AT501681B1 - Feste orale pharmazeutische zusammensetzung enthaltend 2-amino-1,3-propandiole - Google Patents

Feste orale pharmazeutische zusammensetzung enthaltend 2-amino-1,3-propandiole Download PDF

Info

Publication number
AT501681B1
AT501681B1 ATA606/2004A AT6062004A AT501681B1 AT 501681 B1 AT501681 B1 AT 501681B1 AT 6062004 A AT6062004 A AT 6062004A AT 501681 B1 AT501681 B1 AT 501681B1
Authority
AT
Austria
Prior art keywords
composition
defined above
treatment
prevention
disease
Prior art date
Application number
ATA606/2004A
Other languages
German (de)
English (en)
Other versions
AT501681A1 (de
Original Assignee
Novartis Ag
Mitsubishi Pharma Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=32326722&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AT501681(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag, Mitsubishi Pharma Corp filed Critical Novartis Ag
Publication of AT501681A1 publication Critical patent/AT501681A1/de
Priority to AT0074408A priority Critical patent/AT504853A2/de
Application granted granted Critical
Publication of AT501681B1 publication Critical patent/AT501681B1/de

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/145Amines having sulfur, e.g. thiurams (>N—C(S)—S—C(S)—N< and >N—C(S)—S—S—C(S)—N<), Sulfinylamines (—N=SO), Sulfonylamines (—N=SO2)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/135Amines having aromatic rings, e.g. ketamine, nortriptyline
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/135Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/135Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/138Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2013Organic compounds, e.g. phospholipids, fats
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2013Organic compounds, e.g. phospholipids, fats
    • A61K9/2018Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2022Organic macromolecular compounds
    • A61K9/205Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841Filling excipients; Inactive ingredients
    • A61K9/4858Organic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841Filling excipients; Inactive ingredients
    • A61K9/4866Organic macromolecular compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Emergency Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Psychiatry (AREA)
  • Cardiology (AREA)
  • Rheumatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Transplantation (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Virology (AREA)
  • Surgery (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
ATA606/2004A 2003-04-08 2004-04-06 Feste orale pharmazeutische zusammensetzung enthaltend 2-amino-1,3-propandiole AT501681B1 (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AT0074408A AT504853A2 (de) 2003-04-08 2008-05-08 Organische verbindungen

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US46121503P 2003-04-08 2003-04-08

Publications (2)

Publication Number Publication Date
AT501681A1 AT501681A1 (de) 2006-10-15
AT501681B1 true AT501681B1 (de) 2012-04-15

Family

ID=32326722

Family Applications (3)

Application Number Title Priority Date Filing Date
ATA606/2004A AT501681B1 (de) 2003-04-08 2004-04-06 Feste orale pharmazeutische zusammensetzung enthaltend 2-amino-1,3-propandiole
AT04725895T ATE414508T1 (de) 2003-04-08 2004-04-06 Feste pharmazeutische darreichungsformen mit einem s1p rezeptoragonisten und einem zuckeralkohol
AT0074408A AT504853A2 (de) 2003-04-08 2008-05-08 Organische verbindungen

Family Applications After (2)

Application Number Title Priority Date Filing Date
AT04725895T ATE414508T1 (de) 2003-04-08 2004-04-06 Feste pharmazeutische darreichungsformen mit einem s1p rezeptoragonisten und einem zuckeralkohol
AT0074408A AT504853A2 (de) 2003-04-08 2008-05-08 Organische verbindungen

Country Status (41)

