BR112012026907A2 - método para a preparação de uma microvesícula suportando tf tendo atividade pró-coagulante, microvesículas obstidas pelo dito metodo e seu uso, bem como composição farmacêutica e kit as compreendendo - Google Patents
método para a preparação de uma microvesícula suportando tf tendo atividade pró-coagulante, microvesículas obstidas pelo dito metodo e seu uso, bem como composição farmacêutica e kit as compreendendoInfo
- Publication number
- BR112012026907A2 BR112012026907A2 BR112012026907A BR112012026907A BR112012026907A2 BR 112012026907 A2 BR112012026907 A2 BR 112012026907A2 BR 112012026907 A BR112012026907 A BR 112012026907A BR 112012026907 A BR112012026907 A BR 112012026907A BR 112012026907 A2 BR112012026907 A2 BR 112012026907A2
- Authority
- BR
- Brazil
- Prior art keywords
- well
- microvesicles
- hampered
- kit
- preparation
- Prior art date
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/36—Blood coagulation or fibrinolysis factors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/36—Extraction; Separation; Purification by a combination of two or more processes of different types
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70596—Molecules with a "CD"-designation not provided for elsewhere
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Toxicology (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cell Biology (AREA)
- Analytical Chemistry (AREA)
- Dispersion Chemistry (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Dermatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
- Materials For Medical Uses (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
vesículas enriquecidas por fosfolipídios suportando o fator tecidual tendo atividades hemostáticas e usos das mesmas. a presente invenção refere-se a um método para melhorar as propriedades pró-coagulantes de tf expressas em células eucarióticas por meio de contato com derivados de microvesículas a partir das ditas células eucarióticas com um fosfolipideo carregado de forma negativa, como a fosfatidilserina. a presente invenção também se refere às microvesículas obtidas utilizando o dito método, bem como aos usos das mesmas como agentes pró-coagulantes, para cicatrização de feridas e para a promoção da angiogênese.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP10382085A EP2380905A1 (en) | 2010-04-19 | 2010-04-19 | Phospholipid-enriched vesicles bearing tissue factor having haemostatic activities and uses thereof |
| PCT/EP2011/056219 WO2011131658A1 (en) | 2010-04-19 | 2011-04-19 | Phospholipid-enriched vesicles bearing tissue factor having haemostatic activities and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112012026907A2 true BR112012026907A2 (pt) | 2017-01-10 |
Family
ID=42541341
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112012026907A BR112012026907A2 (pt) | 2010-04-19 | 2011-04-19 | método para a preparação de uma microvesícula suportando tf tendo atividade pró-coagulante, microvesículas obstidas pelo dito metodo e seu uso, bem como composição farmacêutica e kit as compreendendo |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US8735351B2 (pt) |
| EP (2) | EP2380905A1 (pt) |
| JP (1) | JP5857035B2 (pt) |
| KR (1) | KR101884954B1 (pt) |
| CN (1) | CN102892781B (pt) |
| AU (1) | AU2011244379B2 (pt) |
| BR (1) | BR112012026907A2 (pt) |
| CA (1) | CA2796266C (pt) |
| CY (1) | CY1116940T1 (pt) |
| DK (1) | DK2560991T3 (pt) |
