different de celui ou se fait l'integration |
US5328470A (en) | 1989-03-31 | 1994-07-12 | The Regents Of The University Of Michigan | Treatment of diseases by site-specific instillation of cells or site-specific transformation of cells and kits therefor |
US5459039A (en) | 1989-05-12 | 1995-10-17 | Duke University | Methods for mapping genetic mutations |
EP0437576B1 (en) | 1989-07-25 | 2002-07-03 | Cell Genesys, Inc. | Homologous recombination for universal donor cells and chimeric mammalian hosts |
US5427908A (en) | 1990-05-01 | 1995-06-27 | Affymax Technologies N.V. | Recombinant library screening methods |
GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
CA2109602C (en) | 1990-07-10 | 2002-10-01 | Gregory P. Winter | Methods for producing members of specific binding pairs |
US5393788A (en) | 1990-07-10 | 1995-02-28 | Smithkline Beecham Corporation | Phenylalkyl oxamides |
US5633425A (en) | 1990-08-29 | 1997-05-27 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
EP0546073B1 (en) | 1990-08-29 | 1997-09-10 | GenPharm International, Inc. | production and use of transgenic non-human animals capable of producing heterologous antibodies |
US5625126A (en) | 1990-08-29 | 1997-04-29 | Genpharm International, Inc. | Transgenic non-human animals for producing heterologous antibodies |
US5545806A (en) | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
US5661016A (en) | 1990-08-29 | 1997-08-26 | Genpharm International Inc. | Transgenic non-human animals capable of producing heterologous antibodies of various isotypes |
EP0564531B1 (en) | 1990-12-03 | 1998-03-25 | Genentech, Inc. | Enrichment method for variant proteins with altered binding properties |
JP4146512B2 (ja) | 1991-03-01 | 2008-09-10 | ダイアックス コープ. | 小型タンパク質 |
DK1471142T3 (da) | 1991-04-10 | 2009-03-09 | Scripps Research Inst | Heterodimere receptor-biblioteker under anvendelse af fagemider |
DE4122599C2 (de) | 1991-07-08 | 1993-11-11 | Deutsches Krebsforsch | Phagemid zum Screenen von Antikörpern |
WO1993004169A1 (en) | 1991-08-20 | 1993-03-04 | Genpharm International, Inc. | Gene targeting in animal cells using isogenic dna constructs |
US5605930A (en) | 1991-10-21 | 1997-02-25 | The United States Of America As Represented By The Department Of Health And Human Services | Compositions and methods for treating and preventing pathologies including cancer |
US5965132A (en) | 1992-03-05 | 1999-10-12 | Board Of Regents, The University Of Texas System | Methods and compositions for targeting the vasculature of solid tumors |
US5428011A (en) | 1992-06-16 | 1995-06-27 | Procyon Biopharma, Inc. | Pharmaceutical preparations for inhibiting tumours associated with prostate adenocarcinoma |
US5674682A (en) | 1992-10-29 | 1997-10-07 | Thomas Jefferson University | Nucleic acid primers for detecting micrometastasis of prostate cancer |
CA2153387A1 (en) | 1993-01-07 | 1994-07-21 | Hubert Koester | Dna sequencing by mass spectrometry |
US5869337A (en) | 1993-02-12 | 1999-02-09 | President And Fellows Of Harvard College | Regulated transcription of targeted genes and other biological events |
US5723302A (en) | 1993-05-14 | 1998-03-03 | Nordion International Inc. | Detection of prostate-specific antigen in breast tumors |
GB9309966D0 (en) | 1993-05-14 | 1993-06-30 | Nordion Int Inc | Detection of prostrate-specific antigen in breast tumors |
US6479055B1 (en) | 1993-06-07 | 2002-11-12 | Trimeris, Inc. | Methods for inhibition of membrane fusion-associated events, including respiratory syncytial virus transmission |