Country Link
US (11) US20060275357A1 (cg-RX-API-DMAC7.html)
EP (5) EP2769713A1 (cg-RX-API-DMAC7.html)
JP (3) JP5495467B2 (cg-RX-API-DMAC7.html)
KR (3) KR20110005320A (cg-RX-API-DMAC7.html)
CN (2) CN1767819B (cg-RX-API-DMAC7.html)
AR (3) AR043987A1 (cg-RX-API-DMAC7.html)
AT (3) AT501681B1 (cg-RX-API-DMAC7.html)
AU (1) AU2004228929B2 (cg-RX-API-DMAC7.html)
BE (2) BE1015972A5 (cg-RX-API-DMAC7.html)
BR (1) BRPI0409250B8 (cg-RX-API-DMAC7.html)
CA (2) CA2707750A1 (cg-RX-API-DMAC7.html)
CL (2) CL2004000745A1 (cg-RX-API-DMAC7.html)
CY (3) CY1110260T1 (cg-RX-API-DMAC7.html)
DE (4) DE122011100047I1 (cg-RX-API-DMAC7.html)
DK (2) DK1613288T3 (cg-RX-API-DMAC7.html)
EC (1) ECSP056090A (cg-RX-API-DMAC7.html)
ES (3) ES2228282B1 (cg-RX-API-DMAC7.html)
FR (2) FR2854073B1 (cg-RX-API-DMAC7.html)
GB (1) GB2400318B (cg-RX-API-DMAC7.html)
GR (1) GR1005052B (cg-RX-API-DMAC7.html)
HR (3) HRP20050886B1 (cg-RX-API-DMAC7.html)
HU (2) HUE028247T2 (cg-RX-API-DMAC7.html)
IL (3) IL170888A (cg-RX-API-DMAC7.html)
IS (2) IS2682B (cg-RX-API-DMAC7.html)
IT (1) ITMI20040682A1 (cg-RX-API-DMAC7.html)
LU (1) LU91867I2 (cg-RX-API-DMAC7.html)
MA (1) MA27729A1 (cg-RX-API-DMAC7.html)
MX (1) MXPA05010860A (cg-RX-API-DMAC7.html)
MY (1) MY141249A (cg-RX-API-DMAC7.html)
NO (4) NO329332B1 (cg-RX-API-DMAC7.html)
NZ (3) NZ542622A (cg-RX-API-DMAC7.html)
PE (5) PE20050396A1 (cg-RX-API-DMAC7.html)
PL (2) PL2316431T3 (cg-RX-API-DMAC7.html)
PT (1) PT1613288E (cg-RX-API-DMAC7.html)
RU (5) RU2358716C2 (cg-RX-API-DMAC7.html)
SG (1) SG175449A1 (cg-RX-API-DMAC7.html)
SI (2) SI2316431T1 (cg-RX-API-DMAC7.html)
TN (1) TNSN05256A1 (cg-RX-API-DMAC7.html)
TW (1) TWI332847B (cg-RX-API-DMAC7.html)
WO (1) WO2004089341A1 (cg-RX-API-DMAC7.html)
ZA (1) ZA200507394B (cg-RX-API-DMAC7.html)

