WO2017070633A2 - Evolved cas9 proteins for gene editing - Google Patents

Abstract

Some aspects of this disclosure provide strategies, systems, reagents, methods, and kits that are useful for enginerring Cas9 and Cas9 variants that have increased activity on target sequences that do not contain the canonical PAM sequence. In some embodiments, fusion proteins comprising such Cas9 variants and nucleic acid editing domains, e.g., deaminase domains, are provided.

Description

EVOLVED CAS9 PROTEINS FOR GENE EDITING

RELATED APPLICATIONS

[0001] This application claims priority under 35 U.S.C. § 119(e) to U.S. provisional patent applications, U.S. S.N. 62/245,828 filed October 23, 2015, U.S. S.N. 62/279,346 filed January 15, 2016, U.S. S.N. 62/311,763 filed March 22, 2016, U.S. S.N. 62/322,178 filed April 13, 2016, U.S. S.N. 62/357,352 filed June 30, 2016, U.S. S.N. 62/370,700 filed August 3, 2016, U.S. S.N. 62/398,490 filed September 22, 2016, U.S. S.N. 62/408,686 filed October 14, 2016, and U.S. S.N. 62/357,332 filed June 30, 2016; each of which is incorporated herein by reference

BACKGROUND OF THE INVENTION

[0002] Targeted editing of nucleic acid sequences, for example, the targeted cleavage or the targeted introduction of a specific modification into genomic DNA, is a highly promising approach for the study of gene function and also has the potential to provide new therapies for human genetic diseases.¹ An ideal nucleic acid editing technology possesses three characteristics: (1) high efficiency of installing the desired modification; (2) minimal off-target activity; and (3) the ability to be programmed to edit precisely any site in a given nucleic acid, e.g., any site within the human genome.² Current genome engineering tools, including engineered zinc finger nucleases (ZFNs),³ transcription activator like effector nucleases (TALENs),⁴ and most recently, the RNA-guided DNA endonuclease Cas9,⁵ effect sequence-specific DNA cleavage in a genome. This programmable cleavage can result in mutation of the DNA at the cleavage site via non-homologous end joining (NHEJ) or replacement of the DNA surrounding the cleavage site via homology-directed repair (HDR).⁶'⁷

[0003] One drawback of the current technologies is that both NHEJ and HDR are stochastic processes that typically result in modest gene editing efficiencies as well as unwanted gene alterations that can compete with the desired alteration.⁸ Since many genetic diseases in principle can be treated by effecting a specific nucleotide change at a specific location in the genome (for example, a C to T change in a specific codon of a gene associated with a disease),⁹ the development of a programmable way to achieve such precise gene editing would represent both a powerful new research tool, as well as a potential new approach to gene editing-based human therapeutics.

[0004] Another drawback of current genome engineering tools is that they are limited with respect to the DNA sequences that can be targeted. When using ZNFs or TALENS, a new protein must be generated for each individual target sequence. While Cas9 can be targeted to virtually any target sequence by providing a suitable guide RNA, Cas9 technology is still limited with respect to the sequences that can be targeted by a strict requirement for a protospacer-adj acent motif (PAM), typically of the nucleotide sequence 5'-NGG-3', that must be present immediately adjacent to the 3 '-end of the targeted DNA sequence in order for the Cas9 protein to bind and act upon the target sequence. The PAM requirement thus limits the sequences that can be efficiently targeted by Cas9 proteins.

SUMMARY OF THE INVENTION

[0005] Significantly, 80-90% of protein mutations responsible for human disease arise from the substitution, deletion, or insertion of only a single nucleotide.⁶ Most current strategies for single-base gene correction include engineered nucleases (which rely on the creation of double-strand breaks, DSBs, followed by stochastic, inefficient homology- directed repair, HDR), and DNA-RNA chimeric oligonucleotides.²² The latter strategy involves the design of a RNA/DNA sequence to base pair with a specific sequence in genomic DNA except at the nucleotide to be edited. The resulting mismatch is recognized by the cell's endogenous repair system and fixed, leading to a change in the sequence of either the chimera or the genome. Both of these strategies suffer from low gene editing efficiencies and unwanted gene alterations, as they are subject to both the stochasticity of HDR and the competition between HDR and non-homologous end-joining, NHEJ.^23-25 HDR efficiencies vary according to the location of the target gene within the genome,²⁶ the state of the cell cycle,²⁷ and the type of cell/tissue.²⁸ The development of a direct, programmable way to install a specific type of base modification at a precise location in genomic DNA with enzyme-like efficiency and no stochasticity therefore represents a powerful new approach to gene editing-based research tools and human therapeutics.

[0006] The clustered regularly interspaced short palindromic repeat (CRISPR) system is a recently discovered prokaryotic adaptive immune system¹⁰ that has been modified to enable robust and general genome engineering in a variety of organisms and cell lines.¹¹ CRISPR-Cas (CRISPR-associated) systems are protein-RNA complexes that use an RNA molecule (sgRNA) as a guide to localize the complex to a target DNA sequence via base- pairing.¹² In the natural systems, a Cas protein then acts as an endonuclease to cleave the targeted DNA sequence.¹³ The target DNA sequence must be both complementary to the sgRNA and also contain a "protospacer-adj acent motif (PAM) at the 3 '-end of the complementary region in order for the system to function.¹⁴ The requirement for a PAM sequence limits the use of Cas9 technology, since not all desired targeted sequences include a PAM sequence at the 3 '-end and thus cannot efficiently be targeted by wild-type Cas9 proteins.

[0007] Provided herein are novel Cas9 variants that exhibit activity on target sequences that do not include the canonical PAM sequence (5'-NGG-3', where N is any nucleotide) at the 3 '-end. Such Cas9 variants are not restricted to target sequences that include the canonical PAM sequence at the 3 '-end.

[0008] Among the known Cas proteins, Streptococcus pyogenes Cas9 has been mostly widely used as a tool for genome engineering.¹⁵ This Cas9 protein is a large, multi- domain protein containing two distinct nuclease domains. Point mutations can be introduced into Cas9 to abolish nuclease activity, resulting in a dead Cas9 (dCas9) that still retains its ability to bind DNA in a sgRNA-programmed manner.¹⁶In principle, such Cas9 variants, when fused to another protein or domain, can target that protein to virtually any DNA sequence simply by co-expression with an appropriate sgRNA. Thus, this disclosure also comtemplates fusion proteins comprising such Cas9 variants and a DNA modifying domain {e.g., a deaminase, a nuclease, a nickase, a recombinase, a methyltransferase, a methylase, an acetylase, an acetyltransferase, a transcriptional activator, or a transcriptional repressor domain), as well as the use of such fusion proteins in correcting mutations in a genome {e.g., the genome of a human subject) that are associated with disease, or generating mutations in a genome {e.g., the human genome) to decrease or prevent expression of a gene.

[0009] In some embodiments, any of the Cas9 proteins provided herein may be fused to a protein that has an enzymatic activity. In some embodiments, the enzymatic activity modifies a target DNA. In some embodiments, the enzymatic activity is nuclease activity, methyltransferase activity, demethylase activity, DNA repair activity, DNA damage activity, deamination activity, dismutase activity, alkylation activity, depurination activity, oxidation activity, pyrimidine dimer forming activity, integrase activity, transposase activity, recombinase activity, polymerase activity, ligase activity, helicase activity, photolyase activity or glycosylase activity. In some cases, the enzymatic activity is nuclease activity. In some cases, the nuclease activity introduces a double strand break in the target DNA. In some cases, the enzymatic activity modifies a target polypeptide associated with the target DNA. In some cases, the enzymatic activity is methyltransferase activity, demethylase activity, acetyltransferase activity, deacetylase activity, kinase activity, phosphatase activity, ubiquitin ligase activity, deubiquitinating activity, adenylation activity, deadenylation activity,

SUMOylating activity, deSUMOylating activity, ribosylation activity, deribosylation activity, mynstoylation activity or demyristoylation activity. In some cases, the target polypeptide is a histone and the enzymatic activity is methyltransferase activity, demethylase activity, acetyltransferase activity, deacetylase activity, kinase activity, phosphatase activity, ubiquitin ligase activity or deubiquitinating activity.

[0010] In some embodiments, any of the Cas9 proteins provided herein may be fused to a protein that has an enzymatic activity. In some embodiments, the enzymatic activity modifies a polypeptide associated with DNA (e.g. a histone). In some embodiments, the enzymatic activity is methyltransferase activity, demethylase activity, acetyltransferase activity, deacetylase activity, kinase activity, phosphatase activity, ubiquitin ligase activity (i.e., ubiquitination activity), deubiquitinating activity, adenylation activity, deadenylation activity, SUMOylating activity, deSUMOylating activity, ribosylation activity, deribosylation activity, myristoylation activity, demyristoylation activity glycosylation activity (e.g., from O-GlcNAc transferase) or deglycosylation activity. The enzymatic activities listed herein catalyze covalent modifications to proteins. Such modifications are known in the art to alter the stability or activity of the target protein (e.g., phosphorylation due to kinase activity can stimulate or silence protein activity depending on the target protein). Of particular interest as protein targets are histones. Histone proteins are known in the art to bind DNA and form complexes known as nucleosomes. Histones can be modified (e.g., by methylation, acetylation, ubuitination, phosphorylation) to elicit structural changes in the surrounding DNA, thus controlling the accessibility of potentially large portions of DNA to interacting factors such as transcription factors, polymerases and the like. A single histone can be modified in many different ways and in many different combinations (e.g., trimethylation of lysine 27 of histone 3, H3K27, is associated with DNA regions of repressed transcription while trimethylation of lysine 4 of histone 3, H3K4, is associated with DNA regions of active transcription). Thus, a site-directed modifying polypeptide with hi stone-modifying activity finds use in the site specific control of DNA structure and can be used to alter the histone modification pattern in a selected region of target DNA. Such methods find use in both research and clinical applications.

[0011] In some embodiments, the deaminase domain catalyzes the removal of an amine group from a molecule. In further embodiments, cytidine deaminase domains deaminate cytosine to yield uracil. In other embodiments, the nuclease domain has enzymatic activity and may cleave phosphodiester bonds between the nucleotide subunits of nucleic acids. In some embodiments, recombinase domains, which recombine specific sequences of DNA, may be used to manipulate the structure of genomes and to control gene expression. In further embodiments, methylase domains may be utilized to methylate their respective substrates, while acetylase domains may be used to acetylate their respective substrates. In other embodiments, acetyltransferase domains may be used to transfer an acetyl group. Examples of acetyltransferase molecules include, but are not limited to, histone acetyltransferases (e.g., CBP histone acetyltransferase), choline acetyltransferase,

chloramphenicol acetytransferase, serotonic N-acetyltransferase, NatA acetyltransferase, and NatB acetyltransferase. The disclosure also contemplates transcriptional activator and transcriptional repressor domains. Transcriptional activator domains are regions of a transcription factor which may activate transcription from a promoter through an interaction or multiple interactions with a DNA binding domain, general transcription factors, and RNA polymerase. Transcriptional repressor domins are regions of a transcription factor which may repress transcription from a protomer through an interaction or multiple interactions with a DNA binding domain, general transcription factors, and RNA polymerase.

[0012] The potential of the Cas9 system for genome engineering is immense. Its unique ability to bring proteins to specific sites in a genome programmed by the sgRNA can be developed into a variety of site-specific genome engineering tools beyond nucleases, including transcriptional activators, transcriptional repressors, hi stone-modifying proteins, integrases, deaminases, and recombinases.¹¹ Some of these potential applications have recently been implemented through dCas9 fusions with transcriptional activators to afford RNA-guided transcriptional activators,¹⁷'¹⁸ transcriptional repressors,¹⁶'¹⁹'²⁰ and chromatin modification enzymes.²¹ Simple co-expression of these fusions with a variety of sgRNAs results in specific expression of the target genes. These seminal studies have paved the way for the design and construction of readily programmable sequence-specific effectors for the precise manipulation of genomes.

[0013] Some aspects of this disclosure provide strategies, systems, proteins, nucleic acids, compositions, cells, reagents, methods, and kits that are useful for the targeted binding, editing, and/or cleaving of nucleic acids, including editing a single site within a subject's genome, e.g., a human subject's genome. In some embodiments, recombinant Cas9 proteins are provided that comprise at least one, at least two, at least three, at least four, at least five, at least six, at least seven, at least eight, at least nine, or at least ten mutations as compared to a naturally occurring Cas9 protein, and that exhibit activity on target sequences that do not include the canonical PAM (5 '-NGG-3 ', where N is any nucleotide) at the 3 '-end. Examples of such Cas9 protein mutations are given in Tables 3, 5, 8, and 9. In some embodiments, fusion proteins of Cas9 and nucleic acid editing enzymes or enzymatic domains, e.g., deaminase domains, are provided. In some embodiments, methods for targeted nucleic acid binding, editing, and/or cleaving are provided. In some embodiments, reagents and kits for the generation of targeted nucleic acid binding, editing, and/or cleaving proteins, e.g., fusion proteins of Cas9 variants and nucleic acid editing enzymes or domains, are provided.

[0014] Some aspects of this disclosure provide recombinant Cas9 proteins comprising an amino acid sequence that is at least 80%, at least 85%>, at least 90%, at least 92%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or at least 99.5% identical to the amino acid sequence of Cas9 as provided by any of the sequences set forth in SEQ ID NOs:

9- 262, wherein the amino acid sequence of the Cas9 protein comprises at least one, at least two, at least three, at least four, at least five, at least six, or at least seven mutations in an amino acid residue selected from the group consisting of amino acid residues 122, 137, 182, 262, 294, 409, 480, 543, 660, 694, 1219, and 1329 of S. pyogenes Cas9 having the amino acid sequence provided in SEQ ID NO: 9, or in a corresponding amino acid residue in any of the amino acid sequences provided in SEQ ID NOs: 10-262. In some embodiments, the recombinant Cas9 protein comprises a RuvC and an HNH domain. In some embodiments, the amino acid sequence of the recombinant Cas9 protein is not identical to the amino acid sequence of a naturally occurring Cas9 protein. In some embodiments, the amino acid sequence of the Cas9 protein comprises at least one, at least two, at least three, at least four, at least five, at least six, or at least seven mutations selected from the group consisting of X262T, X294R, X409I, X480K, X543D, X694I, and X1219V of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262, wherein X represents any amino acid. In some embodiments, the amino acid sequence of the Cas9 protein comprises at least one, at least two, at least three, at least four, at least five, at least six, or at least seven mutations selected from the group consisting of A262T, K294R, S409I, E480K, E543D, M694I, and E1219V of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262.

[0015] Other aspects of this disclosure provide recombinant Cas9 proteins comprising an amino acid sequence that is at least 80%>, at least 85%>, at least 90%, at least 92%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or at least 99.5% identical to the amino acid sequence of Cas9 as provided by any of the sequences set forth in SEQ ID NOs:

10- 262, wherein the amino acid sequence of the Cas9 protein comprises at least one, at least two, at least three, at least four, at least five, at least six, or at least seven mutations in an amino acid residue selected from the group consisting of amino acid residues 262, 267, 294, 405, 409, 480, 543, 694, 1219, 1224, 1256, and 1362 of the amino acid sequence provided in SEQ ID NO: 9, or in a corresponding amino acid residue in any of the amino acid sequences provided in SEQ ID NOs: 10-262; and wherein the amino acid sequence of the recombinant Cas9 protein is not identical to the amino acid sequence of a naturally occurring Cas9 protein. In some embodiments, the Cas9 protein comprises a RuvC and an HNH domain. In some embodiments, the amino acid sequence of the Cas9 protein comprises at least one, at least two, at least three, at least four, at least five, at least six, or at least seven mutations selected from the group consisting of X262T, X267G, X294R, X405I, X409I, X480K, X543D, X694I, X1219V, X1224K, and X1256K of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10- 262, wherein X represents any amino acid. In some embodiments, the amino acid sequence of the Cas9 protein comprises at least one, at least two, at least three, at least four, at least five, at least six, or at least seven mutations selected from the group consisting of A262T, S267G, K294R, F405I, S409I, E480K, E543D, M694I, E1219V, N1224K, and Q1256K of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in in SEQ ID NOs: 10-262.

[0016] It should be appreciated that any of the amino acid mutaions described herein,

(e.g., A262T) from a first amino acid residue (e.g., A) to a second amino acid residue (e.g., T) may also include mutations from the first amino acid residue to an amino acid residue that is similar to (e.g., conserved) the second amino acid residue. For example, a mutation of an alanine to a threonine (e.g., a A262T mutation) may also be a mutation from an alanine to an amino acid that is similar in size and chemical properties to a threonine, for example, serine. Additional similar amino acid pairs include, but are not limited to, the following:

phenylalanine and tyrosine; asparagine and glutamine; methionine and cysteine; aspartic acid and glutamic acid; and arginine and lysine. The skilled artisan would recognize that such conservative amino acid substitutions will likely have minor effects on protein structure and are likely to be well tolerated without compromising function. In some embodiments, any amino of the amino acid mutations provided herein from one amino acid to a threonine may be an amino acid mutation to a serine. In some embodiments, any amino of the amino acid mutations provided herein from one amino acid to an arginine may be an amino acid mutation to a lysine. In some embodiments, any amino of the amino acid mutations provided herein from one amino acid to an isoleucine, may be an amino acid mutation to an alanine, valine, methionine, or leucine. In some embodiments, any amino of the amino acid mutations provided herein from one amino acid to a lysine may be an amino acid mutation to an arginine. In some embodiments, any amino of the amino acid mutations provided herein from one amino acid to an aspartic acid may be an amino acid mutation to a glutamic acid or asparigine. In some embodiments, any amino of the amino acid mutations provided herein from one amino acid to a valine may be an amino acid mutation to an alanine, isoleucine, methionine, or leucine. In some embodiments, any amino of the amino acid mutations provided herein from one amino acid to a glycine may be an amino acid mutation to an alanine. It should be appreciated, however, that additional conserved amino acid residues would be recognized by the skilled artisan and any of the amino acid mutations to other conserved amino acid residues are also within the scope of this disclosure.

[0017] In some embodiments, the Cas9 protein is a Cas9 domain of a fusion protein.

In some embodiments, the amino acid sequence of the Cas9 protein comprises an X1219V mutation of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262, wherein X represents any amino acid. In some embodiments, the mutation is X1219A, X1219I, X1219M, or X1219L.

[0018] In some embodiments, the amino acid sequence of the Cas9 protein comprises an E1219V mutation of the amino acid sequence provided in SEQ ID NO: 9, or a

corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10- 262. In some embodiments, the mutation is E1219A, E1219I, E1219M or E1219L.

[0019] In some embodiments, the amino acid sequence of the Cas9 protein comprises an X480K mutation of the amino acid sequence provided in SEQ ID NO: 9, or a

corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10- 262, wherein X represents any amino acid. In some embodiments, the mutation is X480R.

[0020] In some embodiments, the amino acid sequence of the Cas9 protein comprises an E480K mutation of the amino acid sequence provided in SEQ ID NO: 9, or a

corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10- 262. In some embodiments, the mutation is E480R.

[0021] In some embodiments, the amino acid sequence of the Cas9 protein comprises an X543D mutation of the amino acid sequence provided in SEQ ID NO: 9, or a

corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10- 262, wherein X represents any amino acid. In some embodiments, the mutation isX543N.

[0022] In some embodiments, the amino acid sequence of the Cas9 protein comprises an E543D mutation of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10- 262. In some embodiments, the mutation is E543N.

[0023] In some embodiments, the amino acid sequence of the Cas9 protein comprises the mutations X480K, X543D, and X1219V of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262, wherein X represents any amino acid.

[0024] In some embodiments, the amino acid sequence of the Cas9 protein comprises the mutations X262T, X409I, X480K, X543D, X694I, and X1219V of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262, wherein X represents any amino acid.

[0025] In some embodiments, the amino acid sequence of the Cas9 protein comprises the mutations X294R, X480K, X543D, X1219V, X1256K, and X1362P of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262, wherein X represents any amino acid.

[0026] In some embodiments, the amino acid sequence of the Cas9 protein comprises the mutations X294R, X480K, X543D, X1219V, and X1256K of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262, wherein X represents any amino acid.

[0027] In some embodiments, the amino acid sequence of the Cas9 protein comprises the mutations X267G, X294R, X480K, X543D, X1219V, X1224K, and X1256K of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262, wherein X represents any amino acid.

[0028] In some embodiments, the amino acid sequence of the Cas9 protein comprises the mutations X262T, X405I, X409I, X480K, X543D, X694I, and X1219V of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262, wherein X represents any amino acid.

[0029] In some embodiments, the amino acid sequence of the Cas9 protein comprises the mutations E480K, E543D, and E1219V of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262.

[0030] In some embodiments, the amino acid sequence of the Cas9 protein comprises the mutations A262T, S409I, E480K, E543D, M694I, and E1219V of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262.

[0031] In some embodiments, the amino acid sequence of the Cas9 protein comprises the mutations K294R, E480K, E543D, E1219V, Q1256K, and L1362P of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262.

[0032] In some embodiments, the amino acid sequence of the Cas9 protein comprises the mutations K294R, E480K, E543D, E1219V, and Q1256K of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262.

[0033] In some embodiments, the amino acid sequence of the Cas9 protein comprises the mutations S267G, K294R, E480K, E543D, E1219V, N1224K, and Q1256K of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262.

[0034] In some embodiments, the amino acid sequence of the Cas9 protein comprises the mutations A262T, F405I, S409I, E480K, E543D, M694I, and E1219V of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262.

[0035] The HNH nuclease domain of Cas9 functions to cleave the DNA strand complementary to the guide RNA (gRNA). Its active site consists of a ββα-metal fold, and its histidine 840 activates a water molecule to attack the scissile phosphate, which is more electrophilic due to coordination with a magnesium ion, resulting in cleavage of the the 3 '-5' phosphate bond. In some embodiments, the amino acid sequence of the HNH domain is at least 80%, at least 85%, at least 90%, at least 92%, at least 95%, at least 96%, at least 97%, at least 98%), at least 99%, or at least 99.5% identical to the amino acid sequence of the HNH domain of any of SEQ ID NOs: 9-262. In some embodiments, the amino acid sequence of the HNH domain is identical to the amino acid sequence of the HNH domain of any of SEQ ID NOs: 9-262.

[0036] The RuvC domain of Cas9 cleaves the non-target DNA strand. It is encoded by sequentially disparate sites which interact in the tertiary structure to form the RuvC cleaveage domain and consists of an RNase H fold structure. In some embodiments, the amino acid sequence of the RuvC domain is at least 80%, at least 85%, at least 90%, at least 92%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or at least 99.5% identical to the amino acid sequence of the RuvC domain of any of SEQ ID NOs: 9-262. In some embodiments, the amino acid sequence of the RuvC domain is identical to the amino acid sequence of the RuvC domain of any of SEQ ID NOs: 9-262.

[0037] In some embodiments, the Cas9 protein comprises one or more mutations that affects (e.g., inhibits) the ability of Cas9 to cleave one or both strands of a DNA duplex. In some embodiments, the Cas9 protein comprises a DIOA and/or a H840A mutation of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262. In some embodiments, the Cas9 protein comprises a DIOXi and/or a H840X₂ mutation of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262, wherein Xi is any amino acid except for D, and X₂ is any amino acid except for H. In some embodiments, the Cas9 protein comprises an DIOA mutation of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262. In some embodiments, the Cas9 protein comprises an H at amino acid residue 840 of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding residue in any of the amino acid sequences provided in SEQ ID NOs: 10-262. In some embodiments, the Cas9 protein comprises an H840A mutation of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262. In some embodiments, the Cas9 protein comprises a D at amino acid residue 10 of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding residue in any of the amino acid sequences provided in SEQ ID NOs: 10-262.

[0038] In some embodiments, the Cas9 protein of the present disclosure exhibits activity, for example, increased binding, on a target sequence that does not include the canonical PAM sequence (5'-NGG-3') at its 3 '-end as compared to Streptococcus pyogenes Cas9 as provided by SEQ ID NO: 9.

[0039] Some aspects of this disclosure provide recombinant Cas9 proteins comprising an amino acid sequence that is at least 90% identical to the amino acid sequence of

Streptococcus pyogenes Cas9 as provided by SEQ ID NO: 9 wherein the amino acid sequence of the Cas9 protein comprises at least one, at least two, at least three, at least four, at least five, at least six, or at least seven mutations selected from the group consisting of amino acid residues 262, 267, 294, 405, 409, 480, 543, 694, 1219, 1224, 1256, and 1362 of the amino acid sequence provided in SEQ ID NO: 9, wherein the amino acid sequence of the recombinant Cas9 protein is not identical to the amino acid sequence of a naturally occurring Cas9 protein, and wherein the recombinant Cas9 protein exhibits increased activity on a target sequence that does not comprise the canonical PAM sequence (5'-NGG-3') at its 3' end as compared to Streptococcus pyogenes Cas9 as provided in SEQ ID NO: 9. In some embodiments, the Streptococcus pyogenes Cas9 comprises a RuvC and an HNH domain. In other embodiments, the Cas9 protein comprises at least one, at least two, at least three, at least four, at least five, at least six, or at least seven mutations selected from the group consisting of amino acid residues 122, 137, 182, 262, 294, 409, 480, 543, 660, 694, 1219, and 1329 of the amino acid sequence provided in SEQ ID NO: 9

[0040] As one example, the Cas9 protein may exhibit increased binding to the target sequence, may exhibit increased nuclease activity at the target sequence, or may exhibit an increase in other activities, depending on whether the Cas 9 protein is fused to an additional domain, such as an enzyme that has enzymatic activity. In some embodiments, the enzymatic activity modifies a target DNA. In some embodiments, the enzymatic activity is nuclease activity, methyltransferase activity, demethylase activity, DNA repair activity, DNA damage activity, deamination activity, dismutase activity, alkylation activity, depurination activity, oxidation activity, pyrimidine dimer forming activity, integrase activity, transposase activity, recombinase activity, polymerase activity, ligase activity, helicase activity, photolyase activity or glycosylase activity. In some cases, the enzymatic activity is nuclease activity. In some cases, the nuclease activity introduces a double strand break in the target DNA. In some cases, the enzymatic activity modifies a target polypeptide associated with the target DNA. In some cases, the enzymatic activity is methyltransferase activity, demethylase activity, acetyltransferase activity, deacetylase activity, kinase activity, phosphatase activity, ubiquitin ligase activity, deubiquitinating activity, adenylation activity, deadenylation activity,

SUMOylating activity, deSUMOylating activity, ribosylation activity, deribosylation activity, myristoylation activity or demyristoylation activity. In some cases, the target polypeptide is a histone and the enzymatic activity is methyltransferase activity, demethylase activity, acetyltransferase activity, deacetylase activity, kinase activity, phosphatase activity, ubiquitin ligase activity or deubiquitinating activity.

[0041] In some embodiments, any of the Cas9 protein is fused to a protein that has an enzymatic activity. In some embodiments, the enzymatic activity modifies a polypeptide associated with DNA (e.g. a histone). In some embodiments, the enzymatic activity is methyltransferase activity, demethylase activity, acetyltransferase activity, deacetylase activity, kinase activity, phosphatase activity, ubiquitin ligase activity (i.e., ubiquitination activity), deubiquitinating activity, adenylation activity, deadenylation activity, SUMOylating activity, deSUMOylating activity, ribosylation activity, deribosylation activity, myristoylation activity, demyristoylation activity glycosylation activity (e.g., from O-GlcNAc transferase) or deglycosylation activity. The enzymatic activities listed herein catalyze covalent modifications to proteins. Such modifications are known in the art to alter the stability or activity of the target protein (e.g., phosphorylation due to kinase activity can stimulate or silence protein activity depending on the target protein). Of particular interest as protein targets are histones. Histone proteins are known in the art to bind DNA and form complexes known as nucleosomes. Histones can be modified (e.g., by methylation, acetylation, ubuitination, phosphorylation) to elicit structural changes in the surrounding DNA, thus controlling the accessibility of potentially large portions of DNA to interacting factors such as transcription factors, polymerases and the like. A single histone can be modified in many different ways and in many different combinations (e.g., trimethylation of lysine 27 of histone 3, H3K27, is associated with DNA regions of repressed transcription while trimethylation of lysine 4 of histone 3, H3K4, is associated with DNA regions of active transcription). Thus, a site-directed modifying polypeptide with hi stone-modifying activity finds use in the site specific control of DNA structure and can be used to alter the histone modification pattern in a selected region of target DNA. Such methods find use in both research and clinical applications.

[0042] In some embodiments, the Cas9 protein exhibits activity on a target sequence having a 3' end that is not directly adjacent to, or does not have the canonical PAM sequence (5'-NGG-3 '), that is at least 2-fold, at least 3-fold, at least 5-fold, at least 10-fold, at least 50- fold, at least 100-fold, at least 500-fold, at least 1,000-fold, at least 5,000-fold, at least 10,000-fold, at least 50,000-fold, at least 100,000-fold, at least 500,000-fold, or at least 1,000,000-fold increased as compared to the activity of Streptococcus pyogenes Cas9 as provided by SEQ ID NO: 9 on the same target sequence.

[0043] In some embodiments, the 3 '-end of the target sequence is directly adjacent to an AGC, GAG, TTT, GTG, CAA CAC, GAT, TAA, ACG, CGA, or CGT sequence.

[0044] In some embodiments, the Cas9 protein activity is measured by a nuclease assay or a nucleic acid binding assay, which are known in the art and would be apparent to the skilled artisan. As provided herein, the Cas9 protein may be fused to one or more domains that confer an activity to the protein, such as a nucleic acid editing activity {e.g., deaminase activity or transcriptional activation activity), which may be measured {e.g., by a deaminase assay or transcriptional activation assay). In some embodiments, the Cas9 protein is fused to a deaminase domain and its activity may be measured using a deaminase assay. In some embodiments, the Cas9 protein is fused to a transcriptional activation domain and its activity may be measured using a transcriptional activation assay, for example, reporter activation assay where the reporter, e.g., GFP or luciferase, among others, is expressed in response to Cas9 binding to a target sequence.

[0045] In some embodiments, the amino acid sequence of the Cas9 protein comprises any of the mutations provided herein. For example, in some embodiments, the amino acid sequence of the Cas9 protein comprises at least one, at least two, at least three, at least four, at least five, at least six, or at least seven mutations selected from the group consisting of X262T, X267G, X294R, X405I, X409I, X480K, X543D, X694I, X1219V, X1224K,

X1256K, and X1362P of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10- 262, wherein X represents any amino acid. In other embodiments, the mutations may be A262T, S267G, K294R, F405I, S409I, E480K, E543D, M694I, E1219V, N1224K, Q1256K, and L1362P of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262.

[0046] In some embodiments, the amino acid sequence of the Cas9 protein comprises any of the mutations provided herein. For example, in some embodiments, the amino acid sequence of the Cas9 protein comprises at least one, at least two, at least three, at least four, at least five, at least six, or at least seven mutations selected from the group consisting of X262T, X294R, X409I, X480K, X543D, X694I, and X1219V of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262, wherein X represents any amino acid. In other

embodiments, the mutations may be A262T, K294R, S409I, E480K, E543D, M694I, or E1219V of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262.

[0047] In some embodiments, the amino acid sequence of the Cas9 protein comprises an X1219V mutation or an E1219V mutation of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262, wherein X represents any amino acid.

[0048] In some embodiments, the amino acid sequence of the Cas9 protein comprises an X480K mutation or an E480K mutation of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262, wherein X represents any amino acid.

[0049] In some embodiments, the amino acid sequence of the Cas9 protein comprises an X543D mutation or a E543D mutation of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262, wherein X represents any amino acid.

[0050] In some embodiments, the amino acid sequence of the Cas9 comprises the mutations X480K, X543D, and X1219V; or the mutations E480K, E543D, and E1219V of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262, wherein X represents any amino acid.

[0051] In some embodiments, the amino acid sequence of the Cas9 comprises the mutations X262T, X409I, X480K, X543D, X694I, and X1219V; or the mutations A262T, S409I, E480K, E543D, M694I, and E1219V of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262, wherein X represents any amino acid.

[0052] In some embodiments, the amino acid sequence of the Cas9 protein comprises the mutations X294R, X480K, X543D, X1219V, X1256K, and X1362P; or the mutations K294R, E480K, E543D, E1219V, Q1256K, and L1362P of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262, wherein X represents any amino acid.

[0053] In some embodiments, the amino acid sequence of the Cas9 protein comprises the mutations X294R, X480K, X543D, X1219V, and X1256K, or mutations K294R, E480K, E543D, E1219V, and Q1256K of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10- 262, wherein X represents any amino acid.

[0054] In some embodiments, the amino acid sequence of the Cas9 protein comprises the mutations X267G, X294R, X480K, X543D, X1219V, X1224K, and X1256K; or the mutations S267G, K294R, E480K, E543DE1219V, N1224K, and Q1256K of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262, wherein X represents any amino acid.

[0055] In some embodiments, the amino acid sequence of the Cas9 protein comprises the mutations X262T, X405I, X409I, X480K, X543D, X694I, and X1219V; or the mutations A262T, F405I, S409I, E480K, E543D, M694I, and E1219V of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262, wherein X represents any amino acid.

[0056] In some embodiments, the amino acid sequence of the HNH domain is at least

80%, at least 85%, at least 90%, at least 92%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or at least 99.5% identical to the amino acid sequence of the HNH domain of any of SEQ ID NOs: 9-262. In some embodiments, the amino acid sequence of the HNH domain is identical to the amino acid sequence of any of the HNH domains of SEQ ID NOs: 9-262.

[0057] In some embodiments, the amino acid sequence of the RuvC domain is at least

80%, at least 85%, at least 90%, at least 92%, at least 95%, at least 96%, at least 97%, at least 98%), at least 99%, or at least 99.5% identical to the amino acid sequence of the RuvC domain of any of SEQ ID NOs: 9-262. In some embodiments, the amino acid sequence of the RuvC domain is identical to the amino acid sequence of any of the RuvC domains of SEQ ID NOs: 9-262.

[0058] In some embodiments, the Cas9 protein comprises at D10A and/or a H840A mutation in the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262. In some embodiments, the Cas9 protein comprises a D10X₁ and/or a H840X₂ mutation of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262, wherein X₁ is any amino acid except for D, and wherein X₂ is any amino acid except for H. In some embodiments, the Cas9 protein comprises an D10A mutation of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262. In some embodiments, the Cas9 protein comprises an H at amino acid residue 840 of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding residue in any of the amino acid sequences provided in SEQ ID NOs: 10-262. In some embodiments, the Cas9 protein comprises an H840A mutation of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10- 262. In some embodiments, the Cas9 protein comprises an D at amino acid residue 10 of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding residue in any of the amino acid sequences provided in SEQ ID NOs: 10-262.

[0059] Some aspects of this disclosure provide fusion proteins comprising a Cas9 protein as provided herein that is fused to a second protein, thus forming a fusion protein. In some embodiments, the second protein is fused to the N-terminus of the Cas9 protein. In some embodiments, the second protein is fused to the C-terminus of the Cas9 protein. In some embodiments, the Cas9 domain and the effector domain are fused via a linker. The linker may be as simple as a covalent bond, or it may be a polymeric linker many atoms in length. In certain embodiments, the linker is a polpeptide or based on amino acids. In other embodiments, the linker is not peptide-like. In certain embodiments, the linker is a covalent bond (e.g., a carbon-carbon bond, disulfide bond, carbon-heteroatom bond, etc.). In certain embodiments, the linker is a carbon-nitrogen bond of an amide linkage. In certain embodiments, the linker is a cyclic or acyclic, substituted or unsubstituted, branched or unbranched aliphatic or heteroaliphatic linker. In certain embodiments, the linker is polymeric (e.g., polyethylene, polyethylene glycol, polyamide, polyester, etc.). In certain embodiments, the linker comprises a monomer, dimer, or polymer of aminoalkanoic acid. In certain embodiments, the linker comprises an aminoalkanoic acid (e.g., glycine, ethanoic acid, alanine, beta-alanine, 3-aminopropanoic acid, 4-aminobutanoic acid, 5-pentanoic acid, etc.). In certain embodiments, the linker comprises a monomer, dimer, or polymer of aminohexanoic acid (Ahx). In certain embodiments, the linker is based on a carbocyclic moiety (e.g., cyclopentane, cyclohexane). In other embodiments, the linker comprises a polyethylene glycol moiety (PEG). In other embodiments, the linker comprises amino acids. In certain embodiments, the linker comprises a peptide. In certain embodiments, the linker comprises an aryl or heteroaryl moiety. In certain embodiments, the linker is based on a phenyl ring. The linker may included funtionalized moieties to facilitate attachment of a nucleophile (e.g., thiol, amino) from the peptide to the linker. Any electrophile may be used as part of the linker. Exemplary electrophiles include, but are not limited to, activated esters, activated amides, Michael acceptors, alkyl halides, aryl halides, acyl halides, and

isothiocyanates.

[0060] In some embodiments, the linker comprises a chemical group or molecule linking two molecules or moieties, e.g., two domains of a fusion protein, such as, for example, a nuclease-inactive Cas9 domain and a effector domain (e.g., a deaminase domain). In some embodiments, the linker comprises one or more amino acid resudues. For example, the limker may comprise at least 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 25, 30, 35, 40, 45, 50, or more amino acid residues. In some embodiments, the linker is 3, 9, 16, or 21 amino acids in length. In some embodiments, the linker comprises a (GGGGS)n (SEQ ID NO: 5), a (G)„, an (EAAAK)_n (SEQ ID NO: 6), a (GGS)„, an

SGSETPGTSESATPES (SEQ ID NO: 7) (also referred to as XTEN), or an (XP)_n motif, or a combination of any of these, wherein n is independently an integer between 1 and 30. In some embodiments, wherein the linker comprises a (GGS)₃ motif or a

SGSETPGTSESATPES (SEQ ID NO: 7) (XTEN) motif.

[0061] Some aspects of this disclosure provide fusion proteins comprising a Cas9 protein as provided herein that is fused to a second protein, thus forming a fusion protein. In some embodiments, the second protein is fused to the N-terminus of the Cas9 protein. In some embodiments, the second protein is fused to the C-terminus of the Cas9 protein. In some embodiments, the Cas9 domain and the effector domain are fused via a nuclear localization sequence (NLS), for example a NLS comprising the amino acid sequence PKKKRKV (SEQ ID NO: 299), MD SLLMNRRKFL YQFKNVRWAKGRRET YLC (SEQ ID NO: 300), or SPKKKRKVEAS (SEQ ID NO: 284). In some embodiments, a NLS may be combined with any of the linkers listed above.

[0062] In some embodiments, the effector domain comprises an enzymatic domain.

In some embodiments, the effector domain comprises a nuclease, a nickase, a recombinase, a deaminase, a methyltransferase, a methylase, an acetylase, an acetyltransferase, a

transcriptional activator, or a transcriptional repressor domain, which may have nuclease activity, nickase activity, recombinase activity, deaminase activity, methyltransferase activity, methylase activity, acetylase activity, acetyltransferase activity transcriptional activation activity or transcriptional repression activity, respectively. In some embodiments, the effector domain is a effector domain. In some embodiments, the effector domain is a deaminase domain. In some embodiments, the deaminase is a cytosine deaminase or a cytidine deaminase. In some embodiments, the deaminase is an apolipoprotein B mRNA- editing complex (APOBEC) family deaminase. In some embodiments, the deaminase is an APOBECl deaminase. In some embodiments, the deaminase is an APOBEC2 deaminase. In some embodiments, the deaminase is an APOBEC3 deaminase. In some embodiments, the deaminase is an APOBEC3 A deaminase. In some embodiments, the deaminase is an

APOBEC3D deaminase. In some embodiments, the deaminase is an APOBEC3E deaminase. In some embodiments, the deaminase is an APOBEC3F deaminase. In some embodiments, the deaminase is an APOBEC3G deaminase. In some embodiments, the deaminase is an APOBEC3H deaminase. In some embodiments, the deaminase is an APOBEC4 deaminase. In some embodiments, the deaminase is an activation-induced deaminase (AID). In some embodiments, the effector domain is at least 80%, at least 85%>, at least 90%, at least 92%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or at least 99.5% identical to the deaminase domain of any one of SEQ ID NOs: 263-281. In some embodiments, the deaminase is a cytidine deaminase. In some embodiments, the deaminase is an

apolipoprotein B mRNA-editing complex (APOBEC) family deaminase. In some embodiments, the deaminase is an APOBECl family deaminase. In some embodiments, the deaminase is an activation-induced cytidine deaminase (AID). In some embodiments, the deaminase is an ACF1/ASE deaminase. In some embodiments, the deaminase is an adenosine deaminase. In some embodiments, the deaminase is an AD AT family deaminase.

[0063] Some aspects of this disclosure provide fusion proteins comprising a Cas9 protein fused to a effector domain, e.g., a deaminase, and a uracil glycosylase inhibitor (UGI). Some aspects of this disclosure are based on the recognition that such fusion proteins may exhibit an increased nucleic acid editing efficiency as compared to fusion proteins not comprising an UGI domain. Domains such as the deaminase domains and UGI domains have been described and are within the scope of this disclosure. For example domains such as deaminase domains and UGI domains have been described in Provisional Application Nos. : 62/245,828, filed October 23, 2015, 62/279,346 filed January 15, 2016, 62/311,763 filed March 22, 2016, 62/322, 178 filed April 13, 2016, 62/357,352 filed June 30, 2016, 62/370,700 filed August 3, 2016, 62/398,490 filed September 22, 2016, and 62/408,686 filed October 14, 2016; the entire contents of each is incorporated by reference herein. It should be appreciated that the deaminase domains and UGI domains described in the foregoing references are within the scope of this disclosure and may be fused with any of the Cas9 proteisn provided herein.

[0064] In some embodiments, the effector domain of the fusion protein is a nuclease domain. In some embodiments, the nuclease domain is a Fokl DNA cleavage domain. In some embodiments, the fusion protein dimerizes. In certain embodiments, the dimer of the fusion protein is active. For example, two Fokl DNA cleavage domains may dimerize to cleave a nucleic acid.

[0065] In some embodiments, the Cas9 protein is fused to a second Cas9 protein. In some embodiments, the second Cas9 protein is the Cas9 protein of any one of claims 1-345. In some embodiments, the second Cas9 protein is fused to the N-terminus of the fusion protein. In some embodiments, the second Cas9 protein is fused to the C-terminus of the fusion protein. In some embodiments, the Cas9 protein and the second Cas9 protein are fused via a second linker. In some embodiments, the second linker comprises a (GGGGS)_n (SEQ ID NO: 5), a (G)„, an (EAAAK)_n (SEQ ID NO: 6), a (GGS)„, an SGSETPGTSESATPES (SEQ ID NO: 7), or an (XP)_n motif, or a combination of any of these, wherein n is independently an integer between 1 and 30. In some embodiments, the second linker comprises a (GGS)₃ motif.

[0066] Some aspects of this disclosure provide complexes comprising a Cas9 protein, or a Cas9 fusion protein as provided herein, and a guide RNA bound to the Cas9 protein, or the Cas9 fusion protein. [0067] In some embodiments, the target sequence is a DNA sequence. In some embodiments, the target sequence is a sequence in the genome of a mammal. In some embodiments, the target sequence is a sequence in the genome of a human. In some embodiments, the 3 '-end of the target sequence is not immediately adjacent to the canonical PAM sequence (5'-NGG-3').

[0068] Some aspects of this disclosure provide methods of using the Cas9 proteins, fusion proteins, or complexes provided herein. For example, some aspects of this disclosure provide methods comprising contacting a DNA molecule (a) with a Cas9 protein or a fusion protein as provided herein and a guide RNA, wherein the guide RNA is about 15-100 nucleotides long and comprises a sequence of at least 10 contiguous nucleotides that is complementary to a target sequence; or (b) with a Cas9 protein, a Cas9 fusion protein, or a Cas9 protein or fusion protein complex with a gRNA as provided herein. In some embodiments, the 3 '-end of the target sequence is not immediately adjacent to the canonical PAM sequence (5'-NGG-3'). In some embodiments, the 3 '-end of the target sequence is immediately adjacent to an AGC, GAG, TTT, GTG, or CAA sequence. In some

embodiments, the target DNA sequence comprises a sequence associated with a disease or disorder. In some embodiments, the target DNA sequence comprises a point mutation associated with a disease or disorder. In some embodiments, the activity of the Cas9 protein, the Cas9 fusion protein, or the complex results in correction of the point mutation. In some embodiments, the step of contacting is performed in vivo in a subject.

[0069] Some aspects of this disclosure provide kits comprising a nucleic acid construct, comprising (a) a nucleotide sequence encoding a Cas9 protein or a Cas9 fusion protein as provided herein; and (b) a heterologous promoter that drives expression of the sequence of (a). In some embodiments, the kit further comprises an expression construct encoding a guide RNA backbone, wherein the construct comprises a cloning site positioned to allow the cloning of a nucleic acid sequence identical or complementary to a target sequence into the guide RNA backbone.

[0070] Some aspects of this disclosure provide polynucleotides encoding any of the

Cas9 proteins, Cas9 fusion proteins, or guide RNA bound to the Cas9 protein or Cas9 fusion protein provided herein. Some aspects of this disclosure provide vectors comprising such polynucleotides. In some embodiments, the vector comprises a heterologous promoter driving expression of the polynucleotide.

[0071] Some aspects of this disclosure provide cells comprising any of the Cas9 proteins, fusion proteins, nucleic acid molecules, and/or a vectors as provided herein. [0072] The summary above is meant to illustrate, in a non-limiting manner, some of the embodiments, advantages, features, and uses of the technology disclosed herein. Other embodiments, advantages, features, and uses of the technology disclosed herein will be apparent from the Detailed Description, the Drawings, the Examples, and the Claims.

BRIEF DESCRIPTION OF THE DRAWINGS

[0073] Figure 1 shows the activity of wild-type Streptococcus pyogenes Cas9 on canonical PAM libraries and non-canonical PAM libraries.

[0074] Figure 2 shows the activity of exemplary evolved Cas9 clones on a PAM library after directed evolution.

[0075] Figure 3 shows a comparison of wild-type and evolved Cas9 in a mammalian

GFP activation assay.

[0076] Figures 4 A to 4B show the binding activity of Cas9 (pJH306) and evolved

Cas9 proteins with an 5'-NGG-3 ' PAM sequence using GFP as a readout. On 5'-NGG-3 ' PAMs, many of the evolved Cas9 proteins showed increased Cas9 binding activity relative to wild-type Cas9 based on an increase in GFP fluorescence signal. Figure 4A is a graph representing Cas9 binding activity as a function of % cells above the background

fluorescence. Figure 4B is a graph showing Cas9 binding activity as a function of mean fluorescence. Cas9 proteins used in these experiments were dCas9 proteins fused to a VPR transcriptional activator.

[0077] Figures 5A to 5B show the binding activity of wild type dCas9-VPR

(pJH306) and evolved dCas9-VPR proteins with an NNN PAM sequence using GFP as a readout. On a library of NNN PAMs, many of the evolved Cas9 proteins showed increased Cas9 binding activity relative to wild-type Cas9 based on an increase in GFP fluorescence signal. Figure 5A is a graph representing Cas9 binding activity as a function of % cells above background fluorescence. Figure 5B is a graph showing Cas9 binding activity as a function of mean fluorescence. Cas9 proteins used in these experiments were dCas9 proteins fused to VPR.

[0078] Figure 6 shows dCas9-VPR on all 64 PAM sequences as demonstrated by mean fluorescence on transfected cells gated by iRFP fluorescence. WT dCas9-VPR is pJH306.

[0079] Figure 7 shows in vitro cutting assay. On the gel, WT is wild-type Cas9 (SEQ

ID NO: 9), and 1 is Cas9 (SEQ ID NO: 9) with the E1219V mutation.

[0080] Figure 8 shows a Cas9 fusion protein that can be used to modulate PAM specificity. One possible configuration for a linked Cas9-dCas9 system that could be used for increasing Cas9 targeting to non-canonical PAMs is shown. dCas9 binding to 5'-NGG-3 ' or another PAM could localize Cas9 to an area close to target 2. This localization could help Cas9 cut a previously inaccessible PAM.

[0081] Figures 9A to 9B show dCas9-VPR binding activity on the NNNNN PAM

Library. Figure 9A is a graph representing dCas9-VPR binding activity on the NNNNN PAM library as a function of the % cells above background fluorescence. Figure 9B is a graph representing dCas9-VPR binding activity on the NNNNN PAM library as a function of mean fluorescence.

[0082] Figure 10 shows Cas9 cutting activity using % of cells with GFP loss as a readout. Cas9 proteins were tested with two sgRNAs, which either targeted the canonical 5'- NGG-3 ' PAM or a GAT PAM within a GFP gene.

[0083] Figure 11 illustrates double-stranded DNA substrate bound by Cas9:DNA editing enzyme: sgRNA complexes. The DNA editing enzyme may be, without limitation, a nuclease, nickase, recombinase, deaminase, methyltransferase, methylase, acetylase, or acetyltransferase.

[0084] Figures 12A to 12D show the results of the PAM depletion assay. pJH760 was tested in the PAM depletion assay on four new targets: re2 (Figure 12 A), VEGF (Figure 12B), CLTA (Figure 12C), and CCR5D (Figure 12D).

[0085] Figure 13 shows GFP cutting in mammalian cells.

[0086] Figure 14 shows the results of a PAM depletion assay to test pJH760 (xCas9 v 1.0) on the re2 target.

[0087] Figure 15 shows the results of a PAM depletion assay to test pJH760 (xCas9 vl .0) on the VEGF target.

[0088] Figure 16 shows the results of a PAM depletion assay to test pJH760 (xCas9 vl .0) on the CLTA target.

[0089] Figure 17 shows the results of a PAM depletion assay to test pJH760 (xCas9 vl .0) on the CCR5D target.

[0090] Figure 18 shows the results of a PAM depletion assay to test four xCas9v3 mutants on the re2 target.

[0091] Figure 19 shows the results of a PAM depletion assay to test four xCas9v3 mutants on the VEGF target.

[0092] Figure 20 shows the results of a PAM depletion assay to test four xCas9v3 mutants on the CLTA target. DEFINITIONS

[0093] As used herein and in the claims, the singular forms "a," "an," and "the" include the singular and the plural reference unless the context clearly indicates otherwise. Thus, for example, a reference to "an agent" includes a single agent and a plurality of such agents.

[0094] The term "Cas9" or "Cas9 nuclease" refers to an RNA-guided nuclease comprising a Cas9 protein, or a fragment thereof (e.g., a protein comprising an active or inactive DNA cleavage domain of Cas9, and/or the gRNA binding domain of Cas9). A Cas9 nuclease is also referred to sometimes as a casnl nuclease or a CRISPR (clustered regularly interspaced short palindromic repeat)-associated nuclease. CRISPR is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences

complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and a Cas9 protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently, Cas9/crRNA/tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer. The target strand not complementary to crRNA is first cut endonucleolytically, then trimmed 3 '-5' exonucleolytically. In nature, DNA-binding and cleavage typically requires protein and both RNAs. However, single guide RNAs ("sgRNA", or simply "gNRA") can be engineered so as to incorporate aspects of both the crRNA and tracrRNA into a single RNA species. See, e.g., Jinek M., Chylinski K., Fonfara I, Hauer M., Doudna J. A., Charpentier E. Science 337:816-821(2012), the entire contents of which are hereby incorporated by reference. Cas9 recognizes a short motif in the CRISPR repeat sequences (the PAM or protospacer adjacent motif) to help distinguish self versus non-self. Cas9 nuclease sequences and structures are well known to those of skill in the art (see, e.g., "Complete genome sequence of an Ml strain of Streptococcus pyogenes." Ferretti et al, J. J., McShan W.M., Ajdic D.J., Savic D.J., Savic G., Lyon K., Primeaux C, Sezate S., Suvorov A.N., Kenton S., Lai H.S., Lin S.P., Qian Y., Jia H.G., Najar F.Z., Ren Q., Zhu H., Song L., White J., Yuan X., Clifton S.W., Roe B.A., McLaughlin R.E., Proc. Natl. Acad. Sci. U.S.A. 98:4658-4663(2001); "CRISPR RNA maturation by trans-encoded small RNA and host factor RNase III." Deltcheva E., Chylinski K., Sharma CM., Gonzales K., Chao Y., Pirzada Z.A., Eckert M.R., Vogel J., Charpentier E., Nature 471 :602-607(201 1); and "A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity." Jinek M., Chylinski K., Fonfara I, Hauer M., Doudna J. A., Charpentier E. Science 337:816-821(2012), the entire contents of each of which are incorporated herein by reference). Cas9 orthologs have been described in various species, including, but not limited to, S. pyogenes and S. thermophilus . Additional suitable Cas9 nucleases and sequences will be apparent to those of skill in the art based on this disclosure, and such Cas9 nucleases and sequences include Cas9 sequences from the organisms and loci disclosed in Chylinski, Rhun, and Charpentier, "The tracrRNA and Cas9 families of type II CRISPR-Cas immunity systems" (2013) RNA Biology 10:5, 726-737; the entire contents of which are incorporated herein by reference. In some embodiments, a Cas9 nuclease has an inactive {e.g., an inactivated) DNA cleavage domain.

[0095] A nuclease-inactivated Cas9 protein may interchangeably be referred to as a

"dCas9" protein (for nuclease-"dead" Cas9). Methods for generating a Cas9 having an inactive DNA cleavage domain are known (See, e.g., Jinek et al, Science. 337:816- 821(2012); Qi et al, "Repurposing CRISPR as an RNA-Guided Platform for Sequence- Specific Control of Gene Expression" (2013) Cell. 28; 152(5): 1173-83, the entire contents of each of which are incorporated herein by reference). For example, the DNA cleavage domain of Cas9 is known to include two subdomains, the UNH nuclease subdomain and the RuvCl subdomain. The UNH subdomain cleaves the strand complementary to the gRNA, whereas the RuvCl subdomain cleaves the non-complementary strand. Mutations within these subdomains can silence the nuclease activity of Cas9. For example, the mutations DIOA and H840A completely inactivate the nuclease activity of S. pyogenes Cas9 (Jinek et al, Science. 337:816-821(2012); Qi et al, Cell. 28; 152(5): 1173-83 (2013).

[0096] In some embodiments, proteins comprising fragments of Cas9 are provided.

For example, in some embodiments, a protein comprises one of two Cas9 domains: (1) the gRNA binding domain of Cas9; or (2) the DNA cleavage domain of Cas9. In some embodiments, proteins comprising Cas9 or fragments thereof are referred to as "Cas9 variants." A Cas9 variant shares homology to Cas9. For example a Cas9 variant is at least about 70% identical, at least about 80% identical, at least about 90% identical, at least about 95%) identical, at least about 96%> identical, at least about 97%> identical, at least about 98%> identical, at least about 99%> identical, at least about 99.5%> identical, or at least about 99.9%> to wild type Cas9. In some embodiments, the Cas9 variant comprises a fragment of Cas9 {e.g., a gRNA binding domain or a DNA-cleavage domain), such that the fragment is at least about 70%) identical, at least about 80%> identical, at least about 90%> identical, at least about 95% identical, at least about 96% identical, at least about 97% identical, at least about 98% identical, at least about 99% identical, at least about 99.5% identical, or at least about 99.9% to the corresponding fragment of wild type Cas9. In some embodiments, wild type Cas9 corresponds to Cas9 from Streptococcus pyogenes (NCBI Reference Sequence:

NC 017053.1, SEQ ID NO: l (nucleotide); SEQ ID NO:2 (amino acid)).

AT G GAT AAGAAAT AC T C AAT AG G C T T AGAT AT C G G C AC AAAT AG C GT C G GAT G G G C G GT GAT C AC T GAT GAT TAT AAGGTTCCGTCTAAAAAGTTCAAGGTTCTGGGAAATACAGACCGCCACAGTATCAAAAAAAATCTTATAGGGGCT CTTTTATTTGGCAGTGGAGAGACAGCGGAAGCGACTCGTCTCAAACGGACAGCTCGTAGAAGGTATACACGTCGG AAGAAT C GT AT T T GT TAT C T AC AG GAGAT τ T T T T C AAAT GAGAT G G C GAAAGT AGAT GAT AGT T T C T T T CAT C GA C T T GAAGAGT CTTTTTTGGTG GAAGAAGAC AAGAAG CAT GAAC GT CAT C C TAT T T T T G GAAAT AT AGT AGAT GAA GT T G C T TAT CAT GAGAAAT AT C C AAC TAT C TAT CAT C T G C GAAAAAAAT T G G C AGAT T C T AC T GAT AAAG C G GAT TTGCGCTTAATCTATTTGGCCTTAGCGCATATGATTAAGTTTCGTGGTCATTTTTTGATTGAGGGAGATTTAAAT C C T GAT AAT AGT GAT GT G GAC AAAC TAT T TAT C C AGT T G GT AC AAAT C T AC AAT C AAT TAT T T GAAGAAAAC C C T AT T AAC G C AAGT AGAGT AGAT G C T AAAG C GAT TCTTTCTG C AC GAT T GAGT AAAT C AAGAC GAT T AGAAAAT C T C ATTGCTCAGCTCCCCGGTGAGAAGAGAAATGGCTTGTTTGGGAATCTCATTGCTTTGTCATTGGGATTGACCCCT AAT T T T AAAT C AAAT T T T GAT T T G G C AGAAGAT G C T AAAT T AC AG C T T T C AAAAGAT AC T T AC GAT GAT GAT T T A GATAATTTATTGGCGCAAATTGGAGATCAATATGCTGATTTGTTTTTGGCAGCTAAGAATTTATCAGATGCTATT T T AC T T T C AGAT AT C C TAAGAGT AAAT AGT GAAAT AAC T AAG G C T C C C C TAT C AG C T T C AAT GAT T AAG C G C T AC GAT GAAC AT CAT C AAGAC T T GAC T C T T T T AAAAG CTTTAGTTC GAC AAC AAC T T C C AGAAAAGT AT AAAGAAAT C T T T T T T GAT C AAT C AAAAAAC G GAT AT G C AG GT TAT AT T GAT G G G G GAG C T AG C C AAGAAGAAT T T TAT AAAT T T ATCAAACCAATTTTAGAAAAAATGGATGGTACTGAGGAATTATTGGTGAAACTAAATCGTGAAGATTTGCTGCGC AAGCAACGGACCTTTGACAACGGCTCTATTCCCCATCAAATTCACTTGGGTGAGCTGCATGCTATTTTGAGAAGA C AAGAAGAC T T T T AT C CAT T T T T AAAAGAC AAT C GT GAGAAGAT T GAAAAAAT CTTGACTTTTC GAAT T C C T T AT TATGTTGGTCCATTGGCGCGTGGCAATAGTCGTTTTGCATGGATGACTCGGAAGTCTGAAGAAACAATTACCCCA TGGAATTTTGAAGAAGTTGTCGATAAAGGTGCTTCAGCTCAATCATTTATTGAACGCATGACAAACTTTGATAAA AAT C T T C C AAAT GAAAAAGT AC T AC C AAAAC AT AGT T T G C T T TAT GAGT AT TTTACGGTT TAT AAC GAAT T GAC A AAG GT C AAAT AT GT T AC T GAG G GAAT G C GAAAAC C AG CAT T T C T T T C AG GT GAAC AGAAGAAAG C CAT T GT T GAT TTACTCTT C AAAAC AAAT C GAAAAGT AAC C GT T AAG C AAT T AAAAGAAGAT T AT T T C AAAAAAAT AGAAT GT T T T GAT AGT GT T GAAAT T T C AG GAGT T GAAGAT AGAT T T AAT G C T T CAT TAGGCGCCTAC CAT GAT T T G C T AAAAAT T AT T AAAGAT AAAGAT T T T T T G GAT AAT GAAGAAAAT GAAGAT AT C T T AGAG GAT AT T GT T T T AAC AT T GAC C T T A T T T GAAGAT AG G G G GAT GAT T GAG GAAAGAC T T AAAAC AT AT G C T C AC C T C T T T GAT GAT AAG GT GAT GAAAC AG CTTAAACGTCGCCGTTATACTGGTTGGGGACGTTTGTCTCGAAAATTGATTAATGGTATTAGGGATAAGCAATCT GGCAAAACAATATTAGATTTTTTGAAATCAGATGGTTTTGCCAATCGCAATTTTATGCAGCTGATCCATGATGAT AGT T T GAC AT T T AAAGAAGAT AT T C AAAAAG C AC AG GT GT C T G GAC AAG G C CAT AGT T T AC AT GAAC AGAT T G C T AACTTAGCTGGCAGTCCTGCTATTAAAAAAGGTATTTTACAGACTGTAAAAATTGTTGATGAACTGGTCAAAGTA AT G G G G CAT AAG C C AGAAAAT AT C GT TAT T GAAAT G G C AC GT GAAAAT C AGAC AAC T C AAAAG G G C C AGAAAAAT T C G C GAGAG C GT AT GAAAC GAAT C GAAGAAG GT AT C AAAGAAT TAG GAAGT C AGAT T C T T AAAGAG CAT C C T GT T GAAAAT ACT CAATT GCAAAAT GAAAAG C T C TAT C T C TAT TAT C T AC AAAAT G GAAGAGAC AT GTAT GT GGACCAA GAAT T AGAT AT T AAT C GT T T AAGT GAT TAT GAT GT C GAT CACAT T GT T C CACAAAGT T T CAT TAAAGAC GAT T CA ATAGACAATAAGGTACTAACGCGTTCTGATAAAAATCGTGGTAAATCGGATAACGTTCCAAGTGAAGAAGTAGTC AAAAAGAT GAAAAAC TAT T G GAGAC AAC T T C T AAAC G C C AAGT T AAT C AC T C AAC GT AAGT T T GAT AAT T T AAC G AAAGCTGAACGTGGAGGTTTGAGTGAACTTGATAAAGCTGGTTTTATCAAACGCCAATTGGTTGAAACTCGCCAA AT C AC T AAG CAT GT G G C AC AAAT T T T G GAT AGT C G CAT GAAT AC T AAAT AC GAT GAAAAT GAT AAAC T TAT T C GA GAGGTTAAAGTGATTACCTTAAAATCTAAATTAGTTTCTGACTTCCGAAAAGATTTCCAATTCTATAAAGTACGT GAGAT T AAC AAT T AC CAT CAT G C C CAT GAT G C GTAT C T AAAT GCCGTCGTTG GAAC T G C T T T GAT T AAGAAAT AT CCAAAACTTGAATCGGAGTTTGTCTATGGTGATTATAAAGTTTATGATGTTCGTAAAATGATTGCTAAGTCTGAG C AAGAAAT AG G C AAAG C AAC C G C AAAAT AT TTCTTTTACTC T AAT AT CAT GAAC T T C T T C AAAAC AGAAAT T AC A CTTGCAAATGGAGAGATTCGCAAACGCCCTCTAATCGAAACTAATGGGGAAACTGGAGAAATTGTCTGGGATAAA GGGCGAGATTTTGCCACAGTGCGCAAAGTATTGTCCATGCCCCAAGTCAATATTGTCAAGAAAACAGAAGTACAG ACAGGCGGATTCTCCAAGGAGTCAATTTTACCAAAAAGAAATTCGGACAAGCTTATTGCTCGTAAAAAAGACTGG GATCCAAAAAAATATGGTGGTTTTGATAGTCCAACGGTAGCTTATTCAGTCCTAGTGGTTGCTAAGGTGGAAAAA G G GAAAT C GAAGAAGT T AAAAT C C GT T AAAGAGT T AC T AG G GAT C AC AAT TAT G GAAAGAAGT T C C T T T GAAAAA AAT C C GAT T GAC T T T T T AGAAG C T AAAG GAT AT AAG GAAGT T AAAAAAGAC T T AAT CAT T AAAC T AC C T AAAT AT AGTCTTTTTGAGTTAGAAAACGGTCGTAAACGGATGCTGGCTAGTGCCGGAGAATTACAAAAAGGAAATGAGCTG GCTCTGCCAAGCAAATATGTGAATTTTTTATATTTAGCTAGTCATTATGAAAAGTTGAAGGGTAGTCCAGAAGAT AAC GAAC AAAAAC AAT TGTTTGTG GAG C AG CAT AAG CAT TAT T T AGAT GAGAT TAT T GAG C AAAT C AGT GAAT T T T C T AAG C GT GT TAT T T T AG C AGAT G C C AAT T T AGAT AAAGT TCTTAGTG CAT AT AAC AAAC AT AGAGAC AAAC C A ATACGTGAACAAGCAGAAAATATTATTCATTTATTTACGTTGACGAATCTTGGAGCTCCCGCTGCTTTTAAATAT TTTGATACAACAATTGATCGTAAACGATATACGTCTACAAAAGAAGTTTTAGATGCCACTCTTATCCATCAATCC ATCACTGGTCTTTATGAAACACGCATTGATTTGAGTCAGCTAGGAGGTGACTGA (SEQ ID NO : 1 )

MDKKYSIGLDIGTNSVGWAVITDDYKVPSKKFKVLGNTDRHSIKKNLIGALLFGSGETAEATRLKRTARRRYTRR KNRICYLQEIFSNEMAKVDDSFFHRLEESFLVEEDKKHERHPIFGNIVDEVAYHEKYPTIYHLRKKLADSTDKAD LRLIYLALAHMIKFRGHFLIEGDLNPDNSDVDKLFIQLVQIYNQLFEENPINASRVDAKAILSARLSKSRRLENL IAQLPGEKRNGLFGNLIALSLGLTPNFKSNFDLAEDAKLQLSKDTYDDDLDNLLAQIGDQYADLFLAAKNLSDAI LLSDILR SEITKAPLSASMIKRYDEHHQDLTLLKALVRQQLPEKYKEIFFDQSKNGYAGYIDGGASQEEFYKF IKPILEKMDGTEELLVKLNREDLLRKQRTFDNGSIPHQIHLGELHAILRRQEDFYPFLKDNREKIEKILTFRIPY YVGPLARGNSRFAWMTRKSEETITPWNFEEWDKGASAQSFIERMTNFDKNLPNEKVLPKHSLLYEYFTVYNELT KVKYVTEGMRKPAFLSGEQKKAIVDLLFKTNRKVTVKQLKEDYFKKIECFDSVEISGVEDRFNASLGAYHDLLKI IKDKDFLDNEENEDILEDIVLTLTLFEDRGMIEERLKTYAHLFDDKVMKQLKRRRYTGWGRLSRKLINGIRDKQS GKTILDFLKSDGFANRNFMQLIHDDSLTFKEDIQKAQVSGQGHSLHEQIANLAGSPAIKKGILQTVKIVDELVKV MGHKPENIVIEMARENQTTQKGQKNSRERMKRIEEGIKELGSQILKEHPVENTQLQNEKLYLYYLQNGRDMYVDQ ELDINRLSDYDVDHIVPQSFIKDDSIDNKVLTRSDKNRGKSDNVPSEEWKKMKNYWRQLLNAKLITQRKFDNLT KAERGGLSELDKAGFIKRQLVETRQITKHVAQILDSRMNTKYDENDKLIREVKVITLKSKLVSDFRKDFQFYKVR EINNYHHAHDAYLNAWGTALIKKYPKLESEFVYGDYKVYDVRKMIAKSEQEIGKATAKYFFYSNIMNFFKTEIT LANGEIRKRPLIETNGETGEIVWDKGRDFATVRKVLSMPQ IVKKTEVQTGGFSKESILPKRNSDKLIARKKDW DPKKYGGFDSPTVAYSVLWAKVEKGKSKKLKSVKELLGITIMERSSFEKNPIDFLEAKGYKEVKKDLIIKLPKY SLFELENGRKRMLASAGELQKGNELALPSKY FLYLASHYEKLKGSPEDNEQKQLFVEQHKHYLDEIIEQISEF SKRVILADANLDKVLSAYNKHRDKPIREQAENIIHLFTLTNLGAPAAFKYFDTTIDRKRYTSTKEVLDATLIHQS ITGLYETRIDLSQLGGD (SEQ ID NO : 2 )

(single underline: HNH domain; double underline: RuvC domain)

[0097] In some embodiments, wild type Cas9 corresponds to, or comprises SEQ ID

NO:3 (nucleotide) and/or SEQ ID NO: 4 (amino acid):

ATGGATAAAAAGTATTCTATTGGTTTAGACATCGGCACTAATTCCGTTGGATGGGCTGTCATAACCGATGAATAC AAAGTACCTTCAAAGAAATTTAAGGTGTTGGGGAACACAGACCGTCATTCGATTAAAAAGAATCTTATCGGTGCC CTCCTATTCGATAGTGGCGAAACGGCAGAGGCGACTCGCCTGAAACGAACCGCTCGGAGAAGGTATACACGTCGC AAGAACCGAATATGTTACTTACAAGAAATTTTTAGCAATGAGATGGCCAAAGTTGACGATTCTTTCTTTCACCGT TTGGAAGAGTCCTTCCTTGTCGAAGAGGACAAGAAACATGAACGGCACCCCATCTTTGGAAACATAGTAGATGAG GTGGCATATCATGAAAAGTACCCAACGATTTATCACCTCAGAAAAAAGCTAGTTGACTCAACTGATAAAGCGGAC CTGAGGTTAATCTACTTGGCTCTTGCCCATATGATAAAGTTCCGTGGGCACTTTCTCATTGAGGGTGATCTAAAT CCGGACAACTCGGATGTCGACAAACTGTTCATCCAGTTAGTACAAACCTATAATCAGTTGTTTGAAGAGAACCCT ATAAATGCAAGTGGCGTGGATGCGAAGGCTATTCTTAGCGCCCGCCTCTCTAAATCCCGACGGCTAGAAAACCTG ATCGCACAATTACCCGGAGAGAAGAAAAATGGGTTGTTCGGTAACCTTATAGCGCTCTCACTAGGCCTGACACCA AATTTTAAGTCGAACTTCGACTTAGCTGAAGATGCCAAATTGCAGCTTAGTAAGGACACGTACGATGACGATCTC GACAATCTACTGGCACAAATTGGAGATCAGTATGCGGACTTATTTTTGGCTGCCAAAAACCTTAGCGATGCAATC CTCCTATCTGACATACTGAGAGTTAATACTGAGATTACCAAGGCGCCGTTATCCGCTTCAATGATCAAAAGGTAC GATGAACATCACCAAGACTTGACACTTCTCAAGGCCCTAGTCCGTCAGCAACTGCCTGAGAAATATAAGGAAATA TTCTTTGATCAGTCGAAAAACGGGTACGCAGGTTATATTGACGGCGGAGCGAGTCAAGAGGAATTCTACAAGTTT ATCAAACCCATATTAGAGAAGATGGATGGGACGGAAGAGTTGCTTGTAAAACTCAATCGCGAAGATCTACTGCGA AAGCAGCGGACTTTCGACAACGGTAGCATTCCACATCAAATCCACTTAGGCGAATTGCATGCTATACTTAGAAGG CAGGAGGATTTTTATCCGTTCCTCAAAGACAATCGTGAAAAGATTGAGAAAATCCTAACCTTTCGCATACCTTAC TATGTGGGACCCCTGGCCCGAGGGAACTCTCGGTTCGCATGGATGACAAGAAAGTCCGAAGAAACGATTACTCCA TGGAATTTTGAGGAAGTTGTCGATAAAGGTGCGTCAGCTCAATCGTTCATCGAGAGGATGACCAACTTTGACAAG AATTTACCGAACGAAAAAGTATTGCCTAAGCACAGTTTACTTTACGAGTATTTCACAGTGTACAATGAACTCACG AAAGTTAAGTATGTCACTGAGGGCATGCGTAAACCCGCCTTTCTAAGCGGAGAACAGAAGAAAGCAATAGTAGAT CTGTTATTCAAGACCAACCGCAAAGTGACAGTTAAGCAATTGAAAGAGGACTACTTTAAGAAAATTGAATGCTTC GATTCTGTCGAGATCTCCGGGGTAGAAGATCGATTTAATGCGTCACTTGGTACGTATCATGACCTCCTAAAGATA ATTAAAGATAAGGACTTCCTGGATAACGAAGAGAATGAAGATATCTTAGAAGATATAGTGTTGACTCTTACCCTC TTTGAAGATCGGGAAATGATTGAGGAAAGACTAAAAACATACGCTCACCTGTTCGACGATAAGGTTATGAAACAG TTAAAGAGGCGTCGCTATACGGGCTGGGGACGATTGTCGCGGAAACTTATCAACGGGATAAGAGACAAGCAAAGT GGTAAAACTATTCTCGATTTTCTAAAGAGCGACGGCTTCGCCAATAGGAACTTTATGCAGCTGATCCATGATGAC TCTTTAACCTTCAAAGAGGATATACAAAAGGCACAGGTTTCCGGACAAGGGGACTCATTGCACGAACATATTGCG AATCTTGCTGGTTCGCCAGCCATCAAAAAGGGCATACTCCAGACAGTCAAAGTAGTGGATGAGCTAGTTAAGGTC ATGGGACGTCACAAACCGGAAAACATTGTAATCGAGATGGCACGCGAAAATCAAACGACTCAGAAGGGGCAAAAA AACAGTCGAGAGCGGATGAAGAGAATAGAAGAGGGTATTAAAGAACTGGGCAGCCAGATCTTAAAGGAGCATCCT GT G GAAAAT AC C C AAT T G C AGAAC GAGAAAC TTTACCTC TAT T AC C T AC AAAAT G GAAG G GAC AT GT AT GT T GAT C AG GAAC T G GAC AT AAAC C GT T TAT C T GAT T AC GAC GT C GAT C AC AT T GT AC C C C AAT C C T T T T T GAAG GAC GAT T C AAT C GAC AAT AAAGT G C T T AC AC G C T C G GAT AAGAAC C GAG G GAAAAGT GAC AAT GT T C C AAG C GAG GAAGT C GT AAAGAAAAT GAAGAAC TAT T G G C G G C AG C T C C T AAAT G C GAAAC T GAT AAC G C AAAGAAAGT T C GAT AAC T T A ACTAAAGCTGAGAGGGGTGGCTTGTCTGAACTTGACAAGGCCGGATTTATTAAACGTCAGCTCGTGGAAACCCGC C AAAT C AC AAAG CAT GT T G C AC AGAT AC T AGAT T C C C GAAT GAAT AC GAAAT AC GAC GAGAAC GAT AAG C T GAT T CGGGAAGTCAAAGTAATCACTTTAAAGTCAAAATTGGTGTCGGACTTCAGAAAGGATTTTCAATTCTATAAAGTT AG G GAGAT AAAT AAC T AC C AC CAT G C G C AC GAC G C T TAT C T T AAT GCCGTCGTAGG GAC C G C AC T CAT T AAGAAA TACCCGAAGCTAGAAAGTGAGTTTGTGTATGGTGATTACAAAGTTTATGACGTCCGTAAGATGATCGCGAAAAGC GAAC AG GAGAT AG G C AAG G C T AC AG C C AAAT AC T T C T T T TAT T C T AAC AT TAT GAAT T T C T T T AAGAC G GAAAT C AC T C T G G C AAAC G GAGAGAT AC G C AAAC GAC C T T T AAT T GAAAC C AAT G G G GAGAC AG GT GAAAT C GT AT G G GAT AAGGGCCGGGACTTCGCGACGGTGAGAAAAGTTTTGTCCATGCCCCAAGTCAACATAGTAAAGAAAACTGAGGTG CAGACCGGAGGGTTTTCAAAGGAATCGATTCTTCCAAAAAGGAATAGTGATAAGCTCATCGCTCGTAAAAAGGAC TGGGACCCGAAAAAGTACGGTGGCTTCGATAGCCCTACAGTTGCCTATTCTGTCCTAGTAGTGGCAAAAGTTGAG AAGGGAAAATCCAAGAAACTGAAGTCAGTCAAAGAATTATTGGGGATAACGATTATGGAGCGCTCGTCTTTTGAA AAGAAC C C CAT C GAC T T C C T T GAG G C GAAAG GT T AC AAG GAAGT AAAAAAG GAT C T CAT AAT T AAAC T AC C AAAG TATAGTCTGTTTGAGTTAGAAAATGGCCGAAAACGGATGTTGGCTAGCGCCGGAGAGCTTCAAAAGGGGAACGAA CTCGCACTACCGTCTAAATACGTGAATTTCCTGTATTTAGCGTCCCATTACGAGAAGTTGAAAGGTTCACCTGAA GAT AAC GAAC AGAAG C AAC TTTTTGTT GAG C AG C AC AAAC AT TAT C T C GAC GAAAT C AT AGAG C AAAT T T C G GAA T T C AGT AAGAGAGT CAT C C T AG C T GAT G C C AAT C T G GAC AAAGT AT T AAG C G CAT AC AAC AAG C AC AG G GAT AAA CCCATACGTGAGCAGGCGGAAAATATTATCCATTTGTTTACTCTTACCAACCTCGGCGCTCCAGCCGCATTCAAG TAT T T T GAC AC AAC GAT AGAT C G C AAAC GAT AC AC T T C T AC C AAG GAG GT G C T AGAC G C GAC AC T GAT T C AC C AA T C CAT C AC G G GAT TAT AT GAAAC T C G GAT AGAT T T GT C AC AG CTTGGGGGT GAC G GAT C C C C C AAGAAGAAGAG G AAAGT C T C GAG C GAC T AC AAAGAC CAT GAC G GT GAT T AT AAAGAT CAT GAC AT C GAT T AC AAG GAT GAC GAT GAC

AAGGCTGCAGGA (SEQ ID NO: 3)

MDKKYS I GLAI GTNSVGWAVITDEYKVPSKKFKVLGNTDRHS I KKNLI GALLFDSGETAEATRLKRTARRRYTRR KNRI CYLQEI FSNEMAKVDDS FFHRLEES FLVEEDKKHERHPI FGNIVDEVAYHEKYPTIYHLRKKLVDSTDKAD LRLIYLALAHMI KFRGHFLI EGDLNPDNSDVDKLFIQLVQTYNQLFEENPINASGVDAKAI LSARLSKSRRLENL IAQLPGEKKNGLFGNLIALSLGLTPNFKSNFDLAEDAKLQLSKDTYDDDLDNLLAQI GDQYADLFLAAKNLSDAI LLSDI LR TEITKAPLSASMI KRYDEHHQDLTLLKALVRQQLPEKYKEI FFDQSKNGYAGYI DGGASQEEFYKF I KPI LEKMDGTEELLVKLNREDLLRKQRTFDNGS I PHQIHLGELHAI LRRQEDFYPFLKDNREKI EKI LTFRI PY YVGPLARGNSRFAWMTRKSEETITPWNFEEWDKGASAQS FI ERMTNFDKNLPNEKVLPKHSLLYEYFTVYNELT KVKYVTEGMRKPAFLSGEQKKAIVDLLFKTNRKVTVKQLKEDYFKKI ECFDSVEI SGVEDRFNASLGTYHDLLKI I KDKDFLDNEENEDI LEDIVLTLTLFEDREMI EERLKTYAHLFDDKVMKQLKRRRYTGWGRLSRKLINGI RDKQS GKTI LDFLKSDGFANRNFMQLIHDDSLTFKEDIQKAQVSGQGDSLHEHIANLAGS PAI KKGI LQTVKWDELVKV MGRHKPENIVI EMARENQTTQKGQKNSRERMKRI EEGI KELGSQI LKEHPVENTQLQNEKLYLYYLQNGRDMYVD QELDINRLSDYDVDHIVPQS FLKDDS I DNKVLTRSDKNRGKSDNVPSEEWKKMKNYWRQLLNAKLITQRKFDNL TKAERGGLSELDKAGFI KRQLVETRQITKHVAQI LDSRMNTKYDENDKLI REVKVITLKSKLVSDFRKDFQFYKV REINNYHHAHDAYLNAWGTALI KKYPKLESEFVYGDYKVYDVRKMIAKSEQEI GKATAKYFFYSNIMNFFKTEI TLANGEI RKRPLI ETNGETGEIVWDKGRDFATVRKVLSMPQ IVKKTEVQTGGFSKES I LPKRNSDKLIARKKD WDPKKYGGFDS PTVAYSVLWAKVEKGKSKKLKSVKELLGITIMERS S FEKNPI DFLEAKGYKEVKKDLI I KLPK YSLFELENGRKRMLASAGELQKGNELALPSKY FLYLASHYEKLKGS PEDNEQKQLFVEQHKHYLDEI I EQI SE FSKRVI LADANLDKVLSAYNKHRDKPI REQAENI IHLFTLTNLGAPAAFKYFDTTI DRKRYTSTKEVLDATLIHQ

S ITGLYETRI DLSQLGGD (SEQ ID NO:4)

(single underline: HNH domain; double underline: RuvC domain)

[0098] In some embodiments, wild type Cas9 corresponds to Cas9 from

Streptococcus pyogenes (NCBI Reference Sequence: NC_002737.2, SEQ ID NO: 282 (nucleotide); and Uniport Reference Sequence: Q99ZW2, SEQ ID NO: 9 (amino acid).

AT G GAT AAGAAAT AC T C AAT AG G C T T AGAT AT C G G C AC AAAT AG C GT C G GAT G G G C G GT GAT C AC T GAT GAAT AT AAGGTTCCGTCTAAAAAGTTCAAGGTTCTGGGAAATACAGACCGCCACAGTATCAAAAAAAATCTTATAGGGGCT CTTTTATTTGACAGTGGAGAGACAGCGGAAGCGACTCGTCTCAAACGGACAGCTCGTAGAAGGTATACACGTCGG AAGAAT C GT AT T T GT TAT C T AC AG GAGAT τ T T T T C AAAT GAGAT G G C GAAAGT AGAT GAT AGT T T C T T T CAT C GA C T T GAAGAGT CTTTTTTGGTG GAAGAAGAC AAGAAG CAT GAAC GT CAT C C TAT T T T T G GAAAT AT AGT AGAT GAA GT T G C T TAT CAT GAGAAAT AT C C AAC TAT C TAT CAT C T G C GAAAAAAAT T G GT AGAT T C T AC T GAT AAAG C G GAT TTGCGCTTAATCTATTTGGCCTTAGCGCATATGATTAAGTTTCGTGGTCATTTTTTGATTGAGGGAGATTTAAAT C C T GAT AAT AGT GAT GT G GAC AAAC TAT T TAT C C AGT T G GT AC AAAC C T AC AAT C AAT TAT T T GAAGAAAAC C C T AT T AAC G C AAGT G GAGT AGAT G C T AAAG C GAT TCTTTCTG C AC GAT T GAGT AAAT C AAGAC GAT T AGAAAAT C T C ATTGCTCAGCTCCCCGGTGAGAAGAAAAATGGCTTATTTGGGAATCTCATTGCTTTGTCATTGGGTTTGACCCCT AAT T T T AAAT C AAAT T T T GAT T T G G C AGAAGAT G C T AAAT T AC AG C T T T C AAAAGAT AC T T AC GAT GAT GAT T T A GATAATTTATTGGCGCAAATTGGAGATCAATATGCTGATTTGTTTTTGGCAGCTAAGAATTTATCAGATGCTATT T T AC T T T C AGAT AT C C T AAGAGT AAAT AC T GAAAT AAC T AAG G C T C C C C TAT C AG C T T C AAT GAT T AAAC G C T AC GAT GAAC AT CAT C AAGAC T T GAC T C T T T T AAAAG CTTTAGTTC GAC AAC AAC T T C C AGAAAAGT AT AAAGAAAT C T T T T T T GAT C AAT C AAAAAAC G GAT AT G C AG GT TAT AT T GAT G G G G GAG C T AG C C AAGAAGAAT T T TAT AAAT T T ATCAAACCAATTTTAGAAAAAATGGATGGTACTGAGGAATTATTGGTGAAACTAAATCGTGAAGATTTGCTGCGC AAGCAACGGACCTTTGACAACGGCTCTATTCCCCATCAAATTCACTTGGGTGAGCTGCATGCTATTTTGAGAAGA C AAGAAGAC T T T T AT C CAT T T T T AAAAGAC AAT C GT GAGAAGAT T GAAAAAAT CTTGACTTTTC GAAT T C C T T AT TATGTTGGTCCATTGGCGCGTGGCAATAGTCGTTTTGCATGGATGACTCGGAAGTCTGAAGAAACAATTACCCCA TGGAATTTTGAAGAAGTTGTCGATAAAGGTGCTTCAGCTCAATCATTTATTGAACGCATGACAAACTTTGATAAA AAT C T T C C AAAT GAAAAAGT AC T AC C AAAAC AT AGT T T G C T T TAT GAGT AT TTTACGGTT TAT AAC GAAT T GAC A AAG GT C AAAT AT GT T AC T GAAG GAAT G C GAAAAC C AG CAT T T C T T T C AG GT GAAC AGAAGAAAG C CAT T GT T GAT TTACTCTT C AAAAC AAAT C GAAAAGT AAC C GT T AAG C AAT T AAAAGAAGAT T AT T T C AAAAAAAT AGAAT GT T T T GAT AGT GT T GAAAT T T C AG GAGT T GAAGAT AGAT T T AAT G C T T CAT TAGGTACCTAC CAT GAT T T G C T AAAAAT T AT T AAAGAT AAAGAT T T T T T G GAT AAT GAAGAAAAT GAAGAT AT C T T AGAG GAT AT T GT T T T AAC AT T GAC C T T A T T T GAAGAT AG G GAGAT GAT T GAG GAAAGAC T T AAAAC AT AT G C T C AC C T C T T T GAT GAT AAG GT GAT GAAAC AG CTTAAACGTCGCCGTTATACTGGTTGGGGACGTTTGTCTCGAAAATTGATTAATGGTATTAGGGATAAGCAATCT GGCAAAACAATATTAGATTTTTTGAAATCAGATGGTTTTGCCAATCGCAATTTTATGCAGCTGATCCATGATGAT AGT T T GAC AT T T AAAGAAGAC AT T C AAAAAG C AC AAGT GT C T G GAC AAG G C GAT AGT T T AC AT GAAC AT AT T G C A AATTTAGCTGGTAGCCCTGCTATTAAAAAAGGTATTTTACAGACTGTAAAAGTTGTTGATGAATTGGTCAAAGTA AT G G G G C G G CAT AAG C C AGAAAAT AT C GT TAT T GAAAT G G C AC GT GAAAAT C AGAC AAC T C AAAAG G G C C AGAAA AAT T C G C GAGAG C GT AT GAAAC GAAT C GAAGAAG GT AT C AAAGAAT TAG GAAGT C AGAT T C T T AAAGAG CAT C C T GTT GAAAAT ACT CAATT GCAAAAT GAAAAG C T C TAT C T C TAT TAT C T C C AAAAT G GAAGAGAC AT GTAT GT GGAC CAAGAAT T AGAT AT T AAT C GT T T AAGT GAT TAT GAT GT C GAT CACAT T GT T C CACAAAGT T T CCTTAAAGAC GAT TCAATAGACAATAAGGTCTTAACGCGTTCTGATAAAAATCGTGGTAAATCGGATAACGTTCCAAGTGAAGAAGTA GT C AAAAAGAT GAAAAAC TAT T G GAGAC AAC T T C T AAAC G C C AAGT T AAT C AC T C AAC GT AAGT T T GAT AAT T T A ACGAAAGCTGAACGTGGAGGTTTGAGTGAACTTGATAAAGCTGGTTTTATCAAACGCCAATTGGTTGAAACTCGC C AAAT C AC T AAG CAT GT G G C AC AAAT T T T G GAT AGT C G CAT GAAT AC T AAAT AC GAT GAAAAT GAT AAAC T TAT T C GAGAG GT T AAAGT GAT T AC C T T AAAAT C T AAAT TAGTTTCT GAC T T C C GAAAAGAT T T C C AAT T C T AT AAAGT A CGTGAGATTAACAATTACCATCATGCCCATGATGCGTATCTAAATGCCGTCGTTGGAACTGCTTTGATTAAGAAA TATCCAAAACTTGAATCGGAGTTTGTCTATGGTGATTATAAAGTTTATGATGTTCGTAAAATGATTGCTAAGTCT GAG C AAGAAAT AG G C AAAG C AAC C G C AAAAT AT TTCTTTTACTC T AAT AT CAT GAAC T T C T T C AAAAC AGAAAT T ACACTTGCAAATGGAGAGATTCGCAAACGCCCTCTAATCGAAACTAATGGGGAAACTGGAGAAATTGTCTGGGAT AAAGGGCGAGATTTTGCCACAGTGCGCAAAGTATTGTCCATGCCCCAAGTCAATATTGTCAAGAAAACAGAAGTA C AGAC AG G C G GAT T C T C C AAG GAGT C AAT T T T AC C AAAAAGAAAT T C G GAC AAG C T TAT T G C T C GT AAAAAAGAC TGGGATCCAAAAAAATATGGTGGTTTTGATAGTCCAACGGTAGCTTATTCAGTCCTAGTGGTTGCTAAGGTGGAA AAAG G GAAAT C GAAGAAGT T AAAAT C C GT T AAAGAGT T AC T AG G GAT C AC AAT TAT G GAAAGAAGT T C C T T T GAA AAAAAT C C GAT T GAC T T T T T AGAAG C T AAAG GAT AT AAG GAAGT T AAAAAAGAC T T AAT CAT T AAAC T AC C T AAA TATAGTCTTTTTGAGTTAGAAAACGGTCGTAAACGGATGCTGGCTAGTGCCGGAGAATTACAAAAAGGAAATGAG CTGGCTCTGCCAAGCAAATATGTGAATTTTTTATATTTAGCTAGTCATTATGAAAAGTTGAAGGGTAGTCCAGAA GAT AAC GAAC AAAAAC AAT TGTTTGTG GAG C AG CAT AAG CAT TAT T T AGAT GAGAT TAT T GAG C AAAT C AGT GAA T T T T C T AAG C GT GT TAT T T T AG C AGAT G C C AAT T T AGAT AAAGT TCTTAGTG C AT AT AAC AAAC AT AGAGAC AAA CCAATACGTGAACAAGCAGAAAATATTATTCATTTATTTACGTTGACGAATCTTGGAGCTCCCGCTGCTTTTAAA T AT T T T GAT AC AAC AAT T GAT C GT AAAC GAT AT AC GT C T AC AAAAGAAGT T T T AGAT GCCACTCTTATC CAT C AA TCCATCACTGGTCTTTATGAAACACGCATTGATTTGAGTCAGCTAGGAGGTGACTGA (SEQ ID NO: 282)

MDKKYS I GLDI GTNSVGWAVITDEYKVPSKKFKVLGNTDRHS I KKNLI GALLFDSGETAEATRLKRTARRRYTRR KNRI CYLQEI FSNEMAKVDDS FFHRLEES FLVEEDKKHERHPI FGNIVDEVAYHEKYPTIYHLRKKLVDSTDKAD LRLIYLALAHMI KFRGHFLI EGDLNPDNSDVDKLFIQLVQTYNQLFEENPINASGVDAKAI LSARLSKSRRLENL IAQLPGEKKNGLFGNLIALSLGLTPNFKSNFDLAEDAKLQLSKDTYDDDLDNLLAQI GDQYADLFLAAKNLSDAI LLSDI LR TEITKAPLSASMI KRYDEHHQDLTLLKALVRQQLPEKYKEI FFDQSKNGYAGYI DGGASQEEFYKF I KPI LEKMDGTEELLVKLNREDLLRKQRTFDNGS I PHQIHLGELHAI LRRQEDFYPFLKDNREKI EKI LTFRI PY YVGPLARGNSRFAWMTRKSEETITPWNFEEWDKGASAQS FI ERMTNFDKNLPNEKVLPKHSLLYEYFTVYNELT KVKYVTEGMRKPAFLSGEQKKAIVDLLFKTNRKVTVKQLKEDYFKKI ECFDSVEI SGVEDRFNASLGTYHDLLKI I KDKDFLDNEENEDI LEDIVLTLTLFEDREMI EERLKTYAHLFDDKVMKQLKRRRYTGWGRLSRKLINGI RDKQS GKTI LDFLKSDGFANRNFMQLIHDDSLTFKEDIQKAQVSGQGDSLHEHIANLAGS PAI KKGI LQTVKWDELVKV MGRHKPENIVIEMARENQTTQKGQKNSRERMKRIEEGIKELGSQILKEHPVENTQLQNEKLYLYYLQNGRDMYVD QELDINRLSDYDVDHIVPQSFLKDDSIDNKVLTRSDKNRGKSDNVPSEEWKKMKNYWRQLLNAKLITQRKFDNL TKAERGGLSELDKAGFIKRQLVETRQITKHVAQILDSRMNTKYDENDKLIREVKVITLKSKLVSDFRKDFQFYKV REINNYHHAHDAYLNAWGTALIKKYPKLESEFVYGDYKVYDVRKMIAKSEQEIGKATAKYFFYSNIMNFFKTEI TLANGEIRKRPLIETNGETGEIVWDKGRDFATVRKVLSMPQ IVKKTEVQTGGFSKESILPKRNSDKLIARKKD WDPKKYGGFDSPTVAYSVLWAKVEKGKSKKLKSVKELLGITIMERSSFEKNPIDFLEAKGYKEVKKDLIIKLPK YSLFELENGRKRMLASAGELQKGNELALPSKY FLYLASHYEKLKGSPEDNEQKQLFVEQHKHYLDEIIEQISE FSKRVILADANLDKVLSAYNKHRDKPIREQAENIIHLFTLTNLGAPAAFKYFDTTIDRKRYTSTKEVLDATLIHQ

siTGLYETRiDLSQLGGD (SEQ ID NO: 9) (single underline: HNH domain; double underline: RuvC domain)

[0099] In some embodiments, Cas9 refers to Cas9 from: Coryne bacterium ulcer ans

(NCBI Refs: NC_015683.1, NC_017317.1); Coryne bacterium diphtheria (NCBI Refs:

NC_016782.1, NC_016786.1); Spiroplasma syrphidicola (NCBI Ref: NC_021284.1);

Prevotella intermedia (NCBI Ref: NC 017861.1); Spiroplasma taiwanense (NCBI Ref:

NC_021846.1); Streptococcus iniae (NCBI Ref: NC_021314.1); Belliella baltica (NCBI Ref: NC_018010.1); Psychroflexus torquisl (NCBI Ref: NC_018721.1); Streptococcus

thermophilus (NCBI Ref: YP_820832.1); Listeria innocua (NCBI Ref: NP_472073.1);

Campylobacter jejuni (NCBI Ref: YP_002344900.1); or Neisseria, meningitidis (NCBI Ref: YP 002342100.1) or to a Cas9 from any of the organisms listed in Example 3.

[00100] In some embodiments, dCas9 corresponds to, or comprises in part or in whole, a Cas9 amino acid sequence having one or more mutations that inactivate the Cas9 nuclease activity. For example, in some embodiments, a dCas9 domain comprises D10A and/or H840A mutation. dCas9 (D10A and H840A):

MDKKYSIGLA*IGTNSVG AVITDEYKVPSKKFKVLGNTDRHSIKKNLIGALLFDSGETAEATRLKRTARRRYTR

RKNRICYLQEIFSNEMAKVDDSFFHRLEESFLVEEDKKHERHPIFGNI*VDEVAYHEKYPTIYH*LRKKLVDSTD KADLRLIYLALAHMIKFRGHFLIEGDLNPDNSDVD*KLFIQLVQTYNQLFEENPINASGVDAKAILSARLSKSRR LENLIAQLPGEKKNGLFGNLIALSLGLTPNFKSNFDLAEDA*KLQLSKDTYDDDLDNLLAQIGDQYADLFLAAK* NLSDAILLSDILR TEITKAPLSASMIKRYDEHHQDLTLLKALVRQQLPEKYKEIFFDQSKNGYAGYIDGGASQ EEFYKFIKPILEKMDGTEELLVKLNREDLLRKQRTFDNGS*IPHQIHLGELHAILRRQEDFYPFLKDNREKIEKI LTFRIPYYVGPLARGNSRFAWMTRKSEETITPWNFEE*WDKGASAQSFIERMTNFDKNLPNEKVLPKHSLLYEY FTVYNELTKVKYVTEGMRKPAFLSGE*QKKAIVDLLFKTNRKVTVKQLKEDYFKKIECFDSVEISGVEDRFNASL GTYHDLLKIIKDKDFLDNEENEDILEDIVLTLTLFEDREMIEERLKTYAHLFDDKVMKQLKRRRYTGWG*RLSRK LINGIRDKQSGKTILDFLKSDGFANRNFMQLIHDDSLTFKEDIQKAQVSGQG|DSLHEHIANLAGSPAIKKGILQT| IVKWDELVKVMGRHKPENIVIEMALRENQTTQKGQKNSRA

LQNGRDMYVDQELDI_ LSDYDVDAIVPQSFLKDDSID_raV^

LITQRKFDNLTKAERG|GLSELDKAGFIKRQLVETRQITKHVAQILDSRMNTKYDENDKLIREVKVITLKSKLVSD| |FRKDFQFYKVREINNYHHAHDAYLNAWGTALIKKYPKLESEFVYGDYKVYDVRKMIAKSEQEIGKATAKYFFYS| |NIMNFFKTEITLANGEIRKRPLIETNGETGEI DKGRDFATVRKVLSMPQ IVKKTEVQT|GGFSKESILPKRN SDKLIARKKDWDPKKYGGFDSPTVAYSVLWAKVEKGKSKKLKSVKELLGITIMERSSFEKNPIDFLEAKGYKEV KKDLIIKLPKYSLFELENGRKRMLASAGELQKGNELALPSKY FLYLASHYEKLKGSPEDNEQKQLFVEQHKHY LDEIIEQISEFSKRVILADANLDKVLSAYNKHRDKPIREQAENIIHLFTLTNLGAPAAFKYFDTTIDRKRYTSTK EVLDATLIHQSITGLYETRIDLSQLGGD

(SEQ ID NO: 8) (single underline: HNH domain; double underline: RuvC domain)

[00101] In some embodiments, Cas9 corresponds to, or comprises in part or in whole, a Cas9 amino acid sequence having one or more mutations that alter Cas9's nuclease activity. In some embodiments, Cas9 may be a Cas9 nickase, which is a version of Cas9 that generates a single-stranded DNA break at a specific location based on a co-expressed gRNA-defined target sequence, rather than a double-strand DNA break. For example, in some embodiments, a Cas9 domain comprises D10A mutation (e.g., SEQ ID NO: 301) and/or an H840A mutation (e.g., SEQ ID NO: 302). Exemplary Cas9 nickases are shown below. However, it should be appreciated that additional Cas9 nickases that generate a single-stranded DNA break of a DNA duplex would be apparent to the skilled artisan and are within the scope of this disclosure.

Cas9 D10A nickase:

MDKKYSIGLAIGTNSVGWAVITDEYKVPSKKFKVLGNTDRHSIKKNLIGALLFDSGETAEATRLKRTARRRYTRR KNRICYLQEIFSNEMAKVDDSFFHRLEESFLVEEDKKHERHPIFGNIVDEVAYHEKYPTIYHLRKKLVDSTDKAD LRLIYLALAHMIKFRGHFLIEGDLNPDNSDVDKLFIQLVQTYNQLFEENPINASGVDAKAILSARLSKSRRLENL IAQLPGEKKNGLFGNLIALSLGLTPNFKSNFDLAEDAKLQLSKDTYDDDLDNLLAQIGDQYADLFLAAKNLSDAI LLSDILR TEITKAPLSASMIKRYDEHHQDLTLLKALVRQQLPEKYKEIFFDQSKNGYAGYIDGGASQEEFYKF IKPILEKMDGTEELLVKLNREDLLRKQRTFDNGSIPHQIHLGELHAILRRQEDFYPFLKDNREKIEKILTFRIPY YVGPLARGNSRFAWMTRKSEETITPWNFEEWDKGASAQSFIERMTNFDKNLPNEKVLPKHSLLYEYFTVYNELT KVKYVTEGMRKPAFLSGEQKKAIVDLLFKTNRKVTVKQLKEDYFKKIECFDSVEISGVEDRFNASLGTYHDLLKI IKDKDFLDNEENEDILEDIVLTLTLFEDREMIEERLKTYAHLFDDKVMKQLKRRRYTGWGRLSRKLINGIRDKQS GKTILDFLKSDGFANRNFMQLIHDDSLTFKEDIQKAQVSGQGDSLHEHIANLAGSPAIKKGILQTVKWDELVKV MGRHKPENIVIEMARENQTTQKGQKNSRERMKRIEEGIKELGSQILKEHPVENTQLQNEKLYLYYLQNGRDMYVD QELDINRLSDYDVDHIVPQSFLKDDSIDNKVLTRSDKNRGKSDNVPSEEWKKMKNYWRQLLNAKLITQRKFDNL TKAERGGLSELDKAGFIKRQLVETRQITKHVAQILDSRMNTKYDENDKLIREVKVITLKSKLVSDFRKDFQFYKV REINNYHHAHDAYLNAWGTALIKKYPKLESEFVYGDYKVYDVRKMIAKSEQEIGKATAKYFFYSNIMNFFKTEI TLANGEIRKRPLIETNGETGEI DKGRDFATVRKVLSMPQ IVKKTEVQTGGFSKESILPKRNSDKLIARKKD WDPKKYGGFDSPTVAYSVLWAKVEKGKSKKLKSVKELLGITIMERSSFEKNPIDFLEAKGYKEVKKDLIIKLPK YSLFELENGRKRMLASAGELQKGNELALPSKY FLYLASHYEKLKGSPEDNEQKQLFVEQHKHYLDEIIEQISE FSKRVILADANLDKVLSAYNKHRDKPIREQAENIIHLFTLTNLGAPAAFKYFDTTIDRKRYTSTKEVLDATLIHQ

siTGLYETRiDLSQLGGD (SEQ ID NO: 301) (single underline: HNH domain; double underline: RuvC domain)

Cas9 H840A nickase:

MDKKYSIGLDIGTNSVGWAVITDEYKVPSKKFKVLGNTDRHSIKKNLIGALLFDSGETAEATRLKRTARRRYTRR KNRICYLQEIFSNEMAKVDDSFFHRLEESFLVEEDKKHERHPIFGNIVDEVAYHEKYPTIYHLRKKLVDSTDKAD LRLIYLALAHMIKFRGHFLIEGDLNPDNSDVDKLFIQLVQTYNQLFEENPINASGVDAKAILSARLSKSRRLENL IAQLPGEKKNGLFGNLIALSLGLTPNFKSNFDLAEDAKLQLSKDTYDDDLDNLLAQIGDQYADLFLAAKNLSDAI LLSDILR TEITKAPLSASMIKRYDEHHQDLTLLKALVRQQLPEKYKEIFFDQSKNGYAGYIDGGASQEEFYKF IKPILEKMDGTEELLVKLNREDLLRKQRTFDNGSIPHQIHLGELHAILRRQEDFYPFLKDNREKIEKILTFRIPY YVGPLARGNSRFAWMTRKSEETITPWNFEEWDKGASAQSFIERMTNFDKNLPNEKVLPKHSLLYEYFTVYNELT KVKYVTEGMRKPAFLSGEQKKAIVDLLFKTNRKVTVKQLKEDYFKKIECFDSVEISGVEDRFNASLGTYHDLLKI IKDKDFLDNEENEDILEDIVLTLTLFEDREMIEERLKTYAHLFDDKVMKQLKRRRYTGWGRLSRKLINGIRDKQS GKTILDFLKSDGFANRNFMQLIHDDSLTFKEDIQKAQVSGQGDSLHEHIANLAGSPAIKKGILQTVKWDELVKV MGRHKPENIVIEMARENQTTQKGQKNSRERMKRIEEGIKELGSQILKEHPVENTQLQNEKLYLYYLQNGRDMYVD QELDINRLSDYDVDAIVPQSFLKDDSIDNKVLTRSDKNRGKSDNVPSEEWKKMKNYWRQLLNAKLITQRKFDNL TKAERGGLSELDKAGFIKRQLVETRQITKHVAQILDSRMNTKYDENDKLIREVKVITLKSKLVSDFRKDFQFYKV REINNYHHAHDAYLNAWGTALIKKYPKLESEFVYGDYKVYDVRKMIAKSEQEIGKATAKYFFYSNIMNFFKTEI TLANGEIRKRPLIETNGETGEIVWDKGRDFATVRKVLSMPQ IVKKTEVQTGGFSKESILPKRNSDKLIARKKD WDPKKYGGFDSPTVAYSVLWAKVEKGKSKKLKSVKELLGITIMERSSFEKNPIDFLEAKGYKEVKKDLIIKLPK YSLFELENGRKRMLASAGELQKGNELALPSKY FLYLASHYEKLKGSPEDNEQKQLFVEQHKHYLDEIIEQISE FSKRVILADANLDKVLSAYNKHRDKPIREQAENIIHLFTLTNLGAPAAFKYFDTTIDRKRYTSTKEVLDATLIHQ

siTGLYETRiDLSQLGGD (SEQ ID NO: 302) (single underline: HNH domain; double underline: RuvC domain)

[00102] In other embodiments, dCas9 variants having mutations other than D10A and

H840A are provided, which, e.g., result in nuclease-inactivated Cas9 (dCas9). Such mutations, by way of example, include other amino acid substitutions at D10 and H820, or other substitutions within the nuclease domains of Cas9 (e.g., substitutions in the HNH nuclease subdomain and/or the RuvCl subdomain). In some embodiments, variants or homologues of dCas9 (e.g., variants of SEQ ID NO: 9) are provided which are at least about 70% identical, at least about 80% identical, at least about 90% identical, at least about 95% identical, at least about 98% identical, at least about 99% identical, at least about 99.5% identical, or at least about 99.9% identical to SEQ ID NO: 9. In some embodiments, variants of dCas9 (e.g., variants of SEQ ID NO: 9) are provided having amino acid sequences which are shorter, or longer than SEQ ID NO: 9, by about 5 amino acids, by about 10 amino acids, by about 15 amino acids, by about 20 amino acids, by about 25 amino acids, by about 30 amino acids, by about 40 amino acids, by about 50 amino acids, by about 75 amino acids, by about 100 amino acids, or more.

[00103] In some embodiments, Cas9 fusion proteins as provided herein comprise the full-length amino acid sequence of a Cas9 protein, e.g., one of the sequences provided above. In other embodiments, however, fusion proteins as provided herein do not comprise a full- length Cas9 sequence, but only a fragment thereof. For example, in some embodiments, a Cas9 fusion protein provided herein comprises a Cas9 fragment, wherein the fragment binds crRNA and tracrRNA or a sgRNA, but does not comprise a functional nuclease domain, e.g., it comprises only a truncated version of a nuclease domain or no nuclease domain at all. Exemplary amino acid sequences of suitable Cas9 domains and Cas9 fragments are provided herein, and additional suitable sequences of Cas9 domains and Cas9 fragments will be apparent to those of skill in the art. In some embodiments, a Cas9 fragment is at least 30%, at least 35%, at least 40%, at least 45%, at least 50%, at least 55%, at least 60%, at least 65%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 95% identical, at least 96%, at least 97%, at least 98%, at least 99%, or at least 99.5% of the amino acid length of a corresponding wild type Cas9 protein. In some embodiments, a Cas9 fragment comprises at least at least 100 amino acids in length. In some embodiments, the Cas9 fragment is at least 100, 150, 200, 250, 300, 350, 400, 450, 500, 550, 600, 650, 700, 750, 800, 850, 900, 950, 1000, 1050, 1100, 1150, 1200, 1250, 1300, 1350, 1400, 1450, 1500, 1550, or at least 1600 amino acids of a corresponding wild type Cas9 protein. In some embodiments, the Cas9 fragment comprises an amino acid sequence that has at least 10, at least 15, at least 20, at least 30, at leat 40, at least 50, at least 60, at least 70, at least 80, at least 90, at least 100, at least 150, at least 200, at least 250, at least 300, at least 350, at least 400, at least 500, at least 600, at least 700, at least 800, at least 900, at least 1000, at least 1100, or at least 1200 identical contiguous amino acid residues of a corresponding wild type Cas9 protein.

[00104] Cas9.In some embodiments, Cas9 refers to Cas9 from: Corynebacterium ulcerans (NCBI Refs: NC_015683.1, NC_017317.1); Corynebacterium diphtheria (NCBI Refs: NC_016782.1, NC_016786.1); Spiroplasma syrphidicola (NCBI Ref: NC_021284.1); Prevotella intermedia (NCBI Ref: NC 017861.1); Spiroplasma taiwanense (NCBI Ref: NC_021846.1); Streptococcus iniae (NCBI Ref: NC_021314.1); Belliella baltica (NCBI Ref: NC_018010.1); Psychroflexus torquisl (NCBI Ref: NC_018721.1); Streptococcus

thermophilus (NCBI Ref: YP_820832.1); Listeria innocua (NCBI Ref: NP_472073.1);

Campylobacter jejuni (NCBI Ref: YP_002344900.1); or Neisseria, meningitidis (NCBI Ref: YP_002342100.1).

[00105] The term "deaminase" or "deaminase domain," as used herein, refers to a protein or enzyme that catalyzes a deamination reaction. In some embodiments, the deaminase or deaminase domain is a cytidine deaminase, catalyzing the hydrolytic deamination of cytidine or deoxycytidine to uridine or deoxyuridine, respectively. In some embodiments, the deaminase or deaminase domain is a cytosine deaminase, catalyzing the hydrolytic deamination of cytosine to uracil. In some embodiments, the deaminase or deaminase domain is a naturally-occuring deaminase from an organism, such as a human, chimpanzee, gorilla, monkey, cow, dog, rat, or mouse. In some embodiments, the deaminase or deaminase domain is a variant of a naturally-occuring deaminase from an organism, that does not occur in nature. For example, in some embodiments, the deaminase or deaminase domain is at least 50%, at least 55%, at least 60%, at least 65%, at least 70%, at least 75% at least 80%, at least 85%, at least 90%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%), or at least 99.5% identical to a naturally-occuring deaminase from an organism.

[00106] The term "effective amount," as used herein, refers to an amount of a biologically active agent that is sufficient to elicit a desired biological response. For example, in some embodiments, an effective amount of a nuclease may refer to the amount of the nuclease that is sufficient to induce cleavage of a target site specifically bound and cleaved by the nuclease. In some embodiments, an effective amount of a fusion protein provided herein, e.g., of a fusion protein comprising a nuclease-inactive Cas9 domain and a effector domain (e.g., a deaminase domain) may refer to the amount of the fusion protein that is sufficient to induce editing of a target site specifically bound and edited by the fusion protein. As will be appreciated by the skilled artisan, the effective amount of an agent, e.g., a fusion protein, a nuclease, a deaminase, a recombinase, a hybrid protein, a protein dimer, a complex of a protein (or protein dimer) and a polynucleotide, or a polynucleotide, may vary depending on various factors such as, for example, on the desired biological response, e.g., on the specific allele, genome, or target site to be edited; on the cell or tissue being targeted; and on the agent being used.

[00107] The term "immediately adjacent" as used in the context of two nucleic acid sequences refers to two sequences that directly abut each other as part of the same nucleic acid molecule and are not separated by one or more nucleotides. Accordingly, sequences are immediately adjacent, when the nucleotide at the 3 '-end of one of the sequences is directly connected to nucleotide at the 5'-end of the other sequence via a phosphodiester bond.

[00108] The term "linker," as used herein, refers to a chemical group or a molecule linking two molecules or moieties, e.g., two domains of a fusion protein, such as, for example, a nuclease-inactive Cas9 domain and a effector domain (e.g., a deaminase domain). In some embodiments, a linker joins a gRNA binding domain of an RNA-programmable nuclease, including a Cas9 nuclease domain, and the catalytic domain of a nucleic-acid editing protein. In some embodiments, a linker joins a dCas9 and a nucleic-acid editing protein. Typically, the linker is positioned between, or flanked by, two groups, molecules, or other moieties and connected to each one via a covalent bond, thus connecting the two. In some embodiments, the linker is an amino acid or a plurality of amino acids (e.g., a peptide or protein). In some embodiments, the linker is an organic molecule, group, polymer, or chemical moiety. In some embodiments, the linker is 5-100 amino acids in length, for example, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 30-35, 35-40, 40-45, 45-50, 50-60, 60-70, 70-80, 80-90, 90-100, 100-150, or 150-200 amino acids in length. Longer or shorter linkers are also contemplated.

[00109] The term "mutation," as used herein, refers to a substitution of a residue within a sequence, e.g., a nucleic acid or amino acid sequence, with another residue, or a deletion or insertion of one or more residues within a sequence. Mutations are typically described herein by identifying the original residue followed by the position of the residue within the sequence and by the identity of the newly substituted residue. Various methods for making the amino acid substitutions (mutations) provided herein are well known in the art, and are provided by, for example, Green and Sambrook, Molecular Cloning: A Laboratory Manual (4^th ed., Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y. (2012)).

[00110] The terms "nucleic acid" and "nucleic acid molecule," as used herein, refer to a compound comprising a nucleobase and an acidic moiety, e.g., a nucleoside, a nucleotide, or a polymer of nucleotides. Typically, polymeric nucleic acids, e.g., nucleic acid molecules comprising three or more nucleotides are linear molecules, in which adjacent nucleotides are linked to each other via a phosphodiester linkage. In some embodiments, "nucleic acid" refers to individual nucleic acid residues {e.g. nucleotides and/or nucleosides). In some embodiments, "nucleic acid" refers to an oligonucleotide chain comprising three or more individual nucleotide residues. As used herein, the terms "oligonucleotide" and

"polynucleotide" can be used interchangeably to refer to a polymer of nucleotides {e.g., a string of at least three nucleotides). In some embodiments, "nucleic acid" encompasses RNA as well as single and/or double-stranded DNA. Nucleic acids may be naturally occurring, for example, in the context of a genome, a transcript, mRNA, tRNA, rRNA, siRNA, snRNA, a plasmid, cosmid, chromosome, chromatid, or other naturally occurring nucleic acid molecule. On the other hand, a nucleic acid molecule may be a non-naturally occurring molecule, e.g., a recombinant DNA or RNA, an artificial chromosome, an engineered genome, or fragment thereof, or a synthetic DNA, RNA, DNA/RNA hybrid, or including non-naturally occurring nucleotides or nucleosides. Furthermore, the terms "nucleic acid," "DNA," "RNA," and/or similar terms include nucleic acid analogs, e.g., analogs having other than a phosphodiester backbone. Nucleic acids can be purified from natural sources, produced using recombinant expression systems and optionally purified, chemically synthesized, etc. Where appropriate, e.g., in the case of chemically synthesized molecules, nucleic acids can comprise nucleoside analogs such as analogs having chemically modified bases or sugars, and backbone modifications. A nucleic acid sequence is presented in the 5' to 3 ' direction unless otherwise indicated. In some embodiments, a nucleic acid is or comprises natural nucleosides {e.g. adenosine, thymidine, guanosine, cytidine, uridine, deoxyadenosine, deoxythymidine, deoxyguanosine, and deoxy cytidine); nucleoside analogs {e.g., 2-aminoadenosine, 2- thiothymidine, inosine, pyrrolo-pyrimidine, 3-methyl adenosine, 5-methylcytidine, 2- aminoadenosine, C5-bromouridine, C5-fluorouridine, C5-iodouridine, C5-propynyl-uridine, C5-propynyl-cytidine, C5-methylcytidine, 2-aminoadenosine, 7-deazaadenosine, 7- deazaguanosine, 8-oxoadenosine, 8-oxoguanosine, 0(6)-methylguanine, and 2-thiocytidine); chemically modified bases; biologically modified bases (e.g., methylated bases); intercalated bases; modified sugars (e.g., 2'-fluororibose, ribose, 2'-deoxyribose, arabinose, and hexose); and/or modified phosphate groups (e.g., phosphorothioates and 5'-N-phosphoramidite linkages). In some embodiments, an RNA is an RNA associated with the Cas9 system. For example, the RNA may be a CRISPR RNA (crRNA), a trans-encoded small RNA

(tracrRNA), a single guide RNA (sgRNA), or a guide RNA (gRNA).

[00111] The term "proliferative disease," as used herein, refers to any disease in which cell or tissue homeostasis is disturbed in that a cell or cell population exhibits an abnormally elevated proliferation rate. Proliferative diseases include hyperproliferative diseases, such as pre-neoplastic hyperplastic conditions and neoplastic diseases. Neoplastic diseases are characterized by an abnormal proliferation of cells and include both benign and malignant neoplasias. Malignant neoplasia is also referred to as cancer.

[00112] The terms "protein," "peptide," and "polypeptide" are used interchangeably herein, and refer to a polymer of amino acid residues linked together by peptide (amide) bonds. The terms refer to a protein, peptide, or polypeptide of any size, structure, or function. Typically, a protein, peptide, or polypeptide will be at least three amino acids long. A protein, peptide, or polypeptide may refer to an individual protein or a collection of proteins. One or more of the amino acids in a protein, peptide, or polypeptide may be modified, for example, by the addition of a chemical entity such as a carbohydrate group, a hydroxyl group, a phosphate group, a farnesyl group, an isofarnesyl group, a fatty acid group, a linker for conjugation, functionalization, or other modification, etc. A protein, peptide, or polypeptide may also be a single molecule or may be a multi-molecular complex. A protein, peptide, or polypeptide may be just a fragment of a naturally occurring protein or peptide. A protein, peptide, or polypeptide may be naturally occurring, recombinant, or synthetic, or any combination thereof. The term "fusion protein" as used herein refers to a hybrid polypeptide which comprises protein domains from at least two different proteins. One protein may be located at the amino-terminal (N-terminal) portion of the fusion protein or at the carboxy- terminal (C-terminal) protein thus forming an "amino-terminal fusion protein" or a "carboxy- terminal fusion protein," respectively. A protein may comprise different domains, for example, a nucleic acid binding domain (e.g., the gRNA binding domain of Cas9 that directs the binding of the protein to a target site) and a nucleic acid cleavage domain or a catalytic domain of a nucleic-acid editing protein. In some embodiments, a protein comprises a proteinaceous part, e.g., an amino acid sequence constituting a nucleic acid binding domain, and an organic compound, e.g., a compound that can act as a nucleic acid cleavage agent. In some embodiments, a protein is in a complex with, or is in association with, a nucleic acid, e.g., RNA. Any of the proteins provided herein may be produced by any method known in the art. For example, the proteins provided herein may be produced via recombinant protein expression and purification, which is especially suited for fusion proteins comprising a peptide linker. Methods for recombinant protein expression and purification are well known, and include those described by Green and Sambrook, Molecular Cloning: A Laboratory Manual (4^th ed., Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y. (2012)), the entire contents of which are incorporated herein by reference.

