US6849708B1
(en)
|
1986-05-05 |
2005-02-01 |
The General Hospital Corporation |
Insulinotropic hormone and uses thereof
|
US7138486B2
(en)
|
1986-05-05 |
2006-11-21 |
The General Hospital Corporation |
Insulinotropic hormone derivatives and uses thereof
|
US5614492A
(en)
*
|
1986-05-05 |
1997-03-25 |
The General Hospital Corporation |
Insulinotropic hormone GLP-1 (7-36) and uses thereof
|
US6284727B1
(en)
|
1993-04-07 |
2001-09-04 |
Scios, Inc. |
Prolonged delivery of peptides
|
US5705483A
(en)
|
1993-12-09 |
1998-01-06 |
Eli Lilly And Company |
Glucagon-like insulinotropic peptides, compositions and methods
|
US20020006899A1
(en)
*
|
1998-10-06 |
2002-01-17 |
Pospisilik Andrew J. |
Use of dipeptidyl peptidase IV effectors for lowering blood pressure in mammals
|
ES2359031T3
(es)
*
|
1996-08-08 |
2011-05-17 |
Amylin Pharmaceuticals, Inc. |
Composición farmacéutica que comprende un péptido de exendina-4.
|
JP4798814B2
(ja)
*
|
1997-01-07 |
2011-10-19 |
アミリン・ファーマシューティカルズ,インコーポレイテッド |
食物摂取低減用のエキセンジンおよびそのアゴニストの使用
|
JP2002510193A
(ja)
*
|
1997-03-31 |
2002-04-02 |
イーライ・リリー・アンド・カンパニー |
グルカゴン様ペプチド−1類似体
|
WO1998043658A1
(en)
*
|
1997-03-31 |
1998-10-08 |
Eli Lilly And Company |
Glucagon-like peptide-1 analogs
|
US7157555B1
(en)
*
|
1997-08-08 |
2007-01-02 |
Amylin Pharmaceuticals, Inc. |
Exendin agonist compounds
|
ATE381939T1
(de)
|
1997-11-14 |
2008-01-15 |
Amylin Pharmaceuticals Inc |
Neuartige exendin agonisten
|
US7220721B1
(en)
*
|
1997-11-14 |
2007-05-22 |
Amylin Pharmaceuticals, Inc. |
Exendin agonist peptides
|
EP1049486A4
(en)
*
|
1997-12-05 |
2006-01-04 |
Lilly Co Eli |
GLP-1 FORMULATIONS
|
US6380357B2
(en)
*
|
1997-12-16 |
2002-04-30 |
Eli Lilly And Company |
Glucagon-like peptide-1 crystals
|
FR2777283B1
(fr)
*
|
1998-04-10 |
2000-11-24 |
Adir |
Nouveaux composes peptidiques analogues du glucagon-peptide- 1 (7-37), leur procede de preparation et les compositions pharmaceutiques qui les contiennent
|
DE19823831A1
(de)
*
|
1998-05-28 |
1999-12-02 |
Probiodrug Ges Fuer Arzneim |
Neue pharmazeutische Verwendung von Isoleucyl Thiazolidid und seinen Salzen
|
DE19828113A1
(de)
*
|
1998-06-24 |
2000-01-05 |
Probiodrug Ges Fuer Arzneim |
Prodrugs von Inhibitoren der Dipeptidyl Peptidase IV
|
EP1306091A3
(en)
*
|
1998-07-31 |
2003-05-21 |
Novo Nordisk A/S |
Stimulation of beta cell proliferation
|
EP1666054A1
(en)
|
1998-08-28 |
2006-06-07 |
Eli Lilly & Company |
Method for administering insulinotropic peptides
|
US6720407B1
(en)
*
|
1998-08-28 |
2004-04-13 |
Eli Lilly And Company |
Method for administering insulinotropic peptides
|
CA2343268A1
(en)
|
1998-09-17 |
2000-03-23 |
Eli Lilly And Company |
Protein formulations
|
US20030176357A1
(en)
*
|
1998-10-06 |
2003-09-18 |
Pospisilik Andrew J. |
Dipeptidyl peptidase IV inhibitors and their uses for lowering blood pressure levels
|
US6284725B1
(en)
*
|
1998-10-08 |
2001-09-04 |
Bionebraska, Inc. |
Metabolic intervention with GLP-1 to improve the function of ischemic and reperfused tissue
|
US7259136B2
(en)
*
|
1999-04-30 |
2007-08-21 |
Amylin Pharmaceuticals, Inc. |
Compositions and methods for treating peripheral vascular disease
|
PT1137666E
(pt)
*
|
1998-12-07 |
2008-06-02 |
Sod Conseils Rech Applic |
Análogos de glp-1
|
CN1495198A
(zh)
*
|
1998-12-07 |
2004-05-12 |
�о���Ӧ�ÿ�ѧЭ��ɷ�����˾ |
胰高血糖素样肽-1的类似物
|
CA2358107C
(en)
*
|
1998-12-22 |
2011-08-23 |
Eli Lilly And Company |
Shelf-stable formulation of glucagon-like peptide-1
|
EP1600162A1
(en)
*
|
1998-12-22 |
2005-11-30 |
Eli Lilly & Company |
Shelf-stable formulation of glucagon-like peptide-1
|
US20050272652A1
(en)
|
1999-03-29 |
2005-12-08 |
Gault Victor A |
Peptide analogues of GIP for treatment of diabetes, insulin resistance and obesity
|
US6605648B1
(en)
*
|
1999-04-06 |
2003-08-12 |
Phillips Plastics Corporation |
Sinterable structures and method
|
US6514500B1
(en)
|
1999-10-15 |
2003-02-04 |
Conjuchem, Inc. |
Long lasting synthetic glucagon like peptide {GLP-!}
|
ES2209885T3
(es)
|
1999-05-17 |
2004-07-01 |
Conjuchem, Inc. |
Peptidos insulinotropicos de larga duracion.