US5498531A (en) | 1993-09-10 | 1996-03-12 | President And Fellows Of Harvard College | Intron-mediated recombinant techniques and reagents |
US5538848A (en) | 1994-11-16 | 1996-07-23 | Applied Biosystems Division, Perkin-Elmer Corp. | Method for detecting nucleic acid amplification using self-quenching fluorescence probe |
CN1046944C (zh) | 1993-12-17 | 1999-12-01 | 山道士有限公司 | 雷怕霉素类衍生物 |
IL112873A (en) | 1994-03-08 | 2005-03-20 | Wyeth Corp | Rapamycin-fkbp12 binding proteins, their isolation and their use |
WO1995028498A1 (en) | 1994-04-15 | 1995-10-26 | The Trustees Of Columbia University In The City Of New York | Method for molecular staging of prostate cancer |
US5362718A (en) | 1994-04-18 | 1994-11-08 | American Home Products Corporation | Rapamycin hydroxyesters |
US5856112A (en) | 1994-06-16 | 1999-01-05 | Urocor, Inc. | Method for selectively inducing biomarker expression in urologic tumor tissue for diagnosis and treatment thereof |
US5635197A (en) | 1995-03-21 | 1997-06-03 | Eli Lilly And Company | Treatment and prevention of prostatic cancer metastasis |
US5629007A (en) | 1995-03-21 | 1997-05-13 | Eli Lilly And Company | Method of preventing prostatic cancer development |
US5633161A (en) | 1995-03-29 | 1997-05-27 | Millennium Pharmaceuticals, Inc. | Murine gene fomy030 coding for tumor progression inhibitor |
US5968802A (en) | 1995-06-07 | 1999-10-19 | Wang; Bruce | Nuclear cyclophilin |
US5859031A (en) | 1995-06-07 | 1999-01-12 | Gpi Nil Holdings, Inc. | Small molecule inhibitors of rotamase enzyme activity |
RU2158267C2 (ru) | 1995-06-09 | 2000-10-27 | Новартис Аг | Производные рапамицина и фармацевтическая композиция на их основе |
WO1998004689A1 (en) | 1995-07-31 | 1998-02-05 | Urocor, Inc. | Biomarkers and targets for diagnosis, prognosis and management of prostate disease |
US5854206A (en) | 1995-08-25 | 1998-12-29 | Corixa Corporation | Compounds and methods for treatment and diagnosis of prostate cancer |
GB9517780D0 (en) | 1995-08-31 | 1995-11-01 | Roslin Inst Edinburgh | Biological manipulation |
GB9517779D0 (en) | 1995-08-31 | 1995-11-01 | Roslin Inst Edinburgh | Biological manipulation |
US5801197A (en) | 1995-10-31 | 1998-09-01 | Gpi Nil Holdings, Inc. | Rotamase enzyme activity inhibitors |
US5905027A (en) | 1995-12-27 | 1999-05-18 | Uab Research Foundation | Method of diagnosing and treating gliomas |
AU728186B2 (en) | 1996-03-15 | 2001-01-04 | Corixa Corporation | Compounds and methods for immunotherapy and immunodiagnosis of prostate cancer |
US5861248A (en) | 1996-03-29 | 1999-01-19 | Urocor, Inc. | Biomarkers for detection of prostate cancer |
US5976838A (en) | 1996-12-18 | 1999-11-02 | Genetics Institute, Inc. | Secreted proteins and polynucleotides encoding them |
WO1998037418A2 (en) | 1997-02-25 | 1998-08-27 | Corixa Corporation | Compounds for immunodiagnosis of prostate cancer and methods for their use |
NZ337446A (en) | 1997-02-25 | 2001-02-23 | Corixa Corp | Immunogenic portions of a prostate protein and their use in immunotherapy of prostate cancer and methods for their use |
EP0974652A4 (en) | 1997-04-08 | 2000-08-30 | Banyu Pharma Co Ltd | GENE ASSOCIATED WITH CANCER METASTASE |
AU9689398A (en) | 1997-10-07 | 1999-04-27 | Corixa Corporation | Compounds and methods for immunotherapy and immunodiagnosis of prostate cancer |
WO1999022773A2 (en) | 1997-11-05 | 1999-05-14 | Baylor College Of Medicine | Sequences for targeting metastatic cells |
US5945522A (en) | 1997-12-22 | 1999-08-31 | Genset | Prostate cancer gene |
