ATE241602T1 - Sulfonamide inhibitore von hiv-aspartyl protease - Google Patents

Sulfonamide inhibitore von hiv-aspartyl protease

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Publication number
ATE241602T1
ATE241602T1 AT98113921T AT98113921T ATE241602T1 AT E241602 T1 ATE241602 T1 AT E241602T1 AT 98113921 T AT98113921 T AT 98113921T AT 98113921 T AT98113921 T AT 98113921T AT E241602 T1 ATE241602 T1 AT E241602T1
Authority
AT
Austria
Prior art keywords
inhibiters
sulfonamide
hiv
aspartyl protease
aspartyl
Prior art date
Application number
AT98113921T
Other languages
German (de)
English (en)
Inventor
Roger D Tung
Mark A Murcko
Govinda Rao Bhisetti
Original Assignee
Vertex Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vertex Pharma filed Critical Vertex Pharma
Application granted granted Critical
Publication of ATE241602T1 publication Critical patent/ATE241602T1/de

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    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
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    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
    • C07C311/12—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings
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    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
    • C07C311/18—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical substituted by nitrogen atoms, not being part of nitro or nitroso groups
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    • C07C311/22—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
    • C07C311/29—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
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    • C07C311/38—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton
    • C07C311/39—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
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AT98113921T 1992-09-08 1993-09-07 Sulfonamide inhibitore von hiv-aspartyl protease ATE241602T1 (de)

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US6372778B1 (en) 2002-04-16
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SG43862A1 (en) 1997-11-14
ATE178598T1 (de) 1999-04-15
JPH08501299A (ja) 1996-02-13
DE10199024I1 (de) 2001-07-12
DE69333012D1 (de) 2003-07-03
GR3030719T3 (en) 1999-11-30
ES2131589T3 (es) 1999-08-01
US20080293727A1 (en) 2008-11-27
AU4852093A (en) 1994-03-29
HU9500685D0 (en) 1995-04-28
DE69324369T2 (de) 1999-08-26
DK0659181T3 (da) 1999-10-18
RU2135496C1 (ru) 1999-08-27
EP0659181B1 (en) 1999-04-07
TW254927B (cg-RX-API-DMAC7.html) 1995-08-21
PT885887E (pt) 2003-10-31
KR100262056B1 (ko) 2000-07-15
PL307858A1 (en) 1995-06-26
US7608632B2 (en) 2009-10-27
US20030069222A1 (en) 2003-04-10
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