|
US8038994B2
(en)
|
1996-05-15 |
2011-10-18 |
Quest Pharmatech Inc. |
Combination therapy for treating disease
|
|
US6949245B1
(en)
|
1999-06-25 |
2005-09-27 |
Genentech, Inc. |
Humanized anti-ErbB2 antibodies and treatment with anti-ErbB2 antibodies
|
|
BR0012196A
(pt)
*
|
1999-06-25 |
2002-03-19 |
Genentech Inc |
Método de tratamento de um tumor em mamìferos através do uso de conjugados de maitansinóide e anticorpo receptor anti-erbb e artigo industrializado
|
|
CN100340575C
(zh)
*
|
1999-06-25 |
2007-10-03 |
杰南技术公司 |
人源化抗ErbB2抗体及其在制备药物中的应用
|
|
US6825333B1
(en)
|
1999-08-20 |
2004-11-30 |
Chiron Corporation |
EGFH2 genes and gene products
|
|
KR20110008112A
(ko)
|
1999-08-27 |
2011-01-25 |
제넨테크, 인크. |
항-ErbB2 항체 투여 치료 방법
|
|
AU775373B2
(en)
|
1999-10-01 |
2004-07-29 |
Immunogen, Inc. |
Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
|
|
CA2407556C
(en)
|
2000-05-19 |
2011-06-21 |
Genentech, Inc. |
Gene detection assay for improving the likelihood of an effective response to an erbb antagonist cancer therapy
|
|
EP1228766A1
(en)
*
|
2001-01-31 |
2002-08-07 |
Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. |
PYK2 phosphorylation by HER3 induces tumor invasion
|
|
AT500649A1
(de)
*
|
2001-10-26 |
2006-02-15 |
Altarex Medical Corp |
Kombinationstherapie zur krankheitsbehandlung
|
|
WO2003087338A2
(en)
*
|
2002-04-11 |
2003-10-23 |
Amgen, Inc. |
Her-2 receptor tyrosine kinase molecules and uses thereof
|
|
ITTO20020340A1
(it)
*
|
2002-04-19 |
2003-10-20 |
Biother Di Contardi Gabriella |
Localizzazione del recettore her2 mediante anticorpo umanizzato biotinilato.
|
|
AU2003237367A1
(en)
|
2002-06-03 |
2003-12-19 |
Chiron Corporation |
Use of nrg4, or inhibitors thereof, in the treatment of colon and pancreatic cancer
|
|
AT413486B
(de)
*
|
2002-07-03 |
2006-03-15 |
Igeneon Krebs Immuntherapie |
Verwendung eines antikörpers gerichtet gegen lewis-antigene
|
|
WO2004008099A2
(en)
*
|
2002-07-15 |
2004-01-22 |
Genentech, Inc. |
METHODS FOR IDENTIFYING TUMORS THAT ARE RESPONSIVE TO TREATMENT WITH ANTI-ErbB2 ANTIBODIES
|
|
NO340576B1
(no)
*
|
2002-07-11 |
2017-05-15 |
Hoffmann La Roche |
Rekombinant, humanisert antistoff 2C4 (rhuMab 2C4) for anvendelse sammen med et andre, forskjellig vekstinhiberende anti-ErbB2-antistoff i en fremgangsmåte for behandling av kreft i en pasient og anvendelse derav for fremstilling av et medikament
|
|
USRE47770E1
(en)
|
2002-07-18 |
2019-12-17 |
Merus N.V. |
Recombinant production of mixtures of antibodies
|
|
UA81634C2
(ru)
|
2002-07-18 |
2008-01-25 |
Хеликс Биофарма Корп. |
Фармацевтическая композиция уреазы для ингибирования роста раковых клеток и ее применение
|
|
DK2314629T4
(da)
|
2002-07-18 |
2023-02-06 |
Merus Nv |
Rekombinant produktion af blandinger af antistoffer
|
|
US7264800B2
(en)
|
2002-07-18 |
2007-09-04 |
Helix Biopharma Corporation |
Method and composition for inhibiting cancer cell growth
|
|
JP5138867B2
(ja)
|
2002-08-01 |
2013-02-06 |
イミューノメディクス、インコーポレイテッド |
α−フェトタンパク質Immu31抗体および融合タンパク質ならびにその使用方法
|
|
US20040033228A1
(en)
|
2002-08-16 |
2004-02-19 |
Hans-Juergen Krause |
Formulation of human antibodies for treating TNF-alpha associated disorders
|
|
CN101972478B
(zh)
*
|
2002-10-08 |
2012-10-31 |
免疫医疗公司 |
抗体治疗
|
|
CA2508831C
(en)
*
|
2002-12-13 |
2012-05-01 |
Immunomedics, Inc. |
Immunoconjugates with an intracellularly-cleavable linkage
|
|
JP2007517767A
(ja)
*
|
2003-03-11 |
2007-07-05 |
ダナ ファーバー キャンサー インスティテュート |
ウイルスの病原性の阻害方法
|
|
JP2007525458A
(ja)
*
|
2003-04-23 |
2007-09-06 |
メダレックス インコーポレイテッド |
インターフェロンα受容体−1(IFNAR−1)に対するヒト化抗体
|
|
US8088387B2
(en)
|
2003-10-10 |
2012-01-03 |
Immunogen Inc. |
Method of targeting specific cell populations using cell-binding agent maytansinoid conjugates linked via a non-cleavable linker, said conjugates, and methods of making said conjugates
|
|
AT500651B9
(de)
*
|
2003-05-27 |
2010-04-15 |
Altropus Gmbh |
Aktiv immunisierender antikörper
|
|
WO2004106375A1
(en)
|
2003-05-30 |
2004-12-09 |
Merus Biopharmaceuticals B.V. I.O. |
Fab library for the preparation of anti vegf and anti rabies virus fabs
|
|
US20100069614A1
(en)
|
2008-06-27 |
2010-03-18 |
Merus B.V. |
Antibody producing non-human mammals
