HRP20100601B1 - Kruti farmaceutski pripravci koji sadrže agonist s1p receptora i šećerni alkohol - Google Patents
Kruti farmaceutski pripravci koji sadrže agonist s1p receptora i šećerni alkohol Download PDFInfo
- Publication number
- HRP20100601B1 HRP20100601B1 HRP20100601AA HRP20100601A HRP20100601B1 HR P20100601 B1 HRP20100601 B1 HR P20100601B1 HR P20100601A A HRP20100601A A HR P20100601AA HR P20100601 A HRP20100601 A HR P20100601A HR P20100601 B1 HRP20100601 B1 HR P20100601B1
- Authority
- HR
- Croatia
- Prior art keywords
- receptor agonist
- sugar alcohol
- mixture
- alkyl
- mixing
- Prior art date
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- 229940044601 receptor agonist Drugs 0.000 title claims abstract description 35
- 239000000018 receptor agonist Substances 0.000 title claims abstract description 35
- 150000005846 sugar alcohols Chemical class 0.000 title claims abstract description 29
- 239000008194 pharmaceutical composition Substances 0.000 title claims abstract description 6
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- 108050001083 Sphingosine 1-phosphate receptors Proteins 0.000 claims abstract description 42
- 239000000203 mixture Substances 0.000 claims description 75
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims description 37
- 235000010355 mannitol Nutrition 0.000 claims description 33
- 238000000034 method Methods 0.000 claims description 32
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- 239000000594 mannitol Substances 0.000 claims description 29
- KKGQTZUTZRNORY-UHFFFAOYSA-N fingolimod Chemical group CCCCCCCCC1=CC=C(CCC(N)(CO)CO)C=C1 KKGQTZUTZRNORY-UHFFFAOYSA-N 0.000 claims description 24
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical group [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims description 24
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- QCQCHGYLTSGIGX-GHXANHINSA-N 4-[[(3ar,5ar,5br,7ar,9s,11ar,11br,13as)-5a,5b,8,8,11a-pentamethyl-3a-[(5-methylpyridine-3-carbonyl)amino]-2-oxo-1-propan-2-yl-4,5,6,7,7a,9,10,11,11b,12,13,13a-dodecahydro-3h-cyclopenta[a]chrysen-9-yl]oxy]-2,2-dimethyl-4-oxobutanoic acid Chemical compound N([C@@]12CC[C@@]3(C)[C@]4(C)CC[C@H]5C(C)(C)[C@@H](OC(=O)CC(C)(C)C(O)=O)CC[C@]5(C)[C@H]4CC[C@@H]3C1=C(C(C2)=O)C(C)C)C(=O)C1=CN=CC(C)=C1 QCQCHGYLTSGIGX-GHXANHINSA-N 0.000 claims description 2
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Abstract
Description
Claims (18)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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US46121503P | 2003-04-08 | 2003-04-08 | |
PCT/EP2004/003656 WO2004089341A1 (en) | 2003-04-08 | 2004-04-06 | Organic compounds |
Publications (2)
Publication Number | Publication Date |
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HRP20100601A2 HRP20100601A2 (hr) | 2011-03-31 |
HRP20100601B1 true HRP20100601B1 (hr) | 2016-12-02 |
Family
ID=32326722
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Application Number | Title | Priority Date | Filing Date |
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HR20050886A HRP20050886B1 (hr) | 2003-04-08 | 2005-10-06 | Kruti farmaceutski pripravci koji sadrze agonist s1p receptora i secerni alkohol |
HR20100600A HRP20100600A2 (hr) | 2003-04-08 | 2010-11-08 | Kruti farmaceutski pripravci koji sadrže agonist s1p receptora i šećerni alkohol |
HRP20100601AA HRP20100601B1 (hr) | 2003-04-08 | 2010-11-08 | Kruti farmaceutski pripravci koji sadrže agonist s1p receptora i šećerni alkohol |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
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HR20050886A HRP20050886B1 (hr) | 2003-04-08 | 2005-10-06 | Kruti farmaceutski pripravci koji sadrze agonist s1p receptora i secerni alkohol |
HR20100600A HRP20100600A2 (hr) | 2003-04-08 | 2010-11-08 | Kruti farmaceutski pripravci koji sadrže agonist s1p receptora i šećerni alkohol |
Country Status (42)
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2004
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- 2004-04-06 EP EP10186307A patent/EP2319502A1/en not_active Withdrawn
- 2004-04-06 IT IT000682A patent/ITMI20040682A1/it unknown
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- 2004-04-06 SI SI200432283T patent/SI2316431T1/sl unknown
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- 2004-04-06 HU HUE10184951A patent/HUE028247T2/en unknown
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- 2004-04-06 ES ES200400852A patent/ES2228282B1/es not_active Expired - Lifetime
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- 2004-04-06 EP EP14163450.1A patent/EP2769713A1/en not_active Withdrawn
- 2004-04-06 EP EP04725895A patent/EP1613288B1/en not_active Expired - Lifetime
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EP1002792A1 (en) * | 1997-04-04 | 2000-05-24 | Yoshitomi Pharmaceutical Industries, Ltd. | 2-aminopropane-1,3-diol compounds, medicinal use thereof, and intermediates in synthesizing the same |
EP1050301A1 (en) * | 1998-01-19 | 2000-11-08 | Yoshitomi Pharmaceutical Industries, Ltd. | Medicinal compositions |
WO2002018395A1 (en) * | 2000-08-31 | 2002-03-07 | Merck & Co., Inc. | Phosphate derivatives as immunoregulatory agents |
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