| ES (1) | ES2553228T3 (pt) |
| HR (1) | HRP20151145T1 (pt) |
| HU (1) | HUE025837T2 (pt) |
| MX (1) | MX2012012135A (pt) |
| PL (1) | PL2560991T3 (pt) |
| PT (1) | PT2560991E (pt) |
| RU (1) | RU2595406C2 (pt) |
| SI (1) | SI2560991T1 (pt) |
| WO (1) | WO2011131658A1 (pt) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2745852A1 (en) * | 2012-12-21 | 2014-06-25 | Thrombotargets Europe, S.L. | Sealant compositions |
| EP2759305A1 (en) * | 2013-01-24 | 2014-07-30 | Thrombotargets Europe, S.L. | Hemostatic compositions |
| US9687511B2 (en) * | 2015-03-06 | 2017-06-27 | Vivex Biomedical, Inc. | Acellular biologic composition and method of manufacture |
| CN106692984B (zh) * | 2016-12-08 | 2020-02-18 | 武汉大学 | 一种基于细胞源性微囊泡的肿瘤靶向递送载体及制备方法和应用 |
| KR101999818B1 (ko) * | 2017-07-26 | 2019-07-12 | ㈜로제타엑소좀 | 소수성 상호작용을 이용한 세포밖 소포체의 분리방법 |
| CN108159421B (zh) * | 2018-02-05 | 2021-05-18 | 苏州大学 | 磷脂酰丝氨酸阻断剂在制备治疗血小板数量减少相关疾病药物中的用途 |
| WO2019185874A1 (en) * | 2018-03-30 | 2019-10-03 | Exosomics S.p.A. | Use of hollow fibers to obtain blood or a blood derivative impoverished from blood cells and platelets derived extracellular vesicles |
| CN109293780B (zh) * | 2018-09-04 | 2021-05-07 | 厦门宏谱福生物科技有限公司 | 一种人组织因子凝血复合物及其制备方法 |
| CN113134014B (zh) * | 2020-01-20 | 2023-09-26 | 医微细胞生物技术(广州)有限公司 | 囊泡在制备血友病药物中的应用 |
| KR20210117192A (ko) | 2020-03-16 | 2021-09-28 | 주식회사 엑소스템텍 | 기능성 엑소좀 제조를 위한 십자류 여과장치의 새로운 용도 |
| CN112322583B (zh) * | 2020-09-28 | 2024-02-02 | 上海思路迪生物医学科技有限公司 | 基于凝血的细胞外囊泡捕获技术 |
| CN112843072A (zh) * | 2021-01-12 | 2021-05-28 | 山东省科学院生物研究所 | 磷脂在调控血管生成方面的应用 |
| KR102431378B1 (ko) * | 2021-03-25 | 2022-08-09 | 인천대학교 산학협력단 | 세포밖 소포체의 표면 단백질 및 핵산 분석방법 |
| CN113117138A (zh) * | 2021-05-19 | 2021-07-16 | 中国石油大学(华东) | 负载组织因子及二氧化硅的胶原蛋白水凝胶止血敷料 |
| CN113262323A (zh) * | 2021-05-19 | 2021-08-17 | 中国石油大学(华东) | 负载组织因子的碳酸钙微粒自推动止血敷料 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL63270A0 (en) | 1980-08-05 | 1981-10-30 | Univ Leland Stanford Junior | Eukaryotic autonomously replicating segment |
| NZ199722A (en) | 1981-02-25 | 1985-12-13 | Genentech Inc | Dna transfer vector for expression of exogenous polypeptide in yeast;transformed yeast strain |
| US5223427A (en) | 1987-03-31 | 1993-06-29 | The Scripps Research Institute | Hybridomas producing monoclonal antibodies reactive with human tissue-factor glycoprotein heavy chain |
| US6130074A (en) | 1992-06-01 | 2000-10-10 | American Cyanamid Company Five Giralda Farms | Recombinant insect virus with reduced capacity for host-to-host transmission in the environment and methods to produce said virus |
| ATE398679T1 (de) | 1992-07-07 | 2008-07-15 | Japan Tobacco Inc | Verfahren zur transformation einer monokotyledon pflanze |
| US6596712B2 (en) | 1996-04-26 | 2003-07-22 | Genaera Corporation | Treatment of carcinomas using squalamine in combination with other anti-cancer agents or modalities |
| AU7129598A (en) * | 1997-04-23 | 1998-11-13 | Instrumentation Laboratory S.P.A. | Recombinant rabbit tissue factor based prothrombin time reagent |
| US6399384B1 (en) | 1999-09-17 | 2002-06-04 | Reneuron Limited | Conditional immortalization of cells |
| US6645768B1 (en) * | 2000-10-27 | 2003-11-11 | Biomerieux, Inc. | Reagent and kit for determining global coagulability and hemostatic potential |
| US7622437B2 (en) * | 2000-11-20 | 2009-11-24 | The Board Of Trustees Of The University Of Illinois | Tissue factor compositions and methods |