[00113] The term "RNA-programmable nuclease," and "RNA-guided nuclease" are used interchangeably herein and refer to a nuclease that forms a complex with {e.g., binds or associates with) one or more RNA that is not a target for cleavage. In some embodiments, an RNA-programmable nuclease, when in a complex with an RNA, may be referred to as a nuclease:RNA complex. Typically, the bound RNA(s) is referred to as a guide RNA

(gRNA). gRNAs can exist as a complex of two or more RNAs, or as a single RNA molecule. gRNAs that exist as a single RNA molecule may be referred to as single-guide RNAs (sgRNAs), though "gRNA" is used interchangeably to refer to guide RNAs that exist as either single molecules or as a complex of two or more molecules. Typically, gRNAs that exist as single RNA species comprise two domains: (1) a domain that shares homology to a target nucleic acid {e.g., and directs binding of a Cas9 complex to the target); and (2) a domain that binds a Cas9 protein. In some embodiments, domain (2) corresponds to a sequence known as a tracrRNA, and comprises a stem-loop structure. For example, in some embodiments, domain (2) is identical or homologous to a tracrRNA as provided in Jinek et al, Science 337:816-821(2012), the entire contents of which is incorporated herein by reference. Other examples of gRNAs {e.g., those including domain 2) can be found in U.S. Provisional Patent Application, U.S. S.N. 61/874,682, filed September 6, 2013, entitled "Switchable Cas9 Nucleases and Uses Thereof," and U.S. Provisional Patent Application, U.S.S.N. 61/874,746, filed September 6, 2013, entitled "Delivery System For Functional Nucleases," the entire contents of each are hereby incorporated by reference in their entirety. In some embodiments, a gRNA comprises two or more of domains (1) and (2), and may be referred to as an "extended gRNA." For example, an extended gRNA will, e.g., bind two or more Cas9 proteins and bind a target nucleic acid at two or more distinct regions, as described herein. The gRNA comprises a nucleotide sequence that complements a target site, which mediates binding of the nuclease/RNA complex to said target site, providing the sequence specificity of the nuclease:RNA complex. In some embodiments, the RNA- programmable nuclease is the (CRISPR-associated system) Cas9 endonuclease, for example Cas9 (Csnl) from Streptococcus pyogenes (see, e.g., "Complete genome sequence of an Ml strain of Streptococcus pyogenes." Ferretti J. J., McShan W.M., Ajdic D.J., Savic D.J., Savic G., Lyon K., Primeaux C, Sezate S., Suvorov A.N., Kenton S., Lai H.S., Lin S.P., Qian Y., Jia H.G., Najar F.Z., Ren Q., Zhu H., Song L., White J., Yuan X., Clifton S.W., Roe B.A., McLaughlin R.E., Proc. Natl. Acad. Sci. U.S.A. 98:4658-4663 (2001); "CRISPR RNA maturation by trans-encoded small RNA and host factor RNase III." Deltcheva E., Chylinski K., Sharma CM., Gonzales K., Chao Y., Pirzada Z.A., Eckert M.R., Vogel J., Charpentier E., Nature 471 : 602-607 (2011); and "A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity." Jinek M., Chylinski K., Fonfara I, Hauer M., Doudna J. A., Charpentier E. Science 337:816-821 (2012), the entire contents of each of which are incorporated herein by reference.

[00114] Because RNA-programmable nucleases {e.g., Cas9) use RNA:DNA

hybridization to target DNA cleavage sites, these proteins are able to be targeted, in principle, to any sequence specified by the guide RNA. Methods of using RNA-programmable nucleases, such as Cas9, for site-specific cleavage {e.g., to modify a genome) are known in the art (see e.g., Cong, L. et al. Multiplex genome engineering using CRISPR/Cas systems. Science 339, 819-823 (2013); Mali, P. et al. RNA-guided human genome engineering via Cas9. Science 339, 823-826 (2013); Hwang, W.Y. et al. Efficient genome editing in zebrafish using a CRISPR-Cas system. Nature biotechnology 31, 227-229 (2013); Jinek, M. et al. RNA-programmed genome editing in human cells. eLife 2, e00471 (2013); Dicarlo, J.E. et al. Genome engineering in Saccharomyces cerevisiae using CRISPR-Cas systems. Nucleic acids research (2013); Jiang, W. et al. RNA-guided editing of bacterial genomes using CRISPR- Cas systems. Nature biotechnology 31, 233-239 (2013); the entire contents of each of which are incorporated herein by reference).

[00115] The term "subject," as used herein, refers to an individual organism, for example, an individual mammal. In some embodiments, the subject is a human. In some embodiments, the subject is a non-human mammal. In some embodiments, the subject is a non-human primate. In some embodiments, the subject is a rodent. In some embodiments, the subject is a sheep, a goat, a cattle, a cat, or a dog. In some embodiments, the subject is a vertebrate, an amphibian, a reptile, a fish, an insect, a fly, or a nematode. In some

embodiments, the subject is a research animal. In some embodiments, the subject is genetically engineered, e.g., a genetically engineered non-human subject. The subject may be of either sex, of any age, and at any stage of development.

[00116] The term "target site" refers to a sequence within a nucleic acid molecule that is deaminated by a deaminase or a fusion protein comprising a deaminase (e.g., a dCas9- deaminase fusion protein provided herein).

[00117] The terms "treatment," "treat," and "treating," refer to a clinical intervention aimed to reverse, alleviate, delay the onset of, or inhibit the progress of a disease or disorder, or one or more symptoms thereof, as described herein. As used herein, the terms "treatment," "treat," and "treating" refer to a clinical intervention aimed to reverse, alleviate, delay the onset of, or inhibit the progress of a disease or disorder, or one or more symptoms thereof, as described herein. In some embodiments, treatment may be administered after one or more symptoms have developed and/or after a disease has been diagnosed. In other embodiments, treatment may be administered in the absence of symptoms, e.g., to prevent or delay onset of a symptom or inhibit onset or progression of a disease. For example, treatment may be administered to a susceptible individual prior to the onset of symptoms (e.g., in light of a history of symptoms and/or in light of genetic or other susceptibility factors). Treatment may also be continued after symptoms have resolved, for example, to prevent or delay their recurrence.

[00118] The term "recombinant" as used herein in the context of proteins or nucleic acids refers to proteins or nucleic acids that do not occur in nature, but are the product of human engineering. For example, in some embodiments, a recombinant protein or nucleic acid molecule comprises an amino acid or nucleotide sequence that comprises at least one, at least two, at least three, at least four, at least five, at least six, or at least seven mutations as compared to any naturally occurring sequence.

[00119] The term "nucleic acid editing enzyme" as used herein refers to proteins that are able to modify a nucleic acids or one or more nucleotide bases of a nucleic acid. For example, in some embodiments, a nucleic acid editing enzyme is a deaminase, which can catalyze C to T or G to A changes. Other suitable nucleid acid editing enzyme that may be used in accordance with this disclosure include, without limitation, a nuclease, nickase, recombinase, deaminase, methyltransferase, methylase, acetylase, or acetyltransferase.

DETAILED DESCRIPTION OF CERTAIN EMBOD EVENTS OF THE INVENTION

[00120] Some aspects of this disclosure provide recombinant Cas9 proteins that efficiently target DNA sequences that do not comprise the canonical PAM sequence (5 '- NGG-3 ', where N is any nucleotide, for example A, T, G, or C) at their 3 '-ends. In some embodiments, the Cas9 proteins provided herein comprise one or more mutations identified in directed evolution experiments using a target sequence library comprising randomized PAM sequences. The recombinant non-PAM restricted Cas9 proteins provided herein are useful for targeting DNA sequences that do not comprise the canonical PAM sequence at their 3 '-end and thus greatly extend the usefulness of Cas9 technology for gene editing.

[00121] Some aspects of this disclosure provide fusion proteins that comprise a Cas9 protein and an effector domain, for example, a DNA-editing domain, such as, e.g., a deaminase domain. The deamination of a nucleobase by a deaminase can lead to a point mutation at the specific residue, which is referred to herein as nucleic acid editing. Fusion proteins comprising a Cas9 protein or variant thereof and a DNA-editing domain can thus be used for the targeted editing of nucleic acid sequences. Such fusion proteins are useful for targeted editing of DNA in vitro, e.g., for the generation of mutant cells or animals; for the introduction of targeted mutations, e.g., for the correction of genetic defects in cells ex vivo, e.g., in cells obtained from a subject that are subsequently re-introduced into the same or another subject; and for the introduction of targeted mutations, e.g., the correction of genetic defects or the introduction of deactivating mutations in disease-associated genes in a subject in vivo. Typically, the Cas9 protein of the fusion proteins described herein does not have any nuclease activity but instead is a Cas9 fragment or a dCas9 protein. Methods for the use of Cas9 fusion proteins as described herein are also provided.

[00122] Non-limiting, exemplary nuclease-inactive Cas9 proteins are provided herein.

One exemplary suitable nuclease-inactive Cas9 protein is the D10A/H840A Cas9 protein mutant:

MDKKYSIGLAIGTNSVGWAVITDEYKVPSKKFKVLGNTDRHSIKKNLIGALLFDSGETAEATRLKRTARRRYTRR KNRICYLQEIFSNEMAKVDDSFFHRLEESFLVEEDKKHERHPIFGNIVDEVAYHEKYPTIYHLRKKLVDSTDKAD LRLIYLALAHMIKFRGHFLIEGDLNPDNSDVDKLFIQLVQTYNQLFEENPINASGVDAKAILSARLSKSRRLENL IAQLPGEKKNGLFGNLIALSLGLTPNFKSNFDLAEDAKLQLSKDTYDDDLDNLLAQIGDQYADLFLAAKNLSDAI LLSDILR TEITKAPLSASMIKRYDEHHQDLTLLKALVRQQLPEKYKEIFFDQSKNGYAGYIDGGASQEEFYKF IKPILEKMDGTEELLVKLNREDLLRKQRTFDNGSIPHQIHLGELHAILRRQEDFYPFLKDNREKIEKILTFRIPY YVGPLARGNSRFAWMTRKSEETITPWNFEEWDKGASAQSFIERMTNFDKNLPNEKVLPKHSLLYEYFTVYNELT KVKYVTEGMRKPAFLSGEQKKAIVDLLFKTNRKVTVKQLKEDYFKKIECFDSVEISGVEDRFNASLGTYHDLLKI IKDKDFLDNEENEDILEDIVLTLTLFEDREMIEERLKTYAHLFDDKVMKQLKRRRYTGWGRLSRKLINGIRDKQS GKTILDFLKSDGFANRNFMQLIHDDSLTFKEDIQKAQVSGQGDSLHEHIANLAGSPAIKKGILQTVKWDELVKV MGRHKPENIVIEMARENQTTQKGQKNSRERMKRIEEGIKELGSQILKEHPVENTQLQNEKLYLYYLQNGRDMYVD QELDINRLSDYDVDAIVPQSFLKDDSIDNKVLTRSDKNRGKSDNVPSEEWKKMKNYWRQLLNAKLITQRKFDNL TKAERGGLSELDKAGFIKRQLVETRQITKHVAQILDSRMNTKYDENDKLIREVKVITLKSKLVSDFRKDFQFYKV REINNYHHAHDAYLNAWGTALIKKYPKLESEFVYGDYKVYDVRKMIAKSEQEIGKATAKYFFYSNIMNFFKTEI TLANGEIRKRPLIETNGETGEIVWDKGRDFATVRKVLSMPQ IVKKTEVQTGGFSKESILPKRNSDKLIARKKD WDPKKYGGFDSPTVAYSVLWAKVEKGKSKKLKSVKELLGITIMERSSFEKNPIDFLEAKGYKEVKKDLIIKLPK YSLFELENGRKRMLASAGELQKGNELALPSKY FLYLASHYEKLKGSPEDNEQKQLFVEQHKHYLDEIIEQISE FSKRVILADANLDKVLSAYNKHRDKPIREQAENIIHLFTLTNLGAPAAFKYFDTTIDRKRYTSTKEVLDATLIHQ

siTGLYETRiDLSQLGGD (SEQ ID NO:262; see, e.g., Qi et al, Repurposing CRISPR as an RNA-guided platform for sequence-specific control of gene expression. Cell. 2013;

152(5): 1173-83, the entire contents of which are incorporated herein by reference).

[00123] Additional suitable nuclease-inactive Cas9 proteins will be apparent to those of skill in the art based on this disclosure. Such additional exemplary suitable nuclease- inactive Cas9 proteins include, but are not limited to, D10A, D839A, H840A, N863A, D10A/D839A, D10A/H840A, D10A/N863A, D839A/H840A, D839A/N863A,

D10A/D839A/H840A, and D10A/D839A/H840A/N863A mutant proteins (See, e.g., Prashant et al, CAS9 transcriptional activators for target specificity screening and paired nickases for cooperative genome engineering. Nature Biotechnology . 2013; 31(9): 833-838, the entire contents of which are incorporated herein by reference).

Recombinant Cas9 proteins

[00124] Some aspects of this disclosure provide recombinant Cas9 proteins comprising an amino acid sequence that is at least 80%, at least 85%, at least 90%, at least 92%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or at least 99.5% identical to the amino acid sequence of Cas9 as provided by any of the sequences provided in SEQ ID NOs: 10-262, wherein the Cas9 protein comprises a RuvC and an HNH domain, wherein the amino acid sequence of the Cas9 protein comprises at least one, at least two, at least three, at least four, at least five, at least six, or at least seven mutations at an amino acid residue selected from the group consisting of amino acid residues 122, 137, 182, 262, 294, 409, 480, 543, 660, 694, 1219, and 1329 of the amino acid sequence provided in SEQ ID NO: 9, or in a corresponding amino acid residue in any of the amino acid sequences provided in SEQ ID NOs: 10-262, and wherein the amino acid sequence of the recombinant Cas9 protein is not identical to the amino acid sequence of a naturally occurring Cas9 protein.

[00125] In some embodiments, the amino acid sequence of the Cas9 protein comprises at least one, at least two, at least three, at least four, at least five, at least six, or at least seven mutations selected from the group consisting of X262T, X294R, X409I, X480K, X543D, X694I, and X1219V of the amino acid sequence provided in SEQ ID NO: 9, or a

corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10- 262, wherein X represents any amino acid at the corresponding position.

[00126] In some embodiments, the amino acid sequence of the Cas9 protein comprises at least one, at least two, at least three, at least four, at least five, at least six, or at least seven mutations selected from the group consisting of A262T, K294R, S409I, E480K, E543D, M694I, or E1219V of the amino acid sequence provided in SEQ ID NO: 9, or a

corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10- 262. In some embodiments, the amino acid sequence of the Cas9 protein comprises an X1219V mutation of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262. In some embodiments, the amino acid sequence of the Cas9 protein comprises an E1219V mutation of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262.

[00127] In some embodiments, the amino acid sequence of the HNH domain is at least 80%, at least 85%, at least 90%, at least 92%, at least 95%, at least 96%, at least 97%, at least 98%), at least 99%, or at least 99.5% identical to the amino acid sequence of the HNH domain of SEQ ID NO: 9. In some embodiments, the amino acid sequence of the RuvC domain is at least 80%, at least 85%, at least 90%, at least 92%, at least 95%, at least 96%, at least 97%, at least 98%), at least 99%, or at least 99.5% identical to the amino acid sequence of the RuvC domain of any of SEQ ID NOs: 10-262. In some embodiments, the amino acid sequence of the RuvC domain is at least 80%, at least 85%, at least 90%, at least 92%, at least 95%, at least 96%), at least 97%, at least 98%, at least 99%, or at least 99.5% identical to the amino acid sequence of the RuvC domain of SEQ ID NO: 9. In some embodiments, the Cas9 protein comprises a D10A and/or a H840A mutation of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262.

Recombinant Cas9 proteins with activity on non-canonical PAMs

[00128] Some aspects of this disclosure provide recombinant Cas9 proteins comprising an amino acid sequence that is at least 90% identical to the amino acid sequence of

Streptococcus pyogenes Cas9 as provided by SEQ ID NO: 9, comprising the RuvC and HNH domains of SEQ ID NO: 9, wherein the amino acid sequence of the Cas9 protein comprises at least one, at least two, at least three, at least four, at least five, at least six, or at least seven mutations in an amino acid residue selected from the group consisting of amino acid residues 122, 137, 182, 262, 294, 409, 480, 543, 660, 694, 1219, and 1329 of the amino acid sequence provided in SEQ ID NO: 9, wherein the amino acid sequence of the recombinant Cas9 protein is not identical to the amino acid sequence of a naturally occurring Cas9 protein, and wherein the recombinant Cas9 protein exhibits activity (e.g., increased activity) on a target sequence that does not comprise the canonical PAM (5'-NGG-3 ') at its 3 '-end as compared to Streptococcus pyogenes Cas9 as provided by SEQ ID NO: 9.

[00129] In some embodiments, the Cas9 protein exhibits activity on a target sequence having a 3 '-end that is not directly adjacent to the canonical PAM sequence (5'-NGG-3 ') that is at least 2-fold, at least 3-fold, at least 5-fold, at least 10-fold, at least 50-fold, at least 100- fold, at least 500-fold, at least 1,000-fold, at least 5,000-fold, at least 10,000-fold, at least 50,000-fold, at least 100,000-fold, at least 500,000-fold, or at least 1,000,000-fold increased as compared to the activity of Streptococcus pyogenes Cas9 as provided by SEQ ID NO: 9 on the same target sequence. In some embodiments, the 3 '-end of the target sequence is directly adjacent to an AGC, GAG, TTT, GTG, or CAA sequence. In some embodiments, the Cas9 protein activity is measured by a nuclease assay, a deamination assay, or a transcriptional activation assay. In some embodiments, the transcriptional activation assay is a reporter activation assay, such as a GFP activation assay. Exemplary methods for measuring binding activity (e.g., of Cas9) using transcriptional activation assays are known in the art and would be apparent to the skilled artisan. For example, methods for measuring Cas9 activity using the tripartite activator VPR have been described in Chavez A., et al., "Highly efficient Cas9- mediated transcriptional programming." Nature Methods 12, 326-328 (2015); the entire contents of which are incorporated by reference herein.

[00130] In some embodiments, the amino acid sequence of the Cas9 protein comprises at least one, at least two, at least three, at least four, at least five, at least six, or at least seven mutations selected from the group consisting of X262T, X294R, X409I, X480K, X543D, X694I, and X1219V of the amino acid sequence provided in SEQ ID NO: 9, or a

corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10- 262, wherein X represents any amino acid at the corresponding position.

[00131] In some embodiments, the amino acid sequence of the Cas9 protein comprises at least one, at least two, at least three, at least four, at least five, at least six, or at least seven mutations selected from the group consisting of A262T, K294R, S409I, E480K, E543D, M694I, or E1219V of the amino acid sequence provided in SEQ ID NO: 9, or a

corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10- 262. In some embodiments, the amino acid sequence of the Cas9 protein comprises an X1219V mutation of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262. In some embodiments, the amino acid sequence of the Cas9 comprises an X1219V mutation of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262.

[00132] In some embodiments, the amino acid sequence of the HNH domain is at least 80%, at least 85%, at least 90%, at least 92%, at least 95%, at least 96%, at least 97%, at least 98%), at least 99%, or at least 99.5% identical to the amino acid sequence of the HNH domain of any of SEQ ID NOs: 2, 4, or 9. In some embodiments, the amino acid sequence of the RuvC domain is at least 80%, at least 85%, at least 90%, at least 92%, at least 95%, at least 96%), at least 97%, at least 98%, at least 99%, or at least 99.5% identical to the amino acid sequence of the RuvC domain of any of SEQ ID NOs: 10-262. In some embodiments, the Cas9 protein comprises a D10A and/or a H840A mutation of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262.

[00133] Some aspects of this disclosure provide recombinant Cas9 proteins comprising an amino acid sequence that is at least 90% identical to the amino acid sequence of

Streptococcus pyogenes Cas9 as provided by SEQ ID NO: 9, comprising the RuvC and HNH domains of SEQ ID NO: 9, wherein the amino acid sequence of the Cas9 protein comprises at least one, at least two, at least three, at least four, at least five, at least six, or at least seven mutations in an amino acid residue selected from the group consisting of amino acid residues 122, 137, 182, 262, 294, 409, 480, 543, 660, 694, 1219, and 1329 of the amino acid sequence provided in SEQ ID NO: 9, wherein the amino acid sequence of the recombinant Cas9 protein is not identical to the amino acid sequence of a naturally occurring Cas9 protein, and wherein the recombinant Cas9 protein exhibits an increased activity on a target sequence that does not comprise the canonical PAM (5'-NGG-3') at its 3 '-end as compared to Streptococcus pyogenes Cas9 as provided by SEQ ID NO: 9. In some embodiments, the amino acid sequence of the RuvC domain is at least 80%, at least 85%, at least 90%, at least 92%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or at least 99.5% identical to the amino acid sequence of the RuvC domain of any of SEQ ID NOs: 2, 4, or 9. In some embodiments, the Cas9 protein comprises a D10A and a H840A mutation of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262.

[00134] Some aspects of this disclosure provide recombinant Cas9 proteins comprising an amino acid sequence that is at least 90% identical to the amino acid sequence of Streptococcus pyogenes Cas9 as provided by SEQ ID NO: 9, comprising the RuvC and HNH domains of SEQ ID NO: 9, wherein the amino acid sequence of the Cas9 protein comprises at least one, at least two, at least three, at least four, at least five, at least six, or at least seven mutations in an amino acid residue selected from the group consisting of amino acid residues 122, 137, 182, 262, 294, 409, 480, 543, 660, 694, 1219, and 1329 of the amino acid sequence provided in SEQ ID NO: 9, wherein the amino acid sequence of the recombinant Cas9 protein is not identical to the amino acid sequence of a naturally occurring Cas9 protein, and wherein the recombinant Cas9 protein exhibits an increased activity on a target sequence that does not comprise the canonical PAM (5'-NGG-3') at its 3 '-end as compared to Streptococcus pyogenes Cas9 as provided by SEQ ID NO: 9. In some embodiments, the amino acid sequence of the RuvC domain is at least 80%, at least 85%, at least 90%, at least 92%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or at least 99.5% identical to the amino acid sequence of the RuvC domain of any of SEQ ID NOs: 2, 4, or 9. In some embodiments, the Cas9 protein comprises a D10A mutation of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262. In some embodiments, the Cas9 further comprises a histidine residue at position 840 as provided in SEQ ID NO: 9, or a corresponding histidine residue in any of the amino acid sequences provided in SEQ ID NOs: 10-262. Without wishing to be bound by any particular theory, the presence of the catalytic residue H840 allows Cas9 to cleave the non-targeted strand, i.e., the strand bound by the sgRNA. In some embodiments, a Cas9 having an amino acid residue other than histidine at position 840 of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding amino acid sequence provided in SEQ ID NOs: 10-262 may be changed or reverted such that amino acid residue 840 of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding amino acid sequence provided in SEQ ID NOs: 10-262 is histidine.

[00135] Some aspects of this disclosure provide recombinant Cas9 proteins comprising an amino acid sequence that is at least 90% identical to the amino acid sequence of

Streptococcus pyogenes Cas9 as provided by SEQ ID NO: 9, comprising the RuvC and HNH domains of SEQ ID NO: 9; wherein the amino acid sequence of the Cas9 protein comprises at least one, at least two, at least three, at least four, at least five, at least six, or at least seven mutations in an amino acid residue selected from the group consisting of amino acid residues 262, 267, 294, 405, 409, 480, 543, 694, 1219, 1224, and 1256 of the amino acid sequence provided in SEQ ID NO: 9; wherein the amino acid sequence of the recombinant Cas9 protein is not identical to the amino acid sequence of a naturally occurring Cas9 protein; and wherein the recombinant Cas9 protein exhibits activity (e.g., increased activity) on a target sequence that does not comprise the canonical PAM (5'-NGG-3 ') at its 3 '-end as compared to Streptococcus pyogenes Cas9 as provided by SEQ ID NO: 9.

[00136] In some embodiments, the Cas9 protein exhibits an activity on a target sequence having a 3 '-end that is not directly adjacent to the canonical PAM sequence (5'- NGG-3 ') that is at least 2-fold, at least 3-fold, at least 5-fold, at least 10-fold, at least 50-fold, at least 100-fold, at least 500-fold, at least 1,000-fold, at least 5,000-fold, at least 10,000-fold, at least 50,000-fold, at least 100,000-fold, at least 500,000-fold, or at least 1,000,000-fold increased as compared to the activity of Streptococcus pyogenes Cas9 as provided by SEQ ID NO: 9 on the same target sequence. In some embodiments, the 3 '-end of the target sequence is directly adjacent to an AAA, AAC, AAG, AAT, CAA, CAC, CAG, CAT, GAA, GAC, GAG, GAT, TAA, TAC, TAG, TAT, ACA, ACC, ACG, ACT, CCA, CCC, CCG, CCT, GCA, GCC, GCG, GCT, TCA, TCC, TCG, TCT, AGA, AGC, AGT, CGA, CGC, CGT, GGA, GGC, GGT, TGA, TGC, TGT, ATA, ATC, ATG, ATT, CTA, CTC, CTG, CTT, GTA, GTC, GTG, GTT, TTA, TTC, TTG, or TTT PAM sequence.

[00137] In some embodiments, the amino acid sequence of the Cas9 protein comprises at least one, at least two, at least three, at least four, at least five, at least six, or at least seven mutations selected from the group consisting of X262T, X267G, X294R, X405I, X409I, X480K, X543D, X694I, X1219V, X1224K, X1256K, and X1362P of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262, wherein X represents any amino acid at the corresponding position.

[00138] In some embodiments, the amino acid sequence of the Cas9 protein comprises at least one, at least two, at least three, at least four, at least five, at least six, or at least seven mutations selected from the group consisting of A262T, S267G, K294R, F405I, S409I, E480K, E543D, M694I, E1219V, N1224K, Q1256K, and L1362P of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262. In some embodiments, the amino acid sequence of the Cas9 protein comprises an X1219V mutation of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262. In some embodiments, the amino acid sequence of the Cas9 protein comprises an E1219V mutation of the amino acid sequence provided in SEQ ID NO: 9, or a

corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10- 262. [00139] In some embodiments, the amino acid sequence of the Cas9 protein comprises an X480K mutation of the amino acid sequence provided in SEQ ID NO: 9, or a

corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10- 262. In some embodiments, the amino acid sequence of the Cas9 protein comprises an E480K mutation of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262.

[00140] In some embodiments, the amino acid sequence of the Cas9 protein comprises an X543D mutation of the amino acid sequence provided in SEQ ID NO: 9, or a

corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10- 262. In some embodiments, the amino acid sequence of the Cas9 protein comprises an E543D mutation of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262.

[00141] In some embodiments, the amino acid sequence of the Cas9 protein comprises the combination of mutations selected from the group consisting of (X480K, X543D, and X1219V); (X262T, X409I, X480K, X543D, X694I, and X1219V); (X294R, X480K, X543D, X1219V, X1256K, and X1362P); (X294R, X480K, X543D, X1219V, and X1256K);

(X267G, X294R, X480K, X543D, X1219V, X1224K, and X1256K); and (X262T, X405I, X409I, X480K, X543D, X694I, and X1219V) of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262. In some embodiments, the amino acid sequence of the Cas9 protein comprises the combination of mutations selected from the group consisting of (E480K, E543D, and E1219V); (A262T, S409I, E480K, E543D, M694I, and E1219V); (K294R, E480K, E543D, E1219V, Q1256K, and L1362P); (K294R, E480K, E543D, E1219V, and Q1256K); (S267G, K294R, E480K, E543DE1219V, N1224K, and Q1256K); and (A262T, F405I, S409I, E480K, E543D, M694I, and E1219V) of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262.

[00142] In some embodiments, the amino acid sequence of the HNH domain is at least 80%, at least 85%, at least 90%, at least 92%, at least 95%, at least 96%, at least 97%, at least 98%), at least 99%, or at least 99.5% identical to the amino acid sequence of the HNH domain of any of SEQ ID NOs: 2, 4, or 9. In some embodiments, the amino acid sequence of the RuvC domain is at least 80%, at least 85%, at least 90%, at least 92%, at least 95%, at least 96%), at least 97%, at least 98%, at least 99%, or at least 99.5% identical to the amino acid sequence of the RuvC domain of any of SEQ ID NOs: 2, 4, or 9. In some embodiments, the Cas9 protein comprises a D10A and/or a H840A mutation of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262. In some embodiments, the Cas9 protein comprises a D10A and an H840A mutation of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10- 262. In some embodiments, the Cas9 protein comprises a D10A mutation of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262. In some embodiments, the Cas9 protein comprises an H840A mutation of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10- 262.

[00143] Some aspects of this disclosure provide recombinant Cas9 proteins comprising an amino acid sequence that is at least 90% identical to the amino acid sequence of

Streptococcus pyogenes Cas9 as provided by SEQ ID NO: 9, comprising the RuvC and HNH domains of SEQ ID NO: 9, wherein the amino acid sequence of the Cas9 protein comprises at least one, at least two, at least three, at least four, at least five, at least six, or at least seven mutations in an amino acid residue selected from the group consisting of amino acid residues 262, 267, 294, 405, 409, 480, 543, 694, 1219, 1224, 1256, and 1362 of the amino acid sequence provided in SEQ ID NO: 9, wherein the amino acid sequence of the recombinant Cas9 protein is not identical to the amino acid sequence of a naturally occurring Cas9 protein, and wherein the recombinant Cas9 protein exhibits increased activity on a target sequence that does not include the canonical PAM (5'-NGG-3') at its 3 '-end as compared to

Streptococcus pyogenes Cas9 as provided by SEQ ID NO: 9. In some embodiments, the amino acid sequence of the RuvC domain is at least 80%, at least 85%, at least 90%, at least 92%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or at least 99.5% identical to the amino acid sequence of the RuvC domain of any of SEQ ID NOs: 2, 4, or 9. In some embodiments, the Cas9 protein comprises a D10A and a H840A mutation of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262.

[00144] Some aspects of this disclosure provide recombinant Cas9 proteins comprising an amino acid sequence that is at least 90% identical to the amino acid sequence of

Streptococcus pyogenes Cas9 as provided by SEQ ID NO: 9, comprising the RuvC and HNH domains of SEQ ID NO: 9, wherein the amino acid sequence of the Cas9 protein comprises at least one, at least two, at least three, at least four, at least five, at least six, or at least seven mutations at an amino acid residue selected from the group consisting of amino acid residues 262, 267, 294, 405, 409, 480, 543, 694, 1219, 1224, 1256, and 1362 of the amino acid sequence provided in SEQ ID NO: 9, wherein the amino acid sequence of the recombinant Cas9 protein is not identical to the amino acid sequence of a naturally occurring Cas9 protein, and wherein the recombinant Cas9 protein exhibits increased activity on a target sequence that does not comprise the canonical PAM (5'-NGG-3 ') at its 3 '-end as compared to

Streptococcus pyogenes Cas9 as provided by SEQ ID NO: 9. In some embodiments, the amino acid sequence of the RuvC domain is at least 80%, at least 85%, at least 90%, at least 92%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or at least 99.5% identical to the amino acid sequence of the RuvC domain of any of SEQ ID NOs: 2, 4, or 9. In some embodiments, the Cas9 protein comprises a D10A mutation of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262. In some embodiments, the Cas9 further comprises a histidine residue at position 840 as provided in SEQ ID NO: 9, or a

corresponding histidine residue in any of the amino acid sequences provided in SEQ ID NOs: 10-262. Without wishing to be bound by any particular theory, the presence of the catalytic residue H840 allows Cas9 to cleave the non-targeted strand, i.e., the strand bound by the sgRNA. In some embodiments, a Cas9 having an amino acid residue other than histidine at position 840 of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding amino acid sequence provided in SEQ ID NOs: 10-262 may be changed or reverted such that amino acid residue 840 of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding amino acid sequence provided in SEQ ID NOs: 10-262 is histidine.

Cas9 fusion proteins

[00145] Some aspects of this disclosure provide fusion proteins comprising a Cas9 protein as provided herein that is fused to a second protein, or a "fusion partner", such as an effector domain, thus forming a fusion protein. In some embodiments, the effector domain is fused to the N-terminus of the Cas9 protein. In some embodiments, the effector domain is fused to the C-terminus of the Cas9 protein. In some embodiments, the Cas9 protein and the effector domain are fused to each other via a linker. Suitable strategies for generating fusion proteins according to aspects of this disclosure using linkers or without the use of linkers will also be apparent to those of skill in the art in view of the instant disclosure and the knowledge in the art. For example, Gilbert et al, CRISPR-mediated modular RNA-guided regulation of transcription in eukaryotes. Cell. 2013; 154(2):442-51, showed that C-terminal fusions of Cas9 with VP64 using 2 NLS's as a linker (SPKKKRKVEAS, SEQ ID NO: 284), can be employed for transcriptional activation. Mali et al, CAS9 transcriptional activators for target specificity screening and paired nickases for cooperative genome engineering. Nat

Biotechnol. 2013; 31(9):833-8, reported that C-terminal fusions with VP64 without linker can be employed for transcriptional activation. And Maeder et al, CRISPR RNA-guided activation of endogenous human genes. Nat Methods. 2013; 10: 977-979, reported that C- terminal fusions with VP64 using a Gly₄Ser (SEQ ID NO: 5) linker can be used as transcriptional activators. Recently, dCas9- Fokl nuclease fusions have successfully been generated and exhibit improved enzymatic specificity as compared to the parental Cas9 enzyme (In Guilinger JP, Thompson DB, Liu DR. Fusion of catalytically inactive Cas9 to Fokl nuclease improves the specificity of genome modification. Nat. Biotechnol. 2014; 32(6): 577-82, and in Tsai SQ, Wyvekens N, Khayter C, Foden JA, Thapar V, Reyon D, Goodwin MJ, Aryee MJ, Joung JK. Dimeric CRISPR RNA-guided Fokl nucleases for highly specific genome editing. Nat Biotechnol. 2014; 32(6):569-76. PMID: 24770325 a

SGSETPGTSESATPES (SEQ ID NO: 7) or a GGGGS„ (SEQ ID NO: 5) linker was used in FokI-dCas9 fusion proteins, respectively). In some embodiments, the linker comprises a (GGGGS)n (SEQ ID NO: 5), a (G)_n, an (EAAAK)_n (SEQ ID NO: 6), a (GGS)_n, an

SGSETPGTSESATPES (SEQ ID NO: 7), or an (XP)_n motif, or a combination of any of these, wherein n is independently an integer between 1 and 30. In some embodiments, the effector domain comprises an enzymatic domain. Suiable effector domains include, without limitation a nuclease, nickase, recombinase, deaminase, methyltransferase, methylase, acetylase, acetyltransferase, transcriptional activator, and transcriptional repressor.

[00146] The linker may be as simple as a covalent bond, or it may be a polymeric linker many atoms in length. In certain embodiments, the linker is a polpeptide or based on amino acids. In other embodiments, the linker is not peptide-like. In certain embodiments, the linker is a covalent bond {e.g., a carbon-carbon bond, disulfide bond, carbon-heteroatom bond, etc.). In certain embodiments, the linker is a carbon-nitrogen bond of an amide linkage. In certain embodiments, the linker is a cyclic or acyclic, substituted or unsubstituted, branched or unbranched aliphatic or heteroaliphatic linker. In certain embodiments, the linker is polymeric {e.g., polyethylene, polyethylene glycol, polyamide, polyester, etc.). In certain embodiments, the linker comprises a monomer, dimer, or polymer of aminoalkanoic acid. In certain embodiments, the linker comprises an aminoalkanoic acid {e.g., glycine, ethanoic acid, alanine, beta-alanine, 3-aminopropanoic acid, 4-aminobutanoic acid, 5- pentanoic acid, etc.). In certain embodiments, the linker comprises a monomer, dimer, or polymer of aminohexanoic acid (Ahx). In certain embodiments, the linker is based on a carbocyclic moiety (e.g., cyclopentane, cyclohexane). In other embodiments, the linker comprises a polyethylene glycol moiety (PEG). In other embodiments, the linker comprises amino acids. In certain embodiments, the linker comprises a peptide. In certain

embodiments, the linker comprises an aryl or heteroaryl moiety. In certain embodiments, the linker is based on a phenyl ring. The linker may included funtionalized moieties to facilitate attachment of a nucleophile (e.g., thiol, amino) from the peptide to the linker. Any electrophile may be used as part of the linker. Exemplary electrophiles include, but are not limited to, activated esters, activated amides, Michael acceptors, alkyl halides, aryl halides, acyl halides, and isothiocyanates.

[00147] In some embodiments, the effector domain comprises a effector enzyme.

Suitable effector enzymes that may be used in accordance with this disclosure include nucleases, nickases, recombinases, and deaminases. However additional effector enzymes would be apparent to the skilled artisan and are within the scope of this disclosure. In other embodiments, the effector domain comprises a domain that modulates transcriptional activity. Such transcriptional modulating domains may be, without limitation, a transcriptional activator or transcriptional repressor domain.

[00148] In some embodiments, the effector domain is a effector domain. In some embodiments, the effector domain is a deaminase domain. In some embodiments, the deaminase is a cytosine deaminase or a cytidine deaminase. In some embodiments, the deaminase is an apolipoprotein B mRNA-editing complex (APOBEC) family deaminase. In some embodiments, the deaminase is an APOBEC 1 deaminase. In some embodiments, the deaminase is an APOBEC2 deaminase. In some embodiments, the deaminase is an

APOBEC3 deaminase. In some embodiments, the deaminase is an APOBEC3A deaminase. In some embodiments, the deaminase is an APOBEC3D deaminase. In some embodiments, the deaminase is an APOBEC3E deaminase. In some embodiments, the deaminase is an APOBEC3F deaminase. In some embodiments, the deaminase is an APOBEC3G deaminase. In some embodiments, the deaminase is an APOBEC3H deaminase. In some embodiments, the deaminase is an APOBEC4 deaminase. In some embodiments, the deaminase is an activation-induced deaminase (AID).

[00149] In some embodiments, the effector domain is at least 80%, at least 85%, at least 90%, at least 92%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or at least 99.5% identical to the deaminase domain of any one of SEQ ID NOs: 263-281.

[00150] In some embodiments, the effector domain is a nuclease domain. In some embodiments, the nuclease domain is a Fokl DNA cleavage domain. In some embodiments, this disclosure provides dimers of the fusion proteins provided herein, e.g., dimers of fusion proteins may include a dimerizing nuclease domain.

[00151] In some embodiments, the Cas9 protein comprises an amino acid sequence that is at least 80%, at least 85%, at least 90%, at least 92%, at least 95%, at least 96%, at least 97%), at least 98%>, at least 99%, or at least 99.5% identical to the amino acid sequence of Cas9 as provided by any of the sequences provided in SEQ ID NOs: 10-262, wherein the Cas9 protein comprises a RuvC and an HNH domain, wherein the amino acid sequence of the Cas9 protein comprises at least one, at least two, at least three, at least four, at least five, at least six, or at least seven mutations in an amino acid residue selected from the group consisting of amino acid residues 122, 137, 182, 262, 294, 409, 480, 543, 660, 694, 1219, and 1329 of the amino acid sequence provided in SEQ ID NO: 9, or in a corresponding amino acid residue in any of the amino acid sequences provided in SEQ ID NOs: 10-262, and wherein the amino acid sequence of the recombinant Cas9 protein is not identical to the amino acid sequence of a naturally occurring Cas9 protein. In some embodiments, the Cas9 protein comprises an amino acid sequence that is at least 90% identical to the amino acid sequence of Streptococcus pyogenes Cas9 as provided by SEQ ID NO: 9, comprising the RuvC and HNH domains of SEQ ID NO: 9, wherein the amino acid sequence of the Cas9 protein comprises at least one, at least two, at least three, at least four, at least five, at least six, or at least seven mutations in an amino acid residue selected from the group consisting of amino acid residues 122, 137, 182, 262, 294, 409, 480, 543, 660, 694, 1219, and 1329 of the amino acid sequence provided in SEQ ID NO: 9, wherein the amino acid sequence of the recombinant Cas9 protein is not identical to the amino acid sequence of a naturally occurring Cas9 protein, and wherein the recombinant Cas9 protein exhibits activity on a target sequence that does not comprise the canonical PAM (5'-NGG-3') at its 3 '-end as compared to

Streptococcus pyogenes Cas9 as provided by SEQ ID NO: 9.

[00152] In some embodiments, the Cas9 protein comprises an amino acid sequence that is at least 80%, at least 85%, at least 90%, at least 92%, at least 95%, at least 96%, at least 97%), at least 98%, at least 99%, or at least 99.5% identical to the amino acid sequence of Cas9 as provided by any of the sequences provided in SEQ ID NOs: 10-262, wherein the Cas9 protein comprises a RuvC and an HNH domain, wherein the amino acid sequence of the Cas9 protein comprises at least one, at least two, at least three, at least four, at least five, at least six, or at least seven mutations in an amino acid residue selected from the group consisting of amino acid residues 262, 267, 294, 405, 409, 480, 543, 694, 1219, 1224, 1256, and 1362 of the amino acid sequence provided in SEQ ID NO: 9, or in a corresponding amino acid residue in any of the amino acid sequences provided in SEQ ID NOs: 10-262, and wherein the amino acid sequence of the recombinant Cas9 protein is not identical to the amino acid sequence of a naturally occurring Cas9 protein. In some embodiments, the Cas9 protein comprises an amino acid sequence that is at least 90% identical to the amino acid sequence of Streptococcus pyogenes Cas9 as provided by SEQ ID NO: 9, , comprising the RuvC and HNH domains of SEQ ID NO: 9, wherein the amino acid sequence of the Cas9 protein comprises at least one, at least two, at least three, at least four, at least five, at least six, or at least seven mutations in an amino acid residue selected from the group consisting of amino acid residues 262, 267, 294, 405, 409, 480, 543, 694, 1219, 1224, and 1256 of the amino acid sequence provided in SEQ ID NO: 9; wherein the amino acid sequence of the recombinant Cas9 protein is not identical to the amino acid sequence of a naturally occurring Cas9 protein; and wherein the recombinant Cas9 protein exhibits increased activity on a target sequence that does not include the canonical PAM (5'-NGG-3') at its 3 '-end, as compared to Streptococcus pyogenes Cas9 as provided by SEQ ID NO: 9.

[00153] Some aspects of this disclosure provide fusion proteins comprising (i) a nuclease-inactive Cas9 protein; and (ii) a effector domain. In some embodiments, the effector domain is a DNA-editing domain. In some embodiments, the effector domain possesses deaminase activity. In some embodiments, the effector domain comprises or is a deaminase domain. In some embodiments, the deaminase is a cytidine deaminase. In some embodiments, the deaminase is an apolipoprotein B mRNA-editing complex (APOBEC) family deaminase. In some embodiments, the deaminase is an APOBEC 1 family deaminase. In some embodiments, the deaminase is an activation-induced cytidine deaminase (AID). Some nucleic-acid editing domains as well as Cas9 fusion proteins including such domains are described in detail herein. Additional suitable effector domains will be apparent to the skilled artisan based on this disclosure. In some embodiments, the nucleid-acid editing domain is a Fokl nuclease domain.

[00154] The instant disclosure provides Cas9:effector domain fusion proteins of various configurations. In some embodiments, the effector domain is fused to the N-terminus of the Cas9 protein. In some embodiments, the effector domain is fused to the C-terminus of the Cas9 protein. In some embodiments, the Cas9 protein and the effector domain are fused via a linker. In some embodiments, the linker comprises (GGGGS)_n (SEQ ID NO: 5), (G)_n, (EAAAK)_n (SEQ ID NO: 6), (GGS)_n, orSGSETPGTSESATPES (SEQ ID NO: 7) motif (see, e.g., Guilinger JP, Thompson DB, Liu DR. Fusion of catalytically inactive Cas9 to Fokl nuclease improves the specificity of genome modification. Nat. Biotechnol. 2014; 32(6): 577- 82; the entire contents are incorporated herein by reference), or an (XP)_n motif, or a combination of any of these, wherein n is independently an integer between 1 and 30. In some embodiments, n is independently 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, or 30, or, if more than one linker or more than one linker motif is present, any combination thereof. Additional suitable linker motifs and linker configurations will be apparent to those of skill in the art. In some embodiments, suitable linker motifs and configurations include those described in Chen et al, Fusion protein linkers: property, design and functionality. Adv Drug Deliv Rev. 2013; 65(10): 1357- 69, the entire contents of which are incorporated herein by reference. Additional suitable linker sequences will be apparent to those of skill in the art based on the instant disclosure and knowledge in the art.

[00155] In some embodiments, the general architecture of exemplary Cas9 fusion proteins provided herein comprises the structure:

[NH₂]-[effector domain]-[Cas9]-[COOH] or

[ H₂]-[Cas9]-[effector domain] -[COOH],

wherein H₂ is the N-terminus of the fusion protein, and COOH is the C-terminus of the fusion protein. Figure 11 provides a schematic representation of a Cas9 protein fused to an effector domain {e.g., rAPOBECl) in complex with sgRNA and bound to the target nucleic acid sequence.

[00156] In some embodiments, any of the fusion proteins provided herein may comprise one or more nuclear localization sequence (NLS). As used herein, a nuclear localization sequence refers to an amino acid sequence that promotes importation of a protein, for example any of the fusion proteins provided herein having an NLS, into the cell nucleus {e.g., via nuclear transport). Typically, an NLS comprises one or more short amino acid sequences of positively charged lysines or arginines exposed on the protein surface. Nuclear localization seuqneces are known in the art and would be apparent to the skilled artisan. For example nuclear localization sequences have been described in Kalderon D., et al, "A short amino acid sequence able to specify nuclear location". Cell (1984) 39 (3 Pt 2): 499-509; Dingwall C, et al, "The nucleoplasmin nuclear location sequence is larger and more complex than that of SV-40 large T antigen". J Cell Biol. (1988) 107 (3): 841-9;

Makkerh LP., et al, "Comparative mutagenesis of nuclear localization signals reveals the importance of neutral and acidic amino acids". Curr Biol. (1996) 6 (8): 1025-7; and Ray M., et al., "Quantitative tracking of protein trafficking to the nucleus using cytosolic protein delivery by nanoparticle-stabilized nanocapsules". Bioconjug. Chem. (2015) 26 (6): 1004-7; the entire contents of each are incorporated by reference herein. Additional nuclear localization sequences are described, for example, in Plank et al, PCT/EP2000/011690, the entire contents are incorporated by reference herein. In some embodiments, a NLS comprises the amino acid sequence PKKKRKV (SEQ ID NO: 299) or

MDSLLMNRRKFLYQFKNVRWAKGRRETYLC (SEQ ID NO: 300).

[00157] Exemplary features that may be present are localization sequences, such as nuclear localization sequences, cytoplasmic localization sequences, export sequences, such as nuclear export sequences, or other localization sequences, as well as sequence tags that are useful for solubilization, purification, or detection of the fusion proteins. Suitable

localization signal sequences and sequences of protein tags are provided herein, and include, but are not limited to, biotin carboxylase carrier protein (BCCP) tags, myc-tags, calmodulin- tags, FLAG-tags, hemagglutinin (HA)-tags, polyhistidine tags, also referred to as histidine tags or His-tags, maltose binding protein (MBP)-tags, nus-tags, glutathione-S-transferase (GST)-tags, green fluorescent protein (GFP)-tags, thioredoxin-tags, S-tags, Softags {e.g., Softag 1, Softag 3), strep-tags , biotin ligase tags, FlAsH tags, V5 tags, and SBP-tags.

Additional suitable sequences will be apparent to those of skill in the art and are within the scope ofthis disclosure.

[00158] Any of the nuclear localization sequences provided herein may be fused to the fusion protein in any suitable localization. For example, to promote translocation of the fusion protein into a cell nucleus without compromising function of the fusion protein. In some embodiments, the NLS is fused N-terminal to the Cas9 protein of the fusion protein. In some embodiments, the NLS is fused C-terminal to the Cas9 protein of the fusion protein. In some embodiments, the NLS is fused N-terminal to the effector domain of the fusion protein. In some embodiments, the NLS is fused C-terminal to the effector domain of the fusion protein.

[00159] In some embodiments, the effector domain is a deaminase. For example, in some embodiments, the general architecture of exemplary Cas9 fusion proteins with a deaminase domain comprises the structure:

[NH₂]-[NLS]-[Cas9]-[deaminase]-[COOH],

[NH₂]-[NLS]-[deaminase]-[Cas9]-[COOH],

[NH₂]-[Cas9]-[NLS]-[deaminase]-[COOH],

[NH₂]-[deaminase]-[NLS]-[Cas9]-[COOH],

[NH₂]-[deaminase]-[Cas9]-[NLS]-[COOH], or [ H₂]-[Cas9]-[deaminase]-[ LS]-[COOH],

wherein NLS is a nuclear localization signal, NH₂ is the N-terminus of the fusion protein, and COOH is the C-terminus of the fusion protein. In some embodiments, a linker is inserted between the Cas9 protein and the deaminase domain. In some embodiments, any of the "]-[" may be one or more linkers. In some embodiments, the NLS is located C-terminal of the deaminase and/or the Cas9 domain. In some embodiments, the NLS is located between the deaminase and the Cas9 domain. Additional features, such as sequence tags, may also be present.

[00160] One exemplary suitable type of effector domain includes cytosine deaminases, for example, of the APOBEC family. The apolipoprotein B mRNA-editing complex

(APOBEC) family of cytosine deaminase enzymes encompasses eleven proteins that serve to initiate mutagenesis in a controlled and beneficial manner.²⁹ One family member, activation- induced cytidine deaminase (AID), is responsible for the maturation of antibodies by converting cytosines in ssDNA to uracils in a transcription-dependent, strand-biased fashion.³⁰ The apolipoprotein B editing complex 3 (APOBEC3) enzyme provides protection to human cells against a certain HIV-1 strain via the deamination of cytosines in reverse- transcribed viral ssDNA.³¹ These proteins all require a Zn²⁺-coordinating motif (His-X-Glu- X₂3-26-Pro-Cys-X_2-4-Cys; SEQ ID NO: 283) and bound water molecule for catalytic activity. The Glu residue acts to activate the water molecule to a zinc hydroxide for nucleophilic attack in the deamination reaction. Each family member preferentially deaminates at its own particular "hotspot," ranging from WRC (W is A or T, R is A or G) for hAID, to TTC for hAPOBEC3F.³² A recent crystal structure of the catalytic domain of APOBEC3G revealed a secondary structure comprised of a five-stranded β-sheet core flanked by six a-helices, which is believed to be conserved across the entire family.³³ The active center loops have been shown to be responsible for both ssDNA binding and in determining "hotspot" identity.³⁴ Overexpression of these enzymes has been linked to genomic instability and cancer, thus highlighting the importance of sequence-specific targeting.³⁵

[00161] Some aspects of this disclosure provide a systematic series of fusions between Cas9 and deaminase domains, e.g., cytosine deaminase enzymes such as APOBEC enzymes, or adenosine deaminase enzymes such as AD AT enzymes, that has been generated in order to direct the enzymatic activities of these deaminases to a specific site in genomic DNA. The advantages of using Cas9 as the recognition agent are two-fold: (1) the sequence specificity of Cas9 can be easily altered by simply changing the sgRNA sequence; and (2) Cas9 binds to its target sequence by denaturing the dsDNA, resulting in a stretch of DNA that is single- stranded and therefore a viable substrate for the deaminase. It will be understood that other catalytic domains, or catalytic domains from other deaminases, can also be used to generate fusion proteins with Cas9, and that the disclosure is not limited in this regard.

[00162] Some aspects of this disclosure are based on the recognition that

cas9: deaminase fusion proteins can efficiently deaminate nucleotides at positions 3-11 according to the numbering scheme in Figure 11. It should be appreciated that a person of skill in the art will be able to design suitable guide RNAs to target the fusion proteins to a target sequence that comprises a nucleotide to be deaminated. Both PAM-dependent Cas9 proteins or Cas9 proteins that can target PAM-less target sequences as provided herein, can be employed for deamination of a target nucleotide.

[00163] Some exemplary suitable nucleic-acid editing domains, e.g., deaminases and deaminase domains, that can be fused to Cas9 domains according to aspects of this disclosure are provided below. Typically, deaminase require a Zn²⁺-coordinating motif (His-X-Glu-X_{23- 26}-Pro-Cys-X_2-4-Cys; SEQ ID NO: 283) and bound water molecule for catalytic activity. The Glu residue acts to activate the water molecule to a zinc hydroxide for nucleophilic attack in the deamination reaction. It will be understood that, in some embodiments, the active domain of the respective sequence can be used, e.g., the domain without a localizing signal (nuclear localizing signal, without nuclear export signal, cytoplasmic localizing signal).

[00164] Human AID:

MDSLLMNRRKFLYQFKNWWAKGRRETYLCYVVKRRDSATSFSLDFGYLRNKNGC HVELLFLRYISDWDLDPGRCYRVTWFTSWSPCYDCARHVADFLRGNPNLSLRIFTAR LYFCEDRKAEPEGLRRLHRAGVQIAF TFKDYFYCWNTFVENHERTFKAWEGLHEN SVRLSROLRRILLPLYEVDDLRDAFRTLGL (SEQ ID NO: 263)

(underline: nuclear localization signal; double underline: nuclear export signal)

[00165] Mouse AID:

MDSLLMKQKKFLYHFKNVRWAKGRHETYLCYVVKRRDSATSCSLDFGHLRNKSGC HVELLFLRYISDWDLDPGRCYRVTWFTSWSPCYDCARHVAEFLRWNPNLSLRIFTAR LYFCEDRKAEPEGLRRLHRAGVQIGFMTFKDYFYCWNTFVENRERTFKAWEGLHEN SVRLTROLRRILLPLYEVDDLRDAFRMLGF (SEQ ID NO: 264)

(underline: nuclear localization signal; double underline: nuclear export signal)

[00166] Dog AID: MP SLLMKQRKFLYHFKNVRWAKGRHET YLC YVVKRRD S AT SF SLDFGHLRNKSGC HVELLFLRYISDWDLDPGRCYRVTWFTSWSPCYDCARHVADFLRGYPNLSLRIFAAR LYFCEDRKAEPEGLRRLHRAGVQIAF TFKDYFYCWNTFVE REKTFKAWEGLHEN SVRLSROLRRILLPLYEVDDLRDAFRTLGL (SEQ ID NO: 265)

(underline: nuclear localization signal; double underline: nuclear export signal)

[00167] Bovine AID:

MP SLLKKOROFLYOFKNVRWAKGRFIET YLC YVVKRRD SPT SF SLDFGHLRNK AGC HVELLFLRYISDWDLDPGRCYRVTWFTSWSPCYDCARHVADFLRGYPNLSLRIFTAR LYFCDKERKAEPEGLRRLHRAGVQIAFMTFKDYFYCWNTFVENHERTFKAWEGLHE NSVRLSROLRRILLPLYEVDDLRDAFRTLGL (SEQ ID NO: 266)

(underline: nuclear localization signal; double underline: nuclear export signal)

[00168] Mouse APOBEC-3 :

MGPFCLGCSHRKCYSPIRNLISQETFKFHFKNLGYAKGRKDTFLCYEVTRKDCDSPV SLHHG KNKD IH^^

ATHHNLSLDIF S SRLYNVQDPETQQNLCRLVQEGAQ VAAMDLYEFKKCWKKFVDN GGRRFRPWKRLLTNFRYQD SKLQEILRPC YIP VP S S S S S TL SNICLTKGLPETRF C VEG RRMDPLSEEEFYSQFYNQRVKHLCYYHRMKPYLCYQLEQFNGQAPLKGCLLSEKGK QHAEILFLDKIRSMELSQ VTITCYL TTFS C WCAWQL AAFKRDRPDLILHIYT SRL YFHW KRPFQKGLCSLWQSGILVDVMDLPQFTDCWTNFVNPKRPFWPWKGLEIISRRTQRRL RRIKESWGLQDLVNDFGNLQLGPPMS (SEQ ID NO: 267)

(italic: nucleic acid editing domain)

[00169] Rat APOBEC-3 :

MGPFCLGCSHRKCYSPIRNLISQETFKFHFKNLRYAIDRKDTFLCYEVTRKDCDSPVS LHHGVFKNKD IH^^

THHNLSLDIF S SRL YNIRDPENQQNLCRL VQEGAQ VAAMDL YEFKKCWKKF VDNGG RRFRPWKKLLTNFRYQD SKLQEILRPC YIP VP S S S S STLSNICLTKGLPETRFC VERRR VHLLSEEEFYSQFYNQRVKHLCYYHGVKPYLCYQLEQFNGQAPLKGCLLSEKGKQH AEILFLDnRSMELSQVIITCYL SPCPNC AW QLAAFKRD ^O JLmYT m_^YFi KR PFQKGLCSLWQSGILVDVMDLPQFTDCWTNFVNPKRPFWPWKGLEIISRRTQRRLHR

n ESWGLQDLVNDFGNLQLGPPMS (SEQ ID NO: 268)

(italic: nucleic acid editing domain) [00170] Rhesus macaque APOBEC-3G:

MVEPMDPRTFVS FNK PILSGLNTVWLCCEVKTKDPSGPPLDAKIFQGKVYSKAKY

HPEMRFLRWFHKWROLHHDOEYKVTWYVSWSPCTRCANSyAT^ AKmKYT TJFyA

RLYYFWKPDYQQALRILCQKRGGPHATMKIMNYNEFQDCW KFVDGRGKPFKPRN LPKHYTLLQATLGELLRHLMDPGTFTS FN KPWVSGQHETYLCYKVERLHNDT

WVPL^QHKG^LR^QAP^JRGWKGRHAELCFLDLIPFWKLDGQQYRVTCFTSWSPCFS

CAQEMAKFISNNEHVSLCIFAARIYDDQGRYQEGLRALHRDGAKIAMMNYSEFEYC

WDTFVDRQGRPFQPWDGLDEHSQALSGRLRAI (SEQ ID NO: 269)

(italic: nucleic acid editing domain; underline: cytoplasmic localization signal)

[00171] Chimpanzee APOBEC-3G:

MKPHFRNPVERMYQDTFSDNFYNRPILSHRNTVWLCYEVKTKGPSRPPLDAKIFRGQ YYSK KYHPEMPJ^FHWFSKWRKLHmOEYEVT iSWSPCTKCTm)yAT¥ AEmKy TLTIFVARLYYFWDPDYQEALRSLCQKRDGPRATMKF NYDEFQHCWSKFVYSQRE LFEPWNNLPKYYILLHIMLGEILRHSMDPPTFTSNFNNELWVRGRHETYLCYEVERL HNDTW VLLNQRRGFLCNQ APHKHGFLEGRH^ELC JZ) VIPFWKLDLHQDYR VTCFTS f ^PC ^CAQEMAKFISNNKHVSLCIFAARIYDDQGRCQEGLRTLAKAGAKISF TYSE FKHCWDTFVDHQGCPFQPWDGLEEHSQALSGRLRAILQNQGN (SEQ ID NO: 270) (italic: nucleic acid editing domain; underline: cytoplasmic localization signal)

[00172] Green monkey APOBEC-3G:

MNPQIRNMVEQMEPDIFVYYFNNRPILSGRNTVWLCYEVKTKDPSGPPLDANIFQGK YFEAKOHPEMKFLHWFRKWROLHRDOEYEVTWYVSWSPCTRCANSYAT^ AEmKy

TLTIFVARLYYFWKPDYQQALRILCQERGGPHATMKFMNYNEFQHCWNEFVDGQG

KPFKPRKNLPKHYTLLHATLGELLRHVMDPGTFTSNFNNKPWVSGQRETYLCYKVE

RSHNDTWVLLNQimGFLRNQAPDRHGFPKGRH^EJC J^^

^fKSPC ^CAQKMAKFISNNKHVSLCIFAARIYDDQGRCQEGLRTLHRDGAKIAVMNY SEFEYCWDTFVDRQGRPFQPWDGLDEHSQALSGRLRAI (SEQ ID NO: 271)

(italic: nucleic acid editing domain; underline: cytoplasmic localization signal)

[00173] Human APOBEC-3G:

MKPHFRNTVERMYRDTFSYNFYNRPILSRRNTVWLCYEVKTKGPSRPPLDAKIFRGO

YYSE KYHPEMPJ^FHWFSKWRKLHmOEYEVTWYISWSPCTKCTRDMATE AEmKy TLTIFVARLYYFWDPDYQEALRSLCQKRDGPRATMKIMNYDEFQHCWSKFVYSQRE LFEPWNNLPKYYILLHIMLGEILRHSMDPPTFTFNFNNEPWVRGRHETYLCYEVERM IINDTW VLLNQRRGFLCNQ APHKHGFLEGRH^£JC JL> VIPFWKLDLDQDYR VTCFTS ^PC ^CAQEMAKFISK KHVSLCIFTARIYDDQGRCQEGLRTLAEAGAKISF TYSE FKHCWDTFVDHQGCPFQPWDGLDEHSQDLSGRLRAILQNQEN (SEQ ID NO: 272) (italic: nucleic acid editing domain; underline: cytoplasmic localization signal)

[00174] Human APOBEC-3F:

MKPHFRNTVERMYRDTFSYNFYNRPILSRRNTVWLCYEVKTKGPSRPRLDAKIFRGQ

YYSQmmiAEMCFLSWFCGNQLPAYKCFQITWFVSWTPCPDCyAKLAEF AE P^yT

TISAARLYYYWERDYRRALCRLSQAGARVKF DDEEFAYCWENFVYSEGQPFMPW

YKFDDNYAFLHRTLKEILRNPMEAMYPHIFYFHFKNLRKAYGRNESWLCFTMEVVK

IIHSPVSWKRG RNQVDPETHCH^/iRC J_^W C/J^

GEVAEFLARHSNVNLTIFTARLYYFWDTDYQEGLRSLSQEGASVEF GYKDFKYCW ENF V YNDDEPFKP WKGLK YNFLFLD SKLQEILE (SEQ ID NO: 273)

(italic: nucleic acid editing domain)

[00175] Human APOBEC-3B:

MNPQIRNPMERMYRDTFYDNFENEPILYGRSYTWLCYEVKIKRGRSNLLWDTGVFR

GQYY^K^QYHAEMCFLSWFCGNQLPAYKCFQITWFVSWTPCPDCYAKLAEF SE P^ VTLTISAARLYYYWERDYRRALCRLSQAGARVTFMDYEEFAYCWENFVYNEGQQF MPWYKFDENYAFLHRTLKEILRYLMDPDTFTFNFNNDPLVLRRRQTYLCYEVERLD NGTWVLMDQHMGFLCNEAKNLLCGFYGi^EJi^J^^

C ^f GCAGEVRAFLQENTHVRLRIFAARIYDYDPLYKEALQMLRDAGAQVSF TY DEFEYCWDTFVYRQGCPFQPWDGLEEHSQALSGRLRAILQNQGN (SEQ ID NO: 274) (italic: nucleic acid editing domain)

[00176] Human APOBEC-3C:

MNPQIRNPMKAMYPGTFYFQFKNLWEANDRNETWLCFTVEGIKRRSVVSWKTGVF RNQ VD SETHCHAERCFLSWFCDDILSPNTKYQ VTWYTSWSPCPDCAGEV AEF ARHSN VNLTIF T ARL Y YF Q YPC YQEGLRSL S QEGV A VEF D YEDFK YC WENF V YNDNEPFKP WKGLKTNFRLLKRRLRESLQ (SEQ ID NO: 275)

(italic: nucleic acid editing domain) [00177] Human APOBEC-3A:

MEASPASGPRHLMDPHIFTSNFNNGIGRHKTYLCYEVERLDNGTSVKMDQHRGFLH

^QAKWA_^CG^YGRHAELRFLDLVPSLQLDPAQIYRVTWFISWSPCFSWGCAGEVRAF Q ENTHVRLRIFAARIYDYDPLYKEALQMLRDAGAQVSF TYDEFKHCWDTFVDHQGC PFQPWDGLDEHSQALSGRLRAILQNQGN (SEQ ID NO: 276)

(italic: nucleic acid editing domain)

[00178] Human APOBEC-3H:

MALLTAETFRLQFNNKRRLRRPYYPRKALLCYQLTPQNGSTPTRGWE KKKC/il/i/ CFINEIKSMGLDETQCYQVTCYL SPCSSC AWE VD^JKAHDm^ GJFA RLYYHWC KPQQKGLRLLCGSQVPVEVMGFPKFADCWE FVDHEKPLSF PYKMLEELDKNSRA IKRRLERIKIPGVRAQGRYMDILCDAEV (SEQ ID NO: 277)

(italic: nucleic acid editing domain)

[00179] Human APOBEC-3D:

MNPQIRNPMERMYRDTFYDNFENEPILYGRSYTWLCYEVKIKRGRSNLLWDTGVFR

KVTKFLAEHPNVTLTISAARLYYYRDRDWRWVLLRLHKAGARVKIMDYEDFAYCW ENFVCNEGQPFMPWYKFDDNYASLHRTLKEILRNPMEAMYPHIFYFHFKNLLKACG RNESWLCFTMEVTKHHSA RKRGVFRNQVDPEra

EFr^re^C ECAGEVAEFLARHSNVNLTIFTARLCYFWDTDYQEGLCSLSQEGAS VKF GYKDFVSCWKNFVYSDDEPFKPWKGLQTNFRLLKRRLREILQ (SEQ ID NO: 278)

(italic: nucleic acid editing domain) [00180] Human APOBEC-1 :

MTSEKGPSTGDPTLRRRIEPWEFDVFYDPRELRKEACLLYEIKWGMSRKIWRSSGKN TTNHVEVNFIKKF T SERDFHP SMS C SITWFL S W SPC WEC S Q AIREFL SRHPGVTL VI Y V ARLFWHMDQQNRQGLRDLVNSGVTIQF RASEYYHCWRNFVNYPPGDEAHWPQY PPLWMMLYALELHCIILSLPPCLKISRRWQNHLTFFRLHLQNCHYQTIPPHILLATGLI HPSVAWR (SEQ ID NO: 279) [00181] Mouse APOBEC-1 :

MSSETGPVAVDPTLRRRIEPHEFEVFFDPRELRKETCLLYEINWGGRHSVWRHTSQN TS HVEVNFLEKFTTERYFRPNTRCSITWFLSWSPCGECSRAITEFLSRHPYVTLFIYIA RLYHHTDQR RQGLRDLISSGVTIQF TEQEYCYCWR FVNYPPS EAYWPRYPHL WVKLYVLELYCIILGLPPCLKILRRKQPQLTFFTITLQTCHYQRIPPHLLWATGLK

(SEQ ID NO: 280)

[00182] Rat APOBEC-1 :

MSSETGPVAVDPTLRRRIEPHEFEVFFDPRELRKETCLLYEINWGGRHSIWRHTSQNT KHVEVNFIEKFTTERYFCPNTRCSITWFLSWSPCGECSRAITEFLSRYPHVTLFIYIAR LYHHADPRNRQGLRDLISSGVTIQIMTEQESGYCWRNFVNYSPSNEAHWPRYPHLW VRLYVLELYCIILGLPPCLNILRRKQPQLTFFTIALQSCHYQRLPPHILWATGLK (SEQ ID NO: 281)

[00183] In some embodiments, fusion proteins as provided herein comprise the full- length amino acid of a effector domain, e.g., one of the sequences provided above. In other embodiments, however, fusion proteins as provided herein do not comprise a full-length sequence of a effector domain, but only a fragment thereof. For example, in some embodiments, a fusion protein provided herein comprises a Cas9 protein and a fragment of a effector domain, e.g., wherein the fragment comprises a effector domain. Exemplary amino acid sequences of effector domains are shown in the sequences above as italicized letters, and additional suitable sequences of such domains will be apparent to those of skill in the art.

[00184] Additional suitable nucleic-acid editing domain, e.g., deaminase domain sequences, that can be used according to aspects of this disclosure, e.g., that can be fused to a nuclease-inactive Cas9 protein, will be apparent to those of skill in the art based on this disclosure. In some embodiments, such additional domain sequences include deaminase domain sequences that are at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% similar to the sequences provided herein. Additional suitable Cas9 proteins, variants, and sequences will also be apparent to those of skill in the art. Examples of such additional suitable Cas9 proteins include, but are not limited to Cas9 proteins with the following mutations: D10A,

D10A/D839A/H840A, and D10A/D839A/H840A/N863A (See, e.g., Prashant et al, CAS9 transcriptional activators for target specificity screening and paired nickases for cooperative genome engineering. Nature Biotechnology. 2013; 31(9): 833-838 the entire contents of which are incorporated herein by reference).

[00185] Additional suitable strategies for generating fusion proteins comprising a Cas9 protein and an effector domain, such as a DNA-editing domain, will be apparent to those of skill in the art based on this disclosure in combination with the general knowledge in the art. Suitable strategies for generating fusion proteins according to aspects of this disclosure using linkers or without the use of linkers will also be apparent to those of skill in the art in view of the instant disclosure and the knowledge in the art. For example, Gilbert et al, CRISPR- mediated modular RNA-guided regulation of transcription in eukaryotes. Cell. 2013;

154(2):442-51, showed that C-terminal fusions of Cas9 with VP64 using 2 NLS's as a linker (SPKKKRKVEAS, SEQ ID NO: 284), can be employed for transcriptional activation. Mali et al, Cas9 transcriptional activators for target specificity screening and paired nickases for cooperative genome engineering. Nat Biotechnol. 2013; 31(9): 833-8, reported that C-terminal fusions with VP64 without linker can be employed for transcriptional activation. And Maeder et al, CRISPR RNA-guided activation of endogenous human genes. Nat Methods. 2013; 10: 977-979, reported that C-terminal fusions with VP64 using a Gly₄Ser (SEQ ID NO: 5) linker can be used as transcriptional activators. Recently, dCas9- Fokl nuclease fusions have successfully been generated and exhibit improved enzymatic specificity as compared to the parental Cas9 enzyme (In Guilinger JP, Thompson DB, Liu DR. Fusion of catalytically inactive Cas9 to Fokl nuclease improves the specificity of genome modification. Nat.

Biotechnol. 2014; 32(6):577-82, and in Tsai SQ, Wyvekens N, Khayter C, Foden JA, Thapar V, Reyon D, Goodwin MJ, Aryee MJ, Joung JK. Dimeric CRISPR RNA-guided Fokl nucleases for highly specific genome editing. Nat. Biotechnol. 2014; 32(6):569-76. PMTD: 24770325 a SGSETPGTSESATPES (SEQ ID NO: 7) or a GGGGS (SEQ ID NO: 5) linker was used in FokI-dCas9 fusion proteins, respectively).

[00186] In some embodiments, the Cas9 fusion protein comprises: (i) Cas9 protein; and (ii) a transcriptional activator domain. In some embodiments, the transcriptional activator domain comprises a VPR. VPR is a VP64-SV40-P65-RTA tripartite activator. In some embodiments, VPR compises a VP64 amino acid sequence encoded by the nucleic acid sequence of SEQ ID NO: 292:

GAGGCCAGCGGTTCCGGACGGGCTGACGCATTGGACGATTTTGATCTGGATATGC TGGGAAGTGACGCCCTCGATGATTTTGACCTTGACATGCTTGGTTCGGATGCCCT TGATGACTTTGACCTCGACATGCTCGGCAGTGACGCCCTTGATGATTTCGACCTG GACATGCTGATTAACTCTAGATAG (SEQ ID NO: 292) [00187] In some embodiments, VPR comprises a VP64 amino acid sequence as set forth in SEQ ID NO: 293 :

EASGSGRADALDDFDLDMLGSDALDDFDLDMLGSDALDDFDLDMLGSDALDDFDL DMLINSR (SEQ ID NO: 293)

[00188] In some embodiments, VPR compises a VP64-SV40-P65-RTA amino acid sequence encoded by the nucleic acid sequence of SEQ ID NO: 294:

TCGCCAGGGATCCGTCGACTTGACGCGTTGATATCAACAAGTTTGTACAAAAAAG

CAGGCTACAAAGAGGCCAGCGGTTCCGGACGGGCTGACGCATTGGACGATTTTG

ATCTGGATATGCTGGGAAGTGACGCCCTCGATGATTTTGACCTTGACATGCTTGG

TTCGGATGCCCTTGATGACTTTGACCTCGACATGCTCGGCAGTGACGCCCTTGAT

GATTTCGACCTGGACATGCTGATTAACTCTAGAAGTTCCGGATCTCCGAAAAAGA

AACGCAAAGTTGGTAGCCAGTACCTGCCCGACACCGACGACCGGCACCGGATCG

AGGAAAAGCGGAAGCGGACCTACGAGACATTCAAGAGCATCATGAAGAAGTCC

CCCTTCAGCGGCCCCACCGACCCTAGACCTCCACCTAGAAGAATCGCCGTGCCCA

GCAGATCCAGCGCCAGCGTGCCAAAACCTGCCCCCCAGCCTTACCCCTTCACCAG

CAGCCTGAGCACCATCAACTACGACGAGTTCCCTACCATGGTGTTCCCCAGCGGC

CAGATCTCTCAGGCCTCTGCTCTGGCTCCAGCCCCTCCTCAGGTGCTGCCTCAGG

CTCCTGCTCCTGCACCAGCTCCAGCCATGGTGTCTGCACTGGCTCAGGCACCAGC

ACCCGTGCCTGTGCTGGCTCCTGGACCTCCACAGGCTGTGGCTCCACCAGCCCCT

AAACCTACACAGGCCGGCGAGGGCACACTGTCTGAAGCTCTGCTGCAGCTGCAG

TTCGACGACGAGGATCTGGGAGCCCTGCTGGGAAACAGCACCGATCCTGCCGTG

TTCACCGACCTGGCCAGCGTGGACAACAGCGAGTTCCAGCAGCTGCTGAACCAG

GGCATCCCTGTGGCCCCTCACACCACCGAGCCCATGCTGATGGAATACCCCGAG

GCCATCACCCGGCTCGTGACAGGCGCTCAGAGGCCTCCTGATCCAGCTCCTGCCC

CTCTGGGAGCACCAGGCCTGCCTAATGGACTGCTGTCTGGCGACGAGGACTTCAG

CTCTATCGCCGATATGGATTTCTCAGCCTTGCTGGGCTCTGGCAGCGGCAGCCGG

GATTCCAGGGAAGGGATGTTTTTGCCGAAGCCTGAGGCCGGCTCCGCTATTAGTG

ACGTGTTTGAGGGCCGCGAGGTGTGCCAGCCAAAACGAATCCGGCCATTTCATCC

TCCAGGAAGTCCATGGGCCAACCGCCCACTCCCCGCCAGCCTCGCACCAACACC

AACCGGTCCAGTACATGAGCCAGTCGGGTCACTGACCCCGGCACCAGTCCCTCA

GCCACTGGATCCAGCGCCCGCAGTGACTCCCGAGGCCAGTCACCTGTTGGAGGA

TCCCGATGAAGAGACGAGCCAGGCTGTCAAAGCCCTTCGGGAGATGGCCGATAC

TGTGATTCCCCAGAAGGAAGAGGCTGCAATCTGTGGCCAAATGGACCTTTCCCAT

CCGCCCCCAAGGGGCCATCTGGATGAGCTGACAACCACACTTGAGTCCATGACC GAGGATCTGAACCTGGACTCACCCCTGACCCCGGAATTGAACGAGATTCTGGAT ACCTTCCTGAACGACGAGTGCCTCTTGCATGCCATGCATATCAGCACAGGACTGT CCATCTTCGACACATCTCTGTTTTGA (SEQ ID NO: 294)

[00189] In some embodiments, VPR comprises a VP64-SV40-P65-RTA amino acid sequence as set forth in SEQ ID NO: 295:

SPGIRRLDALISTSLYKKAGYKEASGSGRADALDDFDLDMLGSDALDDFDLDMLGS DALDDFDLDMLGSDALDDFDLDMLINSRSSGSPKKKRKVGSQYLPDTDDRHRIEEK RKRTYETFKSFMKKSPFSGPTDPRPPPRRIAVPSRSSASVPKPAPQPYPFTSSLSTINYD EFPTMVFPSGQISQASALAPAPPQVLPQAPAPAPAPAMVSALAQAPAPVPVLAPGPPQ AVAPPAPKPTQAGEGTLSEALLQLQFDDEDLGALLGNSTDPAVFTDLASVDNSEFQQ LLNQGIPVAPHTTEPMLMEYPEAITRLVTGAQRPPDPAPAPLGAPGLPNGLLSGDEDF SSIADMDFSALLGSGSGSRDSREGMFLPKPEAGSAISDVFEGREVCQPKRIRPFHPPGS PWANRPLPASLAPTPTGPVHEPVGSLTPAPVPQPLDPAPAVTPEASHLLEDPDEETSQ AVKALREMADTVIPQKEEAAICGQMDLSHPPPRGHLDELTTTLESMTEDLNLDSPLT PELNEILDTFLNDECLLHAMHISTGLSIFDTSLF (SEQ ID NO: 295)

[00190] Some aspects of this disclosure provide fusion proteins comprising a transcription activator. In some embodiments, the transcriptional activator is VPR. In some embodiments, the VPR compsises a wild type VPR or a VPR as set forth in SEQ ID NO: 293. In some embodiments, the VPR proteins provided herein include fragments of VPR and proteins homologous to a VPR or a VPR fragment. For example, in some embodiments, a VPR comprises a fragment of the amino acid sequence set forth in SEQ ID NO: 293. In some embodiments, a VPR comprises an amino acid sequence homologous to the amino acid sequence set forth in SEQ ID NO: 293 or an amino acid sequence homologous to a fragment of the amino acid sequence set forth in SEQ ID NO: 293. In some embodiments, proteins comprising VPR or fragments of VPR or homologs of VPR or VPR fragments are referred to as "VPR variants." A VPR variant shares homology to VPR, or a fragment thereof. For example a VPR variant is at least about 70% identical, at least about 80% identical, at least about 90%) identical, at least about 95% identical, at least about 96% identical, at least about 97%) identical, at least about 98%> identical, at least about 99% identical, at least about 99.5% identical, or at least about 99.9% to a wild type VPR or a VPR as set forth in SEQ ID NO: 293. In some embodiments, the VPR variant comprises a fragment of VPR, such that the fragment is at least about 70% identical, at least about 80% identical, at least about 90% identical, at least about 95% identical, at least about 96% identical, at least about 97% identical, at least about 98% identical, at least about 99% identical, at least about 99.5% identical, or at least about 99.9% to the corresponding fragment of wild type VPR or a VPR as set forth in SEQ ID NO: 293. In some embodiments, the VPR comprises the amino acid sequence set forth in SEQ ID NO: 293. In some embodiments, the VPR comprises an amino acid sequence encoded by the nucleotide sequence set forth in SEQ ID NO: 292.

[00191] In some embodiments, a VPR is a VP64-SV40-P65-RTA triple activator. In some embodiments, the VP64-SV40-P65-RTA comprises a VP64-SV40-P65-RTA as set forth in SEQ ID NO: 295. In some embodiments, the VP64-SV40-P65-RTA proteins provided herein include fragments of VP64-SV40-P65-RTA and proteins homologous to a VP64-SV40-P65-RTA or a VP64-SV40-P65-RTA fragment. For example, in some embodiments, a VP64-SV40-P65-RTA comprises a fragment of the amino acid sequence set forth in SEQ ID NO: 295. In some embodiments, a VP64-SV40-P65-RTA comprises an amino acid sequence homologous to the amino acid sequence set forth in SEQ ID NO: 295 or an amino acid sequence homologous to a fragment of the amino acid sequence set forth in SEQ ID NO: 295. In some embodiments, proteins comprising VP64-SV40-P65-RTA or fragments of VP64-SV40-P65-RTA or homologs of VP64-SV40-P65-RTA or VP64-SV40- P65-RTA fragments are referred to as "VP64-SV40-P65-RTA variants." A VP64-SV40-P65- RTA variant shares homology to VP64-SV40-P65-RTA, or a fragment thereof. For example a VP64-SV40-P65-RTA variant is at least about 70% identical, at least about 80% identical, at least about 90% identical, at least about 95% identical, at least about 96% identical, at least about 97%) identical, at least about 98% identical, at least about 99% identical, at least about 99.5% identical, or at least about 99.9% to a VP64-SV40-P65-RTA as set forth in SEQ ID NO: 295. In some embodiments, the VP64-SV40-P65-RTA variant comprises a fragment of VP64-SV40-P65-RTA, such that the fragment is at least about 70% identical, at least about 80%) identical, at least about 90% identical, at least about 95% identical, at least about 96% identical, at least about 97% identical, at least about 98% identical, at least about 99% identical, at least about 99.5% identical, or at least about 99.9% to the corresponding fragment of a VP64-SV40-P65-RTA as set forth in SEQ ID NO: 295. In some embodiments, the VP64-SV40-P65-RTA comprises the amino acid sequence set forth in SEQ ID NO: 295. In some embodiments, the VP64-SV40-P65-RTA comprises an amino acid sequence encoded by the nucleotide sequence set forth in SEQ ID NO: 294.

[00192] Some aspects of this disclosure provide fusion proteins comprising (i) a Cas9 protein; and (ii) a effector domain. In some aspects, the fusion proteins provided herein further include (iii) a DNA-binding protein, for example, a zinc-finger domain, a TALE, or a second Cas9 protein. Without wishing to be bound by any particular theory, fusing a DNA- binding protein (e.g., a second Cas9 protein) to a fusion protein comprising (i) a protein; and (ii) a effector domain may be useful for improving specificity of the fusion protein to a target nucleic acid sequence, or for improving specificity or binding affinity of the fusion protein to bind a target nucleic acid sequence that does not contain the canonical PAM (5'-NGG-3 ') sequence. In some embodiments, the second Cas9 protein is any of the Cas9 proteins provided herein. In some embodiments, the second Cas9 protein is fused to the fusion protein N-terminal to the Cas9 protein. In some embodiments, the second Cas9 protein is fused to the fusion protein C-terminal to the Cas9 protein. In some embodiments, the Cas9 proteinand the second Cas9 protein are fused via a linker.

[00193] Further provided herein are complexes comprising any of the fusion proteins provided herein, a first guide RNA bound to the Cas9 protein of the fusion protein, and a second guide RNA bound to the second Cas9 protein of the fusion protein. In some embodiments, the first guide RNA is about 15-100 nucleotides long and comprises a sequence of at least 10 contiguous nucleotides that is complementary to a first target sequence and the second guide RNA is about 15-100 nucleotides long and comprises a sequence of at least 10 contiguous nucleotides that is complementary to a second target sequence. In some embodiments, the first guide RNA and/or the second guide RNA is 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, or 50 nucleotides long. In some embodiments, the first guide RNA and the second guide RNA are different. In some embodiments, the first guide RNA comprises a sequence of 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, or 40 contiguous nucleotides that is complementary to a first target sequence, and wherein the second guide RNA comprises a sequence of 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, or 40 contiguous nucleotides that is complementary to a second target sequence. In some embodiments, the first target sequence and the second target sequence are different. In some embodiments, the first target sequence and the second target sequence are DNA sequences. In some

embodiments, the first target sequence and the second target sequence are in the genome of a mammal. In some embodiments, the first target sequence and the second target sequence are in the genome of a human. In some embodiments, the first target sequence is within 30 nucleotides of the second target sequence. In some embodiments, the 3' end of the first target sequence is not immediately adjacent to the canonical PAM sequence (5 '-NGG-3 '). In some embodiments, the 3' end of the second target sequence is not immediately adjacent to the canonical PAM sequence (5'-NGG-3 '). [00194] In some embodiments, the general architecture of exemplary Cas9 fusion proteins provided herein is of the structure:

[ H₂]-[effector domain]-[Cas9]-[second Cas9 protein]-[COOH];

[ H₂]-[second Cas9 protein]-[Cas9]-[effector domain]-[COOH];

[ H₂]-[Cas9]-[effector domain]-[second Cas9 protein]-[COOH];

[ H₂]-[second Cas9 protein]-[effector or domain] -[Cas9] -[COOH];

[ H₂]-[UGI]-[effector domain]-[Cas9]-[second Cas9 protein]-[COOH];

[ H₂]-[UGI]-[second Cas9 protein] -[Cas9]- [effector domain]-[COOH];

[ H₂]-[UGI]-[Cas9]-[effector domain]-[second Cas9 protein]-[COOH];

[ H₂]-[UGI]-[second Cas9 protein] -[effector domain]-[Cas9]-[COOH];

[ H₂]-[effector domain]-[Cas9]-[second Cas9 protein]-[UGI]-[COOH];

[ H₂]-[second Cas9 protein]-[Cas9]-[effector domain]-[UGI]-[COOH];

[ H₂]-[Cas9]-[effector domain]-[second Cas9 protein]-[UGI]-[COOH]; or

[ H₂]-[second Cas9 protein]-[effector domain]-[Cas9]-[UGI]-[COOH];

wherein H₂ is the N-terminus of the fusion protein, and COOH is the C-terminus of the fusion protein. In some embodiments, the "]-[" used in the general architecture above indicates the presence of an optional linker sequence. In other examples, the general architecture of exemplary Cas9 fusion proteins provided herein is of the structure:

[NH₂]-[effector domain]-[Cas9]-[second Cas9 protein]-[COOH];

[NH₂]-[second Cas9 protein]-[Cas9]-[effector domain]-[COOH];

[NH₂]-[Cas9]-[effector domain]-[second Cas9 protein]-[COOH];

[NH₂]-[second Cas9 protein]-[effector domain]-[Cas9]-[COOH];

[NH₂]-[UGI]-[effector domain]-[Cas9]-[second Cas9 protein]-[COOH],

[NH₂]-[UGI]-[second Cas9 protein] -[Cas9]- [effector domain]-[COOH];

[NH₂]-[UGI]-[Cas9]-[effector domain]-[second Cas9 protein]-[COOH];

[NH₂]-[UGI]-[second Cas9 protein] -[effector domain]-[Cas9]-[COOH];

[NH₂]-[effector domain]-[Cas9]-[second Cas9 protein]-[UGI]-[COOH];

[NH₂]-[second Cas9 protein]-[Cas9]-[effector domain]-[UGI]-[COOH];

[NH₂]-[Cas9]-[effector domain]-[second Cas9 protein]-[UGI]-[COOH]; or

[NH₂]-[second Cas9 protein]-[effector domain]-[Cas9]-[UGI]-[COOH];

wherein NH₂ is the N-terminus of the fusion protein, and COOH is the C-terminus of the fusion protein. In some embodiments, the "-" used in the general architecture above indicates the presence of an optional linker sequence. In some embodiments, the second Cas9 is a dCas9 protein. In some examples, the general architecture of exemplary Cas9 fusion proteins provided herein comprises a structure as shown in Figure 8. It should be appreciated that any of the proteins provided in any of the general architectures of exemplary Cas9 fusion proteins may be connected by one or more of the linkers provided herein. In some embodiments, the linkers are the same. In some embodiments, the linkers are different. In some embodiments, one or more of the proteins provided in any of the general architectures of exemplary Cas9 fusion proteins are not fused via a linker. In some embodiments, the fusion proteins further comprise a nuclear targeting sequence, for example a nuclear localization sequence. In some embodiments, fusion proteins provided herein further comprise a nuclear localization sequence (NLS). In some embodiments, the NLS is fused to the N-terminus of the fusion protein. In some embodiments, the NLS is fused to the C-terminus of the fusion protein. In some embodiments, the NLS is fused to the N-terminus of the second Cas9 protein. In some embodiments, the NLS is fused to the C-terminus of the second Cas9 protein. In some embodiments, the NLS is fused to the N-terminus of the Cas9 protein. In some embodiments, the NLS is fused to the C-terminus of the Cas9 protein. In some embodiments, the NLS is fused to the N-terminus of the effector domain. In some embodiments, the NLS is fused to the C-terminus of the effector domain. In some embodiments, the NLS is fused to the N- terminus of the UGI protein. In some embodiments, the NLS is fused to the C-terminus of the UGI protein. In some embodiments, the NLS is fused to the fusion protein via one or more linkers. In some embodiments, the NLS is fused to the fusioin protein without a linker.

Uracil glycosylase inhibitor fusion proteins

[00195] Some aspects of this disclosure provide fusion proteins comprising a Cas9 protein fused to a effector domain, e.g., a deaminase, and a uracil glycosylase inhibitor (UGI). In some embodiments, the fusion protein comprises the structure:

[deaminase]-[optional linker sequence]-[Cas9]-[optional linker sequence] -[UGI];

[deaminase]-[optional linker sequence]-[UGI]-[optional linker sequence]-[Cas9];

[UGI]-[optional linker sequence]-[deaminase]-[optional linker sequence]-[Cas9];

[UGI]-[optional linker sequence]-[Cas9]-[optional linker sequence]-[deaminase];

[Cas9]-[optional linker sequence]-[deaminase]-[optional linker sequence]-[UGI]; or

[Cas9]-[optional linker sequence]-[UGI]-[optional linker sequence]-[deaminase]. In some embodiments, the fusion proteins do not comprise a linker sequence. In some embodiments, one or both of the optional linker sequences are present. [00196] In some embodiments, the fusion protein further comprises a second Cas9 protein. For example, the second Cas9 protein may be any of the Cas9 proteins provided herein. In some embodiments, fusion protein comprises the structure:

[deaminase]-[Cas9]-[UGI]; [deaminase]-[UGI]-[Cas9];

[UGI]-[deaminase]-[Cas9];

[UGI]-[Cas9]-[deaminase];

[Cas9]-[deaminase]-[UGI];

[Cas9]-[UGI]-[deaminase];

[second Cas9]-[deaminase]-[Cas9]-[UGI];

[second Cas9]-[deaminase]-[UGI]-[Cas9];

[second Cas9]-[UGI]-[deaminase]-[Cas9];

[second Cas9]-[UGI]-[Cas9]-[deaminase];

[second Cas9]-[Cas9]-[deaminase]-[UGI];

[second Cas9]-[Cas9]-[UGI]-[deaminase];

[deaminase]-[second Cas9]-[Cas9]-[UGI];

[deaminase]-[second Cas9]-[UGI]-[Cas9];

[UGI]-[second Cas9]-[deaminase]-[Cas9];

[UGI]-[second Cas9]-[Cas9]-[deaminase];

[Cas9]-[second Cas9]-[deaminase]-[UGI];

[Cas9]-[second Cas9]-[UGI]-[deaminase]

[deaminase]-[Cas9]-[second Cas9]-[UGI];

[deaminase]-[UGI]-[second Cas9]-[Cas9];

[UGI]-[deaminase]-[second Cas9]-[Cas9];

[UGI]-[Cas9]-[second Cas9]-[deaminase];

[Cas9]-[deaminase]-[second Cas9]-[UGI];

[Cas9]-[UGI]-[second Cas9]-[deaminase];

[deaminase]-[Cas9]-[UGI]-[second Cas9];

[deaminase]-[UGI]-[Cas9]-[second Cas9];

[UGI]-[deaminase]-[Cas9]-[second Cas9];

[UGI]-[Cas9]-[deaminase]-[second Cas9];

[Cas9]-[deaminase]-[UGI]-[second Cas9]; or

[Cas9]-[UGI]-[deaminase]-[second Cas9].

In some embodiments, the "-" used in the general architecture above indicates the presence of an optional linker sequence. In some embodiments, the fusion proteins comprising a UGI further comprise a nuclear targeting sequence, for example a nuclear localization sequence. In some embodiments, fusion proteins provided herein further comprise a nuclear localization sequence (NLS). In some embodiments, the NLS is fused to the N-terminus of the fusion protein. In some embodiments, the NLS is fused to the C-terminus of the fusion protein. In some embodiments, the NLS is fused to the N-terminus of the UGI protein. In some embodiments, the NLS is fused to the C-terminus of the UGI protein. In some embodiments, the NLS is fused to the N-terminus of the Cas9 protein. In some embodiments, the NLS is fused to the C-terminus of the Cas9 protein. In some embodiments, the NLS is fused to the N-terminus of the deaminase. In some embodiments, the NLS is fused to the C-terminus of the deaminase. In some embodiments, the NLS is fused to the N-terminus of the second Cas9. In some embodiments, the NLS is fused to the C-terminus of the second Cas9. In some embodiments, the NLS is fused to the fusion protein via one or more linkers. In some embodiments, the NLS is fused to the fusioin protein without a linker.

[00197] In some embodiments, the UGI comprises a wild type UGI or a UGI as set forth in SEQ ID NO: 553. In some embodiments, the UGI proteins provided herein include fragments of UGI and proteins homologous to a UGI or a UGI fragment. For example, in some embodiments, a UGI comprises a fragment of the amino acid sequence set forth in SEQ ID NO: 553. In some embodiments, a UGI comprises an amino acid sequence homologous to the amino acid sequence set forth in SEQ ID NO: 553 or an amino acid sequence homologous to a fragment of the amino acid sequence set forth in SEQ ID NO: 553. In some embodiments, proteins comprising UGI or fragments of UGI or homologs of UGI or UGI fragments are referred to as "UGI variants." A UGI variant shares homology to UGI, or a fragment thereof. For example a UGI variant is at least about 70% identical, at least about 80% identical, at least about 90% identical, at least about 95% identical, at least about 96% identical, at least about 97% identical, at least about 98% identical, at least about 99% identical, at least about 99.5% identical, or at least about 99.9% to a wild type UGI or a UGI as set forth in SEQ ID NO: 553. In some embodiments, the UGI variant comprises a fragment of UGI, such that the fragment is at least about 70% identical, at least about 80% identical, at least about 90% identical, at least about 95% identical, at least about 96% identical, at least about 97% identical, at least about 98% identical, at least about 99% identical, at least about 99.5% identical, or at least about 99.9% to the corresponding fragment of wild type UGI or a UGI as set forth in SEQ ID NO: 553. In some embodiments, the UGI comprises the following amino acid sequence: >sp|P14739|UNGI_BPPB2 Uracil-DNA glycosylase inhibitor

MT LSDIIEKETGKQLVIQESILMLPEEVEEVIG KPESDILVHTAYDESTDENVMLLT SD APEYKP W AL VIQD SNGE KIKML (SEQ ID NO: 553)

[00198] Suitable UGI protein and nucleotide sequences are provided herein and additional suitable UGI sequences are known to those in the art, and include, for example, those published in Wang et al., Uracil-DNA glycosylase inhibitor gene of bacteriophage PBS2 encodes a binding protein specific for uracil-DNA glycosylase. J. Biol. Chem.

264: 1163-1171(1989); Lundquist et al., Site-directed mutagenesis and characterization of uracil-DNA glycosylase inhibitor protein. Role of specific carboxylic amino acids in complex formation with Escherichia coli uracil-DNA glycosylase. J. Biol. Chem. 272:21408- 21419(1997); Ravishankar et al., X-ray analysis of a complex of Escherichia coli uracil DNA glycosylase (EcUDG) with a proteinaceous inhibitor. The structure elucidation of a prokaryotic UDG. Nucleic Acids Res. 26:4880-4887(1998); and Putnam et al., Protein mimicry of DNA from crystal structures of the uracil-DNA glycosylase inhibitor protein and its complex with Escherichia coli uracil-DNA glycosylase. J. Mol. Biol. 287:331-346(1999), the entire contents of each are incorporated herein by reference.

[00199] It should be appreciated that additional proteins may be uracil glycosylase inhibitors. For example, other proteins that are capable of inhibiting (e.g., sterically blocking) a uracil-DNA glycosylase base-excision repair enzyme are within the scope of this disclosure. In some embodiments, a uracil glycosylase inhibitor is a protein that binds DNA. In some embodiments, a uracil glycosylase inhibitor is a protein that binds single-stranded DNA. For example, a uracil glycosylase inhibitor may be a Erwinia tasmaniensis single- stranded binding protein. In some embodiments, the single-stranded binding protein comprises the amino acid sequence (SEQ ID NO: 303). In some embodiments, a uracil glycosylase inhibitor is a protein that binds uracil. In some embodiments, a uracil glycosylase inhibitor is a protein that binds uracil in DNA. In some embodiments, a uracil glycosylase inhibitor is a catalytically inactive uracil DNA-glycosylase protein. In some embodiments, a uracil glycosylase inhibitor is a catalytically inactive uracil DNA-glycosylase protein that does not excise uracil from the DNA. For example, a uracil glycosylase inhibitor is a UdgX. In some embodiments, the UdgX comprises the amino acid sequence (SEQ ID NO: 304). As another example, a uracil glycosylase inhibitor is a catalytically inactive UDG. In some embodiments, a catalytically inactive UDG comprises the amino acid sequence (SEQ ID NO: 305). It should be appreciated that other uracil glycosylase inhibitors would be apparent to the skilled artisan and are within the scope of this disclosure. Erwinia tasmaniensis SSB (themostable single-stranded DNA binding protein) MASRGVNKVILVGNLGQDPEVRYMPNGGAVANITLATSESWRDKQTGETKEKTEW HRVVLFGKLAEVAGEYLRKGSQVYIEGALQTRKWTDQAGVEKYTTEVVVNVGGT MQMLGGRSQGGGASAGGQNGGSNNGWGQPQQPQGGNQFSGGAQQQARPQQQPQ QNNAPANNEPPIDFDDDIP (SEQ ID NO: 303)

UdgX (binds to Uracil in DNA but does not excise)

MAGAQDFVPHTADLAELAAAAGECRGCGLYRDATQAVFGAGGRSARF MIGEQPG DKEDLAGLPFVGPAGRLLDRALEAADIDRDALYVTNAVKHFKFTRAAGGKRRIHKT P SRTEVVACRPWLIAEMT S VEPD VVVLLGAT AAK ALLGNDFRVTQFIRGEVLHVDD V PGDPALVATVHPSSLLRGPKEERESAFAGLVDDLRVAADVRP (SEQ ID NO: 304)

UDG (catalytically inactive human UDG, binds to Uracil in DNA but does not excise)

MIGQKTL YSFF SP SP ARKRHAP SPEP AVQGTGVAGVPEESGD AA AIP AKK AP AGQEE

PGTPPSSPLSAEQLDRIQRNKAAALLRLAARNVPVGFGESWKKHLSGEFGKPYFIKL

MGFVAEERKHYTVYPPPHQVFTWTQMCDIKDVKVVILGQEPYHGPNQAHGLCFSV

QRPVPPPPSLENIYKELSTDIEDFVHPGHGDLSGWAKQGVLLLNAVLTVRAHQANSH

KERGWEQFTDAVVSWLNQNSNGLVFLLWGSYAQKKGSAIDRKRHHVLQTAHPSPL

SVYRGFFGCRHFSKTNELLQKSGKKPIDWKEL (SEQ ID NO: 305)

High Fidelity Cas9

[00200] Some aspects of the disclosure provide high fidelity Cas9 proteins. In some embodiments, high fidelity Cas9 proteins have decreased electrostatic interactions between the Cas9 protein and a sugar-phosphate backbone of a DNA, as compared to a wild-type Cas9 domain. In some embodiments, any of the Cas9 proteins provided herein comprise one or more mutations that decrease the association between the Cas9 protein and a sugar-phosphate backbone of a DNA. In some embodiments, any of the Cas9 proteins provided herein comprise one or more mutations that decrease the association between the Cas9 protein and a sugar-phosphate backbone of a DNA by at least 5%, at least 10%, at least 15%, at least 20%, at least 25%, at least 30%, at least 35%, at least 40%, at least 45%, at least 50%, at least 60%, at least 70%, at least 80%, at least 90%, or at least 95%. In some embodiments, any of the Cas9 proteins provided herein comprise one or more of a N497X, a R661X, a Q695X, and/or a Q926X mutation of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262, wherein X is any amino acid. In some embodiments, any of the Cas9 proteins provided herein comprise one or more of a N497A, a R661 A, a Q695A, and/or a Q926A mutation of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262. In some embodiments, the Cas9 protein comprises a D10A mutation of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10- 262. In some embodiments, the Cas9 protein comprises the amino acid sequence as set forth in SEQ ID NO: 306. High fidelity Cas9 proteins have been described in the art and would be apparent to the skilled artisan. For example, high fidelity Cas9 proteins have been described in Kleinstiver, B.P., et al. "High-fidelity CRISPR-Cas9 nucleases with no detectable genome- wide off-target effects." Nature 529, 490-495 (2016); and Slaymaker, I.M., et al. "Rationally engineered Cas9 nucleases with improved specificity." Science 351, 84-88 (2015); the entire contents of each are incorporated herein by reference. It should be appreciated that, based on the present disclosure and knowledge in the art, that mutations in any Cas9 protein may be generated to make high fidelity Cas9 proteins that have decreased electrostatic interactions between the Cas9 protein and a sugar-phosphate backbone of a DNA, as compared to a wild- type Cas9 domain.

Cas9 domain where mutations relative to Cas9 of SEQ ID NO: 9 are shown in bold and underlines.

MDKKYSIGLDIGTNSVGWAVITDEYKVPSKKFKVLGNTDRHSIKKNLIGALLFDSGE T AE ATRLi¾T ARRR YTRRKNRIC YLQEIF SNEMAK VDD SFFHRLEE SFL VEEDKKHE RHPIFGNIVDEVAYHEKYPTIYHLRKKLVDSTDKADLRLIYLALAHMIKFRGHFLIEG DLNPDNSDVDKLFIQLVQTYNQLFEENPINASGVDAKAILSARLSKSRRLENLIAQLP GEKKNGLF GNLI AL SLGLTPNFK SNFDL AED AKLQL SKDT YDDDLDNLL AQIGDQ Y A DLFLAAKNLSDAILLSDILRVNTEITKAPLSASMIKRYDEHHQDLTLLKALVRQQLPE KYKEIFFDQSKNGYAGYIDGGASQEEFYKFIKPILEKMDGTEELLVKLNREDLLRKQR TFDNGSIPHQIHLGELHAILRRQEDFYPFLKDNREKIEKILTFRIPYYVGPLARGNSRFA WMTRKSEETITPWNFEEVVDKGASAQSFIERMTAFDKNLPNEKVLPKHSLLYEYFTV YNELTKVK Y VTEGMRKP AFL S GEQKK AIVDLLFKTNRK VT VKQLKED YFKKIECFD SVEISGVEDRFNASLGTYHDLLKIIKDKDFLDNEENEDILEDIVLTLTLFEDREMIEERL KTYAHLFDDKVMKQLKRRRYTGWGALSRKLINGIRDKQSGKTILDFLKSDGFANRN FMALIHDDSLTFKEDIQKAQVSGQGDSLHEHIANLAGSPAIKKGILQTVKVVDELVK VMGRHKPENIVIEMARENQTTQKGQKNSRERMKRIEEGIKELGSQILKEHPVENTQL

Q EKLYLYYLQNGRDMYVDQELDINRLSDYDVDHIVPQSFLKDDSID KVLTRSDK RGKSDNVPSEEVVKKMKNYWRQLLNAKLITQRKFD LTKAERGGLSELDKAGFIK

RQLVETRAITKHVAQILDSRMNTKYDE DKLIREVKVITLKSKLVSDFRKDFQFYKV

REF NYHHAHDAYLNAVVGTALIKKYPKLESEFVYGDYKVYDVRKMIAKSEQEIGK

ATAKYFFYSNF NFFKTEITLANGEIRKRPLIETNGETGEIVWDKGRDFATVRKVLSM

PQVNIVKKTEVQTGGFSKESILPKRNSDKLIARKKDWDPKKYGGFDSPTVAYSVLVV

AKVEKGKSKKLKSVKELLGITF ERSSFEK PIDFLEAKGYKEVKKDLIIKLPKYSLFE

LENGRKRMLASAGELQKG ELALPSKYVNFLYLASHYEKLKGSPED EQKQLFVEQ

HKHYLDEIIEQISEFSKRVILADA LDKVLSAYNKHRDKPIREQAENIIHLFTLTNLGA

P A AFK YFDTTIDRKRYT S TKE VLD ATLIHQ S ITGL YETRIDL S QLGGD (SEQ ID NO:

306)

Cas9 Proteins with Reduced PAM Exclusivity

[00201] Some aspects of the disclosure provide Cas9 proteins that have different PAM specificities. Typically, Cas9 proteins, such as Cas9 from S. pyogenes (spCas9), require a canonical NGG PAM sequence to bind a particular nucleic acid region. This may limit the ability to of the Cas9 protein to bind to a particular nucleotide sequence within a genome. Accordingly, in some embodiments, any of the Cas proteins provided herein may be capable of binding a nucleotide sequence that does not contain a canonical (e.g., NGG) PAM sequence. For example, Cas9 proteins that bind non-canonical PAM sequences have been described in Kleinstiver, B. P., et al., "Engineered CRISPR-Cas9 nucleases with altered PAM specificities" Nature 523, 481-485 (2015); and Kleinstiver, B. P., et al., "Broadening the targeting range of Staphylococcus aureus CRISPR-Cas9 by modifying PAM recognition" Nature Biotechnology 33, 1293-1298 (2015); the entire contents of each are hereby incorporated by reference.

[00202] In some embodiments, the Cas9 protein is a Cas9 protein from Staphylococcus aureus (SaCas9). In some embodiments, the SaCas9 protein is a nuclease active SaCas9, a nuclease inactive SaCas9 (SaCas9d), or a SaCas9 nickase (SaCas9n). In some embodiments, the SaCas9 comprises the amino acid sequence SEQ ID NO: 307. In some embodiments, the SaCas9 comprises a N579X mutation of SEQ ID NO: 307, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 9-262, wherein X is any amino acid except for N. In some embodiments, the SaCas9 comprises a N579A mutation of SEQ ID NO: 307, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262. In some embodiments, the SaCas9 protein, the SaCas9d protein, or the SaCas9n protein can bind to a nucleic acid seuqnce having a non-canonical PAM. In some embodiments, the SaCas9 protein, the SaCas9d protein, or the SaCas9n protein can bind to a nucleic acid sequence having a NNGRRT PAM sequence. In some embodiments, the SaCas9 protein comprises one or more of a E781X, N967X, or R1014X mutation of SEQ ID NO: 307, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262, wherein X is any amino acid. In some embodiments, the SaCas9 protein comprises one or more of a E781K, N967K, or R1014H mutation of SEQ ID NO: 307, or one or more corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262. In some embodiments, the SaCas9 protein comprises a E781K, a N967K, and a R1014H mutation of SEQ ID NO: 307, or corresponding mutations in any of the amino acid sequences provided in SEQ ID NOs: 10-262. It should be appreciated that these mutations may be combined with any of the other mutations provided herein

[00203] In some embodiments, the Cas9 protein of any of the fusion proteins provided herein comprises an amino acid sequence that is at least 60%, at least 65%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or at least 99.5% identical to any one of SEQ ID NOs: 307-309. In some embodiments, the Cas9 protein of any of the fusion proteins provided herein comprises the amino acid sequence of any one of SEQ ID NOs: 307-309. In some embodiments, the Cas9 protein of any of the fusion proteins provided herein consists of the amino acid sequence of any one of SEQ ID NOs: 307-309.

Exemplary SaCas9 sequence

KRNYILGLDIGITSVGYGIIDYETRDVIDAGVRLFKEANVENNEGRRSKRGARRLKRR RRHRIQRVKKLLFDYNLLTDHSELSGINPYEARVKGLSQKLSEEEFSAALLHLAKRRG VHNVNEVEEDTGNELSTKEQISRNSKALEEKYVAELQLERLKKDGEVRGSF RFKTS DYVKEAKQLLKVQKAYHQLDQSFIDTYIDLLETRRTYYEGPGEGSPFGWKDIKEWY EMLMGHCTYFPEELRSVKYAYNADLYNALNDLNNLVITRDENEKLEYYEKFQIIENV FKQKKKPTLKQIAKEILVNEEDIKGYRVTSTGKPEFTNLKVYHDIKDITARKEIIENAE LLDQIAKILTIYQSSEDIQEELTNLNSELTQEEIEQISNLKGYTGTHNLSLKAINLILDEL WHTNDNQIAIFNRLKLVPKKVDLSQQKEIPTTLVDDFILSPVVKRSFIQSIKVINAIIKK YGLPNDIIIELAREKNSKDAQKMINEMQKRNRQTNERIEEIIRTTGKENAKYLIEKIKL HDMQEGKCLYSLEAIPLEDLLNNPFNYEVDHIIPRSVSFDNSFNNKVLVKQEENSKK GNRTPFQ YLS S SD SKIS YETFKKHILNLAKGKGRISKTKKE YLLEERDINRF S VQKDFI RNLVDTRYATRGLMNLLRSYFRVN LDVKVKSINGGFTSFLRRKWKFKKERNKG

YKHHAEDALIIANADFIFKEWKKLDKAKKVMENQMFEEKQAESMPEIETEQEYKEIF

ITPHQIKHIKDFKDYKYSHRVDKKP RELINDTLYSTRKDDKGNTLIVNNLNGLYDK

D DKLKKLINKSPEKLLMYHHDPQTYQKLKLF EQYGDEK PLYKYYEETGNYLTK

YSKKDNGPVIKKIKYYG KLNAHLDITDDYPNSR KVVKLSLKPYRFDVYLDNGVY

KFVTVKNLDVn KENYYEVNSKCYEEAKKLKKISNQAEFIASFYN DLIKINGELYRV

IGVN DLLl^ffiVNMroiTYREYLE MNDKRPPRIIKTIASKTQSIKKYSTDILG LYE

VKSKKHPQIIKKG (SEQ ID NO: 307)

Residue N579 of SEQ ID NO: 307, which is underlined and in bold, may be mutated (e.g., to a A579) to yield a SaCas9 nickase.

Exemplary SaCas9n sequence

KRNYILGLDIGITSVGYGIIDYETRDVIDAGVRLFKEANVENNEGRRSKRGARRLKRR

RRHRIQRVKKLLFDYNLLTDHSELSGINPYEARVKGLSQKLSEEEFSAALLHLAKRRG

VHNVNEVEEDTGNELSTKEQISRNSKALEEKYVAELQLERLKKDGEVRGSF RFKTS

DYVKEAKQLLKVQKAYHQLDQSFIDTYIDLLETRRTYYEGPGEGSPFGWKDIKEWY

EMLMGHCTYFPEELRSVKYAYNADLYNALNDLNNLVITRDENEKLEYYEKFQIIENV

FKQKKKPTLKQIAKEILVNEEDIKGYRVTSTGKPEFTNLKVYHDIKDITARKEIIENAE

LLDQIAKILTIYQ S SEDIQEELTNLNSELTQEEIEQISNLKGYTGTHNL SLK AINLILDEL

WHTNDNQIAIFNRLKLVPKKVDLSQQKEIPTTLVDDFILSPVVKRSFIQSIKVINAIIKK

YGLPNDIIIELAREKNSKDAQKMINEMQKRNRQTNERIEEIIRTTGKENAKYLIEKIKL

HDMQEGKCLYSLEAIPLEDLLNNPFNYEVDHIIPRSVSFDNSFNNKVLVKQEEASKK

GNRTPFQ YLS S SD SKIS YETFKKHILNLAKGKGRISKTKKE YLLEERDINRF S VQKDFI

NRNLVDTRYATRGLMNLLRSYFRVNNLDVKVKSINGGFTSFLRRKWKFKKERNKG

YKHHAEDALIIANADFIFKEWKKLDKAKKVMENQMFEEKQAESMPEIETEQEYKEIF

ITPHQIKHIKDFKDYKYSHRVDKKPNRELINDTLYSTRKDDKGNTLIVNNLNGLYDK

DNDKLKKLINKSPEKLLMYHHDPQTYQKLKLFMEQYGDEKNPLYKYYEETGNYLTK

YSKKDNGPVIKKIKYYGNKLNAHLDITDDYPNSRNKVVKLSLKPYRFDVYLDNGVY

KFVTVKNLDVn KENYYEVNSKCYEEAKKLKKISNQAEFIASFYNNDLIKINGELYRV

IGVNNDLLNRIEVNMIDITYREYLENMNDKRPPRIIKTIASKTQSIKKYSTDILGNLYE

VKSKKHPQIIKKG (SEQ ID NO: 308).

Residue A579 of SEQ ID NO: 308, which can be mutated from N579 of SEQ ID NO: 307 to yield a SaCas9 nickase, is underlined and in bold. Exemplary SaKKH Cas9

KRNYILGLDIGITSVGYGiroYETRDVroAGVRLFKEANVEN EGRRSKRGARRLKRR

RRHRIQRVKKLLFDYNLLTDHSELSGINPYEARVKGLSQKLSEEEFSAALLHLAKRRG

VHNVNEVEEDTG ELSTKEQISRNSKALEEKYVAELQLERLKKDGEVRGSF RFKTS

DYVKEAKQLLKVQKAYHQLDQSFIDTYIDLLETRRTYYEGPGEGSPFGWKDIKEWY

EMLMGHCTYFPEELRSVKYAYNADLYNAL DLNNLVITRDE EKLEYYEKFQIIENV

FKQKKKPTLKQIAKEILV EEDIKGYRVTSTGKPEFTNLKVYHDIKDITARKEIIENAE

LLDQIAKILTIYQ S SEDIQEELTNLNSELTQEEIEQISNLKGYTGTHNL SLK AINLILDEL

WHTNDNQIAIF RLKLVPKKVDLSQQKEIPTTLVDDFILSPVVKRSFIQSIKVINAIIKK

YGLP DIIIELAREKNSKDAQKMINEMQKR RQT ERIEEIIRTTGKENAKYLIEKIKL

HDMQEGKCLYSLEAIPLEDLLNNPFNYEVDHIIPRSVSFDNSFNNKVLVKQEEASKK

G RTPFQ YLS S SD SKIS YETFKKHILNLAKGKGRISKTKKE YLLEERDINRF S VQKDFI RNLVDTRYATRGLMNLLRSYFRVN LDVKVKSINGGFTSFLRRKWKFKKER KG

YKHHAEDALIIANADFIFKEWKKLDKAKKVMENQMFEEKQAESMPEIETEQEYKEIF

ITPHQIKHIKDFKDYKYSHRVDKKP R LINDTLYSTRKDDKGNTLIVNNLNGLYDK

D DKLKKLINKSPEKLLMYHHDPQTYQKLKLF EQYGDEK PLYKYYEETGNYLTK

YSKKDNGPVIKKIKYYG KLNAHLDITDDYPNSR KVVKLSLKPYRFDVYLDNGVY

KFVTVKNLDVn KENYYEVNSKCYEEAKKLKKISNQAEFIASFY DLIKINGELYRV

IGVNNDLLNRIEVNMIDITYREYLENMNDKRPPZ/IIKTIASKTQSIKKYSTDILGNLYE

VKSKKHPQIIKKG (SEQ ID NO: 309).

Residue A579 of SEQ ID NO: 309, which can be mutated from N579 of SEQ ID NO: 307 to yield a SaCas9 nickase, is underlined and in bold. Residues K781, K967, and H1014 of SEQ ID NO: 309, which can be mutated from E781, N967, and R1014 of SEQ ID NO: 307 to yield a SaKKH Cas9 are underlined and in italics.

[00204] In some embodiments, the Cas9 protein is a Cas9 protein from Streptococcus pyogenes (SpCas9). In some embodiments, the SpCas9 protein is a nuclease active SpCas9, a nuclease inactive SpCas9 (SpCas9d), or a SpCas9 nickase (SpCas9n). In some embodiments, the SpCas9 comprises the amino acid sequence SEQ ID NO: 9. In some embodiments, the SpCas9 comprises a D10X mutation of SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262, wherein X is any amino acid except for D. In some embodiments, the SpCas9 comprises a D10A mutation of SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262. In some embodiments, the SpCas9 protein, the SpCas9d protein, or the SpCas9n protein can bind to a nucleic acid seuqnce having a non-canonical PAM. In some embodiments, the SpCas9 protein, the SpCas9d protein, or the SpCas9n protein can bind to a nucleic acid sequence having a NGG, a NGA, or a NGCG PAM sequence. In some embodiments, the SpCas9 protein comprises one or more of a Dl 135X, R1335X, and

T1337X mutation of SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262, wherein X is any amino acid. In some embodiments, the SpCas9 protein comprises one or more of a Dl 135E, R1335Q, and T1337R mutation of SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262. In some embodiments, the SpCas9 protein comprises a Dl 135E, a R1335Q, and a T1335R mutation of SEQ ID NO: 9, or corresponding mutations in any of the amino acid sequences provided in SEQ ID NOs: 10-262. In some embodiments, the SpCas9 protein comprises one or more of a Dl 135X, R1335X, and T1337X mutation of SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262, wherein X is any amino acid. In some embodiments, the SpCas9 protein comprises one or more of a Dl 135V, R1335Q, and T1337R mutation of SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262. In some embodiments, the SpCas9 protein comprises a Dl 135V, a R1335Q, and a T1337R mutation of SEQ ID NO: 9, or corresponding mutations in any of the amino acid sequences provided in SEQ ID NOs: 10-262. In some embodiments, the SpCas9 protein comprises one or more of a D1135X, G1218X, R1335X, and T1337X mutation of SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262, wherein X is any amino acid. In some embodiments, the SpCas9 protein comprises one or more of a D1135V, G1218R, R1335Q, and T1337R mutation of SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262. In some embodiments, the SpCas9 protein comprises a Dl 135V, a G1218R, a R1335Q, and a T1337R mutation of SEQ ID NO: 9, or corresponding mutations in any of the amino acid sequences provided in SEQ ID NOs: 10-262. It should be appreciated that these mutations may be combined with any of the other mutations provided herein

[00205] In some embodiments, the Cas9 protein of any of the fusion proteins provided herein comprises an amino acid sequence that is at least 60%, at least 65%, at least 70%, at least 75%, at least 80%, at least 85%, at least 90%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or at least 99.5% identical to any one of SEQ ID NOs: 9, 310-313. In some embodiments, the Cas9 domain of any of the fusion proteins provided herein comprises the amino acid sequence of any one of SEQ ID NOs: 9, 310-313. In some embodiments, the Cas9 domain of any of the fusion proteins provided herein consists of the amino acid sequence of any one of SEQ ID NOs: 9, 310-313.