Families Citing this family (72)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2007001236A (es) * 2004-07-30 2007-03-23 Novartis Ag Formulaciones de compuestos de 2-amino-1, 3-propanodiol.
CN1891212B (zh) * 2005-07-07 2010-10-13 马启明 一种口服制剂及其制备方法
PT2295049E (pt) * 2005-09-09 2015-03-02 Novartis Ag Tratamento de doenças auto-imunes
WO2007056464A1 (en) 2005-11-09 2007-05-18 Proteolix, Inc. Compounds for enzyme inhibition
TWI389683B (zh) * 2006-02-06 2013-03-21 Kyorin Seiyaku Kk A therapeutic agent for an inflammatory bowel disease or an inflammatory bowel disease treatment using a 2-amino-1,3-propanediol derivative as an active ingredient
AU2007261345B2 (en) 2006-06-19 2012-02-23 Onyx Therapeutics, Inc. Peptide epoxyketones for proteasome inhibition
GB0612721D0 (en) 2006-06-27 2006-08-09 Novartis Ag Organic compounds
EP1923058A1 (en) * 2006-09-26 2008-05-21 Novartis AG Coated pharmaceutical composition comprising an S1P agonist or modulator
MX2009002993A (es) * 2006-09-26 2009-04-01 Novartis Ag Composiciones farmaceuticas que comprenden un modulador de s1p.
AU2011235934A1 (en) * 2006-09-26 2011-11-03 Novartis Ag Pharmaceutical compositions comprising an S1P modulator
EP1923055A1 (en) * 2006-09-26 2008-05-21 Novartis AG Freeze-dried pharmaceutical composition comprising an S1P agonist or modulator
EP1905434A1 (en) * 2006-09-26 2008-04-02 Novartis AG Organic compounds comprising an S1P receptor agonist and their therapeutic use
EP1923054A1 (en) * 2006-09-26 2008-05-21 Novartis AG Fast disintegrating pharmaceutical composition comprising an S1P agonist or modulator
WO2008124210A1 (en) * 2007-02-14 2008-10-16 Emory University Methods and compositions for treating or preventing infection using leukocyte sequestration agents
WO2008129846A1 (ja) 2007-03-29 2008-10-30 Daiichi Sankyo Company, Limited 医薬組成物
NZ598436A (en) 2007-10-04 2014-03-28 Onyx Therapeutics Inc Crystalline peptide epoxy ketone protease inhibitors and the synthesis of amino acid keto-epoxides
AU2012216630B2 (en) * 2007-10-12 2015-01-22 Novartis Ag Compositions comprising sphingosine 1 phosphate (S1P) receptor modulators
HUE027696T2 (en) 2007-10-12 2016-10-28 Novartis Ag Preparations containing sphingosine-1-phosphate (S1P) receptor modulators
JP5534645B2 (ja) * 2008-01-11 2014-07-02 日医工株式会社 無包装状態において安定性に優れた塩酸サルポグレラート含有経口投与製剤
JP5452237B2 (ja) 2008-02-07 2014-03-26 杏林製薬株式会社 アミノアルコール誘導体を有効成分とする炎症性腸疾患の治療剤又は予防剤
RU2519660C2 (ru) 2008-03-17 2014-06-20 Актелион Фармасьютиклз Лтд Режим дозировки селективного агониста рецептора s1p1
BRPI0914164B1 (pt) * 2008-06-20 2019-04-30 Merck Patent Gmbh Comistura para produção de comprimidos de desintegração rápida em um processo de formação de comprimido direto, seus usos, e formulações de comprimido
EP2303250A1 (en) 2008-06-20 2011-04-06 Novartis AG Paediatric compositions for treating1 multiple sclerosis
SI2334202T1 (sl) * 2008-09-04 2012-04-30 Cargill Inc Tabletiranje eritritola
MX368109B (es) 2008-10-21 2019-09-18 Onyx Therapeutics Inc Terapia de combinacion con epoxicetonas peptidicas.
AU2013100531B4 (en) * 2008-11-11 2013-11-28 Novartis Ag Crystalline forms of fingolimod HCL
CN102209705A (zh) * 2008-11-11 2011-10-05 诺瓦提斯公司 芬戈莫德盐酸盐的结晶形式
JP2012508215A (ja) 2008-11-11 2012-04-05 ノバルティス アーゲー 有機化合物
CN102256984B (zh) 2008-12-17 2014-09-03 第一三共株式会社 制备二胺衍生物的方法
WO2010082531A1 (ja) 2009-01-13 2010-07-22 第一三共株式会社 活性化血液凝固因子阻害剤
CN102348688B (zh) 2009-03-10 2014-07-09 第一三共株式会社 用于制备二胺衍生物的方法
CN102348680B (zh) 2009-03-13 2014-11-05 第一三共株式会社 用于制备光学活性二胺衍生物的方法
TWI504598B (zh) 2009-03-20 2015-10-21 Onyx Therapeutics Inc 結晶性三肽環氧酮蛋白酶抑制劑
EP2444087B1 (en) * 2009-06-18 2016-09-07 Daiichi Sankyo Company, Limited Pharmaceutical composition having improved solubility
US9675566B2 (en) 2009-07-16 2017-06-13 Pathologica Llc Method of treatment with anti-inflammatory and analgesic compounds which are GI-, renal-, and platelet-sparing
WO2011060179A1 (en) 2009-11-13 2011-05-19 Onyx Therapeutics, Inc Use of peptide epoxyketones for metastasis suppression
AU2011223795B2 (en) 2010-03-01 2015-11-05 Onyx Therapeutics, Inc. Compounds for immunoproteasome inhibition
WO2011115067A1 (ja) 2010-03-19 2011-09-22 第一三共株式会社 抗凝固剤の溶出改善方法
WO2011115066A1 (ja) 2010-03-19 2011-09-22 第一三共株式会社 ジアミン誘導体の結晶およびその製造方法
