BE2013C020I2 - - Google Patents

Info

Publication number
BE2013C020I2
BE2013C020I2 BE2013C020C BE2013C020C BE2013C020I2 BE 2013C020 I2 BE2013C020 I2 BE 2013C020I2 BE 2013C020 C BE2013C020 C BE 2013C020C BE 2013C020 C BE2013C020 C BE 2013C020C BE 2013C020 I2 BE2013C020 I2 BE 2013C020I2
Authority
BE
Belgium
Application number
BE2013C020C
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22495168&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BE2013C020(I2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of BE2013C020I2 publication Critical patent/BE2013C020I2/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/6807—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug or compound being a sugar, nucleoside, nucleotide, nucleic acid, e.g. RNA antisense
    • A61K47/6809—Antibiotics, e.g. antitumor antibiotics anthracyclins, adriamycin, doxorubicin or daunomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507—Comprising a combination of two or more separate antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
BE2013C020C 1999-06-25 2013-03-08 BE2013C020I2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14131699P 1999-06-25 1999-06-25
PCT/US2000/017366 WO2001000245A2 (fr) 1999-06-25 2000-06-23 Anticorps anti-erbb2 humanises et traitement a l'aide de ces anticorps

Publications (1)

Publication Number Publication Date
BE2013C020I2 true BE2013C020I2 (fr) 2019-08-21

Family

ID=22495168

Family Applications (1)

Application Number Title Priority Date Filing Date
BE2013C020C BE2013C020I2 (fr) 1999-06-25 2013-03-08

Country Status (33)

Country Link
EP (2) EP1189641B1 (fr)
JP (2) JP4283474B2 (fr)
KR (2) KR100850389B1 (fr)
CN (4) CN101518653B (fr)
AR (1) AR024464A1 (fr)
AT (2) AT500848B1 (fr)
AU (2) AU784045B2 (fr)
BE (1) BE2013C020I2 (fr)
BR (2) BRPI0012198B8 (fr)
CA (2) CA2376596C (fr)
CH (1) CH694589A5 (fr)
CY (2) CY1109525T1 (fr)
CZ (1) CZ299702B6 (fr)
DE (2) DE10084743T1 (fr)
DK (1) DK1189641T5 (fr)
ES (1) ES2329437T3 (fr)
FR (1) FR13C0016I2 (fr)
GB (1) GB2368796B (fr)
GE (1) GEP20104998B (fr)
HK (1) HK1044888A1 (fr)
HU (1) HU226742B1 (fr)
IL (3) IL146954A0 (fr)
LU (1) LU92164I2 (fr)
MX (1) MXPA01013458A (fr)
NO (3) NO328377B1 (fr)
NZ (2) NZ516830A (fr)
PL (2) PL204629B1 (fr)
PT (1) PT1189641E (fr)
RU (2) RU2270029C2 (fr)
SI (3) SI1189641T1 (fr)
TR (1) TR200103756T2 (fr)
WO (1) WO2001000245A2 (fr)
ZA (2) ZA200109786B (fr)

