AR071479A1 - Hormona foliculo estimulante recombinante (rfsh) con union de acido sialico en a2,3 y a2,6 - Google Patents
Hormona foliculo estimulante recombinante (rfsh) con union de acido sialico en a2,3 y a2,6Info
- Publication number
- AR071479A1 AR071479A1 ARP090101333A ARP090101333A AR071479A1 AR 071479 A1 AR071479 A1 AR 071479A1 AR P090101333 A ARP090101333 A AR P090101333A AR P090101333 A ARP090101333 A AR P090101333A AR 071479 A1 AR071479 A1 AR 071479A1
- Authority
- AR
- Argentina
- Prior art keywords
- rfsh
- sialic acid
- recombinant
- hormone
- folicle
- Prior art date
Links
- SQVRNKJHWKZAKO-UHFFFAOYSA-N beta-N-Acetyl-D-neuraminic acid Natural products CC(=O)NC1C(O)CC(O)(C(O)=O)OC1C(O)C(O)CO SQVRNKJHWKZAKO-UHFFFAOYSA-N 0.000 title abstract 4
- SQVRNKJHWKZAKO-OQPLDHBCSA-N sialic acid Chemical compound CC(=O)N[C@@H]1[C@@H](O)C[C@@](O)(C(O)=O)OC1[C@H](O)[C@H](O)CO SQVRNKJHWKZAKO-OQPLDHBCSA-N 0.000 title abstract 4
- 229940088597 hormone Drugs 0.000 title 1
- 239000005556 hormone Substances 0.000 title 1
- 102000012673 Follicle Stimulating Hormone Human genes 0.000 abstract 2
- 108010079345 Follicle Stimulating Hormone Proteins 0.000 abstract 2
- 102000003838 Sialyltransferases Human genes 0.000 abstract 2
- 108090000141 Sialyltransferases Proteins 0.000 abstract 2
- 229940028334 follicle stimulating hormone Drugs 0.000 abstract 2
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000004720 fertilization Effects 0.000 abstract 1
- 238000010353 genetic engineering Methods 0.000 abstract 1
- 210000005260 human cell Anatomy 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000002611 ovarian Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000000638 stimulation Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/59—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g.hCG [human chorionic gonadotropin]; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/24—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g. HCG; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1048—Glycosyltransferases (2.4)
- C12N9/1081—Glycosyltransferases (2.4) transferring other glycosyl groups (2.4.99)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y204/00—Glycosyltransferases (2.4)
- C12Y204/99—Glycosyltransferases (2.4) transferring other glycosyl groups (2.4.99)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y204/00—Glycosyltransferases (2.4)
- C12Y204/99—Glycosyltransferases (2.4) transferring other glycosyl groups (2.4.99)
- C12Y204/99006—N-Acetyllactosaminide alpha-2,3-sialyltransferase (2.4.99.6)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Endocrinology (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Reproductive Health (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Wood Science & Technology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Toxicology (AREA)
- General Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Diabetes (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4542408P | 2008-04-16 | 2008-04-16 | |
| EP08251528 | 2008-04-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR071479A1 true AR071479A1 (es) | 2010-06-23 |
Family
ID=39717519