Exemplary SpCas9

MDKKYSIGLDIGTNSVGWAVITDEYKVPSKKFKVLGNTDRHSIKKNLIGALLFDSGE

T AE ATRLKRT ARRR YTRRK RIC YLQEIF S EMAK VDD SFFHRLEE SFL VEEDKKHE

RHPIFGNIVDEVAYHEKYPTIYHLRKKLVDSTDKADLRLIYLALAHMIKFRGHFLIEG

DLNPDNSDVDKLFIQLVQTYNQLFEENPINASGVDAKAILSARLSKSRRLENLIAQLP

GEKKNGLFG LIALSLGLTPNFKSNFDLAEDAKLQLSKDTYDDDLD LLAQIGDQYA

DLFLAAK LSDAILLSDILRVNTEITKAPLSASMIKRYDEHHQDLTLLKALVRQQLPE

KYKEIFFDQSKNGYAGYIDGGASQEEFYKFIKPILEKMDGTEELLVKL REDLLRKQR

TFDNGSIPHQIHLGELHAILRRQEDFYPFLKD REKIEKILTFRIPYYVGPLARGNSRFA

WMTRKSEETITPW FEEVVDKGASAQSFIERMT FDKNLP EKVLPKHSLLYEYFTV

YNELTKVK Y VTEGMRKP AFL S GEQKK AIVDLLFKT RK VT VKQLKED YFKKIECFD

SVEISGVEDRFNASLGTYHDLLKIIKDKDFLD EE EDILEDIVLTLTLFEDREMIEERL

KTYAHLFDDKVMKQLKRRRYTGWGRLSRKLINGIRDKQSGKTILDFLKSDGFA RN

FMQLIHDDSLTFKEDIQKAQVSGQGDSLHEHIANLAGSPAIKKGILQTVKVVDELVK

VMGRHKPENIVIEMARENQTTQKGQKNSRERMKRIEEGIKELGSQILKEHPVENTQL

Q EKLYLYYLQNGRDMYVDQELDINRLSDYDVDHIVPQSFLKDDSID KVLTRSDK RGKSDNVPSEEVVKKMKNYWRQLLNAKLITQRKFD LTKAERGGLSELDKAGFIK

RQLVETRQITKHVAQILDSRMNTKYDE DKLIREVKVITLKSKLVSDFRKDFQFYKV

REr NYHHAHDAYLNAVVGTALIKKYPKLESEFVYGDYKVYDVRKMIAKSEQEIGK

ATAKYFFYSNF NFFKTEITLANGEIRKRPLIETNGETGEIVWDKGRDFATVRKVLSM

PQVNIVKKTEVQTGGFSKESILPKRNSDKLIARKKDWDPKKYGGFDSPTVAYSVLVV

AKVEKGKSKKLKSVKELLGITF ERSSFEK PIDFLEAKGYKEVKKDLIIKLPKYSLFE

LENGRKRMLASAGELQKGNELALPSKYVNFLYLASHYEKLKGSPEDNEQKQLFVEQ

HKHYLDEIIEQISEFSKRVILADA LDKVLSAYNKHRDKPIREQAENIIHLFTLTNLGA

P A AFK YFDTTIDRKRYT S TKE VLD ATLIHQ S ITGL YETRIDL S QLGGD (SEQ ID NO: 9)

Exemplary SpCas9n

DKKYSIGLAIGTNSVGWAVITDEYKVPSKKFKVLGNTDRHSIKKNLIGALLFDSGETA E ATRLKRT ARRR YTRRKNRIC YLQEIF SNEMAK VDD SFFHRLEESFL VEEDKKHERH PIFGNIVDEVAYHEKYPTrYHLRKKLVDSTDKADLRLIYLALAHMIKFRGHFLIEGDL NPDNSDVDKLFIQLVQTYNQLFEENPINASGVDAKAILSARLSKSRRLENLIAQLPGE KKNGLFGNLIALSLGLTP FKS FDLAEDAKLQLSKDTYDDDLD LLAQIGDQYADL

FLAAKNLSDAILLSDILRVNTEITKAPLSASMIKRYDEHHQDLTLLKALVRQQLPEKY

KEIFFDQSKNGYAGYIDGGASQEEFYKFIKPILEKMDGTEELLVKL REDLLRKQRTF

DNGSIPHQIHLGELHAILRRQEDFYPFLKD REKIEKILTFRIPYYVGPLARGNSRFAW

MTRKSEETITPW FEEVVDKGASAQSFIERMT FDK LP EKVLPKHSLLYEYFTVY ELTK VK Y VTEGMRKP AFL S GEQKK AIVDLLFKTNRK VT VKQLKED YFKKIECFD S

VEISGVEDRFNASLGTYHDLLKIIKDKDFLDNEENEDILEDIVLTLTLFEDREMIEERL

KTYAHLFDDKVMKQLKRRRYTGWGRLSRKLINGIRDKQSGKTILDFLKSDGFA RN

FMQLIHDDSLTFKEDIQKAQVSGQGDSLHEHIANLAGSPAIKKGILQTVKVVDELVK

VMGRHKPENIVIEMARENQTTQKGQKNSRERMKRIEEGIKELGSQILKEHPVENTQL

Q EKLYLYYLQNGRDMYVDQELDINRLSDYDVDHIVPQSFLKDDSID KVLTRSDK RGKSDNVPSEEVVKKMKNYWRQLLNAKLITQRKFD LTKAERGGLSELDKAGFIK

RQLVETRQITKHVAQILDSRMNTKYDE DKLIREVKVITLKSKLVSDFRKDFQFYKV

REF NYHHAHDAYLNAVVGTALIKKYPKLESEFVYGDYKVYDVRKMIAKSEQEIGK

ATAKYFFYSNF NFFKTEITLANGEIRKRPLIETNGETGEIVWDKGRDFATVRKVLSM

PQVNIVKKTEVQTGGFSKESILPKRNSDKLIARKKDWDPKKYGGFDSPTVAYSVLVV

AKVEKGKSKKLKSVKELLGITF ERSSFEK PIDFLEAKGYKEVKKDLIIKLPKYSLFE

LENGRKRMLASAGELQKGNELALPSKYVNFLYLASHYEKLKGSPEDNEQKQLFVEQ

HKHYLDEIIEQISEFSKRVILADA LDKVLSAYNKHRDKPIREQAENIIHLFTLTNLGA

P A AFK YFDTTIDRKRYT S TKE VLD ATLIHQ S ITGL YETRIDL S QLGGD (SEQ ID NO:

310)

Exemplary SpEQR Cas9

DKKYSIGLAIGTNSVGWAVITDEYKVPSKKFKVLGNTDRHSIKKNLIGALLFDSGETA E ATRLKRT ARRRYTRRKNRIC YLQEIF SNEMAKVDD SFFHRLEESFL VEEDKKHERH PIFGNIVDEVAYHEKYPTrYHLRKKLVDSTDKADLRLIYLALAHMIKFRGHFLIEGDL NPDNSDVDKLFIQLVQTYNQLFEENPINASGVDAKAILSARLSKSRRLENLIAQLPGE KKNGLFGNLIALSLGLTPNFKSNFDLAEDAKLQLSKDTYDDDLDNLLAQIGDQYADL FLAAKNLSDAILLSDILRVNTEITKAPLSASMIKRYDEHHQDLTLLKALVRQQLPEKY KEIFFDQSKNGYAGYIDGGASQEEFYKFIKPILEKMDGTEELLVKLNREDLLRKQRTF DNGSIPHQIHLGELHAILRRQEDFYPFLKDNREKIEKILTFRIPYYVGPLARGNSRFAW MTRKSEETITPWNFEEVVDKGASAQSFIERMTNFDKNLPNEKVLPKHSLLYEYFTVY NELTK VKY VTEGMRKP AFL S GEQKK AIVDLLFKTNRK VT VKQLKED YFKKIECFD S VEISGVEDRFNASLGTYHDLLKIIKDKDFLDNEENEDILEDIVLTLTLFEDREMIEERL KTYAHLFDDKVMKQLKRRRYTGWGRLSRKLINGIRDKQSGKTILDFLKSDGFA RN

FMQLIHDDSLTFKEDIQKAQVSGQGDSLHEHIANLAGSPAIKKGILQTVKVVDELVK

VMGRHKPENIVIEMARENQTTQKGQKNSRERMKRIEEGIKELGSQILKEHPVENTQL

Q EKLYLYYLQNGRDMYVDQELDINRLSDYDVDHIVPQSFLKDDSID KVLTRSDK RGKSDNVPSEEVVKKMKNYWRQLLNAKLITQRKFD LTKAERGGLSELDKAGFIK

RQLVETRQITKHVAQILDSRMNTKYDE DKLIREVKVITLKSKLVSDFRKDFQFYKV

REF NYHHAHDAYLNAVVGTALIKKYPKLESEFVYGDYKVYDVRKMIAKSEQEIGK

ATAKYFFYSNF NFFKTEITLANGEIRKRPLIETNGETGEIVWDKGRDFATVRKVLSM

PQVNIVKKTEVQTGGFSKESILPKRNSDKLIARKKDWDPKKYGGFESPTVAYSVLVV

AKVEKGKSKKLKSVKELLGITF ERSSFEK PIDFLEAKGYKEVKKDLIIKLPKYSLFE

LENGRKRMLASAGELQKG ELALPSKYVNFLYLASHYEKLKGSPED EQKQLFVEQ

HKHYLDEIIEQISEFSKRVILADA LDKVLSAYNKHRDKPIREQAENIIHLFTLTNLGA

PAAFKYFDTTIDRKQYRSTKEVLDATLIHQSITGLYETRIDLSQLGGD (SEQ ID NO:

311)

Residues El 134, Q1334, and R1336 of SEQ ID NO: 311, which can be mutated from Dl 134, R1334, and T1336 of SEQ ID NO: 9 to yield a SpEQR Cas9, are underlined and in bold.

Exemplary SpVQR Cas9

DKKYSIGLAIGTNSVGWAVITDEYKVPSKKFKVLGNTDRHSn KNLIGALLFDSGETA E ATRLKRT ARRRYTRRKNRIC YLQEIF SNEMAKVDD SFFHRLEESFL VEEDKKHERH PIFGNIVDEVAYHEKYPTrYHLRKKLVDSTDKADLRLIYLALAHMIKFRGHFLIEGDL NPDNSDVDKLFIQLVQTYNQLFEENPINASGVDAKAILSARLSKSRRLENLIAQLPGE KKNGLFGNLIALSLGLTPNFKSNFDLAEDAKLQLSKDTYDDDLDNLLAQIGDQYADL FLAAKNLSDAILLSDILRVNTEITKAPLSASMIKRYDEHHQDLTLLKALVRQQLPEKY KEIFFDQSKNGYAGYIDGGASQEEFYKFIKPILEKMDGTEELLVKLNREDLLRKQRTF DNGSIPHQIHLGELHAILRRQEDFYPFLKDNREKIEKILTFRIPYYVGPLARGNSRFAW MTRKSEETITPWNFEEVVDKGASAQSFIERMTNFDKNLPNEKVLPKHSLLYEYFTVY NELTK VK Y VTEGMRKP AFL S GEQKK AIVDLLFKTNRK VT VKQLKED YFKKIECFD S VEISGVEDRFNASLGTYHDLLKIIKDKDFLDNEENEDILEDIVLTLTLFEDREMIEERL KTYAHLFDDKVMKQLKRRRYTGWGRLSRKLINGIRDKQSGKTILDFLKSDGFANRN FMQLIHDDSLTFKEDIQKAQVSGQGDSLHEHIANLAGSPAIKKGILQTVKVVDELVK VMGRHKPENIVIEMARENQTTQKGQKNSRERMKRIEEGIKELGSQILKEHPVENTQL QNEKLYLYYLQNGRDMYVDQELDINRLSDYDVDHIVPQSFLKDDSIDNKVLTRSDK NRGKSDNVPSEEVVKKMKNYWRQLLNAKLITQRKFDNLTKAERGGLSELDKAGFIK RQLVETRQITKHVAQILDSRMNTKYDENDKLIREVKVITLKSKLVSDFRKDFQFYKV

REF NYHHAHDAYLNAVVGTALIKKYPKLESEFVYGDYKVYDVRKMIAKSEQEIGK

ATAKYFFYSNF NFFKTEITLANGEIRKRPLIETNGETGEIVWDKGRDFATVRKVLSM

PQVNIVKKTEVQTGGFSKESILPKRNSDKLIARKKDWDPKKYGGFVSPTVAYSVLVV

AKVEKGKSKKLKSVKELLGITF ERSSFEKNPIDFLEAKGYKEVKKDLIIKLPKYSLFE

LENGRKRMLASAGELQKGNELALPSKYVNFLYLASHYEKLKGSPEDNEQKQLFVEQ

HKHYLDEIIEQISEFSKRVILADANLDKVLSAYNKHRDKPIREQAENIIHLFTLTNLGA

PAAFKYFDTTIDRKQYRSTKEVLDATLIHQSITGLYETRIDLSQLGGD (SEQ ID NO:

312)

Residues VI 134, Q1334, and R1336 of SEQ ID NO: 312, which can be mutated from Dl 134, R1334, and T1336 of SEQ ID NO: 9 to yield a SpVQR Cas9, are underlined and in bold.

Exemplary SpVRER Cas9

DKKYSIGLAIGTNSVGWAVITDEYKVPSKKFKVLGNTDRHSn KNLIGALLFDSGETA E ATRLKRT ARRRYTRRKNRIC YLQEIF SNEMAK VDD SFFHRLEESFL VEEDKKHERH PIFGNIVDEVAYHEKYPTrYHLRKKLVDSTDKADLRLIYLALAHMIKFRGHFLIEGDL NPDNSDVDKLFIQLVQTYNQLFEENPINASGVDAKAILSARLSKSRRLENLIAQLPGE KKNGLFGNLIALSLGLTPNFKSNFDLAEDAKLQLSKDTYDDDLDNLLAQIGDQYADL FLAAKNLSDAILLSDILRVNTEITKAPLSASMIKRYDEHHQDLTLLKALVRQQLPEKY KEIFFDQSKNGYAGYIDGGASQEEFYKFIKPILEKMDGTEELLVKLNREDLLRKQRTF DNGSIPHQIHLGELHAILRRQEDFYPFLKDNREKIEKILTFRIPYYVGPLARGNSRFAW MTRKSEETITPWNFEEVVDKGASAQSFIERMTNFDKNLPNEKVLPKHSLLYEYFTVY NELTK VK Y VTEGMRKP AFL S GEQKK AI VDLLFKTNRK VT VKQLKED YFKKIECFD S VEISGVEDRFNASLGTYHDLLKIIKDKDFLDNEENEDILEDIVLTLTLFEDREMIEERL KTYAHLFDDKVMKQLKRRRYTGWGRLSRKLINGIRDKQSGKTILDFLKSDGFANRN FMQLIHDDSLTFKEDIQKAQVSGQGDSLHEHIANLAGSPAIKKGILQTVKVVDELVK VMGRHKPENIVIEMARENQTTQKGQKNSRERMKRIEEGIKELGSQILKEHPVENTQL QNEKLYLYYLQNGRDMYVDQELDINRLSDYDVDHIVPQSFLKDDSIDNKVLTRSDK NRGKSDNVPSEEVVKKMKNYWRQLLNAKLITQRKFDNLTKAERGGLSELDKAGFIK RQLVETRQITKHVAQILDSRMNTKYDENDKLIREVKVITLKSKLVSDFRKDFQFYKV REF NYHHAHDAYLNAVVGTALIKKYPKLESEFVYGDYKVYDVRKMIAKSEQEIGK ATAKYFFYSNFMNFFKTEITLANGEIRKRPLIETNGETGEIVWDKGRDFATVRKVLSM PQVNIVKKTEVQTGGFSKESILPKRNSDKLIARKKDWDPKKYGGFVSPTVAYSVLVV AKVEKGKSKKLKSVKELLGITFMERSSFEKNPIDFLEAKGYKEVKKDLIIKLPKYSLFE LENGRKRMLASARELQKG ELALPSKYVNFLYLASHYEKLKGSPED EQKQLFVEQ HKHYLDEIIEQISEFSKRVILADA LDKVLSAYNKHRDKPIREQAENIIHLFTLTNLGA PAAFKYFDTTIDRKEYRSTKEVLDATLIHQSITGLYETRIDLSQLGGD (SEQ ID NO: 313)

[00206] Residues VI 134, R1217, Q1334, and R1336 of SEQ ID NO: 313, which can be mutated from Dl 134, G1217, R1334, and T1336 of SEQ ID NO: 9 to yield a SpVRER Cas9, are underlined and in bold.

Cas9 complexes with guide RNAs

[00207] Some aspects of this disclosure provide complexes comprising a Cas9 protein or a Cas9 fusion protein as provided herein, and a guide RNA bound to the Cas9 protein or the Cas9 fusion protein. In some embodiments, the guide RNA is about 15-100 nucleotides long and comprises a sequence of at least 10 contiguous nucleotides that is complementary to a target sequence. In some embodiments, the guide RNA is 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, or 50 nucleotides long. In some embodiments, the guide RNA comprises a sequence of 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, or 40 contiguous nucleotides that is complementary to a target sequence. In some

embodiments, the target sequence is a DNA sequence. In some embodiments, the target sequence is a sequence in the genome of a mammal. In some embodiments, the target sequence is a sequence in the genome of a human. In some embodiments, the 3' end of the target sequence is not immediately adjacent to the canonical PAM sequence (5'-NGG-3').

[00208] Some aspects of the disclosure provide complexes comprising a first guide RNA bound to a Cas9 protein of a fusion protein, and a second guide RNA bound to a second Cas9 protein of the fusion protein. In some embodiments, the first guide RNA is about 15- 100 nucleotides long and comprises a sequence of at least 10 contiguous nucleotides that is complementary to a first target sequence and the second guide RNA is about 15-100 nucleotides long and comprises a sequence of at least 10 contiguous nucleotides that is complementary to a second target sequence. In some embodiments, the first guide RNA and/or the second guide RNA is 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, or 50 nucleotides long. In some embodiments, the first guide RNA and the second guide RNA are different. In some embodiments, the first guide RNA comprises a sequence of 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, or 40 contiguous nucleotides that is complementary to a first target sequence and wherein the second guide RNA comprises a sequence of 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, or 40 contiguous nucleotides that is complementary to a second target sequence.

[00209] In some embodiments, first target sequence and the second target sequence are different. In some embodiments, the first target sequence and the second target sequence are DNA sequences. In some embodiments, the first target sequence and the second target sequence are in the genome of a mammal. In some embodiments, the first target sequence and the second target sequence are in the genome of a human. In some embodiments, the first target sequence is within at least 5, 10, 15, 20, 25, 30, 35, 40, 45, 50, 60, 70, 80, 90, 100, 150, or 200 nucleotides of the second target sequence. In some embodiments, the 3 '-end of the first target sequence is not immediately adjacent to the canonical PAM sequence (5'- NGG-3 '). In some embodiments, the 3'-end of the second target sequence is not immediately adjacent to the canonical PAM sequence (5'-NGG-3 ').

Methods of using Cas9 fusion proteins

[00210] Some aspects of this disclosure provide methods of using the Cas9 proteins, fusion proteins, or complexes provided herein. For example, some aspects of this disclosure provide methods comprising contacting a DNA molecule (a) with any of the the Cas9 proteins or fusion proteins provided herein, and with at least one guide RNA, wherein the guide RNA is about 15-100 nucleotides long and comprises a sequence of at least 10 contiguous nucleotides that is complementary to a target sequence; or (b) with a Cas9 protein, a Cas9 fusion protein, or a Cas9 protein or fusion protein complex with at least one gRNA as provided herein. In some embodiments, the 3' end of the target sequence is not immediately adjacent to the canonical PAM sequence (5'-NGG-3 '). In some embodiments, the 3' end of the target sequence is immediately adjacent to an AGC, GAG, TTT, GTG, or CAA sequence.

[00211] In some embodiments, the target DNA sequence comprises a sequence associated with a disease or disorder. In some embodiments, the target DNA sequence comprises a point mutation associated with a disease or disorder. In some embodiments, the activity of the Cas9 protein, the Cas9 fusion protein, or the complex results in a correction of the point mutation. In some embodiments, the target DNA sequence comprises a T→C point mutation associated with a disease or disorder, and wherein the deamination of the mutant C base results in a sequence that is not associated with a disease or disorder. In some

embodiments, the target DNA sequence encodes a protein and wherein the point mutation is in a codon and results in a change in the amino acid encoded by the mutant codon as compared to the wild-type codon. In some embodiments, the deamination of the mutant C results in a change of the amino acid encoded by the mutant codon. In some embodiments, the deamination of the mutant C results in the codon encoding the wild-type amino acid. In some embodiments, the contacting is in vivo in a subject. In some embodiments, the subject has or has been diagnosed with a disease or disorder. In some embodiments, the disease or disorder is cystic fibrosis, phenylketonuria, epidermolytic hyperkeratosis (EHK), Charcot- Marie-Toot disease type 4J, neuroblastoma (NB), von Willebrand disease (vWD), myotonia congenital, hereditary renal amyloidosis, dilated cardiomyopathy (DCM), hereditary lymphedema, familial Alzheimer's disease, HIV, Prion disease, chronic infantile neurologic cutaneous articular syndrome (CINCA), desmin-related myopathy (DRM), a neoplastic disease associated with a mutant PI3KCA protein, a mutant CTNNB1 protein, a mutant HRAS protein, or a mutant p53 protein.

[00212] Some embodiments provide methods for using the Cas9 DNA editing fusion proteins provided herein. In some embodiments, the fusion protein is used to introduce a point mutation into a nucleic acid by deaminating a target nucleobase, e.g., a C residue. In some embodiments, the deamination of the target nucleobase results in the correction of a genetic defect, e.g., in the correction of a point mutation that leads to a loss of function in a gene product. In some embodiments, the genetic defect is associated with a disease or disorder, e.g., a lysosomal storage disorder or a metabolic disease, such as, for example, type I diabetes. In some embodiments, the methods provided herein are used to introduce a deactivating point mutation into a gene or allele that encodes a gene product that is associated with a disease or disorder. For example, in some embodiments, methods are provided herein that employ a Cas9 DNA editing fusion protein to introduce a deactivating point mutation into an oncogene {e.g., in the treatment of a proliferative disease). A deactivating mutation may, in some embodiments, generate a premature stop codon in a coding sequence, which results in the expression of a truncated gene product, e.g., a truncated protein lacking the function of the full-length protein.

[00213] In some embodiments, the purpose of the methods provide herein is to restore the function of a dysfunctional gene via genome editing. The Cas9 deaminase fusion proteins provided herein can be validated for gene editing-based human therapeutics in vitro, e.g., by correcting a disease-associated mutation in human cell culture. It will be understood by the skilled artisan that the fusion proteins provided herein, e.g., the fusion proteins comprising a Cas9 domain and a nucleic acid deaminase domain can be used to correct any single point T -> C or A -> G mutation. In the first case, deamination of the mutant C back to U corrects the mutation, and in the latter case, deamination of the C that is base-paired with the mutant G, followed by a round of replication, corrects the mutation.

[00214] An exemplary disease-relevant mutation that can be corrected by the provided fusion proteins in vitro or in vivo is the H1047R (A3140G) polymorphism in the PI3KCA protein. The phosphoinositide-3 -kinase, catalytic alpha sub unit (PI3KCA) protein acts to phosphorylate the 3 -OH group of the inositol ring of phosphatidylinositol. The PI3KCA gene has been found to be mutated in many different carcinomas, and thus it is considered to be a potent oncogene.⁵⁰ In fact, the A3140G mutation is present in several NCI-60 cancer cell lines, such as, for example, the HCT116, SKOV3, and T47D cell lines, which are readily available from the American Type Culture Collection (ATCC).⁵¹

[00215] In some embodiments, a cell carrying a mutation to be corrected, e.g., a cell carrying a point mutation, e.g., an A3140G point mutation in ex on 20 of the PI3KCA gene, resulting in a H1047R substitution in the PI3KCA protein, is contacted with an expression construct encoding a Cas9 deaminase fusion protein and an appropriately designed sgRNA targeting the fusion protein to the respective mutation site in the encoding PI3KCA gene. Control experiments can be performed where the sgRNAs are designed to target the fusion enzymes to non-C residues that are within the PI3KCA gene. Genomic DNA of the treated cells can be extracted, and the relevant sequence of the PI3KCA genes PCR amplified and sequenced to assess the activities of the fusion proteins in human cell culture.

[00216] It will be understood that the example of correcting point mutations in

PI3KCA is provided for illustration purposes and is not meant to limit the instant disclosure. The skilled artisan will understand that the instantly disclosed DNA-editing fusion proteins can be used to correct other point mutations and mutations associated with other cancers and with diseases other than cancer including other proliferative diseases.

[00217] The successful correction of point mutations in disease-associated genes and alleles opens up new strategies for gene correction with applications in therapeutics and basic research. Site-specific single-base modification systems like the disclosed fusions of Cas9 and deaminase enzymes or domains also have applications in "reverse" gene therapy, where certain gene functions are purposely suppressed or abolished. In these cases, site-specifically mutating Tip (TGG), Gin (CAA and CAG), or Arg (CGA) residues to premature stop codons (TAA, TAG, TGA) can be used to abolish protein function in vitro, ex vivo, or in vivo.

[00218] The instant disclosure provides methods for the treatment of a subject diagnosed with a disease associated with or caused by a point mutation that can be corrected by a Cas9 DNA editing fusion protein provided herein. For example, in some embodiments, a method is provided that comprises administering to a subject having such a disease, e.g., a cancer associated with a PI3KCA point mutation as described above, an effective amount of a Cas9 deaminase fusion protein that corrects the point mutation or introduces a deactivating mutation into the disease-associated gene. In some embodiments, the disease is a

proliferative disease. In some embodiments, the disease is a genetic disease. In some embodiments, the disease is a neoplastic disease. In some embodiments, the disease is a metabolic disease. In some embodiments, the disease is a lysosomal storage disease. Other diseases that can be treated by correcting a point mutation or introducing a deactivating mutation into a disease-associated gene will be known to those of skill in the art, and the disclosure is not limited in this respect.

[00219] The instant disclosure provides methods for the treatment of additional diseases or disorders, e.g., diseases or disorders that are associated or caused by a point mutation that can be corrected by deaminase-mediated gene editing. Some such diseases are described herein, and additional suitable diseases that can be treated with the strategies and fusion proteins provided herein will be apparent to those of skill in the art based on the instant disclosure. Exemplary suitable diseases and disorders are listed below. It will be understood that the numbering of the specific positions or residues in the respective sequences depends on the particular protein and numbering scheme used. Numbering might be different, e.g., in precursors of a mature protein and the mature protein itself, and differences in sequences from species to species may affect numbering. One of skill in the art will be able to identify the respective residue in any homologous protein and in the respective encoding nucleic acid by methods well known in the art, e.g., by sequence alignment and determination of homologous residues. Exemplary suitable diseases and disorders include, without limitation, cystic fibrosis (see, e.g., Schwank et al, Functional repair of CFTR by CRISPR/Cas9 in intestinal stem cell organoids of cystic fibrosis patients. Cell stem cell. 2013; 13 : 653-658; and Wu et. al., Correction of a genetic disease in mouse via use of CRISPR-Cas9. Cell stem cell. 2013; 13 : 659-662, neither of which uses a deaminase fusion protein to correct the genetic defect); phenylketonuria - e.g., phenylalanine to serine mutation at position 835 (mouse) or 240 (human) or a homologous residue in phenylalanine hydroxylase gene (T>C mutation) - see, e.g., McDonald et al, Genomics. 1997; 39:402-405; Bernard-Soulier syndrome (BSS) - e.g., phenylalanine to serine mutation at position 55 or a homologous residue, or cysteine to arginine at residue 24 or a homologous residue in the platelet membrane glycoprotein IX (T>C mutation) - see, e.g., Noris et al, British Journal of Haematology. 1997; 97: 312-320, and Ali et al. , Hematol. 2014; 93 : 381- 384; epidermolytic hyperkeratosis (EHK) - e.g., leucine to proline mutation at position 160 or 161 (if counting the initiator methionine) or a homologous residue in keratin 1 (T>C mutation) - see, e.g., Chipev et al, Cell. 1992; 70: 821-828, see also accession number P04264 in the UNIPROT database at www[dot]uniprot[dot]org; chronic obstructive pulmonary disease (COPD) - e.g., leucine to proline mutation at position 54 or 55 (if counting the initiator methionine) or a homologous residue in the processed form of α,ι- antitrypsin or residue 78 in the unprocessed form or a homologous residue (T>C mutation) - see, e.g., Poller et al, Genomics. 1993; 17: 740-743, see also accession number POlOl l in the UNIPROT database; Charcot-Marie-Toot disease type 4J - e.g., isoleucine to threonine mutation at position 41 or a homologous residue in FIG4 (T>C mutation) - see, e.g., Lenk et al., PLoS Genetics. 2011 ; 7: el002104; neuroblastoma (NB) - e.g., leucine to proline mutation at position 197 or a homologous residue in Caspase-9 (T>C mutation) - see, e.g., Kundu et al, 3 Biotech. 2013, 3:225-234; von Willebrand disease (vWD) - e.g., cysteine to arginine mutation at position 509 or a homologous residue in the processed form of von Willebrand factor, or at position 1272 or a homologous residue in the unprocessed form of von Willebrand factor (T>C mutation) - see, e.g., Lavergne et al, Br. J. Haematol. 1992, see also accession number P04275 in the UNIPROT database; 82: 66-72; myotonia congenital - e.g., cysteine to arginine mutation at position 277 or a homologous residue in the muscle chloride channel gene CLCN1 (T>C mutation) - see, e.g., Weinberger et al, The J. of Physiology. 2012; 590: 3449-3464; hereditary renal amyloidosis - e.g., stop codon to arginine mutation at position 78 or a homologous residue in the processed form of apolipoprotein All or at position 101 or a homologous residue in the unprocessed form (T>C mutation) - see, e.g., Yazaki et al, Kidney Int. 2003; 64: 11-16; dilated cardiomyopathy (DCM) - e.g., tryptophan to Arginine mutation at position 148 or a homologous residue in the FOXD4 gene (T>C mutation), see, e.g., Minoretti et. al., Int. J. ofMol. Med. 2007; 19: 369-372; hereditary lymphedema - e.g., histidine to arginine mutation at position 1035 or a homologous residue in VEGFR3 tyrosine kinase (A>G mutation), see, e.g., Irrthum et al, Am. J. Hum. Genet. 2000; 67: 295-301; familial Alzheimer's disease - e.g., isoleucine to valine mutation at position 143 or a homologous residue in presenilinl (A>G mutation), see, e.g., Gallo et. al., J. Alzheimer 's disease. 2011; 25: 425-431; Prion disease - e.g., methionine to valine mutation at position 129 or a homologous residue in prion protein (A>G mutation) - see, e.g., Lewis et. al., J. of General Virology. 2006; 87: 2443-2449; chronic infantile neurologic cutaneous articular syndrome (CINCA) - e.g., Tyrosine to Cysteine mutation at position 570 or a homologous residue in cryopyrin (A>G mutation) - see, e.g., Fujisawa et. al. Blood. 2007; 109: 2903-2911; and desmin-related myopathy (DRM) - e.g., arginine to glycine mutation at position 120 or a homologous residue in α,Β crystallin (A>G mutation) - see, e.g., Kumar et al, J. Biol. Chem. 1999; 274: 24137-24141. The entire contents of all references and database entries is incorporated herein by reference.

[00220] The instant disclosure provides lists of genes comprising pathogenic T>C or

A>G mutations, which may be corrected using any of the Cas9 fusion proteins provided herein. Provided herein, are the names of these genes, their respective SEQ ID NOs, their gene IDs, and sequences flanking the mutation site. See Tables 4 and 5. Without wishing to be bound by any particular theory, the mutations provided in Tables 4 and 5 may be corrected using the Cas9 fusions provided herein, which are able to bind to target sequences lacking the canonical PAM sequence. In some embodiments, a Cas9-deaminase fusion protein demostrates activity on non-canonical PAMs and therefore can correct all the pathogenic T>C or A>G mutations listed in Tables 4 and 5 (SEQ ID NOs: 674-2539 and 3144-5083), respectively. In some embodiments, a Cas9-deaminase fusion protein recognizes canonical PAMs and therefore can correct the pathogenic T>C or A>G mutations with canonical PAMs, e.g., 5'-NGG-3'. It should be appreciated that a skilled artisan would understand how to design an RNA {e.g., a gRNA) to target any of the Cas9 proteins or fusion proteins provided herein to any target sequence in order to correct any of the mutations provided herein, for example, the mutations provided in Tables 4 and 5. It will be apparent to those of skill in the art that in order to target a Cas9:effector domain fusion protein as disclosed herein to a target site, e.g., a site comprising a point mutation to be edited, it is typically necessary to co-express the Cas9:effector domain fusion protein together with a guide RNA, e.g., an sgRNA. As explained in more detail elsewhere herein, a guide RNA typically comprises a tracrRNA framework allowing for Cas9 binding, and a guide sequence, which confers sequence specificity to the Cas9:effector domain fusion protein. In some embodiments, the guide RNA comprises a structure 5 '-[guide sequence]- guuuuagagcuagaaauagcaaguuaaaauaaaggcuaguccguuaucaacuugaaaaaguggcaccgagucggugcuu uuu-3 ' (SEQ ID NO: 285),

wherein the guide sequence comprises a sequence that is complementary to the target sequence. The guide sequence is typically 20 nucleotides long. The sequences of suitable guide RNAs for targeting Cas9: effector domain fusion proteins to specific genomic target sites will be apparent to those of skill in the art based on the instant disclosure. Such suitable guide RNA sequences typically comprise guide sequences that are complementary to a nucleic sequence within 50 nucleotides upstream or downstream of the target nucleotide to be edited.

Kits, vectors, cells

[00221] Some aspects of this disclosure provide kits comprising a nucleic acid construct, comprising (a) a nucleotide sequence encoding a Cas9 protein or a Cas9 fusion protein as provided herein; and (b) a heterologous promoter that drives expression of the sequence of (a). In some embodiments, the kit further comprises an expression construct encoding a guide RNA backbone, wherein the construct comprises a cloning site positioned to allow the cloning of a nucleic acid sequence identical or complementary to a target sequence into the guide RNA backbone.

[00222] Some aspects of this disclosure provide polynucleotides encoding a Cas9 protein of a fusion protein as provided herein. Some aspects of this disclosure provide vectors comprising such polynucleotides. In some embodiments, the vector comprises a heterologous promoter driving expression of polynucleotide.

[00223] Some aspects of this disclosure provide cells comprising a Cas9 protein, a fusion protein, a nucleic acid molecule, and/or a vector as provided herein.

[00224] The description of exemplary embodiments of the reporter systems herein is provided for illustration purposes only and not meant to be limiting. Additional reporter systems, e.g., variations of the exemplary systems described in detail above, are also embraced by this disclosure.

EXAMPLES

EXAMPLE 1: PACE Evolution of a Cas9 Without PAM Sequence Restriction

[00225] Building PAM Libraries. Four different protospacer target sequences were synthesized: Doench 1 - 5 '- AAGAGAGAC AGT AC ATGCCC-3 '(SEQ ID NO: 286);

Doench 2 - 5'-GGAGCCCACCGAGTACCTGG-3 '(SEQ ID NO: 287); G7' - 5'- AGTCTCCTCAGC AAAACGAA-3 '(SEQ ID NO: 288); and VEGF Target 2 - 5'- GACCCCCTCCACCCCGCCTC-3 ' (SEQ ID NO: 289). For each protospacer target sequence, a 3'- NNN PAM library was built. While the canonical PAM sequence is 5 '-NOGS', {e.g., an exemplary [Doench Π-rcanonical PA Ml target sequence could be 5'- Γ AAGAGAGACAGTAC ATGCCCl-rNGGl-3 ' (SEQ ID NO: 291)), the 3 TSiNN PAM libraries for each protospacer target sequence contained a fully random PAM sequence, e.g., for Doenchl 5 '-AAGAGAGACAGTACATGCCCNNN-3 ' (SEQ ID NO: 290), wherein N represents any nucleotide. The NNN PAM libraries thus included every possible

combination of PAM sequences at the 3 ' end of the respective protospacer target sequence.

[00226] Testing the Activity of Cas9 on PAM Libraries in a co-dCas9 luciferase assay. Cas9 activity was tested using a bacterial luciferase activation assay in which a fusion protein of the ω subunit of Escherichia coli RNA polymerase (rpoZ) to dCas9 (see, e.g., Bikard et al., Nucleic Acids Res. 2013 Aug; 41(15): 7429-7437) drives the production of luciferase encoded by a nucleic acid under the control of a weak promoter comprising a sequence targeted by an sgRNA. Each PAM library was cloned into a plasmid comprising such a weak promoter, where the [target sequence] -[PAM library] nucleic acid sequences served as the sequence targeted by an sgRNA. A PAM library was cloned into the promoter for The co-dCas9 assay was run on all four protospacer targets for both the canonical PAM and the random PAM library. Figure 1 shows the activity of wild-type S. pyogenes Cas9 on PAM Libraries.

[00227] Evolution of Cas9 on PAM Libraries. S. pyogenes dCas9 was fused to the ω unit of RNA polymerase. The resulting co-dCas9 fusion protein was cloned into an M13 phage-based selection phagemid (SP), comprising the entire M13 phage genome except for a functional version of the gene encoding pill, a gene essential for the generation of infectious phage particles. The phage gene encoding pill was provided on a separate plasmid

(accessory plasmid, AP), under the control of a promoter that is transcriptionally activated by co-dCas9. The PAM library was cloned into the promoter region of the accessory plasmid. Host cells used for the directed evolution of Cas9 proteins without PAM restriction were provided that harbored the accessory plasmid. Upon infection with a selection phage, the amount of infectious phage particles produced by a given host cell thus depends on the activity of the co-dCas9 fusion protein encoded by the selection phage on the promoter of the accessory plasmid, which is required for the production of pill protein. The accessory plasmid thus confers a selective advantage to those selection phages encoding co-dCas9 fusion protein variants with an increased activity on different non-canonical PAM sequences.

[00228] A lagoon was provided and a flow of host cells comprising the accessory plasmid was generated through the lagoon. The host cells were contacted with the selection phagemid, resulting in a population of selection phage propagating in the flow of host cells in the lagoon. Phage-infected host cells were removed from the lagoon and fresh, uninfected host cells were fed into the lagoon at a rate resulting in the average time a host cell remained in the lagoon being shorter than the average time between cell division of the host cells, but longer than the average Ml 3 phage life cycle time.

[00229] In order to generate Cas9 variants during a directed evolution experiment, the host cells in the lagoon were incubated under conditions resulting in an increased mutation rate. The host cells were harboring a mutagenesis plasmid (MP), which increased the mutagenesis rate, thus introducing mutations in the co-dCas9 fusion protein encoded by the selection phagemid during the phage life cycle. Because the flow rate of host cells through the lagoon results in the average time a host cell remains in the lagoon being shorter than the average time between host cell divisions, the host cells in the lagoon cannot accumulate mutations resulting from the increased mutation rate conferred by the mutagenesis plasmid in their genome or on the accessory plasmid. The selection phage, however, replicate in the lagoon in the flow of host cells and thus accumulate mutations over time, resulting in the generation of new, evolved co-dCas9 fusion protein variants.

[00230] If any of these evolved co-dCas9 fusion protein variants includes a mutation that confers an increased activity on the accessory plasmid comprising the PAM library, this will directly translate into the generation of more pill by a host cell infected with a selection phage encoding the respective co-dCas9 fusion protein variant. The production of more pill will, in turn, result in the generation of more infectious selection phage particles, which, over time, results in a competitive advantage of the mutant selection phage harboring such beneficial mutations over selection phage not harboring such mutations. After a period of time, the selective pressure exerted by the accessory plasmid will, therefore, result in selection phage having acquired beneficial mutations being the predominant species replicating in the flow of host cells, while selection phage with no mutations or with detrimental mutations will be washed out of the lagoon.

[00231] Because the co-dCas9 fusion protein activity on the PAM library was very low at the beginning of the experiment, multiple rounds of overnight propagation of the selection phagemid in host cells harboring an accessory plasmid containing the PAM library were carried out to evolve Cas9 variants that show increased activity on noncanonical PAM sequences. At the end of a directed evolution experiment, the evolved population of selection phage was isolated from the lagoon, and a representative number of clones was analyzed to detect Cas9 variants having beneficial mutations. While all mutations observed confer a beneficial phenotype, mutations shared by more than one clone, or by all clones, are of particular interest. [00232] Mutations from Cas9 PACE. A number of selection phage clones was isolated from a directed evolution experiment using a PAM library accessory plasmid as described above. The mutations identified in the Cas9 amino acid sequence of some exemplary clones is provided below in Table l(residue numbering according to SEQ ID NO: 9):

Table 1 - Cas9 mutations identified in PACE (residue numbering according to SEQ ID NO: 9.

[00233] Clones 1-4 were tested in the co-dCas9 luciferase activation assay described above. When tested on the PAM library as a whole, the different clones showed an improvement in luciferase expression (Figure 2 - Cas9 activity of exemplary evolved clones on PAM library after directed evolution).

[00234] Improvement of Cas9 activity on non-canonical PAM sequences.

The activity of evolved Cas9 proteins on target sequences with noncanonical PAMs was evaluated in more detail. The relative activity of Clone 4, harboring 1122, D182, and E1219V mutations, for various [Doench 2 (5 '-GGAGCCC ACCGAGTACCTGG-3 ' (SEQ ID NO: 287))]-[PAM] target sequences was tested in the co-dCas9 luciferase activation assay and compared to the activity of wild-type dCas9.

[00235] Improvement of Cas9 activity on non-canonical PAM sequences.

The activity of evolved Cas9 proteins on target sequences with noncanonical PAMs was evaluated in more detail. The relative activity of Clone 4, harboring 1122, D182, and E1219V mutations, for various [Doench 2 (5 '-GGAGCCC ACCGAGTACCTGG-3 '(SEQ ID NO: 287))]-[PAM] target sequences was tested in the co-dCas9 luciferase activation assay and compared to the activity of wild-type dCas9. The data are shown in Table 2.

Clone 4 dCas9 Wild-type dCas9

PAM

Luciferase Activity Luciferase Activity

GTC 44.84 4.07

AGC 25.01 4.42 GAG 186.22 73.60

TTT 36.49 3.96

GTG 119.53 6.86

AGG 238.29 244.27

CAA 13.90 5.28

Table 2 - Relative activity of clone 4 on various PAM sequences.

EXAMPLE 2: PACE Evolution of a Cas9 Without Any PAM Sequence Restriction

[00236] Because the activity of the co-dCas9 fusion protein on the NNN-PAM libraries was very low, a second round of PACE experiments was performed, in which an initial phase of diversification of the co-dCas9 fusion protein population was carried out in the absence of selective pressure by providing a source of pill that did not depend on co-dCas9 fusion protein activity. The initial diversification stage allows mutations to develop that may not be accessible in a PACE experiment where selective pressure is applied throughout the experiment.

[00237] Selection phage harboring a co-dCas9 fusion protein with a dCas9 sequence provided as SEQ ID NO: 8 with D10A and H840A mutations was propagated overnight in 1030 host cells together with MP6 mutagenesis plasmid in the presence of arabinose in order to create a library of mutated selection phage encoding a library of co-dCas9 fusion protein variants. PHI was expressed from a separate plasmid in the host cells during this initial diversification stage. After overnight (12h) diversification, 1030 host cells harboring an accessory plasmid comprising an NNN PAM library cloned into a weak promoter as the guide RNA target sequence and a mutagenesis plasmid were grown to log phase, and used as the source of host cells to create a flow of host cells through a lagoon. The cells in the lagoon were infected with the diversified selection phage from the overnight incubation. The host cells in the lagoon were contacted with arabinose in order to maintain a high level of expression of the mutagenic genes from the mutagenesis plasmid.

[00238] The initial phage titers were about 10⁸ pfu/mL. A PACE experiment was performed for each of the four NNN-PAM libraries ([Doench 1]-[NNN-PAM], [Doench 2]- [NNN-PAM], [G7]-[NNN-PAM], and [VEGF target] -[NNN-PAM] cloned into an accessory plasmid driving pill expression from a weak promoter as described above. The phage titers were monitored during the PACE experiments. A slow drop in phage titers to 10⁴ pfu/mL was observed. The phage population was isolated from the lagoon at that point, and grown on 2208 host cells containing a separate source of pill (psp-driven pill). After this low- stringency propagation period, a 1 : 100 dilution of the supernatant was added to fresh host cells harboring the accessory plasmid as the only source of pill in a new lagoon, and the PACE experiments were continued. No drop in phage titers was observed after this low- stringency incubation in 2208 cells.

[00239] One exemplary PACE experiment that was run for 72 hours. After that period of time, 24 surviving clones were isolated from the lagoon, sequenced, and characterized. The mutations identified included A262T, K294R, S409I, M694I, E480K, E543D, and E1219V (amino acid numbering according to SEQ ID NO: 9). In another exemplary experiment, surviving clones were isolated after 15 days of incubation. Activity of the identified dVas9 mutants was characterized in a co-dCas9 luciferase assay. Clones with the best co-dCas9 fusion protein activity on noncanonical PAM target sequences had the following mutations: E480K, E543D, E1219V, and T1329.

[00240] Cas9 Mammalian GFP Activation. Both wild-type dCas9 (SEQ ID NO: 9) and the evolved Cas9 clones were tested in a dCas9-GFP assay in Hek293T cells. The cells were contacted with a reporter construct in which a GFP-encoding sequence was driven from a weak promoter that includes a [gRNA target sequence]-[PAM] sequence. Fusion proteins of dCas9 (wild-type and PACE variants) attached to the transcriptional activator VP64-p65- Rta (VPR) were generated, and the various dCas9-VPR variants were tested for their capacity to activate the GFP reporter in HEK293 cells.

[00241] Hek293T were transfected with four separate plasmids: a dCas9-VPR expression plasmid; a plasmid expressing the sgRNA targeting the gRNA target sequence of the GFP reporter plasmid; the GFP reporter plasmid; and an iRFP transfection control. In one experiment, the HEK293 cells were contacted with a GFP reporter included a TAA PAM, and in another experiment, the HEK293 cells were contacted with a population of reporter plasmids containing an NNN PAM library. Cells were harvested 48 hours after transfection and GFP expressing cells were quantified using a BD LSR- FORTESSA cell analyzer.

[00242] Figure 3 - Cas9 Mammalian GFP Activation. Compared with WT Cas9, the evolved Cas9s showed much higher activity on both the TAA PAM (21.08% vs. 0.60% of cells above negative control) and a library of NNN PAM (22.76% vs. 3.38% of cells above negative control).

[00243] Evolved Cas9 Cutting Activity on Target Sequences with noncanonical

PAM. In order to demonstrate that the PACE mutations universally confer Cas9 activity without PAM restriction, nuclease-active Cas9 proteins were generated based on the sequence provided in , i.e., without the D10A and H840A mutations, but harboring the various PACE mutations. The evolved Cas9 variants were tested in a Cas9 GFP assay, assessing the capacity of the evolved Cas9 protein variants to target and inactivate an emGFP gene integrated into the genome of HEK293 cells using a guide RNA targeting a sequence with a noncanonical PAM. It was observed that 6.45% of cells showed loss of GFP expression when contacted with a wild-type nuclease-active Cas9 (SEQ ID NO: 9), while 54.55% of cells contacted with the evolved Cas9 (E480K, E543D, E1219V, and T1329) showed a loss of GFP expression.

EXAMPLE 3: Cas9 variants without PAM Restrictions

[00244] The beneficial mutations conferring Cas9 activity on noncanonical PAM sequences were mapped to a S. pyogenes wild-type sequence. Below is an exemplary Cas9 sequence (S. pyogenes Cas9 with D10 and H840 residues marked with an asterisk following the respective amino acid residues, SEQ ID NO: 9). The D10 and H840 residues of SEQ ID NO: 9 may be mutated to generate a nuclease inactive Cas9 (e.g., to D10A and H840A) or to generate a nickase Cas9 (e.g., to D10A with H840; or to D10 with H840A). The HNH domain (bold and underlined) and the RuvC domain (boxed) are identified. The residues found mutated in the clones isolated from the various PACE experiments, amino acid residues 122, 137, 182, 262, 294, 409, 480, 543, 660, 694, 1219, and 1329 are identified with an asterisk following the respective amino acid residue.

MDKKYSIGLD*IGTNSVG AVITDEYKVPSKKFKVLGNTDRHSIKKNLIGALLFDSGETAEATRLKRTARRRYTR

RKNRICYLQEIFSNEMAKVDDSFFHRLEESFLVEEDKKHERHPIFGNI*VDEVAYHEKYPTIYH*LRKKLVDSTD

KADLRLIYLALAHMIKFRGHFLIEGDLNPDNSDVD*KLFIQLVQTYNQLFEENPINASGVDAKAILSARLSKSRR

LENLIAQLPGEKKNGLFGNLIALSLGLTPNFKSNFDLAEDA*KLQLSKDTYDDDLDNLLAQIGDQYADLFLAAK*

NLSDAILLSDILR TEITKAPLSASMIKRYDEHHQDLTLLKALVRQQLPEKYKEIFFDQSKNGYAGYIDGGASQ

EEFYKFIKPILEKMDGTEELLVKLNREDLLRKQRTFDNGS*IPHQIHLGELHAILRRQEDFYPFLKDNREKIEKI

LTFRIPYYVGPLARGNSRFAWMTRKSEETITPWNFEE*WDKGASAQSFIERMTNFDKNLPNEKVLPKHSLLYEY

FTVYNELTKVKYVTEGMRKPAFLSGE*QKKAIVDLLFKTNRKVTVKQLKEDYFKKIECFDSVEISGVEDRFNASL

GTYHDLLKIIKDKDFLDNEENEDILEDIVLTLTLFEDREMIEERLKTYAHLFDDKVMKQLKRRRYTGWG*RLSRK

LINGIRDKQSGKTILDFLKSDGFANRNFM*QLIHDDSLTFKEDIQKAQVSGQGDSLHEHIANLAGSPAIKKGILQ|

|TVKVVDELVKVMGRHKPENIVIEMA1RENQTTQ

YLQNGRDMYVDQELDI1SRRLSDYDVDH*IVPQSFLKDD^

AKLITQRKFDNLTKAERG|GLSELDKAGFIKRQLVETRQITKHVAQILDSRMNTKYDENDKLIREVKVITLKSKLV| |SDFRKDFQFYKVREINNYHHAHDAYLNAWGTALIKKYPKLESEFVYGDYKVYDVRKMIAKSEQEIGKATAKYFF| |YSNIMNFFKTEITLANGEIRKRPLIETNGETGEI DKGRDFATVRKVLSMPQ IVKKTEVQT|GGFSKESILPK RNSDKLIARKKDWDPKKYGGFDSPTVAYSVLWAKVEKGKSKKLKSVKELLGITIMERSSFEKNPIDFLEAKGYK EVKKDLIIKLPKYSLFELENGRKRMLASAGE*LQKGNELALPSKY FLYLASHYEKLKGSPEDNEQKQLFVEQH KHYLDEIIEQISEFSKRVILADANLDKVLSAYNKHRDKPIREQAENIIHLFTLTNLGAPAAFKYFDT*TIDRKRY TSTKEVLDATLIHQSITGLYETRIDLSQLGGD (SEQ ID NO : 9 )

[00245] The beneficial mutations conferring Cas9 activity on noncanonical PAM sequences were mapped to additional exemplary wild-type Cas9 sequences. The HNH domain (bold and underlined) and the RuvC domain (boxed) are identified. The residues homologous to the residues found mutated in SEQ ID NO: 9, amino acid residues 122, 137, 182, 262, 294, 409, 480, 543, 660, 694, 1219, and 1329 are identified with an asterisk following the respective amino acid residue. In addition, amino acid residues 10 and 840, which are mutated in dCas9 protein variants, are also identified by an asterisk.

297)

298)

>gi 504540549 ref _014727651.1 type -guided endonuclease Cas9 [Streptococcus thermophilus ] MTKPYSIGLD*IGTNSVG AVITDNYKVPSKK KVLGNTSKKYIKKNLLGVLLFDSGITAEGRRLKRTARRRYTR

RRNRILYLQEIFSTEMATLDDAFFQRLDDSFLVPDDKRDSKYPIFGNL*VEEKAYHDEFPTIYH*LRKYLADSTK KADLRLVYLALAHMIKYRGHFLIEGEFNSKNNDIQ*KNFQDFLDTYNAI FESDLSLENSKQLEEIVKDKISKLEK KDRILKLFPGEKNSGIFSEFLKLIVGNQADFRKCFNLDEKA*SLHFSKESYDEDLETLLGYIGDDYSDVFLKAK* KLYDAILLSGFLTVTDNETEAPLSSAMIKRYNEHKEDLALLKEYIRNISLKTYNEVFKDDTKNGYAGYIDGKTNQ EDFYVYLKNLLAEFEGADYFLEKIDREDFLRKQRTFDNGS*IPYQIHLQEMRAILDKQAKFYPFLAKNKERIEKI LTFRIPYYVGPLARGNSDFAWSIRKRNEKITPWNFED*VIDKESSAEAFINRMTSFDLYLPEEKVLPKHSLLYET FNVYNELTKVRFIAESMRDYQFLDSK*QKKDIVRLYFKDKRKVTDKDIIEYLHAIYGYDGIELKGIEKQFNSSLS TYHDLLNIINDKEFLDDSSNEAIIEEIIHTLTIFEDREMIKQRLSKFENIFDKSVLKKLSRRHYTGWG*KLSAKL INGIRDEKSGNTILDYLIDDGISNRNFM*QLIHDDALSFKKKIQKAQIIGDE|D^"KGNIKEWKSLPGSPAIKKGIL| |QSIKIVDELVKVMGGRKPESIWEMA|RENQYTNQGKSNSQQRLKRLEKSLKELGSKILKENIPAKLSKID NALQ ITORLYLYYLQNGKDMYTGDDLDIDRLSNYDIDH*IIPQAFLKDNSID-^VLVSSAS-^GKSDDFPSLEVVKKRKT FWYQLLKSKLISQRKFDNLTKAERG|GLLPEDKAGFIQRQLVETRQITKHVARLLDEKFNNKKDENNRAVRTVKII| |TLKSTLVSQFRKDFELYKVREINDFHHAHDAYLNAVIASALLKKYPKLEPEFVYGDYPKYNSFRERKSATEKVYF| |YSNIMNIFKKSISLADGRVIERPLIE EETGESVWNKESDLATVRRVLSYPQ WKKVEEQN|HGLDRGKPKGL FNANLSSKPKPNSNENLVGAKEYLDPKKYGGYAGISNSFAVLVKGTIEKGAKKKITNVLEFQGISILDRINYRKD KLNFLLEKGYKDIELIIELPKYSLFELSDGSRRMLASILSTNNKRGE*IHKGNQIFLSQKFVKLLYHAKRISNTI NENHRKYVENHKKEFEELFYYILEFNENYVGAKKNGKLLNSAFQSWQNHSIDELCSSFIGPTGSERKGLFELTSR GSAADFEFLGV*KIPRYRDYTPSSLLKDATLIHQSVTGLYETRIDLAKLGEG (SEQ ID NO: 260)

>gi 924443546 | Staphylococcus Aureus Cas9

GSHMKRNYILGLD*IGITSVGYGIIDYETRDVIDAGVRLFKEA VENNEGRRSKRGARRLKRRRRHRIQRVKKLL

FDYNLLTDHSELSGINP*YEARVKGLSQKLSEEEFSAALLHLAKRRGVHN EVEEDTGNELST*KEQISRNSKA LEEKYVAELQLERLKKDGEVRGSINRFKTSDYVKEAKQLLKVQKAYHQLDQSFIDTYIDLLETRRTYYEGPGEGS PFGWKDIKEWYEMLMGHCTYFPEELRSVKYAYNADLYNALNDLNNLVITRDENEKLEYY*EKFQIIENVFKQKKK PTLKQIAKEIL EEDIKGYRVTSTGKPEFTNLKVYHDIKDITARKEIIENAELLDQIAKILTIYQSSEDIQEEL TNLNSELTQEEIEQISNLKGYTGTH*NLSLKAINLILDELWHTNDNQIAI FNRL*KLVPKKVDLSQQK|EIPTTLV| |DDFILSPWKRSFIQSIKVINAIIKKYGLPNDIIIELA|REKNSKDAQKMINEMQKRNRQT ERIEEIIRTTGKEN AKYLIEKIKLHDMQEGKCLYSLEAIPLEDLLITOPFNYEVDH*IIPRSVSFDNSF KVLVKQEEASKKG RTPFQ YLSSSDSKISYETFKKHILNLAKGKGRISKTKKE|YLLEERDINRFSVQKDFINRNLVDTRYATRGLMNLLRSYFR| |WNLDVKVKSINGGFTSFLRRKWKFKKERNKGYKHHAEDALIIANADFIFKEWKKLDKAKKVMENQMFEEKQAES| |MPEIETEQEYKEIFITPHQIKHIKDFKDYKYSHRVDKKPNRELINDTLYST|RKDDKGNTLI NLNGLYDKDNDK LKKLINKSPEKLLMYHHDPQTYQKLKLIMEQYGDEKNPLYKYYEETGNYLTKYSKKDNGPVIKKIKYYGNKLNAH LDITDDYPNS*RNKWKLSLKPYRFDVYLDNGVYKFVTVKNLDVIKKENYYE SKAYEEAKKLKKISNQAEFIA SFYNNDLIKINGELYRVIG NDLLNRIE MIDITYREYLEN*MNDKRPPRIIKTIASKTQSIKKYSTDILGNL YEVKSKKHPQIIKKG (SEQ ID NO: 261)

[00246] This disclosure provides Cas9 variants in which one or more of the amino acid residues identified by an asterisk are mutated as described herein. In some embodiments, the D10 and H840 residues are mutated, e.g., to an alanine residue, and the Cas9 variants provided include one or more additional mutations of the amino acid residues identified by an asterisk as provided herein. In some embodiments, the D10 residue is mutated, e.g., to an alanine residue, and the Cas9 variants provided include one or more additional mutations of the amino acid residues identified by an asterisk as provided herein.

[00247] A number of Cas9 sequences from various species were aligned to determine whether corresponding homologous amino acid residues can be identified in other Cas9 proteins, allowing the generation of Cas9 variants with corresponding mutations of the homologous amino acid residues. The alignment was carried out using the NCBI Constraint- based Multiple Alignment Tool (COBALT(accessible at st-va.ncbi. nlm.nih.gov/tools/cobalt), with the following parameters. Alignment parameters: Gap penalties -11,-1; End-Gap penalties -5,-1. CDD Parameters: Use RPS BLAST on; Blast E-value 0.003; Find Conserved columns and Recompute on. Query Clustering Parameters: Use query clusters on; Word Size 4; Max cluster distance 0.8; Alphabet Regular.

[00248] An exemplary alignment of four Cas9 sequences is provided below. The Cas9 sequences in the alignment are: Sequence 1 (SI): SEQ ID NO: 10 | WP_010922251 | gi 499224711 | type II CRISPR RNA-guided endonuclease Cas9 [Streptococcus pyogenes]; Sequence 2 (S2): SEQ ID NO: 11 | WP_039695303 | gi 746743737 | type II CRISPR RNA- guided endonuclease Cas9 [Streptococcus gallolyticus]; Sequence 3 (S3): SEQ ID NO: 12 | WP_045635197 | gi 782887988 | type II CRISPR RNA-guided endonuclease Cas9

[Streptococcus mitis]; Sequence 4 (S4): SEQ ID NO: 13 | 5AXW_A | gi 924443546 | Staphylococcus Aureus Cas9. The HNH domain (bold and underlined) and the RuvC domain (boxed) are identified for each of the four sequences. Amino acid residues 10, 122, 137, 182, 262, 294, 409, 480, 543, 660, 694, 840, 1219, and 1329 in SI and the homologous amino acids in the aligned sequences are identified with an asterisk following the respective amino acid residue.

51 1 —MDKK-YSIGLD*IGT SVGWAVITDEYKVPSKKFKVLGNTDRHSIKKHLI—GALLFDSG—ETAEATRLKRTARRRYT 73

52 1 —MTKKNYSIGLD*IGT SVGWAVITDDYKVPAKK KVLGNTDKKYIKKNLL—GALLFDSG—ETAEATRLKRTARRRYT 74

53 1 —Μ-ΚΚ0Υ3Ι0ίΡ*Ι0Τ 3ν0ΓΑνΐΤΡΡΥΚνΡ3ΚΚίΙΚνί0 ΤΡΚΚΓΙΚΚΗίΙ—GALLFDEG—TTAEARRLKRTARRRYT 73

54 1 GSHMKRNYILGLP*IGITSVGYGII—PYET RPVIPAGVRLFKEA VENNEGRRSKRGARRLKR 61

51 74 RRKNRICYLQEIFSNEMAKVDDSFFHRLEESFLVEEDKKHERHPIFGNI*VDEVAYHEKYPTIYH*LRKKLVDSTDKADLRL 153

52 75 RRKNRLRYLQEIFA EIAKVDESFFQRLDESFLTDDDKTFDSHPIFGNK*AEEDAYHQKFPTIYH*LRKHLADSSEKADLRL 154

53 74 RRKNRLRYLQEIFSEEMSKVDSSFFHRLDDSFLIPEDKRESKYPIFATL*TEEKEYHKQFPTIYH*LRKQLADSKEKTDLRL 153

54 62 RRRHRIQRVKKLL FDYNLLTD HSELSGINP*YEARVKGLSQKLSEEE 107

51 154 IYLALAHMIKFRGHFLIEGDLNPDNSDVD*KLFIQLVQTYNQLFEENPINASGVDAKAILSARLSKSRRLENLIAQLPGEK 233

52 155 VYLALAHMIKFRGHFLIEGELNAENTDVQ*KIFADFVGVYNRTFDDSHLSEITVDVASILTEKISKSRRLENLIKYYPTEK 234

53 154 IYLALAHMIKYRGHFLYEEAFDIKNNDIQ^KIFNEFISIYDNTFEGSSLSGQNAQVEAIFTDKISKSAKRERVLKLFPDEK 233

54 108 FSAALLHLAKRRG VHN EVEEDT 131

51 234 KNGLFGNLIALSLGLTPNFKSNFDLAEDA*KLQLSKDTYDDDLDNLLAQIGDQYADLFLAAK*NLSDAILLSDILRWTEIT 313

52 235 KNTLFGNLIALALGLQPNFKTNFKLSEDA*KLQFSKDTYEEDLEELLGKIGDDYADLFTSAK*NLYDAILLSGILTVDDNST 314

53 234 STGLFSEFLKLIVGNQADFKKHFDLEDKA*PLQFSKDTYDEDLENLLGQIGDDFTDLFVSAK*KLYDAILLSGILTVTDPST 313

54 132 GNELS T*KEQISRN 144

51 314 KAPLSASMIKRYDEHHQDLTLLKALVRQQLPEKYKEIFFDQSKNGYAGYIDGGASQEEFYKFIKPILEKM—DGTEELLV 391

52 315 KAPLSASMIKRYVEHHEDLEKLKEFIKANKSELYHDIFKDKNKNGYAGYIENGVKQDEFYKYLKNILSKIKIDGSDYFLD 394 S3 314 KAPLSASMIERYENHQNDLAALKQFIKNNLPEKYDEVFSDQSKDGYAGYIDGKTTQE FYKYIKNLLSKF—EGTDYFLD 391

S4 145 SKALEEKYVAELQ LERLKKDG 165

SI 392

S2 395

S3 392

S4 166 —EVRGSINRFKTSD- -YVKEAKQLLKVQKAYHQLDQSFIDTYIDLLETRRTYYEGP—GEGSPFGW- -K 227

SI 472

S2 475

S3 472

S4 228 <EW- YEMLMGHCTYFPEELRSVKYAYNADLYNALNDLNNLVI RDENEK LEYY*EKFQIIEN 289

SSII 555522 LFKTNRKVTVKQLKEDYFKKIECFDSVEISGVEDR FNASLGTYHDLLKIIKDKDFLDNEENEDILEDIVLTLTLFED 628

S2 554 VFKENRKVTKEKLLNYLNKEFPEYRIKDLIGLDKENKSFNASLGTYHDLKKIL-DKAFLDDK EEVIEDIIKTLTLFED 632

S3 552

S4 290 -ENAELLDQIAKIL IYQS 363

SI 629

S2 633

S3 628

S4 364 -LWHTNDNQIAIFNRL^KLVP 428

SI 708 QKGQKNSRER 781

S2 712 NRGRSQSQQRL 784

S3 707 ARGKKNSQQRY 779

SS44 442299 -KKVDLSQQK|EIPTTLVDDFILSPWKRSFIQSIKVINAIIKKYG—LPNDIIIELA|REKNSKDAQKMINEMQKR RQT 505

SI 782 -KEHPVENTQLQNEKLYLYYLQNGRDMYVDQELDINRLSD- -YDVDH*IVPQSFLKDD 850

S2 785 KKLQNSLKELGSNIL EEKPSYIEDKVENSHLQ DQLFLYYIQNGKDMYTGDELDIDHLSD- -YDIDH*IIPQAFIKDD 860

S3 780 [EDSLKILASGL DSNILKENPTD QLQ DRLFLYYLQNGKDMYTGEALDINQLSS- -YDIDH*IIPQAFIKDD 852

S4 506 -ENAKYLIEKIKLHDMQEGKCLYSLEAIPLEDLLN PF YEVDH*IIPRSVSFDN 570

SI 851 SID KVLTRSDKNRGKSDI PSEEVVKK KNYWRQLLNAKLITQRKFDN-LTKAERGlGL-SELD- -KAGFIKRQLV| 922

S2 8611 SID RVLTSSA NRGKSDDVPSLDIVRARKAEWVRLYKSGLISKRKFDN-LTKAERGGL-TEAD- -KAGFIKRQLV| 932

S3 853 SLD RVLTSSKD RGKSD VPSIEWQKRKAFWQQLLDSKLISERKF -LTKAERG|GL-DERD- -KVGFIKRQLV| 924

SS44 557711 SFNNKVLVKOEEASKKGNRTPFQYLSSSDSKISYETFKKHILNLAKGKGRISKTKKE|YLLEERDINRFSVQKDFINRNLA/| 650

SI 923 ETRQI KHVAQILDSRMNTKYDENDKLIREVKVI LKSKLVSDFRKDFQFYKVREINNYHHAHDAYLNAWGTALIKKYP| 1002

S2 933 ETRQI KHVAQILDARFNTEHDENDKVIRDVKVI LKSNLVSQFRKDFEFYKVREINDYHHAHDAYLNAWGTALLKKYP 1012

S3 925 ETRQI KHVAQILDARYNTE EKDKKNRTVKII LKSNLVSNFRKEFRLYKVREINDYHHAHDAYLNAWAKAILKKYP 1004

S4 651 DTRYATRGLMNLLRSYFR - -NLDVKVKSINGGFTSFLRRKWKFKKERNKGYKHHAEDALIIA- 712

SI 1003 KLESEFVYGDYKVYDVRKMIAKSEQ—EIGKATAKYFFYSNIMNFFKTEI LANGEIRKRPLIETNGETGEIVWDKG- 1077

S2 1013 KLASEFVYGEYKKYDIRKFI NSSD KATAKYFFYSNLMNFFKTKVKYADGTVFERPIIETNAD-GEIAWNKQ 1083

S3 1005 KLEPEFVYGEYQKYDLKRYISRSKDPKEVEKATEKYFFYSNLLNFFKEEVHYADG IVKRENIEYSKDTGEIAWNKE- 1081

S4 713 -NADFIFKEWKKLDKAKKVMENQM- -FEEKQAESMPEIETEQEYKEIFITPHQIK 764

SSII 11007788 I RDFATVRKVLSMPQWIVKKTEVQT|GGFSKESILPKRNSDKLIARKKD WDPKKYGGFDSPTVAYSVLWAKV 1149 52 1084 I IDFEKVRKVLSYPQWIVKKVETQT|GGFSKESILPKGDSDKLIPRKTKKVYWDTKKYGGFDSPTVAYSVFWADV 1158

53 1082 I KDFAIIKKVLSLPQVNIVKKREVQT|GGFSKESILPKGNSDKLIPRKTKDILLDTTKYGGFDSPVIAYSILLIADI 1156

54 765 |HIKDFKDYKYSHRVDKKPNRELINDTLYST|RKDDKGNTLIVNNLNGLYDKDNDKL KKLIN-KSP EKLLMYHH 835

51 1150 EKGKSKKLKSVKELLGI IMERSSFEKNPI-DFLEAKG YKEVKKDLIIKLPKYSLFELENGRKRMLASAGE*LQKG 1223

52 1159 EKGKAKKLKTVKELVGISIMERSFFEENPV-EFLENKG YHNIREDKLIKLPKYSLFEFEGGRRRLLASASE*LQKG 1232

53 1157 EKGKAKKLKTVKTLVGI IMEKAAFEENPI-TFLENKG YHNVRKENILCLPKYSLFELENGRRRLLASAKE*LQKG 1230

54 836 DPQTYQKLK LIMEQYGDEKNPLYKYYEETGNYLTKYSKKDNGPVIKKIKYYGNKLNAHLDITDDYPNS*RNKV 907

51 1224 NELALPSKY FLYLASHYEKLKGSPEDNEQKQLFVEQHKHYLDEIIEQISEFSKRVILADANLDKVLSAYNKH 1297

52 1233 NEMVLPGYLVELLYHAHRADNF NS EYLNYVSEHKKEFEKVLSCVEDFANLYVDVEKNLSKIRAVADSM 1301

53 1231 NEIVLPVYLTTLLYHSKNVHKL DEPGHLEYIQKHRNEFKDLLNLVSEFSQKYVLADANLEKIKSLYADN 1299

54 908 VKLSLKPYRFD-VYLDNGVYKFV TVKNLDVIK—KENYYE SKAYEEAKKLKKISNQAEFIASFYNNDLIKING 979

51 1298 RDKPIREQAENIIHLFTLTNLGAPAAFKYFDT*TIDRKRYTSTKEVLDATLIHQSIT GLYETRI DLSQL 1365

52 1302 DNFSIEEISNSFINLLTLTALGAPADFNFLGE*KIPRKRYTSTKECLNATLIHQSIT GLYETRI DLSKL 1369

53 1300 EQADIEILA SFINLLTFTALGAPAAFKFFGK*DIDRKRYTTVSEILNATLIHQSIT GLYETWI DLSKL 1367

54 980 ELYRVIGVNNDLLNRIEVNMIDITYR-EYLEN*MNDKRPPRIIKTIASKT QSIKKYSTDILGNLYEVKSKKHPQIIKK 1055

SI 1366 GGD 1368

S2 1370 GEE 1372

S3 1368 GED 1370

S4 1056 G— 1056

[00249] The alignment demonstrates that amino acid sequences and amino acid residues that are homologous to a reference Cas9 amino acid sequence or amino acid residue can be identified across Cas9 sequence variants, including, but not limited to Cas9 sequences from different species, by identifying the amino acid sequence or residue that aligns with the reference sequence or the reference residue using alignment programs and algorithms known in the art. This disclosure provides Cas9 variants in which one or more of the amino acid residues identified by an asterisk in SEQ ID NO: 9 are mutated as described herein. The residues in Cas9 sequences other than SEQ ID NO: 9 that correspond to the residues identified in SEQ ID NO: 9 by an asterisk are referred to herein as "homologous" or

"corresponding" residues. Such homologous residues can be identified by sequence alignment, e.g., as described above, and by identifying the sequence or residue that aligns with the reference sequence or residue. Similarly, mutations in Cas9 sequences other than SEQ ID NO: 9 that correspond to mutations identified in SEQ ID NO: 9 herein, e.g., mutations of residues 10, 122, 137, 182, 262, 294, 409, 480, 543, 660, 694, 840, 1219, and 1329 in SEQ ID NO: 9, are referred to herein as "homologous" or "corresponding" mutations. For example, the mutations corresponding to the D10A mutation in SI for the four aligned sequences above are D10A for S2, D9A for S3, and D13A for S4; the corresponding mutations for H840A in SI are H850A for S2, H842A for S3, and H560 for S4; the corresponding mutation for X1219V in SI are X1228V for S2, X1226 for S3, and X903 V for S4, and so on.

[00250] A total of 250 Cas9 sequences (SEQ ID NOs: 10-262) from different species were aligned using the same algorithm and alignment parameters outlined above. Amino acid residues homologous to residues 10, 122, 137, 182, 262, 294, 409, 480, 543, 660, 694, 840, 1219, and 1329 were identified in the same manner as outlined above. The alignments are provided below. The HNH domain (bold and underlined) and the RuvC domain (boxed) are identified for each of the four sequences. Residues corresponding to amino acid residues 10, 122, 137, 182, 262, 294, 409, 480, 543, 660, 694, 840, 1219, and 1329 in SEQ ID NO: 9 are boxed in SEQ ID NO: 10 in the alignments, allowing for the identification of the corresponding amino acid residues in the aligned sequences.

[00251] Cas9 variants with one or more mutations in amino acid residues homologous to amino acid residues 122, 137, 182, 262, 294, 409, 480, 543, 660, 694, 1219, and 1329 of SEQ ID NO: 9 are provided herein. In some embodiments, the Cas9 variants provided herein comprise mutations corresponding to the D10A and the H840A mutations in SEQ ID NO: 9, resulting in a nuclease-inactive dCas9, and at least one, at least two, at least three, at least four, at least five, at least six, or at least seven mutations of amino acid residues homologous to amino acid residues 122, 137, 182, 262, 294, 409, 480, 543, 660, 694, 1219, and 1329 of SEQ ID NO: 9.

[00252] Cas9 variants with one or more mutations in amino acid residues homologous to amino acid residues 122, 137, 182, 262, 294, 409, 480, 543, 660, 694, 1219, and 1329 of SEQ ID NO: 9 are provided herein. In some embodiments, the Cas9 variants provided herein comprise mutations corresponding to the D10A mutations in SEQ ID NO: 9, resulting in a partially nuclease-inactive dCas9, wherein the Cas9 can nick the non-target strand but not the targeted strand, and at least one, at least two, at least three, at least four, at least five, at least six, or at least seven mutations of amino acid residues homologous to amino acid residues 122, 137, 182, 262, 294, 409, 480, 543, 660, 694, 1219, and 1329 of SEQ ID NO: 9. WP_010922251.1 type II CRISPR RNA- guided endonuclease Cas9 [ Streptococcus pyogenes ] SEQ ID NO: 10 WP_039695303.1 type II CRISPR RNA- guided endonuclease Cas9 [Streptococcus gallolyticus ] SEQ ID NO WP_045635197.1 type II CRISPR RNA- guided endonuclease Cas9 [Streptococcus mitis] SEQ ID NO : 12 5AXW_A Cas9, Chain A, Crystal Structure [Staphylococcus Aureus] SEQ ID NO: 13

WP_009880683.1 type II CRISPR RNA- guided endonuclease Cas9 [ Streptococcus pyogenes ] SEQ ID NO: 14 WP_010922251.1 type II CRISPR RNA- guided endonuclease Cas9 [ Streptococcus pyogenes ] SEQ ID NO: 15 WP_011054416.1 type II CRISPR RNA- guided endonuclease Cas9 [ Streptococcus pyogenes ] SEQ ID NO: 16 WP_011284745.1 type II CRISPR RNA- guided endonuclease Cas9 [ Streptococcus pyogenes ] SEQ ID NO: 17 WP_011285506.1 type II CRISPR RNA- guided endonuclease Cas9 [ Streptococcus pyogenes ] SEQ ID NO: 18 WP_011527619.1 type II CRISPR RNA- guided endonuclease Cas9 [ Streptococcus pyogenes ] SEQ ID NO: 19 WP_012560673.1 type II CRISPR RNA- guided endonuclease Cas9 [ Streptococcus pyogenes ] SEQ ID NO: 20 WP_014407541.1 type II CRISPR RNA- guided endonuclease Cas9 [ Streptococcus pyogenes ] SEQ ID NO: 21 WP_020905136.1 type II CRISPR RNA- guided endonuclease Cas9 [ Streptococcus pyogenes ] SEQ ID NO: 22 WP_023080005.1 type II CRISPR RNA- guided endonuclease Cas9 [ Streptococcus pyogenes ] SEQ ID NO: 23 WP_023610282.1 type II CRISPR RNA- guided endonuclease Cas9 [Streptococcus pyogenes ] SEQ ID NO: 24 WP_030125963.1 type II CRISPR RNA- guided endonuclease Cas9 [Streptococcus pyogenes ] SEQ ID NO: 25 WP_030126706.1 type II CRISPR RNA- guided endonuclease Cas9 [Streptococcus pyogenes ] SEQ ID NO: 26 WP_031488318.1 type II CRISPR RNA- guided endonuclease Cas9 [ Streptococcus pyogenes ] SEQ ID NO: 27 WP_032460140.1 type II CRISPR RNA- guided endonuclease Cas9 [ Streptococcus pyogenes ] SEQ ID NO: 28 WP_032461047.1 type II CRISPR RNA- guided endonuclease Cas9 [ Streptococcus pyogenes ] SEQ ID NO: 29 WP_032462016.1 type II CRISPR RNA- guided endonuclease Cas9 [ Streptococcus pyogenes ] SEQ ID NO: 30 WP_032462936.1 type II CRISPR RNA- guided endonuclease Cas9 [ Streptococcus pyogenes ] SEQ ID NO: 31 WP_032464890.1 type II CRISPR RNA- guided endonuclease Cas9 [ Streptococcus pyogenes ] SEQ ID NO: 32 WP_033888930.1 type II CRISPR RNA- guided endonuclease Cas9 [ Streptococcus pyogenes ] SEQ ID NO: 33 WP_038431314.1 type II CRISPR RNA- guided endonuclease Cas9 [ Streptococcus pyogenes ] SEQ ID NO: 34 WP_038432938.1 type II CRISPR RNA- guided endonuclease Cas9 [ Streptococcus pyogenes ] SEQ ID NO: 35 WP_038434062.1 type II CRISPR RNA- guided endonuclease Cas9 [Streptococcus pyogenes ] SEQ ID NO: 36 BAQ51233.1 CRISPR-associated protein, Csnl family [Streptococcus pyogenes] SEQ ID NO: 37 KGE60162.1 hypothetical protein MGAS2111_0903 [Streptococcus pyogenes MGAS2111] SEQ ID NO: 3 KGE60856.1 CRISPR-associated endonuclease protein [Streptococcus pyogenes SS1447] SEQ ID NO: 39 WP_002989955.1 MULTISPECIES type II CRISPR RNA-guided endonuclease Cas9 [Streptococcus] SEQ ID NO WP_003030002.1 MULTISPECIES type II CRISPR RNA-guided endonuclease Cas9 [Streptococcus] SEQ ID NO WP_003065552.1 MULTISPECIES type II CRISPR RNA-guided endonuclease Cas9 [Streptococcus] SEQ ID NO WP_001040076.1 type II CRISPR RNA-guided endonuclease Cas9 [ Streptococcus agalactiae] SEQ ID NO 43 WP_001040078.1 type II CRISPR RNA-guided endonuclease Cas9 [ Streptococcus agalactiae] SEQ ID NO 44 WP_001040080.1 type II CRISPR RNA-guided endonuclease Cas9 [ Streptococcus agalactiae] SEQ ID NO 45 WP_001040081.1 type II CRISPR RNA-guided endonuclease Cas9 [ Streptococcus agalactiae] SEQ ID NO 46 WP_001040083.1 type II CRISPR RNA-guided endonuclease Cas9 [ Streptococcus agalactiae] SEQ ID NO 47 WP 001040085.1 type II CRISPR RNA-guided endonuclease Cas9 [Streptococcus agalactiae] SEQ ID NO

WP 001040087 1 type II CRISPR RNA- guided endonuclease Cas9 [ Streptococcus agalactiae] SEQ ID NO: 49

WP 001040088 1 type II CRISPR RNA- guided endonuclease Cas9 [ Streptococcus agalactiae] SEQ ID NO: 50

WP 001040089 1 type II CRISPR RNA- guided endonuclease Cas9 [ Streptococcus agalactiae] SEQ ID NO: 51

WP 001040090 1 type II CRISPR RNA- guided endonuclease Cas9 [ Streptococcus agalactiae] SEQ ID NO: 52

WP 001040091 1 type II CRISPR RNA- guided endonuclease Cas9 [ Streptococcus agalactiae] SEQ ID NO: 53

WP 001040092 1 type II CRISPR RNA- guided endonuclease Cas9 [ Streptococcus agalactiae] SEQ ID NO: 54

WP 001040094 1 type II CRISPR RNA- guided endonuclease Cas9 [ Streptococcus agalactiae] SEQ ID NO: 55

WP 001040095 1 type II CRISPR RNA- guided endonuclease Cas9 [ Streptococcus agalactiae] SEQ ID NO: 56

WP 001040096 1 type II CRISPR RNA- guided endonuclease Cas9 [Streptococcus agalactiae] SEQ ID NO: 57

WP ^"001040097 1 type II CRISPR RNA- guided endonuclease Cas9 [Streptococcus agalactiae] SEQ ID NO 58

WP ^"001040098 1 type II CRISPR RNA- guided endonuclease Cas9 [ Streptococcus agalactiae] SEQ ID NO 59

WP ^"001040099 1 type II CRISPR RNA- guided endonuclease Cas9 [ Streptococcus agalactiae] SEQ ID NO 60

WP ^"001040100 1 type II CRISPR RNA- guided endonuclease Cas9 [ Streptococcus agalactiae] SEQ ID NO 61

WP ^"001040104 1 type II CRISPR RNA- guided endonuclease Cas9 [ Streptococcus agalactiae] SEQ ID NO 62

WP ^"001040105 1 type II CRISPR RNA- guided endonuclease Cas9 [ Streptococcus agalactiae] SEQ ID NO 63

WP ^"001040106 1 type II CRISPR RNA- guided endonuclease Cas9 [ Streptococcus agalactiae] SEQ ID NO 64

WP ^"001040107 1 type II CRISPR RNA- guided endonuclease Cas9 [ Streptococcus agalactiae] SEQ ID NO 65

WP ^"001040108 1 type II CRISPR RNA- guided endonuclease Cas9 [ Streptococcus agalactiae] SEQ ID NO 66

WP ^"001040109 1 type II CRISPR RNA- guided endonuclease Cas9 [ Streptococcus agalactiae] SEQ ID NO 67

WP ^"001040110 1 type II CRISPR RNA- guided endonuclease Cas9 [Streptococcus agalactiae] SEQ ID NO 68

WP ^"015058523 1 type II CRISPR RNA- guided endonuclease Cas9 [Streptococcus agalactiae] SEQ ID NO 69

WP ^"017643650 1 type II CRISPR RNA- guided endonuclease Cas9 [ Streptococcus agalactiae] SEQ ID NO 70

WP ^"017647151 1 type II CRISPR RNA- guided endonuclease Cas9 [ Streptococcus agalactiae] SEQ ID NO 71

WP ^"017648376 1 type II CRISPR RNA- guided endonuclease Cas9 [ Streptococcus agalactiae] SEQ ID NO 72

WP ^"017649527 1 type II CRISPR RNA- guided endonuclease Cas9 [ Streptococcus agalactiae] SEQ ID NO 73

WP ^"017771611 1 type II CRISPR RNA- guided endonuclease Cas9 [ Streptococcus agalactiae] SEQ ID NO 74

WP ^"017771984 1 type II CRISPR RNA- guided endonuclease Cas9 [ Streptococcus agalactiae] SEQ ID NO 75

CFQ25032.1 CRISPR-associated protein [Streptococcus agalactiae] SEQ ID NO: 76

CFV16040.1 CRISPR-associated protein [Streptococcus agalactiae] SEQ ID NO: 77

KLJ37842.1 CRISPR-associated protein Csnl [Streptococcus agalactiae] SEQ ID NO: 78

KLJ72361.1 CRISPR-associated protein Csnl [Streptococcus agalactiae] SEQ ID NO: 79

KLL20707.1 CRISPR-associated protein Csnl [Streptococcus agalactiae] SEQ ID NO: 80

KLL42645.1 CRISPR-associated protein Csnl [Streptococcus agalactiae] SEQ ID NO: 81

WP 047207273 1 type II CRISPR RNA- guided endonuclease Cas9 [ Streptococcus agalactiae] SEQ ID NO 82

WP ^"047209694 1 type II CRISPR RNA- guided endonuclease Cas9 [ Streptococcus agalactiae] SEQ ID NO 83

WP ^"050198062 1 type II CRISPR RNA- guided endonuclease Cas9 [ Streptococcus agalactiae] SEQ ID NO 84

WP ^"050201642 1 type II CRISPR RNA- guided endonuclease Cas9 [ Streptococcus agalactiae] SEQ ID NO 85

WP ^"050204027 1 type II CRISPR RNA- guided endonuclease Cas9 [ Streptococcus agalactiae] SEQ ID NO 86

WP ^"050881965 1 type II CRISPR RNA- guided endonuclease Cas9 [ Streptococcus agalactiae] SEQ ID NO 87

WP_050886065.1 type II CRISPR RNA-guided endonuclease Cas9 [Streptococcus agalactiae] SEQ ID NO

AHN30376.1 CRISPR-associated protein Csnl [Streptococcus agalactiae 138P] SEQ ID NO: 89

EA078426.1 reticulocyte binding protein [Streptococcus agalactiae H36B] SEQ ID NO: 90

CCW42055.1 CRISPR-associated protein, SAG0894 family [Streptococcus agalactiae ILRI112] SEQ ID NO: 91 WP_003041502.1 type II CRISPR RNA-guided endonuclease Cas9 Streptococcus anginosus] SEQ ID NO 92 WP_037593752.1 type II CRISPR RNA-guided endonuclease Cas9 Streptococcus anginosus] SEQ ID NO 93 WP_049516684.1 CRISPR-associated protein Csnl [Streptococcus anginosus] SEQ ID NO: 94

GAD46167.1 hypothetical protein ANG6_0662 [Streptococcus anginosus T5] SEQ ID NO: 95

WP_018363470.1 type II CRISPR RNA-guided endonuclease Cas9 Streptococcus caballi] SEQ ID NO: 96 WP_003043819.1 type II CRISPR RNA- ^■guided endonuclease Cas9 Streptococcus canis] SEQ ID NO: 97

WP_006269658.1 type II CRISPR RNA- ^■guided endonuclease Cas9 Streptococcus constellatus] SEQ ID NO 98 WP_048800889.1 type II CRISPR RNA- ^■guided endonuclease Cas9 Streptococcus constellatus] SEQ ID NO 99 WP_012767106.1 type II CRISPR RNA- ^■guided endonuclease Cas9 Streptococcus dysgalactiae] SEQ ID NO 100 WP_014612333.1 type II CRISPR RNA- ^■guided endonuclease Cas9 Streptococcus dysgalactiae] SEQ ID NO 101 WP_015017095.1 type II CRISPR RNA- ^■guided endonuclease Cas9 Streptococcus dysgalactiae] SEQ ID NO 102 WP_015057649.1 type II CRISPR RNA- ^■guided endonuclease Cas9 Streptococcus dysgalactiae] SEQ ID NO 103 WP_048327215.1 type II CRISPR RNA- ^■guided endonuclease Cas9 Streptococcus dysgalactiae] SEQ ID NO 104 WP_049519324.1 CRISPR-associated protein Csnl [Streptococcus dysgalactiae] SEQ ID NO: 105

WP_012515931.1 type II CRISPR RNA-guided endonuclease Cas9 Streptococcus equi] SEQ ID NO 106

WP_021320964.1 type II CRISPR RNA-guided endonuclease Cas9 Streptococcus equi] SEQ ID NO 107

WP_037581760.1 type II CRISPR RNA-guided endonuclease Cas9 Streptococcus equi] SEQ ID NO 108

WP_004232481.1 type II CRISPR RNA-guided endonuclease Cas9 Streptococcus equinus] SEQ ID NO: 109 WP_009854540.1 type II CRISPR RNA-guided endonuclease Cas9 Streptococcus gallolyticus ] SEQ ID NO 110 WP_012962174.1 type II CRISPR RNA-guided endonuclease Cas9 Streptococcus gallolyticus ] SEQ ID NO 111 WP_039695303.1 type II CRISPR RNA-guided endonuclease Cas9 Streptococcus gallolyticus ] SEQ ID NO 112 WP_014334983.1 type II CRISPR RNA-guided endonuclease Cas9 Streptococcus infantarius ] SEQ ID NO: 113 WP_003099269.1 type II CRISPR RNA-guided endonuclease Cas9 Streptococcus iniae] SEQ ID NO: 114

AHY15608.1 CRISPR- -associated protein Csnl [Streptococcus iniae] SEQ ID NO: 115

AHY17476.1 CRISPR- -associated protein Csnl [Streptococcus iniae] SEQ ID NO: 116

ESR09100.1 hypothetical protein IUSA1_08595 [Streptococcus iniae IUSA1] SEQ ID NO: 117

AGM98575.1 CRISPR-associated protein Cas9/Csnl, subtype II/NMEMI [Streptococcus iniae SF1] SEQ ID NO: 118 ALF27331.1 CRISPR-associated protein Csnl [Streptococcus intermedius] SEQ ID NO: 119

WP_018372492.1 type II CRISPR RNA-guided endonuclease Cas9 [ Streptococcus massiliensis ] SEQ ID NO: 120 WP_045618028.1 type II CRISPR RNA-guided endonuclease Cas9 [ Streptococcus mitis ] SEQ ID NO: 121

WP_045635197.1 type II CRISPR RNA-guided endonuclease Cas9 [ Streptococcus mitis ] SEQ ID NO: 122

WP_002263549.1 type II CRISPR RNA-guided endonuclease Cas9 [ Streptococcus mutans ] SEQ ID NO 123 WP_002263887.1 type II CRISPR RNA-guided endonuclease Cas9 [ Streptococcus mutans ] SEQ ID NO 124 WP_002264920.1 type II CRISPR RNA-guided endonuclease Cas9 [ Streptococcus mutans ] SEQ ID NO 125 WP 002269043.1 type II CRISPR RNA-guided endonuclease Cas9 [ Streptococcus mutans ] SEQ ID NO 126

WP 002269448.1 type II CRISPR RNA-guided endonuclease Cas9 [ Streptococcus mutans ] SEQ ID NO: 127

WP ^"002271977. 1 type II CRISPR RNA- ^■guided endonuclease Cas9 [Streptococcus mutans ] SEQ ID NO: 128

WP ^"002272766. 1 type II CRISPR RNA- ^■guided endonuclease Cas9 [Streptococcus mutans ] SEQ ID NO: 129

WP ^"002273241. 1 type II CRISPR RNA- ^■guided endonuclease Cas9 [Streptococcus mutans ] SEQ ID NO: 130

WP ^"002275430. 1 type II CRISPR RNA- ^■guided endonuclease Cas9 [ Streptococcus mutans ] SEQ ID NO: 131

WP ^"002276448. 1 type II CRISPR RNA- ^■guided endonuclease Cas9 [ Streptococcus mutans ] SEQ ID NO: 132

WP ^"002277050. 1 type II CRISPR RNA- ^■guided endonuclease Cas9 [ Streptococcus mutans ] SEQ ID NO: 133

WP ^"002277364. 1 type II CRISPR RNA- ^■guided endonuclease Cas9 [ Streptococcus mutans ] SEQ ID NO: 134

WP ^"002279025. 1 type II CRISPR RNA- ^■guided endonuclease Cas9 [ Streptococcus mutans ] SEQ ID NO: 135

WP ^"002279859. 1 type II CRISPR RNA- ^■guided endonuclease Cas9 [ Streptococcus mutans ] SEQ ID NO: 136

WP ^"002280230. 1 type II CRISPR RNA- ^■guided endonuclease Cas9 [ Streptococcus mutans ] SEQ ID NO: 137

WP ^"002281696. 1 type II CRISPR RNA- ^■guided endonuclease Cas9 [ Streptococcus mutans ] SEQ ID NO: 138

WP ^"002282247. 1 type II CRISPR RNA- ^■guided endonuclease Cas9 [ Streptococcus mutans ] SEQ ID NO: 139

WP 002282906. , 1 type II CRISPR RNA- ^■guided endonuclease Cas9 [ Streptococcus mutans ] SEQ ID NO: 140

WP ^"002283846. , 1 type II CRISPR RNA- ^■guided endonuclease Cas9 [Streptococcus mutans ] SEQ ID NO: 141

WP ^"002287255. , 1 type II CRISPR RNA- ^■guided endonuclease Cas9 [Streptococcus mutans ] SEQ ID NO: 142

WP ^"002288990. , 1 type II CRISPR RNA- ^■guided endonuclease Cas9 [ Streptococcus mutans ] SEQ ID NO: 143

WP ^"002289641. , 1 type II CRISPR RNA- ^■guided endonuclease Cas9 [ Streptococcus mutans ] SEQ ID NO: 144

WP ^"002290427. , 1 type II CRISPR RNA- ^■guided endonuclease Cas9 [ Streptococcus mutans ] SEQ ID NO: 145

WP ^"002295753. , 1 type II CRISPR RNA- ^■guided endonuclease Cas9 [ Streptococcus mutans ] SEQ ID NO: 146

WP ^"002296423. , 1 type II CRISPR RNA- ^■guided endonuclease Cas9 [ Streptococcus mutans ] SEQ ID NO: 147

WP ^"002304487. , 1 type II CRISPR RNA- ^■guided endonuclease Cas9 [ Streptococcus mutans ] SEQ ID NO: 148

WP ^"002305844. , 1 type II CRISPR RNA- ^■guided endonuclease Cas9 [ Streptococcus mutans ] SEQ ID NO: 149

WP ^"002307203. , 1 type II CRISPR RNA- ^■guided endonuclease Cas9 [ Streptococcus mutans ] SEQ ID NO: 150

WP ^"002310390. , 1 type II CRISPR RNA- ^■guided endonuclease Cas9 [ Streptococcus mutans ] SEQ ID NO: 151

WP ^"002352408. , 1 type II CRISPR RNA- ^■guided endonuclease Cas9 [ Streptococcus mutans ] SEQ ID NO: 152

WP ^"012997688. .1 type II CRISPR RNA- ^■guided endonuclease Cas9 [Streptococcus mutans ] SEQ ID NO: 153

WP ^"014677909. .1 type II CRISPR RNA- -guided endonuclease Cas9 [Streptococcus mutans ] SEQ ID NO: 154

WP ^"019312892. .1 type II CRISPR RNA- -guided endonuclease Cas9 [Streptococcus mutans ] SEQ ID NO: 155

WP ^"019313659. .1 type II CRISPR RNA- -guided endonuclease Cas9 [ Streptococcus mutans ] SEQ ID NO: 156

WP ^"019314093. .1 type II CRISPR RNA- -guided endonuclease Cas9 [ Streptococcus mutans ] SEQ ID NO: 157

WP ^"019315370. .1 type II CRISPR RNA- -guided endonuclease Cas9 [ Streptococcus mutans ] SEQ ID NO: 158

WP ^"019803776. .1 type II CRISPR RNA- -guided endonuclease Cas9 [ Streptococcus mutans ] SEQ ID NO: 159

WP ^"019805234. .1 type II CRISPR RNA- -guided endonuclease Cas9 [ Streptococcus mutans ] SEQ ID NO: 160

WP ^"024783594. .1 type II CRISPR RNA- -guided endonuclease Cas9 [ Streptococcus mutans ] SEQ ID NO: 161

WP ^"024784288. .1 type II CRISPR RNA- -guided endonuclease Cas9 [ Streptococcus mutans ] SEQ ID NO: 162

WP ^"024784666. .1 type II CRISPR RNA- -guided endonuclease Cas9 [ Streptococcus mutans ] SEQ ID NO: 163

WP ^"024784894. .1 type II CRISPR RNA- -guided endonuclease Cas9 [ Streptococcus mutans ] SEQ ID NO: 164

WP ^"024786433. .1 type II CRISPR RNA- -guided endonuclease Cas9 [ Streptococcus mutans ] SEQ ID NO: 165

WP_049473442 1 CRISPR-associated protein Csnl [Streptococcus mutans] SEQ ID NO: 166

WP_049474547 1 CRISPR-associated protein Csnl [Streptococcus mutans] SEQ ID NO: 167

EMC03581.1 hypothetical protein SMU69_09359 [Streptococcus mutans NLML4] SEQ ID NO: 168

WP 000428612 1 type II CRISPR RNA-guided endonuclease Cas9 [Streptococcus oralis] SEQ ID NO: 169

WP ^"000428613 1 type II CRISPR RNA-guided endonuclease Cas9 [Streptococcus oralis] SEQ ID NO: 170

WP ^"049523028 1 CRISPR-associated protein Csnl [Streptococcus parasanguinis ] SEQ ID NO: 171

WP ^"003107102 1 type II CRISPR RNA-guided endonuclease Cas9 [Streptococcus parauberis] SEQ ID NO: 172

WP ^"054279288 1 type II CRISPR RNA-guided endonuclease Cas9 [Streptococcus phocae] SEQ ID NO 173

WP ^"049531101 1 CRISPR-associated protein Csnl [Streptococcus pseudopneumoniae] SEQ ID NO 174

WP ^"049538452 1 CRISPR-associated protein Csnl [Streptococcus pseudopneumoniae] SEQ ID NO 175

WP ^"049549711 1 CRISPR-associated protein Csnl [Streptococcus pseudopneumoniae] SEQ ID NO 176

WP ^"007896501 1 type II CRISPR RNA-guided endonuclease Cas9 [Streptococcus pseudoporcinus ] SEQ ID NO: 177

EFR44625.1 CRISPR-associated protein, Csnl family [Streptococcus pseudoporcinus SPIN 20026] SEQ ID NO: 178 WP_002897477 type II CRISPR RNA-guided endonuclease Cas9 [Streptococcus sanguinis] SEQ ID NO 179 WP_002906454 type II CRISPR RNA-guided endonuclease Cas9 [Streptococcus sanguinis] SEQ ID NO 180 WP_009729476 type II CRISPR RNA-guided endonuclease Cas9 [Streptococcus sp. F0441] SEQ ID NO 181 CQR24647.1 CRISPR-associated protein [Streptococcus sp FF10] SEQ ID NO: 182

WP 000066813 type II CRISPR RNA-guided endonuclease Cas9 [Streptococcus sp. M334] SEQ ID NO: 183

WP ^"009754323 type II CRISPR RNA-guided endonuclease Cas9 [Streptococcus sp taxon 056] SEQ ID NO 184

WP ^"044674937 type II CRISPR RNA-guided endonuclease Cas9 [Streptococcus suis] SEQ ID NO

WP ^"044676715 type II CRISPR RNA-guided endonuclease Cas9 [Streptococcus suis] SEQ ID NO

WP ^"044680361 type II CRISPR RNA-guided endonuclease Cas9 [Streptococcus suis] SEQ ID NO

WP ^"044681799 type II CRISPR RNA-guided endonuclease Cas9 [Streptococcus suis] SEQ ID NO

WP ^"049533112 CRISPR-associated protein Csnl [Streptococcus suis] SEQ ID NO: HΪ9

WP ^"029090905 type II CRISPR RNA-guided endonuclease Cas9 [Brochothrix thermosphacta] SEQ ID NO: 190

WP ^"006506696 type II CRISPR RNA-guided endonuclease Cas9 [ Catenibacterium mitsuokai] SEQ ID NO: 191

AIT42264.1 Cas9hc:NLS:HA [Cloning vector pYB196] SEQ ID NO: 192

WP_034440723 type II CRISPR endonuclease Cas9 [ Clostridiales bacterium S5-A11] SEQ ID NO: 193

AKQ21048.1 Cas9 [CRISPR-mediated gene targeting vector p (bhsp68-Cas 9 ) ] SEQ ID NO: 194

WP_004636532 type II CRISPR RNA-guided endonuclease Cas9 [ Dolosigranulum pigrum] SEQ ID NO: 195

WP_002364836 MULTISPECIES : type II CRISPR RNA-guided endonuclease Cas9 [ Enterococcus ] SEQ ID NO: 196

WP_016631044 MULTISPECIES : type II CRISPR RNA-guided endonuclease Cas9 [Enterococcus] SEQ ID NO: 197

EMS75795.1 hypothetical protein H318 06676 [Enterococci s durans IPLA 655] SEQ ID NO: 198

WP_002373311 type II CRISPR RNA-guided endonuclease Cas9 [ Enterococcus faecalis ] SEQ ID NO 199

WP_002378009 type II CRISPR RNA-guided endonuclease Cas9 [ Enterococcus faecalis ] SEQ ID NO 200

WP_002407324 type II CRISPR RNA-guided endonuclease Cas9 [ Enterococcus faecalis ] SEQ ID NO 201

WP_002413717 type II CRISPR RNA-guided endonuclease Cas9 [ Enterococcus faecalis ] SEQ ID NO 202

WP_010775580 type II CRISPR RNA-guided endonuclease Cas9 [ Enterococcus faecalis ] SEQ ID NO 203

WP 010818269 type II CRISPR RNA-guided endonuclease Cas9 [ Enterococcus faecalis ] SEQ ID NO 204

WP_010824395 1 type II CRISPR RNA--guided endonuclease Cas9 Enterococcus faecalis ] SEQ ID NO 205

WP_016622645 1 type II CRISPR RNA- -guided endonuclease Cas9 Enterococcus faecalis ] SEQ ID NO 206

WP_033624816 1 type II CRISPR RNA- -guided endonuclease Cas9 Enterococcus faecalis ] SEQ ID NO 207

WP_033625576 1 type II CRISPR RNA- -guided endonuclease Cas9 Enterococcus faecalis ] SEQ ID NO 208

WP_033789179 1 type II CRISPR RNA- -guided endonuclease Cas9 Enterococcus faecalis ] SEQ ID NO 209

WP_002310644 1 type II CRISPR RNA- -guided endonuclease Cas9 Enterococcus faecium] SEQ ID NO 210

WP_002312694 1 type II CRISPR RNA- -guided endonuclease Cas9 Enterococcus faecium] SEQ ID NO 211

WP_002314015 1 type II CRISPR RNA- -guided endonuclease Cas9 Enterococcus faecium] SEQ ID NO 212

WP_002320716 1 type II CRISPR RNA- -guided endonuclease Cas9 Enterococcus faecium] SEQ ID NO 213

WP_002330729 1 type II CRISPR RNA- -guided endonuclease Cas9 Enterococcus faecium] SEQ ID NO 214

WP_002335161 1 type II CRISPR RNA- -guided endonuclease Cas9 Enterococcus faecium] SEQ ID NO 215

WP_002345439 1 type II CRISPR RNA- -guided endonuclease Cas9 Enterococcus faecium] SEQ ID NO 216

WP_034867970 1 type II CRISPR RNA- -guided endonuclease Cas9 Enterococcus faecium] SEQ ID NO 217

WP_047937432 1 type II CRISPR RNA- -guided endonuclease Cas9 Enterococcus faecium] SEQ ID NO 218

WP_010720994 1 type II CRISPR RNA- -guided endonuclease Cas9 Enterococcus hirae] SEQ ID NO 219

WP_010737004 1 type II CRISPR RNA- -guided endonuclease Cas9 Enterococcus hirae] SEQ ID NO 220

WP_034700478 1 type II CRISPR RNA- -guided endonuclease Cas9 Enterococcus hirae] SEQ ID NO 221

WP_007209003 1 type II CRISPR RNA- -guided endonuclease Cas9 Enterococcus italicus] SEQ ID NO: 222

WP_023519017 1 type II CRISPR RNA- -guided endonuucclleeaassee CCaass99 [Enterococcus mundtii] SEQ ID NO: 223

WP_010770040 1 type II CRISPR RNA- -guided endonuucclleeaassee CCaass99 [Enterococcus phoeniculicola] SEQ ID NO

WP_048604708 1 type II CRISPR RNA- -guided endonuucclleeaassee CCaass99 [Enterococcus sp. AMI] SEQ ID NO: 225

WP_010750235 1 type II CRISPR RNA- -guided endonuucclleeaassee CCaass99 [Enterococcus villorum] SEQ ID NO: 226

AII16583.1 Cas9 endonuclease [Expression veeccttoorr ppCCaass99]] SEQ ID NO: 227

WP_029073316 1 type II CRISPR RNA- -guided endonuucclleeaassee CCaass99 [Kandleria vitulina] SEQ ID NO: 228

WP_031589969 1 type II CRISPR RNA- -guided endonuucclleeaassee CCaass99 [Kandleria vitulina] SEQ ID NO: 229

KDA45870.1 CRISPR-associated protein Cas9/Csnl, subtype II/NMEMI [Lactobacillus animalis] SEQ ID NO:

WP_039099354 type II CRISPR RNA-guided endonuclease Cas9 [Lactobacillus curvatus] SEQ ID NO: 231

AKP02966.1 hypothetical protein ABB45 04605 [Lactobacillus farciminis] SEQ ID NO: 232

WP_010991369 type II CRISPR RNA-guided endonuclease Cas9 [Listeria innocua] SEQ ID NO: 233

WP_033838504 type II CRISPR RNA-guided endonuclease Cas9 [Listeria innocua] SEQ ID NO: 234

EHN60060.1 CRISPR-associated protein, Csnl family [Listeria innocua ATCC 33091] SEQ ID NO: 235

EFR89594.1 crispr-associated protein, Csnl family [Listeria innocua FSL S4-378] SEQ ID NO: 236

WP_038409211 type II CRISPR RNA-guided endonuclease Cas9 [Listeria ivanovii] SEQ ID NO: 237

EFR95520.1 crispr-associated protein Csnl [Listeria ivanovii FSL F6-596] SEQ ID NO: 238

WP_003723650 typ II CRISPR RNA-guided endonuclease Cas9 [Listeria monocytogenes] SEQ ID NO 239

WP_003727705 typ II CRISPR RNA-guided endonuclease Cas9 [Listeria monocytogenes] SEQ ID NO 240

WP_003730785 typ II CRISPR RNA-guided endonuclease Cas9 [Listeria monocytogenes] SEQ ID NO 241

WP_003733029 typ II CRISPR RNA-guided endonuclease Cas9 [Listeria monocytogenes] SEQ ID NO 242

WP 003739838 typ II CRISPR RNA-guided endonuclease Cas9 [Listeria monocytogenes] SEQ ID NO 243

WP_014601172 s] SEQ ID NO 244 WP_023548323 s] SEQ ID NO 245 WP_031665337 s] SEQ ID NO 246 WP_031669209 s] SEQ ID NO 247 WP_033920898 s] SEQ ID NO 248 AKI42028.1 CRISPR-associated protein [Listeria monocytogenes] SEQ ID NO: 249

AKI50529.1 CRISPR-associated protein [Listeria monocytogenes] SEQ ID NO: 250

EFR83390.1 crispr-associated protein Csnl [Listeria monocytogenes FSL F2-208] SEQ ID NO: 251 WP_046323366 1 type II CRISPR RNA-guided endonuclease Cas9 [Listeria seeligeri] SEQ ID NO: 252 AKE81 Oil.1 Cas9 [Plant multiplex genome editing vector pYLCRISPR/Cas9Pubi-H] SEQ ID NO: 253 CU082355.1 Uncharacterized protein conserved in bacteria [Roseburia hominis] SEQ ID NO: 254 WP_033162 7.1 type II CRISPR RNA-guided endonuclease Cas9 [Sharpea azabuensis] SEQ ID NO: 255 AGZ01981.1 Cas9 endonuclease [synthetic construct] SEQ ID NO: 256

AKA60242.1 nuclease deficient Cas9 [synthetic construct] SEQ ID NO: 257

AKS40380.1 Cas9 [Synthetic plasmid pFC330] SEQ ID NO: 258

4UN5 B Cas9 Chain B, Crystal Structure SEQ ID NO: 259

WP_0109222 51 MDKK-YSIGL^|lGTNSVG AVITDEYKVPSKKFKVLGNTDRHSIKKNLIGALLFDSGETA—EATRLKRTARRRYT 73

WP_039695303 MTKKnYSIGLDIGTNSVGWAVITDDYKVPAKKMKVLGNTDKKYIKKNLLGALLFDSGETA—EATRLKRTARRRYT 74

WP_045635197 K-KG-YSIGLDIGTNSVGFAVITDDYKVPSKKMKVLGNTDKRFIKKNLIGALLFDEGTTA—EARRLKRTARRRYT 73

5AXW_A MKRN-YILGLDIGITSVGYGII—DYET RDVIDA GVRLFKEANVEnnEGRRSKRGARRLKR 61

WP_0098806 83

WP_010922251 MDKK-YSIGLDIGTNSVGWAVITDEYKVPS KKFKVLGNTDRHSIKKNLIGALLFDSGETA- -EATRLKRTARRRYT 73

WP_011054416 MDKK-YSIGLDIGTNSVGWAVITDDYKVPSKKLKGLGNTDRHGIKKNLIGALLFDSGETA- -EATRLKRTARRRYT 73

WP_011284745 MDKK-YSIGLDIGTNSVGWAVITDDYKVPSKKFKVLGNTDRHSIKKNLIGALLFDSGETA- -EATRLKRTARRRYT 73

WP_011285506 MDKK-YSIGLDIGTNSVGWAVITDDYKVPSKKFKVLGNTDRHSIKKNLIGALLFDSGETA- -EATRLKRTARRRYT 73

WP_011527619 MDKK-YSIGLDIGTNSVGWAVITDDYKVPSKKFKVLGNTDRHSIKKNLIGALLFDSGEIA- -EATRLKRTARRRYT 73

WP_012560673 MDKK-YSIGLDIGTNSVGWAVITDDYKVPSKKFKVLGNTDRHSIKKNLIGALLFDSGETA- -EATRLKRTARRRYT 73

WP_014407541 MDKK-YSIGLDIGTNSVGWAVITDDYKVPSKKFKVLGNTDRHSIKKNLIGALLFGSGETA- -EATRLKRTARRRYT 73

WP_020905136 MDKK-YSIGLDIGTNSVGWAVITDDYKVPSKKFKVLGNTDRHSIKKNLIGALLFDSGETA- -EATRLKRTARRRYT 73

WP_023080005 MDKK-YSIGLDIGTNSVGWAVITDDYKVPSKKLKVLGNTDRHGIKKNLIGALLFDSGETA- -EATRLKRTARRRYT 73

WP_023610282 MDKK-YSIGLDIGTNSVGWAVITDDYKVPSKKLKVLGNTDRHGIKKNLIGALLFDSGETA- -EATRLKRTARRRYT 73

WP_030125963 MDKK-YSIGLDIGTNSVGWAVITDDYKVPSKKFKVLGNTDRHSIKKNLIGALLFDSGETA- -EATRLKRTARRRYT 73

WP_030126706 MDKK-YSIGLDIGTNSVGWAVITDDYKVPSKKFKVLGNTDRHGIKKNLIGALLFDSGETA- -EATRLKRTARRRYT 73

WP_031488318 MDKK-YSIGLDIGTNSVGWAVITDDYKVPSKKFKVLGNTDRHSIKKNLIGALLFDSGETA- -EATRLKRTARRRYT 73

WP_032460140 MDKK-YSIGLDIGTNSVGWAVITDDYKVPSKKFKVLGNTDRHSIKKNLIGALLFDSGETA- -EATRLKRTARRRYT 73

WP_032461047 MDKK-YSIGLDIGTNSVGWAVITDDYKVPSKKFKVLGNTDRHSIKKNLIGALLFDSGETA- -EATRLKRTARRRYT 73

WP_032462016 MDKK-YSIGLDIGTNSVGWAVITDDYKVPSKKFKVLGNTDRHSIKKNLIGALLFDSGETA- -EATRLKRTARRRYT 73

WP 032462936 MDKK-YSIGLDIGTNSVGWAVITDDYKVPSKKFKVLGNTDRHSIKKNLIGALLFDSGETA- -EATRLKRTARRRYT 73

WP_032464890 MDKK-YSIGLDIGTNSVGWAVITDDYKVPSKKFKVLGNTDRHSIKKNLIGALLFDSGEIA—EATRLKRTARRRYT 73 WP_03 3888930

WP_03 8431314 MDKK-YSIGLDIGTNSVGWAVITDDYKVPSKKFKVLGNTDRHSIKKNLIGALLFDSGETA—EATRLKRTARRRYT 73 WP_03 8432938 MDKK-YSIGLDIGTNSVGWAVITDDYKVPSKKFKVLGNTDRHSIKKNLIGALLFDSGETA—EATRLKRTARRRYT 73 WP_03 8434062 MDKK-YSIGLDIGTNSVGWAVITDDYKVPSKKFKVLGNTDRHSIKKNLIGALLFDSGETA—EATRLKRTARRRYT 73 BAQ51 233

KGE60 162

KGE60 856

WP_00 29899 55 MDKK-YSIGLDIGTNSVGWAVITDDYKVPSKKFKVLGNTDRHSI KKNLIGALLFDSGEIA- -EATRLKRTARRRYT 73 WP_00 3030002 MDQK-YSIGLDIGTNSVGWAWTDDYKVPAKKMKVLGNTDKQSI KKNLLGALLFDSGETA- -EATRLKRTARRRYT 73 WP_00 3065552 MTKKnYSIGLDIGTNSVGWAVITDDYKVPAKKMKVLGNTDKKYI KKNLLGALLFDSGETA- -EATRLKRTARRRYT 74 WP_00 1040076 MNKP-YSIGLDIGTNSVGWSIITDDYKVPAKKIRVLGNTDKEYI KKNLIGALLFDGGNTA- -ADRRLKRTARRRYT 73 WP_00 1040078 MNKP-YSIGLDIGTNSVGWSIITDDYKVPAKKMRVLGNTDKEYI KKNLIGALLFDGGNTA- -ADRRLKRTARRRYT 73 WP_00 1040080 MNKP-YSIGLDIGTNSVGWSIITDDYKVPAKKMRVLGNTDKEYI KKNLIGALLFDGGNTA- -ADRRLKRTARRRYT 73 WP_00 1040081 MNKP-YSIGLDIGTNSVGWSIITDDYKVPAKKMRVLGNTDKEYI KKNLIGALLFDGGNTA- -ADRRLKRTARRRYT 73 WP_00 1040083 MNKP-YSIGLDIGTNSVGWSIITDDYKVPAKKMRVLGNTDKEYI KKNLIGALLFDGGNTA- -ADRRLKRTARRRYT 73 WP_00 1040085 MNKP-YSIGLDIGTNSVGWSIITDDYKVPAKKMRVLGNTDKEYI KKNLIGALLFDGGNTA- -ADRRLKRTARRRYT 73 WP_00 1040087 MNKP-YSIGLDIGTNSVGWSIITDDYKVPAKKMRVLGNTDKEYI KKNLIGALLFDGGNTA- -ADRRLKRTARRRYT 73 WP_00 1040088 MNKP-YSIGLDIGTNSVGWSIITDDYKVPAKKMRVLGNTDKEYI KKNLIGALLFDGGNTA- -ADRRLKRTARRRYT 73 WP_00 1040089 MNKP-YSIGLDIGTNSVGWSIITDDYKVPAKKMRVLGNTDKEYI KKNLIGALLFDGGNTA- -ADRRLKRTARRRYT 73 WP_00 1040090 MNKP-YSIGLDIGTNSVGWSIITDDYKVPAKKMRVLGNTDKEYI KKNLIGALLFDGGNTA- -ADRRLKRTARRRYT 73 WP_00 1040091 MNKP-YSIGLDIGTNSVGWSIITDDYKVPAKKMRVLGNTDKEYI KKNLIGALLFDGGNTA- -ADRRLKRTARRRYT 73 WP_00 1040092 MNKP-YSIGLDIGTNSVGWSIITDDYKVPAKKMRVLGNTDKEYI KKNLIGALLFDGGNTA- -ADRRLKRTARRRYT 73 WP_00 1040094 MNKP-YSIGLDIGTNSVGWSIITDDYKVPAKKMRVLGNTDKEYI KKNLIGALLFDGGNTA- -ADRRLKRTARRRYT 73 WP_00 1040095 MNKP-YSIGLDIGTNSVGWSIITDDYKVPAKKMRVLGNTDKEYI KKNLIGALLFDGGNTA- -ADRRLKRTARRRYT 73 WP_00 1040096 MNKP-YSIGLDIGTNSVGWSIITDDYKVPAKKMRVLGNTDKEYI KKNLIGALLFDGGNTA- -ADRRLKRTARRRYT 73 WP_00 1040097 MNKP-YSIGLDIGTNSVGWSIITDDYKVPAKKMRVLGNTDKEYI KKNLIGALLFDGGNTA- -ADRRLKRTARRRYT 73 WP_00 1040098 MNKP-YSIGLDIGTNSVGWSIITDDYKVPAKKMRVLGNTDKEYI KKNLIGALLFDGGNTA- -ADRRLKRTARRRYT 73 WP_00 1040099 MNKP-YSIGLDIGTNSVGWSIITDDYKVPAKKMRVLGNTDKEYI KKNLIGALLFDGGNTA- -ADRRLKRTARRRYT 73 WP_00 1040100 MNKP-YSIGLDIGTNSVGWSIITDDYKVPAKKMRVLGNTDKEYI KKNLIGALLFDGGNTA- -ADRRLKRTARRRYT 73 WP_00 1040104 MNKP-YSIGLDIGTNSVGWSIITDDYKVPAKKMRVLGNTDKEYI KKNLIGALLFDGGNTA- -ADRRLKRTARRRYT 73 WP_00 1040105 MNKP-YSIGLDIGTNSVGWSIITDDYKVPAKKMRVLGNTDKEYI KKNLIGALLFDGGNTA- -ADRRLKRTSRRRYT 73 WP_00 1040106 MNKP-YSIGLDIGTNSVGYSWTDDYKVPAKKMRVLGNTDKEYI KKNLIGALLFDGGNTA- -SDRRLKRTARRRYT 73 WP_00 1040107 MNKP-YSIGLDIGTNSVGYSWTDDYKVPAKKMRVLGNTDKEYI KKNLIGALLFDGGNTA- -SDRRLKRTARRRYT 73 WP_00 1040108 MNKP-YSIGLDIGTNSVGYSWTDDYKVPAKKMRVLGNTDKEYI KKNLIGALLFDGGNTA- -SDRRLKRTARRRYT 73 WP_00 1040109 MNKP-YSIGLDIGTNSVGYSWTDDYKVPAKKMRVLGNTDKEYI KKNLIGALLFDGGNTA- -SDRRLKRTARRRYT 73 WP_00 1040110 MNKP-YSIGLDIGTNSVGYSWTDDYKVPAKKMRVLGNTDKEYI KKNLIGALLFDGGNTA- -SDRRLKRTARRRYT 73 WP_01 5058523 MNKP-YSIGLDIGTNSVGWSIITDDYKVPAKKMRVLGNTDKEYI KKNLIGALLFDGGNTA- -ADRRLKRTARRRYT 73 WP 01 7643650 MNKP-YSIGLDIGTNSVGWSIITDDYKVPAKKMRVLGNTDKEYI KKNLIGALLFDGGNTA- -ADRRLKRTARRRYT 73