|
US20090175821A1
(en)
*
|
1999-05-17 |
2009-07-09 |
Bridon Dominique P |
Modified therapeutic peptides with extended half-lives in vivo
|
WO2000078333A2
(en)
|
1999-06-21 |
2000-12-28 |
Eli Lilly And Company |
Synergetic use of thiazolidinediones with glucagon-like peptide-1 and agonists thereof to treat non-insulin dependant diabetes
|
US6864234B1
(en)
*
|
1999-06-25 |
2005-03-08 |
Societe De Conseils De Recherches Et D'applications Scientifiques, S.A.S. |
Somatostatin agonists
|
WO2001000654A2
(en)
|
1999-06-29 |
2001-01-04 |
Pharmaceutical Discovery Corporation |
Purification and stabilization of peptide and proteins in pharmaceutical agents
|
US9006175B2
(en)
|
1999-06-29 |
2015-04-14 |
Mannkind Corporation |
Potentiation of glucose elimination
|
DE19940130A1
(de)
*
|
1999-08-24 |
2001-03-01 |
Probiodrug Ges Fuer Arzneim |
Neue Effektoren der Dipeptidyl Peptidase IV zur topischen Anwendung
|
BRPI0107715B8
(pt)
|
2000-01-21 |
2021-05-25 |
Novartis Ag |
produto farmacêutico compreendendo um inibidor de dipeptidilpeptidase-iv e metformina, bem como usos do dito produto farmacêutico e do inibidor de dipeptidilpeptidase-iv
|
US6448045B1
(en)
*
|
2000-03-10 |
2002-09-10 |
The Regents Of The University Of California |
Inducing insulin gene expression in pancreas cells expressing recombinant PDX-1
|
EP2266665B1
(en)
*
|
2000-03-31 |
2016-05-11 |
Royalty Pharma Collection Trust |
Method for the improvement of islet signaling in diabetes mellitus and for its prevention
|
DK1695983T3
(da)
*
|
2000-06-16 |
2009-05-18 |
Lilly Co Eli |
Glucagon-lignende peptid-1 analoger
|
KR100407792B1
(ko)
*
|
2000-08-02 |
2003-12-01 |
한국생명공학연구원 |
인간 글루카곤 유사펩타이드를 융합파트너로 이용한재조합 단백질의 제조방법
|
AR033390A1
(es)
|
2000-08-22 |
2003-12-17 |
Novartis Ag |
Una composicion farmaceutica que comprende un antagonista del receptor at1 y un potenciador de la secrecion de insulina, el uso de dicha composicion para la fabricacion de un medicamento y un kit de partes
|
EP1322158B1
(en)
*
|
2000-10-02 |
2012-08-08 |
USV Ltd. |
Sustained release pharmaceutical compositions containing metformin and method of their production
|
EP1328270A2
(en)
*
|
2000-10-27 |
2003-07-23 |
Probiodrug AG |
Method for the treatment of neurological and neuropsychological disorders
|
CA2430934C
(en)
|
2000-12-01 |
2011-06-21 |
Takeda Chemical Industries, Ltd. |
A method of producing sustained-release preparations of a bioactive substance using high-pressure gas
|
WO2002047716A2
(en)
*
|
2000-12-13 |
2002-06-20 |
Eli Lilly And Company |
Chronic treatment regimen using glucagon-like insulinotropic peptides
|
AU2002228608A1
(en)
*
|
2000-12-13 |
2002-06-24 |
Eli Lilly And Company |
Amidated glucagon-like peptide-1
|
EP1385549A2
(en)
*
|
2001-03-12 |
2004-02-04 |
Novartis AG |
Combination of nateglinide or repaglinide with at least one further antidiabetic compound
|
US6573237B2
(en)
|
2001-03-16 |
2003-06-03 |
Eli Lilly And Company |
Protein formulations
|
US7368421B2
(en)
*
|
2001-06-27 |
2008-05-06 |
Probiodrug Ag |
Use of dipeptidyl peptidase IV inhibitors in the treatment of multiple sclerosis
|
US20030130199A1
(en)
*
|
2001-06-27 |
2003-07-10 |
Von Hoersten Stephan |
Dipeptidyl peptidase IV inhibitors and their uses as anti-cancer agents
|
US20030119734A1
(en)
*
|
2001-06-28 |
2003-06-26 |
Flink James M. |
Stable formulation of modified GLP-1
|
UA74912C2
(en)
*
|
2001-07-06 |
2006-02-15 |
Merck & Co Inc |
Beta-aminotetrahydroimidazo-(1,2-a)-pyrazines and tetratriazolo-(4,3-a)-pyrazines as inhibitors of dipeptylpeptidase for the treatment or prevention of diabetes