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP090101333A AR071479A1 (es) | 2008-04-16 | 2009-04-16 | Hormona foliculo estimulante recombinante (rfsh) con union de acido sialico en a2,3 y a2,6 |
Country Status (29)
| Country | Link |
|---|---|
| US (6) | US8951967B2 (https=) |
| EP (7) | EP3045471B1 (https=) |
| JP (7) | JP2011519359A (https=) |
| KR (5) | KR20160056960A (https=) |
| CN (3) | CN105906703A (https=) |
| AR (1) | AR071479A1 (https=) |
| AU (5) | AU2009237479B2 (https=) |
| BR (1) | BRPI0910461B8 (https=) |
| CA (1) | CA2725257A1 (https=) |
| CY (1) | CY1115413T1 (https=) |
| DK (6) | DK2808340T3 (https=) |
| ES (5) | ES2468318T3 (https=) |
| FI (4) | FI3098234T3 (https=) |
| FR (3) | FR17C1020I2 (https=) |
| HR (5) | HRP20140535T1 (https=) |
| HU (9) | HUE068565T2 (https=) |
| IL (2) | IL208538A (https=) |
| LT (8) | LT2808340T (https=) |
| MX (3) | MX355457B (https=) |
| NO (4) | NO2017025I1 (https=) |
| NZ (1) | NZ588381A (https=) |
| PL (6) | PL3144318T3 (https=) |
| PT (6) | PT3045471T (https=) |
| RU (3) | RU2682270C2 (https=) |
| SA (1) | SA109300228B1 (https=) |
| SI (6) | SI2268666T1 (https=) |
| TW (1) | TWI488640B (https=) |
| WO (1) | WO2009127826A1 (https=) |
| ZA (1) | ZA201007373B (https=) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI488640B (zh) | 2008-04-16 | 2015-06-21 | 菲瑞茵國際中心股份有限公司 | 藥學製劑 |
| TWI532495B (zh) | 2009-10-05 | 2016-05-11 | 菲瑞茵國際中心股份有限公司 | 藥學製劑 |
| EP2417982A1 (en) | 2010-07-30 | 2012-02-15 | Ferring B.V. | Stabilization of gonadotropins |
| WO2012016576A1 (en) * | 2010-08-04 | 2012-02-09 | Glycotope Gmbh | Improved recombinant human follicle-stimulating hormone |
| PT2621517E (pt) | 2010-09-29 | 2015-10-16 | Ferring Bv | Composição para uso no tratamento da infertilidade |
| WO2012050175A1 (ja) | 2010-10-15 | 2012-04-19 | 日本ケミカルリサーチ株式会社 | 糖鎖の非還元末端がマンノース残基である糖蛋白質の製造方法 |
| PL2691119T3 (pl) | 2011-03-31 | 2019-01-31 | Ferring B.V. | Preparat farmaceutyczny |
| EP2717904A1 (en) | 2011-06-06 | 2014-04-16 | Ferring BV | Pharmaceutical preparation comprising recombinant fsh |
| JO3092B1 (ar) * | 2011-08-08 | 2017-03-15 | Ferring Bv | مركب لتحفيز مسيطر عليه للمبيض |
| WO2013093760A2 (en) * | 2011-12-19 | 2013-06-27 | Grifols, S.A. | Compositions, methods, and kits for preparing sialylated recombinant proteins |
| US9657310B2 (en) * | 2012-04-27 | 2017-05-23 | Jcr Pharmaceuticals Co., Ltd. | Expression vector |
| EP2824176A1 (en) | 2013-07-11 | 2015-01-14 | Siamed'xpress | Methods for producing sialylated therapeutic proteins |
| JP6652334B2 (ja) * | 2014-05-31 | 2020-02-19 | Ｊｃｒファーマ株式会社 | ウリジンとｎ−アセチル−ｄ−マンノサミンとを含有する培地 |
| WO2016102436A1 (en) * | 2014-12-22 | 2016-06-30 | F. Hoffmann-La Roche Ag | Cmp-dependent sialidase activity |
| EP3283097B1 (en) | 2015-04-17 | 2020-02-12 | Ferring B.V. | Fsh for treatment of infertility |
| MY179524A (en) | 2015-06-26 | 2020-11-10 | Ferring Bv | Methods of purification and/or viral inactivation |
| EP3205719A1 (en) * | 2016-02-15 | 2017-08-16 | CEVEC Pharmaceuticals GmbH | Cell lines for producing recombinant glycoproteins with di-antennary n-glycans, methods using the same, and recombinant glycoproteins |
| GB201603280D0 (en) | 2016-02-24 | 2016-04-13 | Ferring Bv | Stable liquid gonadotropin formulation |
