JP2016040262A5 - - Google Patents
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- Publication number
- JP2016040262A5 JP2016040262A5 JP2015182722A JP2015182722A JP2016040262A5 JP 2016040262 A5 JP2016040262 A5 JP 2016040262A5 JP 2015182722 A JP2015182722 A JP 2015182722A JP 2015182722 A JP2015182722 A JP 2015182722A JP 2016040262 A5 JP2016040262 A5 JP 2016040262A5
- Authority
- JP
- Japan
- Prior art keywords
- alkoxy
- alkyl
- optionally substituted
- hydroxy
- substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000003545 alkoxy group Chemical group 0.000 claims 194
- 125000000217 alkyl group Chemical group 0.000 claims 133
- 125000005843 halogen group Chemical group 0.000 claims 75
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 73
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 33
- 150000003839 salts Chemical class 0.000 claims 28
- 125000000304 alkynyl group Chemical group 0.000 claims 27
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 26
- 239000012453 solvate Substances 0.000 claims 26
- 125000001424 substituent group Chemical group 0.000 claims 25
- 150000001875 compounds Chemical class 0.000 claims 24
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 24
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 23
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 23
- -1 cyano, carboxy Chemical group 0.000 claims 22
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 claims 21
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 15
- 125000004414 alkyl thio group Chemical group 0.000 claims 15
- 125000004093 cyano group Chemical group *C#N 0.000 claims 13
- 125000004076 pyridyl group Chemical group 0.000 claims 13
- 229910052757 nitrogen Inorganic materials 0.000 claims 12
- 125000004043 oxo group Chemical group O=* 0.000 claims 12
- 125000003118 aryl group Chemical group 0.000 claims 8
- 229910052799 carbon Inorganic materials 0.000 claims 8
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 8
- 125000006570 (C5-C6) heteroaryl group Chemical group 0.000 claims 7
- 125000000714 pyrimidinyl group Chemical group 0.000 claims 7
- 125000001313 C5-C10 heteroaryl group Chemical group 0.000 claims 6
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 6
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 5
- 229920006395 saturated elastomer Polymers 0.000 claims 5
- 150000001721 carbon Chemical group 0.000 claims 4
- 125000001072 heteroaryl group Chemical group 0.000 claims 4
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 4
- 125000000719 pyrrolidinyl group Chemical group 0.000 claims 4
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 claims 3
- 125000006584 (C3-C10) heterocycloalkyl group Chemical group 0.000 claims 3
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 3
- 125000000623 heterocyclic group Chemical group 0.000 claims 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 3
- 125000002757 morpholinyl group Chemical group 0.000 claims 3
- 125000000168 pyrrolyl group Chemical group 0.000 claims 3
- 125000006274 (C1-C3)alkoxy group Chemical group 0.000 claims 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 2
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 claims 2
- 125000001376 1,2,4-triazolyl group Chemical group N1N=C(N=C1)* 0.000 claims 2
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 claims 2
- 125000003566 oxetanyl group Chemical group 0.000 claims 2
- 125000006698 (C1-C3) dialkylamino group Chemical group 0.000 claims 1
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 claims 1
- CCBKKKYZCOBIJN-UHFFFAOYSA-N 7-[[2,3-difluoro-4-[2-[2-methoxyethyl(methyl)amino]ethoxy]phenyl]methyl]-10-hydroxy-6-methyl-8-oxo-n-[4-(trifluoromethyl)-2-[6-(trifluoromethyl)pyrimidin-4-yl]phenyl]-6,7-diazaspiro[4.5]dec-9-ene-9-carboxamide Chemical compound FC1=C(F)C(OCCN(C)CCOC)=CC=C1CN1C(=O)C(C(=O)NC=2C(=CC(=CC=2)C(F)(F)F)C=2N=CN=C(C=2)C(F)(F)F)=C(O)C2(CCCC2)N1C CCBKKKYZCOBIJN-UHFFFAOYSA-N 0.000 claims 1
- 125000006374 C2-C10 alkenyl group Chemical group 0.000 claims 1
