BR0116792A - Derivados de diamina de triazol substituìdos como inibidores de quinase - Google Patents

Derivados de diamina de triazol substituìdos como inibidores de quinase

Info

Publication number
BR0116792A
BR0116792A BR0116792-8A BR0116792A BR0116792A BR 0116792 A BR0116792 A BR 0116792A BR 0116792 A BR0116792 A BR 0116792A BR 0116792 A BR0116792 A BR 0116792A
Authority
BR
Brazil
Prior art keywords
kinase inhibitors
substituted triazole
diamine derivatives
kinase
triazole diamine
Prior art date
Application number
BR0116792-8A
Other languages
English (en)
Inventor
Ronghui Lin
Peter J Connolly
Steven Wetter
Shenlin Huang
Stuart Emanual
Robert Guninger
Steve Middleton
Original Assignee
Ortho Mcneil Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ortho Mcneil Pharm Inc filed Critical Ortho Mcneil Pharm Inc
Publication of BR0116792A publication Critical patent/BR0116792A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D249/14—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

"DERIVADOS DE DIAMINA TRIAZOL SUBSTITUìDAS COMO INIBIDORES DE QUINASE". A presente invenção fornece derivados de diamina de triazol substituídos como inibidores de quinase seletiva ou de quinase dual e um método para tratar ou melhorar um distúrbio mediado por quinase seletiva ou quinase dual.
BR0116792-8A 2000-12-22 2001-12-21 Derivados de diamina de triazol substituìdos como inibidores de quinase BR0116792A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US25770300P 2000-12-22 2000-12-22
PCT/US2001/050559 WO2002057240A1 (en) 2000-12-22 2001-12-21 Substituted triazole diamine derivatives as kinase inhibitors

Publications (1)

Publication Number Publication Date
BR0116792A true BR0116792A (pt) 2004-02-17

Family

ID=22977396

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0116792-8A BR0116792A (pt) 2000-12-22 2001-12-21 Derivados de diamina de triazol substituìdos como inibidores de quinase

Country Status (24)