US5972615A (en) | 1998-01-21 | 1999-10-26 | Urocor, Inc. | Biomarkers and targets for diagnosis, prognosis and management of prostate disease |
WO1999037811A1 (en) | 1998-01-21 | 1999-07-29 | Urocor, Inc. | Biomarkers and targets for diagnosis, prognosis and management of prostate disease |
EP0939084A1 (en) | 1998-02-11 | 1999-09-01 | Ramanath B. Rao | An estrogen binding proteinaceous substance, its possible role in estrogen action, and potential use. |
KR20010083111A (ko) | 1998-07-14 | 2001-08-31 | 길리스 스티브 | 전립선암의 치료 및 진단을 위한 조성물 및 방법 |
GB9815696D0 (en) | 1998-07-20 | 1998-09-16 | Pfizer Ltd | Heterocyclics |
AU5815699A (en) | 1998-09-08 | 2000-03-27 | Urocor, Inc. | Prostate specific promoter and regulation of gene expression |
US6251932B1 (en) | 1998-09-25 | 2001-06-26 | Asta Medica Ag | Immunophilin ligands |
JP2002531061A (ja) | 1998-09-30 | 2002-09-24 | ミレニアム ファーマシューティカルズ インク. | 前立腺癌の診断および治療において有用な特異的核酸およびポリペプチドの発現解析 |
AU3395900A (en) | 1999-03-12 | 2000-10-04 | Human Genome Sciences, Inc. | Human lung cancer associated gene sequences and polypeptides |
AU2002214576A1 (en) * | 2000-10-13 | 2002-04-22 | The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Genes related to development of refractory prostate cancer |
IT1395574B1 (it) | 2009-09-14 | 2012-10-16 | Guala Dispensing Spa | Dispositivo di erogazione |
-
2001
- 2001-11-28 US US09/997,423 patent/US6821731B2/en not_active Expired - Fee Related
- 2001-11-28 EP EP01988194A patent/EP1356108A2/en not_active Withdrawn
- 2001-11-28 WO PCT/US2001/044536 patent/WO2002044418A2/en active IP Right Grant
- 2001-11-28 JP JP2002546766A patent/JP2004526425A/ja not_active Withdrawn
- 2001-11-28 EP EP10183140A patent/EP2316976A1/en not_active Withdrawn
- 2001-11-28 AU AU2002241524A patent/AU2002241524A1/en not_active Abandoned
- 2001-11-28 NZ NZ526708A patent/NZ526708A/en unknown
- 2001-11-28 PL PL01365605A patent/PL365605A1/xx not_active Application Discontinuation
- 2001-11-28 MX MXPA03004688A patent/MXPA03004688A/es active IP Right Grant
- 2001-11-28 CA CA002429722A patent/CA2429722A1/en not_active Abandoned
- 2001-11-28 HU HU0303888A patent/HUP0303888A3/hu unknown
- 2001-11-28 BR BR0115715-9A patent/BR0115715A/pt not_active IP Right Cessation
- 2001-11-28 IL IL15595201A patent/IL155952A0/xx unknown
-
2003
- 2003-05-27 NO NO20032395A patent/NO20032395L/no unknown
- 2003-06-26 ZA ZA200304996A patent/ZA200304996B/en unknown
-
2004
- 2004-11-23 US US10/996,096 patent/US7402388B2/en not_active Expired - Fee Related
-
2008
- 2008-05-14 JP JP2008127055A patent/JP2008271979A/ja not_active Withdrawn
- 2008-07-03 US US12/217,450 patent/US20090062133A1/en not_active Abandoned
-
2009
- 2009-06-17 JP JP2009144509A patent/JP2009242417A/ja active Pending
-
2010
- 2010-07-30 JP JP2010172140A patent/JP2011043496A/ja not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
US7402388B2 (en) | 2008-07-22 |
PL365605A1 (en) | 2005-01-10 |
MXPA03004688A (es) | 2003-09-05 |
NO20032395L (no) | 2003-07-14 |
JP2009242417A (ja) | 2009-10-22 |
US20050069946A1 (en) | 2005-03-31 |
NO20032395D0 (no) | 2003-05-27 |
US6821731B2 (en) | 2004-11-23 |
NZ526708A (en) | 2005-07-29 |
JP2011043496A (ja) | 2011-03-03 |
EP2316976A1 (en) | 2011-05-04 |
HUP0303888A3 (en) | 2007-05-02 |
WO2002044418A3 (en) | 2003-08-21 |
AU2002241524A1 (en) | 2002-06-11 |
JP2004526425A (ja) | 2004-09-02 |
US20020168650A1 (en) | 2002-11-14 |
JP2008271979A (ja) | 2008-11-13 |
HUP0303888A2 (hu) | 2004-03-01 |
WO2002044418A2 (en) | 2002-06-06 |
ZA200304996B (en) | 2004-09-27 |