| EP3382014A1 (en) * | 2017-03-29 | 2018-10-03 | CEVEC Pharmaceuticals GmbH | Recombinant glycoproteins with reduced antennary fucosylation |
| EP3441471A1 (en) | 2017-08-08 | 2019-02-13 | CEVEC Pharmaceuticals GmbH | Use of constitutively active variants of growth factor receptors as selection makers for the generation of stable producer cell lines |
| MX2020002235A (es) | 2017-09-01 | 2020-07-20 | Ferring Bv | Composicion para la estimulacion ovarica controlada. |
| HUE071268T2 (hu) | 2018-04-30 | 2025-08-28 | Ferring Bv | Készítmény szabályozott petefészek-stimuláláshoz |
| TWI846743B (zh) | 2018-10-17 | 2024-07-01 | 荷蘭商菲林公司 | 用於控制性卵巢刺激之組成物及方法 |
| US20220380785A1 (en) * | 2019-11-01 | 2022-12-01 | The University Of British Columbia | Compositions and methods for sialylated mucin-type o-glycosylation of therapeutic proteins |
| TW202237173A (zh) | 2020-12-09 | 2022-10-01 | 荷蘭商菲林公司 | 用於受控的卵巢刺激之組成物及方法 |
| KR20240167660A (ko) | 2022-04-01 | 2024-11-27 | 훼링 비.브이. | 불임의 치료를 위한 혼합 프로토콜 |
| AU2023275943A1 (en) | 2022-05-26 | 2024-10-17 | Ferring B.V. | Compositions and methods for treatment of infertility in males |
| KR20250033230A (ko) | 2022-07-08 | 2025-03-07 | 훼링 비.브이. | 자궁내 인공수정(iui)을 위한 조성물 및 방법 |
| AR133300A1 (es) | 2023-07-20 | 2025-09-17 | Ferring Bv | Micropartículas cargadas con fármaco de liberación prolongada |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1206302B (it) | 1987-06-26 | 1989-04-14 | Serono Cesare Ist Ricerca | Ormone follicolo-stimolante urinario |
| US5541083A (en) | 1989-10-24 | 1996-07-30 | The Regents Of The University Of California | Method for producing secretable glycosyltransferases and other golgi processing enzymes |
| IL160406A0 (en) | 1995-06-15 | 2004-07-25 | Crucell Holland Bv | A cell harbouring nucleic acid encoding adenoritus e1a and e1b gene products |
| JP3559652B2 (ja) * | 1996-06-25 | 2004-09-02 | グローリー工業株式会社 | 売上精算システムの管理装置 |
| IL122732A0 (en) * | 1997-01-15 | 1998-08-16 | Akzo Nobel Nv | Liquid gonadotropin-containing formulation its preparation and a device containing same |
| JP2001507215A (ja) | 1997-01-16 | 2001-06-05 | サイテル コーポレイション | 組換え糖タンパク質のインビトロでの実用的なシアリル化 |
| JPH1111665A (ja) | 1997-06-28 | 1999-01-19 | Shibuya Kogyo Co Ltd | 無菌エア搬送コンベヤ装置 |
| TWI235158B (en) * | 1997-09-01 | 2005-07-01 | Kirin Brewery | Human thrombopoietin produced by human established cell lines, processes foe preparing the same, and pharmaceutical composition comprising the same |
| PT1176976E (pt) | 1999-05-07 | 2006-11-30 | Applied Research Systems | Utilização de lh administrada na fase folicular média e tardia para o tratamento de mulheres anovulatórias. |
| JP2002011665A (ja) | 2000-06-28 | 2002-01-15 | Sintokogio Ltd | ショットブラスト装置モニタシステム |
| IL140110A0 (en) | 2000-12-05 | 2002-02-10 | Applied Research Systems | Improvement of homogeneity and secretion of recombinant proteins in mammalian systems |
| MEP38608A (en) * | 2001-10-22 | 2011-02-10 | Merck Serono Sa | Gonadotrophins for folliculogenesis |
| ATE542904T1 (de) | 2001-10-29 | 2012-02-15 | Crucell Holland Bv | Verfahren und mittel zur herstellung von proteinen mit vorbestimmten posttranslationalen modifikationen |