|
|
DK3095793T3
(da)
|
2003-07-28 |
2020-05-25 |
Genentech Inc |
Reducering af udvaskning af protein A under en protein A-affinitetskromatografi
|
|
US20070104714A1
(en)
*
|
2003-08-29 |
2007-05-10 |
Cedars-Sinai Medical Center |
Composition and method for the treatment of cancer and other physiologic conditins based on modulation of the ppar-gamma pathway and her-kinase axis
|
|
CN101048425B
(zh)
*
|
2003-09-18 |
2012-12-26 |
雷文生物技术公司 |
Kid3及与其结合的kid3抗体
|
|
EP1708750A1
(en)
*
|
2003-11-28 |
2006-10-11 |
Mitra Medical AB |
Targeting of erb antigens
|
|
RU2402568C2
(ru)
*
|
2004-02-06 |
2010-10-27 |
МорфоСис АГ |
Человеческие анти-cd38-антитела и их применение
|
|
RU2273475C2
(ru)
*
|
2004-04-06 |
2006-04-10 |
Государственное учреждение системы высшего и послевузовского профессионального образования "Сибирский государственный медицинский университет" (ГУ СВ ПО СибГМУ) |
Способ лечения диссеминированного колоректального рака
|
|
NZ579482A
(en)
|
2004-06-01 |
2011-02-25 |
Genentech Inc |
Antibody drug conjugates and methods
|
|
GT200500155A
(es)
*
|
2004-06-16 |
2006-05-15 |
|
Terapia del càncer resistente al platino
|
|
DK1771482T3
(da)
|
2004-07-22 |
2014-10-20 |
Genentech Inc |
HER2-antistofsammensætning
|
|
DK1791565T3
(en)
|
2004-09-23 |
2016-08-01 |
Genentech Inc |
Cysteingensplejsede antibodies and conjugates
|
|
US20100111856A1
(en)
|
2004-09-23 |
2010-05-06 |
Herman Gill |
Zirconium-radiolabeled, cysteine engineered antibody conjugates
|
|
JO3000B1
(ar)
|
2004-10-20 |
2016-09-05 |
Genentech Inc |
مركبات أجسام مضادة .
|
|
WO2006063042A2
(en)
*
|
2004-12-07 |
2006-06-15 |
Genentech, Inc. |
Selecting patients for therapy with a her inhibitor
|
|
CN102580084B
(zh)
*
|
2005-01-21 |
2016-11-23 |
健泰科生物技术公司 |
Her抗体的固定剂量给药
|
|
EP1850874B1
(en)
|
2005-02-23 |
2013-10-16 |
Genentech, Inc. |
Extending time to disease progression or survival in ovarian cancer patients using pertuzumab
|
|
AR053272A1
(es)
*
|
2005-05-11 |
2007-04-25 |
Hoffmann La Roche |
Determinacion de responsivos a la quimioterapia
|
|
WO2006132788A2
(en)
|
2005-06-06 |
2006-12-14 |
Genentech, Inc. |
Transgenic models for different genes and their use for gene characterization
|
|
US7700299B2
(en)
|
2005-08-12 |
2010-04-20 |
Hoffmann-La Roche Inc. |
Method for predicting the response to a treatment
|
|
EP1922410A2
(en)
|
2005-08-15 |
2008-05-21 |
Genentech, Inc. |
Gene disruptions, compositions and methods relating thereto
|
|
KR101164820B1
(ko)
|
2005-09-22 |
2012-07-12 |
삼성전자주식회사 |
디스플레이장치
|
|
US8080534B2
(en)
|
2005-10-14 |
2011-12-20 |
Phigenix, Inc |
Targeting PAX2 for the treatment of breast cancer
|
|
EP1962584A2
(en)
|
2005-11-21 |
2008-09-03 |
Genentech, Inc. |
Novel gene disruptions, compositions and methods relating thereto
|
|
AR056857A1
(es)
|
2005-12-30 |
2007-10-24 |
U3 Pharma Ag |
Anticuerpos dirigidos hacia her-3 (receptor del factor de crecimiento epidérmico humano-3) y sus usos
|
|
JO2660B1
(en)
|
2006-01-20 |
2012-06-17 |
نوفارتيس ايه جي |
Pi-3 inhibitors and methods of use
|
|
EP2050335A1
(en)
|
2006-02-17 |
2009-04-22 |
Genentech, Inc. |
Gene disruptions, compositions and methods relating thereto
|
|
TW200812615A
(en)
|
2006-03-22 |
2008-03-16 |
Hoffmann La Roche |
Tumor therapy with an antibody for vascular endothelial growth factor and an antibody for human epithelial growth factor receptor type 2
|
|
AR060358A1
(es)
|
2006-04-06 |
2008-06-11 |
Novartis Vaccines & Diagnostic |
Quinazolinas para la inhibicion de pdk 1
|
|
CA2649387A1
(en)
|
2006-04-19 |
2008-03-27 |
Genentech, Inc. |
Novel gene disruptions, compositions and methods relating thereto
|
|
WO2007145862A2
(en)
*
|
2006-06-05 |
2007-12-21 |
Genentech, Inc. |
Extending survival of cancer patients with elevated levels of egf or tgf-alpha
|
|
EP2032606B1
(en)
|
2006-05-30 |
2013-11-27 |
Genentech, Inc. |
Antibodies and immunoconjugates and uses therefor
|
|
CL2007002404A1
(es)
|
2006-08-21 |
2008-04-18 |
Hoffmann La Roche |
Uso de un anticuerpo anti-vegf (factor de crecimiento endotelial vascular) para el tratamiento de un paciente que padece una recaida de cancer her2 positivo durante o despues del tratamiento con un anticuerpo anti-her2.
