SG11201507345RA - Dihydropyridazine-3,5-dione derivative - Google Patents

Dihydropyridazine-3,5-dione derivative

Info

Publication number
SG11201507345RA
SG11201507345RA SG11201507345RA SG11201507345RA SG11201507345RA SG 11201507345R A SG11201507345R A SG 11201507345RA SG 11201507345R A SG11201507345R A SG 11201507345RA SG 11201507345R A SG11201507345R A SG 11201507345RA SG 11201507345R A SG11201507345R A SG 11201507345RA
Authority
SG
Singapore
Prior art keywords
dihydropyridazine
dione derivative
dione
derivative
Prior art date
Application number
SG11201507345RA
Inventor
Yoshihito Ohtake
Naoki Okamoto
Yoshiyuki Ono
Hirotaka Kashiwagi
Atsushi Kimbara
Takeo Harada
Nobuyuki Hori
Yoshihisa Murata
Kazutaka Tachibana
Shota Tanaka
Kenichi Nomura
Mitsuaki Ide
Eisaku Mizuguchi
Yasuhiro Ichida
Shuichi Ohtomo
Naoshi Horiba
Original Assignee
Chugai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd
Publication of SG11201507345RA publication Critical patent/SG11201507345RA/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D237/00Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/04Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having less than three double bonds between ring members or between ring members and non-ring members
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50Pyridazines; Hydrogenated pyridazines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50Pyridazines; Hydrogenated pyridazines
    • A61K31/501Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50Pyridazines; Hydrogenated pyridazines
    • A61K31/5025Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50Pyridazines; Hydrogenated pyridazines
    • A61K31/504Pyridazines; Hydrogenated pyridazines forming part of bridged ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/53751,4-Oxazines, e.g. morpholine
    • A61K31/53771,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/12Drugs for disorders of the metabolism for electrolyte homeostasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/18Drugs for disorders of the endocrine system of the parathyroid hormones
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/18Bridged systems
SG11201507345RA 2013-03-13 2014-03-13 Dihydropyridazine-3,5-dione derivative SG11201507345RA (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2013051082 2013-03-13
JP2013132889 2013-06-25
PCT/JP2014/056778 WO2014142273A1 (en) 2013-03-13 2014-03-13 Dihydropyridazine-3,5-dione derivative

Publications (1)

Publication Number Publication Date
SG11201507345RA true SG11201507345RA (en) 2015-10-29

Family

ID=51536921

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201507345RA SG11201507345RA (en) 2013-03-13 2014-03-13 Dihydropyridazine-3,5-dione derivative

Country Status (30)

Country Link
EP (2) EP2975030B1 (en)
JP (2) JP5814488B2 (en)
KR (2) KR101664460B1 (en)
CN (1) CN105073715B (en)
AU (1) AU2014230552B2 (en)
BR (1) BR112015022092B1 (en)
CA (1) CA2901868C (en)
CL (1) CL2015002543A1 (en)
CR (1) CR20150505A (en)
DK (1) DK2975030T3 (en)
ES (1) ES2811126T3 (en)
HK (1) HK1212700A1 (en)
HR (1) HRP20201211T1 (en)
HU (1) HUE050577T2 (en)
IL (1) IL240825B (en)
LT (1) LT2975030T (en)
MX (1) MX2015012537A (en)
MY (1) MY174269A (en)
NZ (1) NZ711182A (en)
PE (1) PE20151535A1 (en)
PH (1) PH12015501940B1 (en)
PL (1) PL2975030T3 (en)
PT (1) PT2975030T (en)
RS (1) RS60911B1 (en)
RU (1) RU2662832C2 (en)
SG (1) SG11201507345RA (en)
SI (1) SI2975030T1 (en)
TW (2) TWI683811B (en)
UA (1) UA118755C2 (en)
WO (1) WO2014142273A1 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI2975030T1 (en) * 2013-03-13 2020-10-30 Chugai Seiyaku Kabushiki Kaisha Dihydropyridazine-3,5-dione derivative
ES2881611T3 (en) * 2014-09-12 2021-11-30 Chugai Pharmaceutical Co Ltd Pharmaceutical product containing sodium-dependent phosphate transporter inhibitor
WO2018019721A1 (en) 2016-07-26 2018-02-01 Basf Se Herbicidal pyridine compounds
WO2018019755A1 (en) 2016-07-26 2018-02-01 Basf Se Herbicidal pyridine compounds
CN110885290A (en) * 2019-12-16 2020-03-17 阿里生物新材料(常州)有限公司 Synthetic method of 3-fluoro-2-methyl-4-trifluoromethylaniline hydrochloride
MX2022016133A (en) 2020-06-26 2023-02-09 Nihon Nohyaku Co Ltd Aryltetrahydropyridazine derivative or salt thereof, insecticide comprising said compound, and method for using said insecticide.
WO2022221182A1 (en) * 2021-04-12 2022-10-20 Jnana Therapeutics Inc. Small molecule inhibitors of mammalian slc34a1 function
TW202317118A (en) 2021-06-08 2023-05-01 日商中外製藥股份有限公司 Preparation containing dihydropyridazine-3,5-dione derivative
AR126060A1 (en) 2021-06-08 2023-09-06 Chugai Pharmaceutical Co Ltd METHOD FOR PRODUCING DIHYDROPYRIDAZIN-3,5-DIONE DERIVATIVE
WO2023219127A1 (en) * 2022-05-11 2023-11-16 中外製薬株式会社 Pharmaceutical composition for treating or preventing cystic disease