EA201291095A1 (ru) * 2010-04-22 2013-04-30 Рациофарм Гмбх Способ получения пероральной лекарственной формы, содержащей финголимод
WO2012002538A1 (ja) 2010-07-02 2012-01-05 第一三共株式会社 光学活性ジアミン誘導体の塩の製造方法
US9266816B2 (en) 2010-11-25 2016-02-23 Shilpa Medicare Limited Fingolimod polymorphs and their processes
KR101951966B1 (ko) 2011-01-07 2019-02-25 노파르티스 아게 면역억제제 제제
WO2012100043A2 (en) 2011-01-19 2012-07-26 Pathlogica LLC Controlled release oral pharmaceutical dosage forms comprising mgbg
AR085749A1 (es) * 2011-04-01 2013-10-23 Novartis Ag Formulaciones
WO2013019872A1 (en) 2011-08-01 2013-02-07 Teva Pharmaceutical Industries Ltd. Process for preparing pharmaceutical compositions comprising fingolimod
ES2673182T3 (es) 2011-08-10 2018-06-20 Daiichi Sankyo Company, Limited Composición farmacéutica que contiene un derivado de diamina
WO2013091704A1 (en) 2011-12-22 2013-06-27 Synthon Bv Pharmaceutical composition comprising fingolimod
RU2482842C1 (ru) * 2012-04-26 2013-05-27 Открытое акционерное общество "Новосибхимфарм" Фармацевтическая композиция агониста рецептора s1p для лечения демиелинизационных заболеваний (варианты) и способ ее получения
RU2506949C1 (ru) * 2012-06-13 2014-02-20 Открытое акционерное общество "Новосибхимфарм" Фармацевтическая композиция агониста рецептора s1p для лечения демиелинизационных заболеваний
WO2014011695A2 (en) 2012-07-09 2014-01-16 Onyx Therapeutics, Inc. Prodrugs of peptide epoxy ketone protease inhibitors
RU2496486C1 (ru) 2012-07-11 2013-10-27 Александр Васильевич Иващенко Фармацевтическая композиция с улучшенной сыпучестью, лекарственное средство, способ получения и применение
WO2014110154A1 (en) * 2013-01-08 2014-07-17 Pathologica Llc Methods and comp0stions for treatment of demyelinating diseases
WO2014141298A2 (en) * 2013-03-11 2014-09-18 Astron Research Limited Stable pharmaceutical composition of fingolimod
WO2014175287A1 (ja) * 2013-04-26 2014-10-30 国立大学法人 京都大学 脳動脈瘤の形成および/または増大の抑制若しくは縮小用医薬組成物
WO2013190151A1 (en) * 2013-05-13 2013-12-27 Synthon B.V. Pharmaceutical composition comprising fingolimod
MX2016001422A (es) * 2013-07-29 2016-10-05 Aizant Drug Res Solutions Pvt Ltd Composicion farmaceutica de fingolimod.
RU2530626C1 (ru) * 2013-10-21 2014-10-10 Ооо "Валента-Интеллект" Фармацевтическая композиция агониста рецептора s1p для лечения демиелинизационных заболеваний
WO2016026461A1 (en) * 2014-08-22 2016-02-25 Sunshine Lake Pharma Co., Ltd. Solid composition of fingolimod and preparation thereof
WO2016042493A1 (en) * 2014-09-19 2016-03-24 Aizant Drug Research Pvt. Ltd Pharmaceutical compositions of fingolimod
US9925138B2 (en) 2015-01-20 2018-03-27 Handa Pharmaceuticals, Llc Stable solid fingolimod dosage forms
WO2016118515A1 (en) * 2015-01-20 2016-07-28 Handa Pharmaceuticals, Llc Stable solid fingolimod dosage forms
WO2016135644A1 (en) 2015-02-26 2016-09-01 Novartis Ag Treatment of autoimmune disease in a patient receiving additionally a beta-blocker
RU2577230C1 (ru) * 2015-04-09 2016-03-10 Общество с ограниченной ответственностью "Лонг Шенг Фарма Рус" Способ получения капсул финголимода гидрохлорида
US9690975B2 (en) * 2015-05-28 2017-06-27 Axogen Corporation Quantitative structural assay of a nerve graft
US11434200B2 (en) 2017-03-09 2022-09-06 Novartis Ag Solid forms comprising an oxime ether compound and a coformer, compositions and methods of use thereof
WO2018178744A1 (en) 2017-03-29 2018-10-04 Deva Holding Anonim Sirketi Stable formulations of fingolimod
GR1009654B (el) 2018-08-31 2019-11-18 Φαρματεν Α.Β.Ε.Ε. Φαρμακευτικο σκευασμα που περιλαμβανει εναν ανοσοτροποποιητικο παραγοντα και μεθοδος για την παρασκευη αυτου
DE102018217334A1 (de) 2018-10-10 2020-04-16 Harbins Ruhr Bioscience, Inc. Sphingoid-Base und/oder Wirkstoff zur Verwendung bei der Prophylaxe und/oder Therapie einer viralen Infektion und/oder viralen Infektionskrankheit oder der Desinfektion, Nahrungsmittel/Nahrungsergänzungsmittel, Futtermittel/Futterergänzungsmittel und Pflanzenschutzmittel
JP7503420B2 (ja) * 2020-05-18 2024-06-20 東和薬品株式会社 フィンゴリモドを含む医薬組成物とその製造方法及び安定化方法
WO2022015348A1 (en) 2020-07-16 2022-01-20 Harbins Ruhr Bioscience, Inc. Sphingoid compounds for use in prophylaxis and/or therapy of coronaviridae infection
MX2023008907A (es) * 2021-01-28 2023-08-09 Priothera Sas Metodos de tratamiento con moduladores del receptor de esfingosina-1-fosfato (s1p).