| PT1465987E (pt) | 2001-12-07 | 2008-04-15 | Crucell Holland Bv | Produção de vírus, isolados virais e vacinas |
| US20040248784A1 (en) | 2003-06-03 | 2004-12-09 | Marco Filicori | Unitary combinations of FSH and hCG |
| JP2007515410A (ja) * | 2003-12-03 | 2007-06-14 | ネオス テクノロジーズ インコーポレイテッド | ＧｌｙｃｏＰＥＧ化卵胞刺激ホルモン |
| ES2350298T3 (es) | 2004-02-04 | 2011-01-20 | Centre National De La Recherche Scientifique | Procedimiento para el cribado de anticuerpos específicos de glicoforma. |
| CN103627670B (zh) * | 2004-02-13 | 2016-12-21 | 格莱克托普有限公司 | 高活性糖蛋白加工条件及其有效生产方法 |
| TWI488640B (zh) | 2008-04-16 | 2015-06-21 | 菲瑞茵國際中心股份有限公司 | 藥學製劑 |
| TWI532495B (zh) | 2009-10-05 | 2016-05-11 | 菲瑞茵國際中心股份有限公司 | 藥學製劑 |
| EP2417982A1 (en) | 2010-07-30 | 2012-02-15 | Ferring B.V. | Stabilization of gonadotropins |
| US8790322B2 (en) | 2010-08-03 | 2014-07-29 | King Saud University | Stoma coat |
| WO2012016576A1 (en) * | 2010-08-04 | 2012-02-09 | Glycotope Gmbh | Improved recombinant human follicle-stimulating hormone |
| PT2621517E (pt) | 2010-09-29 | 2015-10-16 | Ferring Bv | Composição para uso no tratamento da infertilidade |
| PL2691119T3 (pl) | 2011-03-31 | 2019-01-31 | Ferring B.V. | Preparat farmaceutyczny |
| EP2717904A1 (en) | 2011-06-06 | 2014-04-16 | Ferring BV | Pharmaceutical preparation comprising recombinant fsh |
| JO3092B1 (ar) | 2011-08-08 | 2017-03-15 | Ferring Bv | مركب لتحفيز مسيطر عليه للمبيض |
| MX2016013449A (es) | 2014-04-18 | 2017-05-04 | Glycotope Gmbh | Hiperestimulacion ovarica controlada con la hormona estimuladora folicular humana recombinante mejorada. |
-
2009
- 2009-04-15 TW TW098112483A patent/TWI488640B/zh active
- 2009-04-16 CN CN201510933827.2A patent/CN105906703A/zh active Pending
- 2009-04-16 HU HUE16179121A patent/HUE068565T2/hu unknown
- 2009-04-16 SI SI200930931T patent/SI2268666T1/sl unknown
- 2009-04-16 CN CN201510933782.9A patent/CN105906702A/zh active Pending
- 2009-04-16 NZ NZ588381A patent/NZ588381A/en unknown
- 2009-04-16 ES ES09733497.3T patent/ES2468318T3/es active Active
- 2009-04-16 FI FIEP16179121.5T patent/FI3098234T3/fi active
- 2009-04-16 SI SI200931670A patent/SI3045471T1/sl unknown
- 2009-04-16 SI SI200932209T patent/SI4015527T1/sl unknown
- 2009-04-16 LT LTEP14178729.1T patent/LT2808340T/lt unknown
- 2009-04-16 MX MX2017007881A patent/MX355457B/es unknown
- 2009-04-16 MX MX2014011348A patent/MX348622B/es unknown
- 2009-04-16 PL PL16194925T patent/PL3144318T3/pl unknown
- 2009-04-16 EP EP16158141.8A patent/EP3045471B1/en not_active Revoked
- 2009-04-16 LT LTEP16179121.5T patent/LT3098234T/lt unknown
- 2009-04-16 AR ARP090101333A patent/AR071479A1/es not_active Application Discontinuation
- 2009-04-16 JP JP2011504527A patent/JP2011519359A/ja active Pending
- 2009-04-16 PT PT161581418T patent/PT3045471T/pt unknown
- 2009-04-16 BR BRPI0910461A patent/BRPI0910461B8/pt active IP Right Grant
- 2009-04-16 ES ES16179121T patent/ES2989729T3/es active Active
- 2009-04-16 EP EP16194925.0A patent/EP3144318B1/en active Active
- 2009-04-16 KR KR1020167012148A patent/KR20160056960A/ko not_active Ceased
- 2009-04-16 FI FIEP21212873.0T patent/FI4015527T3/fi active
- 2009-04-16 MX MX2010011343A patent/MX2010011343A/es active IP Right Grant