|
US6642003B2
(en)
|
2001-08-02 |
2003-11-04 |
Cedars-Sinai Medical Center |
Human glucose-dependent insulin-secreting cell line
|
WO2003015768A2
(en)
*
|
2001-08-16 |
2003-02-27 |
Probiodrug Ag |
Use of inhibitors of proline endopeptidase to modulate inositol (1,4,5) triphosphate concentration dependent on intracellular signal cascades
|
WO2003020201A2
(en)
*
|
2001-08-28 |
2003-03-13 |
Eli Lilly And Company |
Pre-mixes of glp-1 and basal insulin
|
US6844316B2
(en)
*
|
2001-09-06 |
2005-01-18 |
Probiodrug Ag |
Inhibitors of dipeptidyl peptidase I
|
US6911324B2
(en)
|
2001-10-18 |
2005-06-28 |
The Regents Of The University Of California |
Induction of beta cell differentiation in human cells
|
US7179788B2
(en)
*
|
2001-10-19 |
2007-02-20 |
Eli Lilly And Company |
Biphasic mixtures of GLP-1 and insulin
|
US7332819B2
(en)
*
|
2002-01-09 |
2008-02-19 |
Micron Technology, Inc. |
Stacked die in die BGA package
|
AU2002364587A1
(en)
*
|
2001-12-21 |
2003-07-30 |
Human Genome Sciences, Inc. |
Albumin fusion proteins
|
EP2261250B1
(en)
|
2001-12-21 |
2015-07-01 |
Human Genome Sciences, Inc. |
GCSF-Albumin fusion proteins
|
US7105489B2
(en)
*
|
2002-01-22 |
2006-09-12 |
Amylin Pharmaceuticals, Inc. |
Methods and compositions for treating polycystic ovary syndrome
|
NZ534125A
(en)
*
|
2002-02-20 |
2006-11-30 |
Emisphere Tech Inc |
A formulation comprising a GLP-1 compound and a delivery agent
|
US7141240B2
(en)
*
|
2002-03-12 |
2006-11-28 |
Cedars-Sinai Medical Center |
Glucose-dependent insulin-secreting cells transfected with a nucleotide sequence encoding GLP-1
|
EP1894591B1
(en)
|
2002-03-20 |
2013-06-26 |
MannKind Corporation |
Cartridge for an inhalation apparatus
|
US20030232761A1
(en)
*
|
2002-03-28 |
2003-12-18 |
Hinke Simon A. |
Novel analogues of glucose-dependent insulinotropic polypeptide
|
US20030191056A1
(en)
|
2002-04-04 |
2003-10-09 |
Kenneth Walker |
Use of transthyretin peptide/protein fusions to increase the serum half-life of pharmacologically active peptides/proteins
|
WO2004005342A1
(en)
|
2002-07-04 |
2004-01-15 |
Zealand Pharma A/S |
Glp-1 and methods for treating diabetes
|
US20080260838A1
(en)
*
|
2003-08-01 |
2008-10-23 |
Mannkind Corporation |
Glucagon-like peptide 1 (glp-1) pharmaceutical formulations
|
EP1543023B1
(en)
*
|
2002-09-18 |
2010-03-17 |
Prosidion Limited |
Secondary binding site of dipeptidyl peptidase iv (dp iv)
|
US20040058876A1
(en)
*
|
2002-09-18 |
2004-03-25 |
Torsten Hoffmann |
Secondary binding site of dipeptidyl peptidase IV (DP IV)
|
US7067488B2
(en)
|
2002-09-25 |
2006-06-27 |
Theratechnologies Inc. |
Modified GLP-1 peptides with increased biological potency
|
PL377591A1
(pl)
|
2002-10-02 |
2006-02-06 |
Zealand Pharma A/S |
Stabilizowane związki eksendyny-4
|
US20040209801A1
(en)
*
|
2002-10-22 |
2004-10-21 |
Brand Stephen J. |
Treatment of diabetes
|
US20040209803A1
(en)
*
|
2002-12-19 |
2004-10-21 |
Alain Baron |
Compositions for the treatment and prevention of nephropathy
|
US7790681B2
(en)
*
|
2002-12-17 |
2010-09-07 |
Amylin Pharmaceuticals, Inc. |
Treatment of cardiac arrhythmias with GLP-1 receptor ligands
|
WO2004060387A1
(en)
*
|
2002-12-27 |
2004-07-22 |
Diobex, Inc. |
Compositions and methods for the prevention and control of insulin-induced hypoglycemia
|
US7655618B2
(en)
*
|
2002-12-27 |
2010-02-02 |
Diobex, Inc. |
Compositions and methods for the prevention and control of insulin-induced hypoglycemia
|
CN1750842A
(zh)
*
|
2003-02-19 |
2006-03-22 |