IL155952A0 (en) | 2003-12-23 |
CA2429722A1 (en) | 2002-06-06 |
EP1356108A2 (en) | 2003-10-29 |
US20090062133A1 (en) | 2009-03-05 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BR0115715A (pt) | Análise de expressão de ácidos nucleìcos e polipeptìdeos úteis na diagnose e tratamento de câncer da próstata | |
BR0210579A (pt) | Anticorpos, cadeias pesadas e leves, composição farmacêutica e métodos de detecção do nìvel de opgl em amostra biológia e de tratamento | |
BR0016569A (pt) | Processo de isolamento de rna de espécimes de tecido embutidos - parafina fixados - formalina | |
ATE394658T1 (de) | Spurendetektion von analyten mit hilfe artifizieller olfaktometrie | |
BRPI0413471A (pt) | métodos para detectar um ou mais complexos de proteìnas e para detectar um complexo em uma amostra biológica | |
BRPI0407397A (pt) | Evento de algodão mon 88913 e composições e métodos para sua detecção | |
BR9912007A (pt) | Composições e métodos para terapia e diagnóstico de câncer de próstata | |
TR200100267T2 (tr) | İkameli anilid bileşimleri ve yöntemler. | |
WO2001086002A3 (en) | Compositions, kits, and methods for identification, assessment, prevention, and therapy of psoriasis | |
BRPI0417903A (pt) | método de melhorar a detecção de sinal de um componente de parede celular de células | |
DE69935211D1 (de) | Diagnosesysteme auf basis von kulturen gemischter zellen | |
CY1105025T1 (el) | Αναλυση λεπτινης βασιζομενη στην ανιχνευση εκφρασης ang-2 | |
AU2002303444A1 (en) | Detection of microsatellite instability and its use in diagnosis of tumors | |
TR200201246T2 (tr) | Hidroksieikosatetraenoik asit türevlerini ihtiva eden bileşimler ve göz kuruması bozukluklarının iyileştirilmesinde kullanım yöntemleri | |
WO2005010215A3 (en) | Methods for identifying tolerance modulatory compounds and uses therefor | |
ATE350662T1 (de) | Markerproteine für prostatakrebs | |
DE60139553D1 (de) | Zusammensetzungen, testsätze und methoden zur identifizierung und modulation von typ i diabetes | |
BR0108659A (pt) | Métodos para tratamento ou prevenção ou profilaxia de câncer de mama, para detecção, diagnóstico e/ou avaliação ou prognóstico quanto ao câncer de mama, para monitoração e/ou estimativa de tratamento do câncer de mama, para identificação da presença ou ausência de células de câncer de mama metastáticas em um amostra biológica e para avaliação ou identificação de compostos, usos de uma ou mais bcmps, de uma composição, de um anticorpo, de ácido nucleico e de um agente que interaja com ou module a atividade de uma ou mais bcmps, vacina, composição, kit e anticorpo | |
BRPI0607016A2 (pt) | marcadores polipeptìdicos para o diagnóstico de cáncer de próstata | |
WO2007020522A3 (en) | Protein markers for diagnosing of colorectal cancer and use of said markers as drug targets for the treatment of said cancer type | |
WO2002090925A3 (en) | Polypeptides and nucleic acids associated with cancer | |
BR0115689A (pt) | Análise de expressão de inibidor de diferenciação de ácidos nucléicos e polipeptìdeos úteis na diagnose e tratamento de câncer da próstata | |
DE60029413D1 (de) | Enzymatische messung von mycophenolsäure | |
BR0012676A (pt) | Métodos para tratamento de tumores resistentes a terapia | |
WO2001042792A3 (en) | Diagnosis of cervical cancer using marker proteins |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: CONFORME ARTIGO 10O DA RESOLUCAO 124/06, CABE SER ARQUIVADO REFERENTE AO NAO RECOLHIMENTO DA 9A E 10A ANUIDADES. |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2144 DE 07/02/2012. |