- 2009-04-16 HU HUE21212873A patent/HUE071059T2/hu unknown
- 2009-04-16 PT PT97334973T patent/PT2268666E/pt unknown
- 2009-04-16 SI SI200932094T patent/SI3144318T1/sl unknown
- 2009-04-16 PT PT161949250T patent/PT3144318T/pt unknown
- 2009-04-16 WO PCT/GB2009/000978 patent/WO2009127826A1/en not_active Ceased
- 2009-04-16 DK DK14178729.1T patent/DK2808340T3/en active
- 2009-04-16 PL PL09733497T patent/PL2268666T3/pl unknown
- 2009-04-16 EP EP14178729.1A patent/EP2808340B1/en not_active Revoked
- 2009-04-16 SI SI200932205T patent/SI3098234T1/sl unknown
- 2009-04-16 RU RU2014141994A patent/RU2682270C2/ru active
- 2009-04-16 KR KR1020177026920A patent/KR20170110741A/ko not_active Ceased
- 2009-04-16 PL PL21212873.0T patent/PL4015527T3/pl unknown
- 2009-04-16 PT PT141787291T patent/PT2808340T/pt unknown
- 2009-04-16 PL PL16179121.5T patent/PL3098234T3/pl unknown
- 2009-04-16 RU RU2010141908/10A patent/RU2537268C2/ru active
- 2009-04-16 EP EP09733497.3A patent/EP2268666B1/en not_active Revoked
- 2009-04-16 PT PT212128730T patent/PT4015527T/pt unknown
- 2009-04-16 HU HUE16158141A patent/HUE033830T2/en unknown
- 2009-04-16 EP EP13193214.7A patent/EP2722339A1/en active Pending
- 2009-04-16 DK DK16194925.0T patent/DK3144318T3/da active
- 2009-04-16 DK DK09733497.3T patent/DK2268666T3/da active
- 2009-04-16 HU HUE14178729A patent/HUE030652T4/en unknown
- 2009-04-16 SI SI200931547A patent/SI2808340T1/sl unknown
- 2009-04-16 US US12/988,218 patent/US8951967B2/en active Active
- 2009-04-16 HR HRP20140535AT patent/HRP20140535T1/hr unknown
- 2009-04-16 PT PT161791215T patent/PT3098234T/pt unknown
- 2009-04-16 DK DK21212873.0T patent/DK4015527T3/da active
- 2009-04-16 KR KR1020107025581A patent/KR101622944B1/ko active Active
- 2009-04-16 LT LTEP21212873.0T patent/LT4015527T/lt unknown
- 2009-04-16 HR HRP20250313TT patent/HRP20250313T1/hr unknown
- 2009-04-16 ES ES21212873T patent/ES3023526T3/es active Active
- 2009-04-16 HR HRP20241187TT patent/HRP20241187T1/hr unknown
- 2009-04-16 DK DK16158141.8T patent/DK3045471T3/en active
- 2009-04-16 DK DK16179121.5T patent/DK3098234T3/da active
- 2009-04-16 AU AU2009237479A patent/AU2009237479B2/en active Active
- 2009-04-16 CA CA2725257A patent/CA2725257A1/en active Pending
- 2009-04-16 LT LTEP16158141.8T patent/LT3045471T/lt unknown
- 2009-04-16 ES ES16158141.8T patent/ES2629392T3/es active Active
- 2009-04-16 CN CN200980121391XA patent/CN102066414A/zh active Pending
- 2009-04-16 ES ES14178729.1T patent/ES2610277T3/es active Active
- 2009-04-16 KR KR1020197022294A patent/KR102108377B1/ko not_active Expired - Fee Related
- 2009-04-16 KR KR1020187023820A patent/KR20180095140A/ko not_active Ceased
- 2009-04-16 PL PL14178729T patent/PL2808340T3/pl unknown
- 2009-04-16 PL PL16158141T patent/PL3045471T3/pl unknown
- 2009-04-16 EP EP21212873.0A patent/EP4015527B1/en active Active
- 2009-04-16 EP EP16179121.5A patent/EP3098234B1/en active Active
- 2009-04-18 SA SA109300228A patent/SA109300228B1/ar unknown
-
2010
- 2010-10-07 IL IL208538A patent/IL208538A/en active Protection Beyond IP Right Term
- 2010-10-14 ZA ZA2010/07373A patent/ZA201007373B/en unknown
-
2014
- 2014-01-21 IL IL230571A patent/IL230571A/en active IP Right Grant