研究及应用科学协会股份有限公司 |
Glp-1的类似物
|
CA2518336A1
(en)
*
|
2003-03-19 |
2004-11-04 |
Eli Lilly And Company |
Polyethelene glycol link glp-1 compounds
|
CN1774281B
(zh)
*
|
2003-04-15 |
2010-10-13 |
奥珀百思控股公司 |
包含蛋白质和/或多肽以及胶体颗粒的药物组合物
|
EP1620091B1
(en)
*
|
2003-05-05 |
2010-03-31 |
Probiodrug AG |
Inhibitors of glutaminyl cyclase
|
PT1620082E
(pt)
*
|
2003-05-05 |
2010-06-11 |
Probiodrug Ag |
Utilização médica de inibidores de ciclases de glutaminilo e glutamato para o tratamento da doença de alzheimer e síndrome de down
|
EP1631308B1
(en)
*
|
2003-05-30 |
2013-07-31 |
Amylin Pharmaceuticals, LLC |
Novel methods and compositions for enhanced transmucosal delivery of peptides and proteins
|
WO2004105790A1
(en)
*
|
2003-06-03 |
2004-12-09 |
Novo Nordisk A/S |
Stabilized pharmaceutical peptide compositions
|
CN102940879B
(zh)
*
|
2003-06-03 |
2017-06-06 |
诺沃挪第克公司 |
稳定化的药物肽组合物
|
CN1812808B
(zh)
*
|
2003-06-03 |
2012-07-04 |
诺沃挪第克公司 |
稳定化的药物肽组合物
|
JP5707014B2
(ja)
*
|
2003-10-15 |
2015-04-22 |
プロビオドルグ エージー |
グルタミニル、及びグルタミン酸シクラーゼのエフェクターの使用
|
KR101243648B1
(ko)
*
|
2003-11-20 |
2013-03-14 |
노보 노르디스크 에이/에스 |
제조 및 주사 장치용에 최적인 프로필렌 글리콜 함유펩티드 제제
|
CA2550695A1
(en)
*
|
2003-12-16 |
2005-06-30 |
Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R |
Glp-1 pharmaceutical compositions
|
ES2393335T3
(es)
|
2003-12-16 |
2012-12-20 |
Ipsen Pharma |
Análogos de GLP-1
|
US20060286129A1
(en)
*
|
2003-12-19 |
2006-12-21 |
Emisphere Technologies, Inc. |
Oral GLP-1 formulations
|
RU2006131046A
(ru)
*
|
2004-01-30 |
2008-03-10 |
Уэрейта Фармасьютикалз, Инк. (Ca) |
Совместное применение агониста glp-1 и соединений гастрина
|
KR101099206B1
(ko)
|
2004-02-05 |
2011-12-27 |
프로비오드룩 아게 |
신규한 글루타미닐 시클라제 저해제
|
EP1729795B1
(en)
*
|
2004-02-09 |
2016-02-03 |
Human Genome Sciences, Inc. |
Albumin fusion proteins
|
EP2100904B1
(en)
*
|
2004-04-23 |
2010-07-07 |
ConjuChem Biotechnologies Inc. |
Solid phase for use in a method for the purification of albumin conjugates
|
US20090069226A1
(en)
*
|
2004-05-28 |
2009-03-12 |
Amylin Pharmaceuticals, Inc. |
Transmucosal delivery of peptides and proteins
|
DK1786784T3
(da)
|
2004-08-20 |
2011-02-14 |
Mannkind Corp |
Katalyse af diketopiperazinsyntese
|
CN104436170B
(zh)
|
2004-08-23 |
2018-02-23 |
曼金德公司 |
用于药物输送的二酮哌嗪盐
|
PL1789434T3
(pl)
*
|
2004-08-31 |
2014-07-31 |
Novo Nordisk As |
Zastosowanie tris(hydroksymetylo)aminometanu do stabilizacji peptydów, polipeptydów i białek
|
DE102004043153B4
(de)
*
|
2004-09-03 |
2013-11-21 |
Philipps-Universität Marburg |
Erfindung betreffend GLP-1 und Exendin
|
JP5175103B2
(ja)
*
|
2004-11-12 |
2013-04-03 |
ノヴォ ノルディスク アー/エス |
安定なペプチド製剤
|
WO2006069779A1
(en)
*
|
2004-12-30 |
2006-07-06 |
F. Hoffmann-La Roche Ag |
Preparing of peptides with excellent solubility
|
WO2006069697A1
(en)
*
|
2004-12-30 |
2006-07-06 |
F. Hoffmann-La Roche Ag |
Colorimetrically assessing peptide characteristics
|
AU2006213607A1
(en)
|
2005-02-11 |
2006-08-17 |
Amylin Pharmaceuticals, Llc |
GIP analog and hybrid polypeptides with selectable properties
|
US8263545B2
(en)
|
2005-02-11 |
2012-09-11 |
Amylin Pharmaceuticals, Inc. |
GIP analog and hybrid polypeptides with selectable properties
|
WO2006097535A2
(en)
*
|
2005-03-18 |
2006-09-21 |
Novo Nordisk A/S |
Peptide agonists of the glucagon family with secretin like activity
|
JP2009501002A
(ja)
|
2005-06-07 |
2009-01-15 |
ザ ロックフェラー ユニバーシティ |
膵臓β細胞増殖の刺激方法
|
MX2008001468A
(es)
*
|
2005-06-30 |
2008-04-07 |
Sod Conseils Rech Applic |
Composiciones farmaceuticas del peptido similar al glucagon-1.