Families Citing this family (225)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8038994B2 (en) 1996-05-15 2011-10-18 Quest Pharmatech Inc. Combination therapy for treating disease
JP4780633B2 (ja) * 1999-06-25 2011-09-28 イムノゲン インコーポレーティッド 抗−ＥｒｂＢ抗体−メイタンシノイド複合体を用いた治療方法
CN101518653B (zh) * 1999-06-25 2015-08-19 基因技术股份有限公司 使用抗ErbB抗体-类美坦素偶联物的治疗方法
US6825333B1 (en) 1999-08-20 2004-11-30 Chiron Corporation EGFH2 genes and gene products
KR20110008112A (ko) 1999-08-27 2011-01-25 제넨테크, 인크. 항-ＥｒｂＢ2 항체 투여 치료 방법
JP4776843B2 (ja) 1999-10-01 2011-09-21 イムノゲン インコーポレーティッド 免疫複合体及び化学療法剤を用いる癌治療用組成物及び方法
SI1282443T1 (sl) 2000-05-19 2010-01-29 Genentech Inc Metoda detekcije gena za izboljšanje verjetnosti učinkovitega odziva na terapijo raka z antagonistom ErbB
EP1228766A1 (fr) * 2001-01-31 2002-08-07 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Phosphorylation de PYK2 par HER3 induit l'invasion de tumeurs
AU2002358246B2 (en) * 2001-10-26 2008-02-28 Oncoquest Pharmaceuticals Inc. Combination therapy for treating disease
JP2005535297A (ja) * 2002-04-11 2005-11-24 アムジェン インコーポレイテッド Ｈｅｒ−２レセプターチロシンキナーゼ分子およびその使用
ITTO20020340A1 (it) * 2002-04-19 2003-10-20 Biother Di Contardi Gabriella Localizzazione del recettore her2 mediante anticorpo umanizzato biotinilato.
WO2003101401A2 (fr) 2002-06-03 2003-12-11 Chiron Corporation Utilisation de nrg4, ou d'inhibiteurs de nrg4, dans le traitement du cancer du colon et du pancreas
AT413486B (de) * 2002-07-03 2006-03-15 Igeneon Krebs Immuntherapie Verwendung eines antikörpers gerichtet gegen lewis-antigene
NO340576B1 (no) * 2002-07-11 2017-05-15 Hoffmann La Roche Rekombinant, humanisert antistoff 2C4 (rhuMab 2C4) for anvendelse sammen med et andre, forskjellig vekstinhiberende anti-ErbB2-antistoff i en fremgangsmåte for behandling av kreft i en pasient og anvendelse derav for fremstilling av et medikament
ES2376165T3 (es) 2002-07-15 2012-03-09 F. Hoffmann-La Roche Ag Tratamiento del c�?ncer con el anticuerpo dirigido contra erbb2 rhumab 2c4.
ATE514717T1 (de) 2002-07-18 2011-07-15 Merus B V Rekombinante produktion von antikörpermischungen
USRE47770E1 (en) 2002-07-18 2019-12-17 Merus N.V. Recombinant production of mixtures of antibodies
US7264800B2 (en) 2002-07-18 2007-09-04 Helix Biopharma Corporation Method and composition for inhibiting cancer cell growth
ES2443416T3 (es) * 2002-07-18 2014-02-19 Helix Biopharma Corp. Uso de ureasa para inhibir el crecimiento de células cancerosas
WO2004013180A2 (fr) 2002-08-01 2004-02-12 Immunomedics, Inc. Anticorps anti-alpha-fetoproteine immu31, proteines de fusion et procedes d'utilisation de ceux-ci
US20040033228A1 (en) 2002-08-16 2004-02-19 Hans-Juergen Krause Formulation of human antibodies for treating TNF-alpha associated disorders
CN101972478B (zh) * 2002-10-08 2012-10-31 免疫医疗公司 抗体治疗
WO2004054622A1 (fr) * 2002-12-13 2004-07-01 Immunomedics, Inc. Immunoconjugues comprenant une liaison intracellulaire clivable
EP1613736A4 (fr) * 2003-03-11 2007-04-11 Dana Farber Cancer Inst Inc Inhibition de la pathogenese virale
MXPA05011406A (es) * 2003-04-23 2005-12-12 Medarex Inc Anticuerpos humanizados para el receptor-1 de interferon alfa (ifnar-1).
US8088387B2 (en) 2003-10-10 2012-01-03 Immunogen Inc. Method of targeting specific cell populations using cell-binding agent maytansinoid conjugates linked via a non-cleavable linker, said conjugates, and methods of making said conjugates
AT500651B9 (de) * 2003-05-27 2010-04-15 Altropus Gmbh Aktiv immunisierender antikörper
EP2395016A3 (fr) 2003-05-30 2012-12-19 Merus B.V. Conception et utilisation de régions variables appariées de molécules de liaison spécifiques
US20100069614A1 (en) 2008-06-27 2010-03-18 Merus B.V. Antibody producing non-human mammals
EP3095793B1 (fr) 2003-07-28 2020-03-25 Genentech, Inc. Réduction de protéine a pendant une chromatographie d'affinité sur protéine a
EP1658075A4 (fr) * 2003-08-29 2008-03-05 Cedars Sinai Medical Center Composition et methode pour le traitement de cancers et d'autres troubles physiologiques, fondees sur la regulation de la voie ppar-gamma et de l'axe de la her-kinase
CN101048425B (zh) * 2003-09-18 2012-12-26 雷文生物技术公司 Kid3及与其结合的kid3抗体
BRPI0416987A (pt) * 2003-11-28 2007-08-21 Mitra Medical Technology Ab direcionamento de antìgenos de erb
MXPA06014065A (es) * 2004-06-01 2007-01-31 Genentech Inc Conjugados de droga-anticuerpo y metodos.
SV2006002143A (es) * 2004-06-16 2006-01-26 Genentech Inc Uso de un anticuerpo para el tratamiento del cancer resistente al platino
ZA200701234B (en) 2004-07-22 2008-12-31 Genentech Inc HER2 antibody composition
US20100111856A1 (en) 2004-09-23 2010-05-06 Herman Gill Zirconium-radiolabeled, cysteine engineered antibody conjugates
JP4948413B2 (ja) 2004-09-23 2012-06-06 ジェネンテック， インコーポレイテッド システイン操作抗体および結合体
JO3000B1 (ar) 2004-10-20 2016-09-05 Genentech Inc مركبات أجسام مضادة .
KR20070085855A (ko) * 2004-12-07 2007-08-27 제넨테크, 인크. Ｈｅｒ 억제제를 이용한 치료를 위한 환자 선택 방법
CA2592177A1 (fr) * 2005-01-21 2006-07-27 Genentech, Inc. Dosage fixe d'anticorps anti-her
BRPI0606542A8 (pt) 2005-02-23 2018-03-20 Genentech Inc métodos para aumentar o tempo de progressão de uma doença (ttp)
AR053272A1 (es) * 2005-05-11 2007-04-25 Hoffmann La Roche Determinacion de responsivos a la quimioterapia
WO2006132788A2 (fr) 2005-06-06 2006-12-14 Genentech, Inc. Nouvelles disruptions geniques, nouvelles compositions et nouveaux procedes s'y rapportant
US7700299B2 (en) 2005-08-12 2010-04-20 Hoffmann-La Roche Inc. Method for predicting the response to a treatment
EP1922410A2 (fr) 2005-08-15 2008-05-21 Genentech, Inc. Disruptions et compositions géniques et procédés associés
KR101164820B1 (ko) 2005-09-22 2012-07-12 삼성전자주식회사 디스플레이장치
US8080534B2 (en) 2005-10-14 2011-12-20 Phigenix, Inc Targeting PAX2 for the treatment of breast cancer
EP1962584A2 (fr) 2005-11-21 2008-09-03 Genentech, Inc. Nouvelles dissociations de gènes, compositions et procédés les concernant
AR056857A1 (es) 2005-12-30 2007-10-24 U3 Pharma Ag Anticuerpos dirigidos hacia her-3 (receptor del factor de crecimiento epidérmico humano-3) y sus usos
JO2660B1 (en) 2006-01-20 2012-06-17 نوفارتيس ايه جي Pi-3 inhibitors and methods of use
JP2009527227A (ja) 2006-02-17 2009-07-30 ジェネンテック・インコーポレーテッド 遺伝子破壊、それに関連する組成物および方法
TW200812615A (en) 2006-03-22 2008-03-16 Hoffmann La Roche Tumor therapy with an antibody for vascular endothelial growth factor and an antibody for human epithelial growth factor receptor type 2
AR060358A1 (es) 2006-04-06 2008-06-11 Novartis Vaccines & Diagnostic Quinazolinas para la inhibicion de pdk 1
JP2009536022A (ja) 2006-04-19 2009-10-08 ジェネンテック・インコーポレーテッド 新規の遺伝子破壊、それに関連する組成物および方法
US8524865B2 (en) 2006-05-30 2013-09-03 Genentech, Inc. Antibodies and immunoconjugates and uses therefor
