AR042052A1 - Diaminotriazoles utiles como inhibidores de proteinquinasas - Google Patents
Diaminotriazoles utiles como inhibidores de proteinquinasasInfo
- Publication number
- AR042052A1 AR042052A1 ARP030104218A ARP030104218A AR042052A1 AR 042052 A1 AR042052 A1 AR 042052A1 AR P030104218 A ARP030104218 A AR P030104218A AR P030104218 A ARP030104218 A AR P030104218A AR 042052 A1 AR042052 A1 AR 042052A1
- Authority
- AR
- Argentina
- Prior art keywords
- phenyl
- unsubstituted
- substituted
- optionally substituted
- formula
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 24
- 125000005842 heteroatom Chemical group 0.000 abstract 11
- 229910052760 oxygen Inorganic materials 0.000 abstract 11
- 150000001875 compounds Chemical class 0.000 abstract 10
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 8
- 125000004076 pyridyl group Chemical group 0.000 abstract 8
- 125000002950 monocyclic group Chemical group 0.000 abstract 7
- 229920006395 saturated elastomer Polymers 0.000 abstract 7
- 125000001118 alkylidene group Chemical group 0.000 abstract 5
- 125000002619 bicyclic group Chemical group 0.000 abstract 5
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 abstract 5
- -1 trazol Chemical compound 0.000 abstract 5
- SMWDFEZZVXVKRB-UHFFFAOYSA-N anhydrous quinoline Natural products N1=CC=CC2=CC=CC=C21 SMWDFEZZVXVKRB-UHFFFAOYSA-N 0.000 abstract 4
- 125000002943 quinolinyl group Chemical class N1=C(C=CC2=CC=CC=C12)* 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 3
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 3
- 229910052736 halogen Inorganic materials 0.000 abstract 3
- 150000002367 halogens Chemical class 0.000 abstract 3
- ZCQWOFVYLHDMMC-UHFFFAOYSA-N Oxazole Chemical compound C1=COC=N1 ZCQWOFVYLHDMMC-UHFFFAOYSA-N 0.000 abstract 2
- 125000001931 aliphatic group Chemical group 0.000 abstract 2
- 125000004429 atom Chemical group 0.000 abstract 2
- 125000000714 pyrimidinyl group Chemical group 0.000 abstract 2
- 125000003107 substituted aryl group Chemical group 0.000 abstract 2
- 229910052717 sulfur Inorganic materials 0.000 abstract 2
- NAWXUBYGYWOOIX-SFHVURJKSA-N (2s)-2-[[4-[2-(2,4-diaminoquinazolin-6-yl)ethyl]benzoyl]amino]-4-methylidenepentanedioic acid Chemical compound C1=CC2=NC(N)=NC(N)=C2C=C1CCC1=CC=C(C(=O)N[C@@H](CC(=C)C(O)=O)C(O)=O)C=C1 NAWXUBYGYWOOIX-SFHVURJKSA-N 0.000 abstract 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- DQSBZDLZCZUJCJ-UHFFFAOYSA-N 2h-triazole-4,5-diamine Chemical class NC=1N=NNC=1N DQSBZDLZCZUJCJ-UHFFFAOYSA-N 0.000 abstract 1
- 101100293593 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) nar-1 gene Proteins 0.000 abstract 1
- WTKZEGDFNFYCGP-UHFFFAOYSA-N Pyrazole Chemical compound C=1C=NNC=1 WTKZEGDFNFYCGP-UHFFFAOYSA-N 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- WBLIXGSTEMXDSM-UHFFFAOYSA-N chloromethane Chemical compound Cl[CH2] WBLIXGSTEMXDSM-UHFFFAOYSA-N 0.000 abstract 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- AWJUIBRHMBBTKR-UHFFFAOYSA-N iso-quinoline Natural products C1=NC=CC2=CC=CC=C21 AWJUIBRHMBBTKR-UHFFFAOYSA-N 0.000 abstract 1
- 125000002183 isoquinolinyl group Chemical class C1(=NC=CC2=CC=CC=C12)* 0.000 abstract 1
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 125000001624 naphthyl group Chemical group 0.000 abstract 1
- WCPAKWJPBJAGKN-UHFFFAOYSA-N oxadiazole Chemical compound C1=CON=N1 WCPAKWJPBJAGKN-UHFFFAOYSA-N 0.000 abstract 1