|
|
WO2008031531A1
(en)
*
|
2006-09-15 |
2008-03-20 |
F. Hoffmann-La Roche Ag |
Tumor therapy with a combination of anti-her2 antibodies
|
|
CN103396486A
(zh)
|
2006-10-12 |
2013-11-20 |
中外制药株式会社 |
使用抗ereg抗体的癌症的诊断和治疗
|
|
BRPI0717638A2
(pt)
|
2006-10-27 |
2013-11-12 |
Genentech Inc |
Anticorpors e imunoconjugados e usos para os mesmos
|
|
SI2132573T1
(sl)
|
2007-03-02 |
2014-07-31 |
Genentech, Inc. |
Napovedovanje odziva na inhibitor dimerizacije HER na osnovi nizke ekspresije HER3
|
|
PL2171090T3
(pl)
|
2007-06-08 |
2013-09-30 |
Genentech Inc |
Markery ekspresji genów odporności guza na leczenie hamujące HER2
|
|
US9551033B2
(en)
|
2007-06-08 |
2017-01-24 |
Genentech, Inc. |
Gene expression markers of tumor resistance to HER2 inhibitor treatment
|
|
US20100254996A1
(en)
*
|
2007-06-18 |
2010-10-07 |
Medimmune, Llc |
Synergistic treatment of cells that express epha2 and erbb2
|
|
PE20090943A1
(es)
|
2007-07-16 |
2009-08-05 |
Genentech Inc |
Anticuerpos anti-cd79b e inmunoconjugados
|
|
EP2176295B1
(en)
|
2007-07-16 |
2014-11-19 |
Genentech, Inc. |
Humanized anti-cd79b antibodies and immunoconjugates and methods of use
|
|
ES2533266T5
(es)
|
2007-10-30 |
2018-04-18 |
Genentech, Inc. |
Purificación de anticuerpos mediante cromatografía de intercambio catiónico
|
|
EP2650311A3
(en)
*
|
2007-11-27 |
2014-06-04 |
Ablynx N.V. |
Amino acid sequences directed against heterodimeric cytokines and/or their receptors and polypeptides comprising the same
|
|
EP2240475B1
(en)
|
2007-12-20 |
2013-09-25 |
Novartis AG |
Thiazole derivatives used as pi 3 kinase inhibitors
|
|
KR101658247B1
(ko)
|
2008-01-03 |
2016-09-22 |
더 스크립스 리서치 인스티튜트 |
모듈 인식 도메인을 통한 항체 표적화
|
|
US8557243B2
(en)
|
2008-01-03 |
2013-10-15 |
The Scripps Research Institute |
EFGR antibodies comprising modular recognition domains
|
|
US8574577B2
(en)
|
2008-01-03 |
2013-11-05 |
The Scripps Research Institute |
VEGF antibodies comprising modular recognition domains
|
|
US8454960B2
(en)
|
2008-01-03 |
2013-06-04 |
The Scripps Research Institute |
Multispecific antibody targeting and multivalency through modular recognition domains
|
|
US8557242B2
(en)
|
2008-01-03 |
2013-10-15 |
The Scripps Research Institute |
ERBB2 antibodies comprising modular recognition domains
|
|
TWI472339B
(zh)
|
2008-01-30 |
2015-02-11 |
Genentech Inc |
包含結合至her2結構域ii之抗體及其酸性變異體的組合物
|
|
KR101607346B1
(ko)
|
2008-01-31 |
2016-03-29 |
제넨테크, 인크. |
항-cd79b 항체 및 면역접합체 및 사용 방법
|
|
EP2260111B2
(en)
*
|
2008-03-14 |
2022-03-23 |
Genentech, Inc. |
Genetic variations associated with drug resistance
|
|
DK2644194T3
(en)
*
|
2008-03-18 |
2017-07-03 |
Genentech Inc |
Combinations of an anti-HER2 antibody-drug conjugate and docetaxel
|
|
RU2553225C2
(ru)
|
2008-05-23 |
2015-06-10 |
Сива Корпорейшн |
Способ облегчения регенерации
|
|
BRPI0812682A2
(pt)
|
2008-06-16 |
2010-06-22 |
Genentech Inc |
tratamento de cáncer de mama metastático
|
|
CN103599541A
(zh)
|
2008-09-10 |
2014-02-26 |
弗·哈夫曼-拉罗切有限公司 |
用于防止蛋白质氧化降解的组合物和方法
|
|
ES3000111T3
(en)
|
2009-02-13 |
2025-02-27 |
Immunomedics Inc |
Intermediates for preparing conjugates with an intracellularly-cleavable linkage
|
|
MY152068A
(en)
|
2009-03-20 |
2014-08-15 |
Genentech Inc |
Bispecific anti-her antibodies
|
|
RU2587621C2
(ru)
|
2009-04-01 |
2016-06-20 |
Дженентек, Инк. |
АНТИТЕЛА К FcRH5, ИХ ИММУНОКОНЪЮГАТЫ И СПОСОБЫ ИХ ПРИМЕНЕНИЯ
|
|
EP2417164A1
(en)
|
2009-04-07 |
2012-02-15 |
Roche Glycart AG |
Bispecific anti-erbb-2/anti-c-met antibodies
|
|
CN102421448A
(zh)
|
2009-05-29 |