MX2008015581A (es) * 2006-06-05 2008-12-17 Genentech Inc Prolongacion de la supervivencia de pacientes con cancer con niveles elevados de egf o tgf-alfa.
PL2056874T3 (pl) 2006-08-21 2013-02-28 Hoffmann La Roche Leczenie nowotworu przeciwciałem przeciw VEGF
WO2008031531A1 (fr) * 2006-09-15 2008-03-20 F. Hoffmann-La Roche Ag Thérapie antitumorale avec une combinaison d'anticorps anti-her2
CN103396486A (zh) * 2006-10-12 2013-11-20 中外制药株式会社 使用抗ereg抗体的癌症的诊断和治疗
KR101541550B1 (ko) 2006-10-27 2015-08-04 제넨테크, 인크. 항체 및 면역접합체 및 이들의 용도
CA2677108A1 (fr) * 2007-03-02 2008-09-12 Genentech, Inc. Element de prevision de la reponse a un inhibiteur de her
US9551033B2 (en) 2007-06-08 2017-01-24 Genentech, Inc. Gene expression markers of tumor resistance to HER2 inhibitor treatment
CA3006428A1 (fr) 2007-06-08 2008-12-18 Genentech, Inc. Marqueurs d'expression de gene de resistance tumorale a un traiteme r inhibiteur her2
CN101918844A (zh) * 2007-06-18 2010-12-15 米迪缪尼有限公司 表达epha2和erbb2的细胞的协同治疗
ES2528922T3 (es) 2007-07-16 2015-02-13 Genentech, Inc. Anticuerpos anti-CD79b humanizados e inmunoconjugados y métodos de uso
KR101486615B1 (ko) 2007-07-16 2015-01-28 제넨테크, 인크. 항-ｃｄ７９ｂ 항체 및 면역접합체 및 사용 방법
KR20140015166A (ko) 2007-10-30 2014-02-06 제넨테크, 인크. 양이온 교환 크로마토그래피에 의한 항체 정제
EP2215123A1 (fr) * 2007-11-27 2010-08-11 Ablynx N.V. Constructions d'immunoglobuline
UY31545A1 (es) 2007-12-20 2009-08-03 Nuevos derivados de 2-carboxamida cianoaminourea, sus sales y profarmacos farmacéuticamente aceptables, procesos de preparacion y aplicaciones
PE20091174A1 (es) * 2007-12-27 2009-08-03 Chugai Pharmaceutical Co Ltd Formulacion liquida con contenido de alta concentracion de anticuerpo
US8454960B2 (en) 2008-01-03 2013-06-04 The Scripps Research Institute Multispecific antibody targeting and multivalency through modular recognition domains
US8574577B2 (en) 2008-01-03 2013-11-05 The Scripps Research Institute VEGF antibodies comprising modular recognition domains
US8557242B2 (en) 2008-01-03 2013-10-15 The Scripps Research Institute ERBB2 antibodies comprising modular recognition domains
US8557243B2 (en) 2008-01-03 2013-10-15 The Scripps Research Institute EFGR antibodies comprising modular recognition domains
NZ586701A (en) 2008-01-03 2013-07-26 Scripps Research Inst Antibody targeting through a modular recognition domain (MRD) wherein the MRD targets angiopoietin-2 (ANG-2)
TWI472339B (zh) 2008-01-30 2015-02-11 Genentech Inc 包含結合至ｈｅｒ２結構域ii之抗體及其酸性變異體的組合物
TWI607019B (zh) 2008-01-31 2017-12-01 建南德克公司 抗－ｃｄ７９ｂ抗體及免疫共軛物及使用方法
KR101881168B1 (ko) * 2008-03-14 2018-07-24 제넨테크, 인크. 약물 저항성과 관련된 유전적 변이
CA2990929C (fr) * 2008-03-18 2022-04-12 Genentech, Inc. Combinaisons de conjugues anticorps anti-her2-medicament et d'agents chimiotherapiques, et procedes d'utilisation
ES2616728T3 (es) 2008-05-23 2017-06-14 Siwa Corporation Procedimientos y composiciones para facilitar la regeneración
BRPI0812682A2 (pt) 2008-06-16 2010-06-22 Genentech Inc tratamento de cáncer de mama metastático
MX2011002372A (es) 2008-09-10 2011-04-04 Genentech Inc Composiciones y metodos para la prevencion de la degradacion oxidativa de proteinas.
PL2396036T3 (pl) 2009-02-13 2017-12-29 Immunomedics, Inc. Immunokoniugaty z połączeniem rozszczepialnym wewnątrzkomórkowo
US20120121596A1 (en) 2009-03-20 2012-05-17 Germaine Fuh Bispecific anti-her antibodies
BRPI1012676A2 (pt) 2009-04-01 2016-04-05 Genentech Inc anticorpos anti-fcrh5 e imunoconjugados e métodos de uso
WO2010115553A1 (fr) 2009-04-07 2010-10-14 Roche Glycart Ag Anticorps anti-erbb-2/anti-c-met bispécifiques
WO2010136569A1 (fr) 2009-05-29 2010-12-02 F. Hoffmann-La Roche Ag Modulateurs de la signalisation her2 chez des patients exprimant her2 souffrant d'un cancer de l'estomac
US20120141501A1 (en) 2009-05-29 2012-06-07 Forerunner Pharma Research Co. Ltd Pharmaceutical Composition Containing Antagonist of EGF Family Ligand as Component
US8293753B2 (en) 2009-07-02 2012-10-23 Novartis Ag Substituted 2-carboxamide cycloamino ureas
US9345661B2 (en) 2009-07-31 2016-05-24 Genentech, Inc. Subcutaneous anti-HER2 antibody formulations and uses thereof
KR101822205B1 (ko) 2009-08-11 2018-01-25 제넨테크, 인크. 글루타민-비함유 세포 배양 배지에서의 단백질의 생성
CN102573909A (zh) * 2009-08-15 2012-07-11 霍夫曼-拉罗奇有限公司 抗血管发生疗法用于治疗先前治疗过的乳腺癌
ES2787234T3 (es) 2009-09-01 2020-10-15 Hoffmann La Roche Purificación de proteínas potenciada a través de una elución de proteína A modificada
AR078161A1 (es) 2009-09-11 2011-10-19 Hoffmann La Roche Formulaciones farmaceuticas muy concentradas de un anticuerpo anti cd20. uso de la formulacion. metodo de tratamiento.
DK2486141T3 (en) 2009-10-07 2018-04-23 Macrogenics Inc FC-REGION-CONTAINING POLYPEPTIDES THAT PROVIDE IMPROVED EFFECTOR FUNCTION BASED ON CHANGES OF THE SCOPE OF FUCOSYLATION AND PROCEDURES FOR THEIR USE
EP2493929B1 (fr) * 2009-10-28 2017-08-16 AbbVie Biotherapeutics Inc. Anticorps anti-egfr et leurs utilisations
SI2496601T1 (sl) 2009-11-05 2017-09-29 F. Hoffmann-La Roche Ag Tehnike in sestavek za sekrecijo heterolognih polipeptidov
RS60390B1 (sr) 2009-11-13 2020-07-31 Daiichi Sankyo Europe Gmbh Materijal i postupci za lečenje ili prevenciju bolesti povezanih sa her-3
MX2012006406A (es) 2009-12-04 2012-07-25 Genentech Inc Anticuerpos multiespecificos, analogos de anticuerpo, composiciones y metodos.
CA2788715C (fr) * 2010-02-04 2021-06-08 Toray Industries, Inc. Composition pharmaceutique pour le traitement et/ou la prevention du cancer
MY160556A (en) * 2010-02-18 2017-03-15 Genentech Inc Neuregulin antagonists and use thereof in treating cancer
US8609095B2 (en) 2010-03-04 2013-12-17 Symphogen A/S Anti-HER2 antibodies and compositions
MX354867B (es) 2010-03-22 2018-03-23 Genentech Inc Star Composiciones y métodos útiles para estabilizar formulaciones que contienen proteína.
JP2013525484A (ja) 2010-05-03 2013-06-20 ジェネンテック， インコーポレイテッド タンパク質含有製剤の粘度を低減させるために有用な組成物及び方法
WO2011146568A1 (fr) 2010-05-19 2011-11-24 Genentech, Inc. Prédiction de réponses à un inhibiteur de her
IL299365A (en) 2010-05-27 2023-02-01 Genmab As Monoclonal antibodies against 2HER
NZ604007A (en) 2010-05-27 2015-03-27 Genmab As Monoclonal antibodies against her2 epitope
KR20190067277A (ko) 2010-05-28 2019-06-14 제넨테크, 인크. 락테이트 데히드로게나제 및 피루베이트 데히드로게나제 키나제의 발현의 하향조절에 의한 락테이트 수준의 감소 및 폴리펩티드 생산의 증가
RU2613886C2 (ru) 2010-06-03 2017-03-21 Дженентек, Инк. Антитела и иммуноконъюгаты, визуализируемые при помощи иммуно-позитрон-эмиссионной томографии, и способы их применения
RU2626537C2 (ru) 2010-06-08 2017-07-28 Дженентек, Инк. Полученные с помощью генной инженерии антитела с цистеиновыми заменами и их конъюгаты
CA2802756C (fr) 2010-06-24 2021-05-04 Genentech, Inc. Compositions et methodes pour stabiliser des preparations contenant des proteines
US20120100166A1 (en) 2010-07-15 2012-04-26 Zyngenia, Inc. Ang-2 Binding Complexes and Uses Thereof
