KR102072268B1 - 디하이드로피리다진-3,5-디온 유도체 - Google Patents
디하이드로피리다진-3,5-디온 유도체 Download PDFInfo
- Publication number
- KR102072268B1 KR102072268B1 KR1020167027514A KR20167027514A KR102072268B1 KR 102072268 B1 KR102072268 B1 KR 102072268B1 KR 1020167027514 A KR1020167027514 A KR 1020167027514A KR 20167027514 A KR20167027514 A KR 20167027514A KR 102072268 B1 KR102072268 B1 KR 102072268B1
- Authority
- KR
- South Korea
- Prior art keywords
- substituted
- alkyl
- alkoxy
- phenyl
- methyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 0 CC[C@](C(C(C*)=C=*)=C(*C)C1(CC)C=C*1C)N Chemical compound CC[C@](C(C(C*)=C=*)=C(*C)C1(CC)C=C*1C)N 0.000 description 12
- LHZAENXXJJSGHR-UHFFFAOYSA-N Bc1cc(OCCOC)c(C(F)(F)F)cc1 Chemical compound Bc1cc(OCCOC)c(C(F)(F)F)cc1 LHZAENXXJJSGHR-UHFFFAOYSA-N 0.000 description 1
- HQUZEIBCNYJCFX-NSCUHMNNSA-N C/C=C/NCCS Chemical compound C/C=C/NCCS HQUZEIBCNYJCFX-NSCUHMNNSA-N 0.000 description 1
- ZAPUGMTZFAFQMT-UHFFFAOYSA-N CC1(C(OC)=O)NCCCC1 Chemical compound CC1(C(OC)=O)NCCCC1 ZAPUGMTZFAFQMT-UHFFFAOYSA-N 0.000 description 1
- GDOPTJXRTPNYNR-UHFFFAOYSA-N CC1CCCC1 Chemical compound CC1CCCC1 GDOPTJXRTPNYNR-UHFFFAOYSA-N 0.000 description 1
- CEJWKANZZDRDPE-BOFKRWBFSA-N CC1OC[C@@H](COC/C=C/S)O/C1=C\C Chemical compound CC1OC[C@@H](COC/C=C/S)O/C1=C\C CEJWKANZZDRDPE-BOFKRWBFSA-N 0.000 description 1
- KXEAPTKIGYWRFL-GCZGRYASSA-N CCCCCN[NH+](/C(/C(OC)=O)=C(\[C@]1(C)NCCC1)/O)[O-] Chemical compound CCCCCN[NH+](/C(/C(OC)=O)=C(\[C@]1(C)NCCC1)/O)[O-] KXEAPTKIGYWRFL-GCZGRYASSA-N 0.000 description 1
- LLUHXQZGXOMQQU-OEAKJJBVSA-N CN(CCOC)CCOc(ccc(/C=N/N(C)C1(CCC1)C(OC)=O)c1F)c1F Chemical compound CN(CCOC)CCOc(ccc(/C=N/N(C)C1(CCC1)C(OC)=O)c1F)c1F LLUHXQZGXOMQQU-OEAKJJBVSA-N 0.000 description 1
- CSIPMPYXUPIYEG-BUVRLJJBSA-N CN(CCOC)CCOc(ccc(/C=N/N(C)C1(CCCC1)C(OC)=O)c1F)c1F Chemical compound CN(CCOC)CCOc(ccc(/C=N/N(C)C1(CCCC1)C(OC)=O)c1F)c1F CSIPMPYXUPIYEG-BUVRLJJBSA-N 0.000 description 1
- XDTMAHQUMYJHDR-UHFFFAOYSA-N CN(CCOC)CCOc(cccc1F)c1F Chemical compound CN(CCOC)CCOc(cccc1F)c1F XDTMAHQUMYJHDR-UHFFFAOYSA-N 0.000 description 1
- IHIJKZYDEDKOQN-UHFFFAOYSA-N CN(CCOC)CCOc1ccc(CN(C(CC(Nc2ccc(C(F)(F)F)cc2-c2ncnc(C(F)(F)F)c2)=O)=O)N(C)C2(CCC2)C(OC)=O)c(F)c1F Chemical compound CN(CCOC)CCOc1ccc(CN(C(CC(Nc2ccc(C(F)(F)F)cc2-c2ncnc(C(F)(F)F)c2)=O)=O)N(C)C2(CCC2)C(OC)=O)c(F)c1F IHIJKZYDEDKOQN-UHFFFAOYSA-N 0.000 description 1
- MISXNAQMZZCFST-UHFFFAOYSA-N COCCOc(c(C(F)(F)F)c1)cc(N)c1-c(cccc1OC)c1OC Chemical compound COCCOc(c(C(F)(F)F)c1)cc(N)c1-c(cccc1OC)c1OC MISXNAQMZZCFST-UHFFFAOYSA-N 0.000 description 1
- UVGVAYJKKHTYCH-JGCGQSQUSA-N C[C@@](CCC1)(C(N)=C2C(Nc(ccc(C(F)(F)F)c3)c3-c(cc3NC)cnc3N3CCOCC3)=O)N1N(Cc1cccc(F)c1F)C2=O Chemical compound C[C@@](CCC1)(C(N)=C2C(Nc(ccc(C(F)(F)F)c3)c3-c(cc3NC)cnc3N3CCOCC3)=O)N1N(Cc1cccc(F)c1F)C2=O UVGVAYJKKHTYCH-JGCGQSQUSA-N 0.000 description 1