2012-04-18 |
霍夫曼-拉罗奇有限公司 |
Her2信号传导调控剂在表达her2的胃癌患者中
|
|
EP2436397B1
(en)
|
2009-05-29 |
2017-05-10 |
Chugai Seiyaku Kabushiki Kaisha |
Pharmaceutical composition containing antagonist of egf family ligand as component
|
|
US8293753B2
(en)
|
2009-07-02 |
2012-10-23 |
Novartis Ag |
Substituted 2-carboxamide cycloamino ureas
|
|
US9345661B2
(en)
|
2009-07-31 |
2016-05-24 |
Genentech, Inc. |
Subcutaneous anti-HER2 antibody formulations and uses thereof
|
|
HRP20200768T4
(hr)
|
2009-08-11 |
2025-03-28 |
F. Hoffmann - La Roche Ag |
Proizvodnja proteina u mediju za uzgoj stanica bez glutamina
|
|
NZ598131A
(en)
*
|
2009-08-15 |
2014-08-29 |
Genentech Inc |
Anti-angiogenesis therapy for the treatment of previously treated breast cancer
|
|
SI2473617T1
(sl)
|
2009-09-01 |
2020-07-31 |
F. Hoffmann-La Roche Ag |
Izboljšano prečiščevanje beljakovin z modificirano elucijo beljakovine A
|
|
AR078161A1
(es)
|
2009-09-11 |
2011-10-19 |
Hoffmann La Roche |
Formulaciones farmaceuticas muy concentradas de un anticuerpo anti cd20. uso de la formulacion. metodo de tratamiento.
|
|
JP5898082B2
(ja)
|
2009-10-07 |
2016-04-06 |
マクロジェニクス,インコーポレーテッド |
フコシル化程度の変更により改良されたエフェクター機能を示すFc領域含有ポリペプチドおよびその使用法
|
|
CA2777825A1
(en)
*
|
2009-10-28 |
2011-05-19 |
Abbott Biotherapeutics Corp. |
Anti-egfr antibodies and their uses
|
|
EP2496601B1
(en)
|
2009-11-05 |
2017-06-07 |
F. Hoffmann-La Roche AG |
Methods and composition for secretion of heterologous polypeptides
|
|
EP2896632B1
(en)
|
2009-11-13 |
2017-10-25 |
Daiichi Sankyo Europe GmbH |
Material and methods for treating or preventing HER-3 associated diseases
|
|
CN102770456B
(zh)
|
2009-12-04 |
2018-04-06 |
弗·哈夫曼-拉罗切有限公司 |
多特异性抗体、抗体类似物、组合物和方法
|
|
US9115200B2
(en)
*
|
2010-02-04 |
2015-08-25 |
Toray Industries, Inc. |
Pharmaceutical composition for treating cancer using a monoclonal antibody having immunological reactivity with CAPRIN-1
|
|
US9556249B2
(en)
*
|
2010-02-18 |
2017-01-31 |
Genentech, Inc. |
Neuregulin antagonists and use thereof in treating cancer
|
|
US8609095B2
(en)
|
2010-03-04 |
2013-12-17 |
Symphogen A/S |
Anti-HER2 antibodies and compositions
|
|
EP2550018B1
(en)
|
2010-03-22 |
2019-02-27 |
F.Hoffmann-La Roche Ag |
Compositions and methods useful for stabilizing protein-containing formulations
|
|
BR112012027828A2
(pt)
|
2010-05-03 |
2016-08-09 |
Genentech Inc |
composição de matéria, artigo de fabricação e método de redução da viscosidade de uma formulação contendo proteína e de preparação de uma formulação aquosa contendo proteína
|
|
WO2011146568A1
(en)
|
2010-05-19 |
2011-11-24 |
Genentech, Inc. |
Predicting response to a her inhibitor
|
|
EP2576621B1
(en)
|
2010-05-27 |
2019-04-10 |
Genmab A/S |
Monoclonal antibodies against her2
|
|
CA2800769C
(en)
|
2010-05-27 |
2021-11-02 |
Genmab A/S |
Monoclonal antibodies against her2 epitope
|
|
CA2800728C
(en)
|
2010-05-28 |
2020-10-27 |
Genentech, Inc. |
Decreasing lactate level and increasing polypeptide production by downregulating the expression of lactate dehydrogenase and pyruvate dehydrogenase kinase
|
|
NZ701208A
(en)
|
2010-06-03 |
2016-05-27 |
Genentech Inc |
Immuno-pet imaging of antibodies and immunoconjugates and uses thereof
|
|
CA2799540A1
(en)
|
2010-06-08 |
2011-12-15 |
Genentech, Inc. |
Cysteine engineered antibodies and conjugates
|
|
SG186783A1
(en)
|
2010-06-24 |
2013-02-28 |
Genentech Inc |
Compositions and methods containing alkylgycosides for stabilizing protein- containing formulations
|
|
WO2012009705A1
(en)
|
2010-07-15 |
2012-01-19 |