Country Link
US (2) US6924302B2 (pt)
EP (1) EP1355889B1 (pt)
CN (1) CN100357278C (pt)
AT (1) ATE328874T1 (pt)
BG (2) BG107959A (pt)
BR (1) BR0116792A (pt)
CA (1) CA2432870A1 (pt)
CZ (1) CZ20031941A3 (pt)
DE (1) DE60120494T2 (pt)
DK (1) DK1355889T3 (pt)
ES (1) ES2266313T3 (pt)
HK (1) HK1057373A1 (pt)
HU (1) HUP0303868A3 (pt)
IL (1) IL156584A0 (pt)
MX (1) MXPA03005777A (pt)
NO (1) NO20032848L (pt)
NZ (1) NZ526624A (pt)
PL (1) PL363316A1 (pt)
PT (1) PT1355889E (pt)
RU (1) RU2274639C2 (pt)
SK (1) SK9062003A3 (pt)
WO (1) WO2002057240A1 (pt)
YU (1) YU51803A (pt)
ZA (1) ZA200305619B (pt)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2378987T3 (es) * 2002-08-06 2012-04-19 Toray Industries, Inc. Remedio o agente preventivo para una enfermedad renal y procedimiento para diagnosticar una enfermedad renal
AR042052A1 (es) 2002-11-15 2005-06-08 Vertex Pharma Diaminotriazoles utiles como inhibidores de proteinquinasas
JP2007502327A (ja) 2003-05-13 2007-02-08 デピュイ スパイン、インコーポレイテッド 椎間板変性症の治療法
US7344716B2 (en) 2003-05-13 2008-03-18 Depuy Spine, Inc. Transdiscal administration of specific inhibitors of pro-inflammatory cytokines
US7553827B2 (en) 2003-08-13 2009-06-30 Depuy Spine, Inc. Transdiscal administration of cycline compounds
US8273347B2 (en) 2003-05-13 2012-09-25 Depuy Spine, Inc. Autologous treatment of degenerated disc with cells
US7429378B2 (en) 2003-05-13 2008-09-30 Depuy Spine, Inc. Transdiscal administration of high affinity anti-MMP inhibitors
US8361467B2 (en) 2003-07-30 2013-01-29 Depuy Spine, Inc. Trans-capsular administration of high specificity cytokine inhibitors into orthopedic joints
DE602004025258D1 (de) 2003-08-06 2010-03-11 Vertex Pharma Aminotriazol-verbindungen als proteinkinase-hemmer
US8895540B2 (en) 2003-11-26 2014-11-25 DePuy Synthes Products, LLC Local intraosseous administration of bone forming agents and anti-resorptive agents, and devices therefor
DE10356579A1 (de) * 2003-12-04 2005-07-07 Merck Patent Gmbh Aminderivate
US20090270456A1 (en) * 2004-01-09 2009-10-29 Masaichi Hasegawa Novel chemical compounds
EP1725295B1 (en) 2004-01-21 2010-09-15 Emory University Compositions and use of tyrosine kinase inhibitors to treat pathogenic infection
KR20070036025A (ko) * 2004-02-11 2007-04-02 얀센 파마슈티카 엔.브이. 치환된 트리아졸 화합물의 제조방법
WO2006042215A1 (en) * 2004-10-08 2006-04-20 Janssen Pharmaceutica, N.V. 1,2,4-triazolylaminoaryl (heteroaryl) sulfonamide derivatives
ZA200703950B (en) 2004-10-21 2008-07-30 Vertex Pharma Triazoles useful as inhibitors of protein kinases
DE102004055998A1 (de) 2004-11-19 2006-05-24 Rheinische Friedrich-Wilhelms-Universität Bonn Niedermolekulare Inhibitoren von Guaninnucleotid-Austauschfaktoren der Cytohesin-Familie
ES2552338T3 (es) 2005-01-21 2015-11-27 Astex Therapeutics Limited Compuestos farmacéuticos
EP1922310A2 (en) * 2005-09-07 2008-05-21 Rigel Pharmaceuticals, Inc. Triazole derivatives useful as axl inhibitors
US7879887B2 (en) 2006-06-29 2011-02-01 Nissan Chemical Industries, Ltd. α-amino acid derivatives and medicaments containing the same as an active ingredient
JP5528806B2 (ja) 2006-10-12 2014-06-25 アステックス、セラピューティックス、リミテッド 複合薬剤
JP5528807B2 (ja) 2006-10-12 2014-06-25 アステックス、セラピューティックス、リミテッド 複合薬剤
DE102006054205A1 (de) * 2006-11-15 2008-05-29 Rheinische Friedrich-Wilhelms Universität Verwendung von Cytohesin-Inhibitoren zur chemischen Induktion von Langlebigkeit
EP2139852A1 (en) 2006-12-19 2010-01-06 Pharmos Corporation Sulfonamide derivatives with therapeutic indications
EP2476679B1 (en) 2006-12-29 2015-10-14 Rigel Pharmaceuticals, Inc. Substituted triazoles useful as AXL inhibitors
WO2008083367A2 (en) 2006-12-29 2008-07-10 Rigel Pharmaceuticals, Inc. Polycyclic heteroaryl substituted triazoles useful as axl inhibitors
WO2008083353A1 (en) * 2006-12-29 2008-07-10 Rigel Pharmaceuticals, Inc. Bicyclic aryl and bicyclic heteroaryl substituted triazoles useful as axl inhibitors
DK2114955T3 (da) 2006-12-29 2013-05-06 Rigel Pharmaceuticals Inc Broforbundet, bicyklisk aryl og broforbundet, bicyklisk heteroaryl subsitiuerede triazoler, der er anvendelige som axl-inhibitorer
ES2672172T3 (es) 2006-12-29 2018-06-12 Rigel Pharmaceuticals, Inc. Triazoles N3-heteroarilsustituidos y triazoles N5-heteroarilsustituidos útiles como inhibidores de Axl
JO2784B1 (en) 2007-10-18 2014-03-15 شركة جانسين فارماسوتيكا ان. في 5,3,1 - Triazole substitute derivative
RU2474579C2 (ru) * 2007-10-18 2013-02-10 Янссен Фармацевтика Нв Тризамещенные 1,2,4-триазолы
US7935693B2 (en) * 2007-10-26 2011-05-03 Rigel Pharmaceuticals, Inc. Polycyclic aryl substituted triazoles and polycyclic heteroaryl substituted triazoles useful as Axl inhibitors
US8986696B2 (en) 2007-12-21 2015-03-24 Depuy Mitek, Inc. Trans-capsular administration of p38 map kinase inhibitors into orthopedic joints
CA2713716A1 (en) 2008-02-22 2009-08-27 F. Hoffmann-La Roche Ag Modulators for amyloid beta
CN102066343B (zh) 2008-03-19 2013-12-04 詹森药业有限公司 作为烟碱乙酰胆碱受体调节剂的三取代1，2，4-三唑类
JP5486591B2 (ja) 2008-05-09 2014-05-07 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ アセチルコリン受容体モジュレーターとしての三置換ピラゾール
US8431594B2 (en) 2008-07-09 2013-04-30 Rigel Pharmaceuticals, Inc. Bridged bicyclic heteroaryl substituted triazoles useful as AXL inhibitors
ES2537480T3 (es) 2008-07-09 2015-06-08 Rigel Pharmaceuticals, Inc. Triazoles sustituidos con heteroarilo policíclicos útiles como inhibidores de Axl
MX2011003246A (es) 2008-10-09 2011-04-21 Hoffmann La Roche Moduladores de beta amiloide.
JP5378532B2 (ja) 2008-11-10 2013-12-25 エフ．ホフマン−ラ ロシュ アーゲー 複素環γ−セクレターゼモジュレーター
PL2387395T3 (pl) 2009-01-16 2015-03-31 Rigel Pharmaceuticals Inc Inhibitory Axl do zastosowania w terapii skojarzonej do zapobiegania, leczenia lub postępowania z nowotworem przerzutowym
US8486967B2 (en) 2010-02-17 2013-07-16 Hoffmann-La Roche Inc. Heteroaryl substituted piperidines
US20140010783A1 (en) * 2012-07-06 2014-01-09 Hoffmann-La Roche Inc. Antiviral compounds
JP6293770B2 (ja) 2012-11-05 2018-03-14 ナント ホールディングス アイピー，エルエルシー ヘッジホッグシグナル伝達経路阻害剤としての環状スルホンアミド含有誘導体
JP6093456B2 (ja) * 2013-03-05 2017-03-08 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 抗ウイルス性化合物
US9693997B2 (en) * 2013-03-06 2017-07-04 Hoffmann-La Roche Inc. Antiviral compounds
WO2018175670A1 (en) 2017-03-22 2018-09-27 The Research Foundation For The State University Of New York Matrix metalloproteinase-9 hemopexin domain inhibitors and methods of treatment using same
US20220112166A1 (en) * 2020-10-13 2022-04-14 Yale University Selective JAK2 Pseudokinase Ligands and Methods of Use
KR20240093844A (ko) * 2021-10-26 2024-06-24 바소카데아, 인코포레이티드 Gpr39 단백질의 길항제
CN114292243B (zh) * 2022-01-12 2023-11-21 中山大学 一种三唑类衍生物或其药学上可接受的盐及其制备方法和应用