- FHNCCYWKTKDDPE-FAOTXVLUSA-N C[C@@](CCC1)(C(O)=C2C(Nc3c(C4NC=NC(C(F)(F)F)=C4)cc(C(F)(F)F)cc3)=O)N1N(CC(C1F)=CCCC1F)C2=O Chemical compound C[C@@](CCC1)(C(O)=C2C(Nc3c(C4NC=NC(C(F)(F)F)=C4)cc(C(F)(F)F)cc3)=O)N1N(CC(C1F)=CCCC1F)C2=O FHNCCYWKTKDDPE-FAOTXVLUSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/504—Pyridazines; Hydrogenated pyridazines forming part of bridged ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/04—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having less than three double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/18—Bridged systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Luminescent Compositions (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2013051082 | 2013-03-13 | ||
| JPJP-P-2013-051082 | 2013-03-13 | ||
| JPJP-P-2013-132889 | 2013-06-25 | ||
| JP2013132889 | 2013-06-25 | ||
| PCT/JP2014/056778 WO2014142273A1 (ja) | 2013-03-13 | 2014-03-13 | ジヒドロピリダジン－３，５－ジオン誘導体 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020157029079A Division KR101664460B1 (ko) | 2013-03-13 | 2014-03-13 | 디하이드로피리다진-3,5-디온 유도체 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20160119282A KR20160119282A (ko) | 2016-10-12 |
| KR102072268B1 true KR102072268B1 (ko) | 2020-01-31 |
Family
ID=51536921
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020157029079A Active KR101664460B1 (ko) | 2013-03-13 | 2014-03-13 | 디하이드로피리다진-3,5-디온 유도체 |
| KR1020167027514A Active KR102072268B1 (ko) | 2013-03-13 | 2014-03-13 | 디하이드로피리다진-3,5-디온 유도체 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020157029079A Active KR101664460B1 (ko) | 2013-03-13 | 2014-03-13 | 디하이드로피리다진-3,5-디온 유도체 |
Country Status (29)
| Country | Link |
|---|---|
| EP (2) | EP3757093A1 (enExample) |
| JP (2) | JP5814488B2 (enExample) |
| KR (2) | KR101664460B1 (enExample) |
| CN (1) | CN105073715B (enExample) |
| AU (1) | AU2014230552B2 (enExample) |
| BR (1) | BR112015022092B1 (enExample) |
| CA (1) | CA2901868C (enExample) |
| CL (1) | CL2015002543A1 (enExample) |
| CR (1) | CR20150505A (enExample) |
| DK (1) | DK2975030T3 (enExample) |
| ES (1) | ES2811126T3 (enExample) |
| HR (1) | HRP20201211T1 (enExample) |
| HU (1) | HUE050577T2 (enExample) |
| IL (1) | IL240825B (enExample) |
| LT (1) | LT2975030T (enExample) |
| MX (1) | MX376532B (enExample) |
| MY (1) | MY174269A (enExample) |
| NZ (1) | NZ711182A (enExample) |
| PE (1) | PE20151535A1 (enExample) |
| PH (1) | PH12015501940A1 (enExample) |
| PL (1) | PL2975030T3 (enExample) |
| PT (1) | PT2975030T (enExample) |
| RS (1) | RS60911B1 (enExample) |
| RU (1) | RU2662832C2 (enExample) |
| SG (1) | SG11201507345RA (enExample) |
| SI (1) | SI2975030T1 (enExample) |
| TW (2) | TWI596095B (enExample) |
| UA (1) | UA118755C2 (enExample) |
| WO (1) | WO2014142273A1 (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HRP20201211T1 (hr) * | 2013-03-13 | 2020-11-13 | Chugai Seiyaku Kabushiki Kaisha | Derivat dihidropiridazin-3,5-diona |