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0627406A1 (en) * 1992-10-21 1994-12-07 Yoshitomi Pharmaceutical Industries, Ltd. 2-amino-1,3-propanediol compound and immunosuppressant
EP0990440A1 (en) * 1997-02-27 2000-04-05 Yoshitomi Pharmaceutical Industries, Ltd. Drug composition
EP1002792A1 (en) * 1997-04-04 2000-05-24 Yoshitomi Pharmaceutical Industries, Ltd. 2-aminopropane-1,3-diol compounds, medicinal use thereof, and intermediates in synthesizing the same
EP1050301A1 (en) * 1998-01-19 2000-11-08 Yoshitomi Pharmaceutical Industries, Ltd. Medicinal compositions
EP1201236A1 (en) * 1999-06-30 2002-05-02 Mitsubishi Pharma Corporation Medicinal compositions for preventing or treating viral myocarditis
JP2002241272A (ja) * 1996-07-18 2002-08-28 Mitsubishi Pharma Corp 医薬処方組成物

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL7607683A (nl) * 1976-07-12 1978-01-16 Akzo Nv Werkwijze ter bereiding van nieuwe peptiden en peptide-derivaten en de toepassing hiervan.
US4110332A (en) * 1977-05-05 1978-08-29 Chevron Research Company 1-Triorganostannyl-3-organothio-4-substituted-1,2,4-delta2 -triazolidin-5-ones
US4559153A (en) 1983-10-25 1985-12-17 Phillips Petroleum Company Metal working lubricant
US5112616A (en) * 1988-11-30 1992-05-12 Schering Corporation Fast dissolving buccal tablet
JP2841857B2 (ja) * 1990-11-29 1998-12-24 田辺製薬株式会社 長期間安定な経口用医薬製剤
JP3870419B2 (ja) 1994-08-22 2007-01-17 三菱ウェルファーマ株式会社 ベンゼン化合物およびその医薬としての用途
PT812588E (pt) 1995-12-28 2005-01-31 Mitsubishi Pharma Corp Composicao farmaceutica externa para administracao topica contendo 2-amino-2-(2-(4-octilfenil)-etil)-propano-1,3-diol para o tratamento de doencas provocadas por uma afeccao imunitaria
US6476004B1 (en) * 1996-07-18 2002-11-05 Mitsubishi Pharma Corporation Pharmaceutical composition
GB9624038D0 (en) 1996-11-19 1997-01-08 Sandoz Ltd Organic compounds
JPH1180026A (ja) 1997-09-02 1999-03-23 Yoshitomi Pharmaceut Ind Ltd 新規免疫抑制剤、その使用方法およびその同定方法
JP3545595B2 (ja) 1998-04-01 2004-07-21 花王株式会社 スフィンゴ糖脂質の製造法
KR20020027463A (ko) * 1999-07-12 2002-04-13 우에노 도시오 스핀고신-1-인산 수용체 아고니스트 또는스핀고신-1-인산을 유효 성분으로서 함유하는 선유화 억제제
CN1328387C (zh) 2000-07-13 2007-07-25 三共株式会社 氨基醇衍生物
AU8533101A (en) * 2000-08-31 2002-03-13 Merck & Co Inc Phosphate derivatives as immunoregulatory agents
US6953332B1 (en) 2000-11-28 2005-10-11 St. Jude Medical, Inc. Mandrel for use in forming valved prostheses having polymer leaflets by dip coating
IL157773A0 (en) 2001-03-26 2004-03-28 Novartis Ag 2-amino-propanol derivatives
US7521192B2 (en) 2001-04-18 2009-04-21 Rigel Pharmaceuticals, Inc. EDG: modulators of lymphocyte activation and migration
JP2002316985A (ja) 2001-04-20 2002-10-31 Sankyo Co Ltd ベンゾチオフェン誘導体
WO2003020313A1 (en) 2001-09-04 2003-03-13 Ono Pharmaceutical Co., Ltd. Remedies for respiratory diseases comprising sphingosine-1-phosphate receptor controller
CA2460640C (en) * 2001-09-27 2011-03-29 Kyorin Pharmaceutical Co., Ltd. Diaryl ether derivatives, salts thereof and immunosuppressive agents using the same
WO2003029205A1 (fr) 2001-09-27 2003-04-10 Kyorin Pharmaceutical Co., Ltd. Derive de sulfure de diaryle, son sel d'addition et immunosuppresseur
JP4709488B2 (ja) 2002-01-18 2011-06-22 メルク・シャープ・エンド・ドーム・コーポレイション Edg受容体作動薬としてのN−(ベンジル)アミノアルキルカルボン酸化合物、ホスフィン酸化合物、ホスホン酸化合物およびテトラゾール類
CA2473740A1 (en) 2002-01-18 2003-07-31 David Solow-Cordero Methods of treating conditions associated with an edg receptor
DE60329073D1 (de) 2002-01-18 2009-10-15 Merck & Co Inc Edg-rezeptoragonisten
AU2003216054B2 (en) 2002-01-18 2007-01-04 Merck & Co., Inc. Selective S1P1/Edg1 receptor agonists
CN101905023B (zh) * 2004-07-16 2012-07-11 杏林制药株式会社 有效的医药使用方法及与副作用发生的防御相关的方法