- 2014-06-06 CY CY20141100402T patent/CY1115413T1/el unknown
- 2014-06-17 AU AU2014203277A patent/AU2014203277C1/en active Active
- 2014-11-14 US US14/541,852 patent/US9546204B2/en active Active
- 2014-12-25 JP JP2014262056A patent/JP2015120696A/ja active Pending
-
2016
- 2016-08-16 US US15/238,362 patent/US9771407B2/en active Active
- 2016-10-07 JP JP2016198588A patent/JP6486310B2/ja active Active
- 2016-11-16 HR HRP20161520TT patent/HRP20161520T1/hr unknown
-
2017
- 2017-05-30 HU HUS1700024C patent/HUS1700024I1/hu unknown
- 2017-05-31 HU HUS1700025C patent/HUS1700025I1/hu unknown
- 2017-06-05 LT LTPA2017018C patent/LTPA2017018I1/lt unknown
- 2017-06-06 FR FR17C1020C patent/FR17C1020I2/fr active Active
- 2017-06-06 NO NO2017025C patent/NO2017025I1/no unknown
- 2017-06-23 AU AU2017204259A patent/AU2017204259B2/en active Active
- 2017-06-23 AU AU2017204258A patent/AU2017204258B2/en active Active
- 2017-06-26 HR HRP20170958TT patent/HRP20170958T1/hr unknown
- 2017-08-01 JP JP2017148823A patent/JP6762916B2/ja active Active
- 2017-08-29 US US15/690,061 patent/US10995128B2/en active Active
- 2017-09-05 AU AU2017225020A patent/AU2017225020B2/en active Active
- 2017-09-27 LT LTPA2017029C patent/LTPA2017029I1/lt unknown
- 2017-09-27 HU HUS1700036C patent/HUS1700036I1/hu unknown
- 2017-09-28 NO NO2017050C patent/NO2017050I1/no unknown
-
2018
- 2018-11-08 RU RU2018139379A patent/RU2745557C3/ru active Protection Beyond IP Right Term
-
2019
- 2019-10-25 JP JP2019194476A patent/JP7316905B2/ja active Active
-
2021
- 2021-04-30 US US17/246,348 patent/US11952407B2/en active Active
- 2021-10-27 JP JP2021175403A patent/JP2022031652A/ja active Pending
-
2023
- 2023-12-21 JP JP2023215339A patent/JP2024038000A/ja active Pending
-
2024
- 2024-03-14 US US18/605,381 patent/US12516094B2/en active Active
-
2025
- 2025-01-15 FI FIC20250003C patent/FIC20250003I1/fi unknown
- 2025-01-16 NO NO2025006C patent/NO2025006I1/no unknown
- 2025-01-16 FR FR25C1003C patent/FR25C1003I1/fr active Active
- 2025-01-24 LT LTPA2025505C patent/LTPA2025505I1/lt unknown
- 2025-01-28 HU HUS2500008C patent/HUS2500008I1/hu unknown
- 2025-07-02 FR FR25C1025C patent/FR25C1025I1/fr active Active
- 2025-07-07 LT LTPA2025525C patent/LTPA2025525I1/lt unknown
- 2025-07-07 HU HUS2500029C patent/HUS2500029I1/hu unknown
- 2025-07-11 FI FIC20250025C patent/FIC20250025I1/fi unknown
- 2025-07-14 NO NO2025032C patent/NO2025032I1/no unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AR071479A1 (es) | Hormona foliculo estimulante recombinante (rfsh) con union de acido sialico en a2,3 y a2,6 | |
| Mathes et al. | The use of skin models in drug development | |
| BRPI0915142A8 (pt) | Polipeptídeos, ácido nucleico e usos dos mesmos | |
| MX2015013118A (es) | Composiciones y métodos para la producción y administración de ácido ribonucleico. | |
| AR082852A1 (es) | Hormona foliculoestimulante humana recombinante, composicion farmaceutica que la comprende y uso de la misma | |
| RU2012105922A (ru) | Дифференцирование человеческих эмбриональных стволовых клеток | |
| MY160680A (en) | Process for producing molecules containing specialized glycan structures | |