WP 017647151 1 MNKP-^■YSIGLDIGTNSVGWSIITDDYKVPAKKMRVLGNTDKEYIKKNLIGALLFDGGNTA--SDRRLKRTARRRYT 73

WP 017648376 1 MNKP- ^■YSIGLDIGTNSVGWSIITDDYKVPAKKMRVLGNTDKEYIKKNLIGALLFDGGNTA- -SDRRLKRTARRRYT 73

WP 017649527 1 MNKP- ^■YSIGLDIGTNSVGWSIITDDYKVPAKKMRVLGNTDKEYIKKNLIGALLFDGGNTA- -ADRRLKRTARRRYT 73

WP 017771611 1 MNKP- ^■YSIGLDIGTNSVGYSWTDDYKVPAKKMRVLGNTDKEYIKKNLIGALLFDGGNTA- -SDRRLKRTARRRYT 73

WP 017771984 1 MNKP- ^■YSIGLDIGTNSVGWSIITDDYKVPAKKMRVLGNTDKEYIKKNLIGALLFDGGNTA- -ADRRLKRTARRRYT 73

CFQ25032 1 MNKP- ^■YSIGLDIGTNSVGWSIITDDYKVPAKKMRVLGNTDKEYIKKNLIGALLFDGGNTA- -ADRRLKRTARRRYT 73

CFV16040 1 MNKP- ^■YSIGLDIGTNSVGWSIITDDYKVPAKKMRVLGNTDKEYIKKNLIGALLFDGGNTA- -ADRRLKRTARRRYT 73

KLJ37842 1 MNKP- ^■YSIGLDIGTNSVGWSIITDDYKVPAKKMRVLGNTDKEYIKKNLIGALLFDGGNTA- -ADRRLKRTARRRYT 73

KLJ72361 1 MNKP- ^■YSIGLDIGTNSVGWSIITDDYKVPAKKMRVLGNTDKEYIKKNLIGALLFDGGNTA- -ADRRLKRTARRRYT 73

KLL20707 1 MNKP- ^■YSIGLDIGTNSVGWSIITDDYKVPAKKMRVLGNTDKEYIKKNLIGALLFDGGNTA- -ADRRLKRTARRRYT 73

KLL42645 1 MNKP- ^■YSIGLDIGTNSVGYSWTDDYKVPAKKMRVLGNTDKEYIKKNLIGALLFDGGNTA- -SDRRLKRTARRRYT 73

WP 047207273 1 MNKP- ^■YSIGLDIGTNSVGWSIITDDYKVPAKKMRVLGNTDKEYIKKNLIGALLFDGRNTA- -ADRRLKRTARRRYT 73

WP 047209694 1 MNKP- ^■YSIGLDIGTNSVGWSIITDDYKVPAKKMRVLGNTDKEYIKKNLIGALLFDGGNTA- -ADRRLKRTARRRYT 73

WP 050198062 1 MNKP- ^■YSIGLDIGTNSVGWSIITDDYKVPAKKMRVLGNTDKEYIKKNLIGALLFDGGNTA- -ADRRLKRTARRRYT 73

WP 050201642 1 MNKP- ^■YSIGLDIGTNSVGWSIITDDYKVPAKKMRVLGNTDKEYIKKNLIGALLFDGGNTA- -ADRRLKRTARRRYT 73

WP 050204027 1 MNKP- ^■YSIGLDIGTNSVGYSWTDDYKVPAKKMRVLGNTDKEYIKKNLIGALLFDGGNTA- -SDRRLKRTARRRYT 73

WP 050881965 1 MNKP- ^■YSIGLDIGTNSVGWSIITDDYKVPAKKMRVLGNTDKEYIKKNLIGALLFDGGNTA- -ADRRLKRTARRRYT 73

WP 050886065 1 MNKP- ^■YSIGLDIGTNSVGWSIITDDYKVPAKKMRVLGNTDKEYIKKNLIGALLFDGGNTA- -ADRRLKRTARRRYT 73

AHN30376 1 MNKP- ^■YSIGLDIGTNSVGWSIITDDYKVPAKKMRVLGNTDKEYIKKNLIGALLFDGGNTA- -ADRRLKRTARRRYT 73

EA078426 1 MNKP- ^■YSIGXDIGTNSVGWSIITDDYKVPAKKMRVLGNTDKEYIKKNLIGALLFDGGNTA- -ADRRLKRTARRRYT 73

CCW42055 1 MNKP- ^■YSIGLDIGTNSVGWSIITDDYKVPAKKMRVLGNTDKEYIKKNLIGALLFDGGNTA- -ADRRLKRIARRRYT 73

WP 003041502 1 MNQK- ^■YSIGLDIGTNSVGWAVITDDYKVPAKKMKVLGNTDKQSIKKNLLGALLFDSGETA- -EATRLKRTARRRYT 73

WP 037593752 1 MKKE- ^■YSIGLDIGTNSVGWAVITDDYKVPAKKMKVLGNTDKQSIKKNLLGALLFDSGETA- -EATRLKRTARRRYT 74

WP 049516684 1 MKKE- ^■YSIGLDIGTNSVGWAVITDDYKVPAKKMKVLGNTDKQSIKKNLLGALLFDSGETA- -EATRLKRTARRRYT 74

GAD46167 1 MKKE- ^■YSIGLDIGTNSVGWAVITDDYKVPAKKMKVLGNTDKQSIKKNLLGALLFDSGETA- -EATRLKRTARRRYT 73

WP 018363470 1 MTKKnYSIGLDIGTNSVGWAVITDDYKVPAKKMKVLGNTDKKYIKKNLLGALLFDSGETA- -EATRLKRTARRRYT 74

WP 003043819 1 MEKK- ^■YSIGLDIGTNSVGWAVITDDYKVPSKKFKVLGNTNRKSIKKNLMGALLFDSGETA- -EATRLKRTARRRYT 73

WP 006269658 1 MGKP- ^■YSIGLDIGTNSVGWAWTDDYKVPAKKMKVLGNTDKQSIKKNLLGALLFDSGETA- -EATRLKRTARRRYT 73

WP 048800889 1 MTQK- ^■YSIGLDIGTNSVGWAIVTDDYKVPAKKMKILGNTNKQYIKKNLLGALLFDSGETA- -KATRLKRTARRRYT 73

WP 012767106 1 MDKK- ^■YSIGLDIGTNSVGWAVITDDYKVPSKKFKVLGNTDRHSIKKNLIGALLFDSGETA- -EATRLKRTARRRYT 73

WP 014612333 1 MDKK- ^■YSIGLDIGTNSVGWAVITDDYKVPSKKFKVLGNTDRHSIKKNLIGALLFDSGETA- -EATRLKRTARRRYT 73

WP 015017095 1 MDKK- ^■YSIGLDIGTNSVGWAVITDDYKVPSKKFKVLGNTDRHSIKKNLIGALLFDSGETA- -EATRLKRTARRRYT 73

WP 015057649 1 MDKK- ^■YSIGLDIGTNSVGWAVITDDYKVPSKKFKVLGNTDRHSIKKNLIGALLFDSGETA- -EATRLKRTARRRYT 73

WP 048327215 1 MDKK- ^■YSIGLDIGTNSVGWAVITDDYKVPSKKFKVLGNTDRHSIKKNLIGALLFDSGETA- -EATRLKRTARRRYT 73

WP 049519324 1 MDKK- ^■YSIGLDIGTNSVGWAVITDDYKVPSKKFKVLGNTDRHSIKKNLIGALLFDSGETA- -EATRLKRTARRRYT 73

WP 012515931 1 MKKP- ^■YTIALDIGTNSVGWVWTDDYRVPTKKMKVLGNTERKTIKKNLIGALLFDSGDTA- -EGTRLKRTARRRYT 73

WP 021320964 1 MKKP- ^■YTIALDIGTNSVGWVWTDDYRVPTKKMKVLGNTERKTIKKNLIGALLFDSGDTA- -EGTRLKRTARRRYT 73

WP 037581760 1 MKKP- ^■YTIALDIGTNSVGWVWTDDYRVPTKKMKVLGNTERKTIKKNLIGALLFDSGDTA- -EGTRLKRTARPRYT 73

WP 004232481 1 M-EKtYSIGLDIGTNSVGWAVITDDYKVPAKKMKVLGNTDKKYIKKNLLGALLFDSGETA- -EATRLKRAARRRYT 73

WP_009854540 MTKKnYSIGLDIGTNSVGWAVITDDYKVPAKKMKVLGNTDKKYIKKNLLGALLFDSGETA- -EATRLKRTARRRYT 74 WP_01 2962174 MTEKnYSIGLDIGTNSVGWAVITDDYKVPAKKMKVLGNTDKKYIKKNLLGALLFDNGETA- -EATRLKRTARRRYT 74 WP_03 9695303 MTKKnYSIGLDIGTNSVGWAVITDDYKVPAKKMKVLGNTDKKYIKKNLLGALLFDSGETA- -EATRLKRTARRRYT 74 WP_01 4334983 M-EKsYSIGLDIGTNSVGWAVITDDYKVPAKKMKVLGNTDKKYIKKNLLGALLFDSGETA- -EVTRLKRTARRRYT 73 WP_00 3099269 MRKP-YSIGLDIGTNSVGWAVITDDYKVPSKKMRIQGTTDRTSIKKNLIGALLFDNGETA- -EATRLKRTTRRRYT 73 AHY15 608 MRKP-YSIGLDIGTNSVGWAVITDDYKVPSKKMRIQGTTDRTSIKKNLIGALLFDNGETA- -EATRLKRTTRRRYT 73 AHY17 476 MRKP-YSIGLDIGTNSVGWAVITDDYKVPSKKMRIQGTTDRTSIKKNLIGALLFDNGETA- -EATRLKRTTRRRYT 73 ESR09 100

AGM98 575 MRKP-YSIGLDIGTNSVGWAVITDDYKVPSKKMRIQGTTDRTSI KKNLIGALLFDNGETA-- EATRLKRTTRRRYT 73 ALF27 331 MKKP-YSIGLDIGTNSVGWAWTDDYKVPAKKMKVLGNTDKSHIKKNLLGALLFDSGNTA-- EDRRLKRTARRRYT 73 WP_01 83724 92 MKKP-YSIGLDIGTNSVGWAWMEDYKVPSKKMKVLGNTDKQSIKKNLIGALLFDSGETAv- -ERRLNRTTSRRYD 73 WP_04 5618028 NNKP-YSIGLDIGTNSVGWAVITDDYKVPSKKMKVLGNTDKHFIKKNLLGALLFDEGTTA-- EDRRLKRTARRRYT 74 WP_04 5635197 K-KG-YSIGLDIGTNSVGFAVITDDYKVPSKKMKVLGNTDKRFIKKNLIGALLFDEGTTA-- EARRLKRTARRRYT 73 WP_00 2263549 MKKP-YSIGLDIGTNSVGWAWTDDYKVPAKKMKVLGNTDKSHIEKNLLGALLFDSGNTA-- EDRRLKRTARRRYT 73 WP_00 2263887 MKKP-YSIGLDIGTNSVGWAWTDDYKVPAKKMKVLGNTDKSHIEKNLLGALLFDSGNTA-- EDRRLKRTARRRYT 73 WP_00 2264920 MKKP-YSIGLDIGTNSVGWAWTDDYKVPAKKMKVLGNTDKSHIKKNLLGALLFDSGNTA-- EDRRLKRTARRRYT 73 WP_00 2269043 MKKP-YSIGLDIGTNSVGWAWTDDYKVPAKKMKVLGNTDKSHIKKNLLGALLFDSGNTA-- EDRRLKRTARRRYT 73 WP_00 2269448 MKKP-YSIGLDIGTNSVGWAWTDDYKVPAKKMKVLGNTDKSHIKKNLLGALLFDSGNTA-- EDRRLKRTARRRYT 73 WP_00 2271977 MKKP-YSIGLDIGTNSVGWAWTDDYKVPAKKMKVLGNTDKSHIKKNLLGALLFDSGNTA-- EDRRLKRTARRRYT 73 WP_00 2272766 MKKP-YSIGLDIGTNSVGWAWTDDYKVPAKKMKVLGNTDKSHIKKNLLGALLFDSGNTA-- EDRRLKRTARRRYT 73 WP_00 2273241 MKKP-YSIGLDIGTNSVGWAWTDDYKVPAKKMKVLGNTDKSHIKKNLLGALLFDSGNTA-- EDRRLKRTARRRYT 73 WP_00 2275430 MKKP-YSIGLDIGTNSVGWAWTDDYKVPAKKMKVLGNTDKSHIKKNLLGALLFDSGNTA-- ADRRLKRTARRRYT 73 WP_00 2276448 MKKP-YSIGLDIGTNSVGWAWTDDYKVPAKKMKVLGNTDKSHIKKNLLGALLFDSGNTA-- EDRRLKRTARRRYT 73 WP_00 2277050 MKKS-YSIGLDIGTNSVGWAWTDDYKVPAKKMKVLGNTDKSHIKKNLLGALLFDSGNTA-- EDRRLKRTARRRYT 73 WP_00 2277364 MKKP-YSIGLDIGTNSVGWAWTDDYKVPAKKMKVLGNTDKSHIKKNLLGALLFDSGNTA-- ADRRLKRTARRRYT 73 WP_00 2279025 MKKP-YSIGLDIGTNSVGWAWTDDYKVPAKKMKVLGNTDKSHIEKNLLGALLFDSGNTA-- EDRRLKRTARRRYT 73 WP_00 2279859 MKKP-YSIGLDIGTNSVGWAWTDDYKVPAKKMKVLGNTDKSHIKKNLLGALLFDSGNTA-- EDRRLKRTARRRYT 73 WP_00 2280230 MKKP-YSIGLDIGTNSVGWAWTDDYKVPAKKMKVLGNTDKSHIKKNLLGALLFDSGNTA-- ADRRLKRTARRRYT 73 WP_00 2281696 MKKP-YSIGLDIGTNSVGWAWTDDYKVPAKKMKVLGNTDKSHIKKNLLGALLFDSGNTA-- ADRRLKRTARRRYT 73 WP_00 2282247 MKKP-YSIGLDIGTNSVGWAWTDDYKVPAKKMKVLGNTDKSHIKKNLLGALLFDSGNTA-- EDRRLKRTARRRYT 73 WP_00 2282906 MKKP-YSIGLDIGTNSVGWSWTDDYKVPAKKMKVLGNTDKSHIEKNLLGALLFDSGNTA-- EDRRLKRTARRRYT 73 WP_00 2283846 MKKP-YSIGLDIGTNSVGWAWTDDYKVPAKKMKVLGNTDKSHIKKNLLGALLFDSGNTA-- EDRRLKRTARRRYT 73 WP_00 2287255 MKKP-YSIGLDIGTNSVGWAWTDDYKVSAKKMKVLGNTDKSHIKKNLLGALLFDSGNTA-- EDRRLKRTARRRYT 73 WP_00 2288990 MKKP-YSIGLDIGTNSVGWAWTDDYKVPAKKMKVLGNTDKSHIKKNLLGALLFDSGNTA-- EDRRLKRTARRRYT 73 WP_00 2289641 MKKP-YSIGLDIGTNSVGWAWTDDYKVPAKKMKVLGNTDKSHIKKNLLGALLFDSGNTA-- EDRRLKRTTRRRYT 73 WP_00 2290427 MKKP-YSIGLDIGTNSVGWAWTDDYKVPAKKMKVLGNTDKSHIKKNLLGALLFDSGNTA-- EDRRLKRTARRRYT 73 WP_00 2295753 MKKP-YSIGLDIGTNSVGWAWTDDYKVPAKKMKVLGNTDKSHIKKNLLGALLFDSGNTA-- EDRRLKRTARRRYT 73 WP_00 2296423 MKKP-YSIGLDIGTNSVGWAWTDDYKVPAKKMKVLGNTDKSHIKKNLLGALLFDSGNTA-- EDRRLKRTARRRYT 73 WP 00 2304487 MKKP-YSIGLDIGTNSVGWAWTDDYKVPAKKMKVLGNTDKSHIKKNLLGALLFDSGNTA-- EDRRLKRTARRRYT 73

WP_002305844 MKKP-YSIGLDIGTNSVGWAWTDDYKVPAKKMKVLGNTDKSHIKKNLLGALLFDSGNTA EDRRLKRTARRRYT 73 WP_00 2307203 MKKP-YSIGLDIGTNSVGWAWTDDYKVPAKKMKVLGNTDKSHIKKNLLGALLFDSGNTA EDRRLKRTARRRYT 73 WP_00 2310390 MKKP-YSIGLDIGTNSVGWAWTDDYKVPAKKMKVLGNTDKSHIKKNLLGALLFDSGNTA EDRRLKRTARRRYT 73 WP_00 2352408 MKKP-YSIGLDIGTNSVGWAWTDDYKVPAKKMKVLGNTDKSHIKKNLLGALLFDSGNTA EDRRLKRTARRRYT 73 WP_01 2997688 MKKP-YSIGLDIGTNSVGWAWTDDYKVPAKKMKVLGNTDKSHIKKNLLGALLFDSGNTA ADRRLKRTARRRYT 73 WP_01 4677909 MKKP-YSIGLDIGTNSVGWAWTDDYKVPDKKMKVLGNTDKSHIKKNLLGALLFDSGNTA EDRRLKRTARRRYT 73 WP_01 9312892 MKKP-YSIGLDIGTNSVGWAWTDDYKVPAKKMKVLGNTDKSHIKKNLLGALLFDSGNTA ADRRLKRTARRRYT 73 WP_01 9313659 MKKP-YSIGLDIGTNSVGWAWTDDYKVPAKKMKVLGNTDKSHIEKNLLGALLFDSGNTA EDRRLKRTARRRYT 73 WP_01 9314093 MKKP-YSIGLDIGTNSVGWAWTDDYKVPAKKMKVLGNTDKSHIKKNLLGALLFDSGNTA EDRRLKRTARRRYT 73 WP_01 9315370 MKKP-YSIGLDIGTNSVGWAWTDDYKVPAKKMKVLGNTDKSHIKKNLLGALLFDSGNTA EDRRLKRTARRRYT 73 WP_01 9803776 MKKP-YSIGLDIGTNSVGWAWTDDYKVPAKKMKVLGNTDKSHIEKNLLGALLFDSGNTA EDRRLKRTARRRYT 73 WP_01 9805234 MKKP-YSIGLDIGTNSVGWAWTDDYKVPAKKMKVLGNTDKSHIKKNLLGALLFDSGNTA EDRRLKRTARRRYT 73 WP_02 4783594 MKKP-YSIGLDIGTNSVGWAWTDDYKVPAKKMKVLGNTDKSHIEKNLLGALLFDSGNTA EDRRLKRTARRRYT 73 WP_02 4784288 MKKP-YSIGLDIGTNSVGWAWTDDYKVPAKKMKVLGNTDKSHIKKNLLGALLFDSGNTA EDRRLKRTARRRYT 73 WP_02 4784666 MKKP-YSIGLDIGTNSVGWAWTDDYKVPAKKMKVLGNTDKSHIKKNLLGALLFDSGNTA ADRRLKRTARRRYT 73 WP_02 4784894 MKKP-YSIGLDIGTNSVGWAWTDDYKVPAKKMKVLGNTDKSHIKKNLLGALLFDSGNTA EDRRLKRTTRRRYT 73 WP_02 4786433 MKKP-YSIGLDIGTNSVGWAWTDDYKVPAKKMKVLGNTDKSHIKKNLLGALLFDSGNTA ADRRLKRTARRRYT 73 WP_04 9473442 MKKP-YSIGLDIGTNSVGWAWTDDYKVPAKKMKVLGNTDKSHIKKNLLGALLFDSGNTA ADRRLKRTARRRYT 73 WP_04 9474547 MKKP-YSIGLDIGTNSVGWAWTDDYKVPAKKMKVLGNTDKSHIKKNLLGALLFDSGNTA EDRRLKRTTRRRYT 73 EMC03 581 MDL IGTNSVGWAWTDDYKVPAKKMKVLGNTDKSHIKKNLLGALLFDSGNTA ADRRLKRTARRRYT 66 WP_00 04286 12 ENKN-YSIGLDIGTNSVGWAVITDDYKVPSKKMKVLGNTDKRFIKKNLIGALLFDEGTTA EARRLKRTARRRYT 74 WP_00 0428613 ENKN-YSIGLDIGTNSVGWSVITDDYKVPSKKMKVLGNTDKRFIKKNLIGALLFDEGTTA EARRLKRTARRRYT 74 WP_04 9523028 K-KP-YSIGLDIGTNSVGWAVITDDYKVPAKKMKVLGNTNKESIKKNLIGALLFDAGNTA ADRRLKRTARRRYT 73 WP_00 3107102 MKVLGNTDRQTVKKNMIGTLLFDSGETA EARRLKRTARRRYT 42 WP_05 4279288 -KKS-YSIGLDIGTNSVGWAVITDDYKVPAKKMKVLGNTSRQSIKKNMIGALLFDEGGPA ASTRVKRTTRRRYT 75 WP_04 9531101 SNKP-YSIGLDIGTNSVGWAVITDDYKVPSKKMKVLGNTDKHFIKKNLIGALLFDEGTTA EDRRLKRTARRRYT 74 WP_04 9538452 SNKP-YSIGLDIGTNSVGWVIITDDYKVPSKKMKVLGNTDKHFIKKNLIGALLFDEGTTA EDRRLKRTARRRYT 74 WP_04 9549711 SNKP-YSIGLDIGTNSVGWAVITDDYKVPSKKMTVLGNTDKHFIKKNLIGALLFDEGTTA EDRRLKRTARRRYT 74 WP_00 7896501 —YS-YSIGLDIGTNSVGWAVINEDYKVPAKKMTVFGNTDRKTIKKNLLGTVLFDSGETA QARRLKRTNRRRYT 75 EFR44 625 MLGTVLFDSGETA QARRLKRTNRRRYT 27 WP_00 28974 77 K-KP-YSIGLDIGTNSVGWAWTDDYKVPAKKMRVFGDTDRSHIKKNLLGTLLFDDGNTA ESRRLKRTARRRYT 73 WP_00 2906454 K-KP-YSIGLDIGTNSVGWAVITDDYKVPSKKMKVLGNTDKHFIKKNLIGALLFDEGTTA EDRRLKRTSRRRYT 73 WP_00 9729476 ENKN-YSIGLDIGTNSVGWSVITDDYKVPSKKMKVLGNTDKHFIKKNLIGALLFDEGTTA EARRLKRTARRRYT 74 CQR24 647 MKKP-YSIGLDIGTNSVGWSWTDDYKVPAKKMKVLGNTDKEYIKKNLIGALLFDSGETA EATRMKRTARRRYT 73 WP_00 00668 13 SNKS-YSIGLDIGTNSVGWAVITDDYKVPSKKMKVLGNTDKHFIKKNLIGALLFDEGTTA EDRRLKRTARRRYT 74 WP_00 9754323 NNNN-YSIGLDIGTNSVGWAVITDDYKVPSKKMRVLGNTDKRFIKKNLIGALLFDEGTTA EDRRLKRTARRRYT 74 WP_04 4674937 MKKK-YAIGIDIGTNSVGWSWTDDYKVPSKKMKVFGNTEKRYIKKNLLGTLLFDEGNTA ENRRLKRTARRRYT 73 WP_04 4676715 MKKK-YAIGIDIGTNSVGWSWTDDYKVPSKKMKVFGNTEKRYIKKNLLGTLLFDEGNTA ENRRLKRTARRRYT 73 WP 04 4680361 MKKK-YAIGIDIGTNSVGWSWTDDYKVPSKKMKVFGNTEKRYIKKNLLGTLLFDEGNTA ENRRLKRTARRRYT 73

WP_044681799 MKKK-YAIGIDIGTNSVGWSWTDDYKVPSKKMKVFGNTEKRYIKKNLLGTLLFDEGNTA- -ENRRLKRTARRRYT 73 WP_04 9533112 MDQK-YSIGLDIGTNSVGWAWTDDYKVPAKKMKVLGNTDKQSIKKNLLGALLFDSGETA- -EATRLKRTARRRYT 73 WP_02 9090905 MWGVSLFEAGKTA- -AERRGYRSTRRRLN 27 WP_00 6506696 I-VD-YCIGLDLGTGSVGWAWDMNHRLMKRN GKHLWGSRLFSNAETA- -ANRRASRSIRRRYN 60 AIT42 264 MDKK-YSIGLDIGTNSVGWAVITDEYKVPSKKFKVLGNTDRHSIKKNLIGALLFDSGETA- -EATRLKRTARRRYT 73 WP_03 44407 23 -MKN-YTIGLDIGTNSVGWAVIKDDLTLVRKKIKISGNTDKKEVKKNLWGSFLFEQGDTA- -QDTRVKRIARRRYE 72 AKQ21 048 MDKK-YSIGLDIGTNSVGWAVITDEYKVPSKKFKVLGNTDRHSIKKNLIGALLFDSGETA- -EATRLKRTARRRYT 73 WP_00 46365 32 MQKN-YTIGLDIGTNSVGWAVMKDDYTLIRKRMKVLGNTDIKKIKKNFWGVRLFDEGETA- -KETRLKRGTRRRYQ 73 WP_00 2364836 MKKD-YVIGLDIGTNSVGWAVMTEDYQLVKKKMPIYGNTEKKKIKKNFWGVRLFEEGHTA- -EDRRLKRTARRRIS 73 WP_01 6631044 MRLFEEGHTA- -EDRRLKRTARRRIS 24 EMS75 795

WP_00 23733 11 MKKD-YVIGLDIGTNSVGWAVMTEDYQLVKKKMPIYGNTEKKKIKKNFWGVRLFEEGHTA EDRRLKRTARRRIS 73 WP_00 2378009 MKKD-YVIGLDIGTNSVGWAVMTEDYQLVKKKMPIYGNTEKKKIKKNFWGVRLFEEGHTA EDRRLKRTARRRIS 73 WP_00 2407324 MKKD-YVIGLDIGTNSVGWAVMTEDYQLVKKKMPIYGNTEKKKIKKNFWGVRLFEEGHTA EDRRLKRTARRRIS 73 WP_00 2413717 MKKD-YVIGLDIGTNSVGWAVMTEDYQLVKKKMPIYGNTEKKKIKKNFWGVRLFEEGHTA EDRRLKRTARRRIS 73 WP_01 0775580 MKKD-YVIGLDIGTNSVGWAVMTEDYQLVKKKMPIYGNTEKKKIKKNFWGVRLFEEGHTA EDRRLKRTARRRIS 73 WP_01 0818269 MKKD-YVIGLDIGTNSVGWAVMTEDYQLVKKKMPIYGNTEKKKIKKNFWGVRLFEEGHTA EDRRLKRTARRRIS 73 WP_01 0824395 MKKD-YVIGLDIGSNSVGWAVMTEDYQLVKKKMPIYGNTEKKKIKKNFWGVRLFEEGHTA EDRRLKRTARRRIS 73 WP_01 6622645 MKKD-YVIGLDIGTNSVGWAVMTEDYQLVKKKMPIYGNTEKKKIKKNFWGVRLFEEGHTA EDRRLKRTARRRIS 73 WP_03 3624816 MKKD-YVIGLDIGTNSVGWAVMTEDYQLVKKKMPIYGNTEKKKIKKNFWGVRLFEEGHTA EDRRLKRTARRRIS 73 WP_03 3625576 MKKD-YVIGLDIGTNSVGWAVMTEDYQLVKKKMPIYGNTEKKKIKKNFWGVRLFEEGHTA EDRRLKRTARRRIS 73 WP_03 3789179 MKKD-YVIGLDIGTNSVGWAVMTEDYQLVKKKMPIYGNTEKKKIKKNFWGVRLFEEGHTA EDRRLKRTARRRIS 73 WP_00 2310644 MKKE-YTIGLDIGTNSVGWSVLTDDYRLVSKKMKVAGNTEKSSTKKNFWGVRLFDEGQTA EARRSKRTARRRLA 73 WP_00 2312694 MKKE-YTIGLDIGTNSVGWSVLTDDYRLVSKKMKVAGNTEKSSTKKNFWGVRLFDEGQTA EARRSKRTARRRLA 73 WP_00 2314015 MKKE-YTIGLDIGTNSVGWSVLTDDYRLVSKKMKVAGNTEKSSTKKNFWGVRLFDEGQTA EARRSKRTARRRLA 73 WP_00 2320716 MKKE-YTIGLDIGTNSVGWSVLTDDYRLVSKKMKVAGNTEKSSTKKNFWGVRLFDEGQTA EARRSKRTARRRLA 73 WP_00 2330729 MKKE-YTIGLDIGTNSVGWSVLTDDYRLVSKKMKVAGNTEKSSTKKNFWGVRLFDEGQTA EARRSKRTARRRLA 73 WP_00 2335161 MKKE-YTIGLDIGTNSVGWSVLTDDYRLVSKKMKVAGNTEKSSTKKNFWGVRLFDEGQTA EARRSKRTARRRLA 73 WP_00 2345439 MKKE-YTIGLDIGTNSVGWSVLTDDYRLVSKKMKVAGNTEKSSTKKNFWGVRLFDEGQTA EARRSKRTARRRLA 73 WP_03 4867970 MTKD-YTIGLDIGTNSVGWAVLTDDYQLMKRKMSVHGNTEKKKIKKNFWGARLFDEGQTA EFRRTKRTNRRRLA 73 WP_04 7937432 MKKE-YTIGLDIGTNSVGWSVLTDDYRLVSKKMKVAGNTEKSSTKKNFWGVRLFDEGQTA EARRSKRTARRRLA 73 WP_01 0720994 MTKD-YTIGLDIGTNSVGWAVLTDDYQLMKRKMSVHGNTEKKKIKKNFWGARLFDEGQTA EFRRTKRTNRRRLA 73 WP_01 0737004 MTKD-YTIGLDIGTNSVGWAVLTDDYQLMKRKMSVHGNTEKKKIKKNFWGARLFDEGQTA EFRRTKRTNRRRLA 73 WP_03 4700478 MTKD-YTIGLDIGTNSVGWAVLTDDYQLMKRKMSVHGNTEKKKIKKNFWGARLFDEGQTA EFRRTKRTNRRRLA 73 WP_00 7209003 MKND-YTIGLDIGTNSVGYSWTDDYKVISKKMNVFGNTEKKSIKKNFWGVRLFESGQTA QEARMKRTSRRRIA 73 WP_02 3519017 MEKE-YTIGLDIGTNSVGWAVLTDDYRLVARKMSIQGDSNRKKIKKNFWGARLFEEGKTA QFRRIKRTNRRRIA 73 WP_01 0770040 MKKE-YTIGLDIGTNSVGWAVLTENYDLVKKKMKVYGNTETKYLKKNLWGVRLFDEGETA ADRRLKRTTRRRYS 73 WP_04 8604708 MGKE-YTIGLDIGTNSVGWAVLQEDLDLVRRKMKVYGNTEKNYLKKNFWGVDLFDEGMTA KDTRLKRTTRRRYF 73 WP 01 0750235 MNKA-YTLGLDIGTNSVGWAWTDDYRLMAKKMPVHSKMEKKKIKKNFWGARLFDEGQTA EERRNKRATRRRLR 73