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2352944A (en) 1942-07-04 1944-07-04 Gen Electric Triazole derivatives
NL301383A (pt) * 1962-12-06
US4727022A (en) * 1984-03-14 1988-02-23 Syntex (U.S.A.) Inc. Methods for modulating ligand-receptor interactions and their application
US5196351A (en) * 1987-09-30 1993-03-23 Beckman Instruments, Inc. Bidentate conjugate and method of use thereof
US5683867A (en) * 1990-06-11 1997-11-04 Nexstar Pharmaceuticals, Inc. Systematic evolution of ligands by exponential enrichment: blended SELEX
ATE269401T1 (de) * 1991-04-10 2004-07-15 Scripps Research Inst Bibliotheken heterodimerer rezeptoren mittels phagemiden
ES2139605T3 (es) * 1991-09-02 2000-02-16 Yamanouchi Pharma Co Ltd Amina terciaria triazolilada o una sal de esta.
US5543507A (en) * 1992-03-05 1996-08-06 Isis Pharmaceuticals, Inc. Covalently cross-linked oligonucleotides
US5362859A (en) * 1992-07-27 1994-11-08 Sepracor, Inc. High-capacity affinity supports and methods for the preparation and use of same
US5512435A (en) * 1993-02-05 1996-04-30 Renschler; Markus F. Receptor-binding antiproliferative peptides
EP0710654A4 (en) * 1993-07-23 1996-08-28 Green Cross Corp TRIAZOLE DERIVATIVE AND ITS PHARMACEUTICAL USE
US5698401A (en) * 1995-11-14 1997-12-16 Abbott Laboratories Use of nuclear magnetic resonance to identify ligands to target biomolecules
ATE315553T1 (de) * 1997-10-27 2006-02-15 Agouron Pharma 4-aminothiazol derivate, deren herstellung und deren verwendung als inhibitoren cyclin- abhängiger kinasen
GB9918180D0 (en) * 1999-08-02 1999-10-06 Smithkline Beecham Plc Novel compositions