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0627406A1 (en) * 1992-10-21 1994-12-07 Yoshitomi Pharmaceutical Industries, Ltd. 2-amino-1,3-propanediol compound and immunosuppressant
JP2002241272A (ja) * 1996-07-18 2002-08-28 Mitsubishi Pharma Corp 医薬処方組成物
EP0990440A1 (en) * 1997-02-27 2000-04-05 Yoshitomi Pharmaceutical Industries, Ltd. Drug composition
EP1002792A1 (en) * 1997-04-04 2000-05-24 Yoshitomi Pharmaceutical Industries, Ltd. 2-aminopropane-1,3-diol compounds, medicinal use thereof, and intermediates in synthesizing the same
EP1050301A1 (en) * 1998-01-19 2000-11-08 Yoshitomi Pharmaceutical Industries, Ltd. Medicinal compositions
EP1201236A1 (en) * 1999-06-30 2002-05-02 Mitsubishi Pharma Corporation Medicinal compositions for preventing or treating viral myocarditis

Also Published As

Publication number Publication date
PE20150676A1 (es) 2015-05-17
IS8114A (is) 2005-11-01
JP2004307506A (ja) 2004-11-04
AU2004228929A1 (en) 2004-10-21
US20080311188A1 (en) 2008-12-18
GB2400318A (en) 2004-10-13
NO335120B1 (no) 2014-09-22
NO334116B1 (no) 2013-12-16
RU2012148593A (ru) 2014-05-20
LU91867I9 (cg-RX-API-DMAC7.html) 2019-01-03
BRPI0409250B1 (pt) 2017-07-11
US20190175527A1 (en) 2019-06-13
GB2400318B (en) 2005-08-10
FR11C0036I2 (fr) 2023-12-29
AT504853A2 (de) 2008-08-15
PT1613288E (pt) 2009-02-25
AR078781A2 (es) 2011-11-30
FR11C0036I1 (fr) 2011-10-14
MA27729A1 (fr) 2006-01-02
US8324283B2 (en) 2012-12-04
US20220031609A1 (en) 2022-02-03
SG175449A1 (en) 2011-11-28
NO2011016I2 (no) 2012-08-27
PE20050396A1 (es) 2005-07-05
CY2011013I2 (el) 2014-04-09
ITMI20040682A1 (it) 2004-07-06
EP1613288B1 (en) 2008-11-19
NO20055231D0 (no) 2005-11-07
NO329332B1 (no) 2010-09-27
NO20100250L (no) 2006-01-09
NZ586280A (en) 2011-12-22
MXPA05010860A (es) 2006-05-25
ZA200507394B (en) 2007-03-28
HRP20100601A2 (hr) 2011-03-31
CN101797241B (zh) 2013-03-27
EP2316431A1 (en) 2011-05-04
HK1071685A1 (en) 2005-07-29
TW200503784A (en) 2005-02-01
IL170888A (en) 2010-06-16
HRP20050886B1 (en) 2011-01-31
DK2316431T3 (en) 2016-01-11
HUE028247T2 (en) 2016-12-28
CN1767819B (zh) 2010-07-28
FR2854073A1 (fr) 2004-10-29
HRP20050886A2 (en) 2006-11-30
PE20131352A1 (es) 2013-11-14
RU2009105403A (ru) 2010-08-27
EP2319502A1 (en) 2011-05-11
CY1110260T1 (el) 2014-04-09
IS2682B (is) 2010-10-15
DE102004016947A1 (de) 2004-10-21
US20090203798A1 (en) 2009-08-13
US20130108675A1 (en) 2013-05-02