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100348587C (en) * 2002-02-19 2007-11-14 小野药品工业株式会社 Fused pyridazine derivative compounds and drugs containing the compounds as the active ingredient
CN1662529A (en) * 2002-06-19 2005-08-31 默克专利有限公司 Thiazole derivatives as phosphodiesterase IV inhibitors
KR20080019236A (en) * 2005-05-18 2008-03-03 어레이 바이오파마 인크. Heterocyclic inhibitors of mek and methods of use thereof
GB0610680D0 (en) * 2006-05-31 2006-07-12 Istituto Di Ricerche D Biolog Therapeutic compounds
AR063464A1 (en) * 2006-11-03 2009-01-28 Basf Ag PROCEDURE TO PREPARE DIFLUOROMETILPIRAZOLIL CARBOXYLATES
TW201006821A (en) * 2008-07-16 2010-02-16 Bristol Myers Squibb Co Pyridone and pyridazone analogues as GPR119 modulators
CN102264740B (en) * 2008-08-20 2014-10-15 菲布罗根有限公司 Pyrrolo [ 1, 2 -b] pyridazine derivatives and their use as hif modulators
WO2011048611A1 (en) * 2009-10-07 2011-04-28 Torrent Pharmaceuticals Limited Novel fused pyridazine derivatives
US20130029973A1 (en) 2010-04-28 2013-01-31 Astellas Pharma Inc. Tetrahydrobenzothiophene compound
EP2591354B1 (en) 2010-07-07 2016-09-07 Ardelyx, Inc. Compounds and methods for inhibiting phosphate transport
WO2012006474A2 (en) * 2010-07-07 2012-01-12 Ardelyx, Inc. Compounds and methods for inhibiting phosphate transport
MX342521B (en) 2011-10-27 2016-10-03 Astellas Pharma Inc Aminoalkyl-substituted n-thienyl benzamide derivative.
SI2975030T1 (en) * 2013-03-13 2020-10-30 Chugai Seiyaku Kabushiki Kaisha Dihydropyridazine-3,5-dione derivative

Also Published As

Publication number Publication date
HUE050577T2 (en) 2020-12-28
PH12015501940A1 (en) 2016-01-11
CA2901868A1 (en) 2014-09-18
AU2014230552A1 (en) 2015-08-13
IL240825B (en) 2020-07-30
TWI683811B (en) 2020-02-01
UA118755C2 (en) 2019-03-11
LT2975030T (en) 2020-09-25
JP6420738B2 (en) 2018-11-07
PH12015501940B1 (en) 2016-01-11
EP2975030A4 (en) 2016-08-03
TWI596095B (en) 2017-08-21
KR101664460B1 (en) 2016-10-10
CN105073715A (en) 2015-11-18
CL2015002543A1 (en) 2016-02-26
AU2014230552B2 (en) 2017-11-16
TW201446756A (en) 2014-12-16
KR20160119282A (en) 2016-10-12
PL2975030T3 (en) 2021-01-11
IL240825A0 (en) 2015-10-29
RU2015143507A (en) 2017-04-19
RU2662832C2 (en) 2018-07-31
JP5814488B2 (en) 2015-11-17
HK1212700A1 (en) 2016-06-17
EP2975030A1 (en) 2016-01-20
JP2016040262A (en) 2016-03-24
MY174269A (en) 2020-04-01
PE20151535A1 (en) 2015-10-28
ES2811126T3 (en) 2021-03-10
KR20150127721A (en) 2015-11-17
WO2014142273A1 (en) 2014-09-18
KR102072268B1 (en) 2020-01-31
BR112015022092A8 (en) 2018-01-23
DK2975030T3 (en) 2020-08-31
EP3757093A1 (en) 2020-12-30
BR112015022092B1 (en) 2023-04-11
PT2975030T (en) 2020-09-28
CN105073715B (en) 2017-12-01
JPWO2014142273A1 (en) 2017-02-16
TW201741304A (en) 2017-12-01
CA2901868C (en) 2022-05-03
EP2975030B1 (en) 2020-07-15
MX2015012537A (en) 2016-02-10
CR20150505A (en) 2015-10-26
RS60911B1 (en) 2020-11-30
NZ711182A (en) 2020-05-29
BR112015022092A2 (en) 2017-07-18
HRP20201211T1 (en) 2020-11-13
SI2975030T1 (en) 2020-10-30

Similar Documents

Publication Publication Date Title
HK1215795A1 (en) Amatoxin derivatives
SG11201506100XA (en) Pyridazinone-amides derivatives
IL240825B (en) Dihydropyridazine - 3, 5 - dione derivative
ZA201601333B (en) Oxoquinazolinyl-butanamide derivatives
SG11201605189YA (en) Imidazopyrazinone derivatives
IL241293A0 (en) Novel triazole derivatives
GB201411896D0 (en) .
IL241859B (en) Novel triazole derivatives
HK1213566A1 (en) Novel tetrazolone derivatives
HK1223621A1 (en) Imidazole derivatives
EP3009444A4 (en) Alpha-oxoacyl amino-caprolactam derivative
GB201409791D0 (en) .
GB201322661D0 (en) .
GB201312935D0 (en) T,b,s
GB201308346D0 (en) Double ended match
GB201300322D0 (en) Beataboutmusic.com
GB201301396D0 (en) Ar
GB201300649D0 (en) Cyclization