AR082418A1 (es) 2010-08-02 2012-12-05 Novartis Ag Formas cristalinas de 1-(4-metil-5-[2-(2,2,2-trifluoro-1,1-dimetil-etil)-piridin-4-il]-tiazol-2-il)-amida de 2-amida del acido (s)-pirrolidin-1,2-dicarboxilico
TW201302793A (zh) 2010-09-03 2013-01-16 Glaxo Group Ltd 新穎之抗原結合蛋白
US8721571B2 (en) 2010-11-22 2014-05-13 Siwa Corporation Selective removal of cells having accumulated agents
EP2643353A1 (fr) 2010-11-24 2013-10-02 Novartis AG Molécules multi-spécifiques
JP5838221B2 (ja) 2010-12-21 2016-01-06 エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト アイソフォーム濃縮抗体調製物及びこれを得る方法
WO2012085113A1 (fr) 2010-12-23 2012-06-28 Roche Diagnostics Gmbh Agent de liaison
SG191153A1 (en) 2010-12-23 2013-07-31 Hoffmann La Roche Polypeptide-polynucleotide-complex and its use in targeted effector moiety delivery
AU2012213080B2 (en) 2011-01-31 2014-03-27 Novartis Ag Novel heterocyclic derivatives
CN103649326B (zh) * 2011-03-08 2016-08-17 宾夕法尼亚大学理事会 用于治疗和诊断用途的抗体样蛋白
US20140170149A1 (en) 2011-04-20 2014-06-19 Genmab A/S Bispecific antibodies against her2 and cd3
CN103857699B (zh) 2011-05-24 2016-08-31 泽恩格尼亚股份有限公司 多价和单价多特异性复合物及其用途
BR112014003431A2 (pt) 2011-08-17 2017-06-13 Genentech Inc anticorpo, ácido nucleico, célula hospedeira, método de produção de um anticorpo, imunoconjugado, formulação farmacêutica, agente farmacêutico, uso do anticorpo, método de tratamento de um indivíduo que tem câncer e método de aumento de tempo para recorrência de tumor
KR102099991B1 (ko) 2011-10-14 2020-04-14 제넨테크, 인크. Her2 이량체화 억제제인 페르투주맙의 용도 및 이를 포함하는 제조품
WO2013063229A1 (fr) 2011-10-25 2013-05-02 The Regents Of The University Of Michigan Traitement par un agent de ciblage de her2 dans des cancers non amplifiés par her2 ayant des cellules souches cancéreuses exprimant her2
KR20140090218A (ko) 2011-10-28 2014-07-16 노파르티스 아게 신규 퓨린 유도체 및 질환의 치료에서의 그의 용도
EP2797957B1 (fr) 2011-11-23 2019-06-19 MedImmune, LLC Molécules de liaison propres à her3 et utilisation de celles-ci
CN104271761B (zh) 2011-11-30 2017-03-15 霍夫曼-拉罗奇有限公司 癌症中的erbb3突变
EP2788500A1 (fr) 2011-12-09 2014-10-15 F.Hoffmann-La Roche Ag Identification de non-répondeurs aux inhibiteurs de her2
AU2012355356B2 (en) 2011-12-22 2017-10-12 Genentech, Inc. Ion exchange membrane chromatography
TWI593705B (zh) 2011-12-28 2017-08-01 Chugai Pharmaceutical Co Ltd Humanized anti-epiregulin antibody and cancer therapeutic agent containing the antibody as an active ingredient
EP3045543A3 (fr) 2012-01-31 2016-10-12 Novartis AG Procédé de traitement du cancer
EP2638916A1 (fr) 2012-03-16 2013-09-18 Covagen AG Nouvelles molécules de liaison ayant une activité antitumorale
JP2015514710A (ja) 2012-03-27 2015-05-21 ジェネンテック， インコーポレイテッド Ｈｅｒ３阻害剤に関する診断及び治療
US9248181B2 (en) 2012-04-20 2016-02-02 Merus B.V. Methods and means for the production of Ig-like molecules
KR101505157B1 (ko) * 2012-05-08 2015-03-24 주식회사 종근당 항―ＥｒｂＢ２ 항체 변이체
NZ700924A (en) 2012-05-16 2016-02-26 Novartis Ag Dosage regimen for a pi-3 kinase inhibitor
KR102291355B1 (ko) 2012-11-30 2021-08-19 에프. 호프만-라 로슈 아게 Pd-l1 억제제 공동치료를 필요로 하는 환자의 식별방법
US20150329524A1 (en) 2013-01-10 2015-11-19 Glaxosmithkline Intellectual Property (No.2) Limited Fatty acid synthase inhibitors
US9180185B2 (en) 2013-01-11 2015-11-10 Hoffman-La Roche Inc. Combination therapy of anti-HER3 antibodies
EP3424530A1 (fr) 2013-03-15 2019-01-09 Zyngenia, Inc. Complexes multispécifiques monovalents et multivalents et leurs utilisations
CN104628846B (zh) 2013-11-06 2019-12-06 三生国健药业（上海）股份有限公司 重组蛋白质的纯化方法
CN110240655B (zh) 2013-11-19 2023-05-16 荣昌生物制药(烟台)股份有限公司 抗her2抗体及其缀合物
EP3074424A4 (fr) 2013-11-27 2017-06-14 Zymeworks Inc. Produits de recombinaison de liaison à l'antigène bispécifiques ciblant her2
MX2016007376A (es) 2013-12-06 2017-05-11 Novartis Ag Regimen de dosificacion para un inhibidor selectivo alfa-isomorfo de fosfatidilinositol 3-quinasa.
BR112016013482B1 (pt) 2014-01-31 2022-04-19 Daiichi Sankyo Company, Limited Conjugado de anticorpo anti-her2-fármaco, fármacos antitumor e/ou anticâncer e composição farmacêutica
EP3111222A1 (fr) 2014-02-26 2017-01-04 Glaxosmithkline Intellectual Property (No. 2) Limited Méthodes de traitement de patients atteints de cancer réagissant à l'inhibiteur d'ezh2 gsk126
JP6644717B2 (ja) 2014-03-14 2020-02-12 ジェネンテック， インコーポレイテッド 異種ポリペプチドを分泌させるための方法及び組成物
JP2017512765A (ja) 2014-04-11 2017-05-25 メディミューン，エルエルシー 二重特異性ｈｅｒ２抗体
KR20170052600A (ko) 2014-09-12 2017-05-12 제넨테크, 인크. 시스테인 가공된 항체 및 콘주게이트
US10385380B2 (en) 2014-10-02 2019-08-20 The Regents Of The University Of California Personalized protease assay to measure protease activity in neoplasms
US9993535B2 (en) 2014-12-18 2018-06-12 Siwa Corporation Method and composition for treating sarcopenia
US10358502B2 (en) 2014-12-18 2019-07-23 Siwa Corporation Product and method for treating sarcopenia
MA41414A (fr) 2015-01-28 2017-12-05 Centre Nat Rech Scient Protéines de liaison agonistes d' icos
KR101515535B1 (ko) 2015-01-28 2015-05-06 주식회사 종근당 항―ＥｒｂＢ２ 항체 변이체
US11028182B2 (en) 2015-05-13 2021-06-08 Zymeworks Inc. Antigen-binding constructs targeting HER2
WO2017025871A1 (fr) 2015-08-07 2017-02-16 Glaxosmithkline Intellectual Property Development Limited Polythérapie comprenant des anticorps anti-ctla-4
KR20180056689A (ko) * 2015-10-13 2018-05-29 시와 코퍼레이션 항-age 항체 및 이의 사용 방법
AU2016347881A1 (en) 2015-11-02 2018-05-10 Novartis Ag Dosage regimen for a phosphatidylinositol 3-kinase inhibitor
CN106729743B (zh) 2015-11-23 2021-09-21 四川科伦博泰生物医药股份有限公司 抗ErbB2抗体-药物偶联物及其组合物、制备方法和应用
CN108884161A (zh) 2015-12-01 2018-11-23 葛兰素史密斯克莱知识产权发展有限公司 联合治疗及其用途和方法
AU2016370376B2 (en) 2015-12-14 2023-12-14 Macrogenics, Inc. Bispecific molecules having immunoreactivity with PD-1 and CTLA-4, and methods of use thereof
CN105646704B (zh) * 2015-12-28 2019-11-15 广西医科大学 抗p185erbB2人鼠嵌合抗体ChAb26、乳腺特异性表达载体、转基因FVB小鼠及其制备方法
CA3021150C (fr) 2016-02-19 2023-02-07 Siwa Corporation Procede et composition pour traiter le cancer, detruire les cellules cancereuses metastatiques et prevenir la metastase cancereuse en utilisant des anticorps contre les produits t erminaux de glycation avancee (age)
KR20180119570A (ko) * 2016-03-15 2018-11-02 메리맥 파마슈티컬즈, 인크. 항-ErbB3 항체를 포함하는 병용 요법을 이용한 ER+, HER2-, HRG+ 유방암의 치료
KR20180133452A (ko) 2016-04-15 2018-12-14 시와 코퍼레이션 신경퇴행성 질환을 치료하기 위한 항-노화 항체
WO2017194554A1 (fr) 2016-05-10 2017-11-16 Inserm (Institut National De La Sante Et De La Recherche Medicale) Polythérapies pour le traitement du cancer
WO2017196263A1 (fr) * 2016-05-12 2017-11-16 Agency For Science, Technology And Research Anticorps anti-erbb2 et utilisations correspondantes
US11213585B2 (en) 2016-06-23 2022-01-04 Siwa Corporation Vaccines for use in treating various diseases and disorders