|
US20070004616A1
(en)
*
|
2005-06-30 |
2007-01-04 |
Roland Cherif-Cheikh |
GLP-1 pharmaceutical compositions
|
GT200600381A
(es)
|
2005-08-25 |
2007-03-28 |
|
Compuestos organicos
|
HUE028623T2
(en)
|
2005-09-14 |
2016-12-28 |
Mannkind Corp |
Active substance formulation method based on increasing the affinity of the active ingredient for binding to the surface of crystalline microparticles
|
ES2397289T3
(es)
|
2005-09-22 |
2013-03-06 |
Biocompatibles Uk Ltd. |
Polipéptidos de fusión de GLP-1 (péptido 1 de tipo glucagón) con resistencia a peptidasa incrementada
|
WO2007051987A1
(en)
*
|
2005-11-01 |
2007-05-10 |
Activotec Spp Limited |
Insulinotropic compounds and uses thereof
|
GB0522295D0
(en)
*
|
2005-11-01 |
2005-12-07 |
Activotec Spp Ltd |
Peptides and uses thereof
|
US8039432B2
(en)
*
|
2005-11-09 |
2011-10-18 |
Conjuchem, Llc |
Method of treatment of diabetes and/or obesity with reduced nausea side effect
|
CN100374462C
(zh)
*
|
2005-11-21 |
2008-03-12 |
大连帝恩生物工程有限公司 |
截短胰高血糖素样肽1(sGLP-1)、制法及其应用
|
US20130172274A1
(en)
|
2005-12-20 |
2013-07-04 |
Duke University |
Methods and compositions for delivering active agents with enhanced pharmacological properties
|
US8841255B2
(en)
|
2005-12-20 |
2014-09-23 |
Duke University |
Therapeutic agents comprising fusions of vasoactive intestinal peptide and elastic peptides
|
EP1971355B1
(en)
|
2005-12-20 |
2020-03-11 |
Duke University |
Methods and compositions for delivering active agents with enhanced pharmacological properties
|
EP1976876A4
(en)
*
|
2005-12-22 |
2010-01-13 |
Conjuchem Biotechnologies Inc |
PROCESS FOR PRODUCING PREFORMED ALBUMIN CONJUGATES AND THERAPEUTIC AGENT
|
IN2015DN00888A
(cs)
|
2006-02-22 |
2015-07-10 |
Mannkind Corp |
|
MX2008013304A
(es)
*
|
2006-04-20 |
2008-10-27 |
Amgen Inc |
Compuestos de peptido 1 tipo glucagon.
|
AU2007263043B2
(en)
*
|
2006-06-23 |
2012-11-29 |
F. Hoffmann-La Roche Ag |
Insulinotropic peptide synthesis
|
US8071103B2
(en)
|
2006-07-18 |
2011-12-06 |
Centocor, Inc. |
Pharmaceutical composition comprising a human GLP-1 mimetibody
|
US8497240B2
(en)
|
2006-08-17 |
2013-07-30 |
Amylin Pharmaceuticals, Llc |
DPP-IV resistant GIP hybrid polypeptides with selectable properties
|
TW200843794A
(en)
*
|
2006-12-21 |
2008-11-16 |
Centocor Inc |
Use of long-acting GLP-1 receptor agonists to improve insulin sensitivity and lipid profiles
|
JP2008169195A
(ja)
|
2007-01-05 |
2008-07-24 |
Hanmi Pharmaceutical Co Ltd |
キャリア物質を用いたインスリン分泌ペプチド薬物結合体
|
GB2448895A
(en)
*
|
2007-05-01 |
2008-11-05 |
Activotec Spp Ltd |
GLP-1 like compounds and uses thereof
|
US20100292133A1
(en)
|
2007-09-05 |
2010-11-18 |
Novo Nordisk A/S |
Truncated glp-1 derivaties and their therapeutical use
|
CN101868476B
(zh)
*
|
2007-09-05 |
2015-02-25 |
诺沃-诺迪斯克有限公司 |
胰高血糖素样肽-1衍生物及其制药用途
|
US8785396B2
(en)
|
2007-10-24 |
2014-07-22 |
Mannkind Corporation |
Method and composition for treating migraines
|
WO2009055740A2
(en)
*
|
2007-10-24 |
2009-04-30 |
Mannkind Corporation |
Method of preventing adverse effects by glp-1
|
BRPI0818874A2
(pt)
|
2007-10-24 |
2015-05-05 |
Mannkind Corp |
Liberação de agentes ativos
|
DK2205624T3
(da)
*
|
2007-10-27 |
2017-01-02 |
Corden Pharma Colorado Inc |
Insulinotropisk peptidsyntese under anvendelse af faststof- og opløsningsfasekombinationsteknikker
|
CN101918027A
(zh)
*
|
2007-11-02 |
2010-12-15 |
森托科尔奥索生物科技公司 |
半合成GLP-1肽-Fc融合构造、方法及其用途
|
CA2708762A1
(en)
*
|
2007-12-11 |
2009-06-18 |
Conjuchem Biotechnologies Inc. |
Formulation of insulinotropic peptide conjugates
|
US20100317057A1
(en)
|
2007-12-28 |
2010-12-16 |
Novo Nordisk A/S |
Semi-recombinant preparation of glp-1 analogues