Zyngenia, Inc. |
Ang-2 binding complexes and uses thereof
|
|
AR082418A1
(es)
|
2010-08-02 |
2012-12-05 |
Novartis Ag |
Formas cristalinas de 1-(4-metil-5-[2-(2,2,2-trifluoro-1,1-dimetil-etil)-piridin-4-il]-tiazol-2-il)-amida de 2-amida del acido (s)-pirrolidin-1,2-dicarboxilico
|
|
TW201302793A
(zh)
|
2010-09-03 |
2013-01-16 |
Glaxo Group Ltd |
新穎之抗原結合蛋白
|
|
US8721571B2
(en)
|
2010-11-22 |
2014-05-13 |
Siwa Corporation |
Selective removal of cells having accumulated agents
|
|
WO2012069466A1
(en)
|
2010-11-24 |
2012-05-31 |
Novartis Ag |
Multispecific molecules
|
|
KR101574864B1
(ko)
|
2010-12-21 |
2015-12-11 |
에프. 호프만-라 로슈 아게 |
이소폼이 농축된 항체 제제 및 그의 제조 방법
|
|
SG191153A1
(en)
|
2010-12-23 |
2013-07-31 |
Hoffmann La Roche |
Polypeptide-polynucleotide-complex and its use in targeted effector moiety delivery
|
|
EP2655414B1
(en)
|
2010-12-23 |
2018-08-29 |
Roche Diagniostics GmbH |
Bispecific binding agent
|
|
MX343706B
(es)
|
2011-01-31 |
2016-11-18 |
Novartis Ag |
Derivados heterocíclicos novedosos.
|
|
CN103649326B
(zh)
*
|
2011-03-08 |
2016-08-17 |
宾夕法尼亚大学理事会 |
用于治疗和诊断用途的抗体样蛋白
|
|
AU2012245116A1
(en)
|
2011-04-20 |
2013-11-07 |
Genmab A/S |
Bispecific antibodies against HER2 and CD3
|
|
EP2714738B1
(en)
|
2011-05-24 |
2018-10-10 |
Zyngenia, Inc. |
Multivalent and monovalent multispecific complexes and their uses
|
|
MX2014001766A
(es)
|
2011-08-17 |
2014-05-01 |
Genentech Inc |
Anticuerpos de neuregulina y sus usos.
|
|
IL301603A
(en)
|
2011-10-14 |
2023-05-01 |
Genentech Inc |
Pertuzumab, trastuzumab, docetaxel and carboplatin for use in the preoperative treatment of a patient
|
|
US9327023B2
(en)
|
2011-10-25 |
2016-05-03 |
The Regents Of The University Of Michigan |
HER2 targeting agent treatment in non-HER2-amplified cancers having HER2 expressing cancer stem cells
|
|
PT2771342T
(pt)
|
2011-10-28 |
2016-08-17 |
Novartis Ag |
Derivados de purina e o seu uso no tratamento de doença
|
|
DK2797957T3
(da)
|
2011-11-23 |
2019-09-23 |
Medimmune Llc |
Bindingsmolekyler specifikke for her3 og anvendelser deraf
|
|
BR112014012979A2
(pt)
|
2011-11-30 |
2020-10-20 |
Genentech, Inc. |
mutações erbb3 em câncer
|
|
US9376715B2
(en)
|
2011-12-09 |
2016-06-28 |
Roche Molecular Systems, Inc |
Methods for detecting mutations in the catalytic subunit of the phosphoinositol-3 kinase (PIK3CA) gene
|
|
RU2648999C2
(ru)
|
2011-12-22 |
2018-03-29 |
Дженентек, Инк. |
Способы повышения эффективности этапов очистки белка, находящихся ниже по потоку, с использованием мембранной ионообменной хроматографии
|
|
TWI593705B
(zh)
|
2011-12-28 |
2017-08-01 |
Chugai Pharmaceutical Co Ltd |
Humanized anti-epiregulin antibody and cancer therapeutic agent containing the antibody as an active ingredient
|
|
WO2013113796A1
(en)
|
2012-01-31 |
2013-08-08 |
Smithkline Beecham (Cork) Limited |
Method of treating cancer
|
|
EP2638916A1
(en)
|
2012-03-16 |
2013-09-18 |
Covagen AG |
Novel binding molecules with antitumoral activity
|
|
US20130259867A1
(en)
|
2012-03-27 |
2013-10-03 |
Genentech, Inc. |
Diagnosis and treatments relating to her3 inhibitors
|
|
US9248181B2
(en)
|
2012-04-20 |
2016-02-02 |
Merus B.V. |
Methods and means for the production of Ig-like molecules
|
|
KR101505157B1
(ko)
*
|
2012-05-08 |
2015-03-24 |
주식회사 종근당 |
항―ErbB2 항체 변이체
|
|
WO2013173283A1
(en)
|
2012-05-16 |
2013-11-21 |
Novartis Ag |
Dosage regimen for a pi-3 kinase inhibitor
|
|
KR102291355B1
(ko)
|
2012-11-30 |
2021-08-19 |
에프. 호프만-라 로슈 아게 |
Pd-l1 억제제 공동치료를 필요로 하는 환자의 식별방법
|
|
US20150329524A1