AII16583 ADKK-YSIGLDIGTNSVGWAVITDEYKVPSKKFKVLGNTDRHSIKKNLIGALLFDSGETA- ^■EATRLKRTARRRYT 112

WP_029073 316 NNKI-YNIGLDIGDASVGWAWDEHYNLLKRH GKHMWGSRLFTQANTA- ^■VERRSSRSTRRRYN 65

WP_031589969 NNKI-YNIGLDIGDASVGWAWDEHYNLLKRH GKHMWGSRLFTQANTA- ^■VERRSSRSTRRRYN 65

KDA45870 LKKD-YSIGLDIGTNSVGHAWTDDYKVPTKKMKVFGDTSKKTIKKNMLGVLLFNEGQTA- ^■ADTRLKRGARRRYT 74

WP_039099 354 MSRP-YNIGLDIGTSSIGWSWDDQSKLVSVR GKYGYGVRLYDEGQTA- ^■AERRSFRTTRRRLK 61

AKP02966 KEQP-YNIGLDIGTGSVGWAVTNDNYDLLNIK KKNLWGVRLFEGAQTA- ^■KETRLNRSTRRRYR 64

WP_010991 369 MKKP-YTIGLDIGTNSVGWAVLTDQYDLVKRKMKIAGDSEKKQIKKNFWGVRLFDEGQTA- ^■ADRRMARTARRRIE 73

WP_033838504 MKKP-YTIGLDIGTNSVGWAVLTDQYDLVKRKMKIAGDSEKKQIKKNFWGVRLFDEGQTA- ^■ADRRMARTARRRIE 73

EHN60060 MKKP-YTIGLDIGTNSVGWAVLTDQYDLVKRKMKIAGDSEKKQIKKNFWGVRLFDEGQTA- ^■ADRRMARTARRRIE 76

EFR89594

WP_038409 211 1 MRKP-YTIGLDIGTNSVGWAVLTDQYNLVKRKMKVAGSAEKKQIKKNFWGVRLFDEGEVA—AGRRMNRTTRRRIE 73

EFR95520

WP_003723 650 MKNP-YTIGLDIGTNSVGWAVLTNQYDLVKRKMKVAGNSDKKQIKKNFWGVRLFDDGQTA—VDRRMNRTARRRIE 73

WP_003727705 MKNP-YTIGLDIGTNSVGWAVLTDQYDLVKRKMKVAGNSDKKQIKKNFWGVRLFDDGQTA—VDRRMNRTARRRIE 73

WP_003730785 MKNP-YTIGLDIGTNSVGWAVLTDQYDLVKRKMKVAGNSDKKQIKKNFWGVRLFDDGQTA—VDRRMNRTARRRIE 73

WP_003733029 MKKP-YTIGLDIGTNSVGWAVLTDQYDLVKRKMKISGDSEKKQIKKNFWGVRLFEKGETA—AKRRMSRTARRRIE 73

WP_003739838 MKNP-YTIGLDIGTNSVGWAVLTDQYDLVKRKMKVAGNSDKKQIKKNFWGVRLFDEGETA—ADRRMNRTARRRIE 73

WP_014601172 MKNP-YTIGLDIGTNSVGWAVLTNQYDLVKRKMKVAGNSDKKQIKKNFWGVRLFDDGQTA—VDRRMNRTARRRIE 73

WP_023548323 MKNP-YTIGLDIGTNSVGWAVLTNQYDLVKRKMKVAGNSDKKQIKKNFWGVRLFDDGQTA—VDRRMNRTARRRIE 73

WP_031665337 MKNP-YTIGLDIGTNSVGWAVLTDQYDLVKRKMKVAGNSDKKQIKKNFWGVRLFDDGQTA—VDRRMNRTARRRIE 73

WP_031669209 MKKP-YTIGLDIGTNSVGWAVLTDQYDLVKRKMKISGDSEKKQIKKNFWGVRLFEKGETA—AKRRMSRTARRRIE 73

WP_033920898 MKNP-YTIGLDIGTNSVGWAVLTNQYDLVKRKMKVAGNSDKKQIKKNFWGVRLFDDGQTA—VDRRMNRTARRRIE 73

AKI42028 MKNP-YTIGLDIGTNSVGWAVLTNQYDLVKRKMKVAGNSDKKQIKKNFWGVRLFDDGQTA—VDRRMNRTARRRIE 76

AKI50529 MKNP-YTIGLDIGTNSVGWAVLTNQYDLVKRKMKVAGNSDKKQIKKNFWGVRLFDDGQTA—VDRRMNRTARRRIE 76

EFR83390

WP_046323 366 MKKP-YTIGLDIGTNSVGWAALTDQYDLVKRKMKVAGNSEKKQIKKNLWGVRLVDEGKTA—AHRRVNRTTRRRIE 73

AKE81011 ADKK-YSIGLDIGTNSVGWAVITDEYKVPSKKFKVLGNTDRHSIKKNLIGALLFDSGETA—EATRLKRTARRRYT 89

CU082355 I-VD-YCIGLDLGTGSVGWAWDMNHRLMKRN GKHLWGSRLFSNAETA—ATRRSSRSIRRRYN 64

WP_033162 KDIR-YSIGLDIGTNSVGWAVMDEHYELLKKG NHHMWGSRLFDAAEPA—ATRRASRSIRRRYN 65

AGZ 01981 ADKK-YSIGLDIGTNSVGWAVITDEYKVPSKKFKVLGNTDRHSIKKNLIGALLFDSGETA—EATRLKRTARRRYT 106

AKA60242 MDKK-YSIGLAIGTNSVGWAVITDEYKVPSKKFKVLGNTDRHSIKKNLIGALLFDSGETA—EATRLKRTARRRYT 73

AKS40380 MDKK-YSIGLDIGTNSVGWAVITDEYKVPSKKFKVLGNTDRHSIKKNLIGALLFDSGETA—EATRLKRTARRRYT 73

4UN5 B MDKK-YSIGLAIGTNSVGWAVITDEYKVPSKKFKVLGNTDRHSIKKNLIGALLFDSGETA—EATRLKRTARRRYT 77

WP_010922251 74 RRKNRICYLQEI FSNEMAKVDDSFFHRLEE-SFLV- H ERHPIFGN[I]V-DEVAYHEKYPTIY|H|LRKKLV 143

WP_039695303 75 RRKNRLRYLQEIFANEIAKVDESFFQRLDE-SFLT- F DSHPIFGNKA-EEDAYHQKFPTIYHLRKHLA 144

WP_045635197 74 RRKNRLRYLQEIFSEEMSKVDSSFFHRLDD-SFLI- E SKYPIFATLT-EEKEYHKQFPTIYHLRKQLA 143

5AXW_A 62 RRRHRIQRVKKLLFD YNLLTDhSELS G —NPYEARVK GLSQKLS 104

WP_0098806 83

WP_010922251 74 RRKNRI CYLQEI FSNEMAKVDDS FFHRLEE- SFLV- EEDKK H ERHPIFGNIV- ^■DEVAYHEKYPTIYHLRKKLV 143

WP_011054416 74 RRKNRICYLQEI FSNEMAKVDDSFFHRLEE- SFLV- EEDKK H ERHPIFGNIV- ^■DEVAYHEKYPTIYHLRKKLA 143

WP_011284745 74 RRKNRICYLQEI FSNEMAKVDDSFFHRLEE- SFLV- EEDKK H ERHPIFGNIV- ^■DEVAYHEKYPTIYHLRKKLV 143

WP_011285506 74 RRKNRICYLQEI FSNEMAKVDDSFFHRLEE- SFLV- EEDKK H ERHPIFGNIV- ^■DEVAYHEKYPTIYHLRKKLV 143

WP_011527619 74 RRKNRICYLQEI FSNEMAKVDDSFFHRLEE- SFLV- EEDKK H ERHPIFGNIV- ^■DEVAYHEKYPTIYHLRKKLV 143

WP_012560673 74 RRKNRICYLQEI FSNEIAKVDDSFFHRLEE- SFLV- EEDKK H ERHPIFGNIV- ^■DEVAYHEKYPTIYHLRKKLA 143

WP_014407541 74 RRKNRICYLQEI FSNEMAKVDDSFFHRLEE- SFLV- EEDKK H ERHPIFGNIV- ^■DEVAYHEKYPTIYHLRKKLA 143

WP_020905136 74 RRKNRICYLQEI FSNEMAKVDDSFFHRLEE- SFLV- EEDKK H ERHPIFGNIV- ^■DEVAYHEKYPTIYHLRKKLV 143

WP_023080005 74 RRKNRICYLQEI FSNEMAKVDDSFFHRLEE- SFLV- EEDKK H ERHPIFGNIV- ^■DEVAYHEKYPTIYHLRKKLA 143

WP_023610282 74 RRKNRICYLQEI FSNEMAKVDDSFFHRLEE- SFLV- EEDKK H ERHPIFGNIV- ^■DEVAYHEKYPTIYHLRKKLA 143

WP_030125963 74 RRKNRICYLQEI FSNEMAKVDDSFFHRLEE- SFLV- EEDKK H ERHPIFGNIV- ^■DEVAYHEKYPTIYHLRKKLV 143

WP_030126706 74 RRKNRICYLQEI FSNEMAKVDDSFFHRLEE- SFLV- EEDKK H ERHPIFGNIV- ^■DEVAYHEKYPTIYHLRKKLA 143

WP_031488318 74 RRKNRICYLQEI FSNEMAKVDDSFFHRLEE- SFLV- EEDKK H ERHPIFGNIV- ^■DEVAYHEKYPTIYHLRKKLA 143

WP_032460140 74 RRKNRICYLQEI FSNEIAKVDDSFFHRLEE- SFLV- EEDKK H ERHPIFGNIV- ^■DEVAYHEKYPTIYHLRKKLA 143

WP_032461047 74 RRKNRICYLQEI FSNEIAKVDDSFFHRLEE- SFLV- EEDKK H ERHPIFGNIV- ^■DEVAYHEKYPTIYHLRKKLA 143

WP_032462016 74 RRKNRICYLQEI FSNEMAKVDDSFFHRLEE- SFLV- EEDKK H ERHPIFGNIV- ^■DEVAYHEKYPTIYHLRKKLV 143

WP_032462936 74 RRKNRICYLQEI FSNEMAKVDDSFFHRLEE- SFLV- EEDKK H ERHPIFGNIV- ^■DEVAYHEKYPTIYHLRKKLA 143

WP_032464890 74 RRKNRICYLQEI FSNEMAKVDDSFFHRLEE- SFLV- EEDKK H ERHPIFGNIV- ^■DEVAYHEKYPTIYHLRKKLV 143

WP_033888930

WP_038431314 74 RRKNRICYLQEI FSNEMAKVDDSFFHRLEE-SFLV—EEDKK- H ERHPIFGNIV-DEVAYHEKYPTIYHLRKKLA 143

WP_038432938 74 RRKNRICYLQEI FSNEMAKVDDSFFHRLEE-SFLV—EEDKK- H ERHPIFGNIV-DEVAYHEKYPTIYHLRKKLA 143

WP_038434062 74 RRKNRICYLQEI FSNEMAKVDDSFFHRLEE-SFLV—EEDKK- H ERHPIFGNIV-DEVAYHEKYPTIYHLRKKLA 143

BAQ51233 1 MAKVDDSFFHRLEE-SFLV—EEDKK- H ERHPIFGNIV-DEVAYHEKYPTIYHLRKKLV 54

KGE60162

KGE60856

WP_0029899 55 74 RRKNRICYLQEI FSNEMAKVDDSFFHRLEE- SFLV—EEDKK- H ERHPIFGNIV- -DEVAYHEKYPTIYHLRKKLV 143

WP_003030002 74 RRRNRLRYLQEI FAEEMNKVDENFFQRLDD- SFLV—DEDKR- G ERHPIFGNIA- ^■AEVKYHDDFPTIYHLRKHLA 143

WP_003065552 75 RRKNRLRYLQEI FAEEMTKVDESFFQRLDE- SFLRwdDDNKK- L GRYPIFGNKA- ^■DWKYHQEFPTIYHLRKHLA 146

WP_001040076 74 RRRNRILYLQEI FAEEMSKVDDSFFHRLED- SFLV—EEDKR- G SKYPIFATLQ- ^■EEKYYHEKFPTIYHLRKELA 143

WP_001040078 74 RRRNRILYLQEI FAEEMSKVDDSFFHRLED- SFLV—EEDKR- G SKYPIFATLQ- ^■EEKDYHEKFPTIYHLRKELA 143

WP_001040080 74 RRRNRILYLQEI FAEEMSKVDDSFFHRLED- SFLV—EEDKR- G SKYPIFATLQ- ^■EEKDYHEKFSTIYHLRKELA 143

WP_001040081 74 RRRNRILYLQEI FAEEMSKVDDSFFHRLED- SFLV—EEDKR- G SKYPIFATLQ- ^■EEKDYHEKFSTIYHLRKELA 143

WP_001040083 74 RRRNRILYLQEI FAEEMSKVDDSFFHRLED- SFLV—EEDKR- G SKYPIFATLQ- ^■EEKDYHEKFSTIYHLRKELA 143

WP 001040085 74 RRRNRILYLQEI FAEEMSKVDDSFFHRLED- SFLV—EEDKR- G SKYPIFATLQ- ^■EEKDYHEKFSTIYHLRKELA 143

WP 001040087 74 RRRNRILYLQEIFAEEMSKVDDSFFHRLED- SFLV--EEDKR- G SKYPIFATLQ-^■EEKDYHEKFSTIYHLRKELA 143

WP 001040088 74 RRRNRILYLQEIFAEEMSKVDDSFFHRLED- SFLV- -EEDKR- G SKYPIFATLQ- ^■EEKDYHEKFSTIYHLRKELA 143

WP 001040089 74 RRRNRILYLQEIFAEEMSKVDDSFFHRLED- SFLV- -EEDKR- G SKYPIFATLQ- ^■EEKDYHEKFSTIYHLRKELA 143

WP 001040090 74 RRRNRILYLQEIFAEEMSKVDDSFFHRLED- SFLV- -EEDKR- G SKYPIFATLQ- ^■EEKDYHEKFSTIYHLRKELA 143

WP 001040091 74 RRRNRILYLQEIFAEEMSKVDDSFFHRLED- SFLV- -EEDKR- G SKYPIFATLQ- ^■EEKDYHEKFSTIYHLRKELA 143

WP 001040092 74 RRRNRILYLQEIFAEEMSKVDDSFFHRLED- SFLV- -EEDKR- G SKYPIFATMQ- ^■EEKDYHEKFPTIYHLRKELA 143

WP 001040094 74 RRRNRILYLQEIFAEEMSKVDDSFFHRLED- SFLV- -EEDKR- G SKYPIFATMQ- ^■EEKYYHEKFPTIYHLRKELA 143

WP 001040095 74 RRRNRILYLQEIFAEEMSKVDDSFFHRLED- SFLV- -EEDKR- G SKYPIFATMQ- ^■EEKYYHEKFPTIYHLRKELA 143

WP 001040096 74 RRRNRILYLQEIFAEEMSKVDDSFFHRLED- SFLV- -EEDKR- G SKYPIFATMQ- ^■EEKYYHEKFPTIYHLRKELA 143

WP 001040097 74 RRRNRILYLQEIFAEEMSKVDDSFFHRLED- SFLV- -EEDKR- G SKYPIFATMQ- ^■EEKYYHEKFPTIYHLRKELA 143

WP 001040098 74 RRRNRILYLQEIFAEEMSKVDDSFFHRLED- SFLV- -EEDKR- G SKYPIFATMQ- ^■EEKYYHEKFPTIYHLRKELA 143

WP 001040099 74 RRRNRILYLQEIFAEEMSKVDDSFFHRLED- SFLV- -EEDKR- G SKYPIFATMQ- ^■EEKYYHEKFPTIYHLRKELA 143

WP 001040100 74 RRRNRILYLQEIFAEEMSKVDDSFFHRLED- SFLV- -EEDKR- G SKYPIFATMQ- ^■EEKYYHEKFPTIYHLRKELA 143

WP 001040104 74 RRRNRILYLQEIFAEEMSKVDDSFFHRLED- SFLV- -EEDKR- G SKYXIFATLQ- ^■EEKDYHEKFSTIYHLRKELA 143

WP 001040105 74 RRRNRILYLQEIFAEEMSKVDDSFFHRLED- SFLV- -EEDKR- G SKYPIFATLQ- ^■EEKDYHEKFSTIYHLRKELA 143

WP 001040106 74 CRRNRILYLQEIFAEEMSKVDDSFFHRLED- SFLV- -EDDKR- G SKYPIFATMQ- ^■EEKDYHEKFPTIYHLRKELA 143

WP 001040107 74 RRRNRILYLQEIFAEEMSKVDDSFFHRLED- SFLV- -EDDKR- G SKYPIFATMQ- ^■EEKDYHEKFPTIYHLRKELA 143

WP 001040108 74 RRRNRILYLQEIFAEEMSKVDDSFFHRLED- SFLV- -EDDKR- G SKYPIFATMQ- ^■EEKDYHEKFPTIYHLRKELA 143

WP 001040109 74 RRRNRILYLQEIFAEEMSKVDDSFFHRLED- SFLV- -EDDKR- G SKYPIFATMQ- ^■EEKDYHEKFPTIYHLRKELA 143

WP 001040110 74 RRRNRILYLQEIFAEEMSKVDDSFFHRLED- SFLV- -EDDKR- G SKYPIFATMQ- ^■EEKDYHEKFPTIYHLRKELA 143

WP 015058523 74 RRRNRILYLQEIFAEEMSKVDDSFFHRLED- SFLV- -EEDKR- G SKYPIFATMQ- ^■EEKDYHEKFPTIYHLRKELA 143

WP 017643650 74 RRRNRILYLQEIFAEEMSKVDDSFFHRLED- SFLV- -EEDKR- G SKYPIFATMQ- ^■EEKYYHEKFPTIYHLRKELA 143

WP 017647151 74 RRRNRILYLQEIFAEEMSKVDDSFFHRLED- SFLV- -EDDKR- G SKYPIFATMQ- ^■EEKDYHEKFPTIYHLRKELA 143

WP 017648376 74 RRRNRILYLQEIFAEEMSKVDDSFFHRLED- SFLV- -EDDKR- G SKYPIFATMQ- ^■EEKDYHEKFPTIYHLRKELA 143

WP 017649527 74 RRRNRILYLQEIFAEEMSKVDDSFFHRLED- SFLV- -EEDKR- G SKYPIFATLQ- ^■EEKDYHEKFPTIYHLRKELA 143

WP 017771611 74 RRRNRILYLQEIFAEEMSKVDDSFFHRLED- SFLV- -EDDKR- G SKYPIFATMQ- ^■EEKDYHEKFPTIYHLRKELA 143

WP 017771984 74 RRRNRILYLQEIFAEEMSKVDDSFFHRLED- SFLV- -EEDKR- G SKYPIFATLQ- ^■EEKDYHEKFSTIYHLRKELA 143

CFQ25032 74 RRRNRILYLQEIFAEEMSKVDDSFFHRLED- SFLV- -EEDKR- G SKYPIFATLQ- ^■EEKDYHEKFSTIYHLRKELA 143

CFV16040 74 RRRNRILYLQEIFAEEMSKVDDSFFHRLED- SFLV- -EEDKR- G SKYPIFATLQ- ^■EEKDYHEKFSTIYHLRKELA 143

KLJ37842 74 RRRNRILYLQEIFAEEMSKVDDSFFHRLED- SFLV- -EEDKR- G SKYPIFATLQ- ^■EEKDYHEKFSTIYHLRKELA 143

KLJ72361 74 RRRNRILYLQEIFAEEMSKVDDSFFHRLED- SFLV- -EEDKR- G SKYPIFATLQ- ^■EEKDYHEKFSTIYHLRKELA 143

KLL20707 74 RRRNRILYLQEIFAEEMSKVDDSFFHRLED- SFLV- -EEDKR- G SKYPIFATLQ- ^■EEKDYHEKFSTIYHLRKELA 143

KLL42645 74 RRRNRILYLQEIFAEEMSKVDDSFFHRLED- SFLV- -EDDKR- G SKYPIFATMQ- ^■EEKDYHEKFPTIYHLRKELA 143

WP 047207273 74 RRRNRILYLQEIFAEEMSKVDDSFFHRLED- SFLV- -EEDKR- G SKYPIFATLQ- ^■EEKDYHEKFSTIYHLRKELA 143

WP 047209694 74 RRRNRILYLQEIFAEEMSKVDDSFFHRLED- SFLV- -EEDKR- G SKYPIFATMQ- ^■EEKYYHEKFPTIYHLRKELA 143

WP 050198062 74 RRRNRILYLQEIFAEEMSKVDDSFFHRLED- SFLV- -EEDKR- G SKYPIFATLQ- ^■EEKDYHEKFSTIYHLRKELA 143

WP 050201642 74 RRRNRILYLQEIFAEEMSKVDDSFFHRLED- SFLV- -EEDKR- G SKYPIFATLQ- ^■EEKDYHEKFSTIYHLRKELA 143

WP 050204027 74 RRRNRILYLQEIFAEEMSKVDDSFFHRLED- SFLV- -EDDKR- G SKYPIFATMQ- ^■EEKDYHEKFPTIYHLRKELA 143

WP 050881965 74 RRRNRILYLQEIFAEEMSKVDDSFFHRLED- SFLV- -EEDKR- G SKYPIFATLQ- ^■EEKDYHEKFSTIYHLRKELA 143

WP 050886065 74 RRRNRILYLQEIFAEEMSKVDDSFFHRLED- SFLV--EEDKR- G SKYPIFATLQ-EEKDYHEKFSTIYHLRKELA 143

AHN30376 74 RRRNRILYLQEIFAEEMSKVDDSFFHRLED- SFLV- -EEDKR- G SKYPIFATMQ-EEKDYHEKFPTIYHLRKELA 143

EA078426 74 RRRNRILYLQEIFAEEMSKVDDSFFHRLED- SFLV- -EEDKR- G SKYPIFATLQ-EEKDYHEKFSTIYHLRKELA 143

CCW42055 74 RRRNRILYLQEIFAEKMSKVDDSFFHRLED- SFLV- -EEDKR- G SKYPIFATLQ-EEKDYHEKFPTIYHLRKELA 143

WP 0030415 02 74 RRRNRLRYLQEIFAEEMMQVDESFFQRLDD- SFLV- -DEDKR- G ERHPI FGNIA-AEVKYHDEFPTIYHLRKHLA 143

WP 0375937 52 75 RRKNRLRYLQEI FTEEMNKVDENFFQRLDD- SFLV- -EEDKQ- G SKYPIFGTLK-EEKEYHKKFKTIYHLREELA 144

WP 0495166 84 75 RRRNRLRYLQEIFAEEMMQVDESFFQRLDD- SFLV- -EEDKR- G SRYPI FGNIA-AEVKYHDDFPTIYHLRKHLV 144

GAD46167 74 RRKNRLRYLQEI FTEEMNKVDENFFQRLDD- SFLV- -EEDKQ- G SKYPIFGTLK-EEKEYHKKFKTIYHLREELA 143

WP 0183634 70 75 RRKNRLRYLQDIFTEEMAKVDDSFFQRLDE- SFLT- -DNDKN- F DSHPIFGNKA-EEDAYHQKFPTIYHLRKHLA 144

WP 0030438 19 74 RRKNRIRYLQEIFANEMAKLDDSFFQRLEE- SFLV- -EEDKK- -N ERHPIFGNLA-DEVAYHRNYPTIYHLRKKLA 143

WP 0062696 58 74 RRKNRLRYLQEI FTGEMNKVDENFFQRLDD- SFLV- -DEDKR- G EHHPIFGNIA-AEVKYHDDFPTIYHLRRHLA 143

WP 0488008 89 74 RRKNRLRYLQEIFIEEMNKVDENFFQRLDD- SFLV- -TEDKR- G SKYPIFGTLK-EEKEYYKEFETIYHLRKRLA 143

WP 0127671 06 74 RRKNRIRYLQEIFSSEMSKVDDSFFHRLEE- SFLV- -EEDKK- H ERHPIFGNIV-DEVAYHEKYPTIYHLRKKLA 143

WP 0146123 33 74 RRKNRIRYLQEIFSSEMSKVDDSFFHRLEE- SFLV- -EEDKK- H ERHPIFGNIV-DEVAYHEKYPTIYHLRKKLA 143

WP 0150170 95 74 RRKNRIRYLQEIFSSEMSKVDDSFFHRLEE- SFLV- -EEDKK- H ERHPIFGNIV-DEVAYHEKYPTIYHLRKKLA 143

WP 0150576 49 74 RRKNRIRYLQEIFSSEMSKVDDSFFHRLEE- SFLV- -EEDKK- H ERHPIFGNIV-DEVAYHEKYPTIYHLRKKLA 143

WP 0483272 15 74 RRKNRIRYLQEIFSSEMSKVDDSFFHRLEE- SFLV- -EEDKK- H ERHPIFGNIV-DEVAYHEKYPTIYHLRKKLA 143

WP 0495193 24 74 RRKNRIRYLQEIFSSEMSKVDDSFFHRLEE- SFLV- -EEDKK- H ERHPIFGNIV-DEVAYHEKYPTIYHLRKKLA 143

WP 0125159 31 74 RRKNRLRYLKEI FTEEMAKVDDGFFQRLED- SFYV- -LEDKE- G NKHPIFANLA-DEVAYHKKYPTIYHLRKELV 143

WP 0213209 64 74 RRKNRLRYLKEI FTEEMAKVDDGFFQRLED- SFYV- -LEDKE- G NKHPIFANLA-DEVAYHKKYPTIYHLRKELV 143

WP 0375817 60 74 RRKNRLRFLKEI FTEEMAKVDDGFFQRLED- SFYV- -LEDKE- G NKHPIFANLA-DEVAYHKKYPTIYHLRKELV 143

WP 0042324 81 74 RRKNRLRYLQEIFAKEMAKVDESFFQRLEE- SFLT- -DDDKT- F DSHPIFGNKA-EEDTYHQEFPTIYHLRKHLA 143

WP 0098545 40 75 RRKNRLRYLQEIFAEEMTKVDESFFYRLDE- SFLT- -TDEKD- F ERHPIFGNKA-EEDAYHQKFPTIYHLRNYLA 144

WP 0129621 74 75 RRKNRLRYLQEIFAEEMAKVDESFFYRLDE- SFLT- -TDDKD- F ERHPIFGNKA-DEIKYHQEFPTIYHLRKHLA 144

WP 0396953 03 75 RRKNRLRYLQEIFANEIAKVDESFFQRLDE- SFLT- -DDDKT- F DSHPIFGNKA-EEDAYHQKFPTIYHLRKHLA 144

WP 0143349 83 74 RRKNRLRYLQEIFAKEMTKVDESFFQRLEE- SFLT- -DDDKT- F DSHPIFGNKA-EEDAYHQKFPTIYHLRKYLA 143

WP 0030992 69 74 RRKYRIKELQKIFSSEMNELDIAFFPRLSE- SFLV- -SDDKE- F ENHPIFGNLK-DEITYHNDYPTIYHLRQTLA 143

AHY15608 74 RRKYRIKELQKIFSSEMNELDIAFFPRLSE- SFLV- -SDDKE- F ENHPIFGNLK-DEITYHNDYPTIYHLRQTLA 143

AHY17476 74 RRKYRIKELQKIFSSEMNELDIAFFPRLSE- SFLV- -SDDKE- F ENHPIFGNLK-DEITYHNDYPTIYHLRQTLA 143

ESR09100

AGM98575 74 RRKYRIKELQKIFSSEMNELDIAFFPRLSE- SFLV- -SDDKE- F ENHPIFGNLK- ^■DEITYHNDYPTIYHLRQTLA 143

ALF27331 74 RRRNRILYLQEIFSEEMGKVDDSFFHRLED- SFLV- -TEDKR- G ERHPIFGNLE- ^■EEVKYHENFPTIYHLRQYLA 143

WP 0183724 92 74 RRRNRIRYLQHIFAEEMNRADENFFHRLKE- SFFV- -EEDKT- Y SKYPIFGTLE- ^■EEKNYHKNYPTIYHLRKTLA 143

WP 0456180 28 75 RRKNRLRYLQEI FTEEMSKVDI SFFHRLDD- SFLV- -PEDKR- G SKYPIFATLE- ^■EEKEYHKNFPTIYHLRKHLA 144

WP 0456351 97 74 RRKNRLRYLQEIFSEEMSKVDSSFFHRLDD- SFLI- -PEDKR- E SKYPIFATLT- ^■EEKEYHKQFPTIYHLRKQLA 143

WP 0022635 49 74 RRRNRILYLQEIFSEEMGKVDDSFFHRLED- SFLV- -TEDKR- G ERHPIFGNLE- ^■EEVKYHENFPTIYHLRQYLA 143

WP 0022638 87 74 RRRNRILYLQEIFSEEMGKVDDSFFHRLED- SFLV- -TEDKR- G ERHPIFGNLE- ^■EEVKYHENFPTIYHLRQYLA 143

WP 0022649 20 74 RRRNRILYLQEIFSEEMGKVDDSFFHRLDE- SFLT- -DDDKN- F DSYPIFGNKA- ^■EEDAYHQKFPTIYHLRKHLA 143

WP 0022690 43 74 RRRNRILYLQEIFSEEMGKVDDSFFHRLED- SFLV- -TEDKR- G ERHPIFGNLE- ^■EEVKYHENFPTIYHLRQYLA 143

WP 002269448 74 RRRNRILYLQEIFSEEMGKVDDSFFHRLED- SFLV--TEDKR- G ERHPIFGNLE-^■EEVKYHENFPTIYHLRQYLA 143

WP ^"0022 71977 74 RRRNRILYLQEIFSEEMGKVDDSFFHRLED- SFLV- -TEDKR- G ERHPIFGNLE- ^■EEVKYHENFPTIYHLRQYLA 143

WP ^"0022 72766 74 RRRNRILYLQEIFSEEMGKVDDSFFHRLED- SFLV- -TEDKR- G ERHPIFGNLE- ^■EEVKYHENFPTIYHLRQYLA 143

WP ^"0022 73241 74 RRRNRILYLQEIFSEEMGKVDDSFFHRLED- SFLV- -TEDKR- G ERHPIFGNLE- ^■EEVKYHENFPTIYHLRQYLA 143

WP ^"0022 75430 74 RRRNRILYLQEIFAEEMSKVDDSFFHRLED- SFLV- -TEDKR- G ERHPIFGNLE- ^■EEVKYHENFPTIYHLRQYLA 143

WP ^"0022 76448 74 RRRNRILYLQEIFSEEMGKVDDSFFHRLED- SFLV- -TEDKR- G ERHPIFGNLE- ^■EEVKYHENFPTIYHLRQYLA 143

WP ^"0022 77050 74 RRRNRILYLQEIFSEEMGKVDDSFFHRLDE- SFLT- -DDDKN- F DSHPIFGNKA- ^■EEDAYHQKFPTIYHLRKHLA 143

WP ^"0022 77364 74 RRRNRILYLQEIFAEEMSKVDDSFFHRLED- SFLV- -TEDKR- G ERHPIFGNLE- ^■EEVKYHENFPTIYHLRQYLA 143

WP ^"0022 79025 74 RRRNRILYLQEIFSEEMGKVDDSFFHRLED- FFLV- -TEDKR- G ERHPIFGNLE- ^■EEVKYHENFPTIYHLRQYLA 143

WP ^"0022 79859 74 RRRNRILYLQEIFSEEMGKVDDSFFHRLDE- SFLT- -DDDKN- F DSHPIFGNKA- ^■EEDAYHQKFPTIYHLRKHLA 143

WP ^"0022 80230 74 RRRNRILYLQEIFAEEMSKVDDSFFHRLED- SFLV- -TEDKR- G ERHPIFGNLE- ^■EEVKYHENFPTIYHLRQYLA 143

WP ^"0022 81696 74 RRRNRILYLQEIFAEEMSKVDDSFFHRLED- SFLV- -TEDKR- G ERHPIFGNLE- ^■EEVKYHENFPTIYHLRQYLA 143

WP ^"0022 82247 74 RRRNRILYLQEIFAEEMSKVDDSFFHRLDE- SFLT- -DDDKN- F DSHPIFGNKA- ^■EEDAYHQKFPTIYHLRKHLA 143

WP ^"0022 82906 74 RRRNRILYLQEIFSEEMGKVDDSFFHRLED- SFLV- -TEDKR- G ERHPIFGNLE- ^■EEVKYHENFPTIYHLRQYLA 143

WP ^"0022 83846 74 RRRNRILYLQEIFSEEMGKVDDSFFHRLED- SFLV- -TEDKR- G ERHPIFGNLE- ^■EEVKYHENFPTIYHLRQYLA 143

WP ^"0022 87255 74 RRRNRILYLQEIFAEEMSKVDDSFFHRLED- SFLV- -TEDKR- G ERHPIFGNLE- ^■EEVKYHENFPTIYHLRQYLA 143

WP ^"0022 88990 74 RRRNRILYLQEIFSEEMGKVDDSFFHRLED- SFLV- -TEDKR- G ERHPIFGNLE- ^■EEVKYHENFPTIYHLRQYLA 143

WP ^"0022 89641 74 RRRNRILYLQEIFSEEMGKVDDSFFHRLED- SFLV- -TEDKR- G ERHPIFGNLE- ^■EEVKYHENFPTIYHLRQYLA 143

WP ^"0022 90427 74 RRRNRILYLQEIFSEEMGKVDDSFFHRLED- SFLV- -TEDKR- G ERHPIFGNLE- ^■EEVKYHENFPTIYHLRQYLA 143

WP ^"0022 95753 74 RRRNRILYLQEIFSEEMGKVNDSFFHRLED- SFLV- -TEDKR- G ERHPIFGNLE- ^■EEVKYHENFPTIYHLRQYLA 143

WP ^"0022 96423 74 RRRNRILYLQEIFSEEMGKVDDSFFHRLED- SFLV- -TEDKR- G ERHPIFGNLE- ^■EEVKYHENFPTIYHLRQYLA 143

WP ^"0023 04487 74 RRRNRILYLQEIFAEEMMQVDESFFQRLDD- SFLV- -EEDKR- G SRYPIFGTLK- ^■EEKKYHKEFKTIYHLREKLA 143

WP ^"0023 05844 74 RRRNRILYLQEIFSEEMDKVDDSFFHRLED- SFLV- -TEDKR- G ERHPIFGNLE- ^■EEVKYHENFPTIYHLRQYLA 143

WP ^"0023 07203 74 RRRNRILYLQEIFSEEMGKVDDSFFHRLED- SFLV- -TEDKR- G ERHPIFGNLE- ^■EEVKYHENFPTIYHLRQYLA 143

WP ^"0023 10390 74 RRRNRILYLQEIFSEEMGKVDDSFFHRLED- SFLV- -TEDKR- G ERHPIFGNLE- ^■EEVKYHENFPTIYHLRQYLA 143

WP ^"0023 52408 74 RRRNRILYLQEIFSEEMGKVDDSFFHRLED- SFLV- -TEDKR- G ERHPIFGNLE- ^■EEVKYHENFPTIYHLRQYLA 143

WP ^"0129 97688 74 RRRNRILYLQEIFAEEMSKVDDSFFHRLED- SFLV- -TEDKR- G ERHPIFGNLE- ^■EEVKYHENFPTIYHLRQYLA 143

WP ^"θ146 77909 74 RRRNRILYLQEIFSEEMGKVDDSFFHRLED- SFLV- -TEDKR- G ERHPIFGNLE- ^■EEVKYHENFPTIYHLRQYLA 143

WP ^"0193 12892 74 RRRNRILYLQEIFAEEMSKVDDSFFHRLED- SFLV- -TEDKR- G ERHPIFGNLE- ^■EEVKYHENFPTIYHLRQYLA 143

WP ^"0193 13659 74 RRRNRILYLQEIFSEEMGKVDDSFFHRLED- SFLV- -TEDKR- G ERHPIFGNLE- ^■EEVKYHENFPTIYHLRQYLA 143

WP ^"0193 14093 74 RRRNRILYLQEIFSEEMGKVDDSFFHRLED- SFLV- -TEDKR- G ERHPIFGNLE- ^■EEVKYHENFPTIYHLRQYLA 143

WP ^"0193 15370 74 RRRNRILYLQEIFSEEMGKVDDSFFHRLED- SFLV- -TEDKR- G ECHPIFGNLE- ^■EEVKYHENFPTIYHLRQYLA 143

WP ^"0198 03776 74 RRRNRILYLQEIFSEEMGKVDDSFFHRLED- SFLV- -TEDKR- G ERHPIFGNLE- ^■EEVKYHENFPTIYHLRQYLA 143

WP ^"0198 05234 74 RRRNRILYLQEIFSEEMGKVDDSFFHRLED- SFLV- -TEDKR- G ERHPIFGNLE- ^■EEVKYHENFPTIYHLRQYLA 143

WP ^"0247 83594 74 RRRNRILYLQEIFSEEMGKVDDSFFHRLED- SFLV- -TEDKR- G ERHPIFGNLE- ^■EEVKYHENFPTIYHLRQYLA 143

WP ^"0247 84288 74 RRRNRILYLQEIFAEEMSKVDDSFFHRLDE- SFLT- -DDDKN- F DSHPIFGNKA- ^■EEDAYHQKFPTIYHLRKHLA 143

WP ^"0247 84666 74 RRRNRILYLQEIFAEEMSKVDDSFFHRLED- SFLV- -TEDKR- G ERHPIFGNLE- ^■EEVKYHENFPTIYHLRQYLA 143

WP ^"0247 84894 74 RRRNRILYLQEIFSEEMGKVDDSFFHRLED- SFLV- -TEDKR- G ERHPIFGNLE- ^■EEVKYHENFPTIYHLRQYLA 143

WP ^"0247 86433 74 RRRNRILYLQEIFAEEMNKVDDSFFHRLDE- SFLT- -DDDKN- F DSHPIFGNKA- ^■EEDAYHQKFPTIYHLRKHLA 143

WP 049473442 74 RRRNRILYLQEIFAEEMSKVDDSFFHRLED- SFLV--^■TEDKR- ^■G ERHPIFGNLE-^■EEVKYYENFPTIYHLRQYLA 143

WP 049474547 74 RRRNRILYLQEIFSEEMGKVDDSFFHRLED- SFLV-- TEDKR- ^■G ERHPIFGNLE- ^■EEVKYHENFPTIYHLRQYLA 143

EMC03581 67 RRRNRILYLQEIFAEEMSKVDDSFFHRLED- SFLV-- TEDKR- ^■G ERHPIFGNLE- ^■EEVKYHENFPTIYHLRQYLA 136

WP 000428612 75 RRKNRLRYLQEIFAEEMSKVDSSFFHRLDD- ^■SFLI— PEDKK- ^■G SKYPIFATLI- ^■EEKEYHKQFPTIYHLRKQLA 144

WP 000428613 75 RRKNRLRYLQEIFAEEMSKVDSSFFHRLDD- ^■SFLI— PEDKR- ^■G SKYPIFATLA- ^■EEKEYHKQFPTIYHLRKQLA 144

WP 049523028 74 RRRNRILYLQEIFAAEMNKVDESFFHRLDD- SFLV-- ^■PEDKR- ^■G SKYPIFGTLE- ^■EEKEYHKQFPTIYYLRKILA 143

WP 003107102 43 RRINRIKYLQSIFDDEMSKIDSAFFQRIKD- SFLV-- PDDKN- ^■D DRHPIFGNIK- ^■DEVDYHKNYPTIYHLRKKLA 112

WP 054279288 76 RRKNRLCYLRDIFESEMHTIDKHFFLRLED- SFLH-- KSDKR- ^■Y EAHPIFGTLQ- ^■EEKAYHDNYPTIYHLRKALA 145

WP 049531101 75 RRKNRLRYLQEIFSEEISKVDNSFFHRLDD- SFLV-- PEDKR- ^■G SKYPIFATLT- ^■EEKEYYKQFPTIYHLRKQLA 144

WP 049538452 75 RRKNRLRYLQEIFAEEMNKVDSSFFHRLDD- SFLV-- PEDKR- ^■G SKYPIFATLA- ^■EEKEYHKNFPTIYHLRKQLA 144

WP 049549711 75 RRKNRLRYLQEIFSGEMSKVDSSFFHRLDD- SFLV-- ^■PEDKR- ^■G SKYPIFATLV- ^■EEKEYHKQFPTIYHLRKQLA 144

WP 007896501 76 RRRYRLCQLQNIFATEMVKVDDTFFQRLSE- SFFY-- YQDKA- F DKHPIFGNSK- ^■EERAYHKTYPTIYHLRKDLA 145

EFR44625 28 RRRYRLCQLQNIFATEMVKVDDTFFQRLSE- SFFY-- YQDKA- F DKHPIFGNSK- ^■EERAYHKTYPTIYHLRKDLA 97

WP 002897477 74 RRRNRILYLQEIFTESMNEIDESFFHRLDD- SFLV-- PEDKR- ^■G SKYPIFATLQ- ^■EEKEYHKQFPTIYHLRKQLA 143

WP 002906454 74 RRKNRLRYLQEIFSEEISKLDSSFFHRLDD- SFLV-- PEDKR- ^■G SKYPIFATLE- ^■EEKEYHKKFPTIYHLRKHLA 143

WP 009729476 75 RRKNRLRYLQEIFSEEIGKVDSSFFHRLDD- ^■SFLI— PEDKR- ^■G SKYPIFATLA- ^■EEKKYHKQFPTIYHLRKQLA 144

CQR24647 74 RRRNRILYLQDIFSPELNQVDESFLHRLDD- SFLVa- -EDKR- ^■G ERHVIFGNIA- ^■DEVKYHKEFPTIYHLRKHLA 143

WP 000066813 75 RRKNRLRYLQEIFSQEISKVDSSFFHRLDD- FFLV-- PEDKR- ^■G SKYPIFATLV- ^■EEKEYHKKFPTIYHLRKHLA 144

WP 009754323 75 RRKNRLRYLQEIFAEEMSKVDSSFFHRLDD- SFLV-- PEDKS- ^■G SKYPIFATLA- ^■EEKEYHKKFPTIYHLRKHLA 144

WP 044674937 74 RRRNRILYLQEIFAEEINKIDDSFFQRLDD- SFLIv- -EDKQ- ^■G SKHPIFGTLQ- ^■EEKKYHKQFPTIYHLRKQLA 143

WP 044676715 74 RRRNRILYLQEIFAEEINKIDDSFFQRLDD- SFLIv- ^■-EDKQ- ^■G SKHPIFGTLQ- ^■EEKEYHKQFPTIYHLRKQLA 143

WP 044680361 74 RRRNRILYLQEIFAEEINKIDDSFFQRLDD- SFLIv- -EDKQ- ^■G SKHPIFGTLQ- ^■EEKEYHKQFPTIYHLRKQLA 143

WP 044681799 74 RRRNRILYLQEIFAEEINKIDDSFFQRLDD- SFLIv- -EDKQ- ^■G SKHPIFGTLQ- ^■EEKKYHKQFPTIYHLRKQLA 143

WP 049533112 74 RRRNRLRYLQEI FAEEMNKVDENFFQRLDD- SFLV-- DEDKR- ^■G ERHPIFGNIA- ^■AEVKYHDDFPTIYHLRKHLA 143

WP 029090905 28 HRKFRLRLLEDMFEKEILSKDPSFFIRLKE- AFLSpkDEQKQ- F LFNDKDyTDADYYEQYKTIYHLRYDLI 100

WP 006506696 61 KRRERIRLLRAILQDMVLEKDPTFFIRLEHtSFLD-- ^■EEDKA: .G DNYNLFIDEDfNDYTYYHKYPTIYHLRKALC 139

AIT42264 74 RRKNRICYLQEIFSNEMAKVDDSFFHRLEE- SFLV-- EEDKK- ^■H ERHPIFGNIV- ^■DEVAYHEKYPTIYHLRKKLV 143

WP 034440723 73 RRRFRIRELQKIFDKSMGEVDSNFFHRLDE- SFLV-- EEDKE- ^■Y SKYPIFSNEK- ^■EDKNYYDKYPTIYHLRKDLA 142

AKQ21048 74 RRKNRICYLQEIFSNEMAKVDDSFFHRLEE- SFLV-- EEDKK- ^■H ERHPIFGNIV- ^■DEVAYHEKYPTIYHLRKKLV 143

WP 004636532 74 RRRNRLIYLQDIFQQPMLAIDENFFHRLDD- SFFV-- PDDKS- ^■Y DRHPIFGSLE- ^■EEVAYHNTYPTIYHLRKHLA 143

WP 002364836 74 RRRNRLRYLQAFFEEAMTDLDENFFARLQE- SFLV-- PEDKK- ^■w HRHPIFAKLE- ^■DEVAYHETYPTIYHLRKKLA 143

WP 016631044 25 RRRNRLRYLQAFFEEAMTDLDENFFARLQE- SFLV-- PEDKK- ^■w HRHPIFAKLE- ^■DEVAYHETYPTIYHLRKKLA 94

EMS75795

WP 002373311 74 RRRNRLRYLQAFFEEAMTDLDENFFARLQE- SFLV-- PEDKK- ^■W HRHPIFAKLE- ^■DEVAYHETYPTIYHLRKKLA 143

WP 002378009 74 RRRNRLRYLQAFFEEAMTALDENFFARLQE- SFLV-- PEDKK- ^■W HRHPIFAKLE- ^■DEVAYHETYPTIYHLRKKLA 143

WP 002407324 74 RRRNRLRYLQAFFEEAMTALDENFFARLQE- SFLV-- PEDKK- ^■W HRHPIFAKLE- ^■DEVAYHETYPTIYHLRKKLA 143

WP 002413717 74 RRRNRLRYLQAFFEEAMTDLDENFFARLQE- SFLV-- PEDKK- ^■W HRHPIFAKLE- ^■DEVAYHETYPTIYHLRKKLA 143

WP 010775580 74 RRRNRLRYLQAFFEEAMTALDENFFARLQE- SFLV-- PEDKK- ^■W HRHPIFAKLE- ^■DEVAYHETYPTIYHLRKKLA 143

WP 010818269 74 RRRNRLRYLQAFFEEAMTALDENFFARLQE- SFLV-- PEDKK- ^■W HRHPIFAKLE- ^■DEVAYHETYPTIYHLRKKLA 143

WP 010824395 74 RRRNRLRYLQAFFEEAMTDLDENFFARLQE- SFLV--PEDKK- ■w HRHPIFAKLE-^■DEVAYHETYPTIYHLRKKLA 143

WP ^"016622645 74 RRRNRLRYLQAFFEEAMTALDENFFARLQE- SFLV- -PEDKK- ■w HRHPIFAKLE- ^■DEVAYHETYPTIYHLRKKLA 143

WP ^"033624816 74 RRRNRLRYLQAFFEEAMTALDENFFARLQE- SFLV- -PEDKK- ■w HRHPIFAKLE- ^■DEVAYHETYPTIYHLRKKLA 143

WP ^"033625576 74 RRRNRLRYLQAFFEEAMTALDENFFARLQE- SFLV- -PEDKK- ■w HRHPIFAKLE- ^■DEVAYHETYPTIYHLRKKLA 143

WP ^"033789179 74 RRRNRLRYLQAFFEEAMTALDENFFARLQE- SFLV- -PEDKK- ■w HRHPIFAKLE- ^■DEVAYHETYPTIYHLRKKLA 143

WP ^"002310644 74 RRRQRILELQKIFAPEILKIDEHFFARLNE- SFLV- -LDEKK- Q SRHPVFATIK- ^■QEKSYHQTYPTIYHLRQALA 143

WP ^"002312694 74 RRRQRILELQKIFAPEILKIDEHFFARLNE- SFLV- -PDEKK- Q SRHPVFATIK- ^■QEKSYHQTYPTIYHLRQALA 143

WP ^"002314015 74 RRRQRILELQKIFAPEILKIDEHFFARLNE- SFLV- -LDEKK- Q SRHPVFATIK- ^■QEKSYHQTYPTIYHLRQALA 143

WP ^"002320716 74 RRRQRILELQKIFAPEILKIDEHFFARLNE- SFLV- -LDEKK- Q SRHPVFATIK- ^■QEKSYHQTYPTIYHLRQALA 143

WP ^"002330729 74 RRRQRILELQKIFAPEILKIDEHFFARLNE- SFLV- -LDEKK- Q SRHPVFATIK- ^■QEKSYHQTYPTIYHLRQALA 143

WP ^"002335161 74 RRRQRILELQKIFAPEILKIDEHFFARLNE- SFLV- -LDEKK- Q SRHPVFATIK- ^■QEKSYHQTYPTIYHLRQALA 143

WP ^"002345439 74 RRRQRILELQKIFAPEILKIDEHFFARLNE- SFLV- -LDEKK- Q SRHPVFATIK- ^■QEKSYHQTYPTIYHLRQALA 143

WP ^"034867970 74 RRKYRLSKLQDLFAEELCKQDDCFFVRLEE- SFLV- -PEEKQ- ^■Y KPASIFPTLE- ^■EEKEYYQKYPTIYHLRQKLV 143

WP ^"047937432 74 RRRQRILELQKIFAPEILKIDEHFFARLNE- SFLV- -LDEKK- Q SRHPVFATIK- ^■QEKSYHQTYPTIYHLRQALA 143

WP ^"010720994 74 RRKYRLSKLQDLFAEELCKQDDCFFVRLEE- SFLV- -PEEKQ- ^■Y KPASIFPTLE- ^■EEKEYYQKYPTIYHLRQKLV 143

WP ^"010737004 74 RRKYRLSKLQDLFAEELCKQDDCFFVRLEE- SFLV- -PEEKQ- ^■Y KPASIFPTLE- ^■EEKEYYQKYPTIYHLRQKLV 143

WP ^"034700478 74 RRKYRLSKLQDLFAEELCKQDDCFFVRLEE- SFLV- -PEEKQ- ^■Y KPASIFPTLE- ^■EEKEYYQKYPTIYHLRQKLV 143

WP ^"007209003 74 RRKNRICYLQEIFQPEMNHLDNNFFYRLNE- SFLVa —DDAK- ^■Y DKHPIFGTLD- ^■EEIHFHEQFPTIYHLRKYLA 143

WP ^"023519017 74 RRRQRVLALQDIFAEEIHKKDPNFFARLEE- GDRV- -EADKR- ^■F AKFPVFATLS- ^■EEKNYHRQYPTIYHLRHDLA 143

WP ^"010770040 74 RRRNRICRLQDLFTEEMNQVDANFFHRLQE- SFLV- -PDEKE- F ERHAIFGKME- ^■EEVSYYREFPTIYHLRKHLA 143

WP ^"048604708 74 RRRQRISYLQTFFQEEMNRIDPNFFNRLDE- ^■SFLI- -EEDKL- ^■S ERHPIFGTIE- ^■EEVAYHKNYATIYHLRKELA 143

WP ^"010750235 74 RRKYRILELQKIFSEEILKKDSHFFARLDE- ^■SFLI- -PEDKQ- ^■Y ARFPIFPTLL- ^■EEKAYYQNYPTIYHLRQKLA 143

AII16583 113 RRKNRICYLQEIFSNEMAKVDDSFFHRLEE- SFLV- -EEDKK- ^■H ERHPIFGNIV- ^■DEVAYHEKYPTIYHLRKKLV 182

WP 029073316 66 KRRERIRLLRGIMEDMVLDVDPTFFIRLANvSFLD- -QEDKKd .K SNYNLFIDKDfNDKTYYDKYPTIYHLRKHLC 144

WP ^"031589969 66 KRRERIRLLREIMEDMVLDVDPTFFIRLANvSFLD- -QEDKKd .K SNYNLFIDKDfNDKTYYDKYPTIYHLRKHLC 144

KDA45870 75 RRKNRLRYLQEI FAPALAKVDPNFFYRLEE- SSLVa —EDKK- ^■Y DVYPIFGKRE- ^■EELLYHDTHKTIYHLRSELA 144

WP 039099354 62 RRKWRLGLLREIFEPYITPVDDTFFLRKKQ- SNLS- -PKDQR- K -QTSLFNDRT- ^■-DRAFYDDYPTIYHLRYKLM 132

AKP02966 65 RRKNRINWLNEIFSEELANTDPSFLIRLQN- ^■SWVSkkDPDRK- ^■R DKYNLFIDNPyTDKEYYREFPTIFHLRKELI 137

WP 010991369 74 RRRNRISYLQGIFAEEMSKTDANFFCRLSD- ^■SFYV- -DNEKR- ^■N SRHPFFATIE- ^■EEVEYHKNYPTIYHLREELV 143

WP ^"033838504 74 RRRNRISYLQGIFAEEMSKTDANFFCRLSD- SFYV- -DNEKR- ^■N SRHPFFATIE- ^■EEVEYHKNYPTIYHLREELV 143

EHN60060 77 RRRNRISYLQGIFAEEMSKTDANFFCRLSD- SFYV- -DNEKR- ^■N SRHPFFATIE- ^■EEVEYHKNYPTIYHLREELV 146

EFR89594

WP 038409211 74 RRRNRIAYLQEI FAAEMAEVDANFFYRLED- ^■SFYI- -ESEKR- SRHPFFATIE-EEVAYHEEYKTIYHLREKLV 143

EFR95520

WP 003723650 74 RRRNRI SYLQEI FAVEMANIDANFFCRLND- SFYV- -DSEKR- N SRHPFFATIE- ^■EEVAYHDNYRTIYHLREKLV 143

WP ^"003727705 74 RRRNRI SYLQEI FAVEMANIDANFFCRLND- SFYV- -DSEKR- N SRHPFFATIE- ^■EEVAYHKNYRTIYHLREELV 143

WP ^"003730785 74 RRRNRI SYLQEI FAVEMANIDANFFCRLND- SFYV- -DSEKR- N SRHPFFATIE- ^■EEVAYHKNYRTIYHLREELV 143

WP ^"003733029 74 RRRNRI SYLQEI FAIQMNEVDDNFFNRLKE- SFYA- -ESDKK- Y NRHPFFGTVE- ^■EEVAYYKDFPTIYHLRKELI 143

WP ^"003739838 74 RRRNRI SYLQEI FALEMANIDANFFCRLND- SFYV- -DSEKR- N SRHPFFATIE- ^■EEVAYHKNYRTIYHLREELV 143

WP_014601172 74 RRRNRISYLQEIFAVEMANIDANFFCRLND-SFYV—DSEKR N SRHPFFATIE-EEVAYHKNYRTIYHLREELV 143

WP_023548323 74 RRRNRISYLQEIFAVEMANIDANFFCRLND-SFYV—DSEKR N SRHPFFATIE-EEVAYHKNYRTIYHLREELV 143

WP_031665337 74 RRRNRISYLQEIFAVEMANIDANFFCRLND-SFYV—DSEKR N SRHPFFATIE-EEVAYHKNYRTIYHLREELV 143

WP_031669209 74 RRRNRISYLQEIFAIQMNEVDDNFFNRLKE-SFYA—ESDKK Y NRHPFFGTVE-EEVAYYKDFPTIYHLRKELI 143

WP_033920898 74 RRRNRISYLQEIFAVEMANIDANFFCRLND-SFYV—DSEKR N SRHPFFATIE-EEVAYHKNYRTIYHLREELV 143

AKI42028 77 RRRNRISYLQEIFAVEMANIDANFFCRLND-SFYV—DSEKR N SRHPFFATIE-EEVAYHKNYRTIYHLREELV 146

AKI50529 77 RRRNRISYLQEIFAVEMANIDANFFCRLND-SFYV—DSEKR N SRHPFFATIE-EEVAYHKNYRTIYHLREELV 146

EFR83390

WP_046323366 74 RRRNRISYLQEIFTAEMFEVDANFFYRLED-SFYI—ESEKR Q SRHPFFATIE-EEVAYHENYRTIYHLREKLV 143

AKE81011 90 RRKNRICYLQEIFSNEMAKVDDSFFHRLEE-SFLV—EEDKK H ERHPIFGNIV-DEVAYHEKYPTIYHLRKKLV 159

CU082355 65 KRRERIRLLRAILQDMVLEKDPTFFIRLEHtSFLD—EEDKAkylG DNYNLFIDEDfNDYTYYHKYPTIYHLRKALC 143

WP_033162887 66 KRRERIRLLRDLLGDMVMEVDPTFFIRLLNvSFLD—EEDKQknlG DNYNLFIEKDfNDKTYYDKYPTIYHLRKELC 144

AGZ01981 107 RRKNRICYLQEIFSNEMAKVDDSFFHRLEE-SFLV—EEDKK H ERHPIFGNIV-DEVAYHEKYPTIYHLRKKLV 176

AKA60242 74 RRKNRICYLQEIFSNEMAKVDDSFFHRLEE-SFLV—EEDKK H ERHPIFGNIV-DEVAYHEKYPTIYHLRKKLV 143

AKS40380 74 RRKNRICYLQEIFSNEMAKVDDSFFHRLEE-SFLV—EEDKK H ERHPIFGNIV-DEVAYHEKYPTIYHLRKKLV 143

4UN5 B 78 RRKNRICYLQEIFSNEMAKVDDSFFHRLEE-SFLV—EEDKK H ERHPIFGNIV-DEVAYHEKYPTIYHLRKKLV 147

WP 010922251 144 DSTDKADLRLIYLALAHMI KFRGHFLI EGD-^■LNPDNSDV|JKL- -FIQLVQTYNQL- -FEEN- INASGVDAK-—AI 211

WP ^"039695303 145 DSSEKADLRLVYLALAHMI KFRGHFLI EGE- LNAENTDVQKI- -FADFVGVYNRT- -FDDS- H LSEITVDVA- — SI 212

WP ^"045635197 144 DSKEKTDLRLIYLALAHMI KYRGHFLYEEA- FDIKNNDIQKI- -FNEFISIYDNT- -FEGS- S LSGQNAQVE- —AI 211

WP 009880683

WP ^"010922251 144 DSTDKADLRLIYLALAHMIKFRGHFLIEGD- ^■LNPDNSDVDKL- -FIQLVQTYNQL- -FEEN- - INASGVDAK- —AI 211

WP ^"011054416 144 DSTDKVDLRLIYLALAHMI KFRGHFLI EGD- LNPDNSDVDKL- -FIQLVQTYNQL- -FEEN- - INASRVDAK- —AI 211

WP ^"011284745 144 DSTDKADLRLIYLALAHMI KFRGHFLI EGD- LNPDNSDVDKL- -FIQLVQTYNQL- -FEEN- - INASGVDAK- —AI 211

WP ^"011285506 144 DSTDKADLRLIYLALAHMI KFRGHFLI EGD- LNPDNSDVDKL- -FIQLVQTYNQL- -FEEN- - INASGVDAK- —AI 211

WP ^"011527619 144 DSTDKADLRLIYLALAHMI KFRGHFLI EGD- LNPDNSDVDKL- -FIQLVQTYNQL- -FEEN- - INASGVDAK- —AI 211

WP ^"012560673 144 DSTDKADLRLIYLALAHMI KFRGHFLI EGD- LNPDNSDVDKL- -FIQLVQTYNQL- -FEEN- - INASRVDAK- —AI 211

WP ^"014407541 144 DSTDKADLRLIYLALAHMI KFRGHFLI EGD- LNPDNSDVDKL- -FIQLVQIYNQL- -FEEN- - INASRVDAK- —AI 211

WP ^"020905136 144 DSTDKADLRLIYLALAHMI KFRGHFLI EGD- LNPDNSDVDKL- -FIQLVQTYNQL- -FEEN- - INASGVDAK- —AI 211

WP ^"023080005 144 DSTDKVDLRLIYLALAHMI KFRGHFLI EGD- LNPDNSDVDKL- -FIQLVQTYNQL- -FEEN- - INASRVDAK- —AI 211

WP ^"023610282 144 DSTDKVDLRLIYLALAHMI KFRGHFLI EGD- LNPDNSDVDKL- -FIQLVQTYNQL- -FEEN- - INASRVDAK- —AI 211

WP ^"030125963 144 DSTDKADLRLIYLALAHMI KFRGHFLI EGD- LNPDNSDVDKL- -FIQLVQTYNQL- -FEEN- - INASGVDAK- —AI 211

WP ^"030126706 144 DSTDKVDLRLIYLALAHMI KFRGHFLI EGD- LNPDNSDVDKL- -FIQLVQTYNQL- -FEEN- - INASRVDAK- —AI 211

WP ^"031488318 144 DSTDKADLRLIYLALAHMI KFRGHFLI EGD- LNPDNSDVDKL- -FIQLVQTYNQL- -FEEN- - INASRVDAK- —AI 211

WP ^"032460140 144 DSTDKADLRLIYLALAHMI KFRGHFLI EGD- LNPDNSDVDKL- -FIQLVQTYNQL- -FEEN- - INASRVDAK- —AI 211

WP ^"032461047 144 DSTDKADLRLIYLALAHMI KFRGHFLI EGG- LNPDNSDVDKL- -FIQLVQTYNQL- -FEEN- - INASRVDAK- —AI 211

WP ^"032462016 144 DSTDKADLRLIYLALAHMI KFRGHFLI EGD- LNPDNSDVDKL- -FIQLVQTYNQL- -FEEN- - INANGVDAK- —AI 211

WP ^"032462936 144 DSTDKADLRLIYLALAHMI KFRGHFLI EGD- LNPDNSDVDKL- -FIQLVQTYNQL- -FEEN- - INASRVDAK- —AI 211

WP ^"032464890 144 DSTDKADLRLIYLALAHMI KFRGHFLI EGD- LNPDNSDVDKL- -FIQLVQTYNQL- -FEEN- - INASGVDAK- —AI 211

WP ^"033888930 1 ^■— PDNSDVDKL- -FIQLVQTYNQL- -FEEN- - INASGVDAK- —AI 36

WP ^"038431314 144 DSTDKADLRLIYLALAHMI KFRGHFLI EGD- LNPDNSDVDKL- -FIQLVQTYNQL- -FEEN- - INASRVDAK- —AI 211

WP ^"038432938 144 DSTDKVDLRLIYLALAHMI KFRGHFLI EGD- LNPDNSDVDKL- -FIQLVQTYNQL- -FEEN- - INASRVDAK- —AI 211

WP ^"038434062 144 DSTDKADLRLIYLALAHMI KFRGHFLI EGD- LNPDNSDVDKL- -FIQLVQTYNQL- -FEEN- - INASRVDAK- —AI 211

BAQ51233 55 DSTDKADLRLIYLALAHMI KFRGHFLI EGD- LNPDNSDVDKL- -FIQLVQTYNQL- -FEEN- INASGVDAK- —AI 122

KGE60162

KGE60856

WP 002989955 144 DSTDKADLRLIYLALAHMI KFRGHFLI EGD- LNPDNSDVDKL- -FIQLVQTYNQL- -FEEN- - INASGVDAK- —AI 211

WP ^"003030002 144 DISQKADLRLVYLALAHMIKFRGHFLIEGQ- ^■LKAENTNVQAL- -FKDFVEVYDKT- -VEES- H LSEMTVDAL—SI 211

WP ^"003065552 147 DSSEKADLRLVYLALAHMIKFRGHFLIEGE- LNAENTDVQKI- -FADFVGVYDRT- -FDDS- H LSEITVDAA- —SI 214

WP ^"001040076 144 DKKEKADLRLVYLALAHIIKFRGHFLIEDDrFDVRNTDIQKQ- -YQAFLEIFDTT- -FENN- D LLSQDVDVE- —AI 212

WP ^"001040078 144 DKQEKADLRLIYLALAHIIKFRGHFLIEDDrFDVRNTDIQKQ- -YQAFLEIFDTT- -FENN- H LLSQNVDVE- —AI 212

WP ^"001040080 144 DKKEKADLRLIYIALAHIIKFRGHFLIEDDsFDVRNTDISKQ- -YQDFLEIFNIT- -FENN- D LLSQNVDVE- —AI 212

WP ^"001040081 144 DKKEKADLRLIYIALAHIIKFRGHFLIEDDsFDVRNTDISKQ- -YQDFLEIFNTI- -FENN- D LLSQNVDVE- —AI 212

WP ^"001040083 144 DKKEKADLRLIYIALAHIIKFRGHFLIEDDsFDVRNTDISKQ- -YQDFLEIFNTT- -FENN- D LLSQNVDVE- —AI 212

WP ^"001040085 144 DKKEKADLRLIYIALAHIIKFRGHFLIEDDsFDVRNTDISKQ- -YQDFLEIFNTT- -FENN- D LLSQNVDVE- —AI 212

WP 001040087 144 DKKEKADLRLIYIALAHI IKFRGHFLIEDDs FDVRNTDI SKQ--YQDFLEIFNTT--FENN-^•D LLSQNVDVE-—AI 212

WP ^"001040088 144 DKKEKADLRLIYIALAHI IKFRGHFLIEDDs FDVRNTDI SKQ- -YQDFLEIFNTT- -FENN- ^•D LLSQNVDVE- —AI 212

WP ^"001040089 144 DKKEKADLRLIYIALAHI IKFRGHFLIEDDs FDVRNTDI SKQ- -YQDFLEIFNTT- -FENN- ^■D LLSQNVDVE- —AI 212

WP ^"001040090 144 DKKEKADLRLIYIALAHI IKFRGHFLIEDDs FDVRNTDI SKQ- -YQDFLEIFNTT- -FENN- ^■D LLSQNVDVE- —AI 212

WP ^"001040091 144 DKKEKADLRLIYIALAHI IKFRGHFLIEDDs FDVRNTDI SKQ- -YQDFLEIFNTT- -FENN- ^■D LLSQNVDVE- —AI 212

WP ^"001040092 144 DKKEKADLRLVYLALAHI IKFRGHFLIEDDrFDVRNTDIQKQ- -YQAFLEIFDTS- -FENN- ^■H LLSQNVDVE- —AI 212

WP ^"001040094 144 DKKEKADLRLIYLALAHI IKFRGHFLIEDDrFDVRNTDIQKQ- -YQAFLEI FDTT- -FENN- ^■D LLSQNVDVE- —AI 212

WP ^"001040095 144 DKKEKADLRLIYLALAHI IKFRGHFLIEDDrFDVRNTDIQKQ- -YQAFLEI FDTT- -FENN- ^■D LLSQNVDVE- —AI 212

WP ^"001040096 144 DKKEKADLRLIYLALAHI IKFRGHFLIEDDrFDVRNTDIQKQ- -YQAFLEI FDTT- -FENN- ^■D LLSQNVDVE- —AI 212

WP ^"001040097 144 DKKEKADLRLIYLALAHI IKFRGHFLIEDDrFDVRNTDIQKQ- -YQAFLEI FDTT- -FENN- ^■D LLSQNVDVE- —AI 212

WP ^"001040098 144 DKKEKADLRLIYLALAHI IKFRGHFLIEDDrFDVRNTDIQKQ- -YQAFLEI FDTT- -FENN- ^■D LLSQNVDVE- —AI 212

WP ^"001040099 144 DKKEKADLRLIYLALAHI IKFRGHFLIEDDrFDVRNTDIQKQ- -YQAFLEI FDTT- -FENN- ^■D LLSQNVDVE- —AI 212

WP 001040100 144 DKKEKADLRLIYLALAHIIKFRGHFLIEDDrFDVRNTDIQKQ- -YQAFLEIFDTT- -FENN- ^■D LLSQNVDVE- —AI 212

WP ^"001040104 144 DKKEKADLRLIYIALAHI IKFRGHFLIEDDs FDVRNTDI SKQ- -YQDFLEIFNTT- -FENN- ^•D LLSQNVDVE- —AI 212

WP ^"001040105 144 DKKEKADLRLIYIALAHI IKFRGHFLIEDDs FDVRNTDI SKQ- -YQDFLEIFNTT- -FENN- ^•D LLSQNVDVE- —AI 212

WP ^"001040106 144 DKKEKANLRLVYLALAHI IKFRGHFLIEDDs FDVRNTDIQRQ- -YQAFLEI FDTT- -FENN- ^•H LLSQNIDVE- —GI 212

WP ^"001040107 144 DKKEKADLRLVYLALAHI IKFRGHFLIEDDs FDVRNTDIQRQ- -YQAFLEI FDTT- -FENN- ^•H LLSQNIDVE- —GI 212

WP ^"001040108 144 DKKEKADLRLVYLALAHI IKFRGHFLIEDDs FDVRNTDIQRQ- -YQAFLEI FDTT- -FENN- ^■H LLSQNIDVE- —GI 212

WP ^"001040109 144 DKKEKANLRLVYLALAHI IKFRGHFLIEDDs FDVRNTDIQRQ- -YQAFLEI FDTT- -FENN- ^■H LLSQNIDVE- —GI 212

WP ^"001040110 144 DKKEKANLRLVYLALAHI IKFRGHFLIEDDs FDVRNTDIQRQ- -YQAFLEI FDTT- -FENN- ^■H LLSQNIDVE- —GI 212

WP ^"015058523 144 DKKEKADLRLVYLALAHI IKFRGHFLIEDDrFDVRNTDIQKQ- -YQAFLEIFDTS- -FENN- ^■H LLSQNVDVE- —AI 212

WP ^"017643650 144 DKKEKADLRLIYLALAHI IKFRGHFLIEDDrFDVRNTDIQKQ- -YQAFLEI FDTT- -FENN- ^■D LLSQNVDVE- —AI 212

WP ^"017647151 144 DKKEKADLRLFYLALAHI IKFRGHFLIEDDs FDVRNTDIQRQ- -YQAFLEI FDTT- -FENN- ^■H LLSQNIDIE- —GI 212

WP ^"017648376 144 DKKEKADLRLFYLALAHI IKFRGHFLIEDDs FDVRNTDIQRQ- -YQAFLEI FDTT- -FENN- ^■H LLSQNIDVE- —GI 212

WP ^"017649527 144 DKKEKADLRLIYIALAHI IKFRGHFLIEDDs FDVRNTDI SKQ- -YQDFLEIFNTT- -FENN- ^■D LLSQNVDVE- —AI 212

WP ^"017771611 144 DKKEKADLRLVYLALAHI IKFRGHFLIEDDs FDVRNTDIQRQ- -YQAFLEI FDTT- -FENN- ^■H LLSQNIDVE- —GI 212

WP ^"017771984 144 DKKEKADLRLIYIALAHI IKFRGHFLIEDDs FDVRNTDI SKQ- -YQDFLEIFNTT- -FENN- ^■D LLSQNVDVE- —AI 212

CFQ25032 144 DKKEKADLRLIYIALAHI IKFRGHFLIEDDs FDVRNTDI SKQ- -YQDFLEIFNTT- -FENN- -D LLSQNVDVE- —AI 212

CFV16040 144 DKKEKADLRLIYIALAHI IKFRGHFLIEDDs FDVRNTDI SKQ- -YQDFLEIFNTT- -FENN- -D LLSQNVDVE- —AI 212

KLJ37842 144 DKKEKADLRLIYIALAHI IKFRGHFLIEDDs FDVRNTDI SKQ- -YQDFLEIFNTT- -FENN- -D LLSQNVDVE- —AI 212

KLJ72361 144 DKKEKADLRLIYIALAHI IKFRGHFLIEDDs FDVRNTDI SKQ- -YQDFLEIFNTT- -FENN- -D LLSQNVDVE- —AI 212

KLL20707 144 DKKEKADLRLIYIALAHI IKFRGHFLIEDDs FDVRNTDI SKQ- -YQDFLEIFNTT- -FENN- ^■D LLSQNVDVE- —AI 212

KLL42645 144 DKKEKANLRLVYLALAHI IKFRGHFLIEDDs FDVRNTDIQRQ- -YQAFLEI FDTT- -FENN- ^■H LLSQNIDVE- —GI 212

WP 047207273 144 DKKEKADLRLIYIALAHI IKFRGHFLIEDDs FDVRNTDI SKQ- -YQDFLEIFNTT- -FENN- ^■D LLSQNVDVE- —AI 212

WP ^"047209694 144 DKKEKADLRLIYLALAHI IKFRGHFLIEDDs FDVRNTDIQKQ- -YQAFLEI FDTT- -FENN- ^■D LLSQNVDVE- —AI 212

WP ^"050198062 144 DKKEKADLRLIYIALAHI IKFRGHFLIEDDs FDVRNTDI SKQ- -YQDFLEIFNTT- -FENN- ^■D LLSQNVDVE- —AI 212

WP ^"050201642 144 DKKEKADLRLIYIALAHI IKFRGHFLIEDDs FDVRNTDI SKQ- -YQDFLEIFNTT- -FENN- ^■D LLSQNVDVE- —AI 212

WP ^"050204027 144 DKKEKANLRLVYLALAHI IKFRGHFLIEDDs FDVRNTDIQRQ- -YQAFLEI FDTT- -FENN- ^■H LLSQNIDVE- —GI 212

WP ^"050881965 144 DKKEKADLRLIYIALAHI IKFRGHFLIEDDs FDVRNTDI SKQ- -YQDFLEIFNTT- -FENN- ^■D LLSQNVDVE- —AI 212

WP 050886065 144 DKKEKADLRLIYIALAHIIKFRGHFLIEDDsFDVRNTDISKQ -YQDFLEIFNTT--FENN-^■D LLSQNVDVE---AI 212

AHN30376 144 DKKEKADLRLVYLALAHIIKFRGHFLIEDDrFDVRNTDIQKQ -YQAFLEIFDTS- -FENN- ^■H LLSQNVDVE- - -AI 212

EA078426 144 DKKEKADLRLIYIALAHIIKFRGHFLIEDDsFDVRNTDISKQ -YQDFLEIFNTT- -FENN- ^■D LLSQNVDVE- - -AI 212

CCW42055 144 DKKEKADLRLVYLALAHIIKFRGHFLIEDDrFDVRNTDIQKQ -YQAFLEIFDTT- -FENN- ^■H LLSQNVDVE- - -AI 212

WP 0030415 02 144 DISQKADLRLVYLALAHMIKFRGHFLIEGQ- ^■LKAENTNVQAL -FKDFVEVYDKT- -VEES- ^■H LSEITVDAL- - -SI 211

WP ^"0375937 52 145 NSKEKADLRLVYLALAHMIKFRGHFLYEGD- ^■LKAENTDVQAL -FKDFVEEYDKT- -IEES- ^■H LSEITVDAL- - -SI 212

WP ^"0495166 84 145 DISQKADLRLVYLALAHMIKFRGHFLIEGQ- ^■LKAENTNVQAL -FKDFVEVYDKT- -VEES- ^■H LSEMTVDAL- - -SI 212

GAD46167 144 NSKEKADLRLVYLALAHMIKFRGHFLYEGD- ^■LKAENTDVQAL -FKDFVEEYDKT- -IEES- ^■H LSEITVDAL- - -SI 211

WP 0183634 70 145 DSTEKADLRLVYLALAHMIKFRGHFLIEGE- ^■LNAENTDVQKL -FTDFVGVYDRT- -FDDS- ^■H LSEITVDAA- - -SI 212

WP ^"0030438 19 144 DSPEKADLRLIYLALAHIIKFRGHFLIEGK- ^■LNAENSDVAKL -FYQLIQTYNQL- -FEES- - LDEIEVDAK- - -GI 211

WP ^"0062696 58 144 DTSKKADLRLVYLALAHMIKFRGHFLYEGD- ^■LKAENTDVQAL -FKDFVEEYDKT- -IEES- ^■H LSEITVDAL- - -SI 211

WP ^"0488008 89 144 DSTGKVDLRLVYLALAHMIKFRGHFLIEGQ- ^■LKAENTDVQTL -FNDFVEVYDKT- -IEES- ^■H LAEITVDAL- - -SI 211

WP ^"0127671 06 144 DSTDKADLRLIYLALAHMIKFRGHFLIEGD- ^■LNPDNSDMDKL -FIQLVQTYNQL- -FEEN- - INASRVDAK- - -AI 211

WP ^"0146123 33 144 DSTDKADLRLIYLALAHMIKFRGHFLIEGD- ^■LNPDNSDVDKL -FIQLVQTYNQL- -FEEK- - INASGVDAK- - -AI 211

WP ^"0150170 95 144 DSTDKADLRLIYLALAHMIKFRGHFLIEGD- ^■LNPDNSDMDKL -FIQLVQTYNQL- -FEEN- - INASRVDAK- - -AI 211

WP ^"0150576 49 144 DSTDKADLRLIYLALAHMIKFRGHFLIEGD- ^■LNPDNSDMDKL -FIQLVQTYNQL- -FEEN- - INASRVDAK- - -AI 211

WP ^"0483272 15 144 DSTDKADLRLIYLALAHMIKFRGHFLIEGD- ^■LNPDNSDMDKL -FIQLVQTYNQL- -FEEN- - INASRVDAK- - -AI 211

WP ^"0495193 24 144 DSTDKADLRLIYLALAHMIKFRGHFLIEGD- ^■LNPDNSDVDKL -FIQLVQTYNQL- -FEEN- - INASRVDAK- - -AI 211

WP ^"0125159 31 144 DNPQKADLRLIYLAVAHIIKFRGHFLIEGT- ^■LSSKNNNLQKS -FDHLVDTYNLL- -FEEQ- - LLTEGINAK- - -EL 211

WP ^"0213209 64 144 DNPQKADLRLIYLAVAHIIKFRGHFLIEGT- ^■LSSKNNNLQKS -FDHLVDTYNLL- -FEEQ- - LLTEGINAK- - -EL 211

WP ^"0375817 60 144 DNPQKADLRLIYLAVAHIIKFRGHFLIEGT- ^■LSSKNNNLQKS -FDHLVDTYNLL- -FEEQ- - LLTEGINAK- - -EL 211

WP ^"0042324 81 144 DSPEKVDLRLVYLALAHMIKFRGHFLIEGQ- ^■LNAENTDVQKI -FADFVGVYDRT- -FDDS- ^■H LSEITVDAA- - -SI 211

WP ^"0098545 40 145 DSSEKADLRLVYLALAHMIKYRGHFLIEGK- ^■LNAENTDVQKL -FTDFVGVYDRT- -FDDS- ^■H LSEITVDVA- - -ST 212

WP ^"0129621 74 145 DSHEKADLRLIYLALAHMIKFRGHFLIEGE- ^■LNAENTDVQKL -FEAFVEVYDRT- -FDDS- ^■N LSEITVDAS- - -SI 212

WP ^"0396953 03 145 DSSEKADLRLVYLALAHMIKFRGHFLIEGE- ^■LNAENTDVQKI -FADFVGVYNRT- -FDDS- ^■H LSEITVDVA- - -SI 212

WP ^"0143349 83 144 DSQEKADLRLVYLALAHMIKYRGHFLIEGE- ^■LNAENTDVQKL -FNVFVETYDKI- -VDES- ^■H LSEIEVDAS- - -SI 211

WP ^"0030992 69 144 DSDQKADLRLIYLALAHIIKFRGHFLIEGN- ^■LDSENTDVHVL -FLNLVNIYNNL- -FEED- - VETASIDAE- - -KI 211

AHY15608 144 DSDQKADLRLIYLALAHIIKFRGHFLIEGN- ^■LDSENTDVHVL -FLNLVNIYNNL- -FEED- VETASIDAE- - -KI 211

AHY17476 144 DSDQKADLRLIYLALAHIIKFRGHFLIEGN- ^■LDSENTDVHVL -FLNLVNIYNNL- -FEED- - VETASIDAE- - -KI 211

ESR09100

AGM98575 144 DSDQKADLRLIYLALAHIIKFRGHFLIEGN- ^■LDSENTDVHVL -FLNLVNIYNNL- -FEED- - VETASIDAE- - -KI 211

ALF27331 144 DNPEKTDLRLVYLALAHIIKFRGHFLIEGK- ^■FDTRNNDVQRL -FQEFLAVYDNT- -FENS- ^■S LQEQNVQVE- - -EI 211

WP 0183724 92 144 DTPDKMDIRLIYLALAHIIKYRGHFLIEGD- ^■LDIENIGIQDS -FKSFIEEYNTQ- -FGTK- - -LDSTTKVE- - -AI 209

WP ^"0456180 28 145 DSKEKADFRLIYLALAHIIKYRGHFLYEES- ^■FDIKNNDIQKI -FNEFISIYDNT- -FEGS- ^■s LNGQNAQVE- - -AI 212

WP ^"0456351 97 144 DSKEKTDLRLIYLALAHMIKYRGHFLYEEA- ^■FDIKNNDIQKI -FNEFISIYDNT- -FEGS- ^■s LSGQNAQVE- - -AI 211

WP ^"0022635 49 144 DNPEKVDLRLVYLALAHIIKFRGHFLIEGK- ^■FDTRNNDVQRL -FQEFLAVYDNT- -FENS- ^■s LQEQNVQVE- - -EI 211

WP ^"0022638 87 144 DNPEKVDLRLVYLALAHIIKFRGHFLIEGK- ^■FDTRNNDVQRL -FQEFLAVYDNT- -FENS- ^■s LQEQNVQVE- - -EI 211

WP ^"0022649 20 144 DSTEKADLRLVYLALAHMIKFRGHFLIEGE- ^■LNAENTDVQKL -FADFVGVYDRT- -FDDS- ^■H LSEITVDAS- - -SI 211

WP ^"0022690 43 144 DNPEKTDLRLVYLALAHIIKFRGHFLIEGK- ^■FDTRNNDVQRL -FQEFLAVYDNT- -FENS- ^■S LQEQNVQVE- - -EI 211

WP 002269448 144 DNPEKVDLRLVYLALAHIIKFRGHFLIEGK- FDTRNNDVQRL--FQEFLAVYDNT--FENS-^■S LQEQNVQVE-—EI 211

WP ^"0022 71977 144 DNPEKVDLRLVYLALAHIIKFRGHFLIEGK- FDTRNNDVQRL- -FQEFLAVYDNT- -FENS- ^■S LQEQNVQVE- —EI 211

WP ^"0022 72766 144 DNPEKVDLRLVYLALAHIIKFRGHFLIEGK- FDTRNNDVQRL- -FQEFLAVYDNT- -FENS- ^■S LQEQNVQVE- —EI 211

WP ^"0022 73241 144 DNPEKVDLRLVYLALAHIIKFRGHFLIEGK- FDTRNNDVQRL- -FQEFLAVYDNT- -FENS- ^■S LQEQNVQVE- —EI 211

WP ^"0022 75430 144 DNPEKVDLRLVYLALAHIIKFRGHFLIEGK- FDTRNNDVQRL- -FQEFLAVYDNT- -FENS- ^■S LQEQNVQVE- —EI 211

WP ^"0022 76448 144 DNPEKVDLRLVYLALAHIIKFRGHFLIEGK- FDTRNNDVQRL- -FQEFLAVYDNT- -FENS- ^■S LQEQNVQVE- —EI 211

WP ^"0022 77050 144 DSTEKADLRLVYLALAHMIKFRGHFLIEGE- LNAENTDVQKL- -FADFVGVYDRT- -FDDS- ^■H LSEITVDAS- — SI 211

WP ^"0022 77364 144 DNPEKVDLRLVYLALAHIIKFRGHFLIEGK- FDTRNNDVQRL- -FQEFLAVYDNT- -FENS- ^■S LQEQNVQVE- —EI 211

WP ^"0022 79025 144 DNPEKVDLRLVYLALAHIIKFRGHFLIEGK- FDTRNNDVQRL- -FQEFLAVYDNT- -FENS- ^■S LQEQNVQVE- —EI 211

WP ^"0022 79859 144 DSTEKADLRLVYLALAHMIKFRGHFLIEGE- LNAENTDVQKL- -FADFVGVYDRT- -FDDS- ^■H LSEITVDAS- — SI 211

WP ^"0022 80230 144 DNPEKVDLRLVYLALAHIIKFRGHFLIEGK- FDTRNNDVQRL- -FQEFLAVYDNT- -FENS- ^■S LQEQNVQVE- —EI 211

WP ^"0022 81696 144 DNPEKVDLRLVYLALAHIIKFRGHFLIEGK- FDTRNNDVQRL- -FQEFLAVYDNT- -FENS- ^■S LQEQNVQVE- —EI 211

WP ^"0022 82247 144 DSTEKADLRLVYLALAHMIKFRGHFLIEGE- LNAENTDVQKL- -FADFVGVYDRT- -FDDS- ^■H LSEITVDAS- — SI 211

WP ^"0022 82906 144 DNPEKVDLRLVYLALAHIIKFRGHFLIEGK- FDTRNNDVQRL- -FQEFLAVYDNT- -FENS- ^■S LQEQNVQVE- —EI 211

WP ^"0022 83846 144 DNPEKTDLRLVYLALAHIIKFRGHFLIEGK- FDTRNNDVQRL- -FQEFLAVYDNT- -FENS- ^■S LQEQNVQVE- —EI 211

WP ^"0022 87255 144 DNPEKVDLRLVYLALAHIIKFRGHFLIEGK- FDTRNNDVQRL- -FQEFLAVYDNT- -FENS- ^■S LQEQNVQVE- —EI 211

WP ^"0022 88990 144 DNPEKTDLRLVYLALAHIIKFRGHFLIEGK- FDTRNNDVQRL- -FQEFLAVYDNT- -FENS- ^■S LQEQNVQVE- —EI 211

WP ^"0022 89641 144 DNPEKTDLRLVYLALAHIIKFRGHFLIEGK- FDTRNNDVQRL- -FQEFLAVYDNT- -FENS- ^■s LQEQNVQVE- —EI 211

WP ^"0022 90427 144 DNPEKTDLRLVYLALAHIIKFRGHFLIEGK- FDTRNNDVQRL- -FQEFLAVYDNT- -FENS- ^■s LQEQNVQVE- —EI 211

WP ^"0022 95753 144 DNPEKVDLRLVYLALAHIIKFRGHFLIEGK- FDTRNNDVQRL- -FQEFLAVYDNT- -FENS- ^■s LQEQNVQVE- —EI 211

WP ^"0022 96423 144 DNPEKTDLRLVYLALAHIIKFGGHFLIEGK- FDTRNNDVQRL- -FQEFLAVYDNT- -FENS- ^■s LQEQNVQVE- —EI 211

WP ^"0023 04487 144 NSTEKADLRLVYLSLAHMIKFRGHFLIEGQ- LKAENTNVQAL- -FKDFVEVYDKT- -VEES- ^■H LSEMTVDAL- — SI 211

WP ^"0023 05844 144 DNPEKVDLRLVYLALAHIIKFRGHFLIEGK- FDTRNNDVQRL- -FQEFLAVYDNT- -FENS- ^■S LQEQNVQVE- —EI 211

WP ^"0023 07203 144 DNPEKVDLRLVYLALAHIIKFRGHFLIEGK- FDTRNNDVQKL- -FQEFLAVYDNT- -FENS- ^■S LQEQNVQVE- —EI 211

WP ^"0023 10390 144 DNPEKTDLRLVYLALAHIIKFRGHFLIEGK- FDTRNNDVQRL- -FQEFLAVYDNT- -FENS- ^■s LQEQNVQVE- —EI 211

WP ^"0023 52408 144 DNPEKTDLRLVYLALAHIIKFRGHFLIEGK- FDTRNNDVQRL- -FQEFLAVYDNT- -FENS- ^■s LQEQNVQVE- —EI 211

WP ^"0129 97688 144 DNPEKVDLRLVYLALAHIIKFRGHFLIEGK- FDTRNNDVQRL- -FQEFLAVYDNT- -FENS- ^■s LQEQNVQVE- —EI 211

WP ^"θ146 77909 144 DNPEKTDLRLVYLALAHIIKFRGHFLIEGK- FDTRNNDVQRL- -FQEFLAVYDNT- -FENS- ^■s LQEQNVQVE- —EI 211

WP ^"0193 12892 144 DNPEKVDLRLVYLALAHIIKFRGHFLIEGK- FDTRNNDVQRL- -FQEFLAVYDNT- -FENS- ^■s LQEQNVQVE- —EI 211

WP ^"0193 13659 144 DNPEKVDLRLVYLALAHIIKFRGHFLIEGK- FDTRNNDVQRL- -FQEFLAVYDNT- -FENS- ^■s LQEQNVQVE- —EI 211

WP ^"0193 14093 144 DNPEKVDLRLVYLALAHIIKFRGHFLIEGK- FDTRNNDVQKL- -FQEFLAVYDNT- -FENS- ^■s LQEQNVQVE- —EI 211

WP ^"0193 15370 144 DNPEKTDLRLVYLALAHIIKFRGHFLIEGK- FDTRNNDVQRL- -FQEFLAVYDNT- -FENS- ^■s LQEQNVQVE- —EI 211

WP ^"0198 03776 144 DNPEKVDLRLVYLALAHIIKFRGHFLIEGK- FDTRNNDVQRL- -FQEFLAVYDNT- -FENS- ^■s LQEQNVQVE- —EI 211

WP ^"0198 05234 144 DNPEKTDLRLVYLALAHIIKFRGHFLIEGK- FDTRNNDVQRL- -FQEFLAVYDNT- -FENS- ^■s LQEQNVQVE- —EI 211

WP ^"0247 83594 144 DNPEKVDLRLVYLALAHIIKFRGHFLIEGK- FDTRNNDVQRL- -FQEFLAVYDNT- -FENS- ^■s LQEQNVQVE- —EI 211

WP ^"0247 84288 144 DSTEKADLRLVYLALAHMIKFRGHFLIEGE- LNAENTDVQKL- -FADFVGVYDRT- -FDDS- ^■H LSEITVDAS- — SI 211

WP ^"0247 84666 144 DNPEKVDLRLVYLALAHIIKFRGHFLIEGK- FDTRNNDVQRL- -FQEFLAVYDNT- -FENS- ^■s LQEQNVQVE- —EI 211

WP ^"0247 84894 144 DNPEKTDLRLVYLALAHIIKFRGHFLIEGK- FDTRNNDVQRL- -FQEFLAVYDNT- -FENS- ^■s LQEQNVQVE- —EI 211

WP ^"0247 86433 144 DSTEKADLRLVYLALAHMIKFRGHFLIEGE- LNAENTDVQKL- -FADFVGVYDRT- -FDDS- ^■H LSEITVDAS- — SI 211

WP 049473442 144 DNPEKVDLRLVYLALAHIIKFRGHFLIEGK- FDTRNNDVQRL--FQEFLAVYDNT--FENS-^■S LQEQNVQVE-—EI 211

WP ^"049474547 144 DNPEKTDLRLVYLALAHIIKFRGHFLIEGK- FDTRNNDVQRL- -FQEFLAVYDNT- -FENS- ^■S LQEQNVQVE- —EI 211

EMC03581 137 DNPEKVDLRLVYLALAHIIKFRGHFLIEGK- FDTRNNDVQRL- -FQEFLAVYDNT- -FENS- ^■S LQEQNVQVE- —EI 204

WP 000428612 145 DSKEKTDLRLIYLALAHMIKYRGHFLYEDT- FDIKNNDIQKI- -FNEFISIYNNT- -FEGN- ^■S LSGQNVQVE- —AI 212

WP ^"000428613 145 DSKEKTDLRLIYLALAHMIKYRGHFLYEDT- FDIKNNDIQKI- -FSEFISIYDNT- -FEGS- ^■S LSGQNAQVE- —AI 212

WP ^"049523028 144 DSKEKVDLRLIYLALAHIIKYRGHFLYEDS- FDIKNNDIQKI- -FNEFTILYDNT- -FEES- ^■S LSKGNAQVE- —EI 211

WP ^"003107102 113 DSDEKADLRLIYLALAHIIKFRGHFLIEGD- LDSQNTDVNAL- -FLKLVDTYNLM- -FEDD- - IDTQTIDAT- —VI 180

WP ^"054279288 146 DNTEKADLRLIYLALAHIIKFRGHFLIEGA- LSANNTDVQQL- -VHALVDAYNIM- -FEED- LDIEAIDVK- —AI 213

WP ^"049531101 145 DSKEKADLRLIYLTLAHMIKYRGHFLYEES- FDIKNNDIQKI- -FNEFISIYDNT- -FEGS- ^■S LSGQNAQVE- —AI 212

WP ^"049538452 145 DSKEKADLRLIYLALAHMIKYRGHFLYEEA- FDIKNNDIQKI- -FNEFINIYDNT- -FEGS- ^■s LSGQNEQVE- —AI 212

WP ^"049549711 145 DSKEKADLRLIYLVLAHMIKYRGHFLYEEA- FDIKNNDIQKI- -FNEFISIYDNT- -FEGS- ^■s LSGQNAQVE- —TI 212

WP ^"007896501 146 DRDQKADLRLIYLALSHIIKFRGHFLIEGK- LNSENTDVQKL- -FIALVTVYNLL- -FEEE- - IAGETCDAK- —AL 213

EFR44625 98 DRDQKADLRLIYLALSHIIKFRGHFLIEGK- LNSENTDVQKL- -FIALVTVYNLL- -FEEE- IAGETCDAK- —AL 165

WP 002897477 144 DSKEKSDVRLIYLALAHMIKYRGHFLYEET- FDIKNNDIQKI- -FNEFINIYDNT- -FEGS- ^■s LSGQNAQVE- —AI 211

WP ^"002906454 144 DSKEKTDLRLIYLALAHMIKYRGHFLYEES- FDIKNNDIQKI- -FNEFISIYDNT- -FEGS- ^■s LSGQNAQVE- —AI 211

WP ^"009729476 145 DSKEKTDLRLIYLALAHMIKYRGHFLYEEA- FDIKNNDIQKI- -FNEFISIYNNT- -FEGN- ^■s LSGQNVQVE- —AI 212

CQR24647 144 DSSEKADLRLVYLALAHIIKYRGHFLIDEP- IDIRNMNSQNL- -FKEFLLAFDGI- -QVDC- ^■Y LASKHTDIS- —GI 211

WP 000066813 145 DSKEKTDLRLIYLALAHMIKYRGHFLYEES- FDIKNNDIQKI- -FSEFISIYDNT- -FEGK- ^■s LSGQNAQVE- —AI 212

WP ^"009754323 145 DSKEKADLRLIYLALAHITKYRGHFLYEEA- FDIKNNDIQKI- -FNEFINIYDNT- -FEGS- ^■s LSGQNAQVE- —AI 212

WP ^"044674937 144 DSSQKADIRLIYLALAHIIKYRGHFLFEGD- LKSENKDVQHL- -FNDFVEMFDKT- -VEGS- ^■Y LSENLPNVA- —DV 211

WP ^"044676715 144 DSSQKADIRLIYLALAHIIKYRGHFLFEGD- LKSENKDVQHL- -FNDFVEMFDKT- -VEGS- ^■Y LSENLPNVA- —DV 211

WP ^"044680361 144 DSSQKADIRLIYLALAHIIKYRGHFLFEGD- LKSENKDVQHL- -FNDFVEMFDKT- -VEGS- ^■Y LSENLPNVA- —DV 211

WP ^"044681799 144 DSSQKADIRLIYLALAHIIKYRGHFLFEGD- LKSENKDVQHL- -FNDFVEMFDKT- -VEGS- ^■Y LSENLPNVA- —DV 211

WP ^"049533112 144 DISQKADLRLVYLALAHMIKFRGHFLIEGQ- LKAENTNVQAL- -FKDFVEVYDKT- -VEES- ^■H LSEMTVDAL—SI 211

WP ^"029090905 101 SQHRQFDIREVYLAIHHLIKYRGHFIYEDQtFTTDGNQLQHH- -IKAIITMINST1 NR- II PETIDINvfeKI 171

WP ^"006506696 140 ESTEKADPRLIYLALHHIVKYRGNFLYEGQkFNMDASNIEDK- -LSDIFTQFTSFnnlPYEdD —KKNLEIL- —EI 210

AIT42264 144 DSTDKADLRLIYLALAHMIKFRGHFLIEGD- LNPDNSDVDKL- -FIQLVQTYNQL- -FEEN- INASGVDAK- —AI 211

WP 034440723 143 DSNQKADLRLIYLALAHMIKYRGHFLIEGD- LKMDGISISES- -FQEFIDSYNEVcaLEDE- ^■N NDELLTQIE- —NI 217

AKQ21048 144 DSTDKADLRLIYLALAHMIKFRGHFLIEGD- LNPDNSDVDKL- -FIQLVQTYNQL- -FEEN- - INASGVDAK- —AI 211

WP 004636532 144 DNPEKADLRLVYTALAHIVKYRGHFLIEGE- LNTENTSISET- -FEQFLDTYSDI- -FKEQ- - LVGDISKVE- —EI 210

WP ^"002364836 144 DSSEQADLRLIYLALAHIVKYRGHFLIEGK- LSTENISVKEQ- -FQQFMIIYNQT- - VNGeS PLPESVLIE- —EE 217

WP ^"016631044 95 DSSEQADLRLIYLALAHIVKYRGHFLIEGK- LSTENTSVKDQ- -FQQFMVIYNQT- -FVNGeS PLPESVLIE- —EE 168

EMS75795

WP 002373311 144 DSSEQADLRLIYLALAHIVKYRGHFLIEGK- LSTENTSVKEQ- -FQQFMVIYNQT- - VNGeS PLPESVLIE- —EE 217

WP ^"002378009 144 DSSEQADLRLIYLALAHIVKYRGHFLIEGK- LSTENISVKEQ- -FQQFMIIYNQT- -FVNGeS PLPESVLIE- —EE 217

WP ^"002407324 144 DSSEQADLRLIYLALAHIVKYRGHFLIEGK- LSTENISVKEQ- -FQQFMIIYNQT- -FVNGeS PLPESVLIE- —EE 217

WP ^"002413717 144 DSSEQADLRLIYLALAHIVKYRGHFLIEGK- LSTENISVKEQ- -FQQFMIIYNQT- -FVNGeS PLPESVLIE- —EE 217

WP ^"010775580 144 DSSEQADLRLIYLALAHIVKYRGHFLIEGK- LSTENISVKEQ- -FQQFMIIYNQT- -FVNGeS PLPESVLIE- —EE 217

WP ^"010818269 144 DSSEQADLRLIYLALAHIVKYRGHFLIEGK- LSTENISVKEQ- -FQQFMIIYNQT- -FVNGeS PLPESVLIE- —EE 217

WP 010824395 144 DSSEQADLRLIYLALAHIVKYRGHFLIEGK-^■LSTENTSVKDQ--FQQFMVIYNQT--F GeS PLPESVLIE-—EE 217

WP ^"016622645 144 DSSEQADLRLIYLALAHIVKYRGHFLIEGK- ^■LSTENISVKEK- -FQQFMIIYNQT- -F GeG PLPESVLIE- —EE 217

WP ^"033624816 144 DSSEQADLRLIYLALAHIVKYRGHFLIEGK- ^■LSTENISVKDQ- -FQQFMVIYNQT- -F GeS PLPESVLIE- —EE 217

WP ^"033625576 144 DSSEQADLRLIYLALAHIVKYRGHFLIEGK- ^■LSTENISVKEQ- -FQQFMIIYNQT- -F GeS PLPESVLIE- —EE 217

WP ^"033789179 144 DSSEQADLRLIYLALAHIVKYRGHFLIEGK- ^■LSTENISVKEQ- -FQQFMIIYNQT- -FWGeS PLPESVLIE- —EE 217

WP ^"002310644 144 DSSEKADIRLVYLAMAHLLKYRGHFLIEGE- ^■LNTENSSVTET- -FRQFLSTYNQQ- -FSEA-D KLDEAVDCS- —FV 216

WP ^"002312694 144 DSSEKADIRLVYLAMAHLLKYRGHFLIEGE- ^■LNTENSSVTET- -FRQFLSTYNQQ- -FSEA-G KLDEAVDCS- —FV 216

WP ^"002314015 144 DSSEKADIRLVYLAMAHLLKYRGHFLIEGE- ^■LNTENSSVTET- -FRQFLSTYNQQ- -FSEA-D KLDEAVDCS- —FV 216

WP ^"002320716 144 DSSEKADIRLVYLAMAHLLKYRGHFLIEGE- ^■LNTENSSVTET- -FRQFLSTYNQQ- -FSEA-D KLDEAVDCS- —FV 216

WP ^"002330729 144 DSSEKADIRLVYLAMAHLLKYRGHFLIEGE- ^■LNTENSSVTET- -FRQFLSTYNQQ- -FSEA-D KLDEAVDCS- —FV 216

WP ^"002335161 144 DSSEKADIRLVYLAMAHLLKYRGHFLIEGE- ^■LNTENSSVTET- -FRQFLSTYNQQ- -FSEA-D KLDEAVDCS- —FV 216

WP ^"002345439 144 DSSEKADIRLVYLAMAHLLKYRGHFLIEGE- ^■LNTENSSVTET- -FRQFLSTYNQQ- -FSEA-D KLDEAVDCS- —FV 216

WP ^"034867970 144 DSTEKEDLRLVYLALAHLLKYRGHFLFEGD- ^■LDTENTSIEES- -FRVFLEQYSKQ- -SDQP— -LIVHQPVL- —TI 209

WP ^"047937432 144 DSSEKADIRLVYLAMAHLLKYRGHFLIEGE- ^■LNTENSSVTET- -FRQFLSTYNQQ- -FSEA-D KLDEAVDCS- —FV 216

WP ^"010720994 144 DSTEKGDLRLVYLALAHLLKYRGHFLFEGD- ^■LDTENTSIEES- -FRVFLEQYGKQ- -SDQP— -LIVHQPVL- —TI 209

WP ^"010737004 144 DSTEKEDLRLVYLALAHLLKYRGHFLFEGD- ^■LDTENTSIEES- -FRVFLEQYSKQ- -SDQP— -LIVHQPVL- —TI 209

WP ^"034700478 144 DSTEKEDLRLVYLALAHLLKYRGHFLFEGD- ^■LDTENTSIEES- -FRVFLEQYGKQ- -SDQP— -LIVHQPVL- —TI 209

WP ^"007209003 144 DGDEKADLRLVYLAIAHIIKFRGNFLIEGE- ^■LNTENNSVIELs —KVFVQLYNQT1 -SELE— FIDESIDFS- —EV 214

WP ^"023519017 144 NSKEQADIRLVYLAIAHCLKYRGHFLFEGE- ^■LDTENTSVTEN- -YQQFLQAYQQF- -FPEP— -IGDLDDAV- —PI 209

WP ^"010770040 144 DTSEQADLRLVYLALAHIVKYRGHFLIEGE- ^■LNTENSSVSET- -FRTFIQVYNQI- -FRENe- PLAVPDNIE- —EL 212

WP ^"048604708 144 DAEEKADLRLVYLALAHIIKYRGHFLIEGR- ^■LSTENTSTEET- -FKTFLQKYNQT- -FN PVDETISIG- —SI 208

WP ^"010750235 144 DSTEKADIRLVYLALAHMIKYRGHFLFEGE- ^■LDTENTSVEET- -FKEFIDIYNEQ- -FEEG— -IIFYKDIP- —LI 209

AII16583 183 DSTDKADLRLIYLALAHMIKFRGHFLIEGD- ^■LNPDNSDVDKL- -FIQLVQTYNQL- -FEEN— INASGVDAK- —AI 250

WP 029073316 145 ESKEKEDPRLIYLALHHIVKYRGNFLYEGQkFSMDVSNIEDK- -MIDVLRQFNEInlFEYVeD —KKIDEVL- —NV 215

WP ^"031589969 145 ESKEKEDPRLIYLALHHIVKYRGNFLYEGQkFSMDVSNIEDK- -MIDVLRQFNEInlFEYVeD —KKIDEVL- —NV 215

KDA45870 145 NNDRPADLRLVYLALAHIIKYRGNFLLEGE- ^■IDLRTTDINKV- -FAEFSETLNEN- -SDEN1G KLDVA- —DI 209

WP 039099354 133 TEKRQFDIREIYLAMHHIVKYRGHFLNEAPvSSFKSSEINLVahFDRLNTIFADL- -FSESgF -TDKLAEVK- —AL 206

AKP02966 138 INKNKADIRLVYLALHNILKYRGNFTYEHQkFNISTLNSNLS- —KELIELNQQLikYDIS— -FPDNCDWNhisDI 208

WP 010991369 144 NSSEKADLRLVYLALAHIIKYRGNFLIEGA- ^■LDTQNTSVDGI- -YKQFIQTYNQV- -FASGiE KLEDNKDVA- —KI 217

WP ^"033838504 144 NSSEKADLRLVYLALAHIIKYRGNFLIEGA- ^■LDTQNTSVDGI- -YKQFIQTYNQV- -FASGiE KLEDNKDVA- —KI 217

EHN60060 147 NSSEKADLRLVYLALAHIIKYRGNFLIEGA- ^■LDTQNTSVDGI- -YKQFIQTYNQV- -FASGiE KLEDNKDVA- —KI 220

EFR89594

WP 038409211 144 NSSDKADLRLVYLALAHIIKYRGNFLIEGM- ^■LDTKNTSVDEV- -FKQFIQTYNQI- -FASDiE RLEENKEVA- —EI 217

EFR95520

WP 003723650 144 NSSEKADLRLVYLALAHIIKYRGNFLIEGA- ^■LDTKNTSVDEV- -YKQFIETYNQV- -FMSNiE KVEENIEVA- —NI 217

WP ^"003727705 144 NSSEKADLRLVYLALAHIIKYRGNFLIEGA- ^■LDTKNTSVDEV- -YKQFIQTYNQV- -FMSNiE KVEENTEVA- —SI 217

WP ^"003730785 144 NSSEKADLRLVYLALAHIIKYRGNFLIEGA- ^■LDTKNTSVDEV- -YKQFIQTYNQV- -FMSNiE KVEENTEVA- —SI 217

WP ^"003733029 144 DSQKKADLRLVYLALAHIIKYRGHFLIEGA- ^■LDTKNTSIDEM- -FKQFLQIYNQV- -FANDiE KTEKNQEVA- —QI 217

WP ^"003739838 144 NSSEKADLRLVYLALAHIIKYRGNFLIEGA- ^■LDTKNTSVDGV- -YKQFIQTYNQV- -FISNiE KMEENTTVA- —DI 217

WP 014601172 144 NSSEKADLRLVYLALAHI IKYRGNFLIEGA- LDTKNTSVDGV- -YEQFIQTYNQV- -FMSNiE KVEENIEVA-

WP 023548323 144 NSSEKADLRLVYLALAHI IKYRGNFLIEGA- LDTKNTSVDGV- -YEQFILTYNQV- -FMSNiE KVEENIEVA-

WP 031665337 144 NSSEKADLRLVYLALAHI IKYRGNFLIEGA- LDTKNTSVDGV- -YEQFIQTYNQV- -FMSNiE KVEENIEVA-

WP 031669209 144 DSQKKADLRLVYLALAHI IKYRGHFLIEGA- LDTKNTSIDEM- -FKQFLQIYNQV- -FANDiE KTEKNQEVA-

WP 033920898 144 NSSEKADLRLVYLALAHI IKYRGNFLIEGA- LDTKNTSVDGV- -YEQFIQTYNQV- -FMSNiE KVEENIEVA-

AKI42028 147 NSSEKADLRLVYLALAHI IKYRGNFLIEGA- LDTKNTSVDGV- -YEQFIQTYNQV- -FMSNiE KVEENIEVA-

AKI50529 147 NSSEKADLRLVYLALAHI IKYRGNFLIEGA- LDTKNTSVDGV- -YEQFIQTYNQV- -FMSNiE KVEENIEVA-

EFR83390

WP 046323366 144 NSSDKADLRLVYLALAHIIKYRGNFLIEGK-LDTKNTSVDEV- -FKQFIKTYNQV—FASDiE RIEENNEVA-

AKE81011 160 DSTDKADLRLIYLALAHMIKFRGHFLIEGD-LNPDNSDVDKL- -FIQLVQTYNQL—FEEN— INASGVDAK-

CU082355 144 ESTEKADPRLIYLALHHIVKYRGNFLYEGQkFNMDASNIEDK- -LSDVFTQFADFnnlPYEdD —KKNLEIL-

WP 033162887 145 ENKEKADPRLIYLALHHIVKYRGNFLYEGQsFTMDNSDIEER- -LNSAIEKFMSIneFDNRiV —SDINSMI-

AGZ 01981 177 DSTDKADLRLIYLALAHMIKFRGHFLIEGD-LNPDNSDVDKL- -FIQLVQTYNQL—FEEN— INASGVDAK-

AKA60242 144 DSTDKADLRLIYLALAHMIKFRGHFLIEGD-LNPDNSDVDKL- -FIQLVQTYNQL—FEEN— INASGVDAK-

AKS40380 144 DSTDKADLRLIYLALAHMIKFRGHFLIEGD-LNPDNSDVDKL- -FIQLVQTYNQL—FEEN— INASGVDAK-

4UN5 B 148 DSTDKADLRLIYLALAHMIKFRGHFLIEGD-LNPDNSDVDKL- -FIQLVQTYNQL—FEEN— INASGVDAK-

WP 010922251 212 LSAR-^■LSKSRRLENLIAQ-^■L- PG EKKNGLFGNLIALSLGLTPNFKSNF--DLAED-H5H--KLQ--LSKDTYDDDLDN 277

WP ^"039695303 213 LTEK- ^■ISKSRRLENLIKY- ^■Y- PT EKKNTLFGNLIALALGLQPNFKTNF- -KLSED- -A— -KLQ- -FSKDTYEEDLEE 278

WP ^"045635197 212 FTDK- ^■ISKSAKRERVLKL- ^■F- PD EKSTGLFSEFLKLIVGNQADFKKHF- -DLEDK- -A— -PLQ- -FSKDTYDEDLEN 277

WP ^"010922251 212 LSAR- ^■LSKSRRLENLIAQ- ^■L- PG EKKNGLFGNLIALSLGLTPNFKSNF- -DLAED- -A— -KLQ- -LSKDTYDDDLDN 277

WP ^"011054416 212 LSAR- ^■LSKSRRLENLIAQ- ^■L- PG EKKNGLFGNLIALSLGLTPNFKSNF- -DLAED- -A— -KLQ- -LSKDTYDDDLDN 277

WP ^"011284745 212 LSAR- ^■LSKSRRLENLIAQ- ^■L- PG EKKNGLFGNLIALSLGLTPNFKSNF- -DLAED- -A— -KLQ- -LSKDTYDDDLDN 277

WP ^"011285506 212 LSAR- ^■LSKSRRLENLIAQ- ^■L- PG EKKNGLFGNLIALSLGLTPNFKSNF- -DLAED- -A— -KLQ- -LSKDTYDDDLDN 277

WP ^"011527619 212 LSAR- ^■LSKSRRLENLIAQ- ^■L- PG EKKNGLFGNLIALSLGLTPNFKSNF- -DLAED- -A— -KLQ- -LSKDTYDDDLDN 277

WP ^"012560673 212 LSAR- ^■LSKSRRLENLIAQ- ^■L- PG EKRNGLFGNLIALSLGLTPNFKSNF- -DLAED- -A— -KLQ- -LSKDTYDDDLDN 277

WP ^"014407541 212 LSAR- ^■LSKSRRLENLIAQ- ^■L- PG EKRNGLFGNLIALSLGLTPNFKSNF- -DLAED- -A— -KLQ- -LSKDTYDDDLDN 277

WP ^"020905136 212 LSAR- ^■LSKSRRLENLIAQ- ^■L- PG EKKNGLFGNLIALSLGLTPNFKSNF- -DLAED- -A— -KLQ- -LSKDTYDDDLDN 277

WP ^"023080005 212 LSAR- ^■LSKSRRLENLIAQ- ^■L- PG EKKNGLFGNLIALSLGLTPNFKSNF- -DLAED- -A— -KLQ- -LSKDTYDDDLDN 277

WP ^"023610282 212 LSAR- ^■LSKSRRLENLIAQ- ^■L- PG EKKNGLFGNLIALSLGLTPNFKSNF- -DLAED- -A— -KLQ- -LSKDTYDDDLDN 277

WP ^"030125963 212 LSAR- ^■LSKSRRLENLIAQ- ^■L- PG EKKNGLFGNLIALSLGLTPNFKSNF- -DLAED- -A— -KLQ- -LSKDTYDDDLDN 277

WP ^"030126706 212 LSAR- ^■LSKSRRLENLIAQ- ^■L- PG EKKNGLFGNLIALSLGLTPNFKSNF- -DLAED- -A— -KLQ- -LSKDTYDDDLDN 277

WP ^"031488318 212 LSAR- ^■LSKSRRLENLIAQ- ^■L- PG EKRNGLFGNLIALSLGLTPNFKSNF- -DLAED- -A— -KLQ- -LSKDTYDDDLDN 277

WP ^"032460140 212 LSAR- ^■LSKSRRLENLIAQ- ^■L- PG EKRNGLFGNLIALSLGLTPNFKSNF- -DLAED- -A— -KLQ- -LSKDTYDDDLDN 277

WP ^"032461047 212 LSAR- ^■LSKSRRLENLIAQ- ^■L- PG EKRNGLFGNLIALSLGLTPNFKSNF- -DLAED- -A— -KLQ- -LSKDTYDDDLDN 277

WP ^"032462016 212 LSAR- ^■LSKSRRLENLIAQ- ^■L- PG EKKNGLFGNLIALSLGLTPNFKSNF- -DLAED- -A— -KLQ- -LSKDTYDDDLDN 277

WP ^"032462936 212 LSAR- ^■LSKSRRLENLIAQ- ^■L- PG EKKNGLFGNLIALLLGLTPNFKSNF- -DLAED- -A— -KLQ- -LSKDTYDDDLDN 277

WP ^"032464890 212 LSAR- ^■LSKSRRLENLIAQ- ^■L- PG EKKNGLFGNLIALSLGLTPNFKSNF- -DLAED- -A— -KLQ- -LSKDTYDDDLDN 277

WP ^"033888930 37 LSAR- ^■LSKSRRLENLIAQ- ^■L- PG EKKNGLFGNLIALSLGLTPNFKSNF- -DLAED- -A— -KLQ- -LSKDTYDDDLDN 102

WP ^"038431314 212 LSAR- ^■LSKSRRLENLIAQ- ^■L- PG EKKNGLFGNLIALSLGLTPNFKSNF- -DLAED- -A— -KLQ- -LSKDTYDDDLDN 277

WP ^"038432938 212 LSAR- ^■LSKSRRLENLIAQ- ^■L- PG EKKNGLFGNLIALSLGLTPNFKSNF- -DLAED- -T— -KLQ- -LSKDTYDDDLDN 277

WP ^"038434062 212 LSAR- ^■LSKSRRLENLIAQ- ^■L- PG EKRNGLFGNLIALSLGLTPNFKSNF- -DLAED- -A— -KLQ- -LSKDTYDDDLDN 277

BAQ51233 123 LSAR- ^■LSKSRRLENLIAQ- ^■L- PG EKKNGLFGNLIALSLGLTPNFKSNF- -DLAED- -A— -KLQ- -LSKDTYDDDLDN 188

KGE60162

KGE60856

WP 002989955 212 LSAR- ^■LSKSRRLENLIAQ- ^■L- PG EKKNGLFGNLIALSLGLTPNFKSNF- -DLAED- -A— -KLQ- -LSKDTYDDDLDN 277

WP ^"003030002 212 LTEK- ^■VSKSRRLENLIAH- ^■Y- PA EKKNTLFGNLIALSLGLQPNFKTNF- -QLSED- -A— -KLQ- -FSKDTYEEDLEG 277

WP ^"003065552 215 LTEK- ^■ISKSRRLENLIKY- ^■Y- PT EKKNTLFGNLIALALGLQPNFKMNF- -KLSED- -A— -KLQ- -FSKDSYEEDLGE 280

WP ^"001040076 213 LTDK- ^■ISKSAKKDRILAQ- ^■Y- PN QKSTGI FAEFLKLIVGNQADFKKHF- -NLEDK- -T— -PLQ- -FAKDSYDEDLEN 278

WP ^"001040078 213 LTDK- ^■ISKSAKKDRILAQ- ^■Y- PN QKSTGI FAEFLKLIVGNQADFKKHF- -NLEDK- -T— -PLQ- -FAKDSYDEDLEN 278

WP ^"001040080 213 LTDK- ^■ISKSAKKDRILAQ- ^■Y- PN QKSTGI FAEFLKLIVGNQADFKKYF- -NLEDK- -T— -PLQ- -FAKDSYDEDLEN 278

WP ^"001040081 213 LTDK- ^■ISKSAKKDRILAQ- ^■Y- PN QKSTGI FAEFLKLIVGNQADFKKYF- -NLEDK- -T— -PLQ- -FAKDSYDEDLEN 278

WP ^"001040083 213 LTDK- ^■ISKSAKKDRILAQ- ^■Y- PN QKSTGI FAEFLKLIVGNQADFKKYF- -NLEDK- -T— -PLQ- -FAKDSYDEDLEN 278

WP ^"001040085 213 LTDK- ^■ISKSAKKDRILAQ- ^■Y- PN QKSTGI FAEFLKLIVGNQADFKKYF- -NLEDK- -T— -PLQ- -FAKDSYDEDLEN 278

WP 001040087 213 LTDK- ISKSAKKDRILAQ-^■Y-^■PN QKSTGI FAEFLKLIVGNQADFKKYF--NLEDK--T-—PLQ--FAKDSYDEDLEN 278

WP 001040088 213 LTDK- ISKSAKKDRILAQ- ^■Y- ^■PN QKSTGI FAEFLKLIVGNQADFKKYF- -NLEDK- ^■T- —PLQ- -FAKDSYDEDLEN 278

WP 001040089 213 LTDK- ISKSAKKDRILAQ- ^■Y- ^■PN QKSTGI FAEFLKLIVGNQADFKKYF- -NLEDK- ^■T- —PLQ- -FAKDSYDEDLEN 278

WP 001040090 213 LTDK- ISKSAKKDRILAQ- ^■Y- ^■PN QKSTGI FAEFLKLIVGNQADFKKYF- -NLEDK- ^■T- —PLQ- -FAKDSYDEDLEN 278

WP 001040091 213 LTDK- ISKSAKKDRILAQ- ^■Y- ^■PN QKSTGI FAEFLKLIVGNQADFKKYF- -NLEDK- ^■T- —PLQ- -FAKDSYDEDLEN 278

WP 001040092 213 LTDK- ISKSAKKDRILAQ- ^■Y- PN QKSTGI FAEFLKLIVGNQADFKKHF- -NLEDK- ^■T- —PLQ- -FAKDSYDEDLEN 278

WP 001040094 213 LTDK- ISKSAKKDRILAR- ^■Y- PN QKSTGI FAEFLKLIVGNQADFKKHF- -NLEDK- ^■T- —PLQ- -FAKDSYDEDLEN 278

WP 001040095 213 LTDK- ISKSAKKDRILAR- ^■Y- PN QKSTGI FAEFLKLIVGNQADFKKHF- -NLEDK- ^■T- —PLQ- -FAKDSYDEDLEN 278

WP 001040096 213 LTDK- ISKSAKKDRILAR- ^■Y- PN QKSTGI FAEFLKLIVGNQADFKKHF- -NLEDK- ^■T- —PLQ- -FAKDSYDEDLEN 278

WP 001040097 213 LTDK- ISKSAKKDRILAR- ^■Y- PN QKSTGI FAEFLKLIVGNQADFKKHF- -NLEDK- ^■T- —PLQ- -FAKDSYDEDLEN 278

WP 001040098 213 LTDK- ISKSAKKDRILAR- ^■Y- PN QKSTGI FAEFLKLIVGNQADFKKHF- -NLEDK- -T- —PLQ- -FAKDSYDEDLEN 278

WP 001040099 213 LTDK- ISKSAKKDRILAR- ^■Y- PN QKSTGI FAEFLKLIVGNQADFKKHF- -NLEDK- ^■T- —PLQ- -FAKDSYDEDLEN 278

WP 001040100 213 LTDK- ISKSAKKDRILAR- ^■Y- PN QKSTGI FAEFLKLIVGNQADFKKHF- -NLEDK- ^■T- —PLQ- -FAKDSYDEDLEN 278

WP 001040104 213 LTDK- ISKSAKKDRILAQ- ^■Y- PN QKSTGI FAEFLKLIVGNQADFKKYF- -NLEDK- ^■T- —PLQ- -FAKDSYDEDLEN 278

WP 001040105 213 LTDK- ISKSAKKDRILAQ- ^■Y- PN QKSTGI FAEFLKLIVGNQADFKKYF- -NLEDK- ^■T- —PLQ- -FAKDSYDEDLEN 278

WP 001040106 213 LTDK- ISKSAKKDRILAQ- ^■Y- PN QKSTGI FAEFLKLIVGNQADFKKHF- -NLEDK- ^■T- —PLQ- -FAKDSYDEDLEN 278

WP 001040107 213 LTDK- ISKSAKKDRILAQ- ^■Y- PN QKSTGI FAEFLKLIVGNQADFKKHF- -NLEDK- ^■T- —PLQ- -FAKDSYDEDLEN 278

WP 001040108 213 LTDK- ISKSAKKDRILAQ- ^■Y- PN QKSTGI FAEFLKLIVGNQADFKKHF- -NLEDK- ^■T- —PLQ- -FAKDSYDEDLEN 278

WP 001040109 213 LTDK- ISKSAKKDRILAQ- ^■Y- PN QKSTGI FAEFLKLIVGNQADFKKHF- -NLEDK- ^■T- —PLQ- -FAKDSYDEDLEN 278

WP 001040110 213 LTDK- ISKSAKKDRILAQ- ^■Y- PN QKSTGI FAEFLKLIVGNQADFKKHF- -NLEDK- ^■T- —PLQ- -FAKDSYDEDLEN 278

WP 015058523 213 LTDK- ISKSAKKDRILAQ- ^■Y- PN QKSTGI FAEFLKLIVGNQADFKKHF- -NLEDK- -T- —PLQ- -FAKDSYDEDLEN 278

WP 017643650 213 LTDK- ISKSAKKDRILAR- ^■Y- PN QKSTGI FAEFLKLIVGNQADFKKHF- -NLEDK- ^■T- —PLQ- -FAKDSYDEDLEN 278

WP 017647151 213 LTDK- ISKSAKKDRILAQ- ^■Y- PN QKSTGI FAEFLKLIVGNQADFKKHF- -NLEDK- ^■T- —PLQ- -FAKDSYDEDLEN 278

WP 017648376 213 LTDK- ISKSAKKDRILAQ- ^■Y- PN QKSTGI FAEFLKLIVGNQADFKKHF- -NLEDK- ^■T- —PLQ- -FAKDSYDEDLEN 278

WP 017649527 213 LTDK- ISKSAKKDRILAQ- ^■Y- PN QKSTGI FAEFLKLIVGNQADFKKYF- -NLEDK- ^■T- —PLQ- -FAKDSYDEDLEN 278

WP 017771611 213 LTDK- ISKSAKKDRILAQ- ^■Y- PN QKSTGI FAEFLKLIVGNQADFKKHF- -NLEDK- ^■T- —PLQ- -FAKDSYDEDLEN 278

WP 017771984 213 LTDK- ISKSAKKDRILAQ- ^■Y- PN QKSTGI FAEFLKLIVGNQADFKKYF- -NLEDK- ^■T- —PLQ- -FAKDSYDEDLEN 278

CFQ25032 213 LTDK- ISKSAKKDRILAQ- ^■Y- PN QKSTGI FAEFLKLIVGNQADFKKYF- -NLEDK- ^■T- —PLQ- -FAKDSYDEDLEN 278

CFV16040 213 LTDK- ISKSAKKDRILAQ- ^■Y- PN QKSTGI FAEFLKLIVGNQADFKKYF- -NLEDK- ^■T- —PLQ- -FAKDSYDEDLEN 278