US20140011885A1 (en) 2014-01-09
ECSP056090A (es) 2006-03-01
US20110105620A1 (en) 2011-05-05
EP2008650A3 (en) 2011-04-27
KR20120101148A (ko) 2012-09-12
IS8885A (is) 2010-02-25
HUS1100016I1 (hu) 2016-08-29
HK1091114A1 (en) 2007-01-12
US20140255497A1 (en) 2014-09-11
IE20040246A1 (en) 2004-12-15
EP2316431B1 (en) 2015-09-30
AT501681A1 (de) 2006-10-15
PE20090743A1 (es) 2009-07-17
CN101797241A (zh) 2010-08-11
PE20130200A1 (es) 2013-03-09
NZ592339A (en) 2012-09-28
US20200237690A1 (en) 2020-07-30
TWI332847B (en) 2010-11-11
BE2011C030I2 (cg-RX-API-DMAC7.html) 2023-03-07
AU2004228929B2 (en) 2008-02-07
EP2008650A2 (en) 2008-12-31
KR101367574B1 (ko) 2014-02-25
SI1613288T1 (sl) 2009-04-30
PL1613288T3 (pl) 2009-07-31
AR078782A2 (es) 2011-11-30
SI2316431T1 (sl) 2016-04-29
US20170290787A1 (en) 2017-10-12
AR043987A1 (es) 2005-08-17
JP5495467B2 (ja) 2014-05-21
US20060275357A1 (en) 2006-12-07
CA2707750A1 (en) 2004-10-21
NO20131287L (no) 2006-01-09
KR20110005320A (ko) 2011-01-17
JP2011006461A (ja) 2011-01-13
HK1155647A1 (en) 2012-05-25
EP1613288A1 (en) 2006-01-11
ES2320767T3 (es) 2009-05-28
IL197578A0 (en) 2011-07-31
RU2475237C2 (ru) 2013-02-20
DE122011100047I1 (de) 2011-12-15
RU2010146697A (ru) 2012-05-27
FR2854073B1 (fr) 2008-03-14
ES2228282B1 (es) 2006-02-16
EP2769713A1 (en) 2014-08-27
CN1767819A (zh) 2006-05-03
ES2228282A1 (es) 2005-04-01
MY141249A (en) 2010-03-31
RU2005134173A (ru) 2006-09-10
NZ542622A (en) 2009-01-31
HRP20100600A2 (hr) 2011-03-31
IL242037A0 (en) 2015-11-30
GR20040100121A (el) 2004-12-17
TNSN05256A1 (en) 2007-07-10
CL2004000745A1 (es) 2005-02-11
LU91867I2 (fr) 2011-11-08
ES2556947T3 (es) 2016-01-21
DK1613288T3 (da) 2009-03-23
RU2475236C2 (ru) 2013-02-20
HRP20100601B1 (hr) 2016-12-02
IL197578A (en) 2015-10-29
RU2358716C2 (ru) 2009-06-20
GR1005052B (el) 2005-11-30
KR20050121712A (ko) 2005-12-27
JP2013177404A (ja) 2013-09-09
BRPI0409250B8 (pt) 2022-01-18
CA2521325A1 (en) 2004-10-21
CY1117071T1 (el) 2017-04-05
DE602004017847D1 (de) 2009-01-02
BRPI0409250A (pt) 2006-03-28
CY2011013I1 (el) 2014-04-09
RU2010147000A (ru) 2012-08-10
GB0407819D0 (en) 2004-05-12
WO2004089341A1 (en) 2004-10-21
DE202004021680U1 (de) 2010-04-22
ATE414508T1 (de) 2008-12-15
NO20055231L (no) 2006-01-09
PL2316431T3 (pl) 2016-09-30
BE1015972A5 (fr) 2005-12-06
CL2011000450A1 (es) 2011-11-25
JP5543298B2 (ja) 2014-07-09
CA2521325C (en) 2010-09-14
NO2011016I1 (no) 2011-09-19