- 125000004649 C2-C8 alkynyl group Chemical group 0.000 claims 1
- 125000003342 alkenyl group Chemical group 0.000 claims 1
- 125000002947 alkylene group Chemical group 0.000 claims 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 1
- 125000000000 cycloalkoxy group Chemical group 0.000 claims 1
- 125000000753 cycloalkyl group Chemical group 0.000 claims 1
- 125000005842 heteroatom Chemical group 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 125000006413 ring segment Chemical group 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2015182722A JP6420738B2 (ja) | 2013-03-13 | 2015-09-16 | ジヒドロピリダジン−３，５−ジオン誘導体 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2013051082 | 2013-03-13 | ||
| JP2013051082 | 2013-03-13 | ||
| JP2013132889 | 2013-06-25 | ||
| JP2013132889 | 2013-06-25 | ||
| JP2015182722A JP6420738B2 (ja) | 2013-03-13 | 2015-09-16 | ジヒドロピリダジン−３，５−ジオン誘導体 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015505576A Division JP5814488B2 (ja) | 2013-03-13 | 2014-03-13 | ジヒドロピリダジン−３，５−ジオン誘導体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016040262A JP2016040262A (ja) | 2016-03-24 |
| JP2016040262A5 true JP2016040262A5 (enExample) | 2017-04-27 |
| JP6420738B2 JP6420738B2 (ja) | 2018-11-07 |
Family
ID=51536921
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015505576A Active JP5814488B2 (ja) | 2013-03-13 | 2014-03-13 | ジヒドロピリダジン−３，５−ジオン誘導体 |
| JP2015182722A Active JP6420738B2 (ja) | 2013-03-13 | 2015-09-16 | ジヒドロピリダジン−３，５−ジオン誘導体 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015505576A Active JP5814488B2 (ja) | 2013-03-13 | 2014-03-13 | ジヒドロピリダジン−３，５−ジオン誘導体 |
Country Status (29)
| Country | Link |
|---|---|
| EP (2) | EP2975030B1 (enExample) |
| JP (2) | JP5814488B2 (enExample) |
| KR (2) | KR102072268B1 (enExample) |
| CN (1) | CN105073715B (enExample) |
| AU (1) | AU2014230552B2 (enExample) |
| BR (1) | BR112015022092B1 (enExample) |
| CA (1) | CA2901868C (enExample) |
| CL (1) | CL2015002543A1 (enExample) |
| CR (1) | CR20150505A (enExample) |
| DK (1) | DK2975030T3 (enExample) |
| ES (1) | ES2811126T3 (enExample) |
| HR (1) | HRP20201211T1 (enExample) |
| HU (1) | HUE050577T2 (enExample) |
| IL (1) | IL240825B (enExample) |
| LT (1) | LT2975030T (enExample) |
| MX (1) | MX376532B (enExample) |
| MY (1) | MY174269A (enExample) |
| NZ (1) | NZ711182A (enExample) |
| PE (1) | PE20151535A1 (enExample) |
| PH (1) | PH12015501940A1 (enExample) |
| PL (1) | PL2975030T3 (enExample) |
| PT (1) | PT2975030T (enExample) |
| RS (1) | RS60911B1 (enExample) |
| RU (1) | RU2662832C2 (enExample) |
| SG (1) | SG11201507345RA (enExample) |
| SI (1) | SI2975030T1 (enExample) |
| TW (2) | TWI596095B (enExample) |
| UA (1) | UA118755C2 (enExample) |
| WO (1) | WO2014142273A1 (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUE050577T2 (hu) * | 2013-03-13 | 2020-12-28 | Chugai Pharmaceutical Co Ltd | Dihidropiridazin-3,5-dion-származék |
| CN107072993B (zh) * | 2014-09-12 | 2021-02-12 | 中外制药株式会社 | 含有钠依赖性磷酸转运蛋白抑制剂的药物 |
| WO2018019755A1 (en) | 2016-07-26 | 2018-02-01 | Basf Se | Herbicidal pyridine compounds |
| WO2018019721A1 (en) | 2016-07-26 | 2018-02-01 | Basf Se | Herbicidal pyridine compounds |
| CN110885290A (zh) * | 2019-12-16 | 2020-03-17 | 阿里生物新材料（常州）有限公司 | 一种3-氟-2-甲基-4-三氟甲基苯胺盐酸盐的合成方法 |
| CA3186902A1 (en) | 2020-06-26 | 2021-12-30 | Nihon Nohyaku Co., Ltd. | Aryltetrahydropyridazine derivative or salt thereof, insecticidal agent containing the compound, and method of use thereof |
| WO2022221182A1 (en) * | 2021-04-12 | 2022-10-20 | Jnana Therapeutics Inc. | Small molecule inhibitors of mammalian slc34a1 function |
| JPWO2022260064A1 (enExample) | 2021-06-08 | 2022-12-15 | ||
| AR126060A1 (es) | 2021-06-08 | 2023-09-06 | Chugai Pharmaceutical Co Ltd | Método para producir derivado de dihidropiridazin-3,5-diona |
| KR20240125659A (ko) | 2021-12-28 | 2024-08-19 | 니혼노야쿠가부시키가이샤 | 아릴테트라히드로피리다진 유도체 또는 그의 염류 및 해당 화합물을 함유하는 살충제 그리고 그 사용 방법 |
| CN119212723A (zh) | 2022-05-11 | 2024-12-27 | 中外制药株式会社 | 用于治疗或预防囊性疾病的药物组合物 |