| EP3928779B1 (en) * | 2014-09-12 | 2024-03-06 | Chugai Seiyaku Kabushiki Kaisha | Pharmaceutical containing sodium-dependent phosphate transporter inhibitor and phosphorus adsorbent for use in the prevention, treatment or suppression of chronic kidney disease, arteriosclerosis associated with vascular calcification, or ectopic calcification. |
| WO2018019721A1 (en) | 2016-07-26 | 2018-02-01 | Basf Se | Herbicidal pyridine compounds |
| WO2018019755A1 (en) | 2016-07-26 | 2018-02-01 | Basf Se | Herbicidal pyridine compounds |
| CN110885290A (zh) * | 2019-12-16 | 2020-03-17 | 阿里生物新材料（常州）有限公司 | 一种3-氟-2-甲基-4-三氟甲基苯胺盐酸盐的合成方法 |
| CN115734965B (zh) | 2020-06-26 | 2025-05-02 | 日本农药株式会社 | 芳基四氢哒嗪衍生物或其盐类、和含有该化合物的杀虫剂及其使用方法 |
| WO2022221182A1 (en) * | 2021-04-12 | 2022-10-20 | Jnana Therapeutics Inc. | Small molecule inhibitors of mammalian slc34a1 function |
| KR20240018523A (ko) | 2021-06-08 | 2024-02-13 | 추가이 세이야쿠 가부시키가이샤 | 다이하이드로피리다진-3,5-다이온 유도체를 함유하는 제제 |
| AR126060A1 (es) * | 2021-06-08 | 2023-09-06 | Chugai Pharmaceutical Co Ltd | Método para producir derivado de dihidropiridazin-3,5-diona |
| WO2023127805A1 (ja) | 2021-12-28 | 2023-07-06 | 日本農薬株式会社 | アリールテトラヒドロピリダジン誘導体又はその塩類及び該化合物を含有する殺虫剤並びにその使用方法 |
| WO2023219127A1 (ja) | 2022-05-11 | 2023-11-16 | 中外製薬株式会社 | 嚢胞性疾患を治療または予防するための医薬組成物 |
| CN116217862A (zh) * | 2023-03-21 | 2023-06-06 | 中国农业科学院农业环境与可持续发展研究所 | 一种可降解生物膜助剂的制备方法 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010009183A1 (en) | 2008-07-16 | 2010-01-21 | Bristol-Myers Squibb Company | Pyridone and pyridazone analogues as gpr119 modulators |
| WO2010022240A1 (en) | 2008-08-20 | 2010-02-25 | Fibrogen, Inc. | Pyrrolo [ 1, 2 -b] pyridazine derivatives and their use as hif modulators |
| WO2011048611A1 (en) | 2009-10-07 | 2011-04-28 | Torrent Pharmaceuticals Limited | Novel fused pyridazine derivatives |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2003211381B9 (en) * | 2002-02-19 | 2009-07-30 | Ono Pharmaceutical Co., Ltd. | Fused pyridazine derivative compounds and drugs containing the compounds as the active ingredient |
| CN1662529A (zh) * | 2002-06-19 | 2005-08-31 | 默克专利有限公司 | 作为磷酸二酯酶iv抑制剂的噻唑衍生物 |
| NZ563707A (en) * | 2005-05-18 | 2011-01-28 | Array Biopharma Inc | Heterocyclic inhibitors of MEK and methods of use thereof |
| GB0610680D0 (en) * | 2006-05-31 | 2006-07-12 | Istituto Di Ricerche D Biolog | Therapeutic compounds |
| EA017900B1 (ru) * | 2006-11-03 | 2013-04-30 | Басф Се | Способ получения дифторметилпиразолилкарбоксилатов |
| US20130029973A1 (en) | 2010-04-28 | 2013-01-31 | Astellas Pharma Inc. | Tetrahydrobenzothiophene compound |
| WO2012006475A1 (en) | 2010-07-07 | 2012-01-12 | Ardelyx, Inc. | Compounds and methods for inhibiting phosphate transport |
| EP2590965B1 (en) * | 2010-07-07 | 2016-04-20 | Ardelyx, Inc. | Compounds and methods for inhibiting phosphate transport |
| PL2772490T3 (pl) | 2011-10-27 | 2016-11-30 | Aminoalkilo-podstawiona pochodna n-tienylobenzamidu | |
| HRP20201211T1 (hr) * | 2013-03-13 | 2020-11-13 | Chugai Seiyaku Kabushiki Kaisha | Derivat dihidropiridazin-3,5-diona |
-
2014
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