(en)
|
2013-01-10 |
2015-11-19 |
Glaxosmithkline Intellectual Property (No.2) Limited |
Fatty acid synthase inhibitors
|
|
AR094403A1
(es)
|
2013-01-11 |
2015-07-29 |
Hoffmann La Roche |
Terapia de combinación de anticuerpos anti-her3
|
|
US10150800B2
(en)
|
2013-03-15 |
2018-12-11 |
Zyngenia, Inc. |
EGFR-binding modular recognition domains
|
|
CN104628846B
(zh)
|
2013-11-06 |
2019-12-06 |
三生国健药业(上海)股份有限公司 |
重组蛋白质的纯化方法
|
|
KR101936697B1
(ko)
*
|
2013-11-19 |
2019-01-10 |
레메젠 리미티드 |
항-her2 항체 및 이의 접합체
|
|
AU2014357292B2
(en)
*
|
2013-11-27 |
2020-06-25 |
Zymeworks Bc Inc. |
Bispecific antigen-binding constructs targeting HER2
|
|
CN105979947A
(zh)
|
2013-12-06 |
2016-09-28 |
诺华股份有限公司 |
α-同工型选择性磷脂酰肌醇3-激酶抑制剂的剂量方案
|
|
IL310627B2
(en)
|
2014-01-31 |
2026-04-01 |
Daiichi Sankyo Co Ltd |
Anti-HER2 antibody-drug conjugates, compositions containing them and uses thereof
|
|
US20160361309A1
(en)
|
2014-02-26 |
2016-12-15 |
Glaxosmithkline Intellectual Property (No.2) Limited |
Methods of treating cancer patients responding to ezh2 inhibitor gsk126
|
|
AU2015229035B2
(en)
|
2014-03-14 |
2021-08-05 |
Genentech, Inc. |
Methods and compositions for secretion of heterologous polypeptides
|
|
SG11201608192SA
(en)
|
2014-04-11 |
2016-10-28 |
Medimmune Llc |
Bispecific her2 antibodies
|
|
SG11201701128YA
(en)
|
2014-09-12 |
2017-03-30 |
Genentech Inc |
Cysteine engineered antibodies and conjugates
|
|
EP3194439B1
(en)
|
2014-09-19 |
2022-01-19 |
Siwa Corporation |
Anti-age antibodies for treating inflammation and auto-immune disorders
|
|
US10385380B2
(en)
|
2014-10-02 |
2019-08-20 |
The Regents Of The University Of California |
Personalized protease assay to measure protease activity in neoplasms
|
|
WO2016082044A1
(en)
|
2014-11-27 |
2016-06-02 |
Zymeworks Inc. |
Methods of using bispecific antigen-binding constructs targeting her2
|
|
US9993535B2
(en)
|
2014-12-18 |
2018-06-12 |
Siwa Corporation |
Method and composition for treating sarcopenia
|
|
US10358502B2
(en)
|
2014-12-18 |
2019-07-23 |
Siwa Corporation |
Product and method for treating sarcopenia
|
|
KR101515535B1
(ko)
|
2015-01-28 |
2015-05-06 |
주식회사 종근당 |
항―ErbB2 항체 변이체
|
|
MA41414A
(fr)
|
2015-01-28 |
2017-12-05 |
Centre Nat Rech Scient |
Protéines de liaison agonistes d' icos
|
|
ES3057390T3
(en)
|
2015-05-13 |
2026-03-02 |
Zymeworks Bc Inc |
Antigen-binding constructs targeting her2
|
|
US20180230431A1
(en)
|
2015-08-07 |
2018-08-16 |
Glaxosmithkline Intellectual Property Development Limited |
Combination Therapy
|
|
CN108431044A
(zh)
*
|
2015-10-13 |
2018-08-21 |
Siwa有限公司 |
抗age抗体及其使用方法
|
|
RU2018119085A
(ru)
|
2015-11-02 |
2019-12-04 |
Новартис Аг |
Схема введения ингибитора фосфатидилинозитол-3-киназы
|
|
CN106729743B
(zh)
|
2015-11-23 |
2021-09-21 |
四川科伦博泰生物医药股份有限公司 |
抗ErbB2抗体-药物偶联物及其组合物、制备方法和应用
|
|
JP2019505476A
(ja)
|
2015-12-01 |
2019-02-28 |
グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドGlaxosmithkline Intellectual Property Development Limited |
組合せ処置およびその方法
|
|
IL260021B
(en)
|
2015-12-14 |
2022-09-01 |
Macrogenics Inc |
Bispecific molecules that are immunoreactive for pd1 and ctla4 and methods for using them
|
|
CN105646704B
(zh)
*
|
2015-12-28 |
2019-11-15 |
广西医科大学 |
抗p185erbB2人鼠嵌合抗体ChAb26、乳腺特异性表达载体、转基因FVB小鼠及其制备方法
|
|
HUE058854T2
(hu)
|
2016-02-19 |
2022-09-28 |
Siwa Corp |
Módszer és készítmény a rák kezelésére, az áttétes rákos sejtek elpusztítására és a rák áttétképzõdésének megelõzésére a fejlett glikációs végtermékek (AGE) elleni antitest alkalmazásával
|
|
AU2017235450A1