| BR112012008848A2 (pt) | composição, e, método in vitro ou ex vivo para induzir células de mamífero não-pluripotente em células tronco pluripotentes induzidas | |
| BR112013012697A2 (pt) | "método para diminuir expressão, produção ou secreção de um fator angiogênico ou fator hipertrófico ou ambos por células-tronco mesenquimais, métodos para diminuir um efeito inibidor, um efeito deletério, e um efeito de apoptose de células-tronco mesenquimais, método para aumentar um efeito estimulador de células-tronco mesenquimais, composição, e, método para preparar cartilagem em um indivíduo diagnosticado com cartilagem doente ou danificada." | |
| BR112012007854A2 (pt) | metodos de produção de glicoproteínas em culturas de células de mamíferos usando glicocorticoides | |
| CL2011000792A1 (es) | Acido nucleico aislado que codifica mutante del factor de crecimiento de fibroblastos 21 (fgf21); vector; celula huesped; fgf21 mutante; proceso de produccion; composicion farmaceutica que lo comprende; y metodo para tratar un trastorno metabolico. | |
| WO2009137624A3 (en) | Hemangio colony forming cells and non-engrafting hemangio cells | |
| AR079876A1 (es) | Gonadotrofina corionica humana recombinante con alto contenido de acido sialico y uso farmaceutico de la misma | |
| BR112012009973A2 (pt) | promotor de regeneração de tecido usando recrutamento de células-tronco mesenquimais da medula óssea e/ou células-tronco pluripotentes em sangue | |
| PE20081555A1 (es) | Uso de agonistas del receptor de glp-1 de accion prolongada para mejorar la sensibilidad a la insulina y los perfiles lipidicos | |
| BR112012026907A2 (pt) | método para a preparação de uma microvesícula suportando tf tendo atividade pró-coagulante, microvesículas obstidas pelo dito metodo e seu uso, bem como composição farmacêutica e kit as compreendendo | |
| WO2011163531A3 (en) | Compositions and methods for re-programming cells without genetic modification for treatment of cardiovascular diseases | |
| PE20140647A1 (es) | Metodo para tratamiento de cancer de pulmon de celulas no pequenas | |
| BR112012015449A2 (pt) | suspensão de monoidrato de calcipotriol, monoidrato de calcipotriol, processo para preparar nanocristais de monoidrato de calcipotriol, e, composição farmacêutica | |
| BR0306318A (pt) | Co-implantação sinérgìstica de instalações de processo | |
| AR085003A1 (es) | Composicion biopolimerica para el encapsulamiento de celulas, metodo de produccion de una composicion biopolimerica para el encapsulamiento de celulas, metodo para promover la citoproteccion de celulas y uso de una composicion biopolimerica para el encapsulamiento de celulas | |
| EP2602310A4 (en) | A SYSTEM FOR CULTURING CARRIER-CONTAINING BONE MARROW CELLS, A METHOD FOR CULTURING CARRIER-CONTAINING BONE MARROW CELLS, AND METHOD FOR PRODUCING A MEDICAL COMPOSITION USING CULTURED AUTOSERUM-CONTAINING BONE MARROW CELLS AS AN ACTIVE SUBSTANCE | |
| WO2014006452A3 (en) | Rapid alkalinization factor peptides for delivery of nucleic acid molecules into cells | |
| BR112015004965A2 (pt) | silenciamento de gene transcricional de endogenes em plantas | |
| WO2014022283A3 (en) | Glycoprotein hormone long-acting superagonists |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC | Refusal |