|
ES2570400T3
(es)
|
2008-06-13 |
2016-05-18 |
Mannkind Corp |
Un inhalador de polvo seco y un sistema para el suministro de fármacos
|
US8485180B2
(en)
|
2008-06-13 |
2013-07-16 |
Mannkind Corporation |
Dry powder drug delivery system
|
JP5479465B2
(ja)
|
2008-06-20 |
2014-04-23 |
マンカインド コーポレイション |
吸入努力をリアルタイムにプロファイルする対話式機器および方法
|
WO2009158704A2
(en)
*
|
2008-06-27 |
2009-12-30 |
Duke University |
Therapeutic agents comprising elastin-like peptides
|
TWI532497B
(zh)
|
2008-08-11 |
2016-05-11 |
曼凱公司 |
超快起作用胰島素之用途
|
HUE037449T2
(hu)
|
2008-10-17 |
2018-08-28 |
Sanofi Aventis Deutschland |
Egy inzulin és egy GLP-1 agonista kombinációja
|
WO2010056717A1
(en)
*
|
2008-11-17 |
2010-05-20 |
Merck Sharp & Dohme Corp. |
Substituted bicyclic amines for the treatment of diabetes
|
US8314106B2
(en)
|
2008-12-29 |
2012-11-20 |
Mannkind Corporation |
Substituted diketopiperazine analogs for use as drug delivery agents
|
EP2405963B1
(en)
|
2009-03-11 |
2013-11-06 |
MannKind Corporation |
Apparatus, system and method for measuring resistance of an inhaler
|
BRPI1010600A2
(pt)
|
2009-05-15 |
2016-03-15 |
Novartis Ag |
aril piridina como inibidores de aldosterona sintase
|
CN102459247B
(zh)
|
2009-05-15 |
2014-09-17 |
诺华股份有限公司 |
作为醛固酮合酶抑制剂的苯并噁唑酮衍生物
|
SG176010A1
(en)
|
2009-05-28 |
2011-12-29 |
Novartis Ag |
Substituted aminobutyric derivatives as neprilysin inhibitors
|
KR101442897B1
(ko)
|
2009-05-28 |
2014-09-23 |
노파르티스 아게 |
네프릴리신 억제제로서의 치환된 아미노프로피온산 유도체
|
KR101875969B1
(ko)
|
2009-06-12 |
2018-07-06 |
맨카인드 코포레이션 |
한정된 비표면적을 갖는 디케토피페라진 마이크로입자
|
AU2010282250B2
(en)
*
|
2009-08-14 |
2015-11-12 |
Immunoforge Co., Ltd. |
Modified Vasoactive Intestinal Peptides
|
JP5784622B2
(ja)
|
2009-11-03 |
2015-09-24 |
マンカインド コーポレ−ション |
吸入活動をシミュレートするための装置及び方法
|
WO2011058082A1
(de)
|
2009-11-13 |
2011-05-19 |
Sanofi-Aventis Deutschland Gmbh |
Pharmazeutische zusammensetzung umfassend einen glp-1-agonisten und methionin
|
AR080669A1
(es)
|
2009-11-13 |
2012-05-02 |
Sanofi Aventis Deutschland |
Composicion farmaceutica que comprende un agonista de glp-1, una insulina y metionina
|
US8519134B2
(en)
|
2009-11-17 |
2013-08-27 |
Novartis Ag |
Aryl-pyridine derivatives as aldosterone synthase inhibitors
|
JO2967B1
(en)
|
2009-11-20 |
2016-03-15 |
نوفارتس ايه جي |
Acetic acid derivatives of carbamoyl methyl amino are substituted as new NEP inhibitors
|
WO2011064376A1
(en)
|
2009-11-30 |
2011-06-03 |
Novartis Ag |
Imidazole derivatives as aldosterone synthase inhibitors
|
WO2011123943A1
(en)
|
2010-04-09 |
2011-10-13 |
Mount Sinai Hospital |
Methods for treating disorders of the gastrointestinal tract using a glp-1 agonist
|
CN107129538B
(zh)
|
2010-04-27 |
2021-07-16 |
西兰制药公司 |
Glp-1受体激动剂和胃泌素的肽缀合物及其用途
|
ES2528496T3
(es)
|
2010-05-17 |
2015-02-10 |
Betta Pharmaceuticals Co., Ltd. |
Nuevos análogos de péptido similar a glucagón, composición, y métodos de uso
|
MX359281B
(es)
|
2010-06-21 |
2018-09-21 |
Mannkind Corp |
Sistema y metodos para suministrar un farmaco en polvo seco.
|
ES2606554T3
(es)
|
2010-08-30 |
2017-03-24 |
Sanofi-Aventis Deutschland Gmbh |
Uso de AVE0010 para la fabricación de un medicamento para el tratamiento de la diabetes mellitus de tipo 2
|
US8673974B2
(en)
|
2010-11-16 |
2014-03-18 |
Novartis Ag |
Substituted amino bisphenyl pentanoic acid derivatives as NEP inhibitors
|
US8877815B2
(en)
|
2010-11-16 |
2014-11-04 |
Novartis Ag |
Substituted carbamoylcycloalkyl acetic acid derivatives as NEP
|
MX345501B
(es)
|
2010-12-16 |
2017-02-02 |
Novo Nordisk As |
Composiciones solidas que comprenden agonista de glp-1 y sal del acido n-(8-(2-hidroxibenzoil)amino)caprilico.
