HUP0303868A3 - Substituted triazole diamine derivatives as kinase inhibitors and their use for preparation of pharmaceutical compositions - Google Patents

Substituted triazole diamine derivatives as kinase inhibitors and their use for preparation of pharmaceutical compositions

Info

Publication number
HUP0303868A3
HUP0303868A3 HU0303868A HUP0303868A HUP0303868A3 HU P0303868 A3 HUP0303868 A3 HU P0303868A3 HU 0303868 A HU0303868 A HU 0303868A HU P0303868 A HUP0303868 A HU P0303868A HU P0303868 A3 HUP0303868 A3 HU P0303868A3
Authority
HU
Hungary
Prior art keywords
preparation
pharmaceutical compositions
kinase inhibitors
substituted triazole
diamine derivatives
Prior art date
Application number
HU0303868A
Other languages
English (en)
Original Assignee
Ortho Mcneil Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ortho Mcneil Pharm Inc filed Critical Ortho Mcneil Pharm Inc
Publication of HUP0303868A2 publication Critical patent/HUP0303868A2/hu
Publication of HUP0303868A3 publication Critical patent/HUP0303868A3/hu

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/41641,3-Diazoles
    • A61K31/41781,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/41961,2,4-Triazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425Thiazoles
    • A61K31/427Thiazoles not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D249/00Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/081,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/101,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D249/14Nitrogen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
HU0303868A 2000-12-22 2001-12-21 Substituted triazole diamine derivatives as kinase inhibitors and their use for preparation of pharmaceutical compositions HUP0303868A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US25770300P 2000-12-22 2000-12-22
PCT/US2001/050559 WO2002057240A1 (en) 2000-12-22 2001-12-21 Substituted triazole diamine derivatives as kinase inhibitors

Publications (2)

Publication Number Publication Date
HUP0303868A2 HUP0303868A2 (hu) 2004-03-01
HUP0303868A3 true HUP0303868A3 (en) 2008-03-28

Family

ID=22977396

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0303868A HUP0303868A3 (en) 2000-12-22 2001-12-21 Substituted triazole diamine derivatives as kinase inhibitors and their use for preparation of pharmaceutical compositions

Country Status (24)

Country Link
US (2) US6924302B2 (hu)
EP (1) EP1355889B1 (hu)
CN (1) CN100357278C (hu)
AT (1) ATE328874T1 (hu)
BG (2) BG107959A (hu)
BR (1) BR0116792A (hu)
CA (1) CA2432870A1 (hu)
CZ (1) CZ20031941A3 (hu)
DE (1) DE60120494T2 (hu)
DK (1) DK1355889T3 (hu)
ES (1) ES2266313T3 (hu)
HK (1) HK1057373A1 (hu)
HU (1) HUP0303868A3 (hu)
IL (1) IL156584A0 (hu)
MX (1) MXPA03005777A (hu)
NO (1) NO20032848L (hu)
NZ (1) NZ526624A (hu)
PL (1) PL363316A1 (hu)
PT (1) PT1355889E (hu)
RU (1) RU2274639C2 (hu)
SK (1) SK9062003A3 (hu)
WO (1) WO2002057240A1 (hu)
YU (1) YU51803A (hu)
ZA (1) ZA200305619B (hu)

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EA200700818A1 (ru) * 2004-10-08 2007-08-31 Янссен Фармацевтика, Н.В. Производные 1,2,4-триазолиламиноарил(гетероарил)сульфонамидов
ES2352453T3 (es) * 2004-10-21 2011-02-18 Vertex Pharmaceuticals Incorporated Triazoles útiles como inhibidores de proteínas quinasas.
DE102004055998A1 (de) 2004-11-19 2006-05-24 Rheinische Friedrich-Wilhelms-Universität Bonn Niedermolekulare Inhibitoren von Guaninnucleotid-Austauschfaktoren der Cytohesin-Familie
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ES2460894T3 (es) 2006-12-29 2014-05-14 Rigel Pharmaceuticals, Inc. Triazoles sustituidos con heteroarilo policíclico útiles como inhibidores de Axl
ES2404668T3 (es) 2006-12-29 2013-05-28 Rigel Pharmaceuticals, Inc. Triazoles sustituidos con arilo bicíclico puenteado y heteroarilo bicíclico puenteado, útiles como agentes inhibidores del axl
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Also Published As

Publication number Publication date
PT1355889E (pt) 2006-09-29
ES2266313T3 (es) 2007-03-01
DK1355889T3 (da) 2006-10-09
CA2432870A1 (en) 2002-07-25
NO20032848D0 (no) 2003-06-20
BG107985A (bg) 2004-11-30
DE60120494T2 (de) 2006-12-21
NO20032848L (no) 2003-08-20
DE60120494D1 (de) 2006-07-20
YU51803A (sh) 2006-05-25
US6924302B2 (en) 2005-08-02
CZ20031941A3 (cs) 2004-08-18
US20050182116A1 (en) 2005-08-18
US20040077699A1 (en) 2004-04-22
RU2274639C2 (ru) 2006-04-20
SK9062003A3 (en) 2004-04-06
CN1575284A (zh) 2005-02-02
BR0116792A (pt) 2004-02-17
HK1057373A1 (en) 2004-04-02
US7317031B2 (en) 2008-01-08
WO2002057240A1 (en) 2002-07-25
EP1355889B1 (en) 2006-06-07
RU2003118448A (ru) 2005-01-27
MXPA03005777A (es) 2005-02-14
HUP0303868A2 (hu) 2004-03-01
NZ526624A (en) 2005-07-29
IL156584A0 (en) 2004-01-04
EP1355889A1 (en) 2003-10-29
ATE328874T1 (de) 2006-06-15
ZA200305619B (en) 2004-10-21
CN100357278C (zh) 2007-12-26
PL363316A1 (en) 2004-11-15
BG107959A (bg) 2004-12-30

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