| CN116217862A (zh) * | 2023-03-21 | 2023-06-06 | 中国农业科学院农业环境与可持续发展研究所 | 一种可降解生物膜助剂的制备方法 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1477175B1 (en) * | 2002-02-19 | 2011-04-27 | Ono Pharmaceutical Co., Ltd. | Fused pyridazine derivative compounds and drugs containing the compounds as the active ingredient |
| CN1662529A (zh) * | 2002-06-19 | 2005-08-31 | 默克专利有限公司 | 作为磷酸二酯酶iv抑制剂的噻唑衍生物 |
| EP1967516B1 (en) * | 2005-05-18 | 2009-11-04 | Array Biopharma, Inc. | 4-(phenylamino)-6-oxo-1,6-dihydropyridazine-3-carboxamide derivatives as MEK inhibitors for the treatment of hyperproliferative diseases |
| GB0610680D0 (en) * | 2006-05-31 | 2006-07-12 | Istituto Di Ricerche D Biolog | Therapeutic compounds |
| EP2086944B1 (de) * | 2006-11-03 | 2010-01-13 | Basf Se | Verfahren zur herstellung von difluormethylpyrazolylcarboxylaten |
| TW201006821A (en) * | 2008-07-16 | 2010-02-16 | Bristol Myers Squibb Co | Pyridone and pyridazone analogues as GPR119 modulators |
| EP2334682B1 (en) * | 2008-08-20 | 2017-10-04 | Fibrogen, Inc. | Pyrrolo [ 1, 2 -b] pyridazine derivatives and their use as hif modulators |
| WO2011048611A1 (en) * | 2009-10-07 | 2011-04-28 | Torrent Pharmaceuticals Limited | Novel fused pyridazine derivatives |
| US20130029973A1 (en) | 2010-04-28 | 2013-01-31 | Astellas Pharma Inc. | Tetrahydrobenzothiophene compound |
| EP2591354B1 (en) | 2010-07-07 | 2016-09-07 | Ardelyx, Inc. | Compounds and methods for inhibiting phosphate transport |
| WO2012006474A2 (en) * | 2010-07-07 | 2012-01-12 | Ardelyx, Inc. | Compounds and methods for inhibiting phosphate transport |
| CA2853688C (en) | 2011-10-27 | 2018-06-12 | Astellas Pharma Inc. | Aminoalkyl-substituted n-thienylbenzamide derivative |
| HUE050577T2 (hu) * | 2013-03-13 | 2020-12-28 | Chugai Pharmaceutical Co Ltd | Dihidropiridazin-3,5-dion-származék |
-
2014
- 2014-03-13 HU HUE14765619A patent/HUE050577T2/hu unknown
- 2014-03-13 EP EP14765619.3A patent/EP2975030B1/en active Active
- 2014-03-13 DK DK14765619.3T patent/DK2975030T3/da active
- 2014-03-13 CN CN201480013485.6A patent/CN105073715B/zh active Active
- 2014-03-13 EP EP20185235.7A patent/EP3757093A1/en active Pending
- 2014-03-13 KR KR1020167027514A patent/KR102072268B1/ko active Active
- 2014-03-13 MX MX2015012537A patent/MX376532B/es active IP Right Grant
- 2014-03-13 PL PL14765619T patent/PL2975030T3/pl unknown
- 2014-03-13 RS RS20201171A patent/RS60911B1/sr unknown
- 2014-03-13 MY MYPI2015703054A patent/MY174269A/en unknown
- 2014-03-13 SG SG11201507345RA patent/SG11201507345RA/en unknown
- 2014-03-13 AU AU2014230552A patent/AU2014230552B2/en active Active
- 2014-03-13 HR HRP20201211TT patent/HRP20201211T1/hr unknown
- 2014-03-13 RU RU2015143507A patent/RU2662832C2/ru active
- 2014-03-13 SI SI201431629T patent/SI2975030T1/sl unknown
- 2014-03-13 ES ES14765619T patent/ES2811126T3/es active Active
- 2014-03-13 UA UAA201509770A patent/UA118755C2/uk unknown
- 2014-03-13 PE PE2015001917A patent/PE20151535A1/es unknown
- 2014-03-13 LT LTEP14765619.3T patent/LT2975030T/lt unknown
- 2014-03-13 TW TW103109058A patent/TWI596095B/zh active
- 2014-03-13 PT PT147656193T patent/PT2975030T/pt unknown
- 2014-03-13 CA CA2901868A patent/CA2901868C/en active Active
- 2014-03-13 JP JP2015505576A patent/JP5814488B2/ja active Active
- 2014-03-13 TW TW106123450A patent/TWI683811B/zh active
- 2014-03-13 BR BR112015022092-4A patent/BR112015022092B1/pt active IP Right Grant
- 2014-03-13 KR KR1020157029079A patent/KR101664460B1/ko active Active
- 2014-03-13 WO PCT/JP2014/056778 patent/WO2014142273A1/ja not_active Ceased
- 2014-03-13 NZ NZ711182A patent/NZ711182A/en unknown
-
2015
- 2015-08-25 IL IL240825A patent/IL240825B/en active IP Right Grant
- 2015-09-03 PH PH12015501940A patent/PH12015501940A1/en unknown
- 2015-09-09 CL CL2015002543A patent/CL2015002543A1/es unknown
- 2015-09-16 JP JP2015182722A patent/JP6420738B2/ja active Active
- 2015-09-22 CR CR20150505A patent/CR20150505A/es unknown
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