WO2018060833A1 (fr) 2016-09-27 2018-04-05 Novartis Ag Schéma posologique pour l'alpelisib, un inhibiteur de la phosphatidylinositol 3-kinase spécifique de l'isoforme alpha
US20190330368A1 (en) 2016-10-07 2019-10-31 Daiichi Sankyo Company, Limited Therapy for drug-resistant cancer by administration of anti-her2 antibody/drug conjugate
EP3552626A4 (fr) 2016-12-12 2020-06-10 Daiichi Sankyo Company, Limited Association d'un conjugué anticorps-médicament et d'un inhibiteur de point de contrôle immunitaire
US10858449B1 (en) 2017-01-06 2020-12-08 Siwa Corporation Methods and compositions for treating osteoarthritis
US10995151B1 (en) 2017-01-06 2021-05-04 Siwa Corporation Methods and compositions for treating disease-related cachexia
US10961321B1 (en) 2017-01-06 2021-03-30 Siwa Corporation Methods and compositions for treating pain associated with inflammation
EP3565845A4 (fr) * 2017-01-06 2020-10-07 Biosion, Inc. Anticorps erbb2 et leurs utilisations
US10925937B1 (en) 2017-01-06 2021-02-23 Siwa Corporation Vaccines for use in treating juvenile disorders associated with inflammation
EP3585431A4 (fr) 2017-02-24 2020-12-16 MacroGenics, Inc. Molécules de liaison bispécifiques capables de se lier à cd137 et à des antigènes tumoraux, et leurs utilisations
WO2018160138A1 (fr) 2017-03-02 2018-09-07 Aslan Pharmaceuticals Pte Ltd Inhibiteur de dhodh pour le traitement du cancer hématologique
EP3589661B1 (fr) 2017-03-02 2023-11-01 Genentech, Inc. Traitement par adjuvants du cancer du sein her2 positif
AR111249A1 (es) 2017-03-22 2019-06-19 Genentech Inc Composiciones de anticuerpo optimizadas para el tratamiento de trastornos oculares
EP3609923A1 (fr) 2017-04-13 2020-02-19 Siwa Corporation Anticorps monoclonal humanisé de produit final de glycation avancée
WO2018222135A1 (fr) 2017-06-02 2018-12-06 Aslan Pharmaceuticals Pte Ltd Cancérothérapie
CN107417791B (zh) * 2017-08-17 2020-09-22 合肥瀚科迈博生物技术有限公司 抗人ErbB2双特异性抗体、其制备方法及用途
CN110944667A (zh) 2017-08-23 2020-03-31 第一三共株式会社 抗体-药物缀合物制剂及其冻干
BR112020003466B1 (pt) 2017-08-31 2023-12-12 Daiichi Sankyo Company, Limited Métodos de produção de composto, e, composto
WO2019044947A1 (fr) 2017-08-31 2019-03-07 第一三共株式会社 Procédé amélioré de production d'un conjugué anticorps-médicament
CN107789631B (zh) * 2017-11-03 2021-03-16 合肥瀚科迈博生物技术有限公司 抗人ErbB2双表位抗体-药物偶联物及其应用
CA3085432A1 (fr) 2017-12-12 2019-06-20 Macrogenics Inc. Derives de molecules de liaison a cd-16 bispecifiques et leur utilisation dans le traitement de maladies
US11518801B1 (en) 2017-12-22 2022-12-06 Siwa Corporation Methods and compositions for treating diabetes and diabetic complications
US11685781B2 (en) 2018-02-15 2023-06-27 Macrogenics, Inc. Variant CD3-binding domains and their use in combination therapies for the treatment of disease
EP3560945A1 (fr) 2018-04-27 2019-10-30 F. Hoffmann-La Roche AG Procédés de purification de polypeptides utilisant des polysorbates
AU2019278628A1 (en) 2018-05-28 2021-01-07 Daiichi Sankyo Company, Limited Treatment of HER2-mutated cancer by administering anti-HER2 antibody-drug conjugate
CA3106995A1 (fr) 2018-07-23 2020-01-30 Trevi Therapeutics, Inc. Traitement de la toux chronique, de l'essoufflement ou de la dyspnee a l'aide de compositions de nalbuphine
US20210283269A1 (en) 2018-07-25 2021-09-16 Daiichi Sankyo Company, Limited Effective method for manufacturing antibody-drug conjugate
AU2019311596A1 (en) 2018-07-27 2021-01-28 Daiichi Sankyo Company, Limited Protein recognizing drug moiety of antibody-drug conjugate
CA3108044A1 (fr) 2018-07-31 2020-02-06 Daiichi Sankyo Company, Limited Traitement d'une tumeur cerebrale metastatique par administration d'un conjugue anticorps-medicament
EP3834843A4 (fr) 2018-08-06 2022-05-11 Daiichi Sankyo Company, Limited Association d'un conjugué anticorps-médicament et d'un inhibiteur de tubuline
TW202016317A (zh) 2018-08-23 2020-05-01 日商第一三共股份有限公司 抗體藥物結合物之感受性標記
EP3856760A1 (fr) 2018-09-25 2021-08-04 AbSci, LLC Procédés de purification de protéines
WO2020084503A1 (fr) 2018-10-26 2020-04-30 Cadila Healthcare Limited Composition comprenant un anticorps ayant un niveau réduit de variants basiques de celui-ci
SG11202106248XA (en) 2018-12-11 2021-07-29 Daiichi Sankyo Co Ltd Combination of antibody-drug conjugate with parp inhibitor
SG11202106635WA (en) 2018-12-21 2021-07-29 Daiichi Sankyo Co Ltd Combination of antibody-drug conjugate and kinase inhibitor
WO2020160375A1 (fr) 2019-02-01 2020-08-06 Glaxosmithkline Intellectual Property Development Limited Polythérapies contre le cancer faisant intervenir de la belantamab mafodotine et un anticorps anti-ox40, utilisations et méthodes associées
TW202102266A (zh) 2019-04-01 2021-01-16 美商建南德克公司 用於穩定含有蛋白質之配方之組合物及方法
CN112007169B (zh) * 2019-05-30 2022-03-08 湖南大学 一种核酸适配体药物偶联物及其制备方法和用途
CN110205302B (zh) * 2019-06-24 2021-03-23 扬州大学 一株分泌抗麦考酚酸单克隆抗体的细胞株、其单克隆抗体及其应用
EP3990494A1 (fr) 2019-06-26 2022-05-04 GlaxoSmithKline Intellectual Property Development Limited Protéines de liaison à l'il1rap
CN110551214A (zh) * 2019-08-27 2019-12-10 杨澜 一种人源化抗Periostin单克隆抗体、及其制备方法和应用
JP2023512023A (ja) 2020-01-28 2023-03-23 グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッド 併用療法及びその使用及び方法
WO2021260582A1 (fr) 2020-06-24 2021-12-30 Astrazeneca Uk Limited Association d'un conjugué anticorps-médicament et d'un inhibiteur d'aurora b
KR20230043109A (ko) 2020-06-24 2023-03-30 아스트라제네카 유케이 리미티드 항체-약물 접합체 및 atr 억제제의 조합
WO2021260583A1 (fr) 2020-06-24 2021-12-30 Astrazeneca Uk Limited Association d'un conjugué anticorps-médicament et d'un inhibiteur de la dna-pk
EP4171651A1 (fr) 2020-06-24 2023-05-03 AstraZeneca UK Limited Combinaison d'un conjugué anticorps-médicament et d'un inhibiteur de l'atm
WO2021260578A1 (fr) 2020-06-24 2021-12-30 Astrazeneca Uk Limited Combinaison d'un conjugué anticorps-médicament et d'un inhibiteur de cdk9
JPWO2022019259A1 (fr) 2020-07-20 2022-01-27
CA3195117A1 (fr) 2020-10-09 2022-04-14 Jerome Thomas Mettetal Ii Association d'un anticorps conjugue et d'un inhibiteur selectif de la parp1
CN116916919A (zh) 2020-11-11 2023-10-20 第一三共株式会社 抗体-药物缀合物与抗SIRPα抗体的组合
WO2023126822A1 (fr) 2021-12-28 2023-07-06 Astrazeneca Uk Limited Association d'un conjugué anticorps-médicament et d'un inhibiteur de rasg12c
WO2023209591A1 (fr) 2022-04-27 2023-11-02 Daiichi Sankyo Company, Limited Combinaison d'un conjugué anticorps-médicament avec un inhibiteur de l'ezh1 et/ou de l'ezh2
WO2023218378A1 (fr) 2022-05-11 2023-11-16 Daiichi Sankyo Company, Limited Association combinant un anticorps spécifique d'un antigène tumoral et un inhibiteur de cd47
WO2024023750A1 (fr) 2022-07-28 2024-02-01 Astrazeneca Uk Limited Association d'un conjugué anticorps-médicament et d'un inhibiteur de point de contrôle bispécifique
CN117224689B (zh) * 2023-11-16 2024-02-23 上海复宏汉霖生物技术股份有限公司 联合抗her2抗体和化疗剂治疗胃癌的用途