KLJ37842 213 LTDK- ISKSAKKDRILAQ- ^■Y- PN QKSTGI FAEFLKLIVGNQADFKKYF- -NLEDK- ^■T- —PLQ- -FAKDSYDEDLEN 278

KLJ72361 213 LTDK- ISKSAKKDRILAQ- ^■Y- PN QKSTGI FAEFLKLIVGNQADFKKYF- -NLEDK- -T- —PLQ- -FAKDSYDEDLEN 278

KLL20707 213 LTDK- ISKSAKKDRILAQ- ^■Y- PN QKSTGI FAEFLKLIVGNQADFKKYF- -NLEDK- ^■T- —PLQ- -FAKDSYDEDLEN 278

KLL42645 213 LTDK- ISKSAKKDRILAQ- ^■Y- PN QKSTGI FAEFLKLIVGNQADFKKHF- -NLEDK- ^■T- —PLQ- -FAKDSYDEDLEN 278

WP 047207273 213 LTDK- ISKSAKKDRILAQ- ^■Y- PN QKSTGI FAEFLKLIVGNQADFKKYF- -NLEDK- ^■T- —PLQ- -FAKDSYDEDLEN 278

WP 047209694 213 LTDK- ISKSAKKDRILAR- ^■Y- PN QKSTGI FAEFLKLIVGNQADFKKHF- -NLEDK- ^■T- —PLQ- -FAKDSYDEDLEN 278

WP 050198062 213 LTDK- ISKSAKKDRILAQ- ^■Y- PN QKSTGI FAEFLKLIVGNQADFKKYF- -NLEDK- ^■T- —PLQ- -FAKDSYDEDLEN 278

WP 050201642 213 LTDK- ISKSAKKDRILAQ- ^■Y- PN QKSTGI FAEFLKLIVGNQADFKKYF- -NLEDK- ^■T- —PLQ- -FAKDSYDEDLEN 278

WP 050204027 213 LTDK- ISKSAKKDRILAQ- ^■Y- PN QKSTGI FAEFLKLIVGNQADFKKHF- -NLEDK- ^■T- —PLQ- -FAKDSYDEDLEN 278

WP 050881965 213 LTDK- ISKSAKKDRILAQ- ^■Y- PN QKSTGI FAEFLKLIVGNQADFKKYF- -NLEDK- ^■T- —PLQ- -FAKDSYDEDLEN 278

WP 050886065 213 LTDK-^■ISKSAKKDRILAQ-^■Y- PN QKSTGI FAEFLKLIVGNQADFKKYF--NLEDK--T---PLQ--FAKDSYDEDLEN 278

AHN30376 213 LTDK- ^■ISKSAKKDRILAQ- ^■Y- PN QKSTGI FAEFLKLIVGNQADFKKHF- -NLEDK- -T- - -PLQ- -FAKDSYDEDLEN 278

EA078426 213 LTDK- ^■ISKSAKKDRILAQ- ^■Y- PN QKSTGI FAEFLKLIVGNQADFKKYF- -NLEDK- -T- - -PLQ- -FAKDSYDEDLEN 278

CCW42055 213 LTDK- ^■ISKSAKKDRILAQ- ^■Y- PD QKSTGI FAEFLKLIVGNQADFKKHF- -NLEDK- -T- - -PLQ- -FAKDSYDEDLEN 278

WP 0030415 02 212 LTEK- ^■VSKSRRLENLIAH- ^■Y- PA EKKNTLFGNLIALFLGLQPNFKTNF- -QLSED- -A- - -KLQ- -FSKDTYEEDLEG 277

WP 0375937 52 213 LTEK- ^■VSKSSRLENLIAH- ^■Y- PT EKKNTLFGNLIALSLGLQPNFKTNF- -QLSED- -A- - -KLQ- -FSKDTYEEDLEE 278

WP 0495166 84 213 LTEK- ^■VSKSRRLENLVEC- ^■Y- PT EKKNTLFGNLIALSLGLQPNFKTNF- -QLSED- -A- - -KLQ- -FSKDTYEEDLEG 278

GAD46167 212 LTEK- ^■VSKSSRLENLIAH- ^■Y- PT EKKNTLFGNLIALSLGLQPNFKTNF- -QLSED- -A- - -KLQ- -FSKDTYEEDLEE 277

WP 0183634 70 213 LTEK- ^■ISKSRRLENLINN- ^■Y- PK EKKNTLFGNLIALALGLQPNFKTNF- -KLSED- -A- - -KLQ- -FSKDTYEEDLEE 278

WP 0030438 19 212 LSAR- ^■LSKSKRLEKLIAV- ^■F- PN EKKNGLFGNIIALALGLTPNFKSNF- -DLTED- -A- - -KLQ- -LSKDTYDDDLDE 277

WP 0062696 58 212 LTEK- ^■VSKSSRLENLIAH- ^■Y- PT EKKNTLFGNLIALSLDLHPNFKTNF- -QLSED- -A- - -KLQ- -FSKDTYEEDLEG 277

WP 0488008 89 212 LTEK- ^■VSKSRRLENLVKC- ^■Y- PT EKKNTLFGNLIALSLGLQPNFKTNF- -QLSED- -A- - -KLQ- -FSKDTYEEDLEE 277

WP 0127671 06 212 LSAR- ^■LSKSRRLENLIAQ- ^■L- PG EKRNGLFGNLIALSLGLTPNFKSNF- -DLAED- -A- - -KLQ- -LSKDTYDDDLDN 277

WP 0146123 33 212 LSAR- ^■LSKSKRLENLIAQ- ^■L- PG EKKNGLFGNLIALSLGLTPNFKSNF- -DLAED- -A- - -KLQ- -LSKDTYDDDLDN 277

WP 0150170 95 212 LSAR- ^■LSKSRRLENLIAQ- ^■L- PG EKRNGLFGNLIALSLGLTPNFKSNF- -DLAED- -A- - -KLQ- -LSKDTYDDDLDN 277

WP 0150576 49 212 LSAR- ^■LSKSRRLENLIAQ- ^■L- PG EKRNGLFGNLIALSLGLTPNFKSNF- -DLAED- -A- - -KLQ- -LSKDTYDDDLDN 277

WP 0483272 15 212 LSAR- ^■LSKSRRLENLIAQ- ^■L- PG EKRNGLFGNLIALSLGLTPNFKSNF- -DLAED- -A- - -KLQ- -LSKDTYDDDLDN 277

WP 0495193 24 212 LSAR- ^■LSKSRRLENLIAQ- ^■L- PG EKRNGLFGNLIALSLGLTPNFKSNF- -DLAED- -A- - -KLQ- -LSKDTYDDDLDN 277

WP 0125159 31 212 LSAA- ^■LSKSKRLENLISL- ^■I- PG QKKTGIFGNIIALSLGLTPNFKANF- -GLSKD- -V- - -KLQ- -LAKDTYADDLDS 277

WP 0213209 64 212 LSAA- ^■LSKSKRLENLISL- ^■I- PG QKKTGIFGNIIALSLGLTPNFKANF- -GLSKD- -V- - -KLQ- -LAKDTYADDLDS 277

WP 0375817 60 212 LSAA- ^■LSKSKRLENLISL- ^■I- PG QKKTGIFGNIIALSLGLTPNFKANF- -GLSKD- -V- - -KLQ- -LAKDTYADDLDS 277

WP 0042324 81 212 LTEK- ^■ISKSRRLENLIKQ- ^■Y- PT EKKNTLFGNLVALALGLQPNFKTNF- -KLSED- -A- - -KLQ- -FSKDTYDEDLEE 277

WP 0098545 40 213 LTEK- ^■ISKSRRLENLIKY- ^■Y- PT EKKNTLFGNLIALALGLQPNFKMNF- -KLSED- -A- - -KLQ- -FSKDTYEEDLEE 278

WP 0129621 74 213 LTEK- ^■FSKSRRLENLIKH- ^■Y- PT EKKNTLFGNLVALALGLQPNFKTSF- -KLSED- -A- - -KLQ- -FSKDTYEEDLEE 278

WP 0396953 03 213 LTEK- ^■ISKSRRLENLIKY- ^■Y- PT EKKNTLFGNLIALALGLQPNFKTNF- -KLSED- -A- - -KLQ- -FSKDTYEEDLEE 278

WP 0143349 83 212 LTEK- ^■VSKSRRLENLIKQ- ^■Y- PT EKKNTLFGNLIALALGLQPNFKTNF- -KLSED- -A- - -KLQ- -FSKDTYEEDLEE 277

WP 0030992 69 212 LTSK- ^■TSKSRRLENLIAE- ^■I- PN QKRNMLFGNLVSLALGLTPNFKTNF- -ELLED- -A- - -KLQ- -ISKDSYEEDLDN 277

AHY15608 212 LTSK- ^■TSKSRRLENLIAE- ^■I- PN QKRNMLFGNLVSLALGLTPNFKTNF- -ELLED- -A- - -KLQ- -ISKDSYEEDLDN 277

AHY17476 212 LTSK- ^■TSKSRRLENLIAE- ^■I- PN QKRNMLFGNLVSLALGLTPNFKTNF- -ELLED- -A- - -KLQ- -ISKDSYEEDLDN 277

ESR09100

AGM98575 212 LTSK- ^■TSKSRRLENLIAE- ^■I- PN QKRNMLFGNLVSLALGLTPNFKTNF- -ELLED- -A- - -KLQ- -ISKDSYEEDLDN 277

ALF27331 212 LTDK- ^■ISKSAKKDRVLKL- ^■F- PN EKSNGRFAEFLKLIVGNQADFKKHF- -ELEEK- -A- - -PLQ- -FSKDTYEEELEV 277

WP 0183724 92 210 FTEN- ^■SSKAKRVETILGL- ^■F- PD ETAAGNLDKFLKLMLGNQADFKKVF- -DLEEK- -iTLQ- -FSKDSYEEDLEL 275

WP 0456180 28 213 FTDK- ^■ISKSAKRERVLKL- ^■F- PD EKSTGLFSEFLKLIVGNQADFKKHF- -DLEEK- -A- - -PLQ- -FSKDTYDEDLEN 278

WP 0456351 97 212 FTDK- ^■ISKSAKRERVLKL- ^■F- PD EKSTGLFSEFLKLIVGNQADFKKHF- -DLEDK- -A- - -PLQ- -FSKDTYDEDLEN 277

WP 0022635 49 212 LTDK- ^■ISKSAKKDRVLKL- ^■F- PN EKSNGRFAEFLKLIVGNQADFKKHF- -ELEEK- -A- - -PLQ- -FSKDTYEEELEV 277

WP 0022638 87 212 LTDK- ^■ISKSAKKDRVLKL- ^■F- PN EKSNGRFAEFLKLIVGNQADFKKHF- -ELEEK- -A- - -PLQ- -FSKDTYEEELEV 277

WP 0022649 20 212 LTEK- ^■ISKSRRLEKLINN- ^■Y- PK EKKNTLFRNLVALSLGLQPNFKTNF- -KLSED- -A- - -KLQ- -FSKDTYEEDLEE 277

WP 0022690 43 212 LTDK- ^■ISKSAKKDRVLKL- ^■F- PN EKSNGRFAEFLKLIVGNQADFKKHF- -ELEEK- -A- - -PLQ- -FSKDTYEEELEV 277

WP 002269448 212 LTDK- ISKSAKKDRVLKL-^■F-^■PN EKSNGRFAEFLKLIVGNQADFKKHF--ELEEK--A-—PLQ--FSKDTYEEELEV 277

WP ^"002271977 212 LTDK- ISKSAKKDRVLKL- ^■F- ^■PN EKSNGRFAEFLKLIVGNQADFKKHF- -ELEEK- -A- —PLQ- -FSKDTYEEDLEE 277

WP ^"002272766 212 LTDK- ISKSAKKDRVLKL- ^■F- PN EKSNGRFAEFLKLIVGNQADFKKHF- -ELEEK- -A- —PLQ- -FSKDTYEEDLEE 277

WP ^"002273241 212 LTDK- ISKSAKKDRVLKL- F- PN EKSNGRFAEFLKLIVGNQADFKKHF- -ELEEK- -A- —PLQ- -FSKDTYEEELEV 277

WP ^"002275430 212 LTDK- ISKSAKKDRVLKL- F- PN EKSNGRFAEFLKLIVGNQADFKKHF- -ELEEK- -A- —PLQ- -FSKDTYEEELEV 277

WP ^"002276448 212 LTDK- ISKSAKKDRVLKL- F- PN EKSNGRFAEFLKLIVGNQADFKKHF- -ELEEK- -A- —PLQ- -FSKDTYEEELEV 277

WP ^"002277050 212 LTEK- ISKSRRLEKLINN- ^■Y- PK EKKNTLFGNLIALSLGLQPNFKTNF- -KLSED- -A- —KLQ- -FSKDTYEEDLEE 277

WP ^"002277364 212 LTDK- ISKSAKKDRVLKL- F- PN EKSNGRFAEFLKLIVGNQADFKKHF- -ELEEK- -A- —PLQ- -FSKDTYEEELEV 277

WP ^"002279025 212 LTDK- ISKSAKKDRVLKL- F- PN EKSNGRFAEFLKLIVGNQADFKKHF- -ELEEK- -A- —PLQ- -FSKDTYEEELEV 277

WP ^"002279859 212 LTEK- ISKSRRLEKLINN- ^■Y- PK EKKNTLFGNLIALSLGLQPNFKTNF- -KLSED- -A- —KLQ- -FSKDTYEEELEV 277

WP ^"002280230 212 LTDK- ISKSAKKDRVLKL- F- PN EKSNGRFAEFLKLIVGNQADFKKHF- -ELEEK- -A- —PLQ- -FSKDTYEEELEV 277

WP ^"002281696 212 LTDK- ISKSAKKDRVLKL- F- PN EKSNGRFAEFLKLIVGNQADFKKHF- -ELEEK- -A- —PLQ- -FSKDTYEEELEV 277

WP ^"002282247 212 LTEK- ISKSRRLEKLINN- ^■Y- PK EKKNTLFGNLIALSLGLQPNFKTNF- -KLSED- -A- —KLQ- -FSKDTYEEDLEE 277

WP ^"002282906 212 LTDK- ISKSAKKDRVLKL- F- PN EKSNGRFAEFLKLIVGNQADFKKHF- -ELEEK- -A- —PLQ- -FSKDTYEEELEV 277

WP ^"002283846 212 LTDK- ISKSAKKDRVLKL- ^■F- PN EKSNGRFAEFLKLIVGNQADFKKHF- -ELEEK- -A- —PLQ- -FSKDIYEEELEV 277

WP ^"002287255 212 LTDK- ISKSAKKDRVLKL- F- PN EKSNGRFAEFLKLIVGNQADFKKHF- -ELEEK- -A- —PLQ- -FSKDTYEEELEV 277

WP ^"002288990 212 LTDK- ISKSAKKDRVLKL- F- PN EKSNGRFAEFLKLIVGNQADFKKHF- -ELEEK- -A- —PLQ- -FSKDIYEEELEV 277

WP ^"002289641 212 LTDK- ISKSAKKDRVLKL- F- PN EKSNGCFAEFLKLIVGNQADFKKHF- -ELEEK- -A- —PLQ- -FSKDTYEEELEV 277

WP ^"002290427 212 LTDK- ISKSAKKDRVLKL- F- PN EKSNGRFAEFLKLIVGNQADFKKHF- -ELEEK- -A- —PLQ- -FSKDIYEEELEV 277

WP ^"002295753 212 LTDK- ISKSAKKDRVLKL- F- PN EKSNGRFAEFLKLIVGNQADFKKHF- -ELEEK- -A- —PLQ- -FSKDTYEEELEV 277

WP ^"002296423 212 LTDK- ISKSAKKDRVLKL- F- PN EKSNGRFAEFLKLIVGNQADFKKHF- -ELEEK- -A- —PLQ- -FSKDIYEEELEV 277

WP ^"002304487 212 LTEK- VSKSRRLENLVEC- ^■Y- PT EKKNTLFGNLIALSLGLQPNFKTNF- -QLSED- -A- —KLQ- -FSKDTYEEDLEG 277

WP ^"002305844 212 LTDK- ISKSAKKDRVLKL- F- PN EKSNGRFAEFLKLIVGNQADFKKHF- -ELEEK- -A- —PLQ- -FSKDTYEEELEV 277

WP ^"002307203 212 LTDK- ISKSAKKDRVLKL- F- PN EKSNGRFAEFLKLIVGNQADFKKHF- -ELEEK- -A- —PLQ- -LSKDTYEEELEV 277

WP ^"002310390 212 LTDK- ISKSAKKDRVLKL- F- PN EKSNGRFAEFLKLIVGNQADFKKHF- -ELEEK- -A- —PLQ- -FSKDIYEEELEV 277

WP ^"002352408 212 LTDK- ISKSAKKDRVLKL- F- PN EKSNGRFAEFLKLIVGNQADFKKHF- -ELEEK- -A- —PLQ- -FSKDIYEEELEV 277

WP ^"012997688 212 LTDK- ISKSAKKDRVLKL- F- PN EKSNGRFAEFLKLIVGNQADFKKHF- -ELEEK- -A- —PLQ- -FSKDTYEEELEV 277

WP ^"014677909 212 LTDK- ISKSAKKDRVLKL- F- PN EKSNGRFAEFLKLIVGNQADFKKHF- -ELEEK- -A- —PLQ- -FSKDIYEEELEV 277

WP ^"019312892 212 LTDK- ISKSAKKDRVLKL- F- PN EKSNGRFAEFLKLIVGNQADFKKHF- -ELEEK- -A- —PLQ- -FSKDTYEEELEV 277

WP ^"019313659 212 LTDK- ISKSAKKDRVLKL- F- PN EKSNGRFAEFLKLIIGNQADFKKHF- -ELEEK- -A- —PLQ- -FSKDTYEEELEV 277

WP ^"019314093 212 LTDK- ISKSAKKDRVLKL- F- PN EKSNGRFAEFLKLIVGNQADFKKHF- -ELEEK- -A- —PLQ- -LSKDTYEEELEV 277

WP ^"019315370 212 LTDK- ISKSAKKDRVLKL- F- PN EKSNGRFAEFLKLIVGNQADFKKHF- -ELEEK- -A- —PLQ- -FSKDTYEEELEV 277

WP ^"019803776 212 LTDK- ISKSAKKDRVLKL- F- PN EKSNGRFAEFLKLIVGNQADFKKHF- -ELEEK- -V- —PLQ- -FSKDTYEEELEV 277

WP ^"019805234 212 LTDK- ISKSAKKDRVLKL- F- PN EKSNGRFAEFLKLIVGNQADFKKHF- -ELEEK- -A- —PLQ- -FSKDIYEEELEV 277

WP ^"024783594 212 LTDK- ISKSAKKDRVLKL- F- PN EKSNGRFAEFLKLIVGNQADFKKHF- -ELEEK- -A- —PLQ- -FSKDTYEEELEV 277

WP ^"024784288 212 LTEK- ISKSRRLEKLINN- ^■Y- PK EKKNTLFGNLIALSLGLQPNFKTNF- -KLSED- -A- —KLQ- -FSKDTYEEDLEE 277

WP ^"024784666 212 LTDK- ISKSAKKDRVLKL- F- PN EKSNGRFAEFLKLIVGNQADFKKHF- -ELEEK- -A- —PLQ- -FSKDTYEEELEV 277

WP ^"024784894 212 LTDK- ISKSAKKDRVLKL- F- PN EKSNGRFAEFLKLIVGNQADFKKHF- -ELEEK- -A- —PLQ- -FSKDTYEEELEV 277

WP ^"024786433 212 LTEK- ISKSRRLEKLINN- ^■Y- PK EKKNTLFGNLIALSLGLQPNFKTNF- -KLSED- -A- —KLQ- -FSKDTYEEDLEE 277

WP 049473442 212 LTDK--ISKSAKKDRVLKL-^■F-^■PN EKSNGRFAEFLKLIVGNQADFKKHF--ELEEK--A—-PLQ--FSKDTYEEDLEE 277

WP 049474547 212 LTDK- -ISKSAKKDRVLKL- ^■F- ^■PN EKSNGRFAEFLKLIVGNQADFKKHF- -ELEEK- -A— -PLQ- -FSKDTYEEELEV 277

EMC03581 205 LTDK- -ISKSAKKDRVLKL- ^■F- PN EKSNGRFAEFLKLIVGNQADFKKHF- -ELEEK- -A— -PLQ- -FSKDTYEEELEV 270

WP 000428612 213 FTDK- -ISKSAKRERVLKL- F- ^■PD EKSTGLFSEFLKLIVGNQADFKKHF- -DLEEK- -A— -PLQ- -FSRDTYDEDLEN 278

WP 000428613 213 FTDK- -ISKSAKRERVLKL- F- ^■PD EKSTGLFSEFLKLIVGNQADFKKHF- -DLGEK- -A— -PLQ- -FSKDTYDEDLEN 278

WP 049523028 212 FTDK- -ISKSAKRDRVLKL- F- ^■PD EKSTGLFSEFLKLIVGNQADFKKHF- -DLEEK- -A— -PLQ- -FSKDTYEEDLES 277

WP 003107102 181 LTEK- -MSKSRRLENLIAK- ^■I- PN QKKNTLFGNLISLSLGLTPNFKANF- -ELSED- -A— -KLQ- -ISKESFEEDLDN 246

WP 054279288 214 LTEK- -ISKTRRLENLISN- ^■I- ^■PG QKKNGLFGNLIALSLGLTPNFKSHF- -NLPED- -A— -KLQ- -LAKDTYDEELNN 279

WP 049531101 213 FTDK- -ISKSTKRERVLKL- ^■F- ^■PD QKSTGLFSEFLKLIVGNQADFKKHF- -DLEEK- -A— -PLQ- -FSKDTYDEDLEN 278

WP 049538452 213 FSDK- -ISKSAKRERVLKL- F- ^■PD EKSTGLFSEFLKLIVGNQADFKKHF- -DLEEK- -A— -PLQ- -FSKDTYDEDLEN 278

WP 049549711 213 FTDK- -ISKSAKRERVLKL- F- ^■PD EKSTGLFSEFLKLIVGNQADFKKHF- -DLGEK- -A— -PLQ- -FSKDTYDEDLEN 278

WP 007896501 214 LTAK- -TSKSKRLESLISE- F- ^■PG QKKNGLFGNLLALALGLRPNFKSNF- -GLSED- -A— -KLQ- -ITKDTYEEELDN 279

EFR44625 166 LTAK- -TSKSKRLESLISE- F- ^■PG QKKNGLFGNLLALALGLRPNFKSNF- -GLSED- -A— -KLQ- -ITKDTYEEELDN 231

WP 002897477 212 FTDK- -ISKSAKRERVLKL- ^■F- ^■PD EKSTGLFSEFLKLIVGNQADFKKHF- -DLEEK- -A— -PLQ- -FSKDTYDEELEN 277

WP 002906454 212 FTDK- -ISKSTKRERVLKL- F- ^■SD EKSTGLFSEFLKLIVGNQADFKKHF- -DLEEK- -A— -PLQ- -FSKDTYDEDLEN 277

WP 009729476 213 FTDK- -ISKSAKRERVLKL- F- ^■PD EKSTGLFSEFLKLIVGNQADFKKHF- -DLEEK- -A— -PLQ- -FSRDTYDEDLEN 278

CQR24647 212 ITAK- -ISKSRKVEAVLEQ- F- ^■PD QKKNSFFGNMVSLVFGLMPNFKSNF- -ELDED- -A— -KLQ- -FSRDSYDEDLEN 277

WP 000066813 213 FTDK- -ISKSTKRERVLKL- F- ^■PD EKSTGLFSEFLKLIVGNQADFKKHF- -DLEEK- -A— -PLQ- -FSKDTYDEDLEN 278

WP 009754323 213 FTGK- -ISKSVKREHVLKL- F- ^■PD EKSTGLFSEFLKLIVGNQADFKKHF- -DLEEK- -A— -SLQ- -FSKDTYDEDLEN 278

WP 044674937 212 LVEK- -VSKSRRLENILHY- F- PN EKKNGLFGNFLALALGLQPNFKTNF- -ELAED- -A— -KIQ- -FSKETYEEDLEE 277

WP 044676715 212 LVEK- -VSKSRRLENILHY- F- PN EKKNGLFGNFLTLALGLQPNFKTNF- -ELAED- -A— -KIQ- -FSKETYEEDLEE 277

WP 044680361 212 LVEK- -VSKSRRLENILHY- F- PN EKKNGLFGNFLALALGLQPNFKTNF- -ELAED- -A— -KIQ- -FSKETYEEDLEE 277

WP 044681799 212 LVEK- -VSKSRRLENILHY- F- PN EKKNGLFGNFLALALGLQPNFKTNF- -ELAED- -A— -KIQ- -FSKETYEEDLEE 277

WP 049533112 212 LTEK- -VSKSRRLENLIAH- ^■Y- PA EKKNTLFGNLIALSLGLQPNFKTNF- -QLSED- -A— -KLQ- -FSKDTYEEDLEG 277

WP 029090905 172 LLDRmMNRSSKVKFLIEL- ^■TG KQDKPLLKELFNLIVGLKAKPASIFe QENlAtivETM-nMSTEQVQLDLLT 243

WP 006506696 211 LKKP- -LSKKAKVDEVMTL- ^■IaPE KDYKSAFKELVTGIAGNKMNVTKMIlcEPIKQ- -Gds -EIK1kFSDSNYDDQFSE 283

AIT42264 212 LSAR- -LSKSRRLENLIAQ- ^■L- ^■PG EKKNGLFGNLIALSLGLTPNFKSNF- -DLAED- -A— -KLQ- -LSKDTYDDDLDN 277

WP 034440723 218 FKQD- -ISRSKKLDQAIAL- ^■F- ^■QG -KRQSLFGIFLTLIVGNKANFQKIF- -NLEDD- iKLD- -LKEEDYDENLEE 283

AKQ21048 212 LSAR- -LSKSRRLENLIAQ- ^■L- ^■PG EKKNGLFGNLIALSLGLTPNFKSNF- -DLAED- -A— -KLQ- -LSKDTYDDDLDN 277

WP 004636532 211 LSSK- -QSRSRKHEQIMAL- ^■F- PN ENKLGNFGRFMMLIVGNTSNFKPVF- -DLDDE- -Y— -KLK- -LSDETYEEDLDT 276

WP 002364836 218 LTEK- -ASRTKKSEKVLQQ- ^■F- PQ EKANGLFGQFLKLMVGNKADFKKVF- -GLEEE- -A— -KI—tYASESYEEDLEG 283

WP 016631044 169 LTEK- -ASRTKKSEKVLQQ- ^■F- PQ EKANGLFGQFLKLMVGNKADFKKVF- -GLEEE- -A— -KI—tYASESYEEDLEG 234

EMS75795 1 -A— -KIQ- -LSKESYEEELES 20

WP 002373311 218 LTEK- -ASRTKKSEKVLQQ- ^■F- PQ EKANGLFGQFLKLMVGNKADFKKVF- -GLEEE- -A— -KI—tYASESYEEDLEG 283

WP 002378009 218 LTEK- -ASRTKKSEKVLQQ- ^■F- PQ EKANGLFGQFLKLMVGNKADFKKVF- -GLEEE- -A— -KI—tYASESYEEDLEG 283

WP 002407324 218 LTEK- -ASRTKKSEKVLQQ- ^■F- PQ EKANGLFGQFLKLMVGNKADFKKVF- -GLEEE- -A— -KI—tYASESYEEDLEG 283

WP 002413717 218 LTEK- -ASRTKKSEKVLQQ- ^■F- PQ EKANGLFGQFLKLMVGNKADFKKVF- -GLEEE- -A— -KI—tYASESYEEDLEG 283

WP 010775580 218 LTEK- -ASRTKKSEKVLQQ- ^■F- PQ EKANGLFGQFLKLMVGNKADFKKVF- -GLEEE- -A— -KIKitYASESYEEDLEG 285

WP 010818269 218 LTEK- -ASRTKKSEKVLQQ- ^■F- PQ EKANGLFGQFLKLMVGNKADFKKVF- -GLEEE- -A— -KI—tYASESYEEDLEG 283

WP 010824395 218 LTEK--ASRTKKSEKVLQQ-^■F-^■PQ EKANGLFGQFLKLMVGNKADFKKVF--GLEEE--A-—KI—tYASESYEEDLEG 283

WP ^"016622645 218 LTEK- -ASRTKKSEKVLQQ- ^■F- ^■PQ EKANGLFGQFLKLMVGNKADFKKVF- -GLEEE- -A- —KI—tYASESYEEDLEG 2 83

WP ^"033624816 218 LTEK- -ASRTKKSEKVLQQ- ^■F- ^■PQ EKANGLFGQFLKLMVGNKADFKKVF- -GLEEE- -A- —KI—tYASESYEEDLEG 2 83

WP ^"033625576 218 LTEK- -ASRTKKSEKVLQQ- ^■F- ^■PQ EKANGLFGQFLKLMVGNKADFKKVF- -GLEEE- -A- —KI—tYASESYEEDLEG 2 83

WP ^"033789179 218 LTEK- -ASRTKKSEKVLQQ- ^■F- PQ EKANGLFGQFLKLMVGNKADFKKVF- -GLEEE- -A- —KI—tYASESYEEDLEG 2 83

WP ^"002310644 217 FTEK- -MSKTKKAETLLKY- ^■F- ^■PH EKSNGYLSQFIKLMVGNQGNFKNVF- -GL-EE- -A- —KLQ- -FSKETYEEDLEE 2 81

WP ^"002312694 217 FTEK- -MSKTKKAETLLKY- ^■F- PH EKSNGYLSQFIKLMVGNQGNFKNVF- -GL-EEeA- —KLQ- -FSKETYEEDLEE 2 82

WP ^"002314015 217 FTEK- -MSKTKKAETLLKY- ^■F- PH EKSNGYLSQFIKLMVGNQGNFKNVF- -GL-EEeA- —KLQ- -FSKETYEEDLEE 2 82

WP ^"002320716 217 FTEK- -MSKTKKAETLLKY- ^■F- PH EKSNGYLSQFIKLMVGNQGNFKNVF- -GL-EEeA- —KLQ- -FSKETYEEDLEE 2 82

WP ^"002330729 217 FTEK- -MSKTKKAETLLKY- ^■F- PH EKSNGYLSQFIKLMVGNQGNFKNVF- -GL-EE- -A- —KLQ- -FSKETYEEDLEE 2 81

WP ^"002335161 217 FTEK- -MSKTKKAETLLKY- ^■F- PH EKSNGYLSQFIKLMVGNQGNFKNVF- -GL-EEeA- —KLQ- -FSKETYEEDLEE 2 82

WP ^"002345439 217 FTEK- -MSKTKKAETLLKY- ^■F- PH EKSNGYLSQFIKLMVGNQGNFKNVF- -GL-EEeA- —KLQ- -FSKETYEEDLEE 2 82

WP ^"034867970 210 LTDK- -LSKTKKVEEILKY- ^■Y- PT EKINSFFAQCLKLIVGNQANFKRIF- -DLEAE- -V- —KLQ- -FSKETYEEDLES 2 75

WP ^"047937432 217 FTEK- -MSKTKKAETLLKY- ^■F- PH EKSNGYLSQFIKLMVGNQGNFKNVF- -GL-EEeA- —KLQ- -FSKETYEEDLEE 2 82

WP ^"010720994 210 LTDK- -LSKTKKVEEILKY- ^■Y- PT EKINSFFAQCLKLIVGNQANFKRIF- -DLEAE- -V- —KLQ- -FSKETYEEDLES 2 75

WP ^"010737004 210 LTDK- -LSKTKKVEEILKY- ^■Y- PT EKINSFFAQCLKLIVGNQANFKRIF- -DLEAE- -V- —KLQ- -FSKETYEEDLES 2 75

WP ^"034700478 210 LTDK- -LSKTKKVEEILKY- ^■Y- PT EKINSFFAQCLKLIVGNQANFKRIF- -DLEAE- -V- —KLQ- -FSKETYEEDLES 2 75

WP ^"007209003 215 LTQQ- -LSKSERADNVLKL- ^■F- ^■PD EKGTGIFAQFIKLIVGNQGNFKKVF- -QLEED- -qKLQ- -LSTDDYEENIEN 2 80

WP ^"023519017 210 LTER- -LSKAKRVEKVLAY- ^■Y- ^■PS EKSTGNFAQFLKLMVGNQANFKKTF- -DLEEE- -M- —KLN- -FTRDCYEEDLNE 2 75

WP ^"010770040 213 FSEK- -VSRARKVEAILSV- ^■Y- ^■SE EKSTGTLAQFLKLMVGNQGRFKKTF- -DLEED- -G- —IIQ- -IPKEEYEEELET 2 78

WP ^"048604708 209 FADK- -VSRAKKAEGVLAL- ^■F- ^■PD EKRNGTFDQFLKMIVGNQGNFKKTF- -ELEED- -A- —KLQ- -FSKEEYDESLEA 2 74

WP ^"010750235 210 LTDK- -LSKSKKVEKILQY- ^■Y- PK EKTTGCLAQFLKLIVGNQGNFKQAF- -HLDEE- -V- —KIQ- -ISKETYEEDLEK 2 75

AII16583 251 LSAR- -LSKSRRLENLIAQ- ^■L- ^■PG EKKNGLFGNLIALSLGLTPNFKSNF- -DLAED- -A- —KLQ- -LSKDTYDDDLDN 3 16

WP 029073316 216 LKEP- -LSKKHKADKAFAL- ^■FdTT KDNKAAYKELCAALAGNKFNVTKMLkeAELHD- -EdekDISfkFSDATFDDAFVE 2 89

WP ^"031589969 216 LKEP- -LSKKHKAEKAFAL- ^■FdTT KDNKAAYKELCAALAGNKFNVTKMLkeAELHD- -EdekDISfkFSDATFDDAFVE 2 89

KDA45870 210 FKDNtFSKTKKSEELLKL- ^■SG -KKNQLAHQLFKMMVGNMGSFKKVL- -GTDEE- -hKLS- -FGKDTYEDDLND 2 75

WP 039099354 207 LLDNhQSASNRQRQALLLiYtPS KQNKAIATELLKAILGLKAKFNVLT- -GIEAEdVktwTLT- -FNAENFDEEMVK 2 85

AKP02966 209 LIGR- -GNATQKSSNILNN- ^■F- -T KETKKLLKEVINLILGNVAHLNTIFktSLTKDeE- —KLS- -FSGKDIESKLDD 2 78

WP 010991369 218 LVEK- -VTRKEKLERILKL- ^■Y- ^■PG EKSAGMFAQFISLIVGSKGNFQKPF- -DLIEK- -S- —DIE- -CAKDSYEEDLES 2 83

WP ^"033838504 218 LVEK- -VTRKEKLERILKL- ^■Y- ^■PG EKSAGMFAQFISLIVGSKGNFQKPF- -DLIEK- -S- —DIE- -CAKDSYEEDLES 2 83

EHN60060 221 LVEK- -VTRKEKLERILKL- ^■Y- ^■PG EKSAGMFAQFISLIVGSKGNFQKPF- -DLIEK- -s- —DIE- -CAKDSYEEDLES 2 86

EFR89594 1 LKL- ^■Y- ^■PG EKSTGMFAQFISLIVGSKGNFQKPF- -DLIEK- -s- —DIE- -CAKDSYEEDLES 5 2

WP 038409211 218 LSEK- -LTRREKLDKILKL- ^■Y- ^■TG EKSTGMFARFINLIIGSKGDFKKVF- -DLDEK- -A- —EIE- -CAKDTYEEDLEA 2 83

EFR95520

WP 003723650 218 LAGK- -FTRREKFERILQL- ^■Y- ^■PG EKSTGMFAQFISLIVGSKGNFQKVF- -DLIEK- -T- —DIE- -CAKDSYEEDLET 2 83

WP ^"003727705 218 LAGK- -FTRREKFERILRL- ^■Y- ^■PG EKSTGMFAQFISLIVGNKGNFQKVF- -NLVEK- -T- —DIE- -CAKDSYEEDLEA 2 83

WP ^"003730785 218 LAGK- -FTRREKFERILRL- ^■Y- ^■PG EKSTGMFAQFISLIVGNKGNFQKVF- -NLVEK- -T- —DIE- -CAKDSYEEDLEA 2 83

WP ^"003733029 218 LAEK- -FTRKDKLDKILSL- ^■Y- ^■PG EKTTGVFAQF I IVGSTGKFKKHF- -NLHEK- -K- —DIN- -CAEDTYDTDLES 2 83

WP ^"003739838 218 LAGK- -FTRKEKLERILQL- ^■Y- ^■PG EKSTGMFAQFISLIVGSKGNFQKVF- -DLVEK- -T- —DIE- -CAKDSYEEDLEA 2 83

WP 014601172 218 LAGK- FTRREKFERILQL-^■Y- PG EKSTGMFAQFISLIVGSKGNFQKVF--DLIEK--T—-DIE--CAKDSYEEDLEA 283

WP 023548323 218 LAGK- FTRREKFERILQL- ^■Y- PG EKSTGMFAQFISLIVGSKGNFQKVF- -DLIEK- -T— -DIE- -CAKDSYEEDLET 283

WP 031665337 218 LAGK- FTRREKFERILQL- ^■Y- PG EKSTGMFAQFISLIVGSKGNFQKVF- -DLIEK- -T— -DIE- -CAKDSYEEDLET 283

WP 031669209 218 LAEK- FTRKDKLDKILSL- ^■Y- PG EKTTGVFAQF I IVGSTGKFKKHF- -NLHEK- -K— -DIN- -CAEDTYDTDLES 283

WP 033920898 218 LARK- FTRREKFERILQL- ^■Y- PG EKSTGMFAQFISLIVGSKGNFQKVF- -DLIEK- -T— -DIE- -CAKDSYEEDLET 283

AKI42028 221 LAGK- FTRREKFERILQL- ^■Y- PG EKSTGMFAQFISLIVGSKGNFQKVF- -DLIEK- -T— -DIE- -CAKDSYEEDLEA 286

AKI50529 221 LARK- FTRREKFERILQL- ^■Y- PG EKSTGMFAQFISLIVGSKGNFQKVF- -DLIEK- -T— -DIE- -CAKDSYEEDLET 286

EFR83390

WP 046323366 218 FSEK- LTKREKLDKILNL- ^■Y- PN EKSTDLFAQFI SLUGSKGNFKKFF- -NLTEK- -T— -DIE- -CAKDSYEEDLEV 283

AKE81011 228 LSAR- LSKSRRLENLIAQ- ^■L- PG EKKNGLFGNLIALSLGLTPNFKSNF- -DLAED- -A— -KLQ- -LSKDTYDDDLDN 293

CU082355 215 LKKP- LSKKAKVDEVMAL- ^■IsPE KEFKSAYKELVTGIAGNKMNVTKMIlcESIKQ- -Gds -EIKlkFSDSNYDDQFSE 287

WP 033162887 216 LSKI- YQRSKKADDLLKI- ^■MnPT KEEKAAYKEFTKALVGLKFNISKMIlaQEVKK- -Gdt -DIVleFSNANYDSTIDE 288

AGZ 01981 245 LSAR- LSKSRRLENLIAQ- ^■L- PG EKKNGLFGNLIALSLGLTPNFKSNF- -DLAED- -A— -KLQ- -LSKDTYDDDLDN 310

AKA60242 212 LSAR- LSKSRRLENLIAQ- ^■L- PG EKKNGLFGNLIALSLGLTPNFKSNF- -DLAED- -A— -KLQ- -LSKDTYDDDLDN 277

AKS40380 212 LSAR- LSKSRRLENLIAQ- ^■L- PG EKKNGLFGNLIALSLGLTPNFKSNF- -DLAED- -A— -KLQ- -LSKDTYDDDLDN 277

4UN5 B 216 LSAR- LSKSRRLENLIAQ- ^■L- PG EKKNGLFGNLIALSLGLTPNFKSNF- -DLAED- -A— -KLQ- -LSKDTYDDDLDN 281

WP 010922251 278 LLAQIGDQYADLFLAA[K]NLSDAILLSDILRVNTEITKAPLSASMIKRYDEHHQDLTLLKALVRQQ- LPEKYKEIFFDQSK 356

WP ^"039695303 279 LLGKIGDDYADLFTSAKNLYDAILLSGILTVDDNSTKAPLSASMIKRYVEHHEDLEKLKEFIKAN- KSELYHDIFKDKNK 357

WP ^"045635197 278 LLGQIGDDFTDLFVSAKKLYDAILLSGILTVTDPSTKAPLSASMIERYENHQNDLAALKQFIKNN- LPEKYDEVFSDQSK 356

5AXW A 158 LERLKKDG- EVR 168

WP 009880683 1 LSASMIKRYDEHHQDLTLLKALVRQQ- LPEKYKEIFFDQSK 40

WP ^"010922251 278 LLAQIGDQYADLFLAAKNLSDAILLSDI LRVNTEITKAPLSASMIKRYDEHHQDLTLLKALVRQQ- LPEKYKEIFFDQSK 356

WP ^"011054416 278 LLAQIGDQYADLFLAAKNLSDATLLSDILRVNSEITKAPLSASMIKRYDEHHQDLTLLKALVRQQ- LPEKYKEIFFDQSK 356

WP ^"011284745 278 LLAQIGDQYADLFLAAKNLSDAILLSDILRLNSEITKAPLSASMIKRYDEHHQDLTLLKALVRQQ- LPEKYKEIFFDQSK 356

WP ^"011285506 278 LLAQIGDQYADLFLAAKNLSDAILLSDILRVNTEITKAPLSASMIKRYDEHHQDLTLLKALVRQQ- LPEKYKEIFFDQSK 356

WP ^"011527619 278 LLAQIGDQYADLFLAAKNLSDAILLSDILRLNSEITKAPLSASMIKRYDEHHQDLTLLKALVRQQ- LPEKYKEIFFDQSK 356

WP ^"012560673 278 LLAQIGDQYADLFLAAKNLSDAILLSDILRVNTEITKAPLSASMIKRYDEHHQDLTLLKALVRQQ- LPEKYKEIFFDQSK 356

WP ^"014407541 278 LLAQIGDQYADLFLAAKNLSDAILLSDILRVNSEITKAPLSASMIKRYDEHHQDLTLLKALVRQQ- LPEKYKEIFFDQSK 356

WP ^"020905136 278 LLAQIGDQYADLFLAAKNLSDAILLSDILRLNSEITKAPLSASMIKRYDEHHQDLTLLKALVRQQ- LPEKYKEIFFDQSK 356

WP ^"023080005 278 LLAQIGDQYADLFLAAKNLSDAILLSDILRVNSEITKAPLSASMIKRYDEHHQDLTLLKALVRQQ- LPEKYKEIFFDQSK 356

WP ^"023610282 278 LLAQIGDQYADLFLAAKNLSDAILLSDILRVNSEITKAPLSASMIKRYDEHHQDLTLLKALVRQQ- LPEKYKEIFFDQSK 356

WP ^"030125963 278 LLAQIGDQYADLFLAAKNLSDAILLSDILRVNTEITKASLSASMIKRYDEHHQDLTLLKALVRQQ- LPEKYKEIFFDQSK 356

WP ^"030126706 278 LLAQIGDQYADLFLAAKNLSDATLLSDILRVNSEITKAPLSASMIKRYDEHHQDLTLLKALVRQQ- LPEKYKEIFFDQSK 356

WP ^"031488318 278 LLAQIGDQYADLFLAAKNLSDAILLSDILRVNSEITKAPLSASMIKRYDEHHQDLTLLKALVRQQ- LPEKYKEIFFDQSK 356

WP ^"032460140 278 LLAQIGDQYADLFLAAKNLSDAILLSDILRVNTEITKAPLSASMIKRYDEHHQDLTLLKALVRQQ- LPEKYKEIFFDQSK 356

WP ^"032461047 278 LLAQIGDQYADLFLAAKNLSDAILLSDILRVNTEITKAPLSASMIKRYDEHHQDLTLLKALVRQQ- LPEKYKEIFFDQSK 356

WP ^"032462016 278 LLAQIGDQYADLFLAAKNLSDAILLSDILRVNTEITKAPLSASMIKRYDEHHQDLTLLKALVRQQ- LPEKYKEIFFDQSK 356

WP ^"032462936 278 LLAQIGDQYADLFLAAKNLSDAILLSDILRVNSEITKAPLSASMIKRYDEHHQDLTLLKALVRQQ- LPEKYKEIFFDQSK 356

WP ^"032464890 278 LLAQIGDQYADLFLAAKNLSDAILLSDILRLNSEITKAPLSASMIKRYDEHHQDLTLLKALVRQQ- LPEKYKEIFFDQSK 356

WP ^"033888930 103 LLAQIGDQYADLFLAAKNLSDAILLSDILRVNTEITKAPLSASMIKRYDEHHQDLTLLKALVRQQ- LPEKYKEIFFDQSK 181

WP ^"038431314 278 LLAQIGDQYADLFLAAKNLSDATLLSDILRVNSEITKAPLSASMIKRYDEHHQDLTLLKALVRQQ- LPEKYKEIFFDQSK 356

WP ^"038432938 278 LLAQIGDQYADLFLAAKNLSDAILLSDILRVNSEITKAPLSASMIKRYDEHHQDLTLLKALVRQQ- LPEKYKEIFFDQSK 356

WP ^"038434062 278 LLAQIGDQYADLFLAAKNLSDAILLSDILRVNSEITKAPLSASMIKRYDEHHQDLTLLKALVRQQ- LPEKYKEIFFDQSK 356

BAQ51233 189 LLAQIGDQYADLFLAAKNLSDAILLSDILRVNTEITKAPLSASMIKRYDEHHQDLTLLKALVRQQ- LPEKYKEIFFDQSK 267

KGE60162

KGE60856

WP 002989955 278 LLAQIGDQYADLFLAAKNLSDAILLSDI LRLNSEITKAPLSASMIKRYDEHHQDLTLLKALVRQQ- ^■LPEKYKEIFFDQSK 356

WP ^"003030002 278 LLGEIGDEYADLFASAKNLYDAILLSGILTVDDNSTKAPLSASMVKRYEEHQKDLKKLKDFIKVN- ^■APDQYNAIFKDKNK 356

WP ^"003065552 281 LLGKIGDDYADLFTSAKNLYDAILLSGILIVDDNSTKAPLSASMIKRYVEHQEDLEKLKEFIKAN- ^■KSELYHDIFKDKNK 359

WP ^"001040076 279 LLGQIGDEFADLFSAAKKLYDSVLLSGILTVTDLSTKAPLSASMIQRYDEHREDLKQLKQFVKAS- ^■LPEKYQEIVADSSK 357

WP ^"001040078 279 LLGQIGDEFADLFSAAKKLYDSVLLSGILTVIDLSTKAPLSASMIQRYDEHREDLKQLKQFVKAS- ^■LPEKYQEIFADSSK 357

WP ^"001040080 279 LLGQIGDEFADLFSAAKKLYDSVLLSGILTVIDLSTKAPLSASMIQRYDEHREDLKQLKQFVKAS- ^■LPEKYQEIFADSSK 357

WP ^"001040081 279 LLGQIGDEFADLFSAAKKLYDSVLLSGILTVIDLSTKAPLSASMIQRYDEHREDLKQLKQFVKAS- ^■LPEKYQEIFADSSK 357

WP ^"001040083 279 LLGQIGDEFADLFSAAKKLYDSVLLSGILTVIDLSTKAPLSASMIQRYDEHREDLKQLKQFVKAS- ^■LPEKYQEIFADSSK 357

WP ^"001040085 279 LLGQIGDEFADLFSAAKKLYDSVLLSGILTVIDLSTKAPLSASMIQRYDEHREDLKQLKQFVKAS- ^■LPEKYQEIFADSSK 357

WP 001040087 279 LLGQIGDEFADLFSAAKKLYDSVLLSGILTVIDLSTKAPLSASMIQRYDEHREDLKQLKQFVKAS--LPEKYQEIFADSSK 357

WP ^"001040088 279 LLGQIGDEFADLFSAAKKLYDSVLLSGILTVIDLSTKAPLSASMIQRYDEHREDLKQLKQFVKAS- -LPEKYQEIFADSSK 357

WP ^"001040089 279 LLGQIGDEFADLFSAAKKLYDSVLLSGILTVIDLSTKAPLSASMIQRYDEHREDLKQLKQFVKAS- -LPEKYQEIFADSSK 357

WP ^"001040090 279 LLGQIGDEFADLFSAAKKLYDSVLLSGILTVIDLSTKAPLSASMIQRYDEHREDLKQLKQFVKAS- -LPEKYQEIFADSSK 357

WP ^"001040091 279 LLRQIGDEFADLFSAAKKLYDSVLLSGILTVIDLSTKAPLSASMIQRYDEHREDLKQLKQFVKAS- -LPEKYQEIFADSSK 357

WP ^"001040092 279 LLGQIGDEFADLFSAAKKLYDSVLLSGILTVTDLSTKAPLSAYMIQRYDEHREDLKQLKQFVKAS- -LPEKYQEIFADSSK 357

WP ^"001040094 279 LLGQIGDEFADLFSAAKKLYDSVLLSGILTVTDLSTKAPLSASMIQHYDEHREDLKQLKQFVKAS- -LPEKYQEIFADSSK 357

WP ^"001040095 279 LLGQIGDEFADLFSAAKKLYDSVLLSGILTVTDLSTKAPLSASMIQRYDEHREDLKQLKQFVKAS- -LPEKYQEIFADSSK 357

WP ^"001040096 279 LLGQIGDEFADLFSAAKKLYDSVLLSGILTVTDLSTKAPLSASMIQRYDEHREDLKQLKQFVKAS- -LPEKYQEIFADSSK 357

WP ^"001040097 279 LLGQIGDEFADLFSAAKKLYDSVLLSGILTVTDLSTKAPLSASMIQRYDEHREDLKQLKQFVKAS- -LPEKYQEIFADSSK 357

WP ^"001040098 279 LLGQIGDEFADLFSAAKKLYDSVLLSGILTVTDLSTKAPLSASMIQRYDEHREDLKQLKQFVKAS- -LPEKYQEIFADSSK 357

WP ^"001040099 279 LLGQIGDEFADLFSAAKKLYDSVLLSGILTVTDLSTKAPLSASMIQRYDEHREDLKQLKQFVKAS- -LPEKYQEIFADSSK 357

WP ^"001040100 279 LLGQIGDEFADLFSAAKKLYDSVLLSGILTVTDLSTKAPLSASMIQRYDEHREDLKQLKQFVKAS- -LPEKYQEIFADSSK 357

WP ^"001040104 279 LLGQIGDEFADLFSAAKKLYDSVLLSGILTVIDLSTKAPLSASMIQRYDEHREDLKQLKQFVKAS- -LPEKYQEIFADSSK 357

WP ^"001040105 279 LLGQIGDEFADLFSAAKKLYDSVLLSGILTVIDLSTKAPLSASMIQRYDEHREDLKQLKQFVKAS- -LPEKYQEIFADSSK 357

WP ^"001040106 279 LLGQIGDEFADLFSVAKKLYDSVLLSGILTVTDLSTKAPLSASMIQRYDEHREDLKQLKQFVKAS- -LPEKYQEIFTDSSK 357

WP ^"001040107 279 LLGQIGDEFADLFSVAKKLYDSVLLSGILTVTDLSTKAPLSASMIQRYDEHREDLKQLKQFVKAS- -LPEKYQEIFTDSSK 357

WP ^"001040108 279 LLGQIGDEFADLFSVAKKLYDSVLLSGILTVTDLSTKAPLSASMIQRYDEHREDLKQLKQFVKAS- -LPEKYQEIFTDSSK 357

WP ^"001040109 279 LLGQIGDEFADLFSVAKKLYDSVLLSGILTVTDLSTKAPLSASMIQRYDEHREDLKQLKQFVKAS- -LPEKYQEIFTDSSK 357

WP ^"001040110 279 LLGQIGDEFADLFSVAKKLYDSVLLSGILTVTDLSTKAPLSASMIQRYDEHREDLKQLKQFVKAS- -LPEKYQEIFTDSSK 357

WP ^"015058523 279 LLGQIGDEFADLFSAAKKLYDSVLLSGILTVTDLSTKAPLSASMIQRYDEHREDLKQLKQFVKAS- -LPEKYQEIFADSSK 357

WP ^"017643650 279 LLGQIGDEFADLFSAAKKLYDSVLLSGILTVTDLSTKAPLSASMIQRYDEHREDLKQLKQFVKAS- -LPEKYQEIFADSSK 357

WP ^"017647151 279 LLGQIGDEFADLFSVAKKLYDSVLLSGILTVTDLSTKAPLSASMIQRYDEHREDLKQLKQFVKAS- -LPEKYQEIFTDSSK 357

WP ^"017648376 279 LLGQIGDEFADLFSVAKKLYDSVLLSGILTVTDLSTKAPLSASMIQRYDEHREDLKQLKQFVKAS- -LPEKYQEIFTDSSK 357

WP ^"017649527 279 LLGQIGDEFADLFSAAKKLYDSVLLSGILTVIDLSTKAPLSASMIQRYDEHREDLKQLKQFVKAS- -LPEKYQEIFADSSK 357

WP ^"017771611 279 LLGQIGDEFADLFSVAKKLYDSVLLSGILTVTALSTKAPLSASMIQRYDEHREDLKQLKQFVKAS- -LPEKYQEIFTDSSK 357

WP ^"017771984 279 LLGQIGDEFADLFSAAKKLYDSVLLSGILTVIDLSTKAPLSASMIQRYDEHREDLKQLKQFVKAS- -LPEKYQEIFADSSK 357

CFQ25032 279 LLGQIGDEFADLFSAAKKLYDSVLLSGILTVIDLSTKASLSDSMIQRYDEHREDLKQLKQFVKAS- -LPEKYQEIFADSSK 357

CFV16040 279 LLGQIGDEFADLFSAAKKLYDSVLLSGILTVIDLSTKAPLSASMIQRYDEHREDLKQLKQFVKAS- -LPEKYQEIFADSSK 357

KLJ37842 279 LLGQIGDEFADLFSAAKKLYDSVLLSGILTVIDLSTKAPLSASMIQRYDEHREDLKQLKQFVKAS- -LPEKYQEIFADSSK 357

KLJ72361 279 LLGQIGDEFADLFSAAKKLYDSVLLSGILTVIDLSTKAPLSASMIQRYDEHREDLKQLKQFVKAS- -LPEKYQEIFADSSK 357

KLL20707 279 LLGQIGDEFADLFSAAKKLYDSVLLSGILTVIDLSTKAPLSASMIQRYDEHREDLKQLKQFVKAS- -LPEKYQEIFADSSK 357

KLL42645 279 LLGQIGDEFADLFSVAKKLYDSVLLSGILTVTDLSTKAPLSASMIQRYDEHREDLKQLKQFVKAS- -LPEKYQEIFTDSSK 357

WP 047207273 279 LLGQIGDEFADLFSAAKKLYDSVLLSGILTVIDLSTKAPLSASMIQRYDEHREDLKQLKQFVKAS- -LPEKYQEIFADSSK 357

WP ^"047209694 279 LLGQIGDEFADLFSAAKKLYDSVLLSGILTVTDLSTKAPLSASMIQRYDEHREDLKQLKQFVKAS- -LPEKYQEIFADSSK 357

WP ^"050198062 279 LLGQIGDEFADLFSAAKKLYDSVLLSGILTVIDLSTKAPLSASMIQRYDEHREDLKQLKQFVKAS- -LPEKYQEIFADSSK 357

WP ^"050201642 279 LLGQIGDEFADLFSAAKKLYDSVLLSGILTVIDLSTKAPLSASMIQRYDEHREDLKQLKQFVKAS- -LPEKYQEIFADSSK 357

WP ^"050204027 279 LLGQIGDEFADLFSVAKKLYDSVLLSGILTVTDLSTKAPLSASMIQRYDEHREDLKQLKQFVKAS- -LPEKYQEIFTDSSK 357

WP ^"050881965 279 LLGQIGDEFADLFSAAKKLYDSVLLSGILTVIDLSTKAPLSASMIQRYDEHREDLKQLKQFVKAS- -LPEKYQEIFADSSK 357

WP 050886065 279 LLGQIGDEFADLFSAAKKLYDSVLLSGILTVIDLSTKAPLSASMIQRYDEHREDLKQLKQFVKAS-LPEKYQEIFADSSK 357

AHN30376 279 LLGQIGDEFADLFSAAKKLYDSVLLSGILTVTDLSTKAPLSASMIQRYDEHREDLKQLKQFVKAS-LPEKYQEIFADSSK 357

EA078426 279 LLGQIGDEFADLFSAAKKLYDSVLLSGILTVIDLSTKAPLSASMIQRYDEHREDLKQLKQFVKAS-LPEKYQEIFADSSK 357

CCW42055 279 LLGQIGDEFADLFSAAKKLYDSVLLSGILTVTDLSTKAPLSASMIQRYDEHREDLKQLKQFVKAS-LPEKYQEIFADSSK 357

WP 003041502 278 LLGEVGDEYADLFASAKNLYDAILLSGILTVDDNSTKAPLSASMVKRYEEHQKDLKKFEDFIKVN-ALDQYNAIFKDKNK 356

WP 037593752 279 LLGEIGDEYADLFASAKNLYDAILLSGILAVDDNTTKAPLSASMVKRYEEHQKDLKKLKDFIKVN-APDQYNAIFKDKNK 357

WP 049516684 279 LLGEIGDEYADLFASAKNLYDAILLSGILAVDDNTTKAPLSASMVKRYEEHQKDLKKLKDFIKVN-APAQYDDIFKDETK 357

GAD46167 278 LLGEIGDEYADLFASAKNLYDAILLSGILAVDDNTTKAPLSASMVKRYEEHQKDLKKLKDFIKVN-APDQYNAIFKDKNK 356

WP 018363470 279 LLGKIGDDYADLFTSSKNLYDAILLSGILTVDDNSTKAPLSASMIKRYVEHHEDLEKLKEFIKAN-KSELYHDIFKDKTQ 357

WP 003043819 278 LLGQIGDQYADLFSAAKNLSDAILLSDILRSNSEVTKAPLSASMVKRYDEHHQDLALLKTLVRQQ-FPEKYAEIFKDDTK 356

WP 006269658 278 FLGEVGDEYADLFASAKNLYDAILLSGILTVDDNSTKAPLSASMVKRYEEHQKDLKKLKDFIKVN-APDQYNAIFKDKNK 356

WP 048800889 278 LLGKIGDDYADLFTSAKNLYDTILLSGILAVDDNSTKALLSASMIKRYEEHQKDLKKLKDFIKVN-APAQYDDIFKDETK 356

WP 012767106 278 LLAQIGDQYADLFLAAKNLSDAILLSDILRVNSEITKAPLSASMIKRYDEHHQDLTLLKALVRQQ-LPEKYKEIFFDQSK 356

WP 014612333 278 LLAQIGNQYADLFLAAKNLSDAILLSDILRVNSEITKAPLSASMIKRYDEHHQDLTLLKALVRQQ-LPEKYKEIFFDQSK 356

WP 015017095 278 LLAQIGDQYADLFLAAKNLSDAILLSDILRVNSEITKAPLSASMIKRYDEHHQDLTLLKALVRQQ-LPEKYKEIFFDQSK 356

WP 015057649 278 LLAQIGDQYADLFLAAKNLSDAILLSDILRVNSEITKAPLSASMIKRYDEHHQDLTLLKALVRQQ-LPEKYKEIFFDQSK 356

WP 048327215 278 LLAQIGDQYADLFLAAKNLSDAILLSDILRVNSEITKAPLSASMIKRYDEHHQDLTLLKALVRQQ-LPEKYKEIFFDQSK 356

WP 049519324 278 LLAQIGDQYADLFLAAKNLSDAILLSDILRVNSEITKAPLSASMIKRYDEHHQDLTLLKALVRQQ-LPEKYKEIFFDQSK 356

WP 012515931 278 LLAQIGDQYADLFLAAKNLSDAILLSDILTESDEITRAPLSASMVKRYREHHKDLVTLKTLIKDQ-LPEKYQEIFLDKTK 356

WP 021320964 278 LLAQIGDQYADLFLAAKNLSDAILLSDILTESDEITRAPLSASMVKRYREHHKDLVTLKTLIKDQ-LPEKYQEIFLDKTK 356

WP 037581760 278 LLAQIGDQYADLFLAAKNLSDAILLSDILTESDEITRAPLSASMVKRYREHHKDLVTLKTLIKDQ-LPEKYQEIFLDKTK 356

WP 004232481 278 LLGKIGDDYADLFTAAKNLYDAILLSGILTVDDNSTKAPLSASMIKRYEEHHEDLEKLKTFIKVN-NFDKYHEIFKDKSK 356

WP 009854540 279 LLGKIGDDYADLFTSAKNLYDAILLSGILTVDDNSTKAPLSASMIKRYVEHHEDLEKLKEFIKAN-KSELYHDIFKDKNK 357

WP 012962174 279 LIGKIGDEYADLFTSAKNLYDAILLSGILTVADNTTKAPLSASMIKRYNEHQVDLKKLKEFIKNN-ASDKYDEIFNDKDK 357

WP 039695303 279 LLGKIGDDYADLFTSAKNLYDAILLSGILTVDDNSTKAPLSASMIKRYVEHHEDLEKLKEFIKAN-KSELYHDIFKDKNK 357

WP 014334983 278 LLGKVGDDYADLFISAKNLYDAILLSGILTVDDNSTKAPLSASMIKRYVEHHEDLEKLKEFIKIN-KLKLYHDIFKDKTK 356

WP 003099269 278 LLAQIGDQYADLFIAAKKLSDAILLSDI ITVKGASTKAPLSASMVQRYEEHQQDLALLKNLVKKQ-IPEKYKEIFDNKEK 356

AHY15608 278 LLAQIGDQYADLFIAAKKLSDAILLSDI ITVKGASTKAPLSASMVQRYEEHQQDLALLKNLVKKQ-IPEKYKEIFDNKEK 356

AHY17476 278 LLAQIGDQYADLFIAAKKLSDAILLSDI ITVKGASTKAPLSASMVQRYEEHQQDLALLKNLVKKQ-IPEKYKEIFDNKEK 356

ESR09100

AGM98575 278 LLAQIGDQYADLFIAAKKLSDAILLSDI ITVKGASTKAPLSASMVQRYEEHQQDLALLKNLVKKQ- I PEKYKEI FDNKEK 356

ALF27331 278 LLAQIEDNYAELFLSAKKLYDSILLSGILTVTDVSTKAPLSASMIQRYNEHQMDLAQLKQFIRQK- LSDKYNEVFSDVSK 356

WP 018372492 276 LLSKIDEEYAALFDLAKKVYDAVLLSNILTVKEKNTKAPLSASMIKRYEEHKDDLKAFKRFFRER- LPEKYETMFKDLTK 354

WP 045618028 279 LLVQIGDDFADLFLVAKKLYDAILLSGILTVTDPSTKAPLSASMIDRYENHQKDLAALKQFIKTN- LPEKYDEVFSDQSK 357

WP 045635197 278 LLGQIGDDFTDLFVSAKKLYDAILLSGILTVTDPSTKAPLSASMIERYENHQNDLAALKQFIKNN- LPEKYDEVFSDQSK 356

WP 002263549 278 LLAQIGDNYAELFLSAKKLYDSILLSGILTVTDVGTKAPLSASMIQRYNEHQMDLAQLKQFIRQK- LSDKYNEVFSDVSK 356

WP 002263887 278 LLAQIGDNYAELFLSAKKLYDSILLSGILTVTDVGTKAPLSASMIQRYNEHQMDLAQLKQFIRQK- LSDKYNEVFSDVSK 356

WP 002264920 278 LLGKIGDDYADLFTLAKNLYDAILLSGILTADDSSTKAPLSASMIKRYAEHHEDLEKLKEFIKAN- KPELYHDIFKDETK 356

WP 002269043 278 LLAQIGDNYAELFLSAKKLYDSILLSGILTVTDVSTKAPLSASMIQRYNEHQMDLAQLKQFIRQK- LSDKYNEVFSDVSK 356

WP 002269448 278 LLAQIGDNYAELFLSAKKLYDSILLSGILTVTDVSTKAPLSASMIQRYNEHQMDLAQLKQFIRQK-^■LSDKYNEVFSDVSK 356

WP ^"0022 71977 278 LLGKIGDDYADLFTLAKNLYDAILLSGILTADDSSTKAPLSASMIQRYNEHQMDLAQLKQFIRQK- ^■LSDKYNEVFSDVSK 356

WP ^"0022 72766 278 LLGKIGDDYADLFTLAKNLYDAILLSGILTADDSSTKAPLSASMIQRYNEHQMDLAQLKQFIRQK- ^■LSDKYNEVFSDVSK 356

WP ^"0022 73241 278 LLAQIGDNYAELFLSAKKLYDSILLSGILTVTDVSTKAPLSASMIQRYNEHQMDLAQLKQFIRQK- ^■LSDKYNEVFSDVSK 356

WP ^"0022 75430 278 LLTQIGDNYAELFLSAKKLYDSILLSGILTVTDVSTKAPLSASMIQRYNEHQMDLAQLKQFIRQK- ^■LSDKYNEVFSDVSK 356

WP ^"0022 76448 278 LLAQIGDNYAELFLSAKKLYDSILLSGILTVTDVSTKAPLSASMIQRYNEHQMDLAQLKQFIRQK- ^■LSDKYNEVFSDVSK 356

WP ^"0022 77050 278 LLGKIGDDYADLFTLAKNLYDAILLSGILTADDSSTKAPLSASMIKRYAEHHEDLEKLKEFIKAN- ^■KPELYHDIFKDETK 356

WP ^"0022 77364 278 LLAQIGDNYAELFLSAKKLYDSILLSGILTVTDVSTKAPLSASMIQRYNEHQMDLAQLKQFIRQK- ^■LSDKYNEVFSDVSK 356

WP ^"0022 79025 278 LLAQIGDNYAELFLSAKKLYDSILLSGILTADDSSTKAPLSASMIQRYNEHQMDLAQLKQFIRQK- ^■LSDKYNEVFSDVSK 356

WP ^"0022 79859 278 LLAQIGDNYAELFLSAKKLYDSILLSGILTVTDVSTKAPLSASMIQRYNEHQMDLAQLKQFIRQK- ^■LSDKYNEVFSDVSK 356

WP ^"0022 80230 278 LLAQIGDNYAELFLSAKKLYDSILLSGILTVTDVSTKAPLSASMIQRYNEHQMDLAQLKQFIRQK- ^■LSDKYNEVFSDVSK 356

WP ^"0022 81696 278 LLAQIGDNYAELFLSAKKLYDSILLSGILTVTDVSTKAPLSASMIQRYNEHQMDLAQLKQFIRQK- ^■LSDKYNEVFSDVSK 356

WP ^"0022 82247 278 LLGKIGDDYADLFTLAKNLYDAILLSGILTADDSSTKAPLSASMIKRYAEHHEDLEKLKEFIKAN- ^■KPELYHDIFKDETK 356

WP ^"0022 82906 278 LLAQIGDNYAELFLSAKKLYDSILLSGILTVTDVGTKAPLSASMIQRYNEHQMDLAQLKQFIRQK- ^■LSDKYNEVFSDVSK 356

WP ^"0022 83846 278 LLAQIGDNYAELFLSAKKLYDSILLSGILTVTDVSTKAPLSASMIQRYNEHQMDLAQLKQFIRQK- ^■LSDKYNEVFSDVSK 356

WP ^"0022 87255 278 LLAQIGDNYAELFLSAKKLYDSILLSGILTVTDVSTKAPLSASMIQRYNEHQMDLAQLKQFIRQK- ^■LSDKYNEVFSDVSK 356

WP ^"0022 88990 278 LLAQIGDNYAELFLSAKKLYDSILLSGILTVTDVSTKAPLSASMIQRYNEHQMDLAQLKQFIRQK- ^■LSDKYNEVFSDVSK 356

WP ^"0022 89641 278 LLAQIGDNYAELFLSAKKLYDSILLSGILTVTDVSTKAPLSASMIQRYNEHQMDLTQLKQFIRQK- ^■LSDKYNEVFSDVSK 356

WP ^"0022 90427 278 LLAQIGDNYAELFLSAKKLYDSILLSGILTVTDVSTKAPLSASMIQRYNEHQMDLAQLKQFIRQK- ^■LSDKYNEVFSDVSK 356

WP ^"0022 95753 278 LLAQIGDNYAELFLSAKKLYDSILLSGILTVTDVSTKAPLSASMIQRYNEHQMDLAQLKQFIRQK- ^■LSDKYNEVFSDVSK 356

WP ^"0022 96423 278 LLAQIGDNYAELFLSAKKLYDSILLSGILTVTDVSTKAPLSASMIQRYNEHQMDLAQLKQFIRQK- ^■LSDKYNEVFSDVSK 356

WP ^"0023 04487 278 LLGEIGDEYADLFASAKNLYDAILLSGILAVDDNTTKAPLSASMVKRYKEHKEELAAFKRFIKEK- ^■LPKKYEEIFKDDTK 356

WP ^"0023 05844 278 LLAQIGDNYAELFLSAKKLYDSILLSGILTVTDVSTKAPLSASMIQRYNEHQMDLAQLKQFIRQK- ^■LSDKYNEVFSDVSK 356

WP ^"0023 07203 278 LLAQIGDNYAELFLSAKKLYDSILLSGILTVTDVSTKAPLSASMIQRYNEHQMDLAQLKQFIRQK- ^■LSDKYNEVFSDVSK 356

WP ^"0023 10390 278 LLAQIGDNYAELFLSAKKLYDSILLSGILTVTDVSTKAPLSASMIQRYNEHQMDLAQLKQFIRQK- ^■LSDKYNEVFSDVSK 356

WP ^"0023 52408 278 LLAQIGDNYAELFLSAKKLYDSILLSGILTVTDVSTKAPLSASMIQRYNEHQMDLAQLKQFIRQK- ^■LSDKYNEVFSDVSK 356

WP ^"0129 97688 278 LLAQIGDNYAELFLSAKKLYDSILLSGILTVTDVSTKAPLSASMIQRYNEHQMDLAQLKQFIRQK- ^■LSDKYNEVFSDVSK 356

WP ^"θ146 77909 278 LLAQIGDNYAELFLSAKKLYDSILLSGILTVTDVSTKAPLSASMIQRYNEHQMDLAQLKQFIRQK- ^■LSDKYNEVFSDVSK 356

WP ^"0193 12892 278 LLAQIGDNYAELFLSAKKLYDSILLSGILTVTDVSTKAPLSASMIQRYNEHQMDLAQLKQFIRQK- ^■LSDKYNEVFSDVSK 356

WP ^"0193 13659 278 LLAQIGDNYAELFLSAKKLYDSILLSGILTVTDVGTQAPLSASMIQRYNEHQMDLAQLKQFIRQK- ^■LSDKYNEVFSDVSK 356

WP ^"0193 14093 278 LLAQIGDNYAELFLSAKKLYDSILLSGILTVTDVSTKAPLSASMIQRYNEHQMDLAQLKQFIRQK- ^■LSDKYNEVFSDVSK 356

WP ^"0193 15370 278 LLAQIGDNYAELFLSAKKLYDSILLSGILTVTDVSTKAPLSASMIQRYNEHQMDLTQLKQFIRQK- ^■LSDKYNEVFSDVSK 356

WP ^"0198 03776 278 LLAQIGDNYAELFLSAKKLYDSILLSGILTVTDVGTKAPLSASMIQRYNEHQMDLAQLKQFIRQK- ^■LSDKYNEVFSDVSK 356

WP ^"0198 05234 278 LLAQIGDNYAELFLSAKKLYDSILLSGILTVTDVSTKAPLSASMIQRYNEHQMDLAQLKQFIRQK- ^■LSDKYNEVFSDVSK 356

WP ^"0247 83594 278 LLAQIGDNYAELFLSAKKLYDSILLSGILTVTDVGTKAPLSASMIQRYNEHQMDLAQLKQFIRQK- ^■LSDKYNEVFSDVSK 356

WP ^"0247 84288 278 LLGKIGDDYADLFTLAKNLYDAILLSGILTADDSSTKAPLSASMIKRYAEHHEDLEKLKEFIKAN- ^■KPELYHDIFKDETK 356

WP ^"0247 84666 278 LLAQIGDNYAELFLSAKKLYDSILLSGILTVTDVSTKAPLSASMIQRYNEHQMDLVQLKQFIRQK- ^■LSDKYNEVFSDVSK 356

WP ^"0247 84894 278 LLAQIGDNYAELFLSAKKLYDSILLSGILTVTDVSTKAPLSASMIQRYNEHQMDLTQLKQFIRQK- ^■LSDKYNEVFSDVSK 356

WP ^"0247 86433 278 LLGKIGDDYADLFTLAKNLYDAILLSGILTADDSSTKAPLSASMIKRYAEHHEDLEKLKEFIKAN- ^■KPELYHDIFKDETK 356

WP 049473442 278 LLGKIGDDYADLFTLAKNLYDAILLSGILTADDSSTKAPLSASMIQRYNEHQMDLAQLKQFIRQK-^■LSDKYNEVFSDVSK 356

WP ^"04947 4547 278 LLAQIGDNYAELFLSAKKLYDSILLSGILTVTDVSTKAPLSASMIQRYNEHQMDLTQLKQFIRQK- ^■LSDKYNEVFSDVSK 356

EMC03581 271 LLAQIGDNYAELFLSAKKLYDSILLSGILTVTDVSTKAPLSASMIQRYNEHQMDLAQLKQFIRQK- ^■LSDKYNEVFSDVSK 349

WP 00042 8612 279 LLGQIGDDFADLFVAAKKLYDAILLSGILTVTDPSTKAPLSASMIERYENHQKDLATLKQFIKTN- ^■LPEKYDEVFSDQSK 357

WP ^"00042 8613 279 LLGQIGDDFADLFLVAKKLYDAILLSGILTVTDPSTKAPLSASMIERYENHQKDLAVLKQFIKNN- ^■LPEKYDEVFSDQSK 357

WP ^"04952 3028 278 LLGQIGDVYADLFWAKKLYDAILLAGILSVKDPGTKAPLSASMIERYDNHQNDLSALKQFVRRN- ^■LPEKYAEVFSDDSK 356

WP ^"00310 7102 247 LLAQIGDQYADLFIAAKNLSDAILLSDILTVKG TKAPLSASMVQRFNEHQDDLKLLKKLVKVQ- ^■LPEKYKEIFDIKDK 325

WP ^"05427 9288 280 LLTQIGDEYADLFLSAKNLSDAILLSDILTVNGDGTQAPLSASLIKRYEEHRQDLALLKQMFKEQ- ^■LPDLYRDVFTDENK 358

WP ^"04953 1101 279 LLGQIGDDFADLFLVAKKLYDAILLSGILTVTDPSTKAPLSASMIERYENHQKDLAALKQFIKNN- ^■LPEKYDEVFSDQSK 357

WP ^"04953 8452 279 LLGQIGDGFADLFLVAKKLYDAILLSGILTVTDPSTKAPLSASMIERYQNHQNDLASLKQFIKNN- ^■LPEKYDEVFSDQSK 357

WP ^"04954 9711 279 LLGQIGDDFADLFLVAKKLYDAILLSGILTVTDPSTKAPLSASMIERYENHQKDLTTLKQFIKNN- ^■LPEKYDEVFSDQSK 357

WP ^"00789 6501 280 LLAEIGDHYADLFLAAKNLSDAILLSDILTLSDENTRAPLSASMIKRYEEHQEDLALLKKLVKEQ- ^■MPEKYWEI FSNAKK 358

EFR44625 232 LLAEIGDHYADLFLAAKNLSDAILLSDILTLSDENTRAPLSASMIKRYEEHQEDLALLKKLVKEQ- ^■MPEKYWEI FSNAKK 310

WP 00289 7477 278 LLGQIGDDFADLFLIAKKLYDAILLSGILTVTDPSTKAPLSASMIERYENHQKDLAALKQFIKNN- ^■LPEKYVEVFSDQSK 356

WP ^"00290 6454 278 LLGQIGDGFADLFLVAKKLYDAILLSGILTVTDPSTKAPLSASMIERYENHQEDLAALKQFIKNN- ^■LSEKYAEVFSDQSK 356

WP ^"00972 9476 279 LLGQIGDDFADLFLVAKKLYDAILLSGILTVTNPSTKAPLSASMIERYENHQKDLASLKQFIKNN- ^■LPEKYDEVFSDQSE 357

CQR24647 278 LLGIIGDEYADVFVAAKKVYDSILLSGILTTNNHSTKAPLSASMIDRYDEHNSDKKLLRDFIRTNi .GKEVFKEVFYDTSK 357

WP 00006 6813 279 LLGQIGDDFADLFLVAKKLYDAILLSGILTVKDLSTKAPLSASMIERYENHQKDLAALKQFIQNN- ^■LQEKYDEVFSDQSK 357

WP ^"00975 4323 279 LLGQIGDDFADLFLVAKKLYDAILLSGILTVTDPSTKAPLSASMIERYENHQEDLAALKQFIKNN- ^■LPEKYAEVFSDQSK 357

WP ^"04467 4937 278 LLGKIGDDYADLFIATKSLYDGILLAGILSTTDSTTKAPLSSSMVNRYEEHKKDLALLKNFIHQN- ^■LSDSYKEVFNDKLK 356

WP ^"04467 6715 278 LLGKIGDDYADLFIATKSLYDGILLAGILSTTDSTTKAPLSSSMVNRYEEHQKDLALLKNFIHQN- ^■LSDSYKEVFNDKLK 356

WP ^"04468 0361 278 LLGKIGDDYADLFIATKSLYDGILLAGILSTTDSTTKAPLSSSMVNRYEEHQKDLALLKNFIHQN- ^■LSDSYKEVFNDKLK 356

WP ^"04468 1799 278 LLGKIGDDYADLFIATKSLYDGILLAGILSTTDSTTKAPLSSSMVNRYEEHKKDLALLKNFIHQN- ^■LSDSYKEVFNDKLK 356

WP ^"04953 3112 278 LLGEIGDEYADLFASAKNLYDAILLSGILTVDDNSTKAPLSASMVKRYEEHQKDLKKLKDFIKVN- ^■APDQYNAI FKDKNK 356

WP ^"02909 0905 244 LADVLADEEYDLLLTAQKIYSAIILDESMDGYEYFA EAKKESYRKHQEELVLVKKMLKSNa LITNDERAKF EY 315

WP ^"00650 6696 284 VEKDLGE-YVEFVDALHNVYSWVELQTIMGATHTD-NASISEAMVSRYNKHHDDLKLLKDCIKNN- ^■VPNKYFDMFRNDSE 360

AIT42264 278 LLAQIGDQYADLFLAAKNLSDAILLSDILR TEITKAPLSASMIKRYDEHHQDLTLLKALVRQQ- ^■LPEKYKEIFFDQSK 356

WP 03444 0723 284 LLSNIDEGYRDVFLQAKNVYNAIELSKILKTDGKETKAPLSAQMVELYNQHREDLKKYKDYIKAY- ^■LPEKYGETFKDATK 362

AKQ21048 278 LLAQIGDQYADLFLAAKNLSDAILLSDILR TEITKAPLSASMIKRYDEHHQDLTLLKALVRQQ- ^■LPEKYKEIFFDQSK 356

WP 00463 6532 277 LLGMTDDVFLDVFMAAKNVYDAVEMSAIISTDTGNSKAVLSNQMINFYDEHKVDLAQLKQFFKTH- ^■LPDKYYECFSDPSK 355

WP ^"00236 4836 284 ILAKVGDEYSDVFLAAKNVYDAVELSTILADSDKKSHAKLSSSMIVRFTEHQEDLKKFKRFIREN- ^■CPDEYDNLFKNEQK 362

WP ^"01663 1044 235 ILAKVGDEYSDVFLAAKNVYDAVELSTILADSDKKSHAKLSSSMIVRFTEHQEDLKKFKRFIREN- ^■CPDEYDNLFKNEQK 313

EMS ^"75795 21 LLEKSGEEFRDVFLQAKKVYDAILLSDILSTKKQNSKAKLSLGMIERYDSHKKDLEELKQFVKAN- ^■LPEKTAIFFKDSSK 99

WP 00237 3311 284 ILAKVGDEYSDVFLAAKNVYDAVELSTILADSDKKSHAKLSSSMIVRFTEHQEDLKKFKRFIREN- ^■CPDEYDNLFKNEQK 362

WP ^"00237 8009 284 ILAKVGDEYSDVFLAAKNVYDAVELSTILADSDKKSHAKLSSSMIVRFTEHQEDLKNFKRFIREN- ^■CPDEYDNLFKNEQK 362

WP ^"00240 7324 284 ILAKVGDEYSDVFLAAKNVYDAVELSTILADSDKKSHAKLSSSMIVRFTEHQEDLKNFKRFIREN- ^■CPDEYDNLFKNEQK 362

WP ^"00241 3717 284 ILAKVGDEYSDVFLAAKNVYDAVELSTILADSDKKSHAKLSSSMIVRFTEHQEDLKKFKRFIREN- ^■CPDEYDNLFKNEQK 362

WP ^"01077 5580 286 ILAKVGDEYSDVFLAAKNVYDAVELSTILADSDKKSHAKLSSSMIVRFTEHQEDLKNFKRFIREN- ^■CPDEYDNLFKNEQK 364

WP ^"01081 8269 284 ILAKVGDEYSDVFLAAKNVYDAVELSTILADSDKKSHAKLSSSMIVRFTEHQEDLKKFKRFIREN- ^■CPDEYDNLFKNEQK 362

WP 010824395 284 ILAKVGDEYSDVFLAAKNVYDAVELSTILADSDKKSHAKLSSSMIVRFTEHQEDLKNFKRFIREN-CPDEYDNLFKNEQK 362

WP ^"016622645 284 ILAKVGDEYSDVFLAAKNVYDAVELSTILADSDKKSYAKLSSSMIVRFTEHQEDLKKFKRFIREN-CPDEYDNLFKNEQK 362

WP ^"033624816 284 ILAKVGDEYSDVFLAAKNVYDAVELSTILADSDKKSHAKLSSSMIVRFTEHQEDLKNFKRFIREN-CPDEYDNLFKNEQK 362

WP ^"033625576 284 ILAKVGDEYSDVFLAAKNVYDAVELSTILADSDKKSHAKLSSSMIVRFTEHQEDLKKFKRFIREN-CPDEYDNLFKNEQK 362

WP ^"033789179 284 ILAKVGDEYSDVFLAAKNVYDAVELSTILADSDKKSHAKLSSSMIVRFTEHQEDLKNFKRFIREN-CPDEYDNLFKNEQK 362

WP ^"002310644 282 LLEKIGDDYIDLFVQAKNVYDAVLLSEILSDSTKNTRAKLSAGMIRRYDAHKEDLVLLKRFVKEN-LPKKYRAFFGDNSV 360

WP ^"002312694 283 LLEKIGDDYIDLFVQAKNVYDAVLLSEILSDSTKNTRAKLSAGMIRRYDAHKEDLVLLKRFVKEN-LPKKYRAFFGDNSV 361

WP ^"002314015 283 LLEKIGDDYIDLFVQAKNVYDAVLLSEILSDSTKNTRAKLSAGMIRRYDAHKEDLVLLKRFVKEN-LPKKYRAFFGDNSV 361

WP ^"002320716 283 LLEKIGDDYIDLFVQAKNVYDAVLLSEILSDSTKNTRAKLSAGMIRRYDAHKEDLVLLKRFVKEN-LPKKYRAFFGDNSV 361

WP ^"002330729 282 LLEKIGDDYIDLFVQAKNVYDAVLLSEILSDSTKNTRAKLSAGMIRRYDAHKEDLVLLKRFVKEN-LPKKYRAFFGDNSV 360

WP ^"002335161 283 LLEKIGDDYIDLFVQAKNVYDAVLLSEILSDSTKNTRAKLSAGMIRRYDAHKEDLVLLKRFVKEN-LPKKYRAFFGDNSV 361

WP ^"002345439 283 LLEKIGDDYIDLFVQAKNVYDAVLLSEILSDSTKNTRAKLSAGMIRRYDAHKEDLVLLKRFVKEN-LPKKYRAFFGDNSV 361

WP ^"034867970 276 LLEKIGDEYLDIFLQAKKVHDAILLSEIISSTVKHTKAKLSSGMVERYERHKADLAKFKQFVKEN-VPQKATVFFKDTTK 354

WP ^"047937432 283 LLEKIGDDYIDLFVQAKNVYDAVLLSEILSDSTKNTRAKLSAGMIRRYDAHKEDLVLLKRFVKEN-LPKKYRAFFGDNSV 361

WP ^"010720994 276 LLEKIGDEYLDIFLQAKKVHDAILLSEIISSTVKHTQAKLSSGMVERYERHKADLAKFKQFVKEN-VPQKATVFFKDTTK 354

WP ^"010737004 276 LLEKIGDEYLDIFLQAKKVHDAILLSEIISSTVKHTKAKLSSGMVERYERHKADLAKFKQFVKEN-VPQKATVFFKDTTK 354

WP ^"034700478 276 LLEKIGDEYLDIFLQAKKVHDAILLSEIISSTVKHTQAKLSSGMVERYERHKADLAKFKQFVKEN-VPQKATVFFKDTTK 354

WP ^"007209003 281 LLAIIGDEYGDIFVAAQNLYQAILLAGILTSTEK-TRAKLSASMIQRYEEHAKDLKLLKRFVKEH IPDKYAEIFNDATK 358

WP ^"023519017 276 LLEKTSDDYAELFLKAKGVYDAILLSQILSKSDDETKAKLSANMKLRFEEHQRDLKQLKELVRRD LPKKYDDFFKNRSK 354

WP ^"010770040 279 LLAIIGDEYAEIFSATKSVYDAVALSGILSVTDGDTKAKLSASMVERYEAHQKDLVQFKQFIRKE LPEMYAPIFRDNSV 357

WP ^"048604708 275 LLGEIGDEYADVFEAAKNVYNAVELSGILTVTDNSTKAKLSASMIKRYEDHKTDLKLFKEFIRKN LPEKYHEI FNDKNT 353

WP ^"010750235 276 LLRKSNEEMIDVFLQVKKVYDAILLSDILSTKMKDTKAKLSAGMIERYQNHKKDLEELKQFVRAH-LHEKVTVFFKDSSK 354

AII16583 317 LLAQIGDQYADLFLAAKNLSDAILLSDILR TEITKAPLSASMIKRYDEHHQDLTLLKALVRQQ-LPEKYKEIFFDQSK 395

WP_029073316 290 KQPLLGD-CVEFIDLLHDIYSWVELQNILGSAHTS-EPSISAAMIQRYEDHKNDLKLLKDVIRKY-LPKKYFEVFRDEKS 366

WP_031589969 290 KQPLLGD-CVEFIDLLHDIYSWVELQNILGSAHTS-EPSISAAMIQRYEDHKNDLKLLKDVIRKY-LPKKYFEVFRDEKS 366

KDA45870 276 LLAEAGDQYLDIFVAAKKVYDAAILASILDVKDTQTKTVFSQAMIERYEEHQKDLIELKRVFKKY-LPEKCHDFFSE-PK 353

WP_039099354 286 LESSLDDNAHQIIESLQELYSGVLLAGIVPENQSLS QAMITKYDDHQKHLKMLKAVREAL-APEDRQRLKQAYDQ 359

AKP02966 279 LDSILDDDQFTVLDTANRIYSTITLNEIL NGESYFSMAK QYENHAIDLCKLRDMWHTT KNEKAV-GLSR 348

WP_010991369 284 LLALIGDEYAELFVAAKNAYSAWLSSIITVAETETNAKLSASMIERFDTHEEDLGELKAFIKLH-LPKHYEEIFSNTEK 362

WP_033838504 284 LLALIGDEYAELFVAAKNAYSAWLSSIITVAETETNAKLSASMIERFDTHEEDLGELKAFIKLH-LPKHYEEIFSNTEK 362

EHN60060 287 LLALIGDEYAELFVAAKNAYSAWLSSIITVAETETNAKLSASMIERFDTHEEDLGELKAFIKLH-LPKHYEEIFSNTEK 365

EFR89594 53 LLALIGDEYAELFVAAKNAYSAWLSSIITVAETETNAKLSASMIERFDTHEEDLGELKAFIKLH-LPKHYEEIFSNTEK 131

WP_038409211 LLAKIGDEYAEIFVAAKSTYNAWLSNIITVTDTETKAKLSASMIERFDKHAKDLKRLKAFFKMQ-LPEKFNEVFNDIEK 362 EFR95520

WP 003723650 2En LLAIIGDEYAELFVAAKNTYNAWLSSIITVTDTETNAKLSASMIERFDAHEKDLVELKAFIKLN-LPKQYEEIFSNAAI 362

WP ^"003727705 2Eu LLAIIGDEYAELFVAAKNTYNAWLSSIITVTATETNAKLSASMIERFDAHEKELGELKAFIKLH-LPKQYQEIFNNAEI 362

WP ^"003730785 2Eu LLAIIGDEYAELFVAAKNTYNAWLSSIITVTATETNAKLSASMIERFDAHEKELGELKAFIKLH-LPKQYQEIFNNAEI 362

WP ^"003733029 21 34 LLAIIGDEFAEVFVAAKNAYNAWLSNIITVTDSTTRAKLSASLIERFENHKEDLKKMKRFVRTY-LPEKYDEIFDDTEK 362

WP ^"003739838 2iu LLAIIGDEYAELFVAAKNTYNAWLSSIITVTDTETNAKLSASMIERFDAHEKDLSELKAFIKLH-LPKQYEEIFSNVAI 362

WP 014601172 284 LLAI IGDEYAELFVAAKNTYNAWLSSI ITVTATETNAKLSASMIERFDAHEKDLGELKAFIKLH- LPKQYQEI FNNAAI 362

WP 023548323 2 84 LLAI IGDEYAELFVAAKNTYNAWLSSI ITVTDTETNAKLSASMIERFDAHEKDLVELKAFIKLN- LPKQYEEI FSNAAI 362

WP 031665337 2 84 LLAI IGDEYAELFVAAKNTYNAWLSSI ITVNDTETNAKLSASMIERFDAHEKDLVELKAFIKLN- LPKQYEEI FSNAAI 362

WP 031669209 2 84 LLAI IGDEFAEVFVAAKNAYNAWLSNI ITVTDSTTRAKLSASLIERFENHKEDLKKMKRFVRTY- LPEKYDEIFDDTEK 362

WP 033920898 2 84 LLAI IGDEYAELFVAAKNTYNAWLSSI ITVTDTETNAKLSASMIERFDAHEKDLVELKAFIKLN- LPKQYEEI FSNAAI 362

AKI42028 2 87 LLAI IGDEYAELFVAAKNTYNAWLSSI ITVTATETNAKLSASMIERFDAHEKDLGELKAFIKLH- LPKQYQEI FNNAAI 365

AKI50529 2 87 LLAI IGDEYAELFVAAKNTYNAWLSSI ITVTDTETNAKLSASMIERFDAHEKDLVELKAFIKLN- LPKQYEEI FSNAAI 365

EFR83390

WP 046323366 2 84 LLARVGDEYAEIFVAAKNAYNAWLSSIITVSNTETKAKLSASMIERFDKHDKDLKRMKAFFKVR- LPENFNEVFNDVEK 362

AKE81011 2 94 LLAQIGDQYADLFLAAKNLSDAILLSDILRVNTEITKAPLSASMIKRYDEHHQDLTLLKALVRQQ- LPEKYKEIFFDQSK 372

CU082355 2 88 VENDLGE-YVEFIDSLHNIYSWVELQTIMGATHTD-NASISEAMVSRYNKHHEDLQLLKKCIKDN- VPKKYFDMFRNDSE 364

WP 033162887 2 89 LQSELGE-YIEFIEMLHNIYSWVELQAILGATHTD-NPSISAAMVERYEEHKKDLRVLKKVIREE- LPDKYNEVFRKDNR 365

AGZ 01981 3 11 LLAQIGDQYADLFLAAKNLSDAILLSDILRVNTEITKAPLSASMIKRYDEHHQDLTLLKALVRQQ- LPEKYKEIFFDQSK 389

AKA60242 2 78 LLAQIGDQYADLFLAAKNLSDAILLSDILRVNTEITKAPLSASMIKRYDEHHQDLTLLKALVRQQ- LPEKYKEIFFDQSK 356

AKS40380 2 78 LLAQIGDQYADLFLAAKNLSDAILLSDILRVNTEITKAPLSASMIKRYDEHHQDLTLLKALVRQQ- LPEKYKEIFFDQSK 356

4UN5 B 2 82 LLAQIGDQYADLFLAAKNLSDAILLSDILRVNTEITKAPLSASMIKRYDEHHQDLTLLKALVRQQ- LPEKYKEIFFDQSK 360

WP 010922251 357 --NGYAG YIDG G ASQEEFYKFIKPILEK--M--DGTEELLv--KLNREDLLRKQRTFDNG|S|IPHQIHLGEL 419

WP 039695303 358 - -NGYAG YIEN G VKQDEFYKYLKNILSK- -IkiDGSDYFL— DKIEREDFLRKQRTFDNGSIPHQIHLQEM 422

WP ^"045635197 357 - -DGYAG YIDG K TTQETFYKYIKNLLSK- -F- -EGTDYFL— DKIEREDFLRKQRTFDNGSIPHQIHLQEM 419

5AXW A 169 c SINR 1 oQ PJJiViAV7^"V Έ¹ Δ 183

WP 009880683 41 - -NGYAG YIDG G ASQEEFYKFIKPILEK- -M- -DGTEELLa- -KLNREDLLRKQRTFDNGSIPHQIHLGEL 103

WP ^"010922251 357 - -NGYAG YIDG G ASQEEFYKFIKPILEK- -M- -DGTEELLv- -KLNREDLLRKQRTFDNGSIPHQIHLGEL 419

WP ^"011054416 357 - -NGYAG YIDG G ASQEEFYKFIKPILEK- -M- -DGTEELLa- -KLNREDLLRKQRTFDNGSIPYQIHLGEL 419

WP ^"011284745 357 - -NGYAG YIDG G ASQEEFYKFIKPILEK- -M- -DGTEELLa- -KLNREDLLRKQRTFDNGSIPHQIHLGEL 419

WP ^"011285506 357 - -NGYAG YIDG G ASQEEFYKFIKPILEK- -M- -DGTEELLv- -KLNREDLLRKQRTFDNGSIPHQIHLGEL 419

WP ^"011527619 357 - -NGYAG YIDG G ASQEEFYKFIKPILEK- -M- -DGTEELLa- -KLNREDLLRKQRTFDNGSIPHQIHLGEL 419

WP ^"012560673 357 - -NGYAG YIDG G ASQEEFYKFIKPILEK- -M- -DGTEELLa- -KLNREDLLRKQRTFDNGSIPHQIHLGEL 419

WP ^"014407541 357 - -NGYAG YIDG G ASQEEFYKFIKPILEK- -M- -DGTEELLv- -KLNREDLLRKQRTFDNGSIPHQIHLGEL 419

WP ^"020905136 357 - -NGYAG YIDG G ASQEEFYKFIKPILEK- -M- -DGTEELLa- -KLNREDLLRKQRTFDNGSIPHQIHLGEL 419

WP ^"023080005 357 - -NGYAG YIDG G ASQEEFYKFIKPILEK- -M- -DGTEELLa- -KLNREDLLRKQRTFDNGSIPYQIHLGEL 419

WP ^"023610282 357 - -NGYAG YIDG G ASQEEFYKFIKPILEK- -M- -DGTEELLa- -KLNREDLLRKQRTFDNGSIPYQIHLGEL 419

WP ^"030125963 357 - -NGYAG YIDG G ASQEEFYKFIKPILEK- -M- -DGTEELLv- -KLNREDLLRKQRTFDNGSIPHQIHLGEL 419

WP ^"030126706 357 - -NGYAG YIDG G ASQEEFYKFIKPILEK- -M- -DGTEELLa- -KLNREDLLRKQRTFDNGSIPYQIHLGEL 419

WP ^"031488318 357 - -NGYAG YIDG G ASQEEFYKFIKPILEK- -M- -DGTEELLa- -KLNREDLLRKQRTFDNGSIPHQIHLGEL 419

WP ^"032460140 357 - -NGYAG YIDG G ASQEEFYKFIKPILEK- -M- -DGTEELLa- -KLNREDLLRKQRTFDNGSIPHQIHLGEL 419

WP ^"032461047 357 - -NGYAG YIDG G ASQEEFYKFIKPILEK- -M- -DGTEELLa- -KLNREDLLRKQRTFDNGSIPHQIHLGEL 419

WP ^"032462016 357 - -NGYAG YIDG G ASQEEFYKFIKPILEK- -M- -DGTEELLv- -KLNREDLLRKQRTFDNGSIPHQIHLGEL 419

WP ^"032462936 357 - -NGYAG YIDG G ASQEEFYKFIKPILEK- -M- -DGTEELLa- -KLNREDLLRKQRTFDNGSIPHQIHLGEL 419

WP ^"032464890 357 - -NGYAG YIDG G ASQEEFYKFIKPILEK- -M- -DGTEELLa- -KLNRKDLLRKQRTFDNGSIPHQIHLGEL 419

WP ^"033888930 182 - -NGYAG YIDG G ASQEEFYKFIKPILEK- -M- -DGTEELLv- -KLNREDLLRKQRTFDNGSIPHQIHLGEL 244

WP ^"038431314 357 - -NGYAG YIDG G ASQEEFYKFIKPILEK- -M- -DGTEELLa- -KLNREDLLRKQRTFDNGSIPHQIHLGEL 419

WP ^"038432938 357 - -NGYAG YIDG G ASQEEFYKFIKPILEK- -M- -DGTEELLa- -KLNREDLLRKQRTFDNGSIPYQIHLGEL 419

WP ^"038434062 357 - -NGYAG YIDG G ASQEEFYKFIKPILEK- -M- -DGTEELLa- -KLNREDLLRKQRTFDNGSIPHQIHLGEL 419

BAQ51233 268 - -NGYAG YIDG G ASQEEFYKFIKPILEK- -M- -DGTEELLv- -KLNREDLLRKQRTFDNGSIPHQIHLGEL 330

KGE60162

KGE60856

WP 002989955 357 - -NGYAG YIDG G ASQEEFYKFIKPILEK- -M- -DGTEELLa- -KLNREDLLRKQRTFDNGSIPHQIHLGEL 419

WP ^"003030002 357 - -KGYAG YIEN G VKQDEFYKYLKGILLQ- -I- -NGSGDFL— DKIDREDFLRKQRTFDNGSIPHQIHLQEM 419

WP ^"003065552 360 - -NGYAG YIEN G VKQDEFYKYLKNTLSK- -Ia —GSDYFL— DKIEREDFLRKQRTFDNGSIPHQIHLQEM 422

WP ^"001040076 358 - -DGYAG YIEG K TNQEAFYKYLSKLLTK- -Q- -EGSEYFL— EKIKNEDFLRKQRTFDNGSIPHQVHLTEL 420

WP ^"001040078 358 - -DGYAG YIEG K TNQEAFYKYLSKLLTK- -Q- -EDSENFL— EKIKNEDFLRKQRTFDNGSIPHQVHLTEL 420

WP ^"001040080 358 - -DGYAG YIEG K TNQEAFYKYLSKLLTK- -Q- -EDSENFL— EKIKNEDFLRKQRTFDNGSIPHQVHLTEL 420

WP ^"001040081 358 - -DGYAG YIEG K TNQEAFYKYLSKLLTK- -Q- -EDSENFL— EKIKNEDFLRKQRTFDNGSIPHQVHLTEL 420

WP ^"001040083 358 - -DGYAG YIEG K TNQEAFYKYLSKLLTK- -Q- -EDSENFL— EKIKNEDFLRKQRTFDNGSIPHQVHLTEL 420

WP ^"001040085 358 - -DGYAG YIEG K TNQEAFYKYLSKLLTK- -Q- -EDSENFL— EKIKNEDFLRKQRTFDNGSIPHQVHLTEL 420

WP 001040087 358 —DGYAG YIEG K TNQEAFYKYLSKLLTK-^■Q--EDSENFL--EKIKNEDFLRKQRTFDNGSIPHQVHLTEL 420

WP 001040088 358 —DGYAG YIEG K TNQEAFYKYLSKLLTK- ^■Q- -EDSENFL- -EKIKNEDFLRKQRTFDNGSIPHQVHLTEL 420

WP 001040089 358 —DGYAG YIEG K TNQEAFYKYLSKLLTK- ^■Q- -EDSENFL- -EKIKNEDFLRKQRTFDNGSIPHQVHLTEL 420

WP 001040090 358 —DGYAG YIEG K TNQEAFYKYLSKLLTK- ^■Q- -EDSENFL- -EKIKNEDFLRKQRTFDNGSIPHQVHLTEL 420

WP 001040091 358 —DGYAG YIEG K TNQEAFYKYLSKLLTK- ^■Q- -EDSENFL- -EKIKNEDFLRKQRTFDNGSIPHQVHLTEL 420

WP 001040092 358 —DGYAG YIEG K TNQEAFYKYLSKLLTK- ^■Q- -EDSEYFL- -EKIKNEDFLRKQRTFDNGSIPHQVHLTEL 420

WP 001040094 358 —DGYAG YIEG K TNQEAFYKYLSKLLTK- ^■Q- -EGSEYLL- -EKIKNEDFLRKQRTFDNGSIPHQVHLTEL 420

WP 001040095 358 —DGYAG YIEG K TNQEAFYKYLSKLLTK- ^■Q- -EGSEYLL- -EKIKNEDFLRKQRTFDNGSIPHQVHLTEL 420

WP 001040096 358 —DGYAG YIEG K TNQEAFYKYLSKLLTK- ^■Q- -EGSEYLL- -EKIKNEDFLRKQRTFDNGSIPHQVHLTEL 420

WP 001040097 358 —DGYAG YIEG K TNQEAFYKYLSKLLTK- ^■Q- -EGSEYLL- -EKIKNEDFLRKQRTFDNGSIPHQVHLTEL 420

WP 001040098 358 —DGYAG YIEG K TNQEAFYKYLSKLLTK- ^■Q- -EGSEYLL- -EKIKNEDFLRKQRTFDNGSIPHQVHLTEL 420

WP 001040099 358 —DGYAG YIEG K TNQEAFYKYLSKLLTK- ^■Q- -EGSEYLL- -EKIKNEDFLRKQRTFDNGSIPHQVHLTEL 420

WP 001040100 358 —DGYAG YIEG K TNQEAFYKYLSKLLTK- ^■Q- -EGSEYLL- -EKIKNEDFLRKQRTFDNGSIPHQVHLTEL 420

WP 001040104 358 —DGYAG YIEG K TNQEAFYKYLSKLLTK- ^■Q- -EDSENFL- -EKIKNEDFLRKQRTFDNGSIPHQVHLTEL 420

WP 001040105 358 —DGYAG YIEG K TNQEAFYKYLSKLLTK- ^■Q- -EDSENFL- -EKIKNEDFLRKQRTFDNGSIPHQVHLTEL 420

WP 001040106 358 —DGYAG YIEG K TNQGAFYKYLSKLLTK- ^■Q- -EGSEYFL- -EKIKNEDFLRKQRTFDNGSIPHQVHLTEL 420

WP 001040107 358 —DGYAG YIEG K TNQGAFYKYLSKLLTK- ^■Q- -EGSEYFL- -EKIKNEDFLRKQRTFDNGSIPHQVHLTEL 420

WP 001040108 358 —DGYAG YIEG K TNQGAFYKYLSKLLTK- ^■Q- -EGSEYFL- -EKIKNEDFLRKQRTFDNGSIPHQVHLTEL 420

WP 001040109 358 —DGYAG YIEG K TNQGAFYKYLSKLLTK- ^■Q- -EGSEYFL- -EKIKNEDFLRKQRTFDNGSIPHQVHLTEL 420

WP 001040110 358 —DGYAG YIEG K TNQGAFYKYLSKLLTK- ^■Q- -EGSEYFL- -EKIKNEDFLRKQRTFDNGSIPHQVHLTEL 420

WP 015058523 358 —DGYAG YIEG K TNQEAFYKYLSKLLTK- ^■Q- -EDSEYFL- -EKIKNEDFLRKQRTFDNGSIPHQVHLTEL 420

WP 017643650 358 —DGYAG YIEG K TNQEAFYKYLSKLLTK- ^■Q- -EGSEYLL- -EKIKNEDFLRKQRTFDNGSIPHQVHLTEL 420

WP 017647151 358 —DGYAG YIEG K TNQGAFYKYLSKLLTK- ^■Q- -EGSEYFL- -EKIKNEDFLRKQRTFDNGSIPHQVHLTEL 420

WP 017648376 358 —DGYAG YIEG K TNQGAFYKYLSKLLTK- ^■Q- -EGSEYFL- -EKIKNEDFLRKQRTFDNGSIPHQVHLTEL 420

WP 017649527 358 —DGYAG YIEG K TNQEAFYKYLSKLLTK- ^■Q- -EDSENFL- -EKIKNEDFLRKQRTFDNGSIPHQVHLTEL 420

WP 017771611 358 —DGYAG YIEG K TNQGAFYKYLSKLLTK- ^■Q- -EGSEYFL- -EKIKNEDFLRKQRTFDNGSIPHQVHLTEL 420

WP 017771984 358 —DGYAG YIEG K TNQEAFYKYLSKLLTK- ^■Q- -EDSENFL- -EKIKNEDFLRKQRTFDNGSIPHQVHLTEL 420

CFQ25032 358 —DGYAG YIEG K TNQEAFYKYLSKLLTK- ^■Q- -EDSENFL- -EKIKNEDFLRKQRTFDNGSIPHQVHLTEL 420

CFV16040 358 —DGYAG YIEG K TNQEAFYKYLSKLLTK- ^■Q- -EDSENFL- -EKIKNEDFLRKQRTFDNGSIPHQVHLTEL 420

KLJ37842 358 —DGYAG YIEG K TNQEAFYKYLSKLLTK- ^■Q- -EDSENFL- -EKIKNEDFLRKQRTFDNGSIPHQVHLTEL 420

KLJ72361 358 —DGYAG YIEG K TNQEAFYKYLSKLLTK- ^■Q- -EDSENFL- -EKIKNEDFLRKQRTFDNGSIPHQVHLTEL 420

KLL20707 358 —DGYAG YIEG K TNQEAFYKYLSKLLTK- ^■Q- -EDSENFL- -EKIKNEDFLRKQRTFDNGSIPHQVHLTEL 420

KLL42645 358 —DGYAG YIEG K TNQGAFYKYLSKLLTK- ^■Q- -EGSEYFL- -EKIKNEDFLRKQRTFDNGSIPHQVHLTEL 420

WP 047207273 358 —DGYAG YIEG K TNQEAFYKYLSKLLTK- ^■Q- -EDSENFL- -EKIKNEDFLRKQRTFDNGSIPHQVHLTEL 420

WP 047209694 358 —DGYAG YIEG K TNQEAFYKYLSKLLTK- ^■Q- -EGSEYLL- -EKIKNEDFLRKQRTFDNGSIPHQVHLTEL 420

WP 050198062 358 —DGYAG YIEG K TNQEAFYKYLSKLLTK- ^■Q- -EDSENFL- -EKIKNEDFLRKQRTFDNGSIPHQVHLTEL 420

WP 050201642 358 —DGYAG YIEG K TNQEAFYKYLSKLLTK- ^■Q- -EDSENFL- -EKIKNEDFLRKQRTFDNGSIPHQVHLTEL 420

WP 050204027 358 —DGYAG YIES K TNQGAFYKYLSKLLTK- ^■Q- -EGSEYFL- -EKIKNEDFLRKQRTFDNGSIPHQVHLTEL 420

WP 050881965 358 —DGYAG YIEG K TNQEAFYKYLSKLLTK- ^■Q- -EDSENFL- -EKIKNEDFLRKQRTFDNGSIPHQVHLTEL 420

WP 050886065 358 --DGYAG YIEG K TNQEAFYKYLSKLLTK-^■Q--EDSENFL--EKIKNEDFLRKQRTFDNGSIPHQVHLTEL 420

AHN30376 358 - -DGYAG YIEG K TNQEAFYKYLSKLLTK- ^■Q- -EDSEYFL- -EKIKNEDFLRKQRTFDNGSIPHQVHLTEL 420

EA078426 358 - -DGYAG YIEG K TNQEAFYKYLSKLLTK- ^■Q- -EDSENFL- -EKIKNEDFLRKQRTFDNGSIPHQVHLTEL 420

CCW42055 358 - -DGYAG YIEG K TNQEAFYKYLSKLLTK- ^■Q- -EGSEYLL- -EKIKNEDFLRKQRTFDNGSIPHQVHLTEL 420

WP 003041502 357 - -KGYAG YIES G VKQDEFYKYLKGILLQ- ^■I- -NGSGDFL- -DKIDREDFLRKQRTFDNGSIPHQIHLQEM 419

WP 037593752 358 - -KGYAG YIES G VEQDEFYKYLKGILLK- ^■I- -NGSGDFL- -DKIDCEDFLRKQRTFDNGSIPHQIHLQEM 420

WP 049516684 358 - -NGYAG YIEN G VKQDEFYKYLKNTLSK- ^■I- -DGSDYFL- -DKIDREDFLRKQRTFDNGSIPHQIHLQEM 420

GAD46167 357 - -KGYAG YIES G VEQDEFYKYLKGILLK- ^■I- -NGSGDFL- -DKIDCEDFLRKQRTFDNGSIPHQIHLQEM 419

WP 018363470 358 - -NGYAG YIEN G VKQDEFYKYLKGILTK- ^■I- -NGSDYFL- -DKIEREDFLRKQRTFDNGSIPHQIHLQEM 420

WP 003043819 357 - -NGYAG YVGI G ATQEEFYKFIKPILEK- ^■M- -DGAEELLa —KLNRDDLLRKQRTFDNGSIPHQIHLKEL 429

WP 006269658 357 - -KGYAS YIES G VKQDEFYKYLKGILLK- ^■I- -NGSGDFL- -DKIDREDFLRKQRTFDNGSIPHQIHLQEM 419

WP 048800889 357 - -NGYAG YIEN G VKQDEFYKYLKNTLSK- ^■I- -DGSGYFL- -DKIEREDFLRKQRTFDNGSIPHQIHLQEM 419

WP 012767106 357 - -NGYAG YIDG G ASQEEFYKFIKPILEK- ^■M- -DGTEELLa —KLNREDLLRKQRTFDNGSIPHQIHLGEL 419

WP 014612333 357 - -NGYAG YIDG G ASQEEFYKFIKPILEK- ^■M- -DGTEELLa —KLNREDLLRKQRTFDNGSIPHQIHLGEL 419

WP 015017095 357 - -NGYAG YIDG G ASQEEFYKFIKPILEK- ^■M- -DGTEELLa —KLNREDLLRKQRTFDNGSIPHQIHLGEL 419

WP 015057649 357 - -NGYAG YIDG G ASQEEFYKFIKPILEK- ^■M- -DGTEELLa —KLNREDLLRKQRTFDNGSIPHQIHLGEL 419

WP 048327215 357 - -NGYAG YIDG G ASQEEFYKFIKPILEK- ^■M- -DGTEELLa —KLNREDLLRKQRTFDNGSIPHQIHLGEL 419

WP 049519324 357 - -NGYAG YIDG G ASQEEFYKFIKPILEK- ^■M- -DGTEELLa —KLNREDLLRKQRTFDNGSIPHQIHLGEL 419

WP 012515931 357 - -NGYAG YIEG Q VSQEEFYKYLKPILAR- ^■L- -DGSEPLL1 —KIDREDFLRKQRTFDNGSIPHQIHLEEL 419

WP 021320964 357 - -NGYAG YIEG Q VSQEEFYKYLKPILAR- ^■L- -DGSEPLL1 —KIDREDFLRKQRTFDNGSIPHQIHLEEL 419

WP 037581760 357 - -NGYAG YIEG Q VSQEEFYKYLKPILAR- ^■L- -DGSEPLL1 —KIDREDFLRKQRTFDNGSIPHQIHLEEL 419

WP 004232481 357 - -NGYAG YIEN G VKQDI FYKHLKSI I SE- ^■K- -NGGQYFL- -DKIEREDFLRKQRTFDNGSIPYQIHLQEM 419

WP 009854540 358 - -NGYAG YIEN G VKQDEFYKYLKNTLSK- ^■I- -DGSDYFL- -DKIEREDFLRKQRTFDNGSIPHQIHLQEM 420

WP 012962174 358 - -NGYAG YIEN G VKQDEFYKYLKTTLSK- ^■I- -DGSDYFL- -DKIEREDFLRKQRTFDNGSIPHQIHLQEM 420

WP 039695303 358 - -NGYAG YIEN G VKQDEFYKYLKNILSK- ^■IkiDGSDYFL- -DKIEREDFLRKQRTFDNGSIPHQIHLQEM 422

WP 014334983 357 - -NGYAG YIDN G VKQDEFYKYLKTILTK- ^■I- -DDSDYFL- -DKIERDDFLRKQRTFDNGSIPHQIHLQEM 419

WP 003099269 357 - -NGYAG YIDG K TSQEEFYKYIKPILLK- ^■L- -DGTEKLIs —KLEREDFLRKQRTFDNGSIPHQIHLNEL 419

AHY15608 357 - -NGYAG YIDG K TSQEEFYKYIKPILLK- ^■L- -DGTEKLIs —KLEREDFLRKQRTFDNGSIPHQIHLNEL 419

AHY17476 357 - -NGYAG YIDG K TSQEEFYKYIKPILLK- ^■L- -DGTEKLIs —KLEREDFLRKQRTFDNGSIPHQIHLNEL 419

ESR09100

AGM98575 357 - -NGYAG YIDG K TSQEEFYKYIKPILLK- ^■L- -DGTEKLIs —KLEREDFLRKQRTFDNGSIPHQIHLNEL 419

ALF27331 357 - -DGYAG YIDG K TNQEAFYKYLKGLLNK- ^■I- -EGSGYFL- -DKIEREDFLRKQRTFDNGSIPHQIHLQEM 419

WP 018372492 355 - -PSYAA YVSG A VTEDDFYKFSKGLLID- ^■V- -EGAEYFL- -EKIEREDFLRKQRTFDNGAIPNQVHVKEL 432

WP 045618028 358 - -DGYAG YIDG K TTQEAFYKYIKNLLSK- ^■L- -EGADYFL- -DKIEREDFLRKQRTFDNGSIPHQIHLQEM 420

WP 045635197 357 - -DGYAG YIDG K TTQETFYKYIKNLLSK- ^■F- -EGTDYFL- -DKIEREDFLRKQRTFDNGSIPHQIHLQEM 419

WP 002263549 357 - -DGYAG YIDG K TNQEAFYKYLKGLLNK- ^■I- -EGSGYFL- -DKIEREDFLRKQRTFDNGSIPHQIHLQEM 419

WP 002263887 357 - -DGYAG YIDG K TNQEAFYKYLKGLLNK- ^■I- -EGSGYFL- -DKIEREDFLRKQRTFDNGSIPHQIHLQEM 419

WP 002264920 357 - -NGYAG YIEN G VKQDEFYKYLKNTLSK- ^■I- -AGSDYFL- -DKIEREDFLRKQRTFDNGSIPHQIHLQEM 419

WP 002269043 357 - -DGYAG YIDG K TNQEAFYKYLKGLLNK- ^■I- -EGSGYFL- -DKIEREDFLRKQRTFDNGSIPHQIHLQEM 419

WP 002269448 357 --DGYAG YIDG K TNQEAFYKYLKGLLNK-^■I EGSGYFL—DKIEREDFLRKQRTFDNGSI PHQIHLQEM 419

WP ^"002271977 357 - -DGYAG YIDG K TNQEAFYKYLKGLLNK- ^■I EGSGYFL—DKIEREDFLRKQRTFDNGSI PHQIHLQEM 419

WP ^"002272766 357 - -DGYAG YIDG K TNQEAFYKYLKGLLNK- ^■I EGSGYFL—DKIEREDFLRKQRTFDNGSI PHQIHLQEM 419

WP ^"002273241 357 - -DGYAG YIDG K TNQEAFYKYLKGLLNK- ^■I EGSGYFL—DKIEREDFLRKQRTFDNGSI PHQIHLQEM 419

WP ^"002275430 357 - -DGYAG YIDG K TNQEAFYKYLKGLLNK- ^■I EGSGYFL—DKIEREDFLRKQRTFDNGSI PHQIHLQEM 419

WP ^"002276448 357 - -DGYAG YIDG K TNQEAFYKYLKGLLNK- ^■I EGSGYFL—DKIEREDFLRKQRTFDNGSI PHQIHLQEM 419

WP ^"002277050 357 - -NGYAG YIEN G VKQDEFYKYLKNTLSK- ^■I -AGSDYFL—DKIEREDFLRKQRTFDNGSI PHQIHLQEM 419

WP ^"002277364 357 - -DGYAG YIDG K TNQEAFYKYLKGLLNK- ^■I EGSGYFL—DKIEREDFLRKQRTFDNGSI PHQIHLQEM 419

WP ^"002279025 357 - -DGYAG YIDG K TNQEAFYKYLKGLLNK- ^■I EGSGYFL—DKIEREDFLRKQRTFDNGSI PHQIHLQEM 419

WP ^"002279859 357 - -DGYAG YIDG K TNQEAFYKYLKGLLNK- ^■I EGSGYFL—DKIEREDFLRKQRTFDNGSI PHQIHLQEM 419

WP ^"002280230 357 - -DGYAG YIDG K TNQEAFYKYLKGLLNK- ^■I EGSGYFL—DKIEREDFLRKQRTFDNGSI PHQIHLQEM 419

WP ^"002281696 357 - -DGYAG YIDG K TNQEAFYKYLKGLLNK- ^■I EGSGYFL—DKIEREDFLRKQRTFDNGSI PHQIHLQEM 419

WP ^"002282247 357 - -NGYAG YIEN G VKQDEFYKYLKNTLSK- ^■I TGSDYFL—DQIEREDFLRKQRTFDNGSI PHQIHLQEM 419

WP ^"002282906 357 - -DGYAG YIDG K TNQEAFYKYLKGLLNK- ^■I EGSGYFL—DKIEREDFLRKQRTFDNGSI PHQIHLQEM 419

WP ^"002283846 357 - -DGYAG YIDG K TNQEAFYKYLKGLLNK- ^■I EGSGYFL—DKIEREDFLRKQRTFDNGSI PHQIHLQEM 419

WP ^"002287255 357 - -DGYAG YIDG K TNQEAFYKYLKGLLNK- ^■I EGSGYFL—DKIEREDFLRKQRTFDNGSI PHQIHLQEM 419

WP ^"002288990 357 - -DGYAG YIDG K TNQEAFYKYLKGLLNK- ^■I EGSGYFL—DKIEREDFLRKQRTFDNGSI PHQIHLQEM 419

WP ^"002289641 357 - -DGYAG YIDG K TNQEAFYKYLKGLLNK- ^■I EGSGYFL—DKIEREDFLRKQRTFDNGSI PHQIHLQEM 419

WP ^"002290427 357 - -DGYAG YIDG K TNQEAFYKYLKGLLNK- ^■I EGSGYFL—DKIEREDFLRKQRTFDNGSI PHQIHLQEM 419

WP ^"002295753 357 - -DGYAG YIDG K TNQEAFYKYLKGLLNK- ^■I EGSGYFL—DKIEREDFLRKQRTFDNGSI PHQIHLQEM 419

WP ^"002296423 357 - -DGYAG YIDG K TNQEAFYKYLKGLLNK- ^■I EGSGYFL—DKIEREDFLRKQRTFDNGSI PHQIHLQEM 419

WP ^"002304487 357 - -NGYAG YVGA D ATEEEFYKYVKGILNK- ^■V EGADVWL—DKIDREDFLRKQRTFDNGSI PHQIHLQEM 429

WP ^"002305844 357 - -DGYAG YIDG K TNQEAFYKYLKGLLNK- ^■I EGSGYFL—DKIEREDFLRKQRTFDNGSI PHQIHLQEM 419

WP ^"002307203 357 - -DGYAG YIDG K TNQEAFYKYLKGLLNK- ^■I EGSGYFL—DKIEREDFLRKQRTFDNGSI PHQIHLQEM 419

WP ^"002310390 357 - -DGYAG YIDG K TNQEAFYKYLKGLLNK- ^■I EGSGYFL—DKIEREDFLRKQRTFDNGSI PHQIHLQEM 419

WP ^"002352408 357 - -DGYAG YIDG K TNQEAFYKYLKGLLNK- ^■I EGSGYFL—DKIEREDFLRKQRTFDNGSI PHQIHLQEM 419

WP ^"012997688 357 - -DGYAG YIDG K TNQEAFYKYLKGLLNK- ^■I EGSGYFL—DKIEREDFLRKQRTFDNGSI PHQIHLQEM 419

WP ^"014677909 357 - -DGYAG YIDG K TNQEAFYKYLKGLLNK- ^■I EGSGYFL—DKIEREDFLRKQRTFDNGSI PHQIHLQEM 419

WP ^"019312892 357 - -DGYAG YIDG K TNQEAFYKYLKGLLNK- ^■I EGSGYFL—DKIEREDFLRKQRTFDNGSI PHQIHLQEM 419

WP ^"019313659 357 - -DGYAG YIDG K TNQEAFYKYLKGLLNK- ^■I EGSGYFL—DKIEREDFLRKQRTFDNGSI PHQIHLQEM 419

WP ^"019314093 357 - -DGYAG YIDG K TNQEAFYKYLKGLLNK- ^■I EGSGYFL—DKIEREDFLRKQRTFDNGSI PHQIHLQEM 419

WP ^"019315370 357 - -DGYAG YIDG K TNQEAFYKYLKGLLNK- ^■I EGNGYFL—DKIEREDFLRKQRTFDNGSI PHQIHLQEM 419

WP ^"019803776 357 - -DGYAG YIDG K TNQEAFYKYLKGLLNK- ^■I EGSGYFL—DKIEREDFLRKQRTFDNGSI PHQIHLQEM 419

WP ^"019805234 357 - -DGYAG YIDG K TNQEAFYKYLKGLLNK- ^■I EGSGYFL—DKIEREDFLRKQRTFDNGSI PHQIHLQEM 419

WP ^"024783594 357 - -DGYAG YIDG K TNQEAFYKYLKGLLNK- ^■I EGSGYFL—DKIEREDFLRKQRTFDNGSI PHQIHLQEM 419

WP ^"024784288 357 - -NGYAG YIEN G VKQDEFYKYLKNTLSK- ^■I TGSDYFL—DQIEREDFLRKQRTFDNGSI PHQIHLQEM 419

WP ^"024784666 357 - -DGYAG YIDG K TNQEAFYKYLKGLLNK- ^■I EGSGYFL—DKIEREDFLRKQRTFDNGSI PHQIHLQEM 419

WP ^"024784894 357 - -DGYAG YIDG K TNQEAFYKYLKGLLNK- ^■I EGSGYFL—DKIEREDFLRKQRTFDNGSI PHQIHLQEM 419

WP ^"024786433 357 - -NGYAG YIEN G VKQDEFYKYLKNTLSK- ^■I -AGSDYFL—DKIEREDFLRKQRTFDNGSI PHQIHLQEM 419