|
CN103298456A
(zh)
*
|
2011-01-19 |
2013-09-11 |
诺沃—诺迪斯克有限公司 |
Glp-1颗粒和组合物
|
MX353285B
(es)
|
2011-04-01 |
2018-01-05 |
Mannkind Corp |
Paquete de blister para cartuchos farmaceuticos.
|
MX355361B
(es)
|
2011-04-12 |
2018-04-17 |
Novo Nordisk As |
Derivados de peptido 1 tipo glucagon (glp-1) doblemente acilados.
|
US9821032B2
(en)
|
2011-05-13 |
2017-11-21 |
Sanofi-Aventis Deutschland Gmbh |
Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin
|
CA2873553C
(en)
|
2011-06-06 |
2020-01-28 |
Phasebio Pharmaceuticals, Inc. |
Use of modified vasoactive intestinal peptides in the treatment of hypertension
|
WO2012174472A1
(en)
|
2011-06-17 |
2012-12-20 |
Mannkind Corporation |
High capacity diketopiperazine microparticles
|
BR112014004726A2
(pt)
|
2011-08-29 |
2017-04-04 |
Sanofi Aventis Deutschland |
combinação farmacêutica para uso no controle glicêmico em pacientes de diabetes tipo 2
|
TWI559929B
(en)
|
2011-09-01 |
2016-12-01 |
Sanofi Aventis Deutschland |
Pharmaceutical composition for use in the treatment of a neurodegenerative disease
|
CN103945859A
(zh)
|
2011-10-24 |
2014-07-23 |
曼金德公司 |
用于治疗疼痛的方法和组合物
|
WO2013064669A1
(en)
|
2011-11-03 |
2013-05-10 |
Zealand Pharma A/S |
Glp-1 receptor agonist peptide gastrin conjugates
|
CN104011064A
(zh)
|
2011-12-29 |
2014-08-27 |
诺沃—诺迪斯克有限公司 |
包含非成蛋白质性的氨基酸的二肽
|
HUE042757T2
(hu)
|
2012-03-22 |
2019-07-29 |
Novo Nordisk As |
Szállító szert tartalmazó készítmények és elõállításuk
|
MY171146A
(en)
|
2012-03-22 |
2019-09-27 |
Novo Nordisk As |
Compositions of glp-1 peptides and preparation thereof
|
EP2863895B1
(en)
|
2012-06-20 |
2021-04-14 |
Novo Nordisk A/S |
Tablet formulation comprising a peptide and a delivery agent
|
WO2014010586A1
(ja)
|
2012-07-10 |
2014-01-16 |
武田薬品工業株式会社 |
注射用製剤
|
WO2014012069A2
(en)
|
2012-07-12 |
2014-01-16 |
Mannkind Corporation |
Dry powder drug delivery systems and methods
|
AU2013295035B2
(en)
|
2012-07-23 |
2017-08-03 |
Zealand Pharma A/S |
Glucagon analogues
|
TWI608013B
(zh)
|
2012-09-17 |
2017-12-11 |
西蘭製藥公司 |
升糖素類似物
|
EP2911690A1
(en)
|
2012-10-26 |
2015-09-02 |
MannKind Corporation |
Inhalable influenza vaccine compositions and methods
|
UY35144A
(es)
|
2012-11-20 |
2014-06-30 |
Novartis Ag |
Miméticos lineales sintéticos de apelina para el tratamiento de insuficiencia cardiaca
|
TWI780236B
(zh)
|
2013-02-04 |
2022-10-11 |
法商賽諾菲公司 |
胰島素類似物及/或胰島素衍生物之穩定化醫藥調配物
|
NZ710574A
(en)
|
2013-02-14 |
2017-11-24 |
Novartis Ag |
Substituted bisphenyl butanoic phosphonic acid derivatives as nep (neutral endopeptidase) inhibitors
|
AU2014228415B2
(en)
|
2013-03-15 |
2018-08-09 |
Mannkind Corporation |
Microcrystalline diketopiperazine compositions and methods
|
KR102321339B1
(ko)
|
2013-07-18 |
2021-11-02 |
맨카인드 코포레이션 |
열-안정성 건조 분말 약제학적 조성물 및 방법
|
US9340582B2
(en)
|
2013-07-25 |
2016-05-17 |
Novartis Ag |
Bioconjugates of synthetic apelin polypeptides
|
WO2015013168A1
(en)
|
2013-07-25 |
2015-01-29 |
Novartis Ag |
Cyclic polypeptides for the treatment of heart failure
|
US11446127B2
(en)
|
2013-08-05 |
2022-09-20 |
Mannkind Corporation |
Insufflation apparatus and methods
|
US9988429B2
(en)
|
2013-10-17 |
2018-06-05 |
Zealand Pharma A/S |
Glucagon analogues
|
RS57632B1
(sr)
|
2013-10-17 |
2018-11-30 |
Zealand Pharma As |
Acilovani analozi glukagona
|
AU2014345569B2
(en)
|
2013-11-06 |
2020-08-13 |
Zealand Pharma A/S |
GIP-GLP-1 dual agonist compounds and methods
|
EP3066117B1
(en)
|
2013-11-06 |