Family Cites Families (105)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3773919A (en) 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures
CU22545A1 (es) 1994-11-18 1999-03-31 Centro Inmunologia Molecular Obtención de un anticuerpo quimérico y humanizado contra el receptor del factor de crecimiento epidérmico para uso diagnóstico y terapéutico
USRE30985E (en) 1978-01-01 1982-06-29 Serum-free cell culture media
FR2413974A1 (fr) 1978-01-06 1979-08-03 David Bernard Sechoir pour feuilles imprimees par serigraphie
US4275149A (en) 1978-11-24 1981-06-23 Syva Company Macromolecular environment control in specific receptor assays
US4318980A (en) 1978-04-10 1982-03-09 Miles Laboratories, Inc. Heterogenous specific binding assay employing a cycling reactant as label
WO1981001145A1 (fr) 1979-10-18 1981-04-30 Univ Illinois Medicaments "pro-drugs" pouvant etre actives par des enzymes hydrolytiques
US4419446A (en) 1980-12-31 1983-12-06 The United States Of America As Represented By The Department Of Health And Human Services Recombinant DNA process utilizing a papilloma virus DNA as a vector
US4485045A (en) 1981-07-06 1984-11-27 Research Corporation Synthetic phosphatidyl cholines useful in forming liposomes
NZ201705A (en) 1981-08-31 1986-03-14 Genentech Inc Recombinant dna method for production of hepatitis b surface antigen in yeast
US4601978A (en) 1982-11-24 1986-07-22 The Regents Of The University Of California Mammalian metallothionein promoter system
US4560655A (en) 1982-12-16 1985-12-24 Immunex Corporation Serum-free cell culture medium and process for making same
US4657866A (en) 1982-12-21 1987-04-14 Sudhir Kumar Serum-free, synthetic, completely chemically defined tissue culture media
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
DD266710A3 (de) 1983-06-06 1989-04-12 Ve Forschungszentrum Biotechnologie Verfahren zur biotechnischen Herstellung van alkalischer Phosphatase
US4544545A (en) 1983-06-20 1985-10-01 Trustees University Of Massachusetts Liposomes containing modified cholesterol for organ targeting
US4767704A (en) 1983-10-07 1988-08-30 Columbia University In The City Of New York Protein-free culture medium
US4933294A (en) 1984-01-30 1990-06-12 Icrf Patents Limited Method of detecting truncated epidermal growth factor receptors
US4943533A (en) 1984-03-01 1990-07-24 The Regents Of The University Of California Hybrid cell lines that produce monoclonal antibodies to epidermal growth factor receptor
US4965199A (en) 1984-04-20 1990-10-23 Genentech, Inc. Preparation of functional human factor VIII in mammalian cells using methotrexate based selection
US4879231A (en) 1984-10-30 1989-11-07 Phillips Petroleum Company Transformation of yeasts of the genus pichia
US4737456A (en) 1985-05-09 1988-04-12 Syntex (U.S.A.) Inc. Reducing interference in ligand-receptor binding assays
GB8516415D0 (en) 1985-06-28 1985-07-31 Celltech Ltd Culture of animal cells
US4676980A (en) 1985-09-23 1987-06-30 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Target specific cross-linked heteroantibodies
US4927762A (en) 1986-04-01 1990-05-22 Cell Enterprises, Inc. Cell culture medium with antioxidant
GB8610600D0 (en) 1986-04-30 1986-06-04 Novo Industri As Transformation of trichoderma
US5401638A (en) 1986-06-04 1995-03-28 Oncogene Science, Inc. Detection and quantification of neu related proteins in the biological fluids of humans
US5567610A (en) 1986-09-04 1996-10-22 Bioinvent International Ab Method of producing human monoclonal antibodies and kit therefor
US4968603A (en) 1986-12-31 1990-11-06 The Regents Of The University Of California Determination of status in neoplastic disease
IL85035A0 (en) 1987-01-08 1988-06-30 Int Genetic Eng Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same
GB8705477D0 (en) 1987-03-09 1987-04-15 Carlton Med Prod Drug delivery systems
US4975278A (en) 1988-02-26 1990-12-04 Bristol-Myers Company Antibody-enzyme conjugates in combination with prodrugs for the delivery of cytotoxic agents to tumor cells
US4892538A (en) 1987-11-17 1990-01-09 Brown University Research Foundation In vivo delivery of neurotransmitters by implanted, encapsulated cells
US5283187A (en) 1987-11-17 1994-02-01 Brown University Research Foundation Cell culture-containing tubular capsule produced by co-extrusion
US5824311A (en) 1987-11-30 1998-10-20 Trustees Of The University Of Pennsylvania Treatment of tumors with monoclonal antibodies against oncogene antigens
US5720937A (en) * 1988-01-12 1998-02-24 Genentech, Inc. In vivo tumor detection assay
WO1989006692A1 (fr) 1988-01-12 1989-07-27 Genentech, Inc. Procede de traitement de cellules tumorales par inhibition de la fonction receptrice du facteur de croissance
EP0435911B1 (fr) 1988-09-23 1996-03-13 Cetus Oncology Corporation Milieu de culture de cellules pour l'amelioration de la croissance des cellules, de la longivite de la culture et de l'expression du produit
GB8823869D0 (en) 1988-10-12 1988-11-16 Medical Res Council Production of antibodies
US5175384A (en) 1988-12-05 1992-12-29 Genpharm International Transgenic mice depleted in mature t-cells and methods for making transgenic mice
FR2646437B1 (fr) 1989-04-28 1991-08-30 Transgene Sa Nouvelles sequences d'adn, leur application en tant que sequence codant pour un peptide signal pour la secretion de proteines matures par des levures recombinantes, cassettes d'expression, levures transformees et procede de preparation de proteines correspondant
EP0474727B1 (fr) 1989-05-19 1997-07-23 Genentech, Inc. Domaine extracellulaire de her2
EP0402226A1 (fr) 1989-06-06 1990-12-12 Institut National De La Recherche Agronomique Vecteurs de transformation de la levure yarrowia
DE3920358A1 (de) 1989-06-22 1991-01-17 Behringwerke Ag Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung
ES2096590T3 (es) 1989-06-29 1997-03-16 Medarex Inc Reactivos biespecificos para la terapia del sida.
CA2066428C (fr) 1989-09-08 2000-11-28 Bert Vogelstein Modifications de la structure du gene recepteur du facteur de croissance epidermique dans les gliomes humains
EP0494135B1 (fr) 1989-09-29 1996-04-10 Oncogene Science, Inc. Protéine humaine "neu" p100 et son utilisation pour la détection de cellules prénéoplasiques ou néoplasiques chez l'homme
US5013556A (en) 1989-10-20 1991-05-07 Liposome Technology, Inc. Liposomes with enhanced circulation time
US5208020A (en) 1989-10-25 1993-05-04 Immunogen Inc. Cytotoxic agents comprising maytansinoids and their therapeutic use
CA2026147C (fr) * 1989-10-25 2006-02-07 Ravi J. Chari Agents cytotoxiques comprenant des maytansinoides et leur usage therapeutique