| US20030084482A1 (en) | 2001-06-08 | 2003-05-01 | Gerald Hall | Production of proteins in plants |
| JP2005510207A (ja) | 2001-07-27 | 2005-04-21 | イコン ジェネティクス インコーポレイティッド | 人及び動物の治療用又は診断用タンパク質を製造するための、アラビドプシスの工業的利用 |
| US20050221414A1 (en) * | 2004-03-31 | 2005-10-06 | Katalin Varadi | Kit for measuring the thrombin generation in a sample of a patient's blood or plasma |
| US20070292490A1 (en) | 2004-06-25 | 2007-12-20 | Valentin Negrouk | Production of tissue factor in plants |
| US7148067B2 (en) * | 2004-08-31 | 2006-12-12 | The Board Of Trustees Of The University Of Illinois | Thromboplastin reagents |
| JP2007091599A (ja) * | 2005-09-27 | 2007-04-12 | Shino Test Corp | 血液凝固反応促進剤 |
| JP5073270B2 (ja) | 2006-11-14 | 2012-11-14 | シスメックス株式会社 | 凝固検査用試薬及びその製造方法 |
| EP1939218A1 (en) | 2006-12-29 | 2008-07-02 | Thrombotargets Europe, S.L. | Microvesicles derived from recombinant yeast having haemostatic activities and uses thereof |
-
2010
- 2010-04-19 EP EP10382085A patent/EP2380905A1/en not_active Withdrawn
-
2011
- 2011-04-19 PT PT117149906T patent/PT2560991E/pt unknown
- 2011-04-19 CA CA2796266A patent/CA2796266C/en not_active Expired - Fee Related
- 2011-04-19 PL PL11714990T patent/PL2560991T3/pl unknown
- 2011-04-19 EP EP11714990.6A patent/EP2560991B1/en active Active
- 2011-04-19 SI SI201130650A patent/SI2560991T1/sl unknown
- 2011-04-19 ES ES11714990.6T patent/ES2553228T3/es active Active
- 2011-04-19 HU HUE11714990A patent/HUE025837T2/en unknown
- 2011-04-19 JP JP2013505451A patent/JP5857035B2/ja not_active Expired - Fee Related
- 2011-04-19 BR BR112012026907A patent/BR112012026907A2/pt not_active Application Discontinuation
- 2011-04-19 CN CN201180024574.7A patent/CN102892781B/zh not_active Expired - Fee Related
- 2011-04-19 WO PCT/EP2011/056219 patent/WO2011131658A1/en active Application Filing
- 2011-04-19 AU AU2011244379A patent/AU2011244379B2/en not_active Ceased
- 2011-04-19 RU RU2012148903/10A patent/RU2595406C2/ru active
- 2011-04-19 KR KR1020127030201A patent/KR101884954B1/ko active IP Right Grant
- 2011-04-19 DK DK11714990.6T patent/DK2560991T3/en active
- 2011-04-19 MX MX2012012135A patent/MX2012012135A/es active IP Right Grant
- 2011-04-19 US US13/642,491 patent/US8735351B2/en not_active Expired - Fee Related
-
2015
- 2015-10-28 HR HRP20151145TT patent/HRP20151145T1/hr unknown
- 2015-11-16 CY CY20151101029T patent/CY1116940T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2011244379B2 (en) | 2016-06-09 |
| CA2796266C (en) | 2018-06-05 |
| US8735351B2 (en) | 2014-05-27 |
| KR20130093508A (ko) | 2013-08-22 |
| EP2380905A1 (en) | 2011-10-26 |
| EP2560991B1 (en) | 2015-08-19 |
| JP5857035B2 (ja) | 2016-02-10 |
| CN102892781A (zh) | 2013-01-23 |
| MX2012012135A (es) | 2013-02-27 |
| RU2012148903A (ru) | 2014-05-27 |
| CY1116940T1 (el) | 2017-04-05 |
| DK2560991T3 (en) | 2015-11-02 |
| HUE025837T2 (en) | 2016-04-28 |
| SI2560991T1 (sl) | 2016-06-30 |
| CA2796266A1 (en) | 2011-10-27 |
| KR101884954B1 (ko) | 2018-08-02 |
| PL2560991T3 (pl) | 2016-01-29 |
| EP2560991A1 (en) | 2013-02-27 |
| WO2011131658A1 (en) | 2011-10-27 |
| CN102892781B (zh) | 2015-09-02 |
| ES2553228T3 (es) | 2015-12-07 |
| US20130059782A1 (en) | 2013-03-07 |
| RU2595406C2 (ru) | 2016-08-27 |
| PT2560991E (pt) | 2015-11-20 |
| HRP20151145T1 (hr) | 2015-12-18 |
| JP2013525326A (ja) | 2013-06-20 |
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