2019-01-02 |
Zealand Pharma A/S |
Glucagon-glp-1-gip triple agonist compounds
|
AU2015205624A1
(en)
|
2014-01-09 |
2016-07-14 |
Sanofi |
Stabilized pharmaceutical formulations of insulin analogues and/or insulin derivatives
|
SG11201604708VA
(en)
|
2014-01-09 |
2016-07-28 |
Sanofi Sa |
Stabilized glycerol free pharmaceutical formulations of insulin analogues and/or insulin derivatives
|
CN105899190B
(zh)
|
2014-01-09 |
2022-06-14 |
赛诺菲 |
门冬胰岛素的稳定化药物制剂
|
US10307464B2
(en)
|
2014-03-28 |
2019-06-04 |
Mannkind Corporation |
Use of ultrarapid acting insulin
|
US11052132B2
(en)
|
2014-05-08 |
2021-07-06 |
Phasebio Pharmaceuticals, Inc. |
Methods and compositions for treating cystic fibrosis
|
US10561806B2
(en)
|
2014-10-02 |
2020-02-18 |
Mannkind Corporation |
Mouthpiece cover for an inhaler
|
EP3985016A1
(en)
|
2014-10-29 |
2022-04-20 |
Zealand Pharma A/S |
Gip agonist compounds and methods
|
PL3229828T3
(pl)
|
2014-12-12 |
2023-07-31 |
Sanofi-Aventis Deutschland Gmbh |
Formulacja o ustalonym stosunku insuliny glargine/liksysenatydu
|
CN105820233B
(zh)
*
|
2015-01-04 |
2021-06-15 |
甘李药业股份有限公司 |
一种胰岛素衍生物的制备方法
|
CA2972871A1
(en)
|
2015-01-23 |
2016-07-28 |
Novartis Ag |
Synthetic apelin fatty acid conjugates with improved half-life
|
EP3256151B1
(en)
|
2015-02-09 |
2020-08-05 |
Phasebio Pharmaceuticals, Inc. |
Methods and compositions for treating muscle disease and disorders
|
TWI748945B
(zh)
|
2015-03-13 |
2021-12-11 |
德商賽諾菲阿凡提斯德意志有限公司 |
第2型糖尿病病患治療
|
TW201705975A
(zh)
|
2015-03-18 |
2017-02-16 |
賽諾菲阿凡提斯德意志有限公司 |
第2型糖尿病病患之治療
|
EP3283507B8
(en)
|
2015-04-16 |
2019-11-13 |
Zealand Pharma A/S |
Acylated glucagon analogue
|
JOP20190086A1
(ar)
|
2016-10-21 |
2019-04-18 |
Novartis Ag |
مشتقات نافثيريدينون جديدة واستخدامها في معالجة عدم انتظام ضربات القلب
|
ES2979184T3
(es)
|
2016-12-09 |
2024-09-24 |
Zealand Pharma As |
Agonistas duales de glp-1/glp-2 acilados
|
AR112480A1
(es)
|
2017-08-24 |
2019-10-30 |
Novo Nordisk As |
Composiciones de glp-1 y sus usos
|
KR102647171B1
(ko)
|
2018-02-02 |
2024-03-15 |
노보 노르디스크 에이/에스 |
Glp-1 작용제 및 n-(8-(2-하이드록시벤조일)아미노)카프릴산의 염을 포함하는 고형 조성물
|
UY38072A
(es)
|
2018-02-07 |
2019-10-01 |
Novartis Ag |
Compuestos derivados de éster butanoico sustituido con bisfenilo como inhibidores de nep, composiciones y combinaciones de los mismos
|
WO2020110008A1
(en)
|
2018-11-27 |
2020-06-04 |
Novartis Ag |
Cyclic pentamer compounds as proprotein convertase subtilisin/kexin type 9 (pcsk9) inhibitors for the treatment of metabolic disorder
|
UY38485A
(es)
|
2018-11-27 |
2020-06-30 |
Novartis Ag |
Compuestos tetrámeros cíclicos como inhibidores de proproteína convertasa subtilisina/kexina tipo 9 (pcsk9), método de tratamiento, uso y su preparación
|
EP3887388A1
(en)
|
2018-11-27 |
2021-10-06 |
Novartis AG |
Cyclic peptides as proprotein convertase subtilisin/kexin type 9 (pcsk9) inhibitors for the treatment of metabolic disorders
|
GB201917723D0
(en)
*
|
2019-12-04 |
2020-01-15 |
Nv Rose Llc |
Stable liquid formulations of glucagon-like peptide 1 or analogues thereof
|
AU2021208601A1
(en)
|
2020-02-18 |
2022-07-28 |
Novo Nordisk A/S |
Glp-1 compositions and uses thereof
|
WO2023084449A1
(en)
|
2021-11-12 |
2023-05-19 |
Novartis Ag |
Diaminocyclopentylpyridine derivatives for the treatment of a disease or disorder
|
AR127698A1
(es)
|
2021-11-23 |
2024-02-21 |
Novartis Ag |
Derivados de naftiridinona para el tratamiento de una enfermedad o un trastorno
|