US5183884A (en) 1989-12-01 1993-02-02 United States Of America Dna segment encoding a gene for a receptor related to the epidermal growth factor receptor
US5229275A (en) 1990-04-26 1993-07-20 Akzo N.V. In-vitro method for producing antigen-specific human monoclonal antibodies
US5122469A (en) 1990-10-03 1992-06-16 Genentech, Inc. Method for culturing Chinese hamster ovary cells to improve production of recombinant proteins
US5571894A (en) 1991-02-05 1996-11-05 Ciba-Geigy Corporation Recombinant antibodies specific for a growth factor receptor
EP0586505A1 (fr) 1991-05-14 1994-03-16 Repligen Corporation Anticorps d'heteroconjugues pour le traitement des infections a l'hiv
IL101943A0 (en) 1991-05-24 1992-12-30 Genentech Inc Structure,production and use of heregulin
LU91067I2 (fr) 1991-06-14 2004-04-02 Genentech Inc Trastuzumab et ses variantes et dérivés immuno chimiques y compris les immotoxines
US5264586A (en) 1991-07-17 1993-11-23 The Scripps Research Institute Analogs of calicheamicin gamma1I, method of making and using the same
ES2136092T3 (es) 1991-09-23 1999-11-16 Medical Res Council Procedimientos para la produccion de anticuerpos humanizados.
US5587458A (en) 1991-10-07 1996-12-24 Aronex Pharmaceuticals, Inc. Anti-erbB-2 antibodies, combinations thereof, and therapeutic and diagnostic uses thereof
WO1993008829A1 (fr) 1991-11-04 1993-05-13 The Regents Of The University Of California Compositions induisant la destruction de cellules infectees par l'hiv
DE69233528T2 (de) 1991-11-25 2006-03-16 Enzon, Inc. Verfahren zur Herstellung von multivalenten antigenbindenden Proteinen
CA2372813A1 (fr) 1992-02-06 1993-08-19 L.L. Houston Proteine fixatrice biosynthetique pour marqueur du cancer
EP0626012B1 (fr) 1992-02-11 2003-07-09 Cell Genesys, Inc. Obtention d'homozygotes par ciblage de genes
US5573905A (en) 1992-03-30 1996-11-12 The Scripps Research Institute Encoded combinatorial chemical libraries
AU4025193A (en) 1992-04-08 1993-11-18 Cetus Oncology Corporation Humanized C-erbB-2 specific antibodies
ZA932522B (en) 1992-04-10 1993-12-20 Res Dev Foundation Immunotoxins directed against c-erbB-2(HER/neu) related surface antigens
WO1993024640A2 (fr) 1992-06-04 1993-12-09 The Regents Of The University Of California PROCEDES ET COMPOSITIONS UTILISES DANS UNE THERAPIE GENIQUE $i(IN VIVO)
EP0655924A4 (fr) 1992-06-30 1996-09-11 Oncologix Inc COMBINAISON D'ANTICORPS MONOCLONAUX ANTI-erbB-2 ET PROCEDE POUR SON UTILISATION.
DE69308573T2 (de) 1992-08-17 1997-08-07 Genentech Inc Bispezifische immunoadhesine
FR2697752B1 (fr) * 1992-11-10 1995-04-14 Rhone Poulenc Rorer Sa Compositions antitumorales contenant des dérivés du taxane.
JP3095175B2 (ja) 1992-11-13 2000-10-03 アイデック ファーマシューティカルズ コーポレイション Ｂ細胞リンパ腫の治療のためのヒトｂリンパ球限定分化抗原に対するキメラ抗体と放射能標識抗体の療法利用
CA2103323A1 (fr) 1992-11-24 1994-05-25 Gregory D. Plowman Tyrosine kinase du recepteur her4 humain
EP0616812B1 (fr) 1993-03-24 1999-11-03 Berlex Biosciences Combinaison d'agents anti-hormonause et molécules de liaison pour le traitement du cancer
WO1994022478A1 (fr) 1993-03-30 1994-10-13 The Trustees Of The University Of Pennsylvania PREVENTION DE TUMEURS AVEC DES ANTICORPS MONOCLONAUX DIRIGES CONTRE L'ONCOGENE $i(NEU)
WO1995014776A1 (fr) 1993-11-23 1995-06-01 Genentech, Inc. TYROSINE KINASES PROTEIQUES APPELEES Rse
ATE207366T1 (de) 1993-12-24 2001-11-15 Merck Patent Gmbh Immunokonjugate
US5773001A (en) 1994-06-03 1998-06-30 American Cyanamid Company Conjugates of methyltrithio antitumor agents and intermediates for their synthesis
US5910486A (en) 1994-09-06 1999-06-08 Uab Research Foundation Methods for modulating protein function in cells using, intracellular antibody homologues
US6214388B1 (en) 1994-11-09 2001-04-10 The Regents Of The University Of California Immunoliposomes that optimize internalization into target cells
AU4289496A (en) 1994-12-02 1996-06-19 Chiron Corporation Method of promoting an immune response with a bispecific antibody
US5731168A (en) 1995-03-01 1998-03-24 Genentech, Inc. Method for making heteromultimeric polypeptides
US5641870A (en) 1995-04-20 1997-06-24 Genentech, Inc. Low pH hydrophobic interaction chromatography for antibody purification
US5739277A (en) 1995-04-14 1998-04-14 Genentech Inc. Altered polypeptides with increased half-life
US5712374A (en) 1995-06-07 1998-01-27 American Cyanamid Company Method for the preparation of substantiallly monomeric calicheamicin derivative/carrier conjugates
EP0831880A4 (fr) 1995-06-07 2004-12-01 Imclone Systems Inc Anticorps et fragments d'anticorps inhibant la croissance des tumeurs
US5714586A (en) 1995-06-07 1998-02-03 American Cyanamid Company Methods for the preparation of monomeric calicheamicin derivative/carrier conjugates
US5837234A (en) 1995-06-07 1998-11-17 Cytotherapeutics, Inc. Bioartificial organ containing cells encapsulated in a permselective polyether suflfone membrane
DE69638269D1 (de) 1995-06-14 2010-11-18 Univ California Hochaffine humane antikörper gegen tumorantigene
PT2275119E (pt) 1995-07-27 2013-11-21 Genentech Inc Formulação de proteína liofilizada isotónica estável
US5783186A (en) 1995-12-05 1998-07-21 Amgen Inc. Antibody-induced apoptosis
US5922845A (en) 1996-07-11 1999-07-13 Medarex, Inc. Therapeutic multispecific compounds comprised of anti-Fcα receptor antibodies
AU727606B2 (en) * 1996-07-12 2000-12-14 Genentech Inc. Gamma-heregulin
EP0918746B1 (fr) * 1996-08-12 2003-04-09 Celgene Corporation Agents immunotherapiques et leur utilisation pour faire baisser les teneurs en cytokines
WO1998017797A1 (fr) * 1996-10-18 1998-04-30 Genentech, Inc. ANTICORPS ANTI-ErbB2
US5994071A (en) 1997-04-04 1999-11-30 Albany Medical College Assessment of prostate cancer
US6235883B1 (en) 1997-05-05 2001-05-22 Abgenix, Inc. Human monoclonal antibodies to epidermal growth factor receptor
WO1999019488A1 (fr) 1997-10-15 1999-04-22 Children's Medical Center Corporation Nouveaux recepteurs humains de l'egf et leur utilisation
ZA9811162B (en) * 1997-12-12 2000-06-07 Genentech Inc Treatment with anti-ERBB2 antibodies.
US6316462B1 (en) * 1999-04-09 2001-11-13 Schering Corporation Methods of inducing cancer cell death and tumor regression
JP5623681B2 (ja) * 1999-05-14 2014-11-12 ジェネンテック， インコーポレイテッド 抗−ＥｒｂＢ２抗体による治療
CN101518653B (zh) * 1999-06-25 2015-08-19 基因技术股份有限公司 使用抗ErbB抗体-类美坦素偶联物的治疗方法
DK1189634T3 (da) * 1999-06-25 2007-06-25 Genentech Inc Behandling af prostatacancer med anti-ErbB2-antistoffer
JP4780633B2 (ja) * 1999-06-25 2011-09-28 イムノゲン インコーポレーティッド 抗−ＥｒｂＢ抗体−メイタンシノイド複合体を用いた治療方法
KR20110008112A (ko) * 1999-08-27 2011-01-25 제넨테크, 인크. 항-ＥｒｂＢ2 항체 투여 치료 방법