WP 049473442 357 --DGYAG YIDG K TNQEAFYKYLKGLLNK-^■I--EGSGYFL--DKIEREDFLRKQRTFDNGSIPHQIHLQEM 419

WP 049474547 357 - -DGYAG YIDG K TNQEAFYKYLKGLLNK- ^■I- -EGSGYFL- -DKIEREDFLRKQRTFDNGSIPHQIHLQEM 419

EMC03581 350 - -DGYAG YIDG K TNQEAFYKYLKGLLNK- ^■I- -EGSGYFL- -DKIEREDFLRKQRTFDNGSIPHQIHLQEM 412

WP 000428612 358 - -DGYAG YIDG K TTQESFYKYIKNLLSK- ^■F- -EGADYFL- -EKIEREDFLRKQRTFDNGSIPHQIHLQEM 420

WP 000428613 358 - -DGYAG YIDG K TTQEAFYKYIKNLLSK- ^■F- -EGTDYFL- -EKIEREDFLRKQRTFDNGSIPHQIHLQEM 420

WP 049523028 357 - -DGYAG YIDG K TTQEGFYKYIKNLISK- ^■I- -EGAEYFL- -EKIEREDFLRKQRTFDNGSIPHQIHLQEM 419

WP 003107102 326 - -NGYAG YING K TSQEDFYKYIKPILSK- ^■L- -KGAESLIs —KLEREDFLRKQRTFDNGSIPHQIHLNEL 388

WP 054279288 359 - -DGYAG YISG K TSQEAFYKYIKPILET- ^■L- -DGAEDFLt —KINREDFLRKQRTFDNGSIPHQIHLGEL 421

WP 049531101 358 - -EGYAG YIDS K TTQEAFYKYIKNLLSK- ^■I- -DGADYLL- -DKIEREDFLRKQRTFDNGSIPHQIHLQEM 420

WP 049538452 358 - -DGYAG YVDG K TTQEAFYKYIKNLLSK- ^■F- -EGADYFL- -EKIEREDFLRKQRTFDNGSIPHQIHLQEM 420

WP 049549711 358 - -DGYAG YIDG K TTQEAFYKYIKNLLSK- ^■F- -EGTDYFL- -EKIEREDFLRKQRTFDNGSIPHQIHLQEM 420

WP 007896501 359 - -NGYAG YIEG K VSQEDFYRYIKPILSR- ^■L- -KGGDEFLa —KIDRDDFLRKQRTFDNGSIPHQIHLKEL 421

EFR44625 311 - -NGYAG YIEG K VSQEDFYRYIKPILSR- ^■L- -KGGDEFLa —KIDRDDFLRKQRTFDNGSIPHQIHLKEL 373

WP 002897477 357 - -DGYAG YIDG K TTQEAFYKYIKNLLSK- ^■F- -EGADYFL- -DKIEREDFLRKQRTFDNGSIPHQIHLQEM 419

WP 002906454 357 - -DGYAG FIDG K TTQEAFYKYIKNLLSK- ^■L- -EGADYFL- -NKIEREDFLRKQRTFDNGSIPHQIHLQEM 419

WP 009729476 358 - -DGYAG YIDG K TTQETFYKYIKNLLSK- ^■F- -EGADYFL- -DKIEREDFLRKQRTFDNGSIPHQIHLQEM 420

CQR24647 358 - -NGYAG YIDG K TNQEDFYKYLKNLLQK- ^■V- -DGGDYFI- -EKIEREDFLRKQRTFDNGSIPHQVHLDEM 420

WP 000066813 358 - -DGYAG YIDG K TTQEAFYKYIKNLLSK- ^■F- -EGADYFL- -DKIEREDFLKKQRTFDNGSIPHQIHLQEM 420

WP 009754323 358 - -DGYAG YIDG K TTQEAFYKYIKNLLSK- ^■F- -EGADYFL- -DKIEREDFLRKQRTFDNGSIPHQIHLQEM 420

WP 044674937 357 - -DGYAG YIEG K TTQENFYRFIKKAIEK- ^■I- -EGSDYFI- -DKIDREDFLRKQRTFDNGSIPHQIHLQEM 419

WP 044676715 357 - -DGYAG YIEG K TTQENFYRFIKKAIEK- ^■I- -EGSNYFI- -DKIDREDFLRKQRTFDNGSIPHQIHLQEM 419

WP 044680361 357 - -DGYAG YIEG K TTQENFYRFIKKAIEK- ^■I- -EGSNYFI- -DKIDREDFLRKQRTFDNGSIPHQIHLQEM 419

WP 044681799 357 - -DGYAG YIEG K TTQENFYRFIKKAIEK- ^■I- -EGSDYFI- -DKIDREDFLRKQRTFDNGSIPHQIHLQEM 419

WP 049533112 357 - -KGYAG YIEN G VKQDEFYKYLKGILLQ- ^■I- -NGSGDFL- -DKIDREDFLRKQRTFDNGSIPHQIHLQEM 419

WP 029090905 316 fyTDYIG YEES K SKEERLFKHIELLLAKeNvlTTVEHALleKNITFASLLPLQRSSRNAVIPYQVHEKEL 403

WP 006506696 361 ksKGYYN YINR K APVDEFYKYVKKCIEK- ^■VdtPEAKQILn —DIELENFLLKQNSRTNGSVPYQMQLDEM 429

AIT42264 357 - -NGYAG YIDG G ASQEEFYKFIKPILEK- ^■M- -DGTEELLv —KLNREDLLRKQRTFDNGSIPHQIHLGEL 419

WP 034440723 363 - -NGYAG YIDG K TSQEDFYKFVKAQLKG- eENGEYFL- -EAIENENFLRKQRSFYNGVIPYQIHLQEL 425

AKQ21048 357 - -NGYAG YIDG G ASQEEFYKFIKPILEK- ^■M- -DGTEELLv —KLNREDLLRKQRTFDNGSIPHQIHLGEL 419

WP 004636532 356 - -NGYAG YIDG K TNQEDFYKYIEKVMKT- ^■IksDKKDYFL- -DKIDREVFLRKQRSFYNSVIPHQIHLQEM 420

WP 002364836 363 - -DGYAG YIAH A VSQLKFYQYVKKIIQD- ^■I- -AGAEYFL- -EKIAQENFLRKQRTFDNGVIPHQIHLAEL 427

WP 016631044 314 - -DGYAG YIAH A VSQLKFYQYVKKIIQD- ^■I- -AGAEYFL- -EKIAQENFLRKQRTFDNGVIPHQIHLAEL 378

EMS75795 100 - -NGYAG YIDG K TTQEDFYKFLKKELNG- ^■I- -AGSERFM- -EKVDQENFLLKQRTTANGVIPHQVHLTEL 162

WP 002373311 363 - -DGYAG YIAH A VSQLKFYQYVKKIIQD- ^■I- -AGAEYFL- -EKIAQENFLRKQRTFDNGVIPHQIHLAEL 427

WP 002378009 363 - -DGYAG YITH A VSQLKFYQYVKKIIQD- ^■I- -AGAEYFL- -EKIAQENFLRKQRTFDNGVIPHQIHLAEL 427

WP 002407324 363 - -DGYAG YITH A VSQLKFYQYVKKIIQD- ^■I- -AGAEYFL- -EKIAQENFLRKQRTFDNGVIPHQIHLAEL 427

WP 002413717 363 - -DGYAG YIAH A VSQLKFYQYVKKIIQD- ^■I- -AGAEYFL- -EKIAQENFLRKQRTFDNGVIPHQIHLAEL 427

WP 010775580 365 - -DGYAG YIAH A VSQLKFYQYVKKIIQD- ^■I- -AGAEYFL- -EKIAQENFLRKQRTFDNGVIPHQIHLAEL 429

WP 010818269 363 - -DGYAG YIAH A VSQLKFYQYVKKIIQD- ^■I- -AGAEYFL- -EKIAQENFLRKQRTFDNGVIPHQIHLAEL 427

WP 010824395 363 —DGYAG YITH A VSQLKFYQYVKKIIQD-^■I--AGAEYFL--EKIAQENFLRKQRTFDNGVIPHQIHLAEL 427

WP 016622645 363 —DGYAG YIAH A VSQLKFYQYVKKIIQD- ^■I- -AGAEYFL- -EKIAQENFLRKQRTFDNGVIPHQIHLAEL 427

WP 033624816 363 —DGYAG YIAH A VSQLKFYQYVKKIIQD- ^■I- -AGAEYFL- -EKIAQENFLRKQRTFDNGVIPHQIHLAEL 427

WP 033625576 363 —DGYAG YIAH A VSQLKFYQYVKKIIQD- ^■I- -AGAEYFL- -EKIAQENFLRKQRTFDNGVIPHQIHLAEL 427

WP 033789179 363 —DGYAG YIAH A VSQLKFYQYVKKIIQD- ^■I- -AGAEYFL- -EKIAQENFLRKQRTFDNGVIPHQIHLAEL 427

WP 002310644 361 —NGYAG YIEG H ATQEDFYKFVKKELTG- ^■I- -RGSEVFL- -TKIEQENFLRKQRTFDNGVIPHQIHLTEL 423

WP 002312694 362 —NGYAG YIEG H ATQEAFYKFVKKELTG- ^■I- -RGSEVFL- -TKIEQENFLRKQRTFDNGVIPHQIHLSEL 424

WP 002314015 362 —NGYAG YIEG H ATQEDFYKFVKKELTG- ^■I- -RGSEVFL- -TKIEQENFLRKQRTFDNGVIPHQIHLTEL 424

WP 002320716 362 —NGYAG YIEG H ATQEDFYKFVKKELTG- ^■I- -RGSEVFL- -TKIEQENFLRKQRTFDNGVIPHQIHLTEL 424

WP 002330729 361 —NGYAG YIEG H ATQEDFYKFVKKELTG- ^■I- -RGSEVFL- -TKIEQENFLRKQRTFDNGVIPHQIHLTEL 423

WP 002335161 362 —NGYAG YIEG H ATQEDFYKFVKKELTG- ^■I- -RGSEVFL- -TKIEQENFLRKQRTFDNGVIPHQIHLTEL 424

WP 002345439 362 —NGYAG YIEG H ATQEDFYKFVKKELTG- ^■I- -RGSEVFL- -TKIEQENFLRKQRTFDNGVIPHQIHLTEL 424

WP 034867970 355 —NGYAG YIKG K TTQEEFYKFVKKELSG- ^■V- -VGSEPFL- -EKIDQETFLLKQRTYTNGVIPHQVHLIEL 417

WP 047937432 362 —NGYAG YIEG H ATQEDFYKFVKKELTG- ^■I- -RGSEVFL- -TKIEQENFLRKQRTFDNGVIPHQIHLTEL 424

WP 010720994 355 —NGYAG YIKG K TTQEEFYKFVKKELSG- ^■V- -VGSEPFL- -EKIDQETFLLKQRTYTNGVIPHQVHLIEL 417

WP 010737004 355 —NGYAG YIKG K TTQEEFYKFVKKELSG- ^■V- -VGSEPFL- -EKIDQETFLLKQRTYTNGVIPHQVHLIEL 417

WP 034700478 355 —NGYAG YIKG K TTQEEFYKFVKKELSG- ^■V- -VGSEPFL- -EKIDQETFLLKQRTYTNGVIPHQVHLIEL 417

WP 007209003 359 —NGYAG YIDG K TKEEEFYKYLKTTLVQ- kSGYQYFI- -EKIEQENFLRKQRIYDNGVIPHQVHAEEL 421

WP 023519017 355 —NGYAG YVKG K ATQEDFYKFLRTELAG- ^■L- -EESQSIM- -EKIDLEIYLLKQRTFANGVIPHQIHLVEM 417

WP 010770040 358 —SGYAG YVEN S VTQAEFYKYIKKAIEK- ^■V- -PGAEYFL- -EKIEQETFLDKQRTFNNGVI PHQIHLEEL 422

WP 048604708 354 —DGYAG YIDN S TSQEKFYKYITNLIEK- ^■I- -DGAEYFL- -KKIENEDFLRKQRTFDNGIIPHQIHLEEL 418

WP 010750235 355 —DGYAG YIDG K TTQADFYKFLKKELTG- ^■V- -PGSEPML- -AKIDQENFLLKQRTPTNGVIPHQVHLTEF 417

AII16583 396 —NGYAG YIDG G ASQEEFYKFIKPILEK- ^■M- -DGTEELL —KLNREDLLRKQRTFDNGSIPHQIHLGEL 458

WP 029073316 367 kkNNYCN YINH K TPVDEFYKYIKKLIEK- ^■IddPDVKTILn —KIELESFMLKQNSRTNGAVPYQMQLDEL 435

WP 031589969 367 kkNNYCN YINH K TPVDEFYKYIKKLIEK- ^■IddPDVKTILn —KIELESFMLKQNSRTNGAVPYQMQLDEL 435

KDA45870 354 -iSGYAG YIDG K VSEEDFYKYTKKTLKG- ^■I- -PETEEILq —KIDANNYLRKQRTFDNGAIPHQVHLKEL 417

WP 039099354 360 YVDG K -SKEDFYGDITKALKNnPdhPIVSEIKk —LIELDQFMPKQRTKDNGAIPHQLHQQEL 425

AKP02966 349 —QAYDD YINK K KELYTSLKKFLKVaLp -TNLAKEAe -EKISKGTYLVKPRNSENGWPYQLNKIEM 415

WP 010991369 363 —HGYAG YIDG - TKQADFYKYMKMTLEN- ^■I- -EGADYFI- -AKIEKENFLRKQRTFDNGAIPHQLHLEEL 425

WP 033838504 363 —HGYAG YIDG - TKQADFYKYMKMTLEN- ^■I- -EGADYFI- -AKIEKENFLRKQRTFDNGAIPHQLHLEEL 425

EHN60060 366 —HGYAG YIDG - TKQADFYKYMKMTLEN- ^■I- -EGADYFI- -AKIEKENFLRKQRTFDNGAIPHQLHLEEL 428

EFR89594 132 —HGYAG YIDG - TKQADFYKYMKTTLEN- ^■I- -EGADYFI- -AKIEKENFLRKQRTFDNGAIPHQLHLEEL 194

WP 038409211 363 —DGYAG YIDG - TTQEKFYKYMKKMLAN- ^■I- -DGADYFI- -DQIEEENFLRKQRTFDNGTIPHQLHLEEL 425

EFR95520 1 - MKKMLAN- ^■I- -DGADYFI- -DQIEEENFLRKQRTFDNGTIPHQLHLEEL 44

WP 003723650 363 —DGYAG YIDG - TKQVDFYKYLKTILEN- ^■I- -EGSDYFI- -AKIEEENFLRKQRTFDNGAIPHQLHLEEL 425

WP 003727705 363 —DGYAG YIDG - TKQVDFYKYLKTTLEN- ^■V- -EGADYFI- -TKIEEENFLRKQRTFDNGVIPHQLHLEEL 425

WP 003730785 363 —DGYAG YIDG - TKQVDFYKYLKTTLEN- ^■V- -EGADYFI- -TKIEEENFLRKQRTFDNGVIPHQLHLEEL 425

WP 003733029 363 —HGYAG YISG - TKQADFYKYMKATLEK- ^■I- -EGADYFI- -AKIEEENFLRKQRTFDNGVIPHQLHLEEL 425

WP 003739838 363 —DGYAG YIDG - TKQVDFYKYLKTLLEN- ^■I- -EGADYFI- -AKIEEENFLRKQRTFDNGAIPHQLHLEEL 425

WP 014601172 363 —DGYAG YIDG - TKQVDFYKYLKTILEN--I--EGADYFI---AKIEEENFLRKQRTFDNGAIPHQLHLEEL 425

WP 023548323 363 —DGYAG YIDG - TKQVDFYKYLKTTLEN- -V- -EGADYFI-- -TKIEEENFLRKQRTFDNGVIPHQLHLEEL 425

WP 031665337 363 —DGYAG YIDG - TKQVDFYKYLKTILEN- -I- -EGSDYFI-- -AKIEEENFLRKQRTFDNGAIPHQLHLEEL 425

WP 031669209 363 —HGYAG YISG - TKQADFYKYMKATLEK- -I- -EGADYFI-- -AKIEEENFLRKQRTFDNGVIPHQLHLEEL 425

WP 033920898 363 —DGYAG YIDG - TKQVDFYKYLKTILEN- -I- -EGADYFI-- -AKIEEENFLRKQRTFDNGAIPHQLHLEEL 425

AKI42028 366 —DGYAG YIDG - TKQVDFYKYLKTILEN- -I- -EGADYFI-- -AKIEEENFLRKQRTFDNGAIPHQLHLEEL 428

AKI50529 366 —DGYAG YIDG - TKQVDFYKYLKTILEN- -I- -EGADYFI-- -AKIEEENFLRKQRTFDNGAIPHQLHLEEL 428

EFR83390

WP 046323366 363 —DGYAG YIEG - TKQEAFYKYMKKMLEH- -V- -EGADYFI-- -NQIEEENFLRKQRTFDNGAIPHQLHLEEL 425

AKE81011 373 —NGYAG YIDG G ASQEEFYKFIKPILEK- -M- -DGTEELLv- --KLNREDLLRKQRTFDNGSIPHQIHLGEL 435

CU082355 365 kvKGYYN YINR K APVDEFYKFVKKCIEK- -VdtPEAKQILh- --DIELENFLLKQNSRTNGSVPYQMQLDEM 433

WP 033162887 366 klHNYLG YIKY D TPVEEFYKYIKGLLAK- -VdtDEAREILe- --RIDLEKFMLKQNSRTNGSIPYQMQKDEM 434

AGZ 01981 390 —NGYAG YIDG G ASQEEFYKFIKPILEK- -M- -DGTEELLv- --KLNREDLLRKQRTFDNGSIPHQIHLGEL 452

AKA60242 357 —NGYAG YIDG G ASQEEFYKFIKPILEK- -M- -DGTEELLv- --KLNREDLLRKQRTFDNGSIPHQIHLGEL 419

AKS40380 357 —NGYAG YIDG G ASQEEFYKFIKPILEK- -M- -DGTEELLv- --KLNREDLLRKQRTFDNGSIPHQIHLGEL 419

4UN5 B 361 —NGYAG YIDG G ASQEEFYKFIKPILEK- -M- -DGTEELLv- --KLNREDLLRKQRTFDNGSIPHQIHLGEL 423

WP 010922251 420 HAILRRQEDFYPFLKD--NRE KIEKILTFRIPYYVGPL ARG-^■n- SRFAWMTR KSEETITPWNFE|E|WDKGA

WP ^"039695303 423 HAILRRQGDYYPFLKE- -KQD RIEKILTFRIPYYVGPL VRKE )-- SRFAWAEY RSDEKITPWNFDKVIDKEK

WP ^"045635197 420 NAILRRQGEYYPFLKD- -NKE KIEKILTFRIPYYVGPL ARGNί— RDFAWLTR :NSDEAIRPWNFEEIVDKAS

5AXW A 184 KQLLKVQKAYHQLDQSfi—D TYIDLLETRRTYYEGPG Eg- SPFGWKDI

WP 009880683 104 HAILRRQEDFYPFLKD- -NRE KIEKILTFRIPYYVGPL ARG- ^■n- SRFAWMTR KSEETITPWNFEEWDKGA

WP ^"010922251 420 HAILRRQEDFYPFLKD- -NRE KIEKILTFRIPYYVGPL ARG- ^■n- SRFAWMTR KSEETITPWNFEEWDKGA

WP ^"011054416 420 HAILRRQEDFYPFLKD- -NRE KIEKILTFRIPYYVGPL ARG- ^■n- SRFAWMTR KSEETITPWNFEEWDKGA

WP ^"011284745 420 HAILRRQEDFYPFLKD- -NRE KIEKILTFRIPYYVGPL ARG- ^■n- SRFAWMTR KSEETITPWNFEEWDKGA

WP ^"011285506 420 HAILRRQEDFYPFLKD- -NRE KIEKILTFRIPYYVGPL ARG- ^■n- SRFAWMTR KSEETITPWNFEEWDKGA

WP ^"011527619 420 HAILRRQEDFYPFLKD- -NRE KIEKILTFRIPYYVGPL ARG- ^■n- SRFAWMTR KSEETITPWNFEEWDKGA

WP ^"012560673 420 HAILRRQEDFYPFLKD- -NRE KIEKILTFRIPYYVGPL ARG- ^■n- SRFAWMTR KSEETITPWNFEEWDKGA

WP ^"014407541 420 HAILRRQEDFYPFLKD- -NRE KIEKILTFRIPYYVGPL ARG- ^■n- SRFAWMTR KSEETITPWNFEEWDKGA

WP ^"020905136 420 HAILRRQEDFYPFLKD- -NRE KIEKILTFRIPYYVGPL ARG- ^■n- SRFAWMTR KSEETITPWNFEEWDKGA

WP ^"023080005 420 HAILRRQEDFYPFLKD- -NRE KIEKILTFRIPYYVGPL ARG- ^■n- SRFAWMTR KSEETITPWNFEEWDKGA

WP ^"023610282 420 HAILRRQEDFYPFLKD- -NRE KIEKILTFRIPYYVGPL ARG- ^■n- SRFAWMTR KSEETITPWNFEEWDKGA

WP ^"030125963 420 HAILRRQEDFYPFLKD- -NRE KIEKILTFRIPYYVGPL ARG- ^■n- SRFAWMTR KSEETITPWNFEEWDKGA

WP ^"030126706 420 HAILRRQEDFYPFLKD- -NRE KIEKILTFRIPYYVGPL ARG- ^■n- SRFAWMTR KSEETITPWNFEEWDKGA

WP ^"031488318 420 HAILRRQEDFYPFLKD- -NRE KIEKILTFRIPYYVGPL ARG- ^■n- SRFAWMTR KSEETITPWNFEEWDKGA

WP ^"032460140 420 HAILRRQEDFYPFLKD- -NRE KIEKILTFRIPYYVGPL ARG- ^■n- SRFAWMTR KSEETITPWNFEEWDKGA

WP ^"032461047 420 HAILRRQEDFYPFLKD- -NRE KIEKILTFRIPYYVGPL ARG- ^■n- SRFAWMTR KSEETITPWNFEEWDKGA

WP ^"032462016 420 HAILRRQEDFYPFLKD- -NRE KIEKILTFRIPYYVGPL ARG- ^■n- SRFAWMTR KSEETITPWNFEEWDKGA

WP ^"032462936 420 HAILRRQEDFYPFLKD- -NRE KIEKILTFRIPYYVGPL ARG- ^■n- SRFAWMTR KSEETITPWNFEEWDKGA

WP ^"032464890 420 HAILRRQEDFYPFLKD- -NRE KIEKILTFRIPYYVGPL ARG- ^■n- SRFAWMTR KSEETITPWNFEEWDKGA

WP ^"033888930 245 HAILRRQEDFYPFLKD- -NRE KIEKILTFRIPYYVGPL ARG- ^■n- SRFAWMTR KSEETITPWNFEEWDKGA

WP ^"038431314 420 HAILRRQEDFYPFLKD- -NRE KIEKILTFRIPYYVGPL ARG- ^■n- SRFAWMTR KSEETITPWNFEEWDKGA

WP ^"038432938 420 HAILRRQEDFYPFLKD- -NRE KIEKILTFRIPYYVGPL ARG- ^■n- SRFAWMTR KSEETITPWNFEEWDKGA

WP ^"038434062 420 HAILRRQEDFYPFLKD- -NRE KIEKILTFRIPYYVGPL ARG- ^■n- SRFAWMTR KSEETITPWNFEEWDKGA

BAQ51233 331 HAILRRQEDFYPFLKD- -NRE KIEKILTFRIPYYVGPL ARG- ^■n- SRFAWMTR KSEETITPWNFEEWDKGA

KGE60162

KGE60856

WP 002989955 420 HAILRRQEDFYPFLKD- -NRE KIEKILTFRIPYYVGPL ARG-n -SRFAWMTR- KSEETITPWNFEEWDKGA

WP ^"003030002 420 HAILRRQEEHYPFLKE- -NQD KIEKILTFRIPYYVGPL ARKG- -SRFAWAEY- KADEKITPWNFDDILDKEK

WP ^"003065552 423 HAILRRQGDYYPFLKE- -NQD RIEKILTFRIPYYVGPL ARKD- -SRFSWAEY- HSDEKITPWNFDKVIDKEK

WP ^"001040076 421 RAIIRRQSEYYPFLKE- -NLD RIEKILTFRIPYYVGPL AREK- -SDFAWMTR- KTDDSIRPWNFEDLVDKEK

WP ^"001040078 421 KAIIRRQSEYYPFLKE- -NQD RIEKILTFRIPYYIGPL AREK- -SDFAWMTR- KTDDSIRPWNFEDLVDKEK

WP ^"001040080 421 KAIIRRQSEYYPFLKE- -NQD RIEKILTFRIPYYIGPL AREK- -SDFAWMTR- KTDDSIRPWNFEDLVDKEK

WP ^"001040081 421 KAIIRRQSEYYPFLKE- -NQD RIEKILTFRIPYYIGPL AREK- -SDFAWMTR- KTDDSIRPWNFEDLVDKEK

WP ^"001040083 421 KAIIRRQSEYYPFLKE- -NQD RIEKILTFRIPYYIGPL AREK- -SDFAWMTR- KTDDSIRPWNFEDLVDKEK

WP ^"001040085 421 KAIIRRQSEYYPFLKE- -NQD RIEKILTFRIPYYIGPL AREK- -SDFAWMTR- KTDDSIRPWNFEDLVDKEK

WP 001040087 421 KAIIRRQSEYYPFLKE--NQD RIEKILTFRIPYYIGPL AREK--SDFAWMTR---KTDDSIRPWNFEDLVDKEK 4E37

WP ^"001040088 421 KAIIRRQSEYYPFLKE- -NQD RIEKILTFRIPYYIGPL AREK- -SDFAWMTR- - -KTDDSIRPWNFEDLVDKEK 4E 37

WP ^"001040089 421 KAIIRRQSEYYPFLKE- -NQD RIEKILTFRIPYYIGPL AREK- -SDFAWMTR- - -KTDDSIRPWNFEDLVDKEK 4 E 37

WP ^"001040090 421 KAIIRRQSEYYPFLKE- -NQD RIEKILTFRIPYYIGPL AREK- -SDFAWMTR- - -KTDDSIRPWNFEDLVDKEK 4 E 37

WP ^"001040091 421 KAIIRRQSEYYPFLKE- -NQD RIEKILTFRIPYYIGPL AREK- -SDFAWMTR- - -KTDDSIRPWNFEDLVDKEK 4 E 37

WP ^"001040092 421 KAIIRRQSEYYPFLKE- -NQD KIEKILTFRIPYYVGPL ARGN- -SDFAWMTR- - -KTDDSIRPWNFEDLVDKEK 4 E 37

WP ^"001040094 421 RAIIRRQSEYYPFLKE- -NLD RIEKILTFRIPYYVGPL AREK- -SDFAWMTR- - -KTDDSIRPWNFEDLVDKEK 4 E 37

WP ^"001040095 421 RAIIRRQSEYYPFLKE- -NLD RIEKILTFRIPYYVGPL AREK- -SDFAWMTR- - -KTDDSIRPWNFEDLVDKEK 4 E 37

WP ^"001040096 421 RAIIRRQSEYYPFLKE- -NLD RIEKILTFRIPYYVGPL AREK- -SDFAWMTR- - -KTDDSIRPWNFEDLVDKEK 4 E 37

WP ^"001040097 421 RAIIRRQSEYYPFLKE- -NLD RIEKILTFRIPYYVGPL AREK- -SDFAWMTR- - -KTDDSIRPWNFEDLVDKEK 4 E 37

WP ^"001040098 421 RAIIRRQSEYYPFLKE- -NLD RIEKILTFRIPYYVGPL AREK- -SDFAWMTR- - -KTDDSIRPWNFEDLVDKEK 4 E 37

WP ^"001040099 421 RAIIRRQSEYYPFLKE- -NLD RIEKILTFRIPYYVGPL AREK- -SDFAWMTR- - -KTDDSIRPWNFEDLVDKEK 4 E 37

WP ^"001040100 421 RAIIRRQSEYYPLLKE- -NLD RIEKILTFRIPYYVGPL AREK- -SDFAWMTR- - -KTDDSIRPWNFEDLVDKEK 4 E 37

WP ^"001040104 421 KAIIRRQSEYYPFLKE- -NQD RIEKILTFRIPYYIGPL AREK- -SDFAWMTR- - -KTDDSIRPWNFEDLVDKEK 4 E 37

WP ^"001040105 421 KAIIRRQSEYYPFLKE- -NQD RIEKILTFRIPYYIGPL AREK- -SDFAWMTR- - -KTDDSIRPWNFEDLVDKEK 4 E 37

WP ^"001040106 421 KAIIRRQSEYYPFLKE- -NLD RIEKILTFRIPYYVGPL AREK- -SDFAWMTR- - -KTDDSIRPWNFEELVDKEA 4 E 37

WP ^"001040107 421 KAIIRRQSEYYPFLKE- -NLD RIEKILTFRIPYYVGPL AREK- -SDFAWMTR- - -KTDDSIRPWNFEELVDKEA 4 E 37

WP ^"001040108 421 KAIIRRQSEYYPFLKE- -NLD RIEKILTFRIPYYVGPL AREK- -SDFAWMTR- - -KTDDSIRPWNFEELVDKEA 4 E 37

WP ^"001040109 421 KAIIRRQSEYYPFLKE- -NLD RIEKILTFRIPYYVGPL AREK- -SDFAWMTR- - -KTDDSIRPWNFEELVDKEA 4 E 37

WP ^"001040110 421 KAIIRRQSEYYPFLKE- -NLD RIEKILTFRIPYYVGPL AREK- -SDFAWMTR- - -KTDDSIRPWNFEELVDKEA 4 E 37

WP ^"015058523 421 KAIIRRQSEYYPFLKE- -NQD KIEKILTFRIPYYVGPL ARGN- -SDFAWMTR- - -KTDDSIRPWNFEDLVDKEK 4 E 37

WP ^"017643650 421 RAIIRRQSEYYPFLKE- -NLD RIEKILTFRIPYYVGPL AREK- -SDFAWMTR- - -KTDDSIRPWNFEDLVDKEK 4 E 37

WP ^"017647151 421 KAIIRRQSEYYPFLKE- -NLD RIEKILTFRIPYYVGPL AREK- -SDFAWMTR- - -KTDDSIRPWNFEELVDKEA 4 E 37

WP ^"017648376 421 KAIIRRQSEYYPFLKE- -NLD RIEKILTFRIPYYVGPL AREK- -SDFAWMTR- - -KTDDSIRPWNFEELVDKEA 4 E 37

WP ^"017649527 421 KAIIRRQSEYYPFLKE- -NQD RIEKILTFRIPYYIGPL AREK- -SDFAWMTR- - -KTDDSIRPWNFEDLVDKEK 4 E 37

WP ^"017771611 421 KAIIRRQSEYYPFLKE- -NLD RIEKILTFRIPYYVGPL AREK- -SDFAWMTR- - -KTDDSIRPWNFEELVDKEA 4 E 37

WP ^"017771984 421 KAIIRRQSEYYPFLKE- -NQD RIEKILTFRIPYYIGPL AREK- -SDFAWMTR- - -KTDDSIRPWNFEDLVDKEK 4 E 37

CFQ25032 421 KAIIRRQSEYYPFLKE- -NQD RIEKILTFRIPYYIGPL AREK- -SDFAWMTR- - -KTDDSIRPWNFEDLVDKEK 4 E 37

CFV16040 421 KAIIRRQSEYYPFLKE- -NQD RIEKILTFRIPYYIGPL AREK- -SDFAWMTR- - -KTDDSIRPWNFEDLVDKEK 4 E 37

KLJ37842 421 KAIIRRQSEYYPFLKE- -NQD RIEKILTFRIPYYIGPL AREK- -SDFAWMTR- - -KTDDSIRPWNFEDLVDKEK 4 E 37

KLJ72361 421 KAIIRRQSEYYPFLKE- -NQD RIEKILTFRIPYYIGPL AREK- -SDFAWMTR- - -KTDDSIRPWNFEDLVDKEK 4 E 37

KLL20707 421 KAIIRRQSEYYPFLKE- -NQD RIEKILTFRIPYYIGPL AREK- -SDFAWMTR- - -KTDDSIRPWNFEDLVDKEK 4 E 37

KLL42645 421 KAIIRRQSEYYPFLKE- -NLD RIEKILTFRIPYYVGPL AREK- -SDFAWMTR- - -KTDDSIRPWNFEELVDKEA 4 E 37

WP 047207273 421 KAIIRRQSEYYPFLKE- -NQD RIEKILTFRIPYYIGPL AREK- -SDFAWMTR- - -KTDDSIRPWNFEDLVDKEK 4 E 37

WP ^"047209694 421 RAIIRRQSEYYPFLKE- -NLD RIEKILTFRIPYYVGPL AREK- -SDFAWMTR- - -KTDDSIRPWNFEDLVDKEK 4 E 37

WP ^"050198062 421 KAIIRRQSEYYPFLKE- -NQD RIEKILTFRIPYYIGPL AREK- -SDFAWMTR- - -KTDDSIRPWNFEDLVDKEK 4 E 37

WP ^"050201642 421 KAIIRRQSEYYPFLKE- -NQD RIEKILTFRIPYYIGPL AREK- -SDFAWMTR- - -KTDDSIRPWNFEDLVDKEK 4 E 37

WP ^"050204027 421 KAIIRRQSEYYPFLKE- -NLD RIEKILTFRIPYYVGPL AREK- -SDFAWMTR- - -KTDDSIRPWNFEELVDKEA 4 E 37

WP ^"050881965 421 KAIIRRQSEYYPFLKE- -NQD RIEKILTFRIPYYIGPL AREK- -SDFAWMTR- - -KTDDSIRPWNFEDLVDKEK 4 E 37

WP 050886065 421 KDIIRRQSEYYPFLKE--NQD RIEKILTFRIPYYIGPL AREK-- SDFAWMTR—-KTDDSIRPWNFEDLVDKEK 487

AHN30376 421 KAIIRRQSEYYPFLKE- -NQD KIEKILTFRIPYYVGPL ARGN-- SDFAWMTR— -KTDDSIRPWNFEDLVDKEK 4 87

EA078426 421 KAIIRRQSEYYPFLKE- -NQD RIEKILTFRIPYYIGPL AREK-- SDFAWMTR— -KTDDSIRPWNFEDLVDKEK 4 87

CCW42055 421 RAIIRRQSEYYPFLKE- -NLD RIEKILTFRIPYYVGPL AREK-- ^■SDFAWMTR— -KTDDSIRPWNFEELVDKEA 4 87

WP 0030415 02 420 HAILRRQGEHYPFLKE- -NQD KIEKILTFRIPYYVGPL ARKG-- SRFAWAEY— -KADEKITPWNFDDILDKEK 4 86

WP 0375937 52 421 HAILRRQGEHYPFLKE- -NQD KIEKILTFRIPYYVGPL ARKG-- SRFAWAEY— -KADEKITPWNFDDILDKEK 4 87

WP 0495166 84 421 HAILRRQGEHYPFLKE- -NQD KIEKILTFRIPYYVGPL ARKG-- ^■SRFAWAEY— -KADEKITPWNFDDILDKEK 4 87

GAD46167 420 HAILRRQGEHYPFLKE- -NQD KIEKILTFRIPYYVGPL ARKG-- ^■SRFAWAEY— -KADEKITPWNFDDILDKEK 4 86

WP 0183634 70 421 HAILRRQGDYYPFLKE- -NQE EIEKILTFRIPYYVGPL ARKD-- ^■SRFAWAEY— -RSDEKITPWNFDKVIDKEK 4 87

WP 0030438 19 430 HAILRRQEEFYPFLKE- -NRE KIEKILTFRIPYYVGPL ARG-n- SRFAWLTR— -KSEEAITPWNFEEWDKGA 4 96

WP 0062696 58 420 HAILRRQGEHYPFLKE- -NQD KIEKILTFRIPYYVGPL ARKG-- ^■SRFAWAEY— -KADEKITPWNFDDILDKEK 4 86

WP 0488008 89 420 HAILRRQGEHYPFLKE- -NQD KIEKILTFRIPYYVGPL VRKG-- ^■SRFAWAEY— -KADEKITPWNFDDILDKEK 4 86

WP 0127671 06 420 HAILRRQEDFYPFLKD- -NRE KIEKILTFRIPYYVGPL ARG-n- SRFAWMTR— -KSEETITPWNFEEWDKGA 4 86

WP 0146123 33 420 HAILRRQEDFYPFLKD- -NRE KIEKILTFRIPYYVGPL ARG-n- SRFAWMTR— -KSEETITPWNFEEWDKGA 4 86

WP 0150170 95 420 HAILRRQEDFYPFLKD- -NRE KIEKILTFRIPYYVGPL ARG-n- ^■SRFAWMTR— -KSEETITPWNFEEWDKGA 4 86

WP 0150576 49 420 HAILRRQEDFYPFLKD- -NRE KIEKILTFRIPYYVGPL ARG-n- ^■SRFAWMTR— -KSEETITPWNFEEWDKGA 4 86

WP 0483272 15 420 HAILRRQEDFYPFLKD- -NRE KIEKILTFRIPYYVGPL ARG-n- ^■SRFAWMTR— -KSEETITPWNFEEWDKGA 4 86

WP 0495193 24 420 HAILRRQEDFYPFLKD- -NRE KIEKILTFRIPYYVGPL ARG-n- ^■SRFAWMTR— -KSEETITPWNFEEWDKGA 4 86

WP 0125159 31 420 HAILRRQEVFYPFLKD- -NRK KIESLLTFRIPYYVGPL ARG-h- SRFAWVKR— -KFDGAIRPWNFEEIVDEEA 4 86

WP 0213209 64 420 HAILRRQEVFYPFLKD- -NRK KIESLLTFRIPYYVGPL ARG-h- SRFAWVKR— -KFDGAIRPWNFEEIVDEEA 4 86

WP 0375817 60 420 HAILRRQEVFYPFLKD- -NRK KIESLLTFRIPYYVGPL ARG-h- ^■SRFAWVKR— -KFDGAIRPWNFEEIVDEEA 4 86

WP 0042324 81 420 RTILRRQGEYYPFLKE- -NQA KIEKILTFRIPYYVGPL ARKN-- SRFAWAKY— -HSDEPITPWNFDEWDKEK 4 86

WP 0098545 40 421 HAILRRQGDYYPFLKE- -KQD RIEKILTFRIPYYVGPL VRKD-- ^■SRFAWAEY— -RSDEKITPWNFDKVIDKEK 4 87

WP 0129621 74 421 HAILRRQGEHYAFLKE- -NQA KIEKILTFRIPYYVGPL ARKN-- ^■SRFAWAEY— -HSDEKITPWNFDEIIDKEK 4 87

WP 0396953 03 423 HAILRRQGDYYPFLKE- -KQD RIEKILTFRIPYYVGPL VRKD-- ^■SRFAWAEY— -RSDEKITPWNFDKVIDKEK 4 89

WP 0143349 83 420 HSILRRQGDYYPFLKE- -NQA KIEKILTFRIPYYVGPL ARKD-- SRFAWANY— -HSDEPITPWNFDEWDKEK 4 86

WP 0030992 69 420 KAIIRRQEKFYPFLKE- -NQK KIEKLFTFKIPYYVGPL ANG-q- SSFAWLKR— -QSNESITPWNFEEWDQEA 4 86

AHY15608 420 KAIIRRQEKFYPFLKE- -NQK KIEKLFTFKIPYYVGPL ANG-q- SSFAWLKR— -QSNESITPWNFEEWDQEA 4 86

AHY17476 420 KAIIRRQEKFYPFLKE- -NQK KIEKLFTFKIPYYVGPL ANG-q- ^■SSFAWLKR— -QSNESITPWNFEEWDQEA 4 86

ESR09100

AGM98575 420 KAIIRRQEKFYPFLKE- -NQK KIEKLFTFKIPYYVGPL ANG-q- ^■SSFAWLKR— -QSNESITPWNFEEWDQEA 4 86

ALF27331 420 RAI IRRQAEFYPFLAD- -NQD RIEKILTFRIPYYIGPL ARGK-- SDFSWLSR— -KSADKITPWNFDEIVDKES 4 86

WP 0183724 92 433 QAIILNQSKYYPFLAE- -NKE KIEKILTFRIPYYVGPL ARGN-- SSFAWLQR— -KSDEAIRPWNFEQWDMET 4 99

WP 0456180 28 421 NAIIRRQGEHYPFLQE- -NKE KIEKILTFRIPYYVGPL ARGN-- RDFAWLTR— -NSDQAIRPWNFEEIVDKAR 4 87

WP 0456351 97 420 NAILRRQGEYYPFLKD- -NKE KIEKILTFRIPYYVGPL ARGN-- RDFAWLTR— -NSDEAIRPWNFEEIVDKAS 4 86

WP 0022635 49 420 RAI IRRQAEFYPFLAD- -NQD RIEKLLTFRIPYYVGPL ARGK-- SDFAWLSR— -KSADKITPWNFDEIVDKES 4 86

WP 0022638 87 420 RAI IRRQAEFYPFLAD- -NQD RIEKLLTFRIPYYVGPL ARGK-- SDFAWLSR— -KSADKITPWNFDEIVDKES 4 86

WP 0022649 20 420 HAILRRQGDYYPFLKE- -NQD RIEKILTFRIPYYVGPL ARGK-- ^■SDFAWLSR— -KSADKITPWNFDEIVDKES 4 86

WP 0022690 43 420 RAI IRRQAEFYPFLAD- -NQD RIEKILTFRIPYYVGPL ARGK-- ^■SDFAWLSR— -KSADKITPWNFDEIVDKES 4 86

WP 002269448 420 RAI IRRQAEFYPFLAD--NQD RIEKILTFRIPYYVGPL ARGK--SDFAWLSR—-KSADKITPWNFDEIVDKES 486

WP ^"0022 71977 420 RAI IRRQAEFYPFLAD- -NQD RIEKILTFRIPYYVGPL ARGK- -SDFAWLSR— -KSADKITPWNFDEIVDKES 4 86

WP ^"0022 72766 420 RAI IRRQAEFYPFLAD- -NQD RIEKILTFRIPYYVGPL ARGK- -SDFAWLSR— -KSADKITPWNFDEIVDKES 4 86

WP ^"0022 73241 420 RAI IRRQAEFYPFLAD- -NQD RIEKILTFRIPYYVGPL ARGK- -SDFAWLSR— -KSADKITPWNFDEIVDKES 4 86

WP ^"0022 75430 420 RAI IRRQAEFYPFLAD- -NQD RIEKILTFRIPYYVGPL ARGK- -SDFAWLSR— -KSADKITPWNFDEIVDKES 4 86

WP ^"0022 76448 420 RAI IRRQAEFYPFLAD- -NQD RIEKILTFRIPYYVGPL ARGK- -SDFAWLSR— -KSADKITPWNFDEIVDKES 4 86

WP ^"0022 77050 420 HAILRRQGDYYPFLKE- -NQD RIEKILTFRIPYYVGPL ARKN- -SRFAWAEY— -HSDEAVMPWNFDQVIDKES 4 86

WP ^"0022 77364 420 RAI IRRQAEFYPFLAD- -NQD RIEKILTFRIPYYVGPL ARGK- -SDFAWLSR— -KSADKITPWNFDEIVDKES 4 86

WP ^"0022 79025 420 RAIIRRQSEFYPFLAD- -NQD RIEKILTFRIPYYVGPL ARGK- -SDFAWLSR— -KSADKITPWNFDEIVDKES 4 86

WP ^"0022 79859 420 RAI IRRQAEFYPFLAD- -NQD RIEKILTFRIPYYVGPL ARGK- -SDFAWLSR— -KSADKITPWNFDEIVDKES 4 86

WP ^"0022 80230 420 RAI IRRQAEFYPFLAD- -NQD RIEKILTFRIPYYVGPL ARGK- -SDFAWLSR— -KSADKITPWNFDEIVDKES 4 86

WP ^"0022 81696 420 RAI IRRQAEFYPFLAD- -NQD RIEKILTFRIPYYVGPL ARGK- -SDFAWLSR— -KSADKITPWNFDEIVDKES 4 86

WP ^"0022 82247 420 HAILRRQGDYYPFLKE- -NQD RIEKILTFRIPYYVGPL ARKN- -SRFAWAEY— -HSDEAVTPWNFDQVIDKES 4 86

WP ^"0022 82906 420 RAI IRRQAEFYPFLAD- -NQD RIEKLLTFRIPYYVGPL ARGK- -SDFAWLSR— -KSADKITPWNFDEIVDKES 4 86

WP ^"0022 83846 420 RAI IRRQAEFYPFLAD- -NQD RIEKILTFRIPYYVGPL ARGK- -SDFAWLSR— -KSADKITPWNFDEIVDKES 4 86

WP ^"0022 87255 420 RAI IRRQAEFYPFLAD- -NQD RIEKILTFRIPYYVGPL ARGK- -SDFAWLSR— -KSADKITPWNFDEIVDKES 4 86

WP ^"0022 88990 420 RAI IRRQAEFYPFLAD- -NQD RIEKILTFRIPYYVGPL ARGK- -SDFAWLSR— -KSADKITPWNFDEIVDKES 4 86

WP ^"0022 89641 420 RAI IRRQAEFYPFLAD- -NQD RIEKLLTFRIPYYVGPL ASGK- -SDFAWLSR— -KSADKITPWNFDEIVDKES 4 86

WP ^"0022 90427 420 RAI IRRQAEFYPFLAD- -NQD RIEKILTFRIPYYVGPL ARGK- -SDFAWLSR— -KSADKITPWNFDEIVDKES 4 86

WP ^"0022 95753 420 RAI IRRQAEFYPFLAD- -NQD RIEKILTFRIPYYVGPL ARGK- -SDFAWLSR— -KSADKITPWNFDEIVDKES 4 86

WP ^"0022 96423 420 RAI IRRQAEFYPFLAD- -NQD RIEKILTFRIPYYVGPL ARGK- -SDFAWLSR— -KSADKITPWNFDEIVDKES 4 86

WP ^"0023 04487 430 HAILRRQGEHYPFLKE- -NQD RIEKILTFRIPYYVGPL VRKG- -SRFAWAEY— -KADEKITPWNFDDILDKEK 4 96

WP ^"0023 05844 420 RAI IRRQAEFYPFLAD- -NQD RIEKILTFRIPYYVGPL ARGK- -SDFAWLSR— -KSADKITPWNFDEIVDKES 4 86

WP ^"0023 07203 420 RAI IRRQAEFYPFLAD- -NQD RIEKILTFRIPYYVGPL ARGK- -SDFAWLSR— -KSADKITPWNFDEIVDKES 4 86

WP ^"0023 10390 420 RAI IRRQAEFYPFLAD- -NQD RIEKILTFRIPYYVGPL ARGK- -SDFAWLSR— -KSADKITPWNFDEIVDKES 4 86

WP ^"0023 52408 420 RAI IRRQAEFYPFLAD- -NQD RIEKILTFRIPYYVGPL ARGK- -SDFAWLSR— -KSADKITPWNFDEIVDKES 4 86

WP ^"0129 97688 420 RAI IRRQAEFYPFLAD- -NQD RIEKILTFRIPYYVGPL ARGK- -SDFAWLSR— -KSADKITPWNFDEIVDKES 4 86

WP ^"θ146 77909 420 RAI IRRQAEFYPFLAD- -NQD RIEKILTFRIPYYVGPL ARGK- -SDFAWLSR— -KSADKITPWNFDEIVDKES 4 86

WP ^"0193 12892 420 RAI IRRQAEFYPFLAD- -NQD RIEKILTFRIPYYVGPL ARGK- -SDFAWLSR— -KSADKITPWNFDEIVDKES 4 86

WP ^"0193 13659 420 RAI IRRQAEFYPFLAD- -NQD RIEKLLTFRIPYYVGPL ARGK- -SDFAWLSR— -KSADKITPWNFDEIVDKES 4 86

WP ^"0193 14093 420 RAI IRRQAEFYPFLAD- -NQD RIEKILTFRIPYYVGPL ARGK- -SDFAWLSR— -KSADKITPWNFDEIVDKES 4 86

WP ^"0193 15370 420 RAI IRRQAEFYPFLAD- -NQD RIEKILTFRIPYYVGPL ARGK- -SDFAWLSR— -KSADKITPWNFDEIVDKES 4 86

WP ^"0198 03776 420 RAI IRRQAEFYPFLAD- -NQD RIEKLLTFRIPYYVGPL ARGK- -SDFAWLSR— -KSADKITPWNFDEIVDKES 4 86

WP ^"0198 05234 420 RAI IRRQAEFYPFLAD- -NQD RIEKILTFRIPYYVGPL ARGK- -SDFAWLSR— -KSADKITPWNFDEIVDKES 4 86

WP ^"0247 83594 420 RAI IRRQAEFYPFLAD- -NQD RIEKLLTFRIPYYVGPL ARGK- -SDFAWLSR— -KSADKITPWNFDEIVDKES 4 86

WP ^"0247 84288 420 HAILRRQGDYYPFLKE- -NQD RIEKILTFRIPYYVGPL ARKN- -SRFAWAEY— -HSDEAVTPWNFDQVIDKES 4 86

WP ^"0247 84666 420 RAI IRRQAEFYPFLAD- -NQD RIEKILTFRIPYYVGPL ARGK- -SDFAWLSR— -KSADKITPWNFDEIVDKES 4 86

WP ^"0247 84894 420 RAI IRRQAEFYPFLAD- -NQD RIEKLLTFRIPYYVGPL ASGK- -SDFAWLSR— -KSADKITPWNFDEIVDKES 4 86

WP ^"0247 86433 420 HAILRRQGDYYPFLKE- -NQD RIEKILTFRIPYYVGPL ARKN- -SRFAWAEY— -HSDEAVTPWNFDQVIDKES 4 86

WP 049473442 420 RAI IRRQAEFYPFLAD--NQD RIEKILTFRIPYYVGPL ARGK-- SDFAWLSR—-KSADKITPWNFDEIVDKES 486

WP ^"049474547 420 RAI IRRQAEFYPFLAD- -NQD RIEKLLTFRIPYYVGPL ASGK-- SDFAWLSR— -KSADKITPWNFDEIVDKES 486

EMC03581 413 RAI IRRQAEFYPFLAD- -NQD RIEKILTFRIPYYVGPL ARGK-- SDFAWLSR— -KSADKITPWNFDEIVDKES 479

WP 000428612 421 NAILRRQGEHYPFLKE- -NKE KIEKILTFRIPYYVGPL ARGN-- RDFAWLTR— -NSDQAIRPWNFEEIVDKAS 487

WP ^"000428613 421 NAILRRQGEHYPFLKD- -NKE RIEKILTFRIPYYVGPL ARGN-- RDFAWLTR— -NSDEAIRPWNFEEIVDKAS 487

WP ^"049523028 420 NAILRHQGEYYPFLKE- -NKD KIEQILTFRIPYYVGPL ARGN-- ^■SDFAWLSR— -NSDEAIRPWNFEEMVDKSS 486

WP ^"003107102 389 KSIIRRQEKYYPFLKD- -KQV RIEKIFTFRIPYFVGPL ANG-n- SSFAWVKR— -RSNESITPWNFEEWEQEA 455

WP ^"054279288 422 QAILERQQAYYPFLKD- -NQE KIEKILTFRIPYYIGPL ARG-n- SRFAWLTR— -TSDQKITPWNFDEMVDQEA 488

WP ^"049531101 421 NAILRRQGEHYPFLKE- -NRE KIEKILTFRIPYYVGPL ARGN-- ^■RDFAWLTR— -NSDQAIRPWNFEEIVDKAS 487

WP ^"049538452 421 NAILRRQGEHYPFLKE- -NKE KIEKILTFRIPYYVGPL ARGN-- ^■RDFAWLTR— -NSDQAIRPWNFEEIVDKAS 487

WP ^"049549711 421 NAILRRQGEHYPFLKE- -NKE KIEKILTFRIPYYVGPL ARGN-- ^■RDFAWLTR— -NSDQAIRPWNFEEIVDKAS 487

WP ^"007896501 422 HAILRRQEKYYPFLAE- -QKE KIEQLLCFRIPYYVGPL AKGGn- SSFAWLKR— -RSDEPITPWNFKDWDEEA 489

EFR44625 374 HAILRRQEKYYPFLAE- -QKE KIEQLLCFRIPYYVGPL AKGGn- SSFAWLKR— -RSDEPITPWNFKDWDEEA 441

WP 002897477 420 NAILRRQGEHYPFLKE- -NRE KIEKILTFRIPYYVGPL ARDN-- RDFSWLTR— -NSDEPIRPWNFEEWDKAR 486

WP ^"002906454 420 NAILRRQGEHYLFLKE- -NRE KIEKILAFRI PYYVGPL ARGN-- ^■RDFAWLTR— -NSDQAIRPWNFEEWDKAS 486

WP ^"009729476 421 NAILRRQGEHYPFLKE- -NKE KIEKILTFRIPYYVGPL ARGN-- ^■RDFAWLTR— -NSDQAIRPWNFEEIVDKAS 487

CQR24647 421 KAILRRQGEFYPFLKE- -NAE KIQQILTFKI PYYVGPL ARGN-- SRFAWASY— -NSNEKMTPWNFDNVIDKTS 487

WP 000066813 421 NAIIRRQGEHYPFLQE- -NKE KIEKILTFRIPYYVGPL ARGN-- GDFAWLTR— -NSDQAIRPWNFEEIVDQAS 487

WP ^"009754323 421 NAILRRQGEHYPLLKE- -NKE KIEKILTFRIPYYVGPL ARGN-- ^■RDFAWLTR— -NSDQAIRPWNFEEIVDKAS 487

WP ^"044674937 420 HAI IRRQAEFYPFLVE- -NQD KIEKILTFRIPYYVGPL ARGK-- SEFAWLNR— -KSDEKIRPWNFDEMVDKET 486

WP ^"044676715 420 HAI IRRQAEFYPFLVE- -NQD KIEKILTFRIPYYVGPL ARGK-- SEFAWLNR— -KSDEKIRPWNFDEMVDKET 486

WP ^"044680361 420 HAI IRRQAEFYPFLVE- -NQD KIEKILTFRIPYYVGPL ARGK-- ^■SEFAWLNR— -KSDEKIRPWNFDEMVDKET 486

WP ^"044681799 420 HAI IRRQAEFYPFLVE- -NQD KIEKILTFRIPYYVGPL ARGK-- ^■SEFAWLNR— -KSDEKIRPWNFDEMVDKET 486

WP ^"049533112 420 HAILRRQEEHYPFLKE- -NQD KIEKILTFRIPYYVGPL ARKG-- SRFAWAEY— -KADEKITPWNFDDILDKEK 486

WP ^"029090905 404 VAILENQATYYPFLLE- -QKD NIHKLLTFRI PYYVGPL ADQKd- SEFAWMVR— -KQAGKITPFNFEEMVDIDA 471

WP ^"006506696 430 IKIIDNQAEYYPILKE- -KRE QLLSILTFRIPYYFGPL ETSEh- AWIKRlegKENQRILPWNYQDIVDVDA 498

AIT42264 420 HAILRRQEDFYPFLKD- -NRE KIEKILTFRIPYYVGPL ARG-n- SRFAWMTR— -KSEETITPWNFEEWDKGA 486

WP 034440723 426 TAVLDQQEKHYSFLKE- -NRD KI I SLLTFRI PYYVGPL AKGE-- SRFAWLER—sNSEEKIKPWNFDKIVDIDK 493

AKQ21048 420 HAILRRQEDFYPFLKD- -NRE KIEKILTFRIPYYVGPL ARG-n- ^■SRFAWMTR— -KSEETITPWNFEEWDKGA 486

WP 004636532 421 QAILDRQSQYYPFLAE- -NRD KIESLVTFRI PYYVGPL TVSDq- SEFAWMER— -QSDEPIRPWNFDEIVNKER 488

WP ^"002364836 428 QAIIHRQAAYYPFLKE- -NQE KIEQLVTFRI PYYVGPL SKGDa- STFAWLKR— -QSEEPIRPWNLQETVDLDQ 495

WP ^"016631044 379 QAIIHRQAAYYPFLKE- -NQE KIEQLVTFRI PYYVGPL SKGDa- STFAWLKR— -QSEEPIRPWNLQETVDLDQ 446

EMS75795 163 KAIIERQKPYYPSLEE- -ARD KMIRLLTFRI PYYVGPL AQGEetSSFAWLER— -KTPEKVTPWNATEVIDYSA 231

WP 002373311 428 QAIIHRQAAYYPFLKE- -NQE KIEQLVTFRI PYYVGPL SKGDa- ^■STFAWLKR— -QSEEPIRPWNLQETVDLDQ 495

WP ^"002378009 428 QAIIHRQAAYYPFLKE- -NQE KIEQLVTFRI PYYVGPL SKGDa- NTFAWLKR— -QSEEPIRPWNLQETVDLDQ 495

WP ^"002407324 428 QAIIHRQAAYYPFLKE- -NQE KIEQLVTFRI PYYVGPL SKGDa- ^■STFAWLKR— -QSEEPIRPWNLQETVDLDQ 495

WP ^"002413717 428 QAIIHRQAAYYPFLKE- -NQE KIEQLVTFRI PYYVGPL SKGDa- ^■STFAWLKR— -QSEEPIRPWNLQETVDLDQ 495

WP ^"010775580 430 QAIIHRQAAYYPFLKE- -NQK KIEQLVTFRI PYYVGPL SKGDa- ^■STFAWLKR— -QSEEPIRPWNLQETVDLDQ 497

WP ^"010818269 428 QAIIHRQAAYYPFLKE- -NQE KIEQLVTFRI PYYVGPL SKGDa- ^■STFAWLKR— -QSEEPIRPWNLQETVDLDQ 495

WP 010824395 428 QAIIHRQAAYYPFLKE--NQE KIEQLVTFRIPYYVGPL SKGDa-STFAWLKR QSEEPIRPWNLQETVDLDQ 495

WP ^"016622645 428 QAIIHRQAAYYPFLKE- -NQE KIEQLVTFRIPYYVGPL SKGDa-STFAWLKR QSEEPIRPWNLQETVDLDQ 495

WP ^"033624816 428 QAIIHRQAAYYPFLKE- -NQK KIEQLVTFRIPYYVGPL SKGDa-STFAWLKR QSEEPIRPWNLQETVDLDQ 495

WP ^"033625576 428 QAIIHRQAAYYPFLKE- -NQE KIEQLVTFRIPYYVGPL SKGDa-STFAWLKR QNEKPIRPWNLQETVDLDQ 495

WP ^"033789179 428 QAIIHRQAAYYPFLKE- -NQK KIEQLVTFRIPYYVGPL SKGDa-STFAWLKR QSEEPIRPWNLQETVDLDQ 495

WP ^"002310644 424 RAIIANQKKHYPFLKE- -EQE KLESLLTFKIPYYVGPL AKKQenSPFAWLIR KSEEKIKPWNLPEIVDMEG 492

WP ^"002312694 425 RAIIANQKKHYPFLKE- -EQE KLESLLTFKIPYYVGPL AKKQenSPFAWLIR KSEEKIKPWNLPEIVDMEG 493

WP ^"002314015 425 RAIIANQKKHYPFLKE- -EQE KLESLLTFKIPYYVGPL AKKQenSPFAWLIR KSEEKIKPWNLPEIVDMEG 493

WP ^"002320716 425 RAIIANQKKHYPFLKE- -EQE KLESLLTFKIPYYVGPL AKKQenSPFAWLIR KSEEKIKPWNLPEIVDMEG 493

WP ^"002330729 424 RAIIANQKKHYPFLKE- -EQE KLESLLTFKIPYYVGPL AKKQenSPFAWLIR KSEEKIKPWNLPEIVDMEG 492

WP ^"002335161 425 RAIIANQKKHYPFLKE- -EQE KLESLLTFKIPYYVGPL AKKQenSPFAWLIR KSEEKIKPWNLPEIVDMEG 493

WP ^"002345439 425 RAIIANQKKHYPFLKE- -EQE KLESLLTFKIPYYVGPL AKKQenSPFAWLIR KSEEKIKPWNLPEIVDMEG 493

WP ^"034867970 418 KAIIDQQKQHYPFLEE- -AGP KIIALFKFRIPYYVGPL AKEQeaSSFAWIER KTAEKINPWNFSEWDIEK 486

WP ^"047937432 425 RAIIANQKKHYPFLKE- -EQE KLESLLTFKIPYYVGPL AKKQenSPFAWLIR KSEEKIKPWNLPEIVDMEG 493

WP ^"010720994 418 KAIIDQQKQHYPFLEE- -AGP KIIALFKFRIPYYVGPL AKEQeaSSFAWIER KTAEKINPWNFSEWDIEK 486

WP ^"010737004 418 KAIIDQQKQHYPFLEE- -AGP KIIALFKFRIPYYVGPL AKEQeaSSFAWIER KTAEKINPWNFSEWDIEK 486

WP ^"034700478 418 KAIIDQQKQHYPFLEE- -AGP KIIALFKFRIPYYVGPL AKEQeaSSFAWIER KTAEKINPWNFSEWDIEK 486

WP ^"007209003 422 RAILRKQEKYYSFLKE- -NHE KIEQIFKVRIPYYVGPL AKHNeqSRFAWNIR KSDEPIRPWNMNDWDENA 490

WP ^"023519017 418 REIMDRQKRFYPFLKG- -AQG KIEKLLTFRIPYYVGPL AQEGq-SPFAWIKR KSPSQITPWNFAEWDKEN 485

WP ^"010770040 423 EAIIQKQATYYPFLAD- -NKE EMKQLVTFRIPYYVGPL ADGN—SPFAWLER ISSEPIRPGNLAEWDIKK 489

WP ^"048604708 419 KAILHHQAMYYPFLQE- -KFS NFVDLLTFRIPYYVGPL ANGN—SRFSWLSR KSDEPIRPWNLAEWDLSK 485

WP ^"010750235 418 KAIIDQQKQYYPFLEK- -SKE KMIQLLTFRIPYYVGPL AQDKetSSFAWLER KTTEKIKPWNAKDVIDYGA 486

AII16583 459 HAILRRQEDFYPFLKD- -NRE KIEKILTFRIPYYVGPL ARG-n-SRFAWMTR KSEETITPWNFEEWDKGA 525

WP 029073316 436 NKILENQSVYYSDLKD- -NED KIRSILTFRIPYYFGPL ITKDr—QFDWIIKkegKENERILPWNANEIVDVDK 506

WP ^"031589969 436 NKILENQSVYYSDLKD- -NED KIRSILTFRIPYYFGPL ITKDr—QFDWIIKkegKENERILPWNANEIVDVDK 506

KDA45870 418 VAIVENQGKYYPFLRE- -NKD KFEKILNFRIPYYVGPL ARGN—SKFAWLTR—a-GEGKITPYNFDEMIDKET 484

WP 039099354 426 DRIIENQQQYYPWLAE- 1NPN KLDELVAFRVPYYVGPL QQQSsdAKFAWMIR KAEGQITPWNFDDKVDRQA 509

AKP02966 416 EKIIDNQSQYYPFLKE- -NKE KLLSILSFRIPYYVGPL -QSSekNPFAWMER KSNGHARPWNFDEIVDREK 483

WP 010991369 426 EAILHQQAKYYPFLKE- -NYD KIKSLVTFRIPYFVGPL ANGQ—SEFAWLTR KADGEIRPWNIEEKVDFGK 492

WP ^"033838504 426 EAILHQQAKYYPFLKE- -NYD KIKSLVTFRIPYFVGPL ANGQ—SEFAWLTR KADGEIRPWNIEEKVDFGK 492

EHN60060 429 EAILHQQAKYYPFLKE- -NYD KIKSLVTFRIPYFVGPL ANGQ—SEFAWLTR KADGEIRPWNIEEKVDFGK 495

EFR89594 195 EAILHQQAKYYPFLKE- -NYD KIKSLVTFRIPYFVGPL ANGQ—SEFAWLTR KADGEIRPWNIEEKVDFGK 261

WP 038409211 426 EAILHQQAKYYPFLRK- -DYE KIRSLVTFRIPYFIGPL ANGQ—SDFAWLTR KADGEIRPWNIEEKVDFGK 492

EFR95520 45 EAILHQQAKYYPFLRK- -DYE KIRSLVTFRIPYFIGPL ANGQ—SDFAWLTR KADGEIRPWNIEEKVDFGK 111

WP 003723650 426 EAIIHQQAKYYPFLKE- -DYD KIKSLVTFRIPYFVGPL ANGQ—SEFAWLTR KADGEIRPWNIEEKVDFGK 492

WP ^"003727705 426 EAILHQQAKYYPFLRE- -GYD KIKSLVTFRIPYFVGPL ANGQ—SEFAWLTR KDDGEIRPWNIEEKVDFGK 492

WP ^"003730785 426 EAILHQQAKYYPFLRE- -GYD KIKSLVTFRIPYFVGPL ANGQ—SEFAWLTR KDDGEIRPWNIEEKVDFGK 492

WP ^"003733029 426 EAILHQQAKYYPFLRE- -DYE KIKSLVTFRIPYFVGPL AKGQ—SEFAWLTR KADGEIRPWNIEEKVDFGK 492

WP ^"003739838 426 EAILHQQAKYYPFLKE- -AYD KIKSLVTFRIPYFVGPL ANGQ—SDFAWLTR KADGEIRPWNIEEKVDFGK 492

WP 014601172 426 EAIIHQQAKYYPFLRE--DYE KIKSLVTFRIPYFVGPL AKGQ—SEFAWLTR KADGEIRPWNIEEKVDFGK 492

WP 023548323 426 EAILHQQAKYYPFLRE- -DYE KIKSLVTFRIPYFVGPL AKGQ—SEFAWLTR KADGEIRPWNIEEKVDFGK 492

WP 031665337 426 EAIIHQQAKYYTFLKE- -DYD KIKSLVTFRIPYFVGPL ANGQ—SEFAWLTR KADGEIRPWNIEEKVDFGK 492

WP 031669209 426 EAILHQQAKYYPFLRE- -DYE KIKSLVTFRIPYFVGPL AKGQ—SEFAWLTR KADGEIRPWNIEEKVDFGK 492

WP 033920898 426 EAIIHQQAKYYPFLRE- -DYE KIKSLVTFRIPYFVGPL AKGQ—SEFAWLTR KADGEIRPWNIEEKVDFGK 492

AKI42028 429 EAIIHQQAKYYPFLRE- -DYE KIKSLVTFRIPYFVGPL AKGQ—SEFAWLTR KADGEIRPWNIEEKVDFGK 495

AKI50529 429 EAIIHQQAKYYPFLRE- -DYE KIKSLVTFRIPYFVGPL AKGQ—SEFAWLTR KADGEIRPWNIEEKVDFGK 495

EFR83390

WP 046323366 426 EAILHQQAKYYPFLKV- -DYE KIKSLVTFRIPYFVGPL ANGQ—SEFSWLTR KADGEIRPWNIEEKVDFGK 492

AKE81011 436 HAILRRQEDFYPFLKD- -NRE KIEKILTFRIPYYVGPL ARG-n-SRFAWMTR KSEETITPWNFEEWDKGA 502

CU082355 434 IKI IDNQAKYYPVLKE- -KRE QLLSILTFRIPYYFGPL ETSEh AWIKRlegKENQRILPWNYQDTVDVDA 502

WP 033162887 435 IQIIDNQSVYYPQLKE- -NRD KLISILEFRIPYYFGPL AHSE FAWIKKfedKQKERILPWNYDQIVDIDA 503

AGZ 01981 453 HAILRRQEDFYPFLKD- -NRE KIEKILTFRIPYYVGPL ARG-n-SRFAWMTR KSEETITPWNFEEWDKGA 519

AKA60242 420 HAILRRQEDFYPFLKD- -NRE KIEKILTFRIPYYVGPL ARG-n-SRFAWMTR KSEETITPWNFEEWDKGA 486

AKS40380 420 HAILRRQEDFYPFLKD- -NRE KIEKILTFRIPYYVGPL ARG-n-SRFAWMTR KSEETITPWNFEEWDKGA 486

4UN5 B 424 HAILRRQEDFYPFLKD- -NRE KIEKILTFRIPYYVGPL ARG-n-SRFAWMTR KSEETITPWNFEEWDKGA 490

WP 010922251 487 SAQSFIERMTNFDKNLPNEKVLPKHSLLYEYFTVYNELTKVKYVT--EGMRKPaFLSG[ QKKAIVDLLFK--TNR--KVTV 561

WP ^"039695303 490 SAEKFITRMTLNDLYLPEEKVLPKHSHVYETYAVYNELTKIKYVN- -EQGKES-FFDSNMKQEIFDHVFK- -ENR- ^■KVTK 563

WP ^"045635197 48 7 SAEDFINKMTNYDLYLPEEKVLPKHSLLYETFAVYNELTKVKFIA- -EGLRDYqFLDSGQKKQIVNQLFK- -ENR- ^■KVTE 561

5AXW A 230 —KEWYEMLMGHCTYFPEELRSVKYAYNADLYNALNDLNNLVITR- -DENEKLeYYE KFQIIENVFK- -QKK- ^■KPTL 299

WP 009880683 171 SAQSFIERMTNFDKNLPNEKVLPKHSLLYEYFTVYNELTKVKYVT- -EGMRKPaFLSGEQKKAIVDLLFK- -TNR- ^■KVTV 245

WP ^"010922251 48 7 SAQSFIERMTNFDKNLPNEKVLPKHSLLYEYFTVYNELTKVKYVT- -EGMRKPaFLSGEQKKAIVDLLFK- -TNR- ^■KVTV 561

WP ^"011054416 48 7 SAQSFIERMTNFDKNLPNEKVLPKHSLLYEYFTVYNELTKVKYVT- -EGMRKPaFLSGEQKKAIVDLLFK- -TNR- ^■KVTV 561

WP ^"011284745 48 7 SAQSFIERMTNFDKNLPNEKVLPKHSLLYEYFTVYNELTKVKYVT- -EGMRKPaFLSGEQKKAIVDLLFK- -TNR- ^■KVTV 561

WP ^"011285506 48 7 SAQSFIERMTNFDKNLPNEKVLPKHSLLYEYFTVYNELTKVKYVT- -EGMRKPaFLSGEQKKAIVDLLFK- -TNR- ^■KVTV 561

WP ^"011527619 48 7 SAQSFIERMTNFDKNLPNEKVLPKHSLLYEYFTVYNELTKVKYVT- -EGMRKPaFLSGEQKKAIVDLLFK- -TNR- ^■KVTV 561

WP ^"012560673 48 7 SAQSFIERMTNFDKNLPNEKVLPKHSLLYEYFTVYNELTKVKYVT- -EGMRKPaFLSGEQKKAIVDLLFK- -TNR- ^■KVTV 561

WP ^"014407541 48 7 SAQSFIERMTNFDKNLPNEKVLPKHSLLYEYFTVYNELTKVKYVT- -EGMRKPaFLSGEQKKAIVDLLFK- -TNR- ^■KVTV 561

WP ^"020905136 48 7 SAQSFIERMTNFDKNLPNEKVLPKHSLLYEYFTVYNELTKVKYVT- -EGMRKPaFLSGEQKKAIVDLLFK- -TNR- ^■KVTV 561

WP ^"023080005 48 7 SAQSFIERMTNFDKNLPNEKVLPKHSLLYEYFTVYNELTKVKYVT- -EGMRKPaFLSGEQKKAIVDLLFK- -TNR- ^■KVTV 561

WP ^"023610282 48 7 SAQSFIERMTNFDKNLPNEKVLPKHSLLYEYFTVYNELTKVKYVT- -EGMRKPaFLSGEQKKAIVDLLFK- -TNR- ^■KVTV 561

WP ^"030125963 48 7 SAQSFIERMTNFDKNLPNEKVLPKHSLLYEYFTVYNELTKVKYVT- -EGMRKPaFLSGEQKKAIVDLLFK- -TNR- ^■KVTV 561

WP ^"030126706 48 7 SAQSFIERMTNFDKNLPNEKVLPKHSLLYEYFTVYNELTKVKYVT- -EGMRKPaFLSGEQKKAIVDLLFK- -TNR- ^■KVTV 561

WP ^"031488318 48 7 SAQSFIERMTNFDKNLPNEKVLPKHSLLYEYFTVYNELTKVKYVT- -EGMRKPeFLSGEQKKAIVDLLFK- -TNR- ^■KVTV 561

WP ^"032460140 48 7 SAQSFIERMTNFDKNLPNEKVLPKHSLLYEYFTVYNELTKVKYVT- -EGMRKPaFLSGEQKKAIVDLLFK- -TNR- ^■KVTV 561

WP ^"032461047 48 7 SAQSFIERMTNFDKNLPNEKVLPKHSLLYEYFTVYNELTKVKYVT- -EGMRKPaFLSGEQKKAIVDLLFK- -TNR- ^■KVTV 561

WP ^"032462016 48 7 SAQSFIERMTNFDKNLPNEKVLPKHSLLYEYFTVYNELTKVKYVT- -EGMRKPaFLSGEQKKAIVDLLFK- -TNR- ^■KVTV 561

WP ^"032462936 48 7 SAQSFIERMTNFDKNLPNEKVLPKHSLLYEYFTVYNELTKVKYVT- -EGMRKPaFLSGEQKKAIVDLLFK- -TNR- ^■KVTV 561

WP ^"032464890 48 7 SAQSFIERMTNFDKNLPNEKVLPKHSLLYEYFTVYNELTKVKYVT- -EGMRKPaFLSGEQKKAIVDLLFK- -TNR- ^■KVTV 561

WP ^"033888930 312 SAQSFIERMTNFDKNLPNEKVLPKHSLLYEYFTVYNELTKVKYVT- -EGMRKPaFLSGEQKKAIVDLLFK- -TNR- ^■KVTV 386

WP ^"038431314 48 7 SAQSFIERMTNFDKNLPNEKVLPKHSLLYEYFTVYNELTKVKYVT- -EGMRKPaFLSGEQKKAIVDLLFK- -TNR- ^■KVTV 561

WP ^"038432938 48 7 SAQSFIERMTNFDKNLPNEKVLPKHSLLYEYFTVYNELTKVKYVT- -EGMRKPaFLSGEQKKAIVDLLFK- -TNR- ^■KVTV 561

WP ^"038434062 48 7 SAQSFIERMTNFDKNLPNEKVLPKHSLLYEYFTVYNELTKVKYVT- -EGMRKPaFLSGEQKKAIVDLLFK- -TNR- ^■KVTV 561

BAQ51233 398 SAQSFIERMTNFDKNLPNEKVLPKHSLLYEYFTVYNELTKVKYVT- -EGMRKPaFLSGEQKKAIVDLLFK- -TNR- ^■KVTV 472

KGE60162

KGE60856

WP 002989955 48 7 SAQSFIERMTNFDKNLPNEKVLPKHSLLYEYFTVYNELTKVKYVT- -EGMRKPaFLSGEQKKAIVDLLFK- -TNR- ^■KVTV 561

WP ^"003030002 48 7 SAEKFITRMTLNDLYLPEEKVLPKHSLLYETFTVYNELTKVKYVN- -EQGEAK-FFDANMKQEIFDHVFK- -ENR- ^■KVTK 560

WP ^"003065552 490 SAEKFITRMTLNDLYLPEEKVLPKHSHVYETYAVYNELTKIKYVN- -EQGKDS-FFDSNMKQEIFDHVFK- -ENR- ^■KVTK 563

WP ^"001040076 48 8 SAEAFIHRMTNNDLYLPEEKVLPKHSLIYEKFTVYNELTKVRFLA- -EGFKDFqFLNRKQKETIFNSLFK- -EKR- ^■KVTE 562

WP ^"001040078 48 8 SAEAFIHRMTNNDFYLPEEKVLPKHSLIYEKFTVYNELTKVRYKN- -EQGETY-FFDSNIKQEIFDGVFK- -EHR- ^■KVSK 561

WP ^"001040080 48 8 SAEAFIHRMTNNDFYLPEEKVLPKHSLIYEKFTVYNELTKVRYKN- -EQGETY-FFDSNIKQEIFDGVFK- -EHR- ^■KVSK 561

WP ^"001040081 48 8 SAEAFIHRMTNNDFYLPEEKVLPKHSLIYEKFTVYNELTKVRYKN- -EQGETY-FFDSNIKQEIFDGVFK- -EHR- ^■KVSK 561

WP ^"001040083 48 8 SAEAFIHRMTNNDFYLPEEKVLPKHSLIYEKFTVYNELTKVRYKN- -EQGETY-FFDSNIKQEIFDGVFK- -EHR- ^■KVSK 561

WP ^"001040085 48 8 SAEAFIHRMTNNDFYLPEEKVLPKHSLIYEKFTVYNELTKVRYKN- -EQGETY-FFDSNIKQEIFDGVFK- -EHR- ^■KVSK 561

WP 001040087 488 SAEAFIHRMTNNDFYLPEEKVLPKHSLIYEKFTVYNELTKVRYKN--EQGETY-FFDSNIKQEIFDGVFK--EHR-^■KVSK 561

WP 001040088 488 SAEAFIHRMTNNDFYLPEEKVLPKHSLIYEKFTVYNELTKVRYKN- -EQGETY-FFDSNIKQEIFDGVFK- -EHR- ^■KVSK 561

WP 001040089 488 SAEAFIHRMTNNDFYLPEEKVLPKHSLIYEKFTVYNELTKVRYKN- -EQGETY-FFDSNIKQEIFDGVFK- -EHR- ^■KVSK 561

WP 001040090 488 SAEAFIHRMTNNDFYLPEEKVLPKHSLIYEKFTVYNELTKVRYKN- -EQGETY-FFDSNIKQEIFDGVFK- -EHR- ^■KVSK 561

WP 001040091 488 SAEAFIHRMTNNDFYLPEEKVLPKHSLIYEKFTVYNELTKVRYKN- -EQGETY-FFDSNIKQEIFDGVFK- -EHR- ^■KVSK 561

WP 001040092 488 SAEAFIHRMTNNDLYLPEEKVLPKHSLIYEKFTVYNELTKVRYKN- -EQGETY-FFDSNVKQEIFDGVFK- -EHR- ^■KVSK 561

WP 001040094 488 SAEAFIHRMTNNDLYLPEEKVLPKHSLIYEKFTVYNELTKVRFLA- -EGFKDFqFLNRKQKETIFNSLFK- -EKR- ^■KVTE 562

WP 001040095 488 SAEAFIHRMTNNDLYLPEEKVLPKHSLIYEKFTVYNELTKVRFLA- -EGFKDFqFLNRKQKETIFNSLFK- -EKR- ^■KVTE 562

WP 001040096 488 SAEAFIHRMTNNDLYLPEEKVLPKHSLIYEKFTVYNELTKVRFLA- -EGFKDFqFLNRKQKETIFNSLFK- -EKR- ^■KVTE 562

WP 001040097 488 SAEAFIHRMTNNDLYLPEEKVLPKHSLIYEKFTVYNELTKVRFLA- -EGFKDFqFLNRKQKETIFNSLFK- -EKR- ^■KVTE 562

WP 001040098 488 SAEAFIHRMTNNDLYLPEEKVLPKHSLIYEKFTVYNELTKVRFLA- -EGFKDFqFLNRKQKETIFNSLFK- -EKR- ^■KVTE 562

WP 001040099 488 SAEAFIHRMTNNDLYLPEEKVLPKHSLIYEKFTVYNELTKVRFLA- -EGFKDFqFLNRKQKETIFNSLFK- -EKR- ^■KVTE 562

WP 001040100 488 SAEAFIHRMTNNDLYLPEEKVLPKHSLIYEKFTVYNELTKVRFLA- -EGFKDFqFLNRKQKETIFNSLFK- -EKR- ^■KVTE 562

WP 001040104 488 SAEAFIHRMTNNDFYLPEEKVLPKHSLIYEKFTVYNELTKVRYKN- -EQGETY-FFDSNIKQEIFDGVFK- -EHR- ^■KVSK 561

WP 001040105 488 SAEAFIHRMTNNDFYLPEEKVLPKHSLIYEKFTVYNELTKVRYKN- -EQGETY-FFDSNIKQEIFDGVFK- -EHR- ^■KVSK 561

WP 001040106 488 SAEAFIHRMTNNDLYLPEEKVLPKHSLIYEKFTVYNELTKVRYKN- -EQGETY-FFDSNIKQEIFDGVFK- -EHR- ^■KVSK 561

WP 001040107 488 SAEAFIHRMTNNDLYLPEEKVLPKHSLIYEKFTVYNELTKVRYKN- -EQGETY-FFDSNIKQEIFDGVFK- -EHR- ^■KVSK 561

WP 001040108 488 SAEAFIHRMTNNDLYLPEEKVLPKHSLIYEKFTVYNELTKVRYKN- -EQGETY-FFDSNIKQEIFDGVFK- -EHR- ^■KVSK 561

WP 001040109 488 SAEAFIHRMTNNDLYLPEEKVLPKHSLIYEKFTVYNELTKVRYKN- -EQGETY-FFDSNIKQEIFDGVFK- -EHR- ^■KVSK 561

WP 001040110 488 SAEAFIHRMTNNDLYLPEEKVLPKHSLIYEKFTVYNELTKVRYKN- -EQGETY-FFDSNIKQEIFDGVFK- -EHR- ^■KVSK 561

WP 015058523 488 SAEAFIHRMTNNDLYLPEEKVLPKHSLIYEKFTVYNELTKVRYKN- -EQGETY-FFDSNVKQEIFDGVFK- -EHR- ^■KVSK 561

WP 017643650 488 SAEAFIHRMTNNDLYLPEEKVLPKHSLIYEKFTVYNELTKVRFLA- -EGFKDFqFLNRKQKETIFNSLFK- -EKR- ^■KVTE 562

WP 017647151 488 SAEAFIHRMTNNDLYLPEEKVLPKHSLIYEKFTVYNELTKVRYKN- -EQGETY-FFDSNIKQEIFDGVFK- -EHR- ^■KVSK 561

WP 017648376 488 SAEAFIHRMTNNDLYLPEEKVLPKHSLIYEKFTVYNELTKVRYKN- -EQGETY-FFDSNIKQEIFDGVFK- -EHR- ^■KVSK 561

WP 017649527 488 SAEAFIHRMTNNDFYLPEEKVLPKHSLIYEKFTVYNELTKVRYKN- -EQGETY-FFDSNIKQEIFDGVFK- -EHR- ^■KVSK 561

WP 017771611 488 SAEAFIHRMTNNDLYLPEEKVLPKHSLIYEKFTVYNELTKVRYKN- -EQGETY-FFDSNIKQEIFDGVFK- -EHR- ^■KVSK 561

WP 017771984 488 SAEAFIHRMTNNDFYLPEEKVLPKHSLIYEKFTVYNELTKVRYKN- -EQGETY-FFDSNIKQEIFDGVFK- -EHR- ^■KVSK 561

CFQ25032 488 SAEAFIHRMTNNDFYLPEEKVLPKHSLIYEKFTVYNELTKVRYKN- -EQGETY-FFDSNIKQEIFDGVFK- -EHR- ^■KVSK 561

CFV16040 488 SAEAFIHRMTNNDFYLPEEKVLPKHSLIYEKFTVYNELTKVRYKN- -EQGETY-FFDSNIKQEIFDGVFK- -EHR- ^■KVSK 561

KLJ37842 488 SAEAFIHRMTNNDFYLPEEKVLPKHSLIYEKFTVYNELTKVRYKN- -EQGETY-FFDSNIKQEIFDGVFK- -EHR- ^■KVSK 561

KLJ72361 488 SAEAFIHRMTNNDFYLPEEKVLPKHSLIYEKFTVYNELTKVRYKN- -EQGETY-FFDSNIKQEIFDGVFK- -EHR- ^■KVSK 561

KLL20707 488 SAEAFIHRMTNNDFYLPEEKVLPKHSLIYEKFTVYNELTKVRYKN- -EQGETY-FFDSNIKQEIFDGVFK- -EHR- ^■KVSK 561

KLL42645 488 SAEAFIHRMTNNDLYLPEEKVLPKHSLIYEKFTVYNELTKVRYKN- -EQGETY-FFDSNIKQEIFDGVFK- -EHR- ^■KVSK 561

WP 047207273 488 SAEAFIHRMTNNDFYLPEEKVLPKHSLIYEKFTVYNELTKVRYKN- -EQGETY-FFDSNIKQEIFDGVFK- -EHR- ^■KVSK 561

WP 047209694 488 SAEAFIHRMTNNDLYLPEEKVLPKHSLIYEKFTVYNELTKVRFLA- -EGFKDFqFLNRKQKETIFNSLFK- -EKR- ^■KVTE 562

WP 050198062 488 SAEAFIHRMTNNDFYLPEEKVLPKHSLIYEKFTVYNELTKVRYKN- -EQGETY-FFDSNIKQEIFDGVFK- -EHR- ^■KVSK 561

WP 050201642 488 SAEAFIHRMTNNDFYLPEEKVLPKHSLIYEKFTVYNELTKVRYKN- -EQGETY-FFDSNIKQEIFDGVFK- -EHR- ^■KVSK 561

WP 050204027 488 SAEAFIHRMTNNDLYLPEEKVLPKHSLIYEKFTVYNELTKVRYKN- -EQGETY-FFDSNIKQEIFDGVFK- -EHR- ^■KVSK 561

WP 050881965 488 SAEAFIHRMTNNDFYLPEEKVLPKHSLIYEKFTVYNELTKVRYKN- -EQGETY-FFDSNIKQEIFDGVFK- -EHR- ^■KVSK 561

WP 050886065 488 SAEAFIHRMTNNDFYLPEEKVLPKHSLIYEKFTVYNELTKVRYKN--EQGETY-FFDSNIKQEIFDGVFK--EHR-^■KVSK 561

AHN30376 4 88 SAEAFIHRMTNNDLYLPEEKVLPKHSLIYEKFTVYNELTKVRYKN- -EQGETY-FFDSNVKQEIFDGVFK- -EHR- ^■KVSK 561

EA078426 4 88 SAEAFIHRMTNNDFYLPEEKVLPKHSLIYEKFTVYNELTKVRYKN- -EQGETY-FFDSNIKQEIFDGVFK- -EHR- ^■KVSK 561

CCW42055 4 88 SAEAFIHCMTNNDLYLPEEKVLPKHSLIYEKFTVYNELTKVRYKN- -EQGETY-FFDSNIKQEIFDGVFK- -EYR- ^■KVSK 561

WP 003041502 4 87 SAEKFITRMTLNDLYLPEEKVLPKHSLLYETFTVYNELTKVKYVN- -EQGEAK-FFDANMKQEIFDHVFK- -ENR- ^■KVTK 560

WP 037593752 4 88 SAEKFITRMTLNDLYLPEEKVLPKHSPLYETFTVYNELTKVKYVN- -EQGEAK-FFDTNMKQEIFDHVFK- -ENR- ^■KVTK 561

WP 049516684 4 88 SAEKFITRMTLNDLYLPEEKVLPKHSPLYETFTVYNELTKVKYVN- -EQGEAK-FFDTNMKQEIFDHVFK- -ENR- ^■KVTK 561

GAD46167 4 87 SAEKFITRMTLNDLYLPEEKVLPKHSPLYETFTVYNELTKVKYVN- -EQGEAK-FFDTNMKQEIFDHVFK- -ENR- ^■KVTK 560

WP 018363470 4 88 SAEKFITRMTLNDLYLPEEKVLPKHSHVYETFAVYNELTKVKYVN- -EQGKDS-FFDSNMKQEIFDHVFK- -ENR- ^■KVTK 561

WP 003043819 4 97 SAQSFIERMTNFDEQLPNKKVLPKHSLLYEYFTVYNELTKVKYVT- -ERMRKPeFLSGEQKKAIVDLLFK- -TNR- ^■KVTV 571

WP 006269658 4 87 SAEKFITRMTLNDLYLPEEKVLPKHSPLYEAFTVYNELTKVKYVN- -EQGEAK-FFDTNMKQEIFDHVFK- -ENR- ^■KVTK 560

WP 048800889 4 87 SAEKFITRMTLNDLYLPEEKVLPKHSLLYEIFTVYNELTKVKYVN- -EQGEAK-FFDANMKQEIFDHVFK- -ENP- ^■KVTK 560

WP 012767106 4 87 SAQSFIERMTNFDKNLPNEKVLPKHSLLYEYFTVYNELTKVKYVT- -EGMRKPeFLSGKQKEAIVDLLFK- -TNR- ^■KVTV 561

WP 014612333 4 87 SAQSFIERMTNFDKNLPNEKVLPKHSLLYEYFTVYNELTKVKYVT- -EGMRKPeFLSGKQKEAIVDLLFK- -TNR- ^■KVTV 561

WP 015017095 4 87 SAQSFIERMTNFDKNLPNEKVLPKHSLLYEYFTVYNELTKVKYVT- -EGMRKPeFLSGKQKEAIVDLLFK- -TNR- ^■KVTV 561

WP 015057649 4 87 SAQSFIERMTNFDKNLPNEKVLPKHSLLYEYFTVYNELTKVKYVT- -EGMRKPeFLSGKQKEAIVDLLFK- -TNR- ^■KVTV 561

WP 048327215 4 87 SAQSFIERMTNFDKNLPNEKVLPKHSLLYEYFTVYNELTKVKYVT- -EGMRKPeFLSGKQKEAIVDLLFK- -TNR- ^■KVTV 561

WP 049519324 4 87 SAQSFIERMTNFDKNLPNEKVLPKHSLLYEYFTVYNELTKVKYVT- -EGMRKPaFLSGEQKKAIVDLLFK- -TNR- ^■KVTV 561

WP 012515931 4 87 SAQIFIEKMTKNDLYLPNEKVLPKHSLLYETFTVYNELTKVKYAT- -EGMTRPqFLSADQKQAIVDLLFK- -TNR- ^■KVTV 561

WP 021320964 4 87 SAQIFIEKMTKNDLYLPNEKVLPKHSLLYETFTVYNELTKVKYAT- -EGMTRPqFLSADQKQAIVDLLFK- -TNR- ^■KVTV 561

WP 037581760 4 87 SAQIFIEKMTKNDLYLPNEKVLPKHSLLYETFTVYNELTKVKYAT- -EGMTRPqFLSADQKQAIVDLLFK- -TNR- ^■KVTV 561

WP 004232481 4 87 SAEKFITRMTLNDLYLPEEKVLPKHSYVYETFAVYNELTKIKYVN- -EQGKSF-FFDANMKQEI FDHVFK- -ENR- ^■KVTK 560

WP 009854540 4 88 SAEKFITRMTLNDLYLPEEKVLPKHSHVYETYAVYNELTKIKYVN- -EQGKES-FFDSNMKQEIFDHVFK- -ENR- ^■KVTK 561

WP 012962174 4 88 SAEKFITRMTLNDLYLPEEKVLPKHSLVYETYTVYNELTKVKYVN- -EQGKSN-FFDANMKQEI FEHVFK- -ENR- ^■KVTK 561

WP 039695303 4 90 SAEKFITRMTLNDLYLPEEKVLPKHSHVYETYAVYNELTKIKYVN- -EQGKES-FFDSNMKQEIFDHVFK- -ENR- ^■KVTK 563

WP 014334983 4 87 SAEKFITRMTLNDLYLPEEKVLPKHSHVYETFTVYNELTKIKYVN- -EQGESF-FFDANMKQEI FDHVFK- -ENR- ^■KVTK 560

WP 003099269 4 87 SARAFIERMTNFDTYLPEEKVLPKHSPLYEMFMVYNELTKVKYQT- -EGMKRPvFLSSEDKEEI LLFK- -KER- ^■KVTV 561

AHY15608 4 87 SARAFIERMTNFDTYLPEEKVLPKHSPLYEMFMVYNELTKVKYQT- -EGMKRPvFLSSEDKEEI LLFK- -KER- ^■KVTV 561

AHY17476 4 87 SARAFIERMTNFDTYLPEEKVLPKHSPLYEMFMVYNELTKVKYQT- -EGMKRPvFLSSEDKEEI LLFK- -KER- ^■KVTV 561 ESR09100

AGM98575 4 87 SARAFIERMTNFDTYLPEEKVLPKHSPLYEMFMVYNELTKVKYQT- -EGMKRPvFLSSEDKEEI LLFK- -KER- ^■KVTV 561

ALF27331 4 87 SAEAFINRMTNYDLYLPNQKVLPRHSLLYEKFTVYNELTKVKYKT- -EQGKTA-FFDANMKQEI FDGVFK- -VYR- ^■KVTK 560

WP 018372492 5 00 SASRFIERMTLHDLYLPDEKVLPRHSLIYEKYTVFNELTKVRFTP- -EGGKEV-YFSKTDKENIFDSLFK- -RYR- ^■KVTK 573

WP 045618028 4 88 SAEDFINKMTNYDLYLPEEKVLPKHSLLYETFAVYNELTKVKFIA- -EGLRDYqFLDSGQKQQIVTQLFK- -EKR- ^■KVTE 562

WP 045635197 4 87 SAEDFINKMTNYDLYLPEEKVLPKHSLLYETFAVYNELTKVKFIA- -EGLRDYqFLDSGQKKQI QLFK- -ENR- ^■KVTE 561

WP 002263549 4 87 SAEAFINRMTNYDLYLPNQKVLPKHSLLYEKFTVYNELTKVKYKT- -EQGKTA-FFDANMKQEI FDGVFK- -VYR- ^■KVTK 560

WP 002263887 4 87 SAEAFINRMTNYDLYLPNQKVLPKHSLLYEKFTVYNELIKVKYKT- -EQGKTA-FFDANMKQEI FDGVFK- -VYR- ^■KVTK 560

WP 002264920 4 87 SVEAFINRMTNYDLYLPNQKVLPKHSLLYEKFTVYNELTKVKYKT- -EQGKTA-FFDANMKQEI FDGVFK- -VYR- ^■KVTK 560

WP 002269043 4 87 SVEAFINRMTNYDLYLPNQKVLPKHSLLYEKFTVYNELTKVKYKT- -EQGKTA-FFDANMKQEIFDGVFK- -VYR- ^■KVTK 560

WP 002269448 487 SAEAFINRMTNYDLYLPNQKVLPKHSLLYEKFTVYNELTKVKYKT--EQGKTA- FFDANMKQEIFDGVFK--VYR-^■KVTK 560

WP ^"0022 71977 4 87 SAEAFINRMTNYDLYLPNQKVLPKHSLLYEKFTVYNELTKVKYKT- -EQGKTA- FFDANMKQEIFDGVFK- -VYR- ^■KVTK 560

WP ^"0022 72766 4 87 SAEAFINRMTNYDLYLPNQKVLPKHSLLYEKFTVYNELTKVKYKT- -EQGKTA- FFDANMKQEIFDGVFK- -VYR- ^■KVTK 560

WP ^"0022 73241 4 87 SAEAFINRMTNYDLYLPNQKVLPKHSLLYEKFTVYNELTKVKYKT- -EQGKTA- FFDANMKQEIFDGVFK- -VYR- ^■KVTK 560

WP ^"0022 75430 4 87 SAEAFINRMTNYDLYLPNQKVLPKHSLLYEKFTVYNELTKVKYKT- -EQGKTA- FFDANMKQEIFDGVFK- -VYR- ^■KVTK 560

WP ^"0022 76448 4 87 SAEAFINRMTNYDLYLPNQKVLPKHSLLYEKFTVYNELTKVKYKT- -EQGKTA- FFDANMKQEIFDGVFK- -VYR- ^■KVTK 560

WP ^"0022 77050 4 87 SAQAFIEHMTNNDLYLPNEKVLPKHSPLYEKYTVYNELTKIKYVT- -EIGEAK- FFDANLKQEIFDGLFK- -HER- ^■KVTK 560

WP ^"0022 77364 4 87 SAEAFINRMTNYDLYLPNQKVLPKHSLLYEKFTVYNELTKVKYKT- -EQGKTA- FFDANMKQEIFDGVFK- -VYR- ^■KVTK 560

WP ^"0022 79025 4 87 SAEAFINRMTNYDLYLPNQKVLPKHSLLYEKFTVYNELTKVKYKT- -EQGETA- FFDANMKQEIFDGVFK- -VYR- ^■KVTK 560

WP ^"0022 79859 4 87 SVEAFINRMTNYDLYLPNQKVLPKHSLLYEKFTVYNELTKVKYKT- -EQGKTA- FFDANMKQEIFDGVFK- -VYR- ^■KVTK 560

WP ^"0022 80230 4 87 SAEAFINRMTNYDLYLPNQKVLPKHSLLYEKFTVYNELTKVKYKT- -EQGKTA- FFDANMKQEIFDGVFK- -VYR- ^■KVTK 560

WP ^"0022 81696 4 87 SAEAFINRMTNYDLYLPNQKVLPKHSLLYEKFTVYNELTKVKYKT- -EQGKTA- FFDANMKQEIFDGVFK- -VYR- ^■KVTK 560

WP ^"0022 82247 4 87 SAQAFIEHMTNNDLYLPNEKVLPKHSPLYEKYTVYNELTKIKYVT- -EIGEAK- FFDANLKQEIFDGLFK- -HER- ^■KVTK 560

WP ^"0022 82906 4 87 SAEAFINRMTNYDLYLPNQKVLPKHSLLYEKFTVYNELTKVKYKT- -EQGKTA- FFDANMKQEIFDGVFK- -VYR- ^■KVTK 560

WP ^"0022 83846 4 87 SVEAFINRMTNYDLYLPNQKVLPKHSLLYEKFTVYNELTKVKYKT- -EQGKTA- FFDANMKQEIFDGVFK- -VYR- ^■KVTK 560

WP ^"0022 87255 4 87 SAEAFINRMTNYDLYLPNQKVLPKHSLLYEKFTVYNELTKVKYKT- -EQGKTA- FFDANMKQEIFDGVFK- -VYR- ^■KVTK 560

WP ^"0022 88990 4 87 SVEAFINRMTNYDLYLPNQKVLPKHSLLYEKFTVYNELTKVKYKT- -EQGKTA- FFDANMKQEIFDGVFK- -VYR- ^■KVTK 560

WP ^"0022 89641 4 87 SAEAFINRMTNYDLYLPNQKVLPKHSLLYEKFTVYNELTKVKYKT- -EQGKTA- FFDANMKQEIFDGVFK- -VYR- ^■KVTK 560

WP ^"0022 90427 4 87 SAEAFINRMTNYDLYLPNQKVLPKHSLLYEKFTVYNELTKVKYKT- -EQGKTA- FFDANMKQEIFDGVFK- -VYR- ^■KVTK 560

WP ^"0022 95753 4 87 SAEAFINRMTNYDLYLPNQKVLPKHSLLYEKFTVYNELTKVKYKT- -EQGKTA- FFDANMKQEIFDGVFK- -VYR- ^■KVTK 560

WP ^"0022 96423 4 87 SVEAFINRMTNYDLYLPNQKVLPKHSLLYEKFTVYNELTKVKYKT- -EQGKTA- FFDANMKQEIFDGVFK- -VYR- ^■KVTK 560

WP ^"0023 04487 4 97 SAEKFITRMTLNDLYLPEEKVLPKHSLLYETFTVYNELTKVKYVN- -EQGEAK- FFDANMKQEIFDHVFK- -ENR- ^■KVTK 570

WP ^"0023 05844 4 87 SAEAFINRMTNYDLYLPNQKVLPKHSLLYEKFTVYNELTKVKYKT- -EQGKTA- FFDANMKQEIFDGVFK- -VYR- ^■KVTK 560

WP ^"0023 07203 4 87 SVEAFINRMTNYDLYLPNQKVLPKHSLLYEKFTVYNELTKVKYKT- -EQGKTA- FFDANMKQEIFDGVFK- -VYR- ^■KVTK 560

WP ^"0023 10390 4 87 SAEAFINRMTNYDLYLPNQKVLPKHSLLYEKFTVYNELTKVKYKT- -EQGKTA- FFDANMKQEIFDGVFK- -VYR- ^■KVTK 560

WP ^"0023 52408 4 87 SAEAFINRMTNYDLYLPNQKVLPKHSLLYEKFTVYNELTKVKYKT- -EQGKTA- FFDANMKQEIFDGVFK- -VYR- ^■KVTK 560

WP ^"0129 97688 4 87 SAEAFINRMTNYDLYLPNQKVLPKHSLLYEKFTVYNELTKVKYKT- -EQGKTA- FFDANMKQEIFDGVFK- -VYR- ^■KVTK 560

WP ^"θ146 77909 4 87 SVEAFINRMTNYDLYLPNQKVLPKHSLLYEKFTVYNELTKVKYKT- -EQGKTA- FFDANMKQEIFDGVFK- -VYR- ^■KVTK 560

WP ^"0193 12892 4 87 SAEAFINRMTNYDLYLPNQKVLPKHSLLYEKFTVYNELTKVKYKT- -EQGKTA- FFDANMKQEIFDGVFK- -VYR- ^■KVTK 560

WP ^"0193 13659 4 87 SAEAFINRMTNYDLYLPNQKVLPKHSLLYEKFTVYNELTKVKYKT- -EQGKTA- FFDANMKQEIFDGVFK- -VYR- ^■KVTK 560

WP ^"0193 14093 4 87 SVEAFINRMTNYDLYLPNQKVLPKHSLLYEKFTVYNELTKVKYKT- -EQGKTA- FFDANMKQEIFDGVFK- -VYR- ^■KVTK 560

WP ^"0193 15370 4 87 SAEAFINRMTNYDLYLPNQKVLPKHSLLYEKFTVYNELTKVKYKT- -EQGKTA- FFDANMKQEIFDGVFK- -VYR- ^■KVTK 560

WP ^"0198 03776 4 87 SAEAFINRMTNYDLYLPNQKVLPKHSLLYEKFTVYNELTKVKYKT- -EQGKTA- FFDANMKQEIFDGVFK- -VYR- ^■KVTK 560

WP ^"0198 05234 4 87 SAEAFINRMTNYDLYLPNQKVLPKHSLLYEKFTVYNELTKVKYKT- -EQGKTA- FFDANMKQEIFDGVFK- -VYR- ^■KVTK 560

WP ^"0247 83594 4 87 SAEAFINRMTNYDLYLPNQKVLPKHSLLYEKFTVYNELTKVKYKT- -EQGKTA- FFDANMKQEIFDGVFK- -VYR- ^■KVTK 560

WP ^"0247 84288 4 87 SAQAFIEHMTNNDLYLPNEKVLPKHSPLYEKYTVYNELTKIKYVT- -EIGEAK- FFDANLKQEIFDGLFK- -HER- ^■KVTK 560

WP ^"0247 84666 4 87 SAEAFINRMTNYDLYLPNQKVLPKHSLLYEKFTVYNELTKVKYKT- -EQGKTA- FFDANMKQEIFDGVFK- -VYR- ^■KVTK 560

WP ^"0247 84894 4 87 SAEAFINRMTNYDLYLPNQKVLPKHSLLYEKFTVYNELTKVKYKT- -EQGKTA- FFDANMKQEIFDGVFK- -VYR- ^■KVTK 560

WP ^"0247 86433 4 87 SAQAFIEHMTNNDLYLPNEKVLPKHSPLYEKYTVYNELTKIKYVT- -EIGEAK- FFDANLKQEIFDGLFK- -HER- ^■KVTK 560

WP_049473442 487 SAEAFINRMTNYDLYLPNQKVLPKHSLLYEKFTVYNELTKVKYKT EQGKTA-FFDANMKQEIFDGVFK -VYR-^■KVTK 560 WP_049474547 487 SAEAFINRMTNYDLYLPNQKVLPKHSLLYEKFTVYNELTKVKYKT EQGKTA-FFDANMKQEIFDGVFK -VYR- ^■KVTK 560 EMC03581 480 SAEAFINRMTNYDLYLPNQKVLPKHSLLYEKFTVYNELTKVKYKT EQGKTA-FFDANMKQEIFDGVFK -VYR- ^■KVTK 553 WP_00 0428612 488 SAESFINKMTNYDLYLPEEKVLPKHSLLYETFAVYNELTKVKFIA EGLRDYqFLDSRQKKDIFYTLFK eDKR- ^■KVTE 564 WP_000428613 488 SAEDFINKMTNYDLYLPEEKVLPKHSLLYETFAVYNELTKVKFIA EGLRDYqFLDSGQKKQIVTQLFK -EKR- ^■KVTE 562 WP_049523028 487 SAEDFIHRMTNYDLYLPEEKVLPKHSLLYETFTVYNELTKVKYIA EGMKDYqFLDSGQKKQI QLFK -EKR- ^■KVTE 561 WP_003107102 456 SAKVFIERMTNFDTYLPEEKVLPKHSLLYEMFTVYNELTKVKYQA EGMRKPeFLSSEEKIEIVSNLFK -TER- ^■KVTV 530 WP_054279288 489 SAQAFIERMTNFDEYLPQEKVLPKHSLTYEYFTVYNELTKVKYVT EGMTKPeFLSAGQKEQIVELLFK -KYR- ^■KVTV 563 WP_049531101 488 SAEAFINKMTNYDLYLPEEKVLPKHSLLYETFAVYNELTKVKFIA EGLRDYqFLDSGQKKKIINQLFK -EKR- ^■KVTE 562 WP_049538452 488 SAEDFINKMTNYDLYLPEEKVLPKHSLLYETFAVYNELTKVKFIA EGLRDYqFLDSGQKKQI QLFK -EKR- ^■KVTE 562 WP_049549711 488 SAEDFINKMTNYDLYLPEEKVLPKHSLLYETFAVYNELTKVKFIA EGLRDYqFLDSGQKKQI QLFK -EKR- ^■KVTE 562 WP_007896501 490 SAQAFIEGMTNYDTYLPEEKVLPKHSPLYEMFTVYNELTKVKYIA ENMTKP1YLSAEQKEAIIDHLFK -QTR- ^■KVTV 564 EFR44625 442 SAQAFIEGMTNYDTYLPEEKVLPKHSPLYEMFTVYNELTKVKYIA ENMTKP1YLSAEQKEAIIDHLFK -QTR- ^■KVTV 516 WP_00 2897477 487 SAEDFIHRMTNYDLYLPEEKVLPKHSLLYETFAVYNELTKVKFIA EGLRDYqFLDSGQKKQIWQLFK -EKR- ^■KVTE 561 WP_002906454 487 SAEDFINKMTNYDLYLPEEKVLPKHSLLYETFAVYNELTKVKFIA EGLRDYqFLDSGQKKQIWQLFK -DKR- ^■KVTE 561 WP_009729476 488 SAEDFINKMTNYDLYLPEEKVLPKHSLLYETFAVYNELTKVKFIA EGLRDYqFLDSGQKKQIVTQLFK -EKR- ^■KVTE 562 CQR24647 488 SAQAFIERMTNNDLYLPDQKVLPKHSLLYQKFAVYNELTKIKYVT ETGEAR-LFDVFLKKEIFDGLFK -KER- ^■KVTK 561 WP_00 0066813 488 SAEDFINKMTNYDLYLPEEKVLPKHSLLYETFAVYNELTKVKFIA EGLTRYqFLDKKQKKDIFDTFFK eNKR- ^■KVTE 564 WP_009754323 488 SAESFINKMTNYDLYLPEEKVLPKHSLLYETFAVYNELTKVKFIA EGLRDYqFFDSGQKKQIWQLFK -EKR- ^■KVTE 562 WP_044674937 4i Ϊ7 SAENFITRMTNYDQYLPDQKVLPKHSLLYEKFAVYNELTKVKFIA EGMRDYqFLDSGQKKDIVKTLFK -TKR- ^■KVTA 561 WP_044676715 4iΪ7 SAENFITRMTNYDQYLPDQKVLPKHSLLYEKFAVYNELTKVRYVT EQGKSF-FFDANMKQEI FDGVFK -VYR- ^■KVTK 560 WP_044680361 4iΪ7 SAENFITRMTNYDQYLPDQKVLPKHSLLYEKFAVYNELTKVRYVT EQGKSF-FFDANMKQEI FDGVFK -VYR- ^■KVTK 560 WP_044681799 4iΪ7 SAENFITRMTNYDQYLPDQKVLPKHSLLYEKFAVYNELTKVKFIA EGMRDYqFLDSGQKKDIVKTLFK -TKR- ^■KVTA 561 WP_049533112 4iΪ7 SAEKFITRMTLNDLYLPEEKVLPKHSLLYETFTVYNELTKVKY EQGEAK-FFDANMKQEI FDHVFK -ENR- ^■KVTK 560 WP_029090905 472 SSEAFIKRMTNKCTYLIHEDVIPKHSFSYAKFEVLNELNKIRLDG KP—IDIPLKKRIFEGLFL —EKtKVTQ 540 WP_006506696 499 TAEGFIKRMRSYCTYFPDEEVLPKNSLIVSKYEVYNELNKIRVDD kLLEVDVKNDIYNELFM -KNK- ^■TVTE 567 AIT42264 487 SAQSFIERMTNFDKNLPNEKVLPKHSLLYEYFTVYNELTKVKYVT EGMRKPaFLSGEQKKAIVDLLFK -TNR- ^■KVTV 561 WP_03 4440723 494 SAELFIENLTSRDTYLPDEPVLPKRSLIYQKFTIFNELTKISYID ERGILQ-NFSSREKIAI FNDLFK —NKsKVTK 567 AKQ21048 487 SAQSFIERMTNFDKNLPNEKVLPKHSLLYEYFTVYNELTKVKYVT EGMRKPaFLSGEQKKAIVDLLFK -TNR- ^■KVTV 561 WP_00 4636532 489 SAEKFIERMTNMDTYLLEEKVLPKRSLLYQTFEVYNELTKVRYTN EQGKTE-KLNRQQKAEIIETLFK qKNR- ^■-VRE 562 WP_002364836 496 SATAFIERMTNFDTYLPSEKVLPKHSLLYEKFMVFNELTKISYTD DRGIKA-NFSGKEKEKIFDYLFK -TRR- ^■KVKK 569 WP_016631044 447 SATAFIERMTNFDTYLPSEKVLPKHSLLYEKFMVFNELTKISYTD DRGIKA-NFSGKEKEKIFDYLFK -TRR- ^■KVKK 520 EMS75795 232 SAMKFIQRMINYDTYLPTEKVLPKHSILYQKYTIFNELTKVAYKD ERGIKH-QFSSKEKREIFKELFQ -KQR- ^■KVTV 305 WP_00 2373311 496 SATAFIERMTNFDTYLPSEKVLPKHSLLYEKFMVFNELTKISYTD DRGIKA-NFSGKEKEKIFDYLFK -TRR- ^■KVKK 569 WP_002378009 496 SATAFIERMTNFDTYLPSEKVLPKHSLLYEKFMVFNELTKISYTD DRGIKA-NFSGKEKEKIFDYLFK -TRR- ^■KVKK 569 WP_002407324 496 SATAFIERMTNFDTYLPSEKVLPKHSLLYEKFMVFNELTKISYTD DRGIKA-NFSGKEKEKIFDYLFK -TRR- ^■KVKK 569 WP_002413717 496 SATAFIERMTNFDTYLPSEKVLPKHSLLYEKFMVFNELTKISYTD DRGIKA-NFSGKEKEKIFDYLFK -TRR- ^■KVKK 569 WP_010775580 498 SATAFIERMTNFDTYLPSEKVLPKHSLLYEKFMVFNELTKISYTD DRGIKA-NFSGKEKEKIFDYLFK -TRR- ^■KVKK 571 WP 010818269 496 SATAFIERMTNFDTYLPSEKVLPKHSLLYEKFMVFNELTKISYTD DRGIKA-NFSGKEKEKIFDYLFK -TRR- ^■KVKK 569

WP 010824395 496 SATAFIERMTNFDTYLPSEKVLPKHSLLYEKFMVFNELTKISYTD—DRGIKA-^■NFSGKEKEKIFDYLFK--TRR- KVKK 569

WP 016622645 496 SATAFIERMTNFDTYLPSEKVLPKHSLLYEKFMVFNELTKISYTD— DRGIKA- ^■NFSGKEKEKIFDYLFK- -TRR- ^■KVKK 569

WP 033624816 496 SATAFIERMTNFDTYLPSEKVLPKHSLLYEKFMVFNELTKISYTD— DRGIKA- ^■NFSGKEKEKIFDYLFK- -TRR- ^■KVKK 569

WP 033625576 496 SATAFIERMTNFDTYLPSEKVLPKHSLLYEKFMVFNELTKISYTD— DRGIKA- ^■NFSGKEKEKIFDYLFK- -TRR- ^■KVKK 569

WP 033789179 496 SATAFIERMTNFDTYLPSEKVLPKHSLLYEKFMVFNELTKISYTD— DRGIKA- ^■NFSGKEKEKIFDYLFK- -TRR- ^■KVKK 569

WP 002310644 493 SAVRFIERMINTDMYMPHNKVLPKNSLLYQKFSIYNELTKVRYQD— ERGQMN- ^■YFSSIEKKEIFHELFE- -KNR- ^■KVTK 566

WP 002312694 494 SAVRFIERMINTDMYMPHNKVLPKNSLLYQKFSIYNELTKVRYQD— ERGQMN- ^■YFSSIEKKEIFHELFE- -KNR- ^■KVTK 567

WP 002314015 494 SAVRFIERMNNTDMYIPHNKVLPKNSLLYQKFSIYNELTKVRYQD— ERGQMN- ^■YFSSIEKKEIFHELFE- -KNR- ^■KVTK 567

WP 002320716 494 SAVRFIERMINTDMYIPHNKVLPKNSLLYQKFSIYNELTKVRYQD— ERGQMN- ^■YFSSIEKKEIFHELFE- -KNR- ^■KVTK 567

WP 002330729 493 SAVRFIERMINTDMYIPHNKVLPKNSLLYQKFSIYNELTKVRYQD— ERGQMN- ^■YFSSIEKKEIFHELFE- -KNR- ^■KVTK 566

WP 002335161 494 SAVRFIERMINTDMYMPHNKVLPKNSLLYQKFSIYNELTKVRYQD— ERGQMN- ^■YFSSIEKKEIFHELFE- -KNR- ^■KVTK 567

WP 002345439 494 SAVRFIERMINTDMYIPHNKVLPKNSLLYQKFSIYNELTKVRYQD— ERGQMN- ^■YFSSIEKKEIFHELFE- -KNR- ^■KVTK 567

WP 034867970 487 SAMRFIQRMTKQDTYLPTEKVLPKNSLLYQKYMIFNELTKVSYKD— ERGVKQ- ^■YFSGDEKQQIFKQLFQ- -KERgKITV 561

WP 047937432 494 SAVRFIERMINTDMYMPHNKVLPKNSLLYQKFSIYNELTKVRYQD— ERGQMN- ^■YFSSIEKKEIFHELFE- -KNR- ^■KVTK 567

WP 010720994 487 SAMRFIQRMTKQDTYLPTEKVLPKNSLFYQKYMIFNELTKVSYKD— ERGVKQ- ^■YFSGDEKQQIFKQLFQ- -KERgKITV 561

WP 010737004 487 SAMRFIQRMTKQDTYLPTEKVLPKNSLLYQKYMIFNELTKVSYKD— ERGVKQ- ^■YFSGDEKQQIFKQLFQ- -KERgKITV 561

WP 034700478 487 SAMRFIQRMTKQDTYLPTEKVLPKNSLLYQKYMIFNELTKVSYKD— ERGVKQ- ^■YFSGDEKQQIFKQLFQ- -KERgKITV 561

WP 007209003 491 SAVAFIERMTIKDIYL-NENVLPRHSLIYEKFTVFNELTKVLYAD— DRGVFQ- ^■RFSAEEKEDIFEKLFK- -SER- ^■KVTK 563

WP 023519017 486 SAIEFIERMTNQDTYLPKEKVLPKQSLIYQRFMIFNELTKVSYTD— ERGKSH- ^■YFSSEQKRKIFNELFK- -QHP- ^■RVTE 559

WP 010770040 490 SATKFIERMTNFDTYLPTEKVLPKHSMIYEKYMVYNELTKVSYVD— ERGMNQ- ^■RFSGEEKKQIVEELFK- -QSR- ^■KVTK 563

WP 048604708 486 SAELFIERMTNFDLYLPSEKVLPKHSMLYEKYTVYNELTKVTYKD— EQGKVQ- ^■NFSSEEKERIFIDLFK- -QHR- ^■KVTK 559

WP 010750235 487 SATKFIQRMINYDTYLPTEKVLPKYSMLYQKYTIFNELTKVAYKD— DRGIKH- ^■QFSSEEKLRIFQELFK- -KQR- ^■RVTK 560

AII16583 526 SAQSFIERMTNFDKNLPNEKVLPKHSLLYEYFTVYNELTKVKYVT— EGMRKPaFLSGEQKKAIVDLLFK- -TNR- ^■KVTV 600

WP 029073316 507 TADEFIKRMRNFCTYFPDEPVLAKNSLTVSKYEVLNEINKLRIND— hLIKRDIKDKMLHTLFM- -DHK- ^■SISA 575

WP 031589969 507 TADEFIKRMRNFCTYFPDEPVMAKNSLTVSKYEVLNEINKLRIND— hLIKRDMKDKMLHTLFM- -DHK- ^■SISA 575

KDA45870 485 SAEDFIKRMTINDLYLPTEPVLPKHSLLYERYTIFNELAGVRYVT— ENGEAK- ^■YFDAQTKRSIFE-LFK1 —DR- ^■KVSE 557

WP 039099354 510 SANEFIKRMTTTDTYLLAEDVLPKQSLIYQRFEVLNELNGLKIDD— QPITTE- LKQAI FTDLFM- —QKt :SVTV 578

AKP02966 484 SSNKFIRRMTVTDSYLVGEPVLPKNSLIYQRYEVLNELNNIRITEnl KTNPTGsRLTVETKQHIYNELFK- -NYK- ^■KITV 560

WP 010991369 493 SAVDFIEKMTNKDTYLPKENVLPKHSLCYQKYLVYNELTKVRYIN— DQGKTS- ^■YFSGQEKEQIFNDLFK- -QKR- ^■KVKK 566

WP 033838504 493 SAVDFIEKMTNKDTYLPKENVLPKHSLCYQKYLVYNELTKVRYIN— DQGKTS- ^■YFSGQEKEQIFNDLFK- -QKR- ^■KVKK 566

EHN60060 496 SAVDFIEKMTNKDTYLPKENVLPKHSLCYQKYLVYNELTKVRYIN— DQGKTS- ^■YFSGQEKEQIFNDLFK- -QKR- ^■KVKK 569

EFR89594 262 SAVDFIEKMTNKDTYLPKENVLPKHSLCYQKYLVYNELTKVRYIN— DQGKTS- ^■YFSGQEKEQIFNDLFK- -QKR- ^■KVKK 335

WP 038409211 493 SAIDFIEKMTNKDTYLPKENVLPKHSLCYQKYMVYNELTKIRYID— DQGKTH- ^■HFSGQEKQQIFNGLFK- -QQR- ^■KVKK 566

EFR95520 112 SAIDFIEKMTNKDTYLPKENVLPKHSLCYQKYMVYNELTKIRYID— DQGKTH- ^■HFSGQEKQQIFNGLFK- -QQR- ^■KVKK 185

WP 003723650 493 SAVDFIEKMTNKDTYLPKENVLPKHSLCYQKYMVYNELTKIRYID— DQGKTN- ^■YFSGREKQQVFNDLFK- -QKR- ^■KVKK 566

WP 003727705 493 SAVDFIEKMTNKDTYLPKENVLPKHSLCYQKYMVYNELTKIRYID— DQGKTN- ^■YFSGREKQQIFNDLFK- -QKR- ^■KVKK 566

WP 003730785 493 SAVDFIEKMTNKDTYLPKENVLPKHSLCYQKYMVYNELTKIRYID— DQGKTN- ^■YFSGREKQQIFNDLFK- -QKR- ^■KVKK 566

WP 003733029 493 SAVDFIEKMTNKDTYLPKENVLPKHSLCYQKYMVYNELTKVRYID— DQGKTN- ^■YFSGQEKQQIFNDLFK- -QKR- ^■KVKK 566

WP 003739838 493 SAVDFIEKMTNKDTYLPKENVLPKHSLYYQKYMVYNELTKVRYID— DQGKTN- ^■YFSGQEKQQIFNDYFK- -QKR- ^■KVSK 566

WP_014601172 493 SAVDFIEKMTNKDTYLPKENVLPKHSLCYQKYMVYNELTKVRYID—DQGKTN-YFSGQEKQQI FNDLFK- QKR- KVKK 566 WP_02 3548323 493 SAVDFIEKMTNKDTYLPKENVLPKHSLCYQKYMVYNELTKIRYID—DQGKTN-YFSGQEKQQI FNDLFK- QKR- ^■KVKK 566 WP_03 1665337 493 SAVDFIEKMTNKDTYLPKENVLPKHSLCYQKYMVYNELTKVRYID—DQGKTN-YFSGQEKQQI FNDLFK- QKR- ^■KVKK 566 WP_03 1669209 493 SAVDFIEKMTNKDTYLPKENVLPKHSLCYQKYMVYNELTKVRYID—DQGKTN-YFSGQEKQQI FNDLFK- QKR- ^■KVKK 566 WP_03 3920898 493 SAVDFIEKMTNKDTYLPKENVLPKHSLCYQKYMVYNELTKIRYID—DQGKTN-YFSGQEKQQI FNDLFK- QKR- ^■KVKK 566 AKI42 028 496 SAVDFIEKMTNKDTYLPKENVLPKHSLCYQKYMVYNELTKVRYID—DQGKTN-YFSGQEKQQI FNDLFK- QKR- ^■KVKK 569 AKI50 529 496 SAVDFIEKMTNKDTYLPKENVLPKHSLCYQKYMVYNELTKIRYID—DQGKTN-YFSGQEKQQI FNDLFK- QKR- ^■KVKK 569 EFR83 390 1 IFNDLFK- QKR- ^■KVKK 14 WP_04 6323366 493 SAIDFIEKMTNKDTYLPKENVLPKHSMCYQKYMVYNELTKIRYTD—DQGKTH-YFSGQEKQQI FNDLFK- QKR- ^■KVKK 566 AKE81 Oil 503 SAQSFIERMTNFDKNLPNEKVLPKHSLLYEYFTVYNELTKVKYVT—EGMRKPaFLSGEQKKAIVDLLFK- TNR- ^■KVTV 577 CU082355 503 TAEGFIKRMRSYCTYFPDEEVLPKNSLIVSKYEVYNELNKIRVDD kLLEVDVKNDIYNELFM- KNK- ^■TVTE 571 WP_033162 7 504 TAEGFIERMKNTGTYFPDEPVMAKNSLTVSKFEVLNELNKIRING kLIAVETKKELLSDLFM- KNK- ^■TITD 572 AGZ01981 520 SAQSFIERMTNFDKNLPNEKVLPKHSLLYEYFTVYNELTKVKYVT—EGMRKPaFLSGEQKKAIVDLLFK- TNR- ^■KVTV 594 AKA60242 487 SAQSFIERMTNFDKNLPNEKVLPKHSLLYEYFTVYNELTKVKYVT—EGMRKPaFLSGEQKKAIVDLLFK- TNR- ^■KVTV 561 AKS40380 487 SAQSFIERMTNFDKNLPNEKVLPKHSLLYEYFTVYNELTKVKYVT—EGMRKPaFLSGEQKKAIVDLLFK- TNR- ^■KVTV 561 4UN5 491 SAQSFIERMTNFDKNLPNEKVLPKHSLLYEYFTVYNELTKVKYVT—EGMRKPaFLSGEQKKAIVDLLFK- TNR- ^■KVTV 565