Also Published As

Publication number Publication date
DE60120494T2 (de) 2006-12-21
EP1355889B1 (en) 2006-06-07
ES2266313T3 (es) 2007-03-01
ZA200305619B (en) 2004-10-21
US6924302B2 (en) 2005-08-02
NZ526624A (en) 2005-07-29
YU51803A (sh) 2006-05-25
HUP0303868A3 (en) 2008-03-28
IL156584A0 (en) 2004-01-04
WO2002057240A1 (en) 2002-07-25
RU2274639C2 (ru) 2006-04-20
SK9062003A3 (en) 2004-04-06
NO20032848D0 (no) 2003-06-20
PT1355889E (pt) 2006-09-29
BG107959A (bg) 2004-12-30
NO20032848L (no) 2003-08-20
MXPA03005777A (es) 2005-02-14
RU2003118448A (ru) 2005-01-27
CA2432870A1 (en) 2002-07-25
CN1575284A (zh) 2005-02-02
EP1355889A1 (en) 2003-10-29
BG107985A (bg) 2004-11-30
US20050182116A1 (en) 2005-08-18
ATE328874T1 (de) 2006-06-15
DK1355889T3 (da) 2006-10-09
DE60120494D1 (de) 2006-07-20
CN100357278C (zh) 2007-12-26
CZ20031941A3 (cs) 2004-08-18
PL363316A1 (en) 2004-11-15
HK1057373A1 (en) 2004-04-02
US7317031B2 (en) 2008-01-08
HUP0303868A2 (hu) 2004-03-01
US20040077699A1 (en) 2004-04-22

Similar Documents

Publication Publication Date Title
BR0116792A (pt) Derivados de diamina de triazol substituìdos como inibidores de quinase
CY1117951T1 (el) Αναστολεiς κινασης υποκατεστημενης τριαζινης
IL139080A0 (en) Btx inhibitors and methods for their indentification and use
IL147618A0 (en) Method for treating chronic pain using mek inhibitors
BRPI0412918A (pt) inibidores de quinases p38
PT1143967E (pt) Utilizacao de derivados anticonvulsivos para o tratamento de cefaleias em salvas
WO2001044247A3 (en) Agents and methods for the treatment of proliferative diseases
AU2737102A (en) Macroheterocylic compounds useful as kinase inhibitors
HK1155944A1 (en) W-carboxy aryl substituted diphenyl ureas as p38 kinase inhibitors
IL144643A0 (en) Jak-3 inhibitors for treating allergic disorders
WO2001005391A3 (en) Method for treating chronic pain using mek inhibitors
BR0017157A (pt) Derivados de 6-hidroxi-indazol para o tratamento de glaucoma
WO2001096547A3 (en) Human kinases
WO2001087287A3 (en) Use of pyrazole derivatives for treating infertility
MXPA03006607A (es) Metodo combinado para tratar trastornos dependientes de hormonas.
MXPA03001484A (es) Quinazolinas, medicamentos que contienen estos compuestos, y son efectivos como inhbidores de tirosina quinasa, su utilizacion y metodos para su produccion.
WO2002083151A3 (en) Compositions and methods for treating an arthritic condition
WO2001044235A3 (en) Agents and methods for the treatment of proliferative diseases
PT1212119E (pt) Utilizacao de ciamemazina no tratamento do desmame subito de benzodiazepinas
IL139144A0 (en) Mycobacterial inhibitors
YU51802A (sh) Nova terapeutska primena enoksaparina
ZA200307471B (en) Carbamate compounds for use in preventing or treating bipolar disorder.
UA32314A (uk) Спосіб лікування некротичного панкреатиту

Legal Events

Date Code Title Description
B25A Requested transfer of rights approved

Owner name: JOHNSON AND JOHNSON (US)

Free format text: TRANSFERIDO DE: ORTHO-MCNEIL PHARMACEUTICAL, INC.

B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE 7A. E 8A. ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 DA RPI 2021 DE 29/09/2009.