Similar Documents

Publication Publication Date Title
AT501681B1 (de) Feste orale pharmazeutische zusammensetzung enthaltend 2-amino-1,3-propandiole
DE69629797T2 (de) Matrix zur gesteuerten freisetzung von arzneistoffen
DE69802543T2 (de) Verbesserte multipartikel-tablette mit schnellauflösbarkeit
DE69201793T2 (de) Mehrschichtige zubereitung mit kontrollierter freisetzung.
DE69902893T2 (de) Schnellauflösende efavirenz-kapseln oder tabletten durch verwendung von super-zersetzern
DE60222687T3 (de) Pharmazeutische zusammensetzungen enthaltend mycophenolsäure oder ein mycophenolat salz
DE69128569T2 (de) Tablette mit verzögerter Wirkstoffabgabe
DE69314950T2 (de) Okulaerdarreichungsform und verfahren zu ihrer herstellung
EP0250648B1 (de) Pharmazeutisches Präparat zur verzögerten Freigabe von Ibuprofen
DE20221486U1 (de) Tamsulosin-Tabletten mit modifizierter Freisetzung
CH648484A5 (de) Pharmazeutische zubereitung eines festen medikamentmaterials.
DE102004011512A1 (de) Pharmazeutische Zubereitung enthaltend Pimobendan
DE3232873A1 (de) Pharmazeutisches praeparat
EP1509207B1 (de) Pharmazeutische zusammensetzung, enthaltend oxcarbazepin mit kontrollierter wirkstofffreisetzung
DE10003757A1 (de) Ibuprofen-Wirkstoffzubereitung
DE69824313T2 (de) Sibutramin und orlistat enthaltende pharmazeutische zusammensetzungen
DE3719818A1 (de) Pharmazeutische zusammensetzungen
DE60216471T2 (de) Pharmazeutische zubereitungen mit einem cortisol synthese inhibitor
DE60203890T2 (de) Apfelsäureadditionssalze von terbinafin
DE10259619A1 (de) Verwendung einer TRPM8 aktivierenden Substanz zur Tumorbehandlung
DE3528481A1 (de) Neues pharmazeutisches praeparat
DE69021224T2 (de) Erosionsgesteuertes Freisetzungssystem für Wirkstoffe sowie Verfahren zu dessen Herstellung.
CH660303A5 (de) Analgetische praeparate.
EP1408943B1 (de) Arzneimittelformulierung enthaltend einen ltb4 antagonisten und einen netzmittel
DE60121142T2 (de) Zusammensetzung die paracetamol und niflumic säure enthält

Legal Events

Date Code Title Description
PC Change of the owner

Owner name: NOVARTIS AG, CH

Effective date: 20130715

Owner name: MITSUBISHI TANABE PHARMA CORPORATION, JP

Effective date: 20130715

MK07 Expiry

Effective date: 20240406