Also Published As

Publication number Publication date
DK1189641T3 (da) 2009-11-16
JP2009142280A (ja) 2009-07-02
IL197359A0 (en) 2011-07-31
KR20020068264A (ko) 2002-08-27
EP2112167A2 (fr) 2009-10-28
DK1189641T5 (da) 2011-04-11
CH694589A5 (de) 2005-04-15
MXPA01013458A (es) 2002-07-30
AU2005242195A1 (en) 2006-01-12
HUP0201695A2 (en) 2002-09-28
ZA200109786B (en) 2002-11-28
TR200103756T2 (tr) 2002-06-21
JP2003503366A (ja) 2003-01-28
IL146954A (en) 2009-09-22
WO2001000245A3 (fr) 2001-10-25
GEP20104998B (en) 2010-06-10
CY2013010I1 (el) 2015-08-05
BR0012198A (pt) 2002-04-02
RU2005132788A (ru) 2007-04-27
BR122014028365B8 (pt) 2021-07-06
CA2376596C (fr) 2009-10-06
ATE437655T1 (de) 2009-08-15
NO20091792L (no) 2002-02-25
AU2005242195B2 (en) 2009-06-11
LU92164I2 (fr) 2013-05-07
KR20070094993A (ko) 2007-09-27
RU2430739C9 (ru) 2015-12-20
CN101518653A (zh) 2009-09-02
HU226742B1 (en) 2009-08-28
CN101518653B (zh) 2015-08-19
EP2112167A3 (fr) 2010-12-22
AT500848B1 (de) 2008-01-15
WO2001000245A2 (fr) 2001-01-04
AU5763200A (en) 2001-01-31
IL146954A0 (en) 2002-08-14
PT1189641E (pt) 2009-11-04
AT500848A1 (de) 2006-04-15
BRPI0012198B1 (pt) 2016-12-20
GB2368796B (en) 2004-08-04
SI2283867T1 (sl) 2014-07-31
CN100340575C (zh) 2007-10-03
AU784045B2 (en) 2006-01-19
CY1109525T1 (el) 2014-08-13
ZA200110263B (en) 2003-02-26
ES2329437T3 (es) 2009-11-26
EP1189641B1 (fr) 2009-07-29
CY2013010I2 (el) 2015-08-05
FR13C0016I2 (fr) 2014-05-16
CZ299702B6 (cs) 2008-10-22
SI2283866T1 (sl) 2015-07-31
SI1189641T1 (sl) 2009-12-31
FR13C0016I1 (fr) 2013-04-12
HUP0201695A3 (en) 2005-06-28
RU2430739C2 (ru) 2011-10-10
PL204629B1 (pl) 2010-01-29
AR024464A1 (es) 2002-10-02
NO20016329L (no) 2002-02-25
NO328377B1 (no) 2010-02-08
DE60042648D1 (de) 2009-09-10
RU2270029C2 (ru) 2006-02-20
NO336040B1 (no) 2015-04-27
NO2013005I1 (no) 2013-04-02
CA2376596A1 (fr) 2001-01-04
KR100850389B1 (ko) 2008-08-04
NZ516830A (en) 2004-07-30
CN101121021B (zh) 2011-12-07
KR100797308B1 (ko) 2008-01-23
BR122014028365B1 (pt) 2020-01-28
GB0200506D0 (en) 2002-02-27
CZ20014596A3 (cs) 2003-02-12
PL203326B1 (pl) 2009-09-30
BRPI0012198B8 (pt) 2021-05-25
JP4283474B2 (ja) 2009-06-24
GB2368796A (en) 2002-05-15
NO2013005I2 (no) 2013-03-12
PL352321A1 (en) 2003-08-11
HK1044888A1 (en) 2002-11-08
CA2727172A1 (fr) 2001-01-04
NZ531426A (en) 2005-10-28
CN101121021A (zh) 2008-02-13
NO20016329D0 (no) 2001-12-21
EP1189641A2 (fr) 2002-03-27
CN101121750A (zh) 2008-02-13
CN1370082A (zh) 2002-09-18
DE10084743T1 (de) 2002-08-14

Similar Documents

Publication Publication Date Title
BE2018C020I2 (fr)
BE2015C057I2 (fr)
BE2016C007I2 (fr)
BE2015C018I2 (fr)
BE2014C017I2 (fr)
BE2013C051I2 (fr)
FR13C0016I1 (fr)
BE2013C015I2 (fr)
BE2013C001I2 (fr)
BE2012C036I2 (fr)
BE2011C004I2 (fr)
BE2010C011I2 (fr)
BE2008C046I2 (fr)
BE1025464I2 (fr)
JP2002518883A5 (fr)
JP2002523809A5 (fr)
JP2002518715A5 (fr)
JP2002520169A5 (fr)
BE2008C047I2 (fr)
JP2002511615A5 (fr)
BRPI0001672A2 (fr)
JP2002506670A5 (fr)
JP2002502048A5 (fr)
BRPI0001542A2 (fr)
JP2002521991A5 (fr)