- 125000003854 p-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Cl 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 229940121649 protein inhibitor Drugs 0.000 abstract 1
- 239000012268 protein inhibitor Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 150000003536 tetrazoles Chemical class 0.000 abstract 1
- VLLMWSRANPNYQX-UHFFFAOYSA-N thiadiazole Chemical compound C1=CSN=N1.C1=CSN=N1 VLLMWSRANPNYQX-UHFFFAOYSA-N 0.000 abstract 1
- 150000003852 triazoles Chemical class 0.000 abstract 1
Classifications
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- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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2003
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- 2003-11-14 CL CL200302353A patent/CL2003002353A1/es unknown
- 2003-11-14 TW TW092132032A patent/TWI335913B/zh not_active IP Right Cessation
- 2003-11-17 ES ES03789812T patent/ES2318189T3/es not_active Expired - Lifetime
- 2003-11-17 DK DK03789812T patent/DK1562589T3/da active
- 2003-11-17 AT AT03789812T patent/ATE419849T1/de active
- 2003-11-17 KR KR1020057008795A patent/KR20060013480A/ko not_active Ceased
- 2003-11-17 EP EP03789812A patent/EP1562589B1/en not_active Expired - Lifetime
- 2003-11-17 DE DE60325761T patent/DE60325761D1/de not_active Expired - Lifetime
- 2003-11-17 US US10/715,111 patent/US7279469B2/en not_active Expired - Fee Related
- 2003-11-17 NZ NZ540662A patent/NZ540662A/en unknown
- 2003-11-17 SI SI200331537T patent/SI1562589T1/sl unknown
- 2003-11-17 WO PCT/US2003/036849 patent/WO2004046120A2/en not_active Ceased
- 2003-11-17 PL PL377825A patent/PL377825A1/pl not_active Application Discontinuation
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- 2003-11-17 AU AU2003294329A patent/AU2003294329B2/en not_active Ceased
- 2003-11-17 JP JP2004570619A patent/JP4783020B2/ja not_active Expired - Fee Related
- 2003-11-17 MX MXPA05005223A patent/MXPA05005223A/es unknown
- 2003-11-17 CA CA002505789A patent/CA2505789A1/en not_active Abandoned
- 2003-11-17 PT PT03789812T patent/PT1562589E/pt unknown
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| ATE419849T1 (de) | 2009-01-15 |
| AU2003294329A1 (en) | 2004-06-15 |
| US20040214817A1 (en) | 2004-10-28 |
| NZ540662A (en) | 2008-04-30 |
| JP2011132263A (ja) | 2011-07-07 |
| EP1562589B1 (en) | 2009-01-07 |
| DE60325761D1 (de) | 2009-02-26 |
| EP1562589A2 (en) | 2005-08-17 |
| DK1562589T3 (da) | 2009-02-16 |
| RU2350606C2 (ru) | 2009-03-27 |
| NO20052888D0 (no) | 2005-06-10 |
| KR20060013480A (ko) | 2006-02-10 |
| PL377825A1 (pl) | 2006-02-20 |
| PT1562589E (pt) | 2009-04-15 |
| CA2505789A1 (en) | 2004-06-03 |
| US7902239B2 (en) | 2011-03-08 |
| ES2318189T3 (es) | 2009-05-01 |
| JP4783020B2 (ja) | 2011-09-28 |
| RU2005118418A (ru) | 2006-02-10 |
| WO2004046120A3 (en) | 2004-08-12 |
| CL2003002353A1 (es) | 2005-02-04 |
| NO20052888L (no) | 2005-08-12 |
| JP2006515313A (ja) | 2006-05-25 |
| WO2004046120A2 (en) | 2004-06-03 |
| AU2003294329B2 (en) | 2010-04-29 |
| TW200413334A (en) | 2004-08-01 |
| TWI335913B (en) | 2011-01-11 |
| BR0316350A (pt) | 2005-09-27 |
| SI1562589T1 (sl) | 2009-06-30 |
| US7279469B2 (en) | 2007-10-09 |
| US20080014189A1 (en) | 2008-01-17 |
| MXPA05005223A (es) | 2010-09-07 |
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