(en)
*
|
2016-03-15 |
2018-08-16 |
Merrimack Pharmaceuticals, Inc. |
Methods for treating ER+, HER2-, HRG+ breast cancer using combination therapies comprising an anti-ErbB3 antibody
|
|
KR20180133452A
(ko)
|
2016-04-15 |
2018-12-14 |
시와 코퍼레이션 |
신경퇴행성 질환을 치료하기 위한 항-노화 항체
|
|
US20190151346A1
(en)
|
2016-05-10 |
2019-05-23 |
INSERM (Institute National de la Santé et de la Recherche Médicale) |
Combinations therapies for the treatment of cancer
|
|
CN109476744B
(zh)
*
|
2016-05-12 |
2023-04-11 |
新加坡科技研究局 |
抗erbb-2抗体及其用途
|
|
JP2019518763A
(ja)
|
2016-06-23 |
2019-07-04 |
シワ コーポレーション |
様々な疾患及び障害の治療において使用するためのワクチン
|
|
WO2018060833A1
(en)
|
2016-09-27 |
2018-04-05 |
Novartis Ag |
Dosage regimen for alpha-isoform selective phosphatidylinositol 3-kinase inhibitor alpelisib
|
|
KR20190066026A
(ko)
|
2016-10-07 |
2019-06-12 |
다이이찌 산쿄 가부시키가이샤 |
항 her2 항체-약물 콘주게이트 투여에 의한 내성암의 치료
|
|
US11273155B2
(en)
|
2016-12-12 |
2022-03-15 |
Daiichi Sankyo Company, Limited |
Combination of antibody-drug conjugate and immune checkpoint inhibitor
|
|
EP3565845A4
(en)
*
|
2017-01-06 |
2020-10-07 |
Biosion, Inc. |
ERBB2 ANTIBODIES AND THEIR USES
|
|
US10858449B1
(en)
|
2017-01-06 |
2020-12-08 |
Siwa Corporation |
Methods and compositions for treating osteoarthritis
|
|
US10925937B1
(en)
|
2017-01-06 |
2021-02-23 |
Siwa Corporation |
Vaccines for use in treating juvenile disorders associated with inflammation
|
|
US10961321B1
(en)
|
2017-01-06 |
2021-03-30 |
Siwa Corporation |
Methods and compositions for treating pain associated with inflammation
|
|
US10995151B1
(en)
|
2017-01-06 |
2021-05-04 |
Siwa Corporation |
Methods and compositions for treating disease-related cachexia
|
|
AU2018224094B2
(en)
|
2017-02-24 |
2025-04-17 |
Macrogenics, Inc. |
Bispecific binding molecules that are capable of binding CD137 and tumor antigens, and uses thereof
|
|
TW201834649A
(zh)
|
2017-03-02 |
2018-10-01 |
新加坡商亞獅康私人有限公司 |
癌症療法
|
|
PT3589661T
(pt)
|
2017-03-02 |
2024-01-29 |
Genentech Inc |
Tratamento com adjuvante de cancro da mama positivo para her2
|
|
MA49279A
(fr)
|
2017-03-22 |
2020-02-05 |
Hoffmann La Roche |
Compositions d'anticorps optimisées pour le traitement de troubles oculaires
|
|
CA3059803A1
(en)
|
2017-04-13 |
2018-10-18 |
Siwa Corporation |
Humanized monoclonal advanced glycation end-product antibody
|
|
WO2018222135A1
(en)
|
2017-06-02 |
2018-12-06 |
Aslan Pharmaceuticals Pte Ltd |
Cancer therapy
|
|
CN107417791B
(zh)
*
|
2017-08-17 |
2020-09-22 |
合肥瀚科迈博生物技术有限公司 |
抗人ErbB2双特异性抗体、其制备方法及用途
|
|
AU2018320470B2
(en)
|
2017-08-23 |
2025-04-24 |
Daiichi Sankyo Company, Limited |
Antibody-drug conjugate preparation and lyophilization for same
|
|
CA3074208C
(en)
|
2017-08-31 |
2023-10-03 |
Daiichi Sankyo Company, Limited |
Novel method for producing antibody-drug conjugate
|
|
IL324591A
(en)
|
2017-08-31 |
2026-01-01 |
Daiichi Sankyo Co Ltd |
Improved antibody-drug conjugate production methods
|
|
CN107789631B
(zh)
*
|
2017-11-03 |
2021-03-16 |
合肥瀚科迈博生物技术有限公司 |
抗人ErbB2双表位抗体-药物偶联物及其应用
|
|
KR20200098590A
(ko)
|
2017-12-12 |
2020-08-20 |
마크로제닉스, 인크. |
이중특이적 cd16-결합 분자 및 질환 치료에서의 그것의 용도
|
|
US11518801B1
(en)
|
2017-12-22 |
2022-12-06 |
Siwa Corporation |
Methods and compositions for treating diabetes and diabetic complications
|
|
JP7337079B2
(ja)
|
2018-02-15 |
2023-09-01 |
マクロジェニクス,インコーポレーテッド |
変異型cd3結合ドメイン、及び疾患の治療のための併用療法におけるその使用
|
|
EP3560945A1
(en)
|
2018-04-27 |
2019-10-30 |
F. Hoffmann-La Roche AG |
Methods for purification of polypeptides using polysorbates
|
|
