BRPI0412918A - inibidores de quinases p38 - Google Patents

inibidores de quinases p38

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Publication number
BRPI0412918A
BRPI0412918A BRPI0412918-0A BRPI0412918A BRPI0412918A BR PI0412918 A BRPI0412918 A BR PI0412918A BR PI0412918 A BRPI0412918 A BR PI0412918A BR PI0412918 A BRPI0412918 A BR PI0412918A
Authority
BR
Brazil
Prior art keywords
kinase inhibitors
kinase
ameliorating
kinases
modulating
Prior art date
Application number
BRPI0412918-0A
Other languages
English (en)
Inventor
Hengyuan Lang
Jiong Lan
Yunfeng Fang
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of BRPI0412918A publication Critical patent/BRPI0412918A/pt

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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/538—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with carbocyclic ring systems
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4245—Oxadiazoles
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • A61K31/4965—Non-condensed pyrazines
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Abstract

"INIBIDORES DE QUINASES p38". A presente invenção refere-se a compostos e composições para modular a atividade de quinases p38, incluindo as quinases p38<244> e p38<225>. São fornecidos também métodos para tratar, prevenir ou melhorar um ou mais sintomas de uma doença ou distúrbio mediado por quinases p38.
BRPI0412918-0A 2003-07-25 2004-07-23 inibidores de quinases p38 BRPI0412918A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US49009603P 2003-07-25 2003-07-25
PCT/US2004/023726 WO2005012241A2 (en) 2003-07-25 2004-07-23 p-38 KINASE INHIBITORS

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BRPI0412918A true BRPI0412918A (pt) 2006-09-26

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EP (3) EP2251333A1 (pt)
JP (1) JP2007500129A (pt)
CN (2) CN100447137C (pt)
AT (2) ATE412642T1 (pt)
AU (2) AU2004261589B2 (pt)
BR (1) BRPI0412918A (pt)
CA (1) CA2534990A1 (pt)
DE (2) DE602004029293D1 (pt)
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PL (1) PL1687284T3 (pt)
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CN111183957A (zh) * 2020-02-19 2020-05-22 中国医科大学附属第一医院 一种减轻自身免疫甲状腺炎模型的构建方法及其应用
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KR102298450B1 (ko) * 2021-01-29 2021-09-08 (주)프레이저테라퓨틱스 p38 MAP 키나아제 억제제로 항염증 활성을 나타내는 신규 화합물
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US7700622B2 (en) 2010-04-20
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CN100447137C (zh) 2008-12-31
WO2005012241A3 (en) 2005-04-14
ES2315703T3 (es) 2009-04-01
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WO2005012241A2 (en) 2005-02-10
EP1990338A2 (en) 2008-11-12
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US7754726B2 (en) 2010-07-13
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US20100234404A1 (en) 2010-09-16
EP1687284A2 (en) 2006-08-09
MXPA06000915A (es) 2006-03-30
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PT1687284E (pt) 2009-01-30
AU2004261589B2 (en) 2008-05-22
JP2007500129A (ja) 2007-01-11
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