BR0212756A - Molécula de anticorpo tendo especificidade para kdr humano, variante da molécula de anticorpo, composto, sequência de dna, vetor, célula hospedeira, processo para a produção da molécula de anticorpo, composição terapêutica ou diagnóstica, e, uso da molécula de anticorpo - Google Patents

Molécula de anticorpo tendo especificidade para kdr humano, variante da molécula de anticorpo, composto, sequência de dna, vetor, célula hospedeira, processo para a produção da molécula de anticorpo, composição terapêutica ou diagnóstica, e, uso da molécula de anticorpo

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Publication number
BR0212756A
BR0212756A BR0212756-3A BR0212756A BR0212756A BR 0212756 A BR0212756 A BR 0212756A BR 0212756 A BR0212756 A BR 0212756A BR 0212756 A BR0212756 A BR 0212756A
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BR
Brazil
Prior art keywords
antibody molecule
specificity
antibody
variant
therapeutic
Prior art date
Application number
BR0212756-3A
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English (en)
Inventor
Andrew George Popplewell
Simon Peter Tickle
Karen Zinkewich-Peotti
Robert Kendall Morrison
Original Assignee
Celltech R&D Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Celltech R&D Ltd filed Critical Celltech R&D Ltd
Publication of BR0212756A publication Critical patent/BR0212756A/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Toxicology (AREA)
  • Pain & Pain Management (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Cell Biology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Oncology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Jellies, Jams, And Syrups (AREA)
  • Bakery Products And Manufacturing Methods Therefor (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)

Abstract

"MOLéCULA DE ANTICORPO TENDO ESPECIFICIDADE PARA KDR HUMANO, VARIANTE DA MOLéCULA DE ANTICORPO, COMPOSTO, SEQuêNCIA DE DNA, VETOR, CéLULA HOSPEDEIRA, PROCESSO PARA A PRODUçãO DA MOLéCULA DE ANTICORPO, COMPOSIçãO TERAPêUTICA OU DIAGNóSTICA, E, USO DA MOLéCULA DE ANTICORPO". São apresentadas moléculas de anticorpos contendo pelo menos um CDR derivado de um anticorpo monoclonal de camundongo tendo especificidade para KDR humano. é apresentado também um anticorpo enxertado por CDR, em que pelo menos um dos CDRs é um CDR híbrido. São ainda apresentadas seq³ências de DNA que codificam as cadeias das moléculas de anticorpos, vetores, células hospedeiras transformadas, e as aplicações das moléculas de anticorpos no tratamento de doenças em que o VEGF e/ou o KDR se acham implicados.
BR0212756-3A 2001-10-10 2002-10-10 Molécula de anticorpo tendo especificidade para kdr humano, variante da molécula de anticorpo, composto, sequência de dna, vetor, célula hospedeira, processo para a produção da molécula de anticorpo, composição terapêutica ou diagnóstica, e, uso da molécula de anticorpo BR0212756A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0124317.9A GB0124317D0 (en) 2001-10-10 2001-10-10 Biological products
PCT/GB2002/004619 WO2003031475A2 (en) 2001-10-10 2002-10-10 Antibodies against kdr, their production and uses

Publications (1)

Publication Number Publication Date
BR0212756A true BR0212756A (pt) 2004-11-16

Family

ID=9923562

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0212756-3A BR0212756A (pt) 2001-10-10 2002-10-10 Molécula de anticorpo tendo especificidade para kdr humano, variante da molécula de anticorpo, composto, sequência de dna, vetor, célula hospedeira, processo para a produção da molécula de anticorpo, composição terapêutica ou diagnóstica, e, uso da molécula de anticorpo

Country Status (24)

Country Link
US (2) US7452976B2 (pt)
EP (1) EP1438340B1 (pt)
JP (2) JP4323312B2 (pt)
KR (2) KR101018908B1 (pt)
CN (1) CN1568331A (pt)
AT (1) ATE482234T1 (pt)
AU (1) AU2002334135B8 (pt)
BR (1) BR0212756A (pt)
CA (1) CA2458464A1 (pt)
CO (1) CO5580838A2 (pt)
DE (1) DE60237778D1 (pt)
DK (1) DK1438340T3 (pt)
EA (1) EA010970B1 (pt)
ES (1) ES2351208T3 (pt)
GB (1) GB0124317D0 (pt)
HU (1) HUP0401618A3 (pt)
IL (1) IL160849A0 (pt)
IS (1) IS7173A (pt)
MX (1) MXPA04003274A (pt)
NO (1) NO20040987L (pt)
NZ (1) NZ532758A (pt)
PL (1) PL208848B1 (pt)
WO (1) WO2003031475A2 (pt)
ZA (1) ZA200401910B (pt)

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Also Published As

Publication number Publication date
PL370344A1 (en) 2005-05-16
ES2351208T3 (es) 2011-02-01
WO2003031475A3 (en) 2004-03-25
IL160849A0 (en) 2004-08-31
NO20040987L (no) 2004-05-10
US20050181448A1 (en) 2005-08-18
US7452976B2 (en) 2008-11-18
DK1438340T3 (da) 2010-11-22
ATE482234T1 (de) 2010-10-15
KR20040097983A (ko) 2004-11-18
GB0124317D0 (en) 2001-11-28
US7842787B2 (en) 2010-11-30
EP1438340A2 (en) 2004-07-21
ZA200401910B (en) 2005-03-09
MXPA04003274A (es) 2004-07-08
CA2458464A1 (en) 2003-04-17
KR20070116110A (ko) 2007-12-06
KR101018908B1 (ko) 2011-03-02
US20090269840A1 (en) 2009-10-29
EA010970B1 (ru) 2008-12-30
NZ532758A (en) 2008-04-30
WO2003031475A8 (en) 2004-10-14
AU2002334135B2 (en) 2009-01-08
JP2009108086A (ja) 2009-05-21
WO2003031475A2 (en) 2003-04-17
DE60237778D1 (de) 2010-11-04
IS7173A (is) 2004-03-05
EA200400519A1 (ru) 2004-12-30
PL208848B1 (pl) 2011-06-30
HUP0401618A2 (hu) 2004-11-29
CO5580838A2 (es) 2005-11-30
EP1438340B1 (en) 2010-09-22
HUP0401618A3 (en) 2012-03-28
JP4323312B2 (ja) 2009-09-02
AU2002334135B8 (en) 2009-01-29
JP2005516590A (ja) 2005-06-09
CN1568331A (zh) 2005-01-19

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