IL278988B2
(en)
|
2018-05-28 |
2024-10-01 |
Daiichi Sankyo Co Ltd |
Anti-her2 antibody-drug conjugates for use in the treatment of her-2 mutated cancer
|
|
IL318587A
(en)
|
2018-07-23 |
2025-03-01 |
Trevi Therapeutics Inc |
Treatment of chronic cough, shortness of breath and wheezing
|
|
SG11202100653YA
(en)
|
2018-07-25 |
2021-02-25 |
Daiichi Sankyo Co Ltd |
Effective method for manufacturing antibody-drug conjugate
|
|
WO2020022475A1
(ja)
|
2018-07-27 |
2020-01-30 |
第一三共株式会社 |
抗体-薬物コンジュゲートの薬物部位を認識する蛋白質
|
|
CA3108044A1
(en)
|
2018-07-31 |
2020-02-06 |
Daiichi Sankyo Company, Limited |
Treatment of metastatic brain tumor by administration of antibody-drug conjugate
|
|
EA202190471A1
(ru)
|
2018-08-06 |
2021-05-24 |
Дайити Санкио Компани, Лимитед |
Комбинация конъюгата антитела-лекарственного средства и ингибитора тубулина
|
|
CN112739826A
(zh)
|
2018-08-23 |
2021-04-30 |
第一三共株式会社 |
抗体-药物缀合物的敏感性标志物
|
|
WO2020069011A1
(en)
|
2018-09-25 |
2020-04-02 |
Absci, Llc |
Protein purification methods
|
|
WO2020084503A1
(en)
|
2018-10-26 |
2020-04-30 |
Cadila Healthcare Limited |
A composition comprising antibody with reduced level of basic variants thereof
|
|
KR102905497B1
(ko)
|
2018-12-11 |
2025-12-30 |
다이이찌 산쿄 가부시키가이샤 |
항체-약물 컨쥬게이트와 parp 저해제의 조합
|
|
JP7624922B2
(ja)
|
2018-12-19 |
2025-01-31 |
インサイト・コーポレイション |
胃腸疾患の治療のためのjak1経路阻害剤
|
|
US20220040324A1
(en)
|
2018-12-21 |
2022-02-10 |
Daiichi Sankyo Company, Limited |
Combination of antibody-drug conjugate and kinase inhibitor
|
|
BR112021014662A2
(pt)
|
2019-02-01 |
2021-09-21 |
Glaxosmithkline Intellectual Property Development Limited |
Tratamentos de combinação para o câncer que compreendem belantamab mafodotin e um anticorpo anti ox40 e usos e métodos dos mesmos
|
|
TWI856084B
(zh)
|
2019-04-01 |
2024-09-21 |
美商建南德克公司 |
用於穩定含有蛋白質之配方之組合物及方法
|
|
CN112007169B
(zh)
*
|
2019-05-30 |
2022-03-08 |
湖南大学 |
一种核酸适配体药物偶联物及其制备方法和用途
|
|
CN110205302B
(zh)
*
|
2019-06-24 |
2021-03-23 |
扬州大学 |
一株分泌抗麦考酚酸单克隆抗体的细胞株、其单克隆抗体及其应用
|
|
EP3990494A1
(en)
|
2019-06-26 |
2022-05-04 |
GlaxoSmithKline Intellectual Property Development Limited |
Il1rap binding proteins
|
|
CN110551214A
(zh)
*
|
2019-08-27 |
2019-12-10 |
杨澜 |
一种人源化抗Periostin单克隆抗体、及其制备方法和应用
|
|
IL294601A
(en)
|
2020-01-10 |
2022-09-01 |
Trevi Therapeutics Inc |
Methods of administration of nalbuphine
|
|
JP2023512023A
(ja)
|
2020-01-28 |
2023-03-23 |
グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッド |
併用療法及びその使用及び方法
|
|
IL295434A
(en)
|
2020-02-21 |
2022-10-01 |
Macrogenics Inc |
cd137 binding molecules and their uses
|
|
US20230256110A1
(en)
|
2020-06-24 |
2023-08-17 |
Astrazeneca Uk Limited |
Combination of antibody-drug conjugate and atm inhibitor
|
|
IL299368A
(en)
|
2020-06-24 |
2023-02-01 |
Astrazeneca Uk Ltd |
A combination of an antibody-drug conjugate and an ATR inhibitor
|
|
EP4171654A1
(en)
|
2020-06-24 |
2023-05-03 |
AstraZeneca UK Limited |
Combination of antibody-drug conjugate and cdk9 inhibitor
|
|
WO2021260583A1
(en)
|
2020-06-24 |
2021-12-30 |
Astrazeneca Uk Limited |
Combination of antibody-drug conjugate and dna-pk inhibitor
|
|
WO2021260582A1
(en)
|
2020-06-24 |
2021-12-30 |
Astrazeneca Uk Limited |
Combination of antibody-drug conjugate and aurora b inhibitor
|
|
JP7848119B2
(ja)
|
2020-07-20 |
2026-04-20 |
第一三共株式会社 |
抗her2抗体-薬物コンジュゲートとher二量体化阻害剤の組み合わせ
|
|
JP2023545096A
(ja)
|
2020-10-09 |
2023-10-26 |
アストラゼネカ ユーケー リミテッド |
抗体-薬物コンジュゲート及びparp1選択的阻害薬の組み合わせ
|
|
AU2021378152A1
(en)
|
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