WP 010922251 562 KQLKEDYFKK--IECFDSVEISGVEDR—-FNASLGTYHDLLKIIKDK DFLDNEENEDILEDIVLTLTLFEDREMIE 633

WP ^"039695303 564 EKLLNYLNKE- -FPEYRIKDLIGLDKEnkSFNASLGTYHDLKKIL-DK AFLDDKVNEEVIEDIIKTLTLFEDKDMIH 637

WP ^"045635197 562 KDIIHYLHN— -VDGYDGIELKGIEKQ— -FNASLSTYHDLLKIIKDK EFMDDAKNEAILENIVHTLTIFEDREMIK 632

5AXW A 300 KQIAKEIL e —EDIKGYRVTSTGKPe- —FTNLKVYHDIKDITARK ENAELLDQIAKILTIYQSSEDIQ 368

WP 009880683 246 KQLKEDYFKK- -IECFDSVEISGVEDR— -FNASLGTYHDLLKIIKDK DFLDNEENEDILEDIVLTLTLFEDREMIE 317

WP ^"010922251 562 KQLKEDYFKK- -IECFDSVEISGVEDR— -FNASLGTYHDLLKIIKDK DFLDNEENEDILEDIVLTLTLFEDREMIE 633

WP ^"011054416 562 KQLKEDYFKK- -IECFDSVEISGVEDR— -FNASLGTYHDLLKIIKDK DFLDNEENEDILEDIVLTLTLFEDREMIE 633

WP ^"011284745 562 KQLKEDYFKK- -IECFDSVEISGVEDR— -FNASLGTYHDLLKIIKDK DFLDNEENEDILEDIVLTLTLFEDREMIE 633

WP ^"011285506 562 KQLKEDYFKK- -IECFDSVEISGVEDR— -FNASLGTYHDLLKIIKDK DFLDNEENEDILEDIVLTLTLFEDREMIE 633

WP ^"011527619 562 KQLKEDYFKK- -IECFDSVEISGVEDR— -FNASLGTYHDLLKIIKDK DFLDNEENEDILEDIVLTLTLFEDREMIE 633

WP ^"012560673 562 KQLKEDYFKK- -IECFDSVEISGVEDR— -FNASLGTYHDLLKIIKDK DFLDNEENEDILEDIVLTLTLFEDREMIE 633

WP ^"014407541 562 KQLKEDYFKK- -IECFDSVEISGVEDR— -FNASLGAYHDLLKIIKDK DFLDNEENEDILEDIVLTLTLFEDRGMIE 633

WP ^"020905136 562 KQLKEDYFKK- -IECFDSVEISGVEDR— -FNASLGTYHDLLKIIKDK DFLDNEENEDILEDIVLTLTLFEDREMIE 633

WP ^"023080005 562 KQLKEDYFKK- -IECFDSVEISGVEDR— -FNTSLGTYHDLLKIIKDK DFLDNEENEDILEDIVLTLTLFEDKEMIE 633

WP ^"023610282 562 KQLKEDYFKK- -IECFDSVEISGVEDR— -FNTSLGTYHDLLKIIKDK DFLDNEENEDILEDIVLTLTLFEDKEMIE 633

WP ^"030125963 562 KQLKEDYFKK- -IECFDSVEISGVEDR— -FNASLGTYHDLLKIIKDK DFLDNEENEDILEDIVLTLTLFEDREMIE 633

WP ^"030126706 562 KQLKEDYFKK- -IECFDSVEISGVEDR— -FNASLGTYHDLLKIIKDK DFLDNEENEDILEDIVLTLTLFEDREMIE 633

WP ^"031488318 562 KQLKEDYFKK- -IECFDSVEISGVEDR— -FNASLGTYHDLLKIIKDK DFLDNEENEDILEDIVLTLTLFEDREMIE 633

WP ^"032460140 562 KQLKEDYFKK- -IECFDSVEISGVEDR— -FNASLGTYHDLLKIIKDK DFLDNEENEDILEDIVLTLTLFEDREMIE 633

WP ^"032461047 562 KQLKEDYFKK- -IECFDSVEISGVEDR— -FNASLGTYHDLLKIIKDK DFLDNEENEDILEDIVLTLTLFEDREMIE 633

WP ^"032462016 562 KQLKEDYFKK- -IECFDSVEISGVEDR— -FNASLGTYHDLLKIIKDK DFLDNEENEDILEDIVLTLTLFEDREMIE 633

WP ^"032462936 562 KQLKEDYFKK- -IECFDSVEISGVEDR— -FNASLGTYHDLLKIIKDK DFLDNEENEDILEDIVLTLTLFEDKEMIE 633

WP ^"032464890 562 KQLKEDYFKK- -IECFDSVEISGVEDR— -FNASLGTYHDLLKIIKDK DFLDNEENEDILEDIVLTLTLFEDREMIE 633

WP ^"033888930 387 KQLKEDYFKK- -IECFDSVEISGVEDR— -FNASLGTYHDLLKIIKDK DFLDNEENEDILEDIVLTLTLFEDREMIE 458

WP ^"038431314 562 KQLKEDYFKK- -IECFDSVEISGVEDR— -FNASLGTYHDLLKIIKDK DFLDNEENEDILEDIVLTLTLFEDREMIE 633

WP ^"038432938 562 KQLKEDYFKK- -IECFDSVEISGVEDR— -FNTSLGTYHDLLKIIKDK DFLDNEENEDILEDIVLTLTLFEDKEMIE 633

WP ^"038434062 562 KQLKEDYFKK- -IECFDSVEISGVEDR— -FNASLGTYHDLLKIIKDK DFLDNEENEDILEDIVLTLTLFEDREMIE 633

BAQ51233 473 KQLKEDYFKK- -IECFDSVEISGVEDR— -FNASLGTYHDLLKIIKDK DFLDNEENEDILEDIVLTLTLFEDREMIE 544

KGE60162

KGE60856

WP 002989955 562 KQLKEDYFKK- -IECFDSVEISGVEDR— -FNASLGTYHDLLKIIKDK DFLDNEENEDILEDIVLTLTLFEDREMIE 633

WP ^"003030002 561 DKLLNYLNKE- -FEEFRIVNLTGLDKEnkAFNSSLGTYHDLRKIL-DK SFLDDKANEKTIEDIIQTLTLFEDREMIR 634

WP ^"003065552 564 EKLLNYLNKE- -FPEYRIKDLIGLDKEnkSFNASLGTYHDLKKIL-DK AFLDDKVNEEVIEDIIKTLTLFEDKDMIH 637

WP ^"001040076 563 KDIISFLNK— -VDGYEGIAIKGIEKQ— -FNASLSTYHDLKKIL-GK DFLDNTDNELILEDIVQTLTLFEDREMIK 632

WP ^"001040078 562 KKLLDFLAKE- -YEEFRIVDVIGLDKEnkAFNASLGTYHDLEKIL-DK DFLDNPDNESILEDIVQTLTLFEDREMIK 635

WP ^"001040080 562 KKLLDFLAKE- -YEEFRIVDVIGLDKEnkAFNASLGTYHDLEKIL-DK DFLDNPDNESILEDIVQTLTLFEDREMIK 635

WP ^"001040081 562 KKLLDFLAKE- -YEEFRIVDVIGLDKEnkAFNASLGTYHDLEKIL-DK DFLDNPDNESILEDIVQTLTLFEDREMIK 635

WP ^"001040083 562 KKLLDFLAKE- -YEEFRIVDVIGLDKEnkAFNASLGTYHDLEKIL-DK DFLDNPDNESILEDIIQTLTLFEDREMIK 635

WP ^"001040085 562 KKLLDFLAKE- -YEEFRIVDVIGLDKEnkAFNASLGTYHDLEKIL-DK DFLDNPDNESILEDIVQTLTLFEDREMIK 635

WP 001040087 562 KKLLDFLAKE--YEEFRIVDVIGLDKEnkAFNASLGTYHDLEKIL-^■DK DFLDNPDNESILEDIVQTLTLFEDREMIK 635

WP ^"001040088 562 KKLLDFLAKE- -YEEFRIVDVIGLDKEnkAFNASLGTYHDLEKIL- ^■DK DFLDNPDNESILEDIVQTLTLFEDREMIK 635

WP ^"001040089 562 KKLLDFLAKE- -YEEFRIVDVIGLDKEnkAFNASLGTYHDLEKIL- ^■DK DFLDNPDNESILEDIVQTLTLFEDREMIK 635

WP ^"001040090 562 KKLLDFLAKE- -YEEFRIVDVIGLDKEnkAFNASLGTYHDLEKIL- ^■DK DFLDNPDNESILEDIVQTLTLFEDREMIK 635

WP ^"001040091 562 KKLLDFLAKE- -YEEFRIVDVIGLDKEnkAFNASLGTYHDLEKIL- ^■DK DFLDNPDNESILEDIVQTLTLFEDREMIK 635

WP ^"001040092 562 KQLLDFLAKE- -FEEFRIVDVTGLDKEnkAFNASLGTYHDLKKIL- ^■DK DFLDNPDNESILEDIVQTITLFEDREMIK 635

WP ^"001040094 563 KDIISFLNK— -VDGYEGIAIKGIEKQ FNASLSTYHDLKKIL- ^■GK DFLDNTDNELILEDIVQTLTLFEDREMIR 632

WP ^"001040095 563 KDIISFLNK— -VDGYEGIAIKGIEKQ FNASLSTYHDLKKIL- ^■GK DFLDNTDNELILEDIVQTLTLFEDREMIR 632

WP ^"001040096 563 KDIISFLNK— -VDGYEGIAIKGIEKQ FNASLSTYHDLKKIL- ^■GK DFLDNTDNELILEDIVQTLTLFEDREMIR 632

WP ^"001040097 563 KDIISFLNK— -VDGYEGIAIKGIEKQ FNASLSTYHDLKKIL- ^■GK DFLDNTDNELILEDIVQTLTLFEDREMIR 632

WP ^"001040098 563 KDIISFLNK— -VDGYEGIAIKGIEKQ FNASLSTYHDLKKIL- ^■GK DFLDNTDNELILEDIVQTLTLFEDREMIR 632

WP ^"001040099 563 KDIISFLNK— -VDGYEGIAIKGIEKQ FNASLSTYHDLKKIL- ^■GK DFLDNTDNELILEDIVQTLTLFEDREMIR 632

WP ^"001040100 563 KDIISFLNK— -VDGYEGIAIKGIEKQ FNASLSTYHDLKKIL- ^■GK DFLDNTDNELILEDIVQTLTLFEDREMIR 632

WP ^"001040104 562 KKLLDFLAKE- -YEEFRIVDVIGLDKEnkAFNASLGTYHDLEKIL- ^■DK DFLDNPDNESILEDIVQTLTLFEDREMIK 635

WP ^"001040105 562 KKLLDFLAKE- -YEEFRIVDVIGLDKEnkAFNASLGTYHDLEKIL- ^■DK DFLDNPDNESILEDIVQTLTLFEDREMIK 635

WP ^"001040106 562 KKLLDFLAKE- -YEEFRIVDVIGLDKEnkAFNASLGTYHDLKKIL- ^■DK DFLDNPDNESILEDIVQTLTLFEDREMIK 635

WP ^"001040107 562 KKLLDFLAKE- -YEEFRIVDVIGLDKEnkAFNASLGTYHDLKKIL- ^■DK DFLDNPDNESILEDIVQTLTLFEDREMIK 635

WP ^"001040108 562 KKLLDFLAKE- -YEEFRIVDVIGLDKEnkAFNASLGTYHDLKKIL- ^■DK DFLDNPDNESILEDIVQTLTLFEDREMIK 635

WP ^"001040109 562 KKLLDFLAKE- -YEEFRIVDVIGLDKEnkAFNASLGTYHDLKKIL- ^■DK DFLDNPDNESILEDIVQTLTLFEDREMIK 635

WP ^"001040110 562 KKLLDFLAKE- -YEEFRIVDVIGLDKEnkAFNASLGTYHDLKKIL- ^■DK DFLDNPDNESILEDIVQTLTLFEDREMIK 635

WP ^"015058523 562 KQLLDFLAKE- -FEEFRIVDVTGLDKEnkAFNASLGTYHDLKKIL- ^■DK DFLDNPDNESILEDIVQTITLFEDREMIK 635

WP ^"017643650 563 KDIISFLNK— -VDGYEGIAIKGIEKQ FNASLSTYHDLKKIL- ^■GK DFLDNTDNELILEDIVQTLTLFEDREMIR 632

WP ^"017647151 562 KKLLDFLAKE- -YEEFRIVDVIGLDKEnkAFNASLGTYHDLKKIL- ^■DK DFLDNPDNESILEDIVQTLTLFEDREMIK 635

WP ^"017648376 562 KKLLDFLAKE- -YEEFRIVDVIGLDKEnkAFNASLGTYHDLKKIL- ^■DK DFLDNPDNESILEDIVQTLTLFEDREMIK 635

WP ^"017649527 562 KKLLDFLAKE- -YEEFRIVDVIGLDKEnkAFNASLGTYHDLEKIL- ^■DK DFLDNPDNESILEDIVQTLTLFEDREMIK 635

WP ^"017771611 562 KKLLDFLAKE- -YEEFRIVDVIGLDKEnkAFNASLGTYHDLKKIL- ^■DK DFLDNPDNESILEDIVQTLTLFEDREMIK 635

WP ^"017771984 562 KKLLDFLAKE- -YEEFRIVDVIGLDKEnkAFNASLGTYHDLEKIL- ^■DK DFLDNPDNESILEDIVQTLTLFEDREMIK 635

CFQ25032 562 KKLLDFLAKE- -YEEFRIVDVIGLDKEnkAFNASLGTYHDLEKIL- ^■DK DFLDNPDNESILEDIVQTLTLFEDREMIK 635

CFV16040 562 KKLLDFLAKE- -YEEFRIVDVIGLDKEnkAFNASLGTYHDLEKIL- ^■DK DFLDNPDNESILEDIVQTLTLFEDREMIK 635

KLJ37842 562 KKLLDFLAKE- -YEEFRIVDVIGLDKEnkAFNASLGTYHDLEKIL- ^■DK DFLDNPDNESILEDIVQTLTLFEDREMIK 635

KLJ72361 562 KKLLDFLAKE- -YEEFRIVDVIGLDKEnkAFNASLGTYHDLEKIL- ^■DK DFLDNPDNESILEDIVQTLTLFEDREMIK 635

KLL20707 562 KKLLDFLAKE- -YEEFRIVDVIGLDKEnkAFNASLGTYHDLEKIL- ^■DK DFLDNPDNESILEDIVQTLTLFEDREMIK 635

KLL42645 562 KKLLDFLAKE- -YEEFRIVDVIGLDKEnkAFNASLGTYHDLKKIL- ^■DK DFLDNPDNESILEDIVQTLTLFEDREMIK 635

WP 047207273 562 KKLLDFLAKE- -YEEFRIVDVIGLDKEnkAFNASLGTYHDLEKIL- ^■DK DFLDNPDNESILEDIVQTLTLFEDREMIK 635

WP ^"047209694 563 KDIISFLNK— -VDGYEGIAIKGIEKQ FNASLSTYHDLKKIL- ^■GK DFLDNTDNELILEDIVQTLTLFEDREMIR 632

WP ^"050198062 562 KKLLDFLAKE- -YEEFRIVDVIGLDKEnkAFNASLGTYHDLEKIL- ^■DK DFLDNPDNESILEDIVQTLTLFEDREMIK 635

WP ^"050201642 562 KKLLDFLAKE- -YEEFRIVDVIGLDKEnkAFNASLGTYHDLEKIL- ^■DK DFLDNPDNESILEDIVQTLTLFEDREMIK 635

WP ^"050204027 562 KKLLDFLAKE- -YEEFRIVDVIGLDKEnkAFNASLGTYHDLKKIL- ^■DK DFLDNPDNESILEDIVQTLTLFEDREMIK 635

WP ^"050881965 562 KKLLDFLAKE- -YEEFRIVDVIGLDKEnkAFNASLGTYHDLEKIL- ^■DK DFLDNPDNESILEDIVQTLTLFEDREMIK 635

WP 050886065 562 KKLLDFLAKE—YEEFRIVDVIGLDKEnkAFNASLGTYHDLEKIL-^■DK DFLDNPDNESILEDIVQTLTLFEDREMIK 635

AHN30376 562 KQLLDFLAKE—FEEFRIVDVTGLDKEnkAFNAS LGTYHDLKKI L- ^■DK DFLDNPDNESILEDIVQTITLFEDREMIK 635

EA078426 562 KKLLDFLAKE—YEEFRIVDVIGLDKEnkAFNAS LGTYHDLEKI L- ^■DK DFLDNPDNESILEDIVQTLTLFEDREMIK 635

CCW42055 562 KQLLDFLAKE—FEEFRIVDVTGLDKEnkAFNAS LGTYHDLEKI L- ^■GK DFLDNPDNESILEDIVQTLTLFEDREMIK 635

WP 003041502 561 DKLLNYLNKE—FEEFRIVNLTGLDKEnkVFNSS LGTYHDLRKI L- ^■NK SFLDNKENAQIIEDIIQTLTLFEDREMIR 634

WP 037593752 562 DKLLNYLNKE—FEEFRIVNLTGLDKEnkAFNSS LGTYHDLRKI L- ^■DK SFLDDKANEKTIEDIIQTLTLFEDREMIR 635

WP 049516684 562 DKLLNYLNKE—FEEFRIVNLTGLDKEnkAFNAS LGTYHDLRKI L- ^■DK SFLDDKVNEKIIEDIIQTLTLFEDREMIR 635

GAD46167 561 DKLLNYLNKE—FEEFRIVNLTGLDKEnkAFNSS LGTYHDLRKI L- ^■DK SFLDDKANEKTIEDIIQTLTLFEDREMIR 634

WP 018363470 562 EKLLNYLDKE—FPEYRIQDLVGLDKEnkSFNAS LGTYHDLKKI L- ^■DK SFLDDKVNEEVIEDIIKTLTLFEDREMIQ 635

WP 003043819 572 KQLKEDYFKK—IECFDSVEIIGVEDR FNAS LGTYHDLLKI IKDK DFLDNEENEDILEDIVLTLTLFEDREMIE 643

WP 006269658 561 DKLLNYLNKE—FEEFRIVNLTGLDKEnkAFNSS LGTYHDLRKI L- ^■DK SFLDDKANEKTIEDIIQTLTLFEDREMIR 634

WP 048800889 561 DKLLNYLDKE—FDEFRIVDLTGLDKEnkAFNAS LGTYHDLRKI L- ^■DK SFLDDKANEKTIEDIIQTLTLFEDREMIR 634

WP 012767106 562 KQLKEDYFKK—IECFDSVEISGVEDR FNAS LGTYHDLLKI IKDK DFLDNEENEDILEDIVLTLTLFEDKEMIE 633

WP 014612333 562 KQLKEDYFKK—IECFDSVEISGVEDR FNAS LGTYHDLLKI IKDK DFLDNEENEDILEDIVLTLTLFEDKEMIE 633

WP 015017095 562 KQLKEDYFKK—IECFDSVEISGVEDR FNAS LGTYHDLLKI IKDK DFLDNEENEDILEDIVLTLTLFEDKEMIE 633

WP 015057649 562 KQLKEDYFKK—IECFDSVEISGVEDR FNAS LGTYHDLLKI IKDK DFLDNEENEDILEDIVLTLTLFEDKEMIE 633

WP 048327215 562 KQLKEDYFKK—IECFDSVEISGVEDR FNAS LGTYHDLLKI IKDK DFLDNEENEDILEDIVLTLTLFEDKEMIE 633

WP 049519324 562 KQLKEDYFKK—IECFDSVEISGVEDR FNAS LGTYHDLLKI IKDK DFLDNEENEDILEDIVLTLTLFEDKEMIE 633

WP 012515931 562 KQLKENYFKK—IECWDSVEITGVEDS FNAS LGTYHDLLKI IQDK DFLDNPDNQKIIEDIILTLTLFEDKKMIS 633

WP 021320964 562 KQLKENYFKK—IECWDSVEITGVEDS FNAS LGTYHDLLKI IQDK DFLDNPDNQKIIEDIILTLTLFEDKKMIS 633

WP 037581760 562 KQLKENYFKK—IECWDSVEITGVEDS FNAS LGTYHDLLKI IQDK DFLDNPDNQKIIEDIILTLTLFEDKKMIS 633

WP 004232481 561 AKLLSYLNNE—FEEFRINDLIGLDKDskSFNAS LGTYHDLKKI L- ^■DK SFLDDKTNEQIIEDIVLTLTLFEDRDMIH 634

WP 009854540 562 EKLLNYLNKE—FPEYRIKDLIGLDKEnkSFNAS LGTYHDLKKI L- ^■DK AFLDDKVNEEVIEDIIKTLTLFEDKDMIH 635

WP 012962174 562 DKFLNYLNKE—FPEYRIQDLIGLDKEnkSFNAS LGTYHDLKKI L- ^■DK SFLDDKTNETIIEDIIQTLTLFEDRDMIR 635

WP 039695303 564 EKLLNYLNKE—FPEYRIKDLIGLDKEnkSFNAS LGTYHDLKKI L- ^■DK AFLDDKVNEEVIEDIIKTLTLFEDKDMIH 637

WP 014334983 561 AKLLSYLNNE—FEEFRINDLIGLDKDskSFNAS LGTYHDLKKI L- ^■DK SFLDDKTNGQIIEDIVLTLTLFEDRDMIH 634

WP 003099269 562 KQLKEEYFSK—MKCFHTVTILGVEDR FNAS LGTYHDLLKI FKDK AFLDDEANQDILEEIVWTLTLFEDQAMIE 633

AHY15608 562 KQLKEEYFSK—MKCFHTVTILGVEDR FNAS LGTYHDLLKI FKDK AFLDDEANQDILEEIVWTLTLFEDQAMIE 633

AHY17476 562 KQLKEEYFSK—MKCFHTVTILGVEDR FNAS LGTYHDLLKI FKDK AFLDDEANQDILEEIVWTLTLFEDQAMIE 633

ESR09100

AGM98575 562 KQLKEEYFSK—MKCFHTVTILGVEDR FNASLGTYHDLLKI FKDK AFLDDEANQDILEEIVWTLTLFEDQAMIE 633

ALF27331 561 DKLMDFLEKE—FDEFRIVDLTGLDKEnkAFNASYGTYHDLRKIL-DK DFLDNSKNEKILEDIVLTLTLFEDREMIR 634

WP 018372492 574 RKLKDFIEKElgYGYIDIDNIKGVEEQ FNASYTTYQDLLKIIGDK EFLDNEENKDLLEEIIYILTVFEDRKMIE 647

WP 045618028 563 KDIIQYLHN VDSYDGIELKGIEKQ FNASLSTYHDLLKI IKDK EFMDDSKNEAILENIVHTLTIFEDREMIK 633

WP 045635197 562 KDIIHYLHN VDGYDGIELKGIEKQ FNASLSTYHDLLKI IKDK EFMDDAKNEAILENIVHTLTIFEDREMIK 632

WP 002263549 561 DKLMDFLEKE—FDEFRIVDLTGLDKEnkVFNASYGTYHDLCKIL-DK DFLDNSKNEKILEDIVLTLTLFEDREMIR 634

WP 002263887 561 DKLMDFLEKE—FDEFRIVDLTGLDKEnkVFNASYGTYHDLCKIL-DK DFLDNSKNEKILEDIVLTLTLFEDREMIR 634

WP 002264920 561 DKLMDFLEKE—FDEFRIVDLTGLDKEnkAFNASYGTYHDLRKIL-DK DFLDNSKNEKILEDIVLTLTLFEDREMIR 634

WP 002269043 561 DKLMDFLEKE—FDEFRIVDLTGLDKEnkAFNASYGTYHDLRKIL-DK DFLDNSKNEKILEDIVLTLTLFEDREMIR 634

WP 002269448 561 DKLMDFLEKE--FDEFRIVDLTGLDKEnkVFNASYGTYHDLCKIL--DK DFLDNSKNEKILEDIVLTLTLFEDREMIR 634

WP ^"0022 71977 561 DKLMDFLEKE- -FDEFRIVDLTGLDKEnkVFNASYGTYHDLCKIL- -DK DFLDNSKNEKILEDIVLTLTLFEDREMIR 634

WP ^"0022 72766 561 DKLMDFLEKE- -FDEFRIVDLTGLDKEnkVFNASYGTYHDLCKIL- -DK DFLDNSKNEKILEDIVLTLTLFEDREMIR 634

WP ^"0022 73241 561 DKLMDFLEKE- -FDEFRIVDLTGLDKEnkVFNASYGTYHDLCKIL- -DK DFLDNSKNEKILEDIVLTLTLFEDREMIR 634

WP ^"0022 75430 561 DKLMDFLEKE- -FDEFRIVDLTGLDKEnkAFNASYGTYHDLRKIL- -DK DFLDNSKNEKILEDIVLTLTLFEDREMIR 634

WP ^"0022 76448 561 DKLMDFLEKE- -FDEFRIVDLTGLDKEnkVFNASYGTYHDLCKIL- -DK DFLDNSKNEKILEDIVLTLTLFEDREMIR 634

WP ^"0022 77050 561 KKLRTFLDKN- -FDEFRIVDIQGLDKEteTFNASYATYQDLLKVi: KDK VFMDNPENAEILENIVLTLTLFEDREMIK 635

WP ^"0022 77364 561 DKLMDFLEKE- -FDEFRIVDLTGLDKEnkAFNASYGTYHDLRKIL- -DK DFLDNSKNEKILEDIVLTLTLFEDREMIR 634

WP ^"0022 79025 561 DKLMDFLEKE- -FDEFRIVDLTGLDKEnkAFNASYGTYHDLRKIL- -DK DFLDNSKNEKILEDIVLTLTLFEDREMIR 634

WP ^"0022 79859 561 DKLMDFLEKE- -FDEFRIVDLTGLDKEnkAFNASYGTYHDLRKIL- -DK DFLDNSKNEKILEDIVLTLTLFEDREMIR 634

WP ^"0022 80230 561 DKLMDFLEKE- -FDEFRIVDLTGLDKEnkVFNASYGTYHDLCKIL- -DK DFLDNSKNEKILEDIVLTLTLFEDREMIR 634

WP ^"0022 81696 561 DKLMDFLEKE- -FDEFRIVDLTGLDKEnkAFNASYGTYHDLRKIL- -DK DFLDNSKNEKILEDIVLTLTLFEDREMIR 634

WP ^"0022 82247 561 KKLRTFLDKN- -FDEFRIVDIQGLDKEteTFNASYATYQDLLKVi: KDK VFMDNPENAEILENIVLTLTLFEDREMIK 635

WP ^"0022 82906 561 DKLMDFLEKE- -FDEFRIVDLTGLDKEnkVFNASYGTYHDLCKIL- -DK DFLDNSKNEKILEDIVLTLTLFEDREMIR 634

WP ^"0022 83846 561 DKLMDFLEKE- -FDEFRIVDLTGLDKEnkAFNASYGTYHDLRKIL- -DK DFLDNSKNEKILEDIVLTLTLFEDREMIR 634

WP ^"0022 87255 561 DKLMDFLEKE- -FDEFRIVDLTGLDKEnkAFNASYGTYHDLRKIL- -DK DFLDNSKNEKILEDIVLTLTLFEDREMIR 634

WP ^"0022 88990 561 DKLMDFLEKE- -FDEFRIVDLTGLDKEnkAFNASYGTYHDLRKIL- -DK DFLDNSKNEKILEDIVLTLTLFEDREMIR 634

WP ^"0022 89641 561 DKLMDFLEKE- -FDEFRIVDLTGLDKEnkVFNASYGTYHDLCKIL- -DK DFLDNSKNEKILEDIVLTLTLFEDREMIR 634

WP ^"0022 90427 561 DKLMDFLEKE- -FDEFRIVDLTGLDKEnkAFNASYGTYHDLRKIL- -DK DFLDNSKNEKILEDIVLTLTLFEDREMIR 634

WP ^"0022 95753 561 DKLMDFLEKE- -FDEFRIVDLTGLDKEnkVFNASYGTYHDLCKIL- -DK DFLDNSKNEKILEDIVLTLTLFEDREMIR 634

WP ^"0022 96423 561 DKLMDFLEKE- -FDEFRIVDLTGLDKEnkAFNASYGTYHDLRKIL- -DK DFLDNSKNEKILEDIVLTLTLFEDREMIR 634

WP ^"0023 04487 571 DKLLNYLNKE- -FEEFRI LTGLDKEnkVFNSSLGTYHDLRKIL- -NK SFLDNKENEQIIEDIIQTLTLFEDREMIR 644

WP ^"0023 05844 561 DKLMDFLEKE- -FDEFRIVDLTGLDKEnkVFNASYGTYHDLCKIL- -DK DFLDNSKNEKILEDIVLTLTLFEDREMIR 634

WP ^"0023 07203 561 DKLMDFLEKE- -FDEFRIVDLTGLDKEnkAFNASYGTYHDLRKIL- -DK DFLDNSKNEKILEDIVLTLTLFEDREMIR 634

WP ^"0023 10390 561 DKLMDFLEKE- -FDEFRIVDLTGLDKEnkAFNASYGTYHDLRKIL- -DK DFLDNSKNEKILEDIVLTLTLFEDREMIR 634

WP ^"0023 52408 561 DKLMDFLEKE- -FDEFRIVDLTGLDKEnkAFNASYGTYHDLRKIL- -DK DFLDNSKNEKILEDIVLTLTLFEDREMIR 634

WP ^"0129 97688 561 DKLMDFLEKE- -FDEFRIVDLTGLDKEnkAFNASYGTYHDLRKIL- -DK DFLDNSKNEKILEDIVLTLTLFEDREMIR 634

WP ^"θ146 77909 561 DKLMDFLEKE- -FDEFRIVDLTGLDKEnkAFNASYGTYHDLRKIL- -DK DFLDNSKNEKILEDIVLTLTLFEDREMIR 634

WP ^"0193 12892 561 DKLMDFLEKE- -FDEFRIVDLTGLDKEnkAFNASYGTYHDLRKIL- -DK DFLDNSKNEKILEDIVLTLTLFEDREMIR 634

WP ^"0193 13659 561 DKLMDFLEKE- -FDEFRIVDLTGLDKEnkVFNASYGTYHDLCKIL- -DK DFLDNSKNEKILEDIVLTLTLFEDREMIR 634

WP ^"0193 14093 561 DKLMDFLEKE- -FDEFRIVDLTGLDKEnkAFNASYGTYHDLRKIL- -DK DFLDNSKNEKILEDIVLTLTLFEDREMIR 634

WP ^"0193 15370 561 DKLMDFLEKE- -FDEFRIVDLTGLDKEnkAFNASYGTYHDLRKIL- -DK DFLDNSKNEKILEDIVLTLTLFEDREMIR 634

WP ^"0198 03776 561 DKLMDFLEKE- -FDEFRIVDLTGLDKEnkVFNASYGTYHDLCKIL- -DK DFLDNSKNEKILEDIVLTLTLFEDREMIR 634

WP ^"0198 05234 561 DKLMDFLEKE- -FDEFRIVDLTGLDKEnkAFNASYGTYHDLRKIL- -DK DFLDNSKNEKILEDIVLTLTLFEDREMIR 634

WP ^"0247 83594 561 DKLMDFLEKE- -FDEFRIVDLTGLDKEnkVFNASYGTYHDLCKIL- -DK DFLDNSKNEKILEDIVLTLTLFEDREMIR 634

WP ^"0247 84288 561 KKLRTFLDKN- -FDEFRIVDIQGLDKEteTFNASYATYQDLLKVi: KDK VFMDNPENAEILENIVLTLTLFEDREMIK 635

WP ^"0247 84666 561 DKLMDFLEKE- -FDEFRIVDLTGLDKEnkAFNASYGTYHDLRKIL- -DK DFLDNSKNEKILEDIVLTLTLFEDREMIR 634

WP ^"0247 84894 561 DKLMDFLEKE- -FDEFRIVDLTGLDKEnkVFNASYGTYHDLCKIL- -DK DFLDNSKNEKILEDIVLTLTLFEDREMIR 634

WP ^"0247 86433 561 KKLRTFLDKN- -FDEFRIVDIQGLDKEteTFNASYATYQDLLKVi: KDK VFMDNPENAEILENIVLTLTLFEDREMIK 635

WP 049473442 561 DKLMDFLEKE—FDEFRIVDLTGLDKEnkVFNASYGTYHDLCKIL-DK DFLDNSKNEKILEDIVLTLTLFEDREMIR 634

WP 049474547 561 DKLMDFLEKE—FDEFRIVDLTGLDKEnkVFNASYGTYHDLCKIL-DK DFLDNSKNEKILEDIVLTLTLFEDREMIR 634

EMC03581 554 DKLMDFLEKE—FDEFRIVDLTGLDKEnkAFNASYGTYHDLRKIL-DK DFLDNSKNEKILEDIVLTLTLFEDREMIR 627

WP 000428612 565 KDIIQYLHT-- -VDGYDGIELKGIEKQ- -FNASLSTYHDLLKIIKDK EFMDDPNNEEILENIVHTLTIFEDREMIK 635

WP 000428613 563 KDIIQFLHN-- -VDGYDGIELKGIEKQ- -FNASLSTYHDLLKIIKDK EFMDDSKNEEILENIVHTLTIFEDREMIK 633

WP 049523028 562 KDIIHYLHN-- -VDGYDGIELKGIEKH- -FNSSLSTYHDLLKIIKDK EFMDDPKNEEIFENIVHTLTIFEDRVMIK 632

WP 003107102 531 KQLKENYFNK- -IRCLDSITISGVEDK- -FNASLGTYHDLLNI IKNQ KILDDEQNQDSLEDIVLTLTLFEDEKMIA 602

WP 054279288 564 KQLKEDFFSK—IECFDTVDISGVEDK- -FNASLGTYHDLLKIIKDK AFLDNSENENIIEDIILTLTLFEDKEMIA 635

WP 049531101 563 KDLIHYLHN VDGYDGIELKGIEKQ- -FNASLSTYHDLLKIIKDK RFMDEPKNQEILENIVHTLTIFEDREMIK 633

WP 049538452 563 KDIIQYLHN VDGYDGIELKGIEKQ- -FNASLSTYHDLLKIIKDK EFMDDSKNEEILENIVHTLTIFEDREMIK 633

WP 049549711 563 KDIIHYLHT VDGYDGIELKGIEKQ- -FNASLSTYHDLLKIIKDK EFMDDSKNEAILENIVHTLTIFEDREMIK 633

WP 007896501 565 KDLKEKYFSQ—IEGLENVDVTGVEGA- -FNASLGTYNDLLKIIKDK AFLDDEANAEILEEIVLILTLFQDEKLIE 636

EFR44625 517 KDLKEKYFSQ—IEGLENVDVTGVEGA- -FNASLGTYNDLLKIIKDK AFLDDEANAEILEEIVLILTLFQDEKLIE 588

WP 002897477 562 KDIIHYLHN VDGYDGIELKGIEKQ- -FNANLSTYHDLLKITKDK EFMDDPKNEEILENIVHTLTIFEDREMIK 632

WP 002906454 562 KDIIHYLHN VDGYDGIELKGIEKQ- -FNASLSTYHDLLKIIKDK EFMDNPKNGEILENIIHTLTIFEDREMIK 632

WP 009729476 563 KDIIQFLHN VDGYDGIELKGIEKQ- -FNASLSTYHDLLKIIKDK AFMDDAKNEAILENIVHTLTI FEDREMIK 633

CQR24647 562 KKILNFLDKN—FDEFRITDIQGLDNEtgNFNASYGTYHDLLKIIGDK EFMDSSDNVDVLEDIVLSLTLFEDREMIK 636

WP 000066813 565 KDIIHYLHN VDGYDGIELKGIEKQ FNASLSTYHDLLKIIKDK AFMDDSKNEEILENI IHTLTI FEDREMIK 635

WP 009754323 563 KDIIHYLHN VDGYDGIELKGIEKQ FNASLSTYHDLLKIIKDK EFMDNHKNQEILENIVHTLTI FEDREMIK 633

WP 044674937 562 KDIKAYL-EN—SNGYAGVELKGLEEQ FNASLPTYHDLLKILRDK AFIDAEENQEILEDIVLTLTLFEDREMIR 632

WP 044676715 561 EKLMDFLGKE—FDEFRIVDLLGLDKDnkSFNASLGTYHDLKKIV-SK DLLDNPENEDILENWLTLTLFEDREMIR 634

WP 044680361 561 EKLMDFLGKE—FDEFRIVDLLGLDKDnkSFNASLGTYHDLKKIV-SK DLLDNPENEDILENWLTLTLFEDREMIR 634

WP 044681799 562 KDIKAYL-EN—SNGYAGVELKGLEEQ FNASLPTYHDLLKILRDK AFIDAEENQEILEDIVLTLTLFEDREMIR 632

WP 049533112 561 DKLLNYLGKE—FDEFRIVDLTGLDKEnkVFNSSLGTYHDLRKIL-DK SFLDNKENEQIIEDIIQTLTLFEDREMIR 634

WP 029090905 541 TSLKKWLAEH EHMTVSWQGTQKEt-EFATSLQAFHRFVKI F-DR ETVSNPANEEMFEKIIYWSTVFEDKKIMR 612

WP 006506696 568 KKLKNWLVNNqcCS—KDAEIKGFQKEn-QFSTSLTPWIDFTNIFGKI DQSNFDLIENIIYDLTVFEDKKIMK 637

AIT42264 562 KQLKEDYFKK—IECFDSVEISGVEDR- --FNASLGTYHDLLKIIKDK DFLDNEENEDILEDIVLTLTLFEDREMIE 633

WP 034440723 568 NQLVKYIENK EQIIAPEIKGIEDS- --FNSNYSTYIDLSKIPDMK —LLEKDEDEILEEIIKILTIFEDRKMRK 637

AKQ21048 562 KQLKEDYFKK—IECFDSVEISGVEDR- --FNASLGTYHDLLKIIKDK DFLDNEENEDILEDIVLTLTLFEDREMIE 633

WP 004636532 563 KDIANYLEQ YGYVDGTDIKGVEDK- --FNASLSTYNDLAKIDGAK AYLDDPEYADVWEDIIKILTIFEDKAMRK 633

WP 002364836 570 KDIIQFYRNE—YN-TEIVTLSGLEED- -QFNASFSTYQDLLKCGLTR AELDHPDNAEKLEDIIKILTIFEDRQRIR 641

WP 016631044 521 KDIIQFYRNE—YN-TEIVTLSGLEED- -QFNASFSTYQDLLKCGLTR AELDHPDNAEKLEDIIKILTIFEDRQRIR 592

EMS75795 306 KKLQQFLSAN—YN-IEDAEILGVDKA- --FNSSYATYHDFLDLAKPN ELLEQPEMNAMFEDIVKILTI FEDREMIR 381

WP 002373311 570 KDIIQFYRNE -YN-TEIVTLSGLEED- -QFNASFSTYQDLLKCGLTR AELDHPDNAEKLEDIIKILTIFEDRQRIR 641

WP 002378009 570 KDIIQFYRNE YN-TEIVTLSGLEED- -QFNASFSTYQDLLKCGLTR AELDHPDNAEKLEDIIKILTIFEDRQRIR 641

WP 002407324 570 KDIIQFYRNE YN-TEIVTLSGLEED- -QFNASFSTYQDLLKCGLTR AELDHPDNAEKLEDIIKILTIFEDRQRIR 641

WP 002413717 570 KDIIQFYRNE YN-TEIVTLSGLEED- -QFNASFSTYQDLLKCGLTR AELDHPDNAEKLEDIIKILTIFEDRQRIR 641

WP 010775580 572 KDIIQFYRNE YN-TEIVTLSGLEED- -QFNASFSTYQDLLKCGLTR AELDHPDNAEKLEDIIKILTIFEDRQRIR 643

WP 010818269 570 KDIIQFYRNE YN-TEIVTLSGLEED- -QFNASFSTYQDLLKCGLTR AELDHPDNAEKLEDIIKILTIFEDRQRIR 641

WP 010824395 570 KDIIQFYRNE--YN--TEIVTLSGLEED--QFNASFSTYQDLLKCGLTR AELDHPDNAEKLEDIIKILTIFEDRQRIR 641

WP ^"016622645 570 KDIIQFYRNE- -YN- -TEIVTLSGLEED- -QFNASFSTYQDLLKCGLTR AELDHPDNAEKLEDIIKILTIFEDRQRIR 641

WP ^"033624816 570 KDIIQFYRNE- -YN- -TEIVTLSGLEED- -QFNASFSTYQDLLKCGLTR AELDHPDNAEKLEDIIKILTIFEDRQRIR 641

WP ^"033625576 570 KDIIQFYRNE- -YN- -TEIVTLSGLEED- -QFNASFSTYQDLLKCGLTR AELDHPDNAEKLEDIIKILTIFEDRQRIR 641

WP ^"033789179 570 KDIIQFYRNE- -YN- -TEIVTLSGLEED- -QFNASFSTYQDLLKCGLTR AELDHPDNAEKLEDIIKILTIFEDRQRIR 641

WP ^"002310644 567 KDLQEFLYLK- -YD- -IKHAELSGIEKA- —FNASYTTYHDFLTMSENK QWLEDPELASMFEEIIKTLTVFEDREMIK 641

WP ^"002312694 568 KDLQEFLYLK- -YD- -IKHAELSGIEKA- —FNASYTTYHDFLTMSENK QWLEDPELASMFEEIIKTLTVFEDREMIK 642

WP ^"002314015 568 KDLQEFLYLK- -YD- -IKHAELSGIEKA- —FNASYTTYHDFLTMSENK QWLEDPELASMFEEIIKTLTVFEDREMIK 642

WP ^"002320716 568 KDLQEFLYLK- -YD- -IKHAELSGIEKA- —FNASYTTYHDFLTMSENK QWLEDPELASMFEEIIKTLTVFEDREMIK 642

WP ^"002330729 567 KDLQEFLYLK- -YD- -IKHAELSGIEKA- —FNASYTTYHDFLTMSENK QWLEDPELASMFEEIIKTLTVFEDREMIK 641

WP ^"002335161 568 KDLQEFLYLK- -YD- -IKHAELSGIEKA- —FNASYTTYHDFLTMSENK QWLEDPELASMFEEIIKTLTVFEDREMIK 642

WP ^"002345439 568 KDLQEFLYLK- -YD- -IKHAELSGIEKA- —FNASYTTYHDFLTMSENK QWLEDPELASMFEEIIKTLTVFEDREMIK 642

WP ^"034867970 562 KKLQNFLYTH- -YH- -IENAQIFGIEKA- —FNASYSTYHDFMKLAKTN EWLEQPEMEPIFEDIVKILTIFEDRQMIK 637

WP ^"047937432 568 KDLQEFLYLK- -YD- -IKHAELSGIEKA- —FNASYTTYHDFLTMSENK QWLEDPELASMFEEIIKTLTVFEDREMIK 642

WP ^"010720994 562 KKLQNFLYTH- -YH- -IENAQIFGIEKA- —FNASYSTYHDFMKLAKTN EWLEQPEMEPIFEDIVKILTIFEDRQMIK 637

WP ^"010737004 562 KKLQNFLYTH- -YH- -IENAQIFGIEKA- —FNASYSTYHDFMKLAKTN EWLEQPEMEPIFEDIVKILTIFEDRQMIK 637

WP ^"034700478 562 KKLQNFLYTH- -YH- -IENAQIFGIEKA- —FNASYSTYHDFMKLAKTN EWLEQPEMEPIFEDIVKILTIFEDRQMIK 637

WP ^"007209003 564 KKLENYLRIE1 3ISSPSVKGIEEQ- —FNANFGTYLDLKKFDELH PYLDDEKYQDTLEEVIKVLTVFEDRSMIQ 634

WP ^"023519017 560 KQLRKFLELN- -EQ- -IDSTEIKGIETS- —FNASYSTYHDLLKLS TLLDDPDMTTMFEEIIKILTIFEDREMIR 631

WP ^"010770040 564 KLLEKFLSNE- -FG- -LVDVAIKGIE-T- -SFNAGYGTYHDFLKIGITR EQLDKEENSETLEEIVKILTVFEDRKMIR 634

WP ^"048604708 560 KDLSNFLRNE- -YN- -LDDVIIDGIE-N- -KFNASFNTYHDFLKLKIDP KVLDDPANEPMFEEIVKILTIFEDRKMLR 630

WP ^"010750235 561 KKLQHFLSAN- -YN- -IEDAEILGVDKV- —FNSSYATYHDFLELAKPY ELLEQPEMEEMFEDIVKIITIFEDREMVR 636

AII16583 601 KQLKEDYFKK- -IECFDSVEISGVEDR- —FNASLGTYHDLLKIIKDK DFLDNEENEDILEDIVLTLTLFEDREMIE 672

WP 029073316 576 NAMKKWLVKNqyFSNTDDIKIEGFQKEn -ACSTSLTPWIDFTKIFGEI NNSNYELIEKIIYDVTVFEDKKILR 647

WP ^"031589969 576 NAMKKWLVKNqyFSNTDDIKIEGFQKEn -ACSTSLTPWIDFTKIFGKI NESNYDFIEKIIYDVTVFEDKKILR 647

KDA45870 558 KMVIKHLKW- -MPAIRIQALKGLDNGk —FNASYGTYKDLVDMGVAP ELLNDEVNSEKWEDIIKTLTIFEGRKLIK 630

WP 039099354 579 KNIQDYLVSEk —RYASRPAITGLSDEnk-FNSRLSTYHDLKTIVGDA —VDDVDKQADLEKCIEWSTIFEDGKIYS 650

AKP02966 561 KKLTKWLIAQg YYKNPILIGLSQKd -EFNSTLTTYLDMKKIFGSS -FMENNKNYNQIEELIEWLTIFEDKQILN 632

WP 010991369 567 KDLELFLRNM- -SH- -VESPTIEGLE-D- -SFNSSYSTYHDLLKVGIKQ EILDNPVNTEMLENIVKILTVFEDKRMIK 637

WP ^"033838504 567 KDLELFLRNM- -SH- -VESPTIEGLE-D- -SFNSSYSTYHDLLKVGIKQ EILDNPVNTEMLENIVKILTVFEDKRMIK 637

EHN60060 570 KDLELFLRNM- -SH- -VESPTIEGLE-D- -SFNSSYSTYHDLLKVGIKQ EILDNPVNTEMLENIVKILTVFEDKRMIK 640

EFR89594 336 KDLELFLRNM- -SH- -VESPTIEGLE-D- -SFNSSYSTYHDLLKVGIKQ EILDNPVNTEMLENIVKILTVFEDKRMIK 406

WP 038409211 567 KDLERFLYTI- -NH- -IESPTIEGVE-D- -AFNSSFATYHDLQKGGVTQ EILDNPLNADMLEEIVKILTVFEDKRMIK 637

EFR95520 186 KDLERFLYTI- -NH- -IESPTIEGVE-D- -AFNSSFATYHDLQKGGVTQ EILDNPLNADMLEEIVKILTVFEDKRMIK 256

WP 003723650 567 KDLELFLRNI- -NH- -IESPTIEGLE-D- -SFNASYATYHDLLKVGMKQ EILDNPLNTEMLEDIVKILTVFEDKPMIK 637

WP ^"003727705 567 KDLELFLRNI- -NH- -IESPTIEGLE-D- -SFNASYATYHDLLKVGLKQ EILDNPLNTEILEDIVKILTVFEDKRMIK 637

WP ^"003730785 567 KDLELFLRNI- -NH- -IESPTIEGLE-D- -SFNASYATYHDLLKVGLKQ EILDNPLNTEILEDIVKILTVFEDKRMIK 637

WP ^"003733029 567 KDLELFLRNI- -NQ- -IESPTIEGLE-D- -SFNASYATYHDLLKVGMKQ EILDNPLNTEMLEDIVKILTVFEDKRMIK 637

WP ^"003739838 567 KDLEQFLRNM- -SH- -IESPTIEGLE-D- -SFNSSYATYHDLLKVGIKQ EVLENPLNTEMLEDIVKILTVFEDKRMIK 637

WP 014601172 567 KDLELFLRNI- -NH-IESPTIEGLE-D--^■SFNASYATYHDLLKVGMKQ EILDNPLNTEMLEDIVKILTVFEDKPMIK 637

WP 023548323 567 KDLELFLRNI- -NH-VESPTIEGLE-D-- ^■SFNASYATYHDLMKVGIKQ EILDNPLNTEMLEDIVKILTVFEDKRMIK 637

WP 031665337 567 KDLELFLRNI- -NQ--IESPTIEGLE-D-- ^■SFNASYATYHDLLKVGMKQ EILDNPLNTEMLEDIVKILTVFEDKRMIK 637

WP 031669209 567 KDLELFLRNI- -NQ--IESPTIEGLE-D-- ^■SFNASYATYHDLLKVGMKQ EILDNPLNTEMLEDIVKILTVFEDKRMIK 637

WP 033920898 567 KDLELFLRNI- -NH-VESPTIEGLE-D-- ^■SFNASYATYHDLMKVGIKQ EILDNPLNTEMLEDIVKILTVFEDKRMIK 637

AKI42028 570 KDLELFLRNI- -NH-IESPTIEGLE-D-- ^■SFNASYATYHDLLKVGMKQ EILDNPLNTEMLEDIVKILTVFEDKPMIK 640

AKI50529 570 KDLELFLRNI- -NH-VESPTIEGLE-D-- ^■SFNASYATYHDLMKVGIKQ EILDNPLNTEMLEDIVKILTVFEDKRMIK 640

EFR83390 15 KDLELFLRNI- -NQ-IESPTIEGLE-D-- ^■SFNASYATYHDLLKVGMKQ EILDNPLNTEMLEDIVKILTVFEDKRMIK 85

WP 046323366 567 KDLELFLYNM- -NH-VESPTVEGVE-D-- AFNSSFTTYHDLQKVGVPQ EILDDPLNTEMLEEIIKILTVFEDKRMIN 637

AKE81011 578 KQLKEDYFKK- -IECFDSVEISGVEDR-- -FNASLGTYHDLLKIIKDK DFLDNEENEDILEDIVLTLTLFEDREMIE 649

CU082355 572 KKLKNWL NqcCR—KDAEIKGFQKEn- QFSTSLTPWIDFTNIFGKI DQSNFDLIEKIIYDLTVFEDKKIMK 641

WP 033162887 573 KKLKDWLVTHqyYDINEELKIEGYQKDl- QFSTSLAPWIDFTKIFGEI NASNYQLIEKIIYDISIFEDKKILK 644

AGZ 01981 595 KQLKEDYFKK—IECFDSVEISGVEDR-- -FNASLGTYHDLLKIIKDK DFLDNEENEDILEDIVLTLTLFEDREMIE 666

AKA60242 562 KQLKEDYFKK—IECFDSVEISGVEDR-- -FNASLGTYHDLLKIIKDK DFLDNEENEDILEDIVLTLTLFEDREMIE 633

AKS40380 562 KQLKEDYFKK—IECFDSVEISGVEDR-- -FNASLGTYHDLLKIIKDK DFLDNEENEDILEDIVLTLTLFEDREMIE 633

4UN5 B 566 KQLKEDYFKK—IECFDSVEISGVEDR-- -FNASLGTYHDLLKIIKDK DFLDNEENEDILEDIVLTLTLFEDREMIE 637

WP 010922251 634 ERLKTYAHLFDDKVMKQLKR-RRYTGW(G|RLSRKLINGIRDK QSGKTILDFLK -DGf---ANRNF0QLIHDDSL 702

WP ^"039695303 638 ERLQKYSDIFTANQLKKLER-RHYTGWGRLSYKLINGIRNK ENNKTILDYLI DDG— -SANRNFMQLINDDTL 706

WP ^"045635197 633 QRLAQYDSLFDEKVIKALTR-RHYTGWGKLSAKLINGICDK QTGNTILDYLI DDG— -KINRNFMQLINDDGL 701

5AXW A 369 EELTNLNSELTQEEIEQISN1KGYTGTHNLSLKAINLILDE 426

WP 009880683 318 ERLKTYAHLFDDKVMKQLKR-RRYTGWGRLSRKLINGIRDK QSGKTILDFLK -DGf- —ANRNFMQLIHDDSL 386

WP ^"010922251 634 ERLKTYAHLFDDKVMKQLKR-RRYTGWGRLSRKLINGIRDK QSGKTILDFLK -DGf- —ANRNFMQLIHDDSL 702

WP ^"011054416 634 ERLKTYAHLFDDKVMKQLKR-RRYTGWGRLSRKLINGIRDK QSGKTILDFLK -DGf- —ANRNFMQLIHDDSL 702

WP ^"011284745 634 ERLKTYAHLFDDKVMKQLKR-RRYTGWGRLSRKLINGIRDK QSGKTILDFLK -DGf- —ANRNFMQLIHDDSL 702

WP ^"011285506 634 ERLKTYAHLFDDKVMKQLKR-RRYTGWGRLSRKLINGIRDK QSGKTILDFLK -DGf- —ANRNFMQLIHDDSL 702

WP ^"011527619 634 ERLKTYAHLFDDKVMKQLKR-RRYTVWGRLSRKLINGIRDK QSGKTILDFLK -DGf- —ANRNFMQLIHDDSL 702

WP ^"012560673 634 ERLKTYAHLFDDKVMKQLKR-RRYTGWGRLSRKLINGIRDK QSGKTILDFLK -DGf- —ANRNFMQLIHDDSL 702

WP ^"014407541 634 ERLKTYAHLFDDKVMKQLKR-RRYTGWGRLSRKLINGIRDK QSGKTILDFLK -DGf- —ANRNFMQLIHDDSL 702

WP ^"020905136 634 ERLKTYAHLFDDKVMKQLKR-RRYTGWGRLSRKLINGIRDK QSGKTILDFLK -DGf- —ANRNFMQLIHDDSL 702

WP ^"023080005 634 ERLKKYANLFDDKVMKQLKR-RHYTGWGRLSRKLINGIRDK QSGKTILDFLK -DGf- —ANRNFMQLINDDSL 702

WP ^"023610282 634 ERLKKYANLFDDKVMKQLKR-RHYTGWGRLSRKLINGIRDK QSGKTILDFLK -DGf- —ANRNFMQLINDDSL 702

WP ^"030125963 634 ERLKTYAHLFDDKVMKQLKR-RRYTGWGRLSRKLINGIRDK QSGKTILDFLK -DGf- —ANRNFMQLIHDDSL 702

WP ^"030126706 634 ERLKTYAHLFDDKVMKQLKR-RRYTGWGRLSRKLINGIRDK QSGKTILDFLK -DGf- —ANRNFMQLIHDDSL 702

WP ^"031488318 634 ERLKTYAHLFDDKVMKQLKR-RRYTGWGRLSRKLINGIRDK QSGKTILDFLK -DGf- —ANRNFMQLIHDDSL 702

WP ^"032460140 634 ERLKTYAHLFDDKVMKQLKR-RRYTGWGRLSRKLINGIRDK QSGKTILDFLK -DGf- —ANRNFMQLIHDDSL 702

WP ^"032461047 634 ERLKTYAHLFDDKVMKQLKR-RRYTGWGRLSRKLINGIRDK QSGKTILDFLK -DGf- —ANRNFMQLIHDDSL 702

WP ^"032462016 634 ERLKTYAHLFDDKVMKQLKR-RRYTGWGRLSRKLINGIRDK QSGKTILDFLK -DGf- —ANRNFMQLIHDDSL 702

WP ^"032462936 634 ERLKKYAHLFDDKVMKQLKR-RRYTGWGRLSRKLINGIRDK QSGKTILDFLK -DGf- —ANRNFMQLIHDDSL 702

WP ^"032464890 634 ERLKTYAHLFDDKVMKQLKR-RRYTGWGRLSRKLINGIRDK QSGKTILDFLK -DGf- —ANRNFMQLIHDDSL 702

WP ^"033888930 459 ERLKTYAHLFDDKVMKQLKR-RRYTGWGRLSRKLINGIRDK QSGKTILDFLK -DGf- —ANRNFMQLIHDDSL 527

WP ^"038431314 634 ERLKTYAHLFDDKVMKQLKR-RRYTGWGRLSRKLINGIRDK QSGKTILDFLK -DGf- —ANRNFMQLIHDDSL 702

WP ^"038432938 634 ERLKKYANLFDDKVMKQLKR-RHYTGWGRLSRKLINGIRDK QSGKTILDFLK -DGf- —ANRNFMQLINDDSL 702

WP ^"038434062 634 ERLKTYAHLFDDKVMKQLKR-RRYTGWGRLSRKLINGIRDK QSGKTILDFLK -DGf- —ANRNFMQLIHDDSL 702

BAQ51233 545 ERLKTYAHLFDDKVMKQLKR-RRYTGWGRLSRKLINGIRDK QSGKTILDFLK -DGf- —ANRNFMQLIHDDSL 613

KGE60162

KGE60856

WP 002989955 634 ERLKTYAHLFDDKVMKQLKR- RRYTGWGRLSRKLINGIRDK QSGKTILDFLK -DGf- —ANRNFMQLIHDDSL 702

WP ^"003030002 635 QRLQKYSDIFTKAQLKKLER-RHYTGWGRLSYKLINGIRNK ENKKTILDYLI DDG— -YANRNFMQLINDDAL 703

WP ^"003065552 638 ERLQKYSDIFTADQLKKLER-RHYTGWGRLSYKLINGIRNK ENNKTILDYLI DDG— -SANRNFMQLINDDTL 706

WP ^"001040076 633 KRLDIYKDFFTESQLKKLYR-RHYTGWGRLSAKLINGIRNK ENQKTILDYLI DDG— -SANRNFMQLIKDAGL 701

WP ^"001040078 636 KRLENYKDLFTESQLKKLYR-RHYTGWGRLSAKLINGIRDK ESQKTILDYLI DDG— -RSNRNFMQLINDDGL 704

WP ^"001040080 636 KRLENYKDLFTESQLKKLYR-RHYTGWGRLSAKLINGIRDK ESQKTILDYLI DDG— -RSNRNFMQLINDDGL 704

WP ^"001040081 636 KRLENYKDLFTESQLKKLYR-RHYTGWGRLSAKLINGIRDK ESQKTILDYLI DDG— -RSNRNFMQLINDDGL 704

WP ^"001040083 636 KRLENYKDLFTESQLKKLYR-RHYTGWGRLSAKLINGIRDK ESQKTILDYLI DDG— -RSNRNFMQLINDDGL 704

WP ^"001040085 636 KRLENYKDLFTESQLKKLYR-RHYTGWGRLSAKLINGIRDK ESQKTILDYLI DDG— -RSNRNFMQLINDDGL 704

WP 001040087 636 KRLENYKDLFTESQLKKLYR RHYTGWGRLSAKLINGIRDK ESQKTILDYLI DDG RSNRNFMQLINDDGL 704

WP ^"001040088 636 KRLENYKDLFTESQLKKLYR RHYTGWGRLSAKLINGIRDK ESQKTILDYLI DDG RSNRNFMQLINDDGL 704

WP ^"001040089 636 KRLENYKDLFTESQLKKLYR RHYTGWGRLSAKLINGIRDK ESQKTILDYLI DDG RSNRNFMQLINDDGL 704

WP ^"001040090 636 KRLENYKDLFTESQLKKLYR RHYTGWGRLSAKLINGIRDK ESQKTILDYLI DDG RSNRNFMQLINDDGL 704

WP ^"001040091 636 KRLENYKDLFTESQLKKLYR RHYTGWGRLSAKLINGIRDK ESQKTILDYLI DDG RSNRNFMQLINDDGL 704

WP ^"001040092 636 KRLENYKDLFTESQLKKLYR RHYTGWGRLSAKLINGIRDR ESQKTILDYLI SDG RANRNFMQLINDDGL 704

WP ^"001040094 633 KRLDIYKDFFTESQLKKLYR RHYTGWGRLSAKLINGIRNK ENQKTILDYLI DDG SANRNFMQLIKDAGL 701

WP ^"001040095 633 KRLDIYKDFFTESQLKKLYR RHYTGWERLSAKLINGIRNK ENQKTILDYLI DDG SANRNFMQLIKDAGL 701

WP ^"001040096 633 KRLDIYKDFFTESQLKKLYR RHYTGWGRLSAKLINGIRNK ENQKTILDYLI DDG SANRNFMQLIKDAGL 701

WP ^"001040097 633 KRLDIYKDFFTESQLKKLYR RHYTGWGRLSAKLINGIRNK ENQKTILDYLI DDG SANRNFMQLIKDAGL 701

WP ^"001040098 633 KRLDIYKDFFTESQLKKLYR RHYTGWGRLSAKLINGIRNK ENQKTILDYLI DDG SANRNFMQLIKDAGL 701

WP ^"001040099 633 KRLDIYKDFFTESQLKKLYR RHYTGWGRLSAKLINGIRNK ENQKTILDYLI DDG SANRNFMQLIKDAGL 701

WP ^"001040100 633 KRLDIYKDFFTESQLKKLYR RHYTGWGRLSAKLINGIRNK ENQKTILDYLI DDG SANRNFMQLIKDAGL 701

WP ^"001040104 636 KRLENYKDLFTESQLKKLYR RHYTGWGRLSAKLINGIRDK ESQKTILDYLI DDG RSNRNFMQLINDDGL 704

WP ^"001040105 636 KRLENYKDLFTESQLKKLYR RHYTGWGRLSAKLINGIRDK ESQKTILDYLI DDG RSNRNFMQLINDDGL 704

WP ^"001040106 636 KRLENYKDLFTESQLKKLYR RHYTGWGRLSAKLINGIRDK ESQKTILDYLI SDG RANRNFMQLIHDDGL 704

WP ^"001040107 636 KRLENYKDLFTESQLKKLYR RHYTGWGRLSAKLINGIRDK ESQKTILDYLI SDG RANRNFMQLIHDDGL 704

WP ^"001040108 636 KRLENYKDLFTESQLKKLYR RHYTGWGRLSAKLINGIRDK ESQKTILDYLI SDG RANRNFMQLIHDDGL 704

WP ^"001040109 636 KRLENYKDLFTESQLKKLYR RHYTGWGRLSAKLINGIRDK ESQKTILDYLI SDG RANRNFMQLIHDDGL 704

WP ^"001040110 636 KRLENYKDLFTESQLKKLYR RHYTGWGRLSAKLINGIRDK ESQKTILDYLI SDG RANRNFMQLIHDDGL 704

WP ^"015058523 636 KRLENYKDLFTESQLKKLYR RHYTGWGRLSAKLINGIRDR ESQKTILDYLI SDG RANRNFMQLINDDGL 704

WP ^"017643650 633 KRLDIYKDFFTESQLKKLYR RHYTGWGRLSAKLINGIRNK ENQKTILDYLI DDG SANRNFMQLIKDAGL 701

WP ^"017647151 636 KRLENYKDLFTESQLKKLYR RHYTGWGRLSAKLINGIRDK ESQKTILDYLI DDG KSNRNFMQLIHDDGL 704

WP ^"017648376 636 KRLENYKDLFTESQLKKLYR RHYTGWGRLSAKLINGIRDK ESQKTILDYLI DDG KSNRNFMQLIHDDGL 704

WP ^"017649527 636 KRLENYKDLFTESQLKKLYR RHYTGWGRLSAKLINGIRDK ESQKTILDYLI DDG RSNRNFMQLINDDGL 704

WP ^"017771611 636 KRLENYKDLFTESQLKKLYR RHYTGWGRLSAKLINGIRDK ESQKTILDYLI SDG RANRNFMQLIHDDGL 704

WP ^"017771984 636 KRLENYKDLFTESQLKKLYR RHYTGWGRLSAKLINGIRDK ESQKTILDYLI DDG RSNRNFMQLINDDGL 704

CFQ25032 636 KRLENYKDLFTESQLKKLYR RHYTGWGRLSAKLINGIRDK ESQKTILDYLI DDG RSNRNFMQLINDDGL 704

CFV16040 636 KRLENYKDLFTESQLKKLYR RHYTGWGRLSAKLINGIRDK ESQKTILDYLI DDG RSNRNFMQLINDDGL 704

KLJ37842 636 KRLENYKDLFTESQLKKLYR RHYTGWGRLSAKLINGIRDK ESQKTILDYLI DDG RSNRNFMQLINDDGL 704

KLJ72361 636 KRLENYKDLFTESQLKKLYR RHYTGWGRLSAKLINGIRDK ESQKTILDYLI DDG RSNRNFMQLINDDGL 704

KLL20707 636 KRLENYKDLFTESQLKKLYR RHYTGWGRLSAKLINGIRDK ESQKTILDYLI DDG RSNRNFMQLINDDGL 718

KLL42645 636 KRLENYKDLFTESQLKKLYR RHYTGWGRLSAKLINGIRDK ESQKTILDYLI SDG RANRNFMQLIHDDGL 704

WP 047207273 636 KRLENYKDLFTESQLKKLYR RHYTGWGRLSAKLINGIRDK ESQKTILDYLI DDG RSNRNFMQLINDDGL 704

WP ^"047209694 633 KRLDIYKDFFTESQLKKLYR RHYTGWGRLSAKLINGIRNK ENQKTILDYLI DDG SANRNFMQLIKDAGL 701

WP ^"050198062 636 KRLENYKDLFTESQLKKLYR RHYTGWGRLSAKLINGIRDK ESQKTILDYLI DDG RSNRNFMQLINDDGL 704

WP ^"050201642 636 KRLENYKDLFTESQLKKLYR RHYTGWGRLSAKLINGIRDK ESQKTILDYLI DDG RSNRNFMQLINDDGL 704

WP ^"050204027 636 KRLENYKDLFTESQLKKLYR RHYTGWGRLSAKLINGIRDK ESQKTILDYLI SDG RANRNFMQLIHDDGL 704

WP ^"050881965 636 KRLENYKDLFTESQLKKLYR RHYTGWGRLSAKLINGIRDK ESQKTILDYLI DDG RSNRNFMQLINDDGL 704

WP_050886065 636 KRLENYKDLFTESQLKKLYR-RHYTGWGRLSAKLINGIRDK ESQKTILDYLI DDG—-RSNRNFMQLINDDGL 704

AHN30376 636 KRLENYKDLFTESQLKKLYR-RHYTGWGRLSAKLINGIRDR ESQKIILDYLI SDG— -RANRNFMQLINDDGL 704

EA078426 636 KRLENYKDLFTESQLKKLYR-RHYTGWGRLSAKLINGIRDK ESQKTILDYLI DDG— -RSNRNFMQLINDDGL 704

CCW42055 636 KRLDIYKDFFTESQLKKLYR-RHYTGWGRLSAKLINGIRNK ENQKTILDYLI DDG— -SANRNFMQLIKDAGL 704

WP_003041502 635 QRLQKYSDIFTKAQLKKLER-RHYTGWGRLSYKLINGIRNK ENKKTILDYLI DDG— -YANRNFMQLINDDAL 703

WP_037593752 636 QRLQKYSDIFTKAQLKKLER-RHYTGWGRLSYKLINGIRNK ENKKTILDYLI DDG— -YANRNFMQLINDDAL 704

WP_049516684 636 QRLQKYSDIFTTQQLKKLER-RHYTGWGRLSYKLINGIRNK ENKKTILDYLI DDG— -YANRNFMQLINDDAL 704

GAD46167 635 QRLQKYSDIFTKAQLKKLER-RHYTGWGRLSYKLINGIRNK ENKKTILDYLI DDG— -YANRNFMQLINDDAL 703

WP 018363470 636 QRLQKYSDIFTKQQLKKLER-RHYTGWGRLSYKLINGIRNK ENNKTILDYLI DDG— -SANRNFMQLINDDAL 704

WP ^"003043819 644 ERLKTYAHLFDDKVMKQLKR-RHYTGWGRLSRKMINGIRDK QSGKTILDFLK -DGf- —SNRNFMQLIHDDSL 712

WP ^"006269658 635 QRLQKYSDIFTKAQLKKLER-RHYTGWGRLSYKLINGIRNK ENKKTILDYLI DDG— -YANRNFMQLINDDAL 703

WP ^"048800889 635 QRLQKYSDIFTKAQLKKLER-RHYTGWGRLSYKLINGIRNK ENNKTILEYLV DDG— -YANRNFMQLINDDTL 703

WP ^"012767106 634 ERLKKYANLFDDKVMKQLKR-RHYTGWGRLSRKLINGIRDK QSGKTILDFLK -DGf- —ANRNFMQLINDDSL 702

WP ^"014612333 634 ERLKKYANLFDDKVMKQLKR-RHYTGWGRLSRKLINGIRDK QSGKTILDFLK -DGf- —ANRNFMQLINDDSL 702

WP ^"015017095 634 ERLKTYAHLFDDKVMKQLKR-RHYTGWGRLSRKLINGIRDK QSGKTILDFLK -DGf- —ANRNFIQLIHDDSL 702

WP ^"015057649 634 ERLKKYANLFDDKVMKQLKR-RHYTGWGRLSRKLINGIRDK QSGKTILDFLK -DGf- —ANRNFMQLINDDSL 702

WP ^"048327215 634 ERLKTYAHLFDDKVMKQLKR-RHYTGWGRLSRKLINGIRDK QSGKTILDFLK -DGf- —ANRNFIQLIHDDSL 702

WP ^"049519324 634 ERLKTYAHLFDDKVMKQLKR-RHYTGWGRLSRKLINGIRDK QSGKTILDFLK -DGf- —ANRNFIQLIHDDSL 702

WP ^"012515931 634 KRLDQYAHLFDKWLNKLER-HHYTGWGRLSGKLINGIRDK QSGKTILDFLK -DGf- —ANRNFMQLIHDSEL 702

WP ^"021320964 634 KRLDQYAHLFDKWLNKLER-HHYTGWGRLSGKLINGIRDK QSGKTILDFLK -DGf- —ANRNFMQLIHDSEL 702

WP ^"037581760 634 KRLDQYAHLFDKWLNKLER-HHYTGWGRLSGKLINGIRDK QSGKTILDFLK -DGf- —ANRNFMQLIHDSEL 702

WP ^"004232481 635 ERLQKYSDIFTSQQLKKLER-RHYTGWGRLSYKLINGIRNK ENNKTILDFLI DDG— -DANRNFMQLINDDSL 703

WP ^"009854540 636 ERLQKYSDIFTANQLKKLER-RHYTGWGRLSYKLINGIRNK ENNKTILDYLI DDG— -SANRNFMQLINDDTL 704

WP ^"012962174 636 QRLQKYSDIFTPQQLKKLER-RHYTGWGRLSYKLINGIRNK ENGKSILDYLI DDG— -YANRNFMQLISDDTL 704

WP ^"039695303 638 ERLQKYSDIFTANQLKKLER-RHYTGWGRLSYKLINGIRNK ENNKTILDYLI DDG— -SANRNFMQLINDDTL 706

WP ^"014334983 635 ERLQKYSDFFTSQQLKKLER-RHYTGWGRLSYKLINGIRNK ENNKTILDFLI DDG— -HANRNFMQLINDESL 703

WP ^"003099269 634 RRLVKYADVFEKSVLKKLKK-RHYTGWGRLSQKLINGIKDK QTGKTILGFLK -DGv- —ANRNFMQLINDSSL 702

AHY15608 634 RRLVKYADVFEKSVLKKLKK-RHYTGWGRLSQKLINGIKDK QTGKTILGFLK -DGv- —ANRNFMQLINDSSL 702

AHY17476 634 RRLVKYADVFEKSVLKKLKK-RHYTGWGRLSQKLINGIKDK QTGKTILGFLK -DGv- —ANRNFMQLINDSSL 702 ESR09100

AGM98575 634 RRLVKYADVFEKSVLKKLKK- RHYTGWGRLSQKLINGIKDK QTGKTILGFLK -DGv- —ANRNFMQLINDSSL 702

ALF27331 635 KRLENYSDLLTKEQVKNLER-RHYTGWGRLSAELIHGIRNK ESRKTILDYLI DDG— -NSNRNFMQLINDDAL 703

WP_018372492 648 KRLSELNIPFENKIIKKLAR-KKYTGWGNLSRKLIDGIRNR ETNRTILGHLI DDGf- —SNRNLMQLINDDGL 716

WP_045618028 634 QRLAHYASIFDEKVIKALTR-RHYTGWGKLSAKLINGIYDK QSKKTILDYLI DDG— -EINRNFMQLINDDGL 702

WP_045635197 633 QRLAQYDSLFDEKVIKALTR-RHYTGWGKLSAKLINGICDK QTGNTILDYLI DDG— -KINRNFMQLINDDGL 701

WP_002263549 635 KRLENYSDLLTKEQVKKLER-RHYTGWGRLSAELIHGIRNK ESRKTILDYLI DDG— -NSNRNFMQLINDDAL 703

WP_002263887 635 KRLENYSDLLTKEQVKKLER-RHYTGWGRLSAELIHGIRNK ESRKTILDYLI DDG— -NSNRNFMQLINDDAL 703

WP_002264920 635 KRLKNYSDLLTKEQLKKLER-RHYTGWGRLSAELIHGIRNK ESRKTILDYLI DDG— -NSNRNFMQLINDDAL 703

WP 002269043 635 KRLKNYSDLLTKEQLKKLER-RHYTGWGRLSAELIHGIRNK ESRKTILDYLI DDG— -NSNRNFMQLINDDAL 703

WP 002269448 635 KRLENYSDLLTKEQVKKLER-RHYTGWGRLSAELIHGIRNK ESRKTILDYLI DDG-—NSNRNFMQLINDDAL 703

WP ^"002271977 635 KRLENYSDLLTKEQVKKLER-RHYTGWGRLSAELIHGIRNK ESRKTILDYLI DDG- —NSNRNFMQLINDDAL 703

WP ^"002272766 635 KRLENYSDLLTKEQVKKLER-RHYTGWGRLSAELIHGIRNK ESRKTILDYLI DDG- —NSNRNFMQLINDDAL 703

WP ^"002273241 635 KRLENYSDLLTKEQVKKLER-RHYTGWGRLSAELIHGIRNK ESRKTILDYLI DDG- —NSNRNFMQLINDDAL 703

WP ^"002275430 635 KRLENYSDLLTKEQVKKLER-RHYTGWGRLSAELIHGIRNK ESRKTLLDYLI DDG- —NSNRNFMQLINDDAL 703

WP ^"002276448 635 KRLENYSDLLTKEQVKKLER-RHYTGWGRLSAELIHGIRNK ESRKTILDYLI DDG- —NSNRNFMQLINDDAL 703

WP ^"002277050 636 QRLAKYADVFDKKVIDQLAR-RHYTGWGRLSAKLLNGIRDK QSCKTIMDYLI DDA- —QSNRNLMQLITDDNL 704

WP ^"002277364 635 KRLENYSDLLTKEQVKKLER-RHYTGWGRLSAELIHGIRNK ESRKTILDYLI DDG- —NSNRNFMQLINDDAL 703

WP ^"002279025 635 KRLKNYSDLLTKEQLKKLER-RHYTGWGRLSAELIHGIRNK ESRKTILDYLI DDG- —NSNRNFMQLINDDAL 703

WP ^"002279859 635 KRLKNYSDLLTKEQLKKLER-RHYTGWGRLSAELIHGIRNK ESRKTILDYLI DDG- —NSNRNFMQLINDDAL 703

WP ^"002280230 635 KRLENYSDLLTKEQVKKLER-RHYTGWGRLSAELIHGIRNK ESRKTILDYLI DDG- —NSNRNFMQLINDDAL 703

WP ^"002281696 635 KRLENYSDLLTKEQVKKLER-RHYTGWGRLSAELIHGIRNK ESRKTILDYLI DDG- —NSNRNFMQLINDDAL 703

WP ^"002282247 636 QRLAKYADVFDKKVIDQLAR-RHYTGWGRLSAKLLNGIRDK QSCKTIMDYLI DDA- —QSNRNLMQLITDDNL 704

WP ^"002282906 635 KRLENYSDLLTKEQVKKLER-RHYTGWGRLSAELIHGIRNK ESRKTILDYLI DDG- —NSNRNFMQLINDDAL 703

WP ^"002283846 635 KRLKNYSDLLTKEQLKKLER-RHYTGWGRLSAELIHGIRNK ESRKTILDYLI DDG- —NSNRNFMQLINDDAL 703

WP ^"002287255 635 KRLENYSDLLTKEQVKKLER-RHYTGWGRLSAELIHGIRNK ESRKTILDYLI DDG- —NSNRNFMQLINDDAL 703

WP ^"002288990 635 KRLKNYSDLLTKEQLKKLER-RHYTGWGRLSAELIHGIRNK ESRKTILDYLI DDG- —NSNRNFMQLINDDAL 703

WP ^"002289641 635 KRLENYSDLLTKEQVKKLER-RHYTGWGRLSAELIHGIRNK ESRKTILDYLI DDG- —NSNRNFMQLINDDAL 703

WP ^"002290427 635 KRLKNYSDLLTKEQLKKLER-RHYTGWGRLSAELIHGIRNK ESRKTILDYLI DDG- —NSNRNFMQLINDDAL 703

WP ^"002295753 635 KRLENYSDLLTKEQVKKLER-RHYTGWGRLSAELIHGIRNK ESRKTILDYLI DDG- —NSNRNFMQLINDDAL 703

WP ^"002296423 635 KRLKNYSDLLTKEQLKKLER-RHYTGWGRLSAELIHGIRNK ESRKTILDYLI DDG- —NSNRNFMQLINDDAL 703

WP ^"002304487 645 QRLQKYSDIFTKAQLKKLER-RHYTGWGRLSYKLINGIRDK QSNKTILGYLI DDG- —YSNRNFMQLINDDAL 713

WP ^"002305844 635 KRLENYSDLLTKEQVKKLER-RHYTGWGRLSAELIHGIRNK ESRKTILDYLI DDG- —NSNRNFMQLINDDAL 703

WP ^"002307203 635 KRLENYSDLLTKEQVKKLER-RHYTGWGRLSAELIHGIRNK ESRKTLLDYLI DDG- —NSNRNFMQLINDDAL 703

WP ^"002310390 635 KRLKNYSDLLTKEQLKKLER-RHYTGWGRLSAELIHGIRNK ESRKTILDYLI DDG- —NSNRNFMQLINDDAL 703

WP ^"002352408 635 KRLENYSDLLTKEQVKKLER-RHYTGWGRLSAELIHGIRNK ESRKTLLDYLI DDG- —NSNRNFMQLINDDAL 703

WP ^"012997688 635 KRLENYSDLLTKEQVKKLER-RHYTGWGRLSAELIHGIRNK ESRKTILDYLI DDG- —NSNRNFMQLINDDAL 703

WP ^"014677909 635 KRLKNYSDLLTKEQLKKLER-RHYTGWGRLSAELIHGIRNK ESRKTILDYLI DDG- —NSNRNFMQLINDDAL 703

WP ^"019312892 635 KRLENYSDLLTKEQVKKLER-RHYTGWGRLSAELIHGIRNK ESRKTILDYLI DDG- —NSNRNFMQLINDDAL 703

WP ^"019313659 635 KRLENYSDLLTKEQVKKLER-RHYTGWGRLSAELIHGIRNK ESRKTILDYLI DDG- —NSNRNFMQLINDDAL 703

WP ^"019314093 635 KRLENYSDLLTKEQVKKLER-RHYTGWGRLSAELIHGIRNK ESRKTLLDYLI DDG- —NSNRNFMQLINDDAL 703

WP ^"019315370 635 KRLENYSDLLTKEQVKKLER-RHYTGWGRLSAELIHGIRNK ESRKTLLDYLI DDG- —NSNRNFMQLINDDAL 703

WP ^"019803776 635 KRLENYSDLLTKEQVKKLER-RHYTGWGRLSAELIHGIRNK ESRKTILDYLI DDG- —NSNRNFMQLINDDAL 703

WP ^"019805234 635 KRLKNYSDLLTKEQLKKLER-RHYTGWGRLSAELIHGIRNK ESRKTILDYLI DDG- —NSNRNFMQLINDDAL 703

WP ^"024783594 635 KRLENYSDLLTKEQVKKLER-RHYTGWGRLSAELIHGIRNK ESRKTILDYLI DDG- —NSNRNFMQLINDDAL 703

WP ^"024784288 636 QRLAKYADVFDKKVIDQLAR-RHYTGWGRLSAKLLNGIRDK QSCKTIMDYLI DDA- —QSNRNLMQLITDDNL 704

WP ^"024784666 635 KRLENYSDLLTKEQVKKLER-RHYTGWGRLSAELIHGIRNK ESRKTILDYLI DDG- —NSNRNFMQLINDDAL 703

WP ^"024784894 635 KRLENYSDLLTKEQVKKLER-RHYTGWGRLSAELIHGIRNK ESRKTILDYLI DDG- —NSNRNFMQLINDDAL 703

WP ^"024786433 636 QRLAKYADVFDKKVIDQLAR-RHYTGWGRLSAKLLNGIRDK QSCKTIMDYLI DDA- —QSNRNLMQLITDDNL 704

WP_049473442 635 KRLENYSDLLTKEQVKKLER RHYTGWGRLSAELIHGIRNK ESRKTILDYLI DDG NSNRNFMQLINDDAL 703

WP_049474547 635 KRLENYSDLLTKEQVKKLER RHYTGWGRLSAELIHGIRNK ESRKTILDYLI DDG NSNRNFMQLINDDAL 703

EMC03581 628 KRLENYSDLLTKEQVKKLER RHYTGWGRLSAELIHGIRNK ESRKTILDYLI DDG NSNRNFMQLINDDAL 696

WP_000428612 636 QRLAQYDSLFDEKVIKALTR RHYTGWGKLSSKLINGIRDK QTGKTILDYLM DDG YNNRNFMQLINDDEL 704

WP_000428613 634 QRLAQYDSLFDEKVIKALIR RHYTGWGKLSAKLIDGICDK QTGNTILDYLI DDG KNNRNFMQLINDDGL 702

WP_049523028 633 QRLNQYDSIFDEKVIKALTR RHYTGWGKLSAKLINGIRDK KTSKTILDYLI DDG YSNRNFMQLINDDGL 701

WP_003107102 603 KRLSKYESIFDPSILKKLKK RHYTGWGRLSQKLINGIRDK QTGKTILDFLI -DGq ANRNFMQLINDPSL 671

WP_054279288 636 NRLAVYEDLFDQNVLKQLKR RHYTGWGRLSKQLINGMRDK HTGKTILDFLK -DGf INRNFMQLINDDNL 704

WP_049531101 634 QRLAQYASIFDEKVIKTLTR RHYTGWGKLSAKLINCIRDR KTGKTILDYLI DDG YNNRNFMQLINDDGL 702

WP_049538452 634 QRLAQYDSIFDEKVIKALTR RHYTGWGKLSAKLINGIRDK QTGKTILDYLI DDG YSNRNFMQLINDDGL 702

WP_049549711 634 QRLAQYDSLFDKKVIKALTR RHYTGWGKLSAKLINGICDK QTGNTILDYLI DDG EINRNFMQLINDDGL 702

WP 007896501 637 KRLAKYANLFEKSVLKKLRK RHYRGWGRLSRQLIDGMKDK ASGKTILDFLK -DDf ANRNFIQLINDSSL 705

EFR44625 589 KRLAKYANLFEKSVLKKLRK RHYRGWGRLSRQLIDGMKDK ASGKTILDFLK -DDf ANRNFIQLINDSSL 657

WP_002897477 633 QRLAQYDTLFDEKVIKALTR RHYTGWGKLSAKLINGIRDK QSGKTILDYLI DDD KINRNFMQLINDDGL 701

WP_002906454 633 QRLAQYDTLFDEKVIKALTR RHYTGWGKLSAKLINGIRDK QTGKTILEYLI DDG DCNRNFMQLINDDGL 701

WP_009729476 634 QRLAQYDSLFDEKVIKALTR RHYTGWGKLSAKLINGISDK QTGNTILDYLI DDG EINRNFMQLINDDGL 702

CQR24647 637 QRLLKYEDIFSKKVIANLTR RHYTGWGRLSAKLINGIKDK HSRKTILDYLI DDG HSNRNFMQLINDDNL 705

WP_000066813 636 QRLAQYDSLFDEKVIKALTR RHYTGWGKLSAKLINGIRDK KSGKTILDYLI DDG EINRNFMQLIHDDGL 704

WP_009754323 634 QRLAQYDSIFDEKVIKALTR RHYTGWGKLSAKLINGICDK KTGKTILDYLI DDG YNNRNFMQLINDDGL 702

WP_044674937 633 KRLEKYKDILTEEQRKKLER RHYTGWGRLSAKLINGILDK VTRKTILGYLI DDG TSNRNFMQLINDDTL 701

WP_044676715 635 KRLEKYKDVLTEEQRKKLER RHYTGWGRLSAKLINGIRDK VTRKTILDYLI DDG TSNRNFMQLINDDTL 703

WP_044680361 635 KRLEKYKDVLTEEQRKKLER RHYTGWGRLSAKLINGIRDK VTRKTILDYLI DDG TSNRNFMQLINDDTL 703

WP_044681799 633 KRLEKYKDILTEEQRKKLER RHYTGWGRLSAKLINGILDK VTRKTILGYLI DDG TSNRNFMQLINDDTL 701

WP_049533112 635 QRLQKYSDIFTKAQLKKLER CHYTGWGRLSYKLINGIRNK ENKKTILDYLI DDG YANRNFMQLINDDAL 703

WP_029090905 613 RKLSEYPQLTEQQQVQLAQV -RFRGWGRLSQRLINRIKTP EDHKLSINEIL QTNENFMQIIRNKDY 682

WP 006506696 638 RRLKKKYALPDDKVKQILKL -KYKDWSRLSKKLLDGIVAD SV—TVLDVLE SRLNLMEIINDKDL 705

AIT42264 634 ERLKTYAHLFDDKVMKQLKR RRYTGWGRLSRKLINGIRDK QSGKTILDFLK -DGf ANRNFMQLIHDDSL 702

WP_034440723 638 RQLMKFKDKLSEKAINQLSK KHYTGWGQLSEKLINGIRDE QSNKTILDYLI DNGcpkNMNRNFMQLINDDTL 710

AKQ21048 634 ERLKTYAHLFDDKVMKQLKR RRYTGWGRLSRKLINGIRDK QSGKTILDFLK -DGf ANRNFMQLIHDDSL 702

WP_004636532 634 KQLQTYSDTLSPEILKKLER KHYTGWGRFSKKLINGLRDE GSNKTILDYLK DEGssgPTNRNFMQLIRDNTL 706

WP_002364836 642 TQLSTFKGQFSAEVLKKLER KHYTGWGRLSKKLINGIYDK ESGKTILGYLI DDGvs kHYNRNFMQLINDSQL 714

WP_016631044 593 TQLSTFKGQFSAEVLKKLER KHYTGWGRLSKKLINGIYDK ESGKTILDYLV DDGvs kHYNRNFMQLINDSQL 665

EMS75795 382 TQLKKYQSVLGDGFFKKLVK KHYTGWGRLSERLINGIRDK KTNKTILDYLI DDDfpyNRNRNFMQLINDDSL 454

WP 002373311 642 TQLSTFKGQFSAEVLKKLER KHYTGWGRLSKKLINGIYDK ESGKTILDYLV DDGvs kHYNRNFMQLINDSQL 714

WP ^"002378009 642 TQLSTFKGQFSAEVLKKLER KHYTGWGRLSKKLINGIYDK ESGKTILDYLI DDGvs kHYNRNFMQLINDSQL 714

WP ^"002407324 642 TQLSTFKGQFSAEVLKKLER KHYTGWGRLSKKLINGIYDK ESGKTILDYLV DDGvs kHYNRNFMQLINDSQL 714

WP ^"002413717 642 TQLSTFKGQFSAEVLKKLER KHYTGWGRLSKKLINGIYDK ESGKTILDYLV DDGvs kHYNRNFMQLINDSQL 714

WP ^"010775580 644 TQLSTFKGQFSEEVLKKLER KHYTGWGRLSKKLINGIYDK ESGKTILDYLI DDGvs kHYNRNFMQLINDSQL 716

WP ^"010818269 642 TQLSTFKGQFSAEVLKKLER KHYTGWGRLSKKLINGIYDK ESGKTILGYLI DDGvs kHYNRNFMQLINDSQL 714

WP 010824395 642 TQLSTFKGQFSAEVLKKLER- KHYTGWGRLSKKLINGIYDK ESGKTILDYLI DDGvs kHYNRNFMQLINDSQL 714

WP ^"016622645 642 TQLSTFKGQFSAEVLKKLER- KHYTGWGRLSKKLINGIYDK ESGKTILDYLV DDGvs kHYNRNFMQLINDSQL 714

WP ^"033624816 642 TQLSTFKGQFSAEVLKKLER-^■KHYTGWGRLSKKLINGIYDK ESGKTILDYLI DDGvs kHYNRNFMQLINDSQL 714

WP ^"033625576 642 TQLSTFKGQFSAEVLKKLER-^■KHYTGWGRLSKKLINGIYDK ESGKTILDYLI DDGvs kHYNRNFMQLINDSQL 714

WP ^"033789179 642 TQLSTFKGQFSEEVLKKLER-^■KHYTGWGRLSKKLINGIYDK ESGKTILDYLI DDGvs kHYNRNFMQLINDSQL 714

WP ^"002310644 642 TRLSHHEATLGKHIIKKLTK- KHYTGWGRLSKELIQGIRDK QSNKTILDYLI DDDfphHRNRNFMQLINDDSL 714

WP ^"002312694 643 TRLSHHEATLGKHIIKKLTK- KHYTGWGRLSKELIQGIRDK QSNKTILDYLI DDDfphHRNRNFMQLINDDSL 715

WP ^"002314015 643 TRLSHHEATLGKHIIKKLTK-^■KHYTGWGRLSKELIQGIRDK QSNKTILDYLI DDDfphHRNRNFMQLINDDSL 715

WP ^"002320716 643 TRLSHHEATLGKHIIKKLTK-^■KHYTGWGRLSKELIQGIRDK QSNKTILDYLI DDDfphHRNRNFMQLINDDSL 715

WP ^"002330729 642 TRLSHHEATLGKHIIKKLTK-^■KHYTGWGRLSKELIQGIRDK QSNKTILDYLI DDDfphHRNRNFMQLINDDSL 714

WP ^"002335161 643 TRLSHHEATLGKHIIKKLTK-^■KHYTGWGRLSKELIQGIRDK QSNKTILDYLI DDDfphHRNRNFMQLINDDSL 715

WP ^"002345439 643 TRLSHHEATLGKHIIKKLTK-^■KHYTGWGRLSKELIQGIRDK QSNKTILDYLI DDDfphHRNRNCMQLINDDSL 715

WP ^"034867970 638 HQLSKYQEVFGEKLLKEFAR- KHYTGWGRFSAKLIHGIRDR KTNKTILDYLI DDDvpaNRNRNLMQLINDEHL 710

WP ^"047937432 643 TRLSHHEATLGKHIIKKLTK-^■KHYTGWGRLSKELIQGIRDK QSNKTILDYLI DDDfphHRNRNFMQLINDDSL 715

WP ^"010720994 638 HQLSKYQEVFGEKLLKEFAR-^■KHYTGWGRFSAKLIHGIRDR KTNKTILDYLI DDDvpaNRNRNLMQLINDEHL 710

WP ^"010737004 638 HQLSKYQEVFGEKLLKEFAR-^■KHYTGWGRFSAKLIHGIRDR KTNKTILDYLI DDDvpaNRNRNLMQLINDEHL 710

WP ^"034700478 638 HQLSKYQEVFGEKLLKEFAR-^■KHYTGWGRFSAKLIHGIRDR KTNKTILDYLI DDDvpaNRNRNLMQLINDEHL 710

WP ^"007209003 635 NQLEQLPLNLSTKTIKALSR- RKYTGWGRLSARLIDGIHDK NSGKTILDYLI DESdsylVNRNFMQLINDDHL 707

WP ^"023519017 632 EQLKPYETVLGLPAIKKLAK- KHYTGWGRLSEKMIQGMREK QSRKTILDYLI DDDfpcNRNRNFMQLINDDHL 704

WP ^"010770040 635 EQLKKYTYLFDEEVLKKLER- RHYTGWGRLSAKLLIGIKEK RTHKTILDYLI DDGgkqPINRNLMQLINDSDL 707

WP ^"048604708 631 EQLSKFSDRLSEKTIKDLER- RHYTGWGRLSAKLINGIHDK QSNKTILDYLI DDApkkNINRNFMQLINDNRL 703

WP ^"010750235 637 TQLKKYQRILGEEIFKKLVK- KKYTGWGRLSKRLINGIRDQ KTNKTILDYLI DDDfpyNRNRNFMQLINDDHL 709

AII16583 673 ERLKTYAHLFDDKVMKQLKR- RRYTGWGRLSRKLINGIRDK QSGKTILDFLK -DGf ANRNFMQLIHDDSL 741

WP_029073316 648 RRLKKEYDLDEEKIKKILKL- -KYSGWSRLSKKLLSGIKTK RTPETVLEVME TNMNLMQVINDEKL 717

WP_031589969 648 RRLKKEYDLDEEKIKKILKL- -KYSGWSRLSKKLLSGIKTK RTPETVLEVME TNMNLMQVINDEKL 717

KDA45870 631 RRLENYRDFLGEDILRKLSR- KKYTGWGRLSAKLLDGIYDK KTHKTILDCLM EDYs QNFMQLINDDTY 698

WP_039099354 651 AKLNEIDWLTDQQRVQLAAK- -RYRGWGRLSAKLLTQIVN- ANGQRIMDLLW TTDNFMRIVHSE— 712

AKP02966 633 EKLHSSNYSYTSDQIKKISN- MRYKGWGRLSKKILTCITTE TNTPKSLQLSN -DLm-wTTNNNFI SI I SNDKY 706

WP_010991369 638 EQLQQFSDVLDGWLKKLER- RHYTGWGRLSAKLLMGIRDK QSHLTILDYLM DDG LNRNLMQLINDSNL 706

WP_033838504 638 EQLQQFSDVLDGWLKKLER- RHYTGWGRLSAKLLMGIRDK QSHLTILDYLM DDG LNRNLMQLINDSNL 706

EHN60060 641 EQLQQFSDVLDGWLKKLER-^■RHYTGWGRLSAKLLMGIRDK QSHLTILDYLM DDG LNRNLMQLINDSNL 709

EFR89594 407 EQLQQFSDVLDGWLKKLER-^■RHYTGWGRLSAKLLMGIRDK QSHLTILDYLM DDG LNRNLMQLINDSNL 475

WP_038409211 638 EQLQSFSDVLDGTILKKLER- RHYTGWGRLSAKLLTGIRDK HSHLTILDYLM DDG LNRNLMQLINDSNL 706

EFR95520 257 EQLQSFSDVLDGTILKKLER- RHYTGWGRLSAKLLTGIRDK HSHLTILDYLM DDG LNRNLMQLINDSNL 325

WP_003723650 638 EQLQQFSDVLDGGVLKKLER- RHYTGWGRLSAKLLVGIREK QSHLTILDYLM DDG LNRNLMQLINDSNL 706

WP_003727705 638 EQLEQFSDVLDGWLKKLER- RHYTGWGRLSAKLLVGIRDK QSHLTILDYLM DDG LNRNLMQLINDSNL 706

WP_003730785 638 EQLEQFSDVLDGWLKKLER- RHYTGWGRLSAKLLVGIRDK QSHLTILDYLM DDG LNRNLMQLINDSNL 706

WP_003733029 638 EQLQQFSDVLDGWLKKLER-^■RHYTGWGRLSAKLLVGIRDK QSHLTILDYLM DDG LNRNLMQLINDSNL 706

WP 003739838 638 EQLQQFSDVLDGAVLKKLER-^■RHYTGWGRLSAKLLVGIRDK QSHLTILDYLM DDG LNRNLMQLINDSNL 706

WP_014601172 638 EQLQQFSDVLDGGVLKKLER-RHYTGWGRLSAKLLVGIREK QSHLTILDYLM DDG——LNRNLMQLINDSNL 706

WP_023548323 638 EQLQQFSDVLDGTVLKKLER-RHYTGWGRLSAKLLVGIRDK QSHLTILDYLM DDG— —LNRNLMQLINDSNL 706

WP_031665337 638 EQLQQFSDVLDGWLKKLER-RHYTGWGRLSAKLLVGIRDK QSHLTILEYLM DDG— —LNRNLMQLINDSNL 706

WP_031669209 638 EQLQQFSDVLDGTVLKKLER-RHYTGWGRLSAKLLVGIRDK QSHLTILDYLM DDG— —LNRNLMQLINDSNL 706

WP_033920898 638 EQLQQFSDVLDGTVLKKLER-RHYTGWGRLSAKLLVGIRDK QSHLTILDYLM DDG— —LNRNLMQLINDSNL 706

AKI42028 641 EQLQQFSDVLDGGVLKKLER-RHYTGWGRLSAKLLVGIREK QSHLTILDYLM DDG— —LNRNLMQLINDSNL 709

AKI50529 641 EQLQQFSDVLDGTVLKKLER-RHYTGWGRLSAKLLVGIRDK QSHLTILDYLM DDG— —LNRNLMQLINDSNL 709

EFR83390 86 EQLQQFSDVLDGWLKKLER-RHYTGWGRLSAKLLVGIRDK QSHLTILEYLM DDG— —LNRNLMQLINDSNL 154

WP_046323366 638 ERLQEFSNVLDEAVLKKLER-RHYTGWGRLSAKLLIGIRDK ESHLTILDYLM DDK— —HNRNLMQLINDSNL 706

AKE81011 650 ERLKTYAHLFDDKVMKQLKR-RRYTGWGRLSRKLINGIRDK QSGKTILDFLK -DGf- —ANRNFMQLIHDDSL 718

CU082355 642 RRLKKKYALPDDKIKQILKL--KYKDWSRLSKKLLDGIVAD SV—TVLDVLE —SRLNLMEIINDKEL 709

WP_033162887 645 RRLKKVYQLDDLLVDKILKL--NYTGWSRLSEKLLTGMTAD KA—TVLFVLE —SNKNLMEI INDEKL 712

AGZ01981 667 ERLKTYAHLFDDKVMKQLKR-RRYTGWGRLSRKLINGIRDK QSGKTILDFLK -DGf- —ANRNFMQLIHDDSL 735

AKA60242 634 ERLKTYAHLFDDKVMKQLKR-RRYTGWGRLSRKLINGIRDK QSGKTILDFLK -DGf- —ANRNFMQLIHDDSL 702

AKS40380 634 ERLKTYAHLFDDKVMKQLKR-RRYTGWGRLSRKLINGIRDK QSGKTILDFLK -DGf- —ANRNFMQLIHDDSL 702

4UN5 B 638 ERLKTYAHLFDDKVMKQLKR-RRYTGWGRLSRKLINGIRDK QSGKTILDFLK -DGf- —ANRNFMQLIHDDSL 706

WP 010922251 703 TFKEDIQKAQVSG- -QG|DS-LHEHIANLAGSPAIKKGILQTVKWDELVKVMGrHKPENIVIEMA|RENQ TTQKGQKNS 777

WP ^"039695303 707 PFKQIIQKSQWG- -DVDD-1EAWHDLPGSPAIKKGILQSVKIVDELVKVMG-GNPDNIVIEMARENQ TTNRGRSQS 780

WP ^"045635197 702 SFKEIIQKAQVIG- -KTDD-VKQWQELSGSPAIKKGILQSIKIVDELVKVMG-HAPESIVIEMARENQ TTARGKKNS 775

5AXW A 427 VPKKVDLSQQKEI- -—PT TLVDDFILSPWKRSFIQSIKVINAIIKKYG—LPNDIIIELAREKN S 487

WP 009880683 387 TFKEDLQKAQVSG- -QGDS-LHEHIANLAGSPAIKKGILQTVKWDELVKVMGrHKPENIVIEMARENQ TTQKGQKNS 461

WP ^"010922251 703 TFKEDIQKAQVSG- -QGDS-LHEHIANLAGSPAIKKGILQTVKWDELVKVMGrHKPENIVIEMARENQ TTQKGQKNS 777

WP ^"011054416 703 TFKEDIQKAQVSG- -QGDS-LHEHIANLAGSPAIKKGILQTVKWDELVKVMGrHKPENIVIEMARENQ TTQKGQKNS 777

WP ^"011284745 703 TFKEDIQKAQVSG- -QGDS-LHEHIANLAGSPAIKKGILQTVKWDELVKVMGrHKPENIVIEMARENQ TTQKGQKNS 777

WP ^"011285506 703 TFKEDIQKAQVSG- -QGDS-LHEHIANLAGSPAIKKGILQTVKWDELVKVMGrHKPENIVIEMARENQ TTQKGQKNS 777

WP ^"011527619 703 TFKEDIQKAQVSG- -QGDS-LHEHIANLAGSPAIKKGILQTVKWDELVKVMGrHKPENIVIEMARENQ TTQKGQKNS 777

WP ^"012560673 703 TFKEDLQKAQVSG- -QGDS-LHEHIANLAGSPAIKKGILQTVKWDELVKVMGrHKPENIVIEMARENQ TTQKGQKNS 777

WP ^"014407541 703 TFKEDIQKAQVSG- -QGHS-LHEQIANLAGSPAIKKGILQTVKIVDELVKVMG-HKPENIVIEMARENQ TTQKGQKNS 776

WP ^"020905136 703 TFKEDIQKAQVSG- -QGDS-LHEHIANLAGSPAIKKGILQTVKWDELVKVMGrHKPENIVIEMARENQ TTQKGQKNS 777

WP ^"023080005 703 TFKEAIQKAQVSG- -QGHS-LHEQIANLAGSPAIKKGILQTVKIVDELVKVMG-HKPENIVIEMARENQ TTQKGQKNS 776

WP ^"023610282 703 TFKEAIQKAQVSG- -QGHS-LHEQIANLAGSPAIKKGILQTVKIVDELVKVMG-HKPENIVIEMARENQ TTQKGQKNS 776

WP ^"030125963 703 TFKEDLQKAQVSG- -QGDS-LHEHIANLAGSPAIKKGILQTVKWDELVKVMGrHKPENIVIEMARENQ TTQKGQKNS 777

WP ^"030126706 703 TFKEDIQKAQVSG- -QGDS-LHEHIANLAGSPAIKKGILQTVKWDELVKVMGrHKPENIVIEMARENQ TTQKGQKNS 777

WP ^"031488318 703 TFKEDIQKAQVSG- -QGDS-LHEHIANLAGSPAIKKGILQTVKWDELVKVMGrHKPENIVIEMARENQ TTQKGQKNS 777

WP ^"032460140 703 TFKEDLQKAQVSG- -QGDS-LHEHIANLAGSPAIKKGILQTVKWDELVKVMGrHKPENIVIEMARENQ TTQKGQKNS 777

WP ^"032461047 703 TFKEDLQKAQVSG- -QGDS-LHEHIANLAGSPAIKKGILQTVKWDELVKVMGrHKPENIVIEMARENQ TTQKGQKNS 777

WP ^"032462016 703 TFKEDIQKAQVSG- -QGDS-LHEHIANLAGSPAIKKGILQTVKWDELVKVMGrHKPENIVIEMARENQ TTQKGQKNS 777

WP ^"032462936 703 TFKEDIQKAQVSG- -QGDS-LHEHIANLAGSPAIKKGILQTVKWDELVKVMGrHKPENIVIEMARENQ TTQKGQKNS 777

WP ^"032464890 703 TFKEDIQKAQVSG- -QGDS-LHEHIANLAGSPAIKKGILQTVKWDELVKVMGrHKPENIVIEMARENQ TTQKGQKNS 777

WP ^"033888930 528 TFKEDIQKAQVSG- -QGDS-LHEHIANLAGSPAIKKGILQTVKWDELVKVMGrHKPENIVIEMARENQ TTQKGQKNS 602

WP ^"038431314 703 TFKEDIQKAQVSG- -QGDS-LHEHIANLAGSPAIKKGILQTVKWDELVKVMGrHKPENIVIEMARENQ TTQKGQKNS 777

WP ^"038432938 703 TFKEAIQKAQVSG- -QGHS-LHEQIANLAGSPAIKKGILQTVKIVDELVKVMG-HKPENIVIEMARENQ TTQKGQKNS 776

WP ^"038434062 703 TFKEDIQKAQVSG- -QGDS-LHEHIANLAGSPAIKKGILQTVKIVDELVKVMGrHKPENIVIEMARENQ TTQKGQKNS 777

BAQ51233 614 TFKEDIQKAQVSG- -QGDS-LHEHIANLAGSPAIKKGILQTVKWDELVKVMGrHKPENIVIEMARENQ TTQKGQKNS 688

KGE60162

KGE60856

WP 002989955 703 TFKEDIQKAQVSG- ^■QGDS -LHEHIANLAGSPAI KKGILQTVKWDELVKVMGrHKPENIVIEMARENQ TTQKGQKNS 777

WP ^"003030002 704 SFKEEIARAQIIG- ^■DVDD -IANWHDLPGSPAIKKGILQSVKIVDELVKVMG-HNPANI I IEMARENQ MTDKGRRNS 777

WP ^"003065552 707 PFKQIIQKSQWG- ^■DVDD -IEAWHDLPGSPAIKKGILQSVKIVDELVKVMG-DNPDNIVIEMARENQ TTNRGRSQS 780

WP ^"001040076 702 SFKPIIDKARTGS- ^■HSDN -LKEVIGELAGSPAIKKGILQSLKIVDELVKVMG-YEPEQIWEMARENQ TTAKGLSRS 775

WP ^"001040078 705 SFKSIISKAQAGS- ^■HSDN -LKEWGELAGSPAIKKGILQSLKIVDELVKVMG-YEPEQIWEMARENQ TTNQGRRNS 778

WP ^"001040080 705 SFKSIISKAQAGS- ^■HSDN -LKEWGELAGSPAIKKGILQSLKIVDELVKVMG-YEPEQIWEMARENQ TTNQGRRNS 778

WP ^"001040081 705 SFKSIISKAQAGS- ^■HSDN -LKEWGELAGSPAIKKGILQSLKIVDELVKVMG-YEPEQIWEMARENQ TTNQGRRNS 778

WP ^"001040083 705 SFKSIISKAQAGS- ^■HSDN -LKEWGELAGSPAIKKGILQSLKIVDELVKVMG-YEPEQIWEMARENQ TTNQGRRNS 778

WP ^"001040085 705 SFKSIISKAQAGS- ^■HSDN -LKEWGELAGSPAIKKGILQSLKIVDELVKVMG-YEPEQIWEMARENQ TTNQGRRNS 778

WP 001040087 705 SFKSIISKAQAGS--HSDN-^■LKEWGELAGSPAIKKGILQSLKIVDELVKVMG--YEPEQIWEMARENQ TTNQGRRNS 778

WP ^"001040088 705 SFKSIISKAQAGS- -HSDN- ^■LKEWGELAGSPAIKKGILQSLKIVDELVKVMG- -YEPEQIWEMARENQ TTNQGRRNS 778

WP ^"001040089 705 SFKSIISKAQAGS- -HSDN- ^■LKEWGELAGSPAIKKGILQSLKIVDELVKVMG- -YEPEQIWEMARENQ TTNQGRRNS 778

WP ^"001040090 705 SFKSIISKAQAGS- -HSDN- ^■LKEWGELAGSPAIKKGILQSLKIVDELVKWG- -YEPEQIWEMARENQ TTNQGRRNS 778

WP ^"001040091 705 SFKSIISKAQAGS- -HSDN- ^■LKEWGELAGSPAIKKGILQSLKIVDELVKVMG- -YEPEQIWEMARENQ TTNQGRRNS 778

WP ^"001040092 705 SFKSIISKAQSGS- -HSDN- ^■LKEWGELAGSPAIKKGILQSLKIVDELVKVMG- -YEPEQIWEMARENQ TTNQGRRNS 778

WP ^"001040094 702 SFKPIIDKARTGS- -HSDN- ^■LKEWGELAGSPAIKKGILQSLKIVDELVKVMG- -YEPEQIWEMARENQ TTAKGLSRS 775

WP ^"001040095 702 SFKPIIDKARTGS- -HLDN- ^■LKEWGELAGSPAIKKGILQSLKIVDELVKVMG- -YEPEQIWEMARENQ TTAKGLSRS 775

WP ^"001040096 702 SFKPIIDKARTGS- -HLDN- ^■LKEWGELAGSPAIKKGILQSLKIVDELVKVMG- -YEPEQIWEMARENQ TTAKGLSRS 775

WP ^"001040097 702 SFKPIIDKARTGS- -HSDN- ^■LKEWGELAGSPAIKKGILQSLKIVDELVKVMG- -YEPEQIWEMARENQ TTAKGLSRL 775

WP ^"001040098 702 SFKPIIDKARTGS- -HSDN- ^■LKEWGELAGSPAIKKGILQSLKIVDELVKVMG- -YEPEQIWEMARENQ TTAKGLSRS 775

WP ^"001040099 702 SFKPIIDKARTGS- -HSDN- ^■LKEWGELAGSPAIKKGILQSLKIVDELVKVMG- -YEPEQIWEMARENQ TTAKGLSRS 775

WP ^"001040100 702 SFKPIIDKARTGS- -HSDN- ^■LKEWGELAGSPAIKKGILQSLKIVDELVKVMG- -YEPEQIWEMARENQ TTAKGLSRS 775

WP ^"001040104 705 SFKSIISKAQAGS- -HSDN- ^■LKEWGELAGSPAIKKGILQSLKIVDELVKVMG- -YEPEQIWEMARENQ TTNQGRRNS 778

WP ^"001040105 705 SFKSIISKAQAGS- -HSDN- ^■LKEWGELAGSPAIKKGILQSLKIVDELVKVMG- -YEPEQIWEMARENQ TTNQGRRNS 778

WP ^"001040106 705 SFKPIIDKAQAGS- -HSDN- ^■LKEWGELAGSPAIKKGILQSLKIVDELVKVMG- -YEPEQWVEMARENQ TTNQGRRNT 778

WP ^"001040107 705 SFKPIIDKAQAGS- -HSDN- ^■LKEWGELAGSPAIKKGILQSLKIVDELVKVMG- -YEPEQWVEMARENQ TTNQGRRNT 778

WP ^"001040108 705 SFKPIIDKAQAGS- -HSDN- ^■LKEWGELAGSPAIKKGILQSLKIVDELVKVMG- -YEPEQWVEMARENQ TTNQGRRNT 778

WP ^"001040109 705 SFKPIIDKAQAGS- -HSDN- ^■LKEWGELAGSPAIKKGILQSLKIVDELVKVMG- -YEPEQWVEMARENQ TTNQGRRNT 778

WP ^"001040110 705 SFKPIIDKAQAGS- -HSDN- ^■LKEWGELAGSPAIKKGILQSLKIVDELVKVMG- -YEPEQWVEMARENQ TTNQGRRNT 778

WP ^"015058523 705 SFKSIISKAQSGS- -HSDN- ^■LKEWGELAGSPAIKKGILQSLKIVDELVKVMG- -YEPEQIWEMARENQ TTNQGRRNS 778

WP ^"017643650 702 SFKPIIDKARTGS- -HSDN- ^■LKEWGELAGSPAIKKGILQSLKIVDELVKVMG- -YEPEQIWEMARENQ TTAKGLSRL 775

WP ^"017647151 705 SFKSIISKAQAGS- -HSDN- ^■LKEWGELAGSPAIKKGILQSLKIVDELVKVMG- -YEPEQIWEMARENQ TTNQGRRNS 778

WP ^"017648376 705 SFKSIISKAQAGS- -HSDN- ^■LKEWGELAGSPAIKKGILQSLKIVDELVKVMG- -YEPEQIWEMARENQ TTNQGRRNS 778

WP ^"017649527 705 SFKSIISKAQAGS- -HSDN- ^■LKEWGELAGSPAIKKGILQSLKIVDELVKVMG- -YEPEQIWEMARENQ TTNQGRRNS 778

WP ^"017771611 705 SFKPIIDKAQAGS- -HSDN- ^■LKEWGELAGSPAIKKGILQSLKIVDELVKVMG- -YEPEQWVEMARENQ TTNQGRRNT 778

WP ^"017771984 705 SFKSIISKAQAGS- -HSDN- ^■LKEWGELAGSPAIKKGILQSLKIVDELVKVMG- -YEPEQIWEMARENQ TTNQGRRNS 778

CFQ25032 705 SFKSIISKAQAGS- -HSDN- ^■LKEWGELAGSPAIKKGILQSLKIVDELVKVMG- -YEPEQIWEMARENQ TTNQGRRNS 778

CFV16040 705 SFKSIISKAQAGS- -HSDN- ^■LKEWGELAGSPAIKKGILQSLKIVDELVKVMG- -YEPEQIWEMARENQ TTNQGRRNS 778

KLJ37842 705 SFKSIISKAQAGS- -HSDN- ^■LKEWGELAGSPAIKKGILQSLKIVDELVKVMG- -YEPEQIWEMARENQ TTNQGRRNS 778

KLJ72361 705 SFKSIISKAQAGS- -HSDN- ^■LKEWGELAGSPAIKKGILQSLKIVDELVKVMG- -YEPEQIWEMARENQ TTNQGRRNS 778

KLL20707 719 SFKSIISKAQAGS- -HSDN- ^■LKEWGELAGSPAIKKGILQSLKIVDELVKVMG- -YEPEQIWEMARENQ TTNQGRRNS 792

KLL42645 705 SFKPIIDKAQAGS- -HSDN- ^■LKEWGELAGSPAIKKGILQSLKIVDELVKVMG- -YEPEQWVEMARENQ TTNKGRRNT 778

WP 047207273 705 SFKSIISKAQAGS- -HSDN- ^■LKEWGELAGSPAIKKGILQSLKIVDELVKVMG- -YEPEQIWEMARENQ TTNQGRRNS 778

WP ^"047209694 702 SFKPIIDKARTGS- -HSDN- ^■LKEWGELAGSPAIKKGILQSLKIVDELVKVMG- -YEPEQIWEMARENQ TTAKGLSRS 775

WP ^"050198062 705 SFKSIISKAQAGS- -HSDN- ^■LKEWGELAGSPAIKKGILQSLKIVDELVKVMG- -YEPEQIWEMARENQ TTNQGRRNS 778

WP ^"050201642 705 SFKSIISKAQAGS- -HSDN- ^■LKEWGELAGSPAIKKGILQSLKIVDELVKVMG- -YEPEQIWEMARENQ TTNQGRRNS 778

WP ^"050204027 705 SFKPIIDKAQAGS- -HSDN- ^■LKEWGELAGSPAIKKGILQSLKIVDELVKVMG- -YEPEQWVEMARENQ TTNQGRRNT 778

WP ^"050881965 705 SFKSIISKAQAGS- -HSDN- ^■LKEWGELAGSPAIKKGILQSLKIVDELVKVMG- -YEPEQIWEMARENQ TTNQGRRNS 778

WP 050886065 705 SFKSIISKAQAGS-^■HSDN--LKEWGELAGSPAIKKGILQSLKIVDELVKVMG- YEPEQIWEMARENQ TTNQGRRNS 778

AHN30376 705 SFKSIISKAQSGS- ^■HSDN--LKEWGELAGSPAIKKGILQSLKIVDELVKVMG- YEPEQIWEMARENQ TTNQGRRNS 778

EA078426 705 SFKSIISKAQAGS- ^■HSDN--LKEWGELAGSPAIKKGILQSLKIVDELVKVMG- YEPEQIWEMARENQ TTNQGRRNS 778

CCW42055 705 SFKSIISKAQSGS- ^■HSDN--LKEWSELAGSPAIKKGILQSLKIVDELVKVMG- YKPEQIWEMARENQ TTNQGRRNS 778

WP 003041502 704 SFKEEIAKAQIIG- ^■DVDD--IANWHDLPGSPAIKKGILQSVKIVDELVKVMG- HNPANIIIEMARENQ TTDRGRRNS 777

WP 037593752 705 SFKEEIARAQIIG- ^■DVDD--IANWHDLPGSPAIKKGILQSVKIVDELVKVMG- HNPANIIIEMARENQ TTDKGRRNS 778

WP 049516684 705 SFKEEIARAQIIG- ^■DVDD--IANWHDLPGSPAIKKGILQSVKIVDELVKVMG- HNPANIIIEMARENQ TTDKGRRNS 778

GAD46167 704 SFKEEIARAQIIG- ^■DVDD--IANWHDLPGSPAIKKGILQSVKIVDELVKVMG- HNPANIIIEMARENQ TTDKGRRNS 777

WP 018363470 705 SFKQIIQEAQWG- ^■DVDD--IETWHDLPGSPAIKKGILQSVKIVDELIKVMG- DNPDNIVIEMARENQ TTNRGRSQS 778

WP 003043819 713 TFKEEIEKAQVSG- ^■QGDS--LHEQIADLAGSPAIKKGILQTVKIVDELVKVMG- HKPENIVIEMARENQ TTTKGLQQS 786

WP 006269658 704 SFKEEIARAQIID- ^■DVDD--IANWHDLPGSPAIKKGILQSVKIVDELVKVMG- HNPANIIIEMARENQ TTDKGRRNS 777

WP 048800889 704 PFKQIIKDAQAID- ^■DVDD--IELIVHDLPGSPAIKKGILQSIKIVDELVKVMG- YNPDNIVIEMARENQ TTTKGRRNS 777

WP 012767106 703 TFKEAIQKAQVSG- ^■QGHS--LHEQIANLAGSPAIKKGILQSVKWDELVKVMG- HKPENIVIEMARENQ TTQKGQKNS 776

WP 014612333 703 TFKEAIQKAQVSG- ^■QGHS--LHEQIANLAGSPAIKKGILQSVKWDELVKVMG- HKPENIVIEMARENQ TTQKGQKNS 776

WP 015017095 703 TFKEAIQKAQVSG- ^■QGHS--LHEQIANLAGSPAIKKGILQSVKWDELVKVMG- HKPENIVIEMARENQ TTQKGQKNS 776

WP 015057649 703 TFKEAIQKAQVSG- ^■QGHS--LHEQIANLAGSPAIKKGILQSVKWDELVKVMG- HKPENIVIEMARENQ TTQKGQKNS 776

WP 048327215 703 TFKEAIQKAQVSG- ^■QGHS--LHEQIANLAGSPAIKKGILQSVKWDELVKVMG- HKPENIVIEMARENQ TTQKGQKNS 776

WP 049519324 703 TFKEAIQKAQVSG- ^■QGHS--LHEQIANLAGSPAIKKGILQSVKWDELVKVMG- HKPENIVIEMARENQ TTQKGQKNS 776

WP 012515931 703 SFIDEIAKAQVIG- ^■KTEY--SKDLVGNLAGSPAIKKGISQTIKIVDELVKIMG- YLPQQIVIEMARENQ TTAQGIKNA 776

WP 021320964 703 SFIDEIAKAQVIG- ^■KTEY--SKDLVGNLASSPAIKKGISQTIKIVDELVKIMG- YLPQQIVIEMARENQ TTAQGIKNA 776

WP 037581760 703 SFIDEIAKAQVIG- ^■KTEY--SKDLVGNLAGSPAIKKGISQTIKIVDELVKIMG- YLPQQIVIEMARENQ TTAQGIKNA 776

WP 004232481 704 SFKTTIQEAQWG- ^■DVDD--IEAWHDLPGSPAIKKGILQSVKIVDELVKVMG- HNPQNIVIEMARENQ ITGYGRNRS 777

WP 009854540 705 PFKQIIQKSQWG- ^■DVDD--IEAWHDLPGSPAIKKGILQSVKIVDELVKVMG- DNPDNIVIEMARENQ TTNRGRSQS 778

WP 012962174 705 PFKQIIKDAQIIG- ^■DIDD--VTSWRELPGSPAIKKGILQSVKIVDELVKVMG- HNPDNIVIEMARENQ TTNRGRNQS 778

WP 039695303 707 PFKQIIQKSQWG- ^■DVDD--IEAWHDLPGSPAIKKGILQSVKIVDELVKVMG- GNPDNIVIEMARENQ TTNRGRSQS 780

WP 014334983 704 SFKTIIQEAQWG- ^■DVDD--IEAWHDLPGSPAIKKGILQSVKIVDELVKVMG- DNPDNIVIEMARENQ TTGYGRNKS 777

WP 003099269 703 DFAKIIKNEQEKTi .KNES--LEETIANLAGSPAIKKGILQSIKIVDEIVKIMG- QNPDNIVIEMARENQ STMQGIKNS 777

AHY15608 703 DFAKIIKNEQEKTiKNES--LEETIANLAGSPAIKKGILQSIKIVDEIVKIMG- QNPDNIVIEMARENQ STMQGIKNS 777

AHY17476 703 DFAKIIKNEQEKTiKNES--LEETIANLAGSPAIKKGILQSIKIVDEIVKIMG- QNPDNIVIEMARENQ STMQGIKNS 777

ESR09100

AGM98575 703 DFAKIIKNEQEKTiKNES- -LEETIANLAGSPAIKKGILQS IKIVDEIVKIMG- QNPDNIVIEMARENQ STMQGIKNS 777

ALF27331 704 SFKEEIAKAQVIG- ^■ETDN--LNQWSDIAGSPAIKKGILQSLKIVDELVKIMG- HQPENIWEMARENQ FTNQGRRNS 777

WP 018372492 717 DFKEIIRKAQTIE- ^■NIDT--NQALVSSLPGSPAIKKGILQSLNIVDEI IAIMG- YAPTNIVIEMARENQ TTQKGRDNS 790

WP 045618028 703 SFKEIIQKAQWG- ^■KTND--VKQWQELPGSPAIKKGILQSIKLVDELVKVMG- HAPESIVIEMARENQ TTARGKKNS 776

WP 045635197 702 SFKEIIQKAQVIG- ^■KTDD--VKQWQELSGSPAIKKGILQSIKIVDELVKVMG- HAPESIVIEMARENQ TTARGKKNS 775

WP 002263549 704 SFKEEIAKAQVIG- ^■ETDN--LNQWSDIAGSPAIKKGILQSLKIVDELVKIMG- HQPENIWEMARENQ FTNQGRRNS 777

WP 002263887 704 SFKEEIAKAQVIG- ^■ETDN--LNQWSDIAGSPAIKKGILQSLKIVDELVKIMG- HQPENIWEMARENQ FTNQGRRNS 777

WP 002264920 704 SFKEEIAKAQVIG- ^■ETDN--LNQWSDIAGSPAIKKGILQSLKIVDELVKIMG- HQPENIWEMARENQ FTNQGRRNS 777

WP 002269043 704 SFKEEIAKAQVIG- ^■ETDN--LNQWSDIAGSPAIKKGILQSLKIVDELVKIMG- HQPENIWEMARENQ FTNQGRRNS 777

WP 002269448 704 SFKEEIAKAQVIG-^■ETDN-^■LNQWSDIAGSPAIKKGILQSLKIVDELVKIMG-^■HQPENIWEMARENQ FTNQGRQNS 777

WP ^"0022 71977 704 SFKEEIAKAQVIG- ^■ETDN- ^■LNQWSDIAGSPAIKKGILQSLKIVDELVKIMG- ^■HQPENIWEMARENQ FTNQGRRNS 777

WP ^"0022 72766 704 SFKEEIAKAQVIG- ^■ETDN- ^■LNQWSDIAGSPAIKKGILQSLKIVDELVKIMG- ^■HQPENIWEMARENQ FTNQGRRNS 777

WP ^"0022 73241 704 SFKEEIAKAQVIG- ^■ETDN- ^■LNQWSDIAGSPAIKKGILQSLKIVDELVKIMG- ^■HQPENIWEMARENQ FTKQGRRNS 777

WP ^"0022 75430 704 SFKEEIAKAQVIG- ^■ETDN- ^■LNQWSDIAGSPAIKKGILQSLKIVDELVKIMG- ^■HQPENIWEMARENQ FTNQGRRNS 777

WP ^"0022 76448 704 SFKEEIAKAQVIG- ^■ETDN- ^■LNQWSDIAGSPAIKKGILQSLKIVDELVKIMG- ^■HQPENIWEMARENQ FTKQGRRNS 777

WP ^"0022 77050 705 TFKDDIVKAQYVD- ^■NSDD- ^■LHQWQSLAGSPAIKKGILQSLKIVDELVKVMG- ^■KEPEQIWEMARENQ TTAKGRRNS 778

WP ^"0022 77364 704 SFKEEIAKAQVIG- ^■ETDN- ^■LNQWSDIAGSPAIKKGILQSLKIVDELVKIMG- ^■HQPENIWEMARENQ FTNQGRRNS 777

WP ^"0022 79025 704 SFKEEIAKAQVIG- ^■ETDN- ^■LNQWSDIAGSPAIKKGILQSLKIVDELVKIMG- ^■HQPENIWEMARENQ FTNQGRRNS 777

WP ^"0022 79859 704 SFKEEIAKAQVIG- ^■ETDN- ^■LNQWSDIAGSPAIKKGILQSLKIVDELVKIMG- ^■HQPENIWEMARENQ FTNQGRRNS 777

WP ^"0022 80230 704 SFKEEIAKAQVIG- ^■ETDN- ^■LNQWSDIAGSPAIKKGILQSLKIVDELVKIMG- ^■HQPENIWEMARENQ FTKQGRRNS 777

WP ^"0022 81696 704 SFKEEIAKAQVIG- ^■ETDN- ^■LNQWSDIAGSPAIKKGILQSLKIVDELVKIMG- ^■HQPENIWEMARENQ FTNQGRRNS 777

WP ^"0022 82247 705 TFKDDIVKAQYVD- ^■NSDD- ^■LHQWQSLAGSPAIKKGILQSLKIVDELVKVMG- ^■KEPEQIWEMARENQ TTAKGRRNS 778

WP ^"0022 82906 704 SFKEEIAKAQVIG- ^■ETDN- ^■LNQWSDIAGSPAIKKGILQSLKIVDELVKIMG- ^■HQPENIWEMARENQ FTNQGRRNS 777

WP ^"0022 83846 704 SFKEEIAKAQVIG- ^■ETDN- ^■LNQWSDIAGSPAIKKGILQSLKIVDELVKIMG- ^■HQPENIWEMARENQ FTNQGRRNS 777

WP ^"0022 87255 704 SFKEEIAKAQVIG- ^■ETDN- ^■LNQWSDIAGSPAIKKGILQSLKIVDELVKIMG- ^■HQPENIWEMARENQ FTNQGRRNS 777

WP ^"0022 88990 704 SFKEEIAKAQVIG- ^■ETDN- ^■LNQWSDIAGSPAIKKGILQSLKIVDELVKIMG- ^■HQPENIWEMARENQ FTNQGRRNS 777

WP ^"0022 89641 704 SFKEEIAKAQVIG- ^■ETDN- ^■LNQWSDIAGSPAIKKGILQSLKIVDELVKIMG- ^■HQPENIWEMARENQ FTNQGRRNS 777

WP ^"0022 90427 704 SFKEEIAKAQVIG- ^■ETDN- ^■LNQWSDIAGSLAIKKGILQSLKIVDELVKIMG- ^■HQPENIWEMARENQ FTNQGRRNS 777

WP ^"0022 95753 704 SFKEEIAKAQVIG- ^■ETDN- ^■LNQWSDIAGSPAIKKGILQSLKIVDELVKIMG- ^■HQPENIWEMARENQ FTKQGRRNS 777

WP ^"0022 96423 704 SFKEEIAKAQVIG- ^■ETDN- ^■LNQWSDIAGSPAIKKGILQSLKIVDELVKIMG- ^■HQPENIWEMARENQ FTNQGRRNS 777

WP ^"0023 04487 714 SFKEEIAKAQVIG- ^■EMDG- ^■LNQWSDIAGSPAIKKGILQSLKIVDELVKVMG- ^■HNPANIVIEMARENQ TTAKGRRSS 787

WP ^"0023 05844 704 SFKEEIAKAQVIG- ^■ETDN- ^■LNQWSDIAGSPAIKKGILQSLKIVDELVKIMG- ^■HQPENIWEMARENQ FTKQGRRNS 777

WP ^"0023 07203 704 SFKEEIAKAQVIG- ^■ETDN- ^■LNQWSDIAGSPAIKKGILQSLKIVDELVKIMG- ^■HQPENIWEMARENQ FTNQGRRNS 777

WP ^"0023 10390 704 SFKEEIAKAQVIG- ^■ETDN- ^■LNQWSDIAGSLAIKKGILQSLKIVDELVKIMG- ^■HQPENIWEMARENQ FTNQGRRNS 777

WP ^"0023 52408 704 SFKEEIAKAQVIG- ^■ETDN- ^■LNQWSDIAGSPAIKKGILQSLKIVDELVKIMG- ^■HQPENIWEMARENQ FTNQGQRNS 777

WP ^"0129 97688 704 SFKEEIAKAQVIG- ^■ETDN- ^■LNQWSDIAGSPAIKKGILQSLKIVDELVKIMG- ^■HQPENIWEMARENQ FTNQGRRNS 777

WP ^"θ146 77909 704 SFKEEIAKAQVIG- ^■ETDN- ^■LNQWSDIAGSPAIKKGILQSLKIVDELVKIMG- ^■HQPENIWEMARENQ FTNQGRRNS 777

WP ^"0193 12892 704 SFKEEIAKAQVIG- ^■ETDN- ^■LNQWSDIAGSPAIKKGILQSLKIVDELVKIMG- ^■HQPENIWEMARENQ FTNQGRRNS 777

WP ^"0193 13659 704 SFKEEIAKAQVIG- ^■ETDN- ^■LNQWSDIAGSPAIKKGILQSLKIVDELVKIMG- ^■HQPENIWEMARENQ FTNQGRRNS 777

WP ^"0193 14093 704 SFKEEIAKAQVIG- ^■ETDN- ^■LNQWSDIAGSPAIKKGILQSLKIVDELVKIMG- ^■HQPENIWEMARENQ FTNQGRRNS 777

WP ^"0193 15370 704 SFKEEIAKAQVIG- ^■ETDN- ^■LNQWSDIAGSPAIKKGILQSLKIVDELVKIMG- ^■HQPENIWEMARENQ FTNQGRRNS 777

WP ^"0198 03776 704 SFKEEIAKAQVIG- ^■ETDN- ^■LNQWSDIAGSPAIKKGILQSLKIVDELVKIMG- ^■HQPENIWEMARENQ FTNQGRRNS 777

WP ^"0198 05234 704 SFKEEIAKAQVIG- ^■ETDN- ^■LNQWSDIAGSLAIKKGILQNLKIVDELVKIMG- ^■HQPENIWEMARENQ FTNQGRRNS 777

WP ^"0247 83594 704 SFKEEIAKAQVIG- ^■ETDN- ^■LNQWSDIAGSPAIKKGILQSLKIVDELVKIMG- ^■HQPENIWEMARENQ FTNQGRRNS 777

WP ^"0247 84288 705 TFKDDIVKAQYVD- ^■NSDD- ^■LHQWQSLAGSPAIKKGILQSLKIVDELVKVMG- ^■KEPEQIWEMARENQ TTAKGRRNS 778

WP ^"0247 84666 704 SFKEEIAKAQVIG- ^■ETDN- ^■LNQWSDIAGSPAIKKGILQSLKIVDELVKIMG- ^■HQPENIWEMARENQ FTNQGRRNS 777

WP ^"0247 84894 704 SFKEEIAKAQVIG- ^■ETDN- ^■LNQWSDIAGSPAIKKGILQSLKIVDELVKIMG- ^■HQPENIWEMARENQ FTNQGRRNS 777

WP ^"0247 86433 705 TFKDDIVKAQYVD- ^■NSDD- ^■LHQWQSLAGSPAIKKGILQSLKIVDELVKVMG- ^■KEPEQIWEMARENQ TTAKGRRNS 778

WP_049473442 704 SFKEEIAKAQVIG-ETDN LNQWSDIAGSPAIKKGILQSLKIVDELVKIMG-HQPENIWEMARENQ FTNQGRRNS 777

WP_049474547 704 SFKEEIAKAQVIG-ETDN LNQWSDIAGSPAIKKGILQSLKIVDELVKIMG-HQPENIWEMARENQ FTNQGRRNS 777

EMC03581 697 SFKEEIAKAQVIG-ETDN LNQWSDIAGSPAIKKGILQSLKIVDELVKIMG-HQPENIWEMARENQ FTNQGRRNS 770

WP_000428612 705 SFKEIIKKAQWG-KTDD VKQWQELPGSPAIKKGILQSIKLVDELVKVMG-HEPESIVIEMARENQ TTARGKKNS 778

WP_000428613 703 SFKEITQKAQWG-KTDD VKQWQELPGSPAIKKGILQSIKIVDELVKVMG-HTPESIVIEMARENQ TTARGKKNS 776

WP_049523028 702 SFKETIQKAQWG-ETND VKQWQELPGSPAIKKGILQSIKIVDELVKVMG-HAPESWIEMARENQ TTNKGKSKS 775

WP_003107102 672 DFASIIKEAQEKTiKSEK LEETIANLAGSPAIKKGILQSVKIVDEWKVMG-YEPSNIVIEMARENQ STQRGINNS 746

WP_054279288 705 SFKEEIKKAQEGG-LKDS INDQIRDLAGSPAIKKGILQTINIVDEIVKIMG-KAPQHIWEMARDVQ KTDIGVKQS 778

WP_049531101 703 SFKEIIQESQWG-KPDD VKQIVQELPGSSAIKKGILQSIKLVDELVKVMG-HDPESIVIEMARENQ TTARGKKNS 776

WP_049538452 703 SFKEIIQKAQVFG-KTND VKQWQELPGSPAIKKGILQSIKIVEELVKVMG-HEPESIVIEMARENQ TTTRGKKNS 776

WP_049549711 703 SFKKIIQKSQWG-ETDD VKQWRELPGSPAIKKGILQSIKIVDELVKVMD-HAPESIVIEMARENQ TTARGKKNS 776

WP 007896501 706 DFEKLIDDAQKKAiKRES LTEAVANLAGSPAIKKGILQSLKWDEIVKVMG-HNPDNIVIEMSRENQ TTAQGLKNA 780

EFR44625 658 DFEKLIDDAQKKAiKRES LTEAVANLAGSPAIKKGILQSLKWDEIVKVMG-HNPDNIVIEMSRENQ TTAQGLKNA 732

WP_002897477 702 SFKEIIQKAQWG-KTDD VKQWQELPGSPAIKKGILQSIKIVDELVKVMG-YALESIVIEMARENQ TTARGKKNS 775

WP_002906454 702 SFKEIIQKAQWG-KTDD VKQWQEIPGSPAIKKGILQSIKIVDELVKVMG-HNPESIVIEMARENQ TTAKGKKNS 775

WP_009729476 703 SFKEIIQKAQWG-KTND VKQWQELPGSPAIKKGILQSIKIVDELVKVMG-HAPESIVIEMARENQ TTARGKKNS 776

CQR24647 706 SFKDEIANSQVIG-DGDD LHQWQELAGSPAIKKGILQSLKIVDELVKVMG-YNPEQIWEMARENQ TTARGRNNS 779

WP_000066813 705 SFKEIIQKAQVFG-KTND VKQWQELPGSPAIKKGILQSIKIVDELVKVMG-HAPESIVIEMARENQ TTARGKKNS 778

WP_009754323 703 SFKEIIQKAQWG-KTDD LTQWRELSGSPAIKKGILQSIKIVDELVKIMG-YAPESIVIEMARENQ TTAKGKKNS 776

WP_044674937 702 SFVDEIRLAQGSG-EAED YRAEVQNLAGSPAIKKGILQSLKIVDELIEVMG-YDPEHIWEMARENQ FTNQGRRNS 775

WP_044676715 704 SFVDEIRLAQGSG-EAED YRAEVQNLAGSPAIKKGILQSLKIVDELIEVMG-YDPEHIWEMARENQ FTNQGRRNS 777

WP_044680361 704 SFVDEIRLAQGSG-EAED YRAEVQNLAGSPAIKKGILQSLKIVDELIEVMG-YDPEHIWEMARENQ FTNQGRRNS 777

WP_044681799 702 SFVDEIRLAQGSG-EAED YRAEVQNLAGSPAIKKGILQSLKIVDELIEVMG-YDPEHIWEMARENQ FTNQGRRNS 775

WP_049533112 704 SFKEEIAKAQVIG-ETDD LNQWSDIAGSPAIKKGILQSLKIVDELVKVMG-YNPANIVIEMARENQ TTDKGRRNS 777

WP_029090905 683 LFKKIIEEQFENEtALLN -KQRIDELAASPANKKGIWQAIKIVKELEKVLQ-QPAENIFIEFARSDE ES KRS 752

WP 006506696 706 GYAQMIEEATSCPeDGKF TYEEVERLAGSPALKRGIWQSLQIVEEITKVMK-CRPKYIYIEFERSEE KERT 776

AIT42264 703 TFKEDIQKAQVSG-QGDS LHEHIANLAGSPAIKKGILQTVKWDELVKVMGrHKPENIVIEMARENQ TTQKGQKNS 777

WP_034440723 711 SFKEKIRKAQDIN-QVND IKEIVKDLPGSPAIKKGIYQSIRIVDEIIRKMK-DRPKNIVIEMARENQ TTQEGKNKS 784

AKQ21048 703 TFKEDIQKAQVSG-QGDS LHEHIANLAGSPAIKKGILQTVKWDELVKVMGrHKPENIVIEMARENQ TTQKGQKNS 777

WP_004636532 707 SFKKKIEDAQTIE-DTTH IYDTVAELPGSPAIKKGIRQALKIVEEIIDIIG-YEPENIWEMARESQ TTKKGKDLS 780

WP_002364836 715 SFKNAIQKAQSSE-HEET LSETVNELAGSPAIKKGIYQSLKIVDELVAIMG-YAPKRIWEMARENQ TTSTGKRRS 788

WP_016631044 666 SFKNAIQKAQSSE-HEET LSETVNELAGSPAIKKGIYQSLKIVDELVAIMG-YAPKRIWEMARENQ TTSTGKRRS 739

EMS75795 455 SFKEELANELALA-GNQS LLEWEALLGSPAIKKGIWQTLKIVEELIEIIG-YNPKNIWEMARENQ RT NRS 524

WP_002373311 715 SFKNAIQKAQSSE-HEET LSETVNELAGSPAIKKGIYQSLKIVDELVAIMG-YAPKRIWEMARENQ TTSTGKRRS 788

WP_002378009 715 SFKNAIQKAQSSE-HEET LSETVNELAGSPAIKKGIYQSLKIVDELVAIMG-YAPKRIWEMARENQ TTSTGKRRS 788

WP_002407324 715 SFKNAIQKAQSSE-HEET LSETVNELAGSPAIKKGIYQSLKIVDELVAIMG-YAPKRIWEMARENQ TTSTGKRRS 788

WP_002413717 715 SFKNAIQKAQSSE-HEET LSETVNELAGSPAIKKGIYQSLKIVDELVAIMG-YAPKRIWEMARENQ TTSTGKRRS 788

WP_010775580 717 SFKNAIQKAQSSE-HEET LSETVNELAGSPAIKKGIYQSLKIVDELVAIMG-YAPKRIWEMARENQ TTSTGKRRS 790

WP 010818269 715 SFKNAIQKAQSSE-HEET LSETVNELAGSPAIKKGIYQSLKIVDELVAIMG-YAPKRIWEMARENQ TTSTGKRRS 788

WP 010824395 715 SFKNAIQKAQSSE--HEET-^■LSET ELAGSPAIKKGIYQSLKIVDELVAIMG-^■YAPKRIWEMARENQ TTSTGKRRS 788

WP ^"016622645 715 SFKNAIQKAQSSE- -HEET- ^■LSET ELAGSPAIKKGIYQSLKIVDELVAIMG- ^■YAPKRIWEMARENQ TTSTGKRRS 78 8

WP ^"033624816 715 SFKNAIQKAQSSE- -HEET- ^■LSET ELAGSPAIKKGIYQSLKIVDELVAIMG- ^■YAPKRIWEMARENQ TTSTGKRRS 78 8

WP ^"033625576 715 SFKNAIQKAQSSE- -HEET- ^■LSET ELAGSPAIKKGIYQSLKIVDELVAIMG- ^■YAPKRIWEMARENQ TTSTGKRRS 78 8

WP ^"033789179 715 SFKNAIQKAQSSE- -HEET- ^■LSET ELAGSPAIKKGIYQSLKIVDELVAIMG- ^■YAPKRIWEMARENQ TTSTGKRRS 78 8

WP ^"002310644 715 SFKKEIKKAQMIT- -DTEN- ^■LEEIVKELTGSPAIKKGILQSLKIVDEIVGIMG- ^■YEPANIWEMARENQ TTGRGLKSS 78 8

WP ^"002312694 716 SFKKEIKKAQMIT- -DTEN- ^■LEEIVKELTGSPAIKKGILQSLKIVDEIVGIMG- ^■YEPANIWEMARENQ TTGRGLKSS 78 9

WP ^"002314015 716 SFKKEIKKAQMIT- -DTEN- ^■LEEIVKELTGSPAIKKGILQSLKIVDEIVGIMG- ^■YEPANIWEMARENQ TTGRGLKSS 78 9

WP ^"002320716 716 SFKKEIKKAQMIT- -DTEN- ^■LEEIVKELTGSPAIKKGILQSLKIVDEIVGIMG- ^■YEPANIWEMARENQ TTGRGLKSS 78 9

WP ^"002330729 715 SFKKEIKKAQMIT- -DTEN- ^■LEEIVKELTGSPAIKKGILQSLKIVDEIVGIMG- ^■YEPANIWEMARENQ TTGRGLKSS 78 8

WP ^"002335161 716 SFKKEIKKAQMIT- -DTEN- ^■LEEIVKELTGSPAIKKGILQSLKIVDEIVGIMG- ^■YEPANIWEMARENQ TTGRGLKSS 78 9

WP ^"002345439 716 SFKKEIKKAQMIT- -DTEN- ^■LEEIVKELTGSPAIKKGILQSLKIVDEIVGIMG- ^■YEPANIWEMARENQ TTGRGLKSS 78 9

WP ^"034867970 711 SFKEEIAKATVFS- -KHKS- ^■LVDVIQDLPGSPAIKKGIWQSLKIVEELIAIIG- ^■YKPKNIVIEMARENQ KT HRT 78 0

WP ^"047937432 716 SFKKEIKKAQMIT- -DTEN- ^■LEEIVKELTGSPAIKKGILQSLKIVDEIVGIMG- ^■YEPANIWEMARENQ TTGRGLKSS 78 9

WP ^"010720994 711 SFKEEIAKATVFS- -KHKS- ^■LVDVIQDLPGSPAIKKGIWQSLKIVEELIAIIG- ^■YKPKNIVIEMARENQ KT HRT 78 0

WP ^"010737004 711 SFKEEIAKATVFS- -KHKS- ^■LVDVIQDLPGSPAIKKGIWQSLKIVEELIAIIG- ^■YKPKNIVIEMARENQ KT HRT 78 0

WP ^"034700478 711 SFKEEIAKATVFS- -KHKS- ^■LVDVIQDLPGSPAIKKGIWQSLKIVEELIAIIG- ^■YKPKNIVIEMARENQ KT HRT 78 0

WP ^"007209003 708 SFKKIIEDSQPYK- -EQQS- ^■AEEIVSELSGSPAIKKGILQSLKIVDELVAIMG- ^■YKPKNIWEMARENQ TTGRGKQNS 78 1

WP ^"023519017 705 SFKETIANELIMS- -DSNV- ^■LLDQVKAIPGSPAVKKGIWQSIKIVEEIIGIIG- ^■KAPKNIVIEMARENQ RTSR S 774

WP ^"010770040 708 SFKSEIAEAQSDM- -NTED- ^■LHEWQNLAGSPAIKKGILQSLKIVDELVDIMG- ^■SLPKNIWEMARENQ TTSRGRTNS 78 1

WP ^"048604708 704 TFKEEIEKEQLKA- -NSEEsLIEIVQNLAGSPAIKKGIFQSLKIVDELVEIMG- ^■YAPTNIWEMARENQ TTANGRRNS 77 8

WP ^"010750235 710 SFKEEIAKELTLS- -DKQS- ^■LLEWEAIPGSPAIKKGIWQTLKIVEELIAIIG- ^■YKPKNIVIEMARENQ TTTGGKNRS 78 3

AII16583 742 TFKEDIQKAQVSG- -QGDS- ^■LHEHIANLAGSPAIKKGILQTVKWDELVKVMGrHKPENIVIEMARENQ TTQKGQKNS 816

WP 029073316 718 GFKKTIDDANSTSvSGKF- ^■SYAEVQELAGSPAIKRGIWQALLIVDEIKKIMK- ^■HEPAHVYIEFARNED KERK 78 8

WP ^"031589969 718 GFKKTIDDANSTSvSGKF- ^■SYAEVQELAGSPAIKRGIWQALLIVDEIKKIMK- ^■HEPAHVYIEFARNED KERK 78 8

KDA45870 699 SFKETIKNAQVIE- -KEET- ^■LAKTVQELPGSPAIKKGILQSLEIVDEIIKVMG- ^■YKPKSIWEMARETQ —THGTRKR 771

WP 039099354 713 DFDKLITEANQMM- -LAENdVQDVINDLYTSPQNKKALRQILLV DIQKAMKgQAPERILIEFAREDE VNPRLSVQR 78 8

AKP02966 707 DFKNYIENHNLNKnEDQN- ^■ISNLVNDIHVSPALKRGITQSIKIVQEIVKFMG- ^■HAPKYIFIEVTRETK TTSRGKRIQ 78 5

WP 010991369 707 SFKSIIEKEQVTT- -ADKD- ^■IQSIVADLAGSPAIKKGILQSLKIVDELVSVMG- ^■YPPQTIWEMARENQ TTGKGKNNS 78 0

WP ^"033838504 707 SFKSIIEKEQVTT- -ADKD- ^■IQSIVADLAGSPAIKKGILQSLKIVDELVSVMG- ^■YPPQTIWEMARENQ TTGKGKNNS 78 0

EHN60060 710 SFKSIIEKEQVTT- -ADKD- ^■IQSIVADLAGSPAIKKGILQSLKIVDELVSVMG- ^■YPPQTIWEMARENQ TTGKGKNNS 78 3

EFR89594 476 SFKSIIEKEQVTT- -ADKD- ^■IQSIVADLAGSPAIKKGILQSLKIVDELVSVMG- ^■YPPQTIWEMARENQ TTGKGKNNS 549

WP 038409211 707 SFKSIIEKEQVST- -ADKG- ^■IQSIVAELAGSPAIKKGILQSLKIVDELVGIMG- ^■YPPQTIWEMARENQ TTGKGKNNS 78 0

EFR95520 326 SFKSIIEKEQVST- -ADKG- ^■IQSIVAELAGSPAIKKGILQSLKIVDELVGIMG- ^■YPPQTIWEMARENQ TTGKGKNNS 399

WP 003723650 707 SFKSIIEKEQVST- -TDKD- ^■LQSIVAELAGSPAIKKGILQSLKIVDELVSIMG- ^■YPPQTIWEMARENQ TTGKGKNNS 78 0

WP ^"003727705 707 SFKSIIEKEQVST- -TDKD- ^■LQSIVADLAGSPAIKKGILQSLKIVDELVSIMG- ^■YPPQTIWEMARENQ TTGKGKNNS 78 0

WP ^"003730785 707 SFKSIIEKEQVST- -TDKD- ^■LQSIVADLAGSPAIKKGILQSLKIVDELVSIMG- ^■YPPQTIWEMARENQ TTGKGKNNS 78 0

WP ^"003733029 707 SFKSIIEKEQVST- -TDKD- ^■LQSIVAELAGSPAIKKGILQSLKIVDELVSVMG- ^■YPPQTIWEMARENQ TTNKGKNNS 78 0

WP ^"003739838 707 SFKSIIEKEQVST- -TDKD- ^■LQSIVADLAGSPAIKKGILQSLKIVDELVSIMG- ^■YPPQTIWEMARENQ TTVKGKNNS 78 0

WP 014601172 707 SFKSIIEKEQVST--TDKD-^■LQSIVADLAGSPAIKKGILQSLKIVDELVSIMG-YPPQTIWEMARENQ TTGKGKNNS 780

WP 023548323 707 SFKSIIEKEQVST- -ADKD- ^■LQSIVADLAGSPAIKKGILQSLKWEELVSVMG-YPPQTIWEMARENQ TTNKGKNNS 7 80

WP 031665337 707 SFKSIIEKEQVST- -TDKD- ^■LQSIVAELAGSPAIKKGILQSLKIVDELVSIMG-YPPQTIWEMARENQ TTGKGKNNS 7 80

WP 031669209 707 SFKSIIEKEQVST- -ADKD- ^■LQSIVADLAGSPAIKKGILQSLKIVDELVSVMG-YPPQTIWEMARENQ TTNKGKNNS 7 80

WP 033920898 707 SFKSIIEKEQVST- -ADKD- ^■LQSIVADLAGSPAIKKGILQSLKWEELVSVMG-YPPQTIWEMARENQ TTNKGKNNS 7 80

AKI42028 710 SFKSIIEKEQVST- -TDKD- ^■LQSIVADLAGSPAIKKGILQSLKIVDELVSIMG-YPPQTIWEMARENQ TTGKGKNNS 7 83

AKI50529 710 SFKSIIEKEQVST- -ADKD- ^■LQSIVADLAGSPAIKKGILQSLKWEELVSVMG-YPPQTIWEMARENQ TTNKGKNNS 7 83

EFR83390 155 SFKSIIEKEQVST- -TDKD- ^■LQSIVADLAGSPAIKKGILQSLKIVDELVSIMG-YPPQTIWEMARENQ TTVKGKNNS 228

WP 046323366 707 SFKSIIEKEQVST- -ADKD- ^■IQSIVADLAGSPAIKKGILQSLKIVDELVGIMG-YPPQTIWEMARENQ TTGKGKNNS 7 80

AKE81011 719 TFKEDIQKAQVSG- -QGDS- ^■LHEHIANLAGSPAIKKGILQTVKWDELVKVMGrHKPENIVIEMARENQ TTQKGQKNS 793

CU082355 710 GYAQMIEEASSCPkDGKF- ^■TYEEVAKLAGSPALKRGIWQSLQIVEEITKVMK-CRPKYIYIEFERSEE KERT 7 80

WP 033162887 713 GYKQIIEESNMQD: LEGPF- ^■KYDEVKKLAGSPAIKRGIWQALLWREITKFMK-HEPSHIYIEFAREEQ KVRK 7 83

AGZ 01981 736 TFKEDIQKAQVSG- -QGDS- ^■LHEHIANLAGSPAIKKGILQTVKWDELVKVMGrHKPENIVIEMARENQ TTQKGQKNS 8 10

AKA60242 703 TFKEDIQKAQVSG- -QGDS- ^■LHEHIANLAGSPAIKKGILQTVKWDELVKVMGrHKPENIVIEMARENQ TTQKGQKNS 777

AKS40380 703 TFKEDIQKAQVSG- -QGDS- ^■LHEHIANLAGSPAIKKGILQTVKWDELVKVMGrHKPENIVIEMARENQ TTQKGQKNS 777

4UN5 B 707 TFKEDIQKAQVSG- -QGDS- ^■LHEHIANLAGSPAIKKGILQTVKWDELVKVMGrHKPENIVIEMARENQ TTQKGQKNS 7 81

WP 010922251 778 RERMKRIEEGIK ELGS QILKEHP--VE-—NTQLQ EKLYLYYLQNGRDMYVDQEL--D--I RLSDYDVD|H|I 841

WP 039695303 781 QQRLKKLQNSLK PSYI E DK- -VE- —NSHLQNDQLFLYYIQNGKDMYTGDEL- -D- -IDHLSDYDIDHI 851

WP ^"045635197 776 QQRYKRIEDSLK ILAS NILKENP- -TD- —NNQLQNDRLFLYYLQNGKDMYTGEAL- -D- -INQLSSYDIDHI 843

5AXW A 488 KDAQKMINEMQK QTNE EIIRTTGk —E- —NAKYLIEKIKLHDMQEGKCLYSLEAIplEdlLNNPFNYEVDHI 561

WP 009880683 462 RERMKRIEEGIK ELGS DILKEYP- -VE- —NTQLQNEKLYLYYLQNGRDMYVDQEL- -D- -INRLSDYDVDHI 525

WP ^"010922251 778 RERMKRIEEGIK ELGS QILKEHP- -VE- —NTQLQNEKLYLYYLQNGRDMYVDQEL- -D- -INRLSDYDVDHI 841

WP ^"011054416 778 RERMKRIEEGIK ELGS DILKEYP- -VE- —NTQLQNEKLYLYYLQNGRDMYVDQEL- -D- -INRLSDYDVDHI 841

WP ^"011284745 778 RERMKRIEEGIK ELGS QILKEHP- -VE- —NTQLQNEKLYLYYLQNGRDMYVDQEL- -D- -INRLSDYDVDHI 841

WP ^"011285506 778 RERMKRIEEGIK ELGS QILKEHP- -VE- —NTQLQNEKLYLYYLQNGRDMYVDQEL- -D- -INRLSDYDVDHI 841

WP ^"011527619 778 RERMKRIEEGIK ELGS QILKEHP- -VE- —NTQLQNEKLYLYYLQNGRDMYVDQEL- -D- -INRLSDYDVDHI 841

WP ^"012560673 778 RERMKRIEEGIK ELGS DILKEYP- -VE- —TTQLQNEKLYLYYLQNGRDMYVDQEL- -D- -INRLSDYDVDHI 841

WP ^"014407541 777 RERMKRIEEGIK ELGS QILKEHP- -VE- —NTQLQNEKLYLYYLQNGRDMYVDQEL- -D- -INRLSDYDVDHI 840

WP ^"020905136 778 RERMKRIEEGIK ELGS QILKEHP- -VE- —NTQLQNEKLYLYYLQNGRDMYVDQEL- -D- -INRLSDYDVDHI 841

WP ^"023080005 777 RERMKRIEEGIK ELGS QILKEHP- -VE- —NTQLQNEKLYLYYLQNGRDMYVDQEL- -D- -INRLSDYDVDHI 840

WP ^"023610282 777 RERMKRIEEGIK ELGS QILKEHP- -VE- —NTQLQNEKLYLYYLQNGRDMYVDQEL- -D- -INRLSDYDVDHI 840

WP ^"030125963 778 RERMKRIEEGIK ELGS DILKEYP- -VE- —NTQLQNEKLYLYYLQNGRDMYVDQEL- -D- -INRLSDYDVDHI 841

WP ^"030126706 778 RERMKRIEEGIK ELGS DILKEYP- -VE- —NTQLQNEKLYLYYLQNGRDMYVDQEL- -D- -INRLSDYDVDHI 841

WP ^"031488318 778 RERMKRIEEGIK ELGS DILKEYP- -VE- —NTQLQNEKLYLYYLQNGRDMYVDQEL- -D- -INRLSDYDVDHI 841

WP ^"032460140 778 RERMKRIEEGIK ELGS DILKEYP- -VE- —NTQLQNEKLYLYYLQNGRDMYVDQEL- -D- -INRLSDYDVDHI 841

WP ^"032461047 778 RERMKRIEEGIK ELGS DILKEYP- -VE- —NTQLQNEKLYLYYLQNGRDMYVDQEL- -D- -INRLSDYDVDHI 841

WP ^"032462016 778 RERMKRIEEGIK ELGS QILKEHP- -VE- —NTQLQNEKLYLYYLQNGRDMYVDQEL- -D- -INRLSDYDVDHI 841

WP ^"032462936 778 RERMKRIEEGIK ELGS DILKEYP- -VE- —NTQLQNEKLYLYYLQNGRDMYVDQEL- -D- -INRLSDYDVDHI 841

WP ^"032464890 778 RERMKRIEEGIK ELGS QILKEHP- -VE- —NTQLQNEKLYLYYLQNGRDMYVDQEL- -D- -INRLSDYDVDHI 841

WP ^"033888930 603 RERMKRIEEGIK ELGS QILKEHP- -VE- —NTQLQNEKLYLYYLQNGRDMYVDQEL- -D- -INRLSDYDVDHI 666

WP ^"038431314 778 RERMKRIEEGIK ELGS DILKEYP- -VE- —NTQLQNEKLYLYYLQNGRDMYVDQEL- -D- -INRLSDYDVDHI 841

WP ^"038432938 777 RERMKRIEEGIK ELGS QILKEHP- -VE- —NTQLQNEKLYLYYLQNGRDMYVDQEL- -D- -INRLSDYDVDHI 840

WP ^"038434062 778 RERMKRIEEGIK ELGS DILKEYP- -VE- —NTQLQNEKLYLYYLQNGRDMYVDQEL- -D- -INRLSDYDVDHI 841

BAQ51233 689 RERMKRIEEGIK ELGS QILKEHP- -VE- —NTQLQNEKLYLYYLQNGRDMYVDQEL- -D- -INRLSDYDVDHI 752

KGE60162 1 -D- -INRLSGYDVDHI 16

KGE60856

WP 002989955 778 RERMKRIEEGIK ELGS QILKEHP- -VE- —NTQLQNEKLYLYYLQNGRDMYVDQEL- -D- -INRLSDYDVDHI 841

WP ^"003030002 778 QQRLKLLQDSLK PVNI K N- -VE- —NQQLQNDRLFLYYIQNGKDMYTGETL- -D- -INNLSQYDIDHI 840

WP ^"003065552 781 QQRLKKLQNSLK PSYI E DK- -VE- —NSHLQNDQLFLYYIQNGKDMYTGDEL- -D- -IDHLSDYDIDHI 851

WP ^"001040076 776 RQRLTTLRESLA NLKS EKKPKYV- -KDqveNHHLSDDRLFLYYLQNGKDMYTDDEL- -D- -IDNLSQYDIDHI 846

WP ^"001040078 779 RQRYKLLDDGVK NLAS NILKEYP- -TD- —NQALQNERLFLYYLQNGRDMYTGEAL- -D- -IDNLSQYDIDHI 846

WP ^"001040080 779 RQRYKLLDDGVK NLAS NILKEYP- -TD- —NQALQNERLFLYYLQNGRDMYTGEAL- -D- -IDNLSQYDIDHI 846

WP ^"001040081 779 RQRYKLLDDGVK NLAS NILKEYP- -TD- —NQALQNERLFLYYLQNGRDMYTGEAL- -D- -IDNLSQYDIDHI 846

WP ^"001040083 779 RQRYKLLDDGVK NLAS NILKEYP- -TD- —NQALQNERLFLYYLQNGRDMYTGEAL- -D- -IDNLSQYDIDHI 846

WP ^"001040085 779 RQRYKLLDDGVK NLAS NILKEYP- -TD- —NQALQNERLFLYYLQNGRDMYTGEAL- -D- -IDDLSQYDIDHI 846

WP 001040087 779 RQRYKLLDDGVK NLAS NILKEYP--TD-—NQALQNERLFLYYLQNGRDMYTGEAL--D--IDNLSQYDIDHI 846

WP ^"001040088 77 9 RQRYKLLDDGVK NLAS NILKEYP- -TD- —NQALQNERLFLYYLQNGRDMYTGEAL- -D- -IDNLSQYDIDHI 846

WP ^"001040089 77 9 RQRYKLLDDGVK NLAS NILKEYP- -TD- —NQALQNERLFLYYLQNGRDMYTGEAL- -D- -IDNLSQYDIDHI 846

WP ^"001040090 77 9 RQRYKLLDDGVK NLAS NILKEYP- -TD- —NQALQNERLFLYYLQNGRDMYTGEAL- -D- -IDNLSQYDIDHI 846

WP ^"001040091 77 9 RQRYKLLDDGVK NLAS NILKEYP- -TD- —NQALQNERLFLYYLQNGRDMYTGEAL- -D- -IDNLSQYDIDHI 846

WP ^"001040092 77 9 RQRYKLLEDGVK NLAS DILKEYP- -TD- —NQALQNERLFLYYLQNGRDMYTGEAL- -D- -IDNLSQYDIDHI 846

WP ^"001040094 77 6 RQRLTTLRESLA NLKS EKKPKYV- -KDqveNHHLSDDRLFLYYLQNGKDMYTDDEL- -D- -IDNLSQYDIDHI 846

WP ^"001040095 77 6 RQRLTTLRESLA NLKS EKKPKYV- -KDqveNHHLSDDRLFLYYLQNGKDMYTDDEL- -D- -IDNLSQYDIDHI 846

WP ^"001040096 77 6 RQRLTTLRESLA NLKS EKKPKYV- -KDqveNHHLSDDRLFLYYLQNGKDMYTDDEL- -D- -IDNLSQYDIDHI 846

WP ^"001040097 77 6 RQRLTTLRESLA NLKS EKKPKYV- -KDqveNHHLSDDRLFLYYLQNGKDMYTDDEL- -D- -IDNLSQYDIDHI 846

WP ^"001040098 77 6 RQRLTTLRESLA NLKS EKKPKYV- -KDqveNHHLSDDRLFLYYLQNGKDMYTDDEL- -D- -IDNLSQYDIDHI 846

WP ^"001040099 77 6 RQRLTTLRESLA NLKS EKKPKYV- -KDqveNHHLSDDRLFLYYLQNGKDMYTDDEL- -D- -IDNLSQYDIDHI 846

WP ^"001040100 77 6 RQRLTTLRESLA NLKS EKKPKYV- -KDqveNHHLSDDRLFLYYLQNGKDMYTDDEL- -D- -IDNLSQYDIDHI 846

WP ^"001040104 77 9 RQRYKLLDDGVK NLAS NILKEYP- -TD- —NQALQNERLFLYYLQNGRDMYTGEAL- -D- -IDNLSQYDIDHI 846

WP ^"001040105 77 9 RQRYKLLDDGVK NLAS NILKEYP- -TD- —NQALQNERLFLYYLQNGRDMYTGEAL- -D- -IDNLSQYDIDHI 846

WP ^"001040106 77 9 RQRYKLLEEGVK NLAS NILKEYP- -TD- —NQALQNERLFLYYLQNGRDMYTGEAL- -D- -IDNLSQYDIDHI 846

WP ^"001040107 77 9 RQRYKLLEEGVK NLAS NILKEYP- -TD- —NQALQNERLFLYYLQNGRDMYTGEAL- -D- -IDNLSQYDIDHI 846

WP ^"001040108 77 9 RQRYKLLEEGVK NLAS NILKEYP- -TD- —NQALQNERLFLYYLQNGRDMYTGETL- -D- -IDNLSQYDIDHI 846

WP ^"001040109 77 9 RQRYKLLEEGVK NLAS NILKEYP- -TD- —NQALQNERLFLYYLQNGRDMYTGEAL- -D- -IDNLSQYDIDHI 846

WP ^"001040110 77 9 RQRYKLLEEGVK NLAS NILKEYP- -TD- —NQALQNERLFLYYLQNGRDMYTGEAL- -D- -IDNLSQYDIDHI 846

WP ^"015058523 77 9 RQRYKLLEDGVK NLAS DILKEYP- -TD- —NQALQNERLFLYYLQNGRDMYTGEAL- -D- -IDNLSQYDIDHI 846

WP ^"017643650 77 6 RQRLTTLRESLA NLKS EKKPKYV- -KDqveNHHLSDDRLFLYYLQNGKDMYTDDEL- -D- -IDNLSQYDIDLI 846

WP ^"017647151 77 9 RQRYKLLDDGVK NLAS NILKEYP- -TD- —NQALQNERLFLYYLQNGRDMYTGKAL- -D- -IDNLSQYDIDHI 846

WP ^"017648376 77 9 RQRYKLLDDGVK NLAS NILKEYP- -TD- —NQALQNERLFLYYLQNGRDMYTGKAL- -D- -IDNLSQYDIDHI 846

WP ^"017649527 77 9 RQRYKLLDDGVK NLAS NILKEYP- -TD- —NQALQNERLFLYYLQNGRDMYTGEAL- -D- -IDNLSQYDIDHI 846

WP ^"017771611 77 9 RQRYKLLEEGVK NLAS NILKEYP- -TD- —NQALQNERLFLYYLQNGRDMYTGEAL- -D- -IDNLSQYDIDHI 846

WP ^"017771984 77 9 RQRYKLLDDGVK NLAS NILKEYP- -TD- —NQALQNERLFLYYLQNGRDMYTGEAL- -D- -IDNLSQYDIDHI 846

CFQ25032 77 9 RQRYKLLDDGVK NLAS NILKEYP- -TD- —NQALQNERLFLYYLQNGRDMYTGEAL- -D- -IDNLSQYDIDHI 846

CFV16040 77 9 RQRYKLLDDGVK NLAS NILKEYP- -TD- —NQALQNERLFLYYLQNGRDMYTGEAL- -D- -IDNLSQYDIDHI 846

KLJ37842 77 9 RQRYKLLDDGVK NLAS NILKEYP- -TD- —NQALQNERLFLYYLQNGRDMYTGEAL- -D- -IDNLSQYDIDHI 846

KLJ72361 77 9 RQRYKLLDDGVK NLAS NILKEYP- -TD- —NQALQNERLFLYYLQNGRDMYTGEAL- -D- -IDNLSQYDIDHI 846

KLL20707 79 3 RQRYKLLDDGVK NLAS NILKEYP- -TD- —NQALQNERLFLYYLQNGRDMYTGEAL- -D- -IDNLSQYDIDHI 860

KLL42645 77 9 RQRYKLLEEGVK NLAS NILKEYP- -TD- —NQALQNERLFLYYLQNGRDMYTGEAL- -D- -IDNLSQYDIDHI 846

WP 047207273 77 9 RQRYKLLDDGVK NLAS NILKEYP- -TD- —NQALQNERLFLYYLQNGRDMYTGEAL- -D- -IDNLSQYDIDHI 846

WP ^"047209694 77 6 RQRLTTLRESLA NLKS EKKPKYV- -KDqveNHHLSDDRLFLYYLQNGKDMYTDDEL- -D- -IDNLSQYDIDHI 846

WP 050198062 77 9 RQRYKLLDDGVK NLAS NILKEYP- -TD- —NQALQNERLFLYYLQNGRDMYTGEAL- -D- -IDNLSQYDIDHI 846

WP ^"050201642 77 9 RQRYKLLDDGVK NLAS NILKEYP- -TD- —NQALQNERLFLYYLQNGRDMYTGEAL- -D- -IDNLSQYDIDHI 846

WP ^"050204027 77 9 RQRYKLLEEGVK NLAS NILKEYP- -TD- —NQALQNERLFLYYLQNGRDMYTGEAL- -D- -IDNLSQYDIDHI 846

WP ^"050881965 77 9 RQRYKLLDDGVK NLAS NILKEYP- -TD- —NQALQNERLFLYYLQNGRDMYTGEAL- -D- -IDNLSQYDIDHI 846

WP 050886065 779 RQRYKLLDDGVK NLAS NILKEYP--TD- -NQALQNERLFLYYLQNGRDMYTGEAL--D--IDNLSQYDIDHI 846

AHN30376 779 RQRYKLLEDGVK NLAS DILKEYP- -TD- -NQALQNERLFLYYLQNGRDMYTGEAL- -D- -IDSLSQYDIDHI 846

EA078426 779 RQRYKLLDDGVK NLAS NILKEYP- -TD- -NQALQNERLFLYYLQNGRDMYTGEAL- -D- -IDNLSQYDIDHI 846

CCW42055 779 RQRYKLLDDGVR NLAS NILKEYP- -TD- -NQALQNERLFLYYLQNGRDMYTEKAL- -D- -IDNLSQYDIDHI 846

WP 003041502 778 QQRLKLLQDSLK PVNI K N- -VE- -NQQLQNDRLFLYYIQNGKDMYTGETL- -D- -INNLSQYDIDHI 840

WP 037593752 779 QQRLKLLQDSLK PVNI K N- -VE- -NQQLQNDRLFLYYIQNGKDMYTGETL- -D- -INNLSQYDIDHI 841

WP 049516684 779 QQRLKLLQDSLK PVNI K N- -VE- -NQQLQNDRLFLYYIQNGKDMYTGETL- -D- -INNLSQYDIDHI 841

GAD46167 778 QQRLKLLQDSLK PVNI K N- -VE- -NQQLQNDRLFLYYIQNGKDMYTGETL- -D- -INNLSQYDIDHI 840

WP 018363470 779 QQRLKKLQNSLK PSYI E DK- -VE- -NSHLQNDQLFLYYIQNGKDMYTGDEL- -D- -IDHLSDYDIDHI 849

WP 003043819 787 RERKKRIEEGIK ELES QILKENP- -VE- -NTQLQNEKLYLYYLQNGRDMYVDQEL- -D- -INRLSDYDVDHI 850

WP 006269658 778 QQRLKLLQDSLK PVNI K N- -VE- -NQQLQNDRLFLYYIQNGKDMYTGETL- -D- -INNLSQYDIDHI 840

WP 048800889 778 QQRLKLLQDSLT PVSI K N- -VE- -NQQLQNDRLFLYYIQNGKDMYTGEEL- -D- -IHHLSDYDIDHI 840

WP 012767106 777 RERMKRIEEGIK ELGS QILKEHP- -VE- -NTQLQNEKLYLYYLQNGRDMYVDQEL- -D- -INRLSDYDVDHI 840

WP 014612333 777 RERMKRIEEGIK ELGS QILKEHP- -VE- -NTQLQNEKLYLYYLQNGRDMYVDQEL- -D- -INRLSDYDVDHI 840

WP 015017095 777 RERMKRIEEGIK ELGS QILKEHP- -VE- -NTQLQNEKLYLYYLQNGRDMYVDQEL- -D- -INRLSDYDVDHI 840

WP 015057649 777 RERMKRIEEGIK ELGS QILKEHP- -VE- -NTQLQNEKLYLYYLQNGRDMYVDQEL- -D- -INRLSDYDVDHI 840

WP 048327215 777 RERMKRIEEGIK ELGS QILKEHP- -VE- -NTQLQNEKLYLYYLQNGRDMYVDQEL- -D- -INRLSDYDVDHI 840

WP 049519324 777 RERMKRIEEGIK ELGS QILKEHP- -VE- -NTQLQNEKLYLYYLQNGRDMYVDQEL- -D- -INRLSDYDVDHI 840

WP 012515931 777 RQRMRKLEETAK KLGS NILKEHP- -VD- -NSQLQNDKRYLYYLQNGKDMYTGDDL- -D- -IDYLSSYDIDHI 840

WP 021320964 777 RQRMRKLEETAK KLGS NILKEHP- -VD- -NSQLQNDKRYLYYLQNGKDMYTGDDL- -D- -IDYLSSYDIDHI 840

WP 037581760 777 RQRMRKLEETAK KLGS NILKEHP- -VD- -NSQLQNDKRYLYYLQNGKDMYTGDDL- -D- -IDYLSSYDIDHI 840

WP 004232481 778 NQRLKRLQDSLK PSYV D SK- -VE- -NSHLQNDRLFLYYIQNGKDMYTGEEL- -D- -IDHLSDYDIDHI 848

WP 009854540 779 QQRLKKLQSSLK PSYI E DK- -VE- -NSHLQNDQLFLYYIQNGKDMYTGDEL- -D- -IDHLSDYDIDHI 849

WP 012962174 779 QQRLKKLQDSLK PSYI E GK- -VE- -NNHLQDDRLFLYYIQNGKDMYTGDEL- -D- -IDHLSDYDIDHI 849

WP 039695303 781 QQRLKKLQNSLK PSYI E DK- -VE- -NSHLQNDQLFLYYIQNGKDMYTGDEL- -D- -IDHLSDYDIDHI 851

WP 014334983 778 NQRLKRLQDSLK PSYV D SK- -VE- -NSHLQNDRLFLYYIQNGKDMYTGEEL- -D- -IDRLSDYDIDHI 848

WP 003099269 778 RQRLRKLEEVHK NTGS KILKEYN- -VS- -NTQLQSDRLYLYLLQDGKDMYTGKEL- -D- -YDNLSQYDIDHI 841

AHY15608 778 RQRLRKLEEVHK NTGS KILKEYN- -VS- -NTQLQSDRLYLYLLQDGKDMYTGKEL- -D- -YDNLSQYDIDHI 841

AHY17476 778 RQRLRKLEEVHK NTGS KILKEYN- -VS- -NTQLQSDRLYLYLLQDGKDMYTGKEL- -D- -YDNLSQYDIDHI 841

ESR09100

AGM98575 778 RQRLRKLEEVHK NTGS KILKEYN- -VS- -NTQLQSDRLYLYLLQDGKDMYTGKEL- -D- -YDNLSQYDIDHI 841

ALF27331 778 QQRLKGLTDSIK EFGS QILKEHP- -VE- -NSQLQNDRLFLYYLQNGRDMYTGEEL- -D- -IDYLSQYDIDHI 841

WP 018372492 791 AQRLKKIEDGIK -LGS DLLKQNP- -IQd- -NKDLQKEKLFLYYMQNGIDLYTGQPLncD- -PDSLAFYDVDHI 857

WP 045618028 777 QQRYKRIEDALK NLAH NILKEHP- -TD- -NIQLQNDRLFLYYLQNGKDMYTGKSL- -D- -INQLSSCDIDHI 844

WP 045635197 776 QQRYKRIEDSLK ILAS NILKENP- -TD- -NNQLQNDRLFLYYLQNGKDMYTGEAL- -D- -INQLSSYDIDHI 843

WP 002263549 778 QQRLKGLTDSIK EFGS QILKEHP- -VE- -NSQLQNDRLFLYYLQNGRDMYTGEEL- -D- -IDYLSQYDIDHI 841

WP 002263887 778 QQRLKGLTDSIK EFGS QILKEHP- -VE- -NSQLQNDRLFLYYLQNGRDMYTGEEL- -D- -IDYLSQYDIDHI 841

WP 002264920 778 QQRLKGLTDSIK EFGS QILKEHP- -VE- -NSQLQNDRLFLYYLQNGRDMYTGEEL- -D- -IDYLSQYDIDHI 841

WP 002269043 778 QQRLKGLTDSIK EFGS QILKEHP- -VE- -NSQLQNDRLFLYYLQNGRDMYTGEEL- -D- -IDYLSQYDIDHI 841

WP 002269448 778 QQRLKGLTDSIK EFGS QILKEHP--VE --NSQLQNDRLFLYYLQNGRDMYTGEEL--D--IDYLSQYDIDHI 841

WP ^"002271977 778 QQRLKGLTDSIK EFGS QILKEHP- -VE - -NSQLQNDRLFLYYLQNGRDMYTGEEL- -D- -IDYLSQYDIDHI 841

WP ^"002272766 778 QQRLKGLTDSIK EFGS QILKEHP- -VE - -NSQLQNDRLFLYYLQNGRDMYTGEEL- -D- -IDYLSQYDIDHI 841

WP ^"002273241 778 QQRLKGLTDSIK EFGS QILKEHP- -VE - -NSQLQNDRLFLYYLQNGRDMYTGEEL- -D- -IDYLSQYDIDHI 841

WP ^"002275430 778 QQRLKGLTDSIK EFGS QILKEHP- -VE - -NSQLQNDRLFLYYLQNGRDMYTGEEL- -D- -IDYLSQYDIDHI 841

WP ^"002276448 778 QQRLKGLTDSIK EFGS QILKEHP- -VE - -NSQLQNDRLFLYYLQNGRDMYTGEEL- -D- -IDYLSQYDIDHI 841

WP ^"002277050 779 QQRYKRLKEAIK DLNH KILKEHP- -TD - -NQALQNNRLFLYYLQNGRDMYTGESL- -D- -INRLSDYDIDHV 846

WP ^"002277364 778 QQRLKGLTDSIK EFGS QILKEHP- -VE - -HSQLQNDRLFLYYLQNGRDMYTGEEL- -D- -IDYLSQYDIDHI 841

WP ^"002279025 778 QQRLKGLTDSIK EFGS QILKEHP- -VE - -NSQLQNDRLFLYYLQNGRDMYTGEEL- -D- -IDYLSQYDIDHI 841

WP ^"002279859 778 QQRLKGLTDSIK EFGS QILKEHP- -VE - -NSQLQNDRLFLYYLQNGRDMYTGEEL- -D- -IDYLSQYDIDHI 841

WP ^"002280230 778 QQRLKGLTDSIK EFGS QILKEHP- -VE - -NSQLQNDRLFLYYLQNGRDMYTGEEL- -D- -IDYLSQYDIDHI 841

WP ^"002281696 778 QQRLKGLTDSIK EFGS QILKEHP- -VE - -NSQLQNDRLFLYYLQNGRDMYTGEEL- -D- -IDYLSQYDIDHI 841

WP ^"002282247 779 QQRYKRLKEAIK DLNH KILKEHP- -TD - -NQALQNNRLFLYYLQNGRDMYTGESL- -D- -INRLSDYDIDHV 846

WP ^"002282906 778 QQRLKGLTDSIK EFGS QILKEHP- -VE - -NSQLQNDRLFLYYLQNGRDMYTGEEL- -D- -IDYLSQYDIDHI 841

WP ^"002283846 778 QQRLKGLTDSIK EFGS QILKEHP- -VE - -NSQLQNDRLFLYYLQNGRDMYTGEEL- -D- -IDYLSQYDIDHI 841

WP ^"002287255 778 QQRLKGLTDSIK EFGS QILKEHP- -VE - -HSQLQNDRLFLYYLQNGRDMYTGEEL- -D- -IDYLSQYDIDHI 841

WP ^"002288990 778 QQRLKGLTDSIK EFGS QILKEHP- -VE - -NSQLQNDRLFLYYLQNGRDMYTGEEL- -D- -IDYLSQYDIDHI 841

WP ^"002289641 778 QQRLKGLTDSIK EFGS QILKEHP- -VE - -NSQLQNDRLFLYYLQNGRDMYTGEEL- -D- -IDYLSQYDIDHI 841

WP ^"002290427 778 QQRLKGLTDSIK EFGS QILKEHP- -VE - -NSQLQNDRLFLYYLQNGRDMYTGEEL- -D- -IDYLSQYDIDHI 841

WP ^"002295753 778 QQRLKGLTDSIK EFGS QILKEHP- -VE - -NSQLQNDRLFLYYLQNGRDMYTGEEL- -D- -IDYLSQYDIDHI 841

WP ^"002296423 778 QQRLKGLTDSIK EFGS QILKEHP- -VE - -NSQLQNDRLFLYYLQNGRDMYTGEEL- -D- -IDYLSQYDIDHI 841

WP ^"002304487 788 QKRYKRLEEAIK DLNH KILKEHP- -TD - -NQALQNDRLFLYYLQNGRDMYTEDPL- -D- -INRLSDYDIDHI 855

WP ^"002305844 778 QQRLKGLTDSIK EFGS QILKEHP- -VE - -NSQLQNDRLFLYYLQNGRDMYTGEEL- -D- -IDYLSQYDIDHI 841

WP ^"002307203 778 QQRLKGLTDSIK EFGS QILKEHP- -VE - -NSQLQNDRLFLYYLQNGRDMYTGEEL- -D- -IDYLSQYDIDHI 841

WP ^"002310390 778 QQRLKGLTDSIK EFGS QILKEHP- -VE - -NSQLQNDRLFLYYLQNGRDMYTGEEL- -D- -IDYLSQYDIDHI 841

WP ^"002352408 778 QQRLKGLTDSIK EFGS QILKEHP- -VE - -NSQLQNDRLFLYYLQNGRDMYTGEEL- -D- -IDYLSQYDIDHI 841

WP ^"012997688 778 QQRLKGLTDSIK EFGS QILKEHP- -VK - -HSQLQNDRLFLYYLQNGRDMYTGEEL- -D- -IDYLSQYDIDHI 841

WP ^"014677909 778 QQRLKGLTDSIK EFGS QILKEHP- -VE - -NSQLQNDRLFLYYLQNGRDMYTGEEL- -D- -IDYLSQYDIDHI 841

WP ^"019312892 778 QQRLKGLTDSIK EFGS QILKEHP- -VE - -NSQLQNDRLFLYYLQNGRDMYTGEEL- -D- -IDYLSQYDIDHI 841

WP ^"019313659 778 QQRLKGLTDSIK EFGS QILKEHP- -VE - -NSQLQNDRLFLYYLQNGRDMYTGEEL- -D- -IDYLSQYDIDHI 841

WP ^"019314093 778 QQRLKGLTDSIK EFGS QILKEHP- -VE - -NSQLQNDRLFLYYLQNGRDMYTGEEL- -D- -IDYLSQYDIDHI 841

WP ^"019315370 778 QQRLKGLTDSIK EFGS QILKEHP- -VE - -NSQLQNDRLFLYYLQNGRDMYTGEEL- -D- -IDYLSQYDIDHI 841

WP ^"019803776 778 QQRLKGLTDSIK EFGS QILKEHP- -VE - -NSQLQNDRLFLYYLQNGRDMYTGEEL- -D- -IDYLSQYDIDHI 841

WP ^"019805234 778 QQRLKGLTDSIK EFGS QILKEHP- -VE - -NSQLQNDRLFLYYLQNGRDMYTGEEL- -D- -IDYLSQYDIDHI 841

WP ^"024783594 778 QQRLKGLTDSIK EFGS QILKEHP- -VE - -NSQLQNDRLFLYYLQNGRDMYTGEEL- -D- -IDYLSQYDIDHI 841

WP ^"024784288 779 QQRYKRLKEAIK DLNH KILKEHP- -TD - -NQALQNNRLFLYYLQNGRDMYTGESL- -D- -INRLSDYDIDHV 846

WP ^"024784666 778 QQRLKGLTDSIK EFGS QILKEHP- -VE - -HSQLQNDRLFLYYLQNGRDMYTGEEL- -D- -IDYLSQYDIDHI 841

WP 024784894 778 QQRLKGLTDSIK EFGS QILKEHP- -VE - -NSQLQNDRLFLYYLQNGRDMYTGEEL- -D- -IDYLSQYDIDHI 841

WP 024786433 779 QQRYKRLKEAIK DLNH KILKEHP- -TD - -NQALQNNRLFLYYLQNGRDMYTGESL- -D- -INRLSDYDIDHV 846

WP 049473442 778 QQRLKGLTDSIK EFGS QILKEHP--VE- -NSQLQNDRLFLYYLQNGRDMYTGEEL--D--IDYLSQYDIDHI 841

WP 049474547 778 QQRLKGLTDSIK EFGS QILKEHP- -VE- -NSQLQNDRLFLYYLQNGRDMYTGEEL- -D- -IDYLSQYDIDHI 841

EMC03581 771 QQRLKGLTDSIK EFGS QILKEHP- -VE- -HSQLQNDRLFLYYLQNGRDMYTGEEL- -D- -IDYLSQYDIDHI 834

WP 000428612 779 QQRYKRIEDSLK ILAS KILKEHP- -TD- -NIQLQNDRLFLYYLQNGRDMYTGKPL- -D- -INQLSSYDIDHI 846

WP 000428613 777 QQRYKRIEDALK NLAS NILKEHP- -TN- -NIQLQNDRLFLYYLQNGRDMYTGKPL- -D- -INQLSSYDIDHI 844

WP 049523028 776 QQRLKTLSDAIS ELG- NILKEHP- -TD- -NIQLQNDRLFLYYLQNGKDMYTGEAL- -D- -INQLSNYDIDHI 839

WP 003107102 747 RERLRKLEEVHK NIGS KILKEHE- -IS- -NAQLQSDRVYLYLLQDGKDMYTGKDL- -D- -FDRLSQYDIDHI 810

WP 054279288 779 RERMKRVQEVLK KLGS QLLKEHP- -VE- -NFQLQNERLYLYYLQNGKDMYTGEEL- -S- -ISNLSHYDIDHI 842

WP 049531101 777 QQRYKRIEDSLK ILAS NILKEHP- -TD- -NIQLQNDRLFLYYLQNGKDMYTGNPL- -D- -INHLSSYDIDHI 844

WP 049538452 777 QQRYKRIENSLK ILAS KILKEHP- -TD- -NNQLQNDRLFLYYLQNGKDMYTGEAL- -D- -INQLSSCDIDHI 844

WP 049549711 777 QQRYKRIEDSLK ILAS NILKENP- -TD- -NNQLQNDRLFLYYLQNGKDMYTGEAL- -D- -INQLSSYDIDHI 844

WP 007896501 781 RQRLKKIKEVHK KTGS RILEDNSerlT- -NLTLQDNRLYLYLLQDGKDMYTGQDL- -D- -INNLSQYDIDHI 846

EFR44625 733 RQRLKKIKEVHK KTGS RILEDNSerlT- -NLTLQDNRLYLYLLQDGKDMYTGQDL- -D- -INNLSQYDIDHI 798

WP 002897477 776 QQRYKRIEDALK NLAP NILKENP- -TD- -NIQLKNDRLFLYYLQNGKDMYTGKPL- -D- -INQLSSYDIDHI 843

WP 002906454 776 QQRYKRIEDALK NLAP NILKENP- -TD- -NIQLQNDRLFLYYLQNGKDMYTGKAI- -D- -INQLSNYDIDHI 843

WP 009729476 777 QQRYKRIEDSLK ILAS KILKEHP- -TD- -NIQLQNDRLFLYYLQNGKDMYTGEAL- -D- -INQLSSCDIDHI 844

CQR24647 780 QQRLGSLTKAIQ DFGS DILKRYP- -VE- -NNQLQNDQLYLYYLQNGKDMYTGDTL- -D- -IHNLSQYDIDHI 843

WP 000066813 779 QQRYKRIEDSLK NLAS NILKENP- -TD- -NIQLQNDRLFLYYLQNGRDMYTGKPL- -E- -INQLSNYDIDHI 846

WP 009754323 777 QQRYKRIEDALK NLAP TISKENP- -TD- -NIQLQNDRLFLYYLQNGKDMYTGEAL- -D- -INQLSSYDIDHI 844

WP 044674937 776 QQRYKKIENAIK NLNS KILKEYP- -TN- -NQALQNDRLFLYYLQNGKDMYTDEEL- -D- -IDQLSQYDIDHI 843

WP 044676715 778 QQRYKKIENAIK NLNS KILKEYP- -TN- -NQALQNDRLFLYYLQNGKDMYTDEEL- -D- -IDQLSQYDIDHI 845

WP 044680361 778 QQRYKKIENAIK NLNS KILKEYP- -TN- -NQALQNDRLFLYYLQNGKDMYTDEEL- -D- -IDQLSQYDIDHI 845

WP 044681799 776 QQRYKKIENAIK NLNS KILKEYP- -TN- -NQALQNDRLFLYYLQNGKDMYTDEEL- -D- -IDQLSQYDIDHI 843

WP 049533112 778 QQRLKLLQDSLK PVNI K N- -VE- -NQQLQNDRLFLYYIQNGKDMYTGETL- -D- -INNLSQYDIDHI 840

WP 029090905 753 TPRDKFIEKAYA ETDT EHLKELK- —Qr -SKQLSSQRLFLYFIQNGKCMYSGEHL- -D- -IERLDSYEVDHI 823

WP 006506696 777 ESKIKKLENVYK DEQT SVLEELKg -FDn -TKKISSDSLFLYFTQLGKCMYSGKKL- -D- -IDSLDKYQIDHI 849

AIT42264 778 RERMKRIEEGIK ELGS QILKEHP- -VE- -NTQLQNEKLYLYYLQNGRDMYVDQEL- -D- -INRLSDYDVDHI 841

WP 034440723 785 KARLKKIQEGLE NLDS HVEKQAL- —D- -EEMLKSPKYYLYCLQNGKDIYTGKDL- -D- -IGQLQTYDIDHI 848

AKQ21048 778 RERMKRIEEGIK ELGS QILKEHP- -VE- -NTQLQNEKLYLYYLQNGRDMYVDQEL- -D- -INRLSDYDVDHI 841

WP 004636532 781 KERLEKLTEAIK EFDG —VKVKD- -LK- -NENLRNDRLYLYYLQNGRDMYTNEPL- -D- -INNLSKYDIDHI 845

WP 002364836 789 IQRLKIVEKAMA EIGS NLLKEQP- -TT- -NEQLRDTRLFLYYMQNGKDMYTGDEL- -S- -LHRLSHYDIDHI 852

WP 016631044 740 IQRLKIVEKAMA EIGS NLLKEQP- -TT- -NEQLRDTRLFLYYMQNGKDMYTGDEL- -S- -LHRLSHYDIDHI 803

EMS75795 525 KPRLKALEEALK SFDS PLLKEQP- -VD- -NQALQKDRLYLYYLQNGKDMYTGEAL- -D- -IDRLSEYDIDHI 588

WP 002373311 789 IQRLKIVEKAMA EIGS NLLKEQP- -TT- -NEQLRDTRLFLYYMQNGKDMYTGDEL- -S- -LHRLSHYDIDHI 852

WP 002378009 789 IQRLKIVEKAMA EIGS NLLKEQP- -TT- -NEQLRDTRLFLYYMQNGKDMYTGDEL- -S- -LHRLSHYDIDHI 852

WP 002407324 789 IQRLKIVEKAMA EIGS NLLKEQP- -TT- -NEQLRDTRLFLYYMQNGKDMYTGDEL- -s- -LHRLSHYDIDHI 852

WP 002413717 789 IQRLKIVEKAMA EIGS NLLKEQP- -TT- -NEQLRDTRLFLYYMQNGKDMYTGDEL- -s- -LHRLSHYDIDHI 852

WP 010775580 791 IQRLKIVEKAMA EIGS NLLKEQP- -TT- -NEQLRDTRLFLYYMQNGKDMYTGDEL- -s- -LHRLSHYDIDHI 854

WP 010818269 789 IQRLKIVEKAMA EIGS NLLKEQP- -TT- -NEQLRDTRLFLYYMQNGKDMYTGDEL- -s- -LHRLSHYDIDHI 852

WP 010824395 789 IQRLKIVEKAMA EIGS NLLKEQP--TT- -NEQLRDTRLFLYYMQNGKDMYTGDEL--S--LHRLSHYDIDHI 852

WP 016622645 789 IQRLKIVEKAMA EIGS NLLKEQP- -TT- -NEQLRDTRLFLYYMQNGKDMYTGDEL- -S- -LHRLSHYDIDHI 852

WP 033624816 789 IQRLKIVEKAMA EIGS NLLKEQP- -TT- -NEQLRDTRLFLYYMQNGKDMYTGDEL- -s- -LHRLSHYDIDHI 852

WP 033625576 789 IQRLKIVEKAMA EIGS NLLKEQP- -TT- -NEQLRDTRLFLYYMQNGKDMYTGDEL- -s- -LHRLSHYDIDHI 852

WP 033789179 789 IQRLKIVEKAMA EIGS NLLKEQP- -TT- -NEQLRDTRLFLYYMQNGKDMYTGDEL- -s- -LHRLSHYDIDHI 852

WP 002310644 789 RPRLKALEESLK DFGS QLLKEYP- -TD- -NSSLQKDRLYLYYLQNGRDMYTGAPL- -D- -IHRLSDYDIDHI 852

WP 002312694 790 RPRLKALEESLK DFGS QLLKEYP- -TD- -NSSLQKDRLYLYYLQNGRDMYTGAPL- -D- -IHRLSDYDIDHI 853

WP 002314015 790 RPRLKALEESLK DFGS QLLKEYP- -TD- -NSSLQKDRLYLYYLQNGRDMYTGAPL- -D- -IHRLSDYDIDHI 853

WP 002320716 790 RPRLKALEESLK DFGS QLLKEYP- -TD- -NSSLQKDRLYLYYLQNGRDMYTGAPL- -D- -IHRLSDYDIDHI 853

WP 002330729 789 RPRLKALEESLK DFGS QLLKEYP- -TD- -NSSLQKDRLYLYYLQNGRDMYTGAPL- -D- -IHRLSDYDIDHI 852

WP 002335161 790 RPRLKALEESLK DFGS QLLKEYP- -TD- -NSSLQKDRLYLYYLQNGRDMYTGAPL- -D- -IHRLSDYDIDHI 853

WP 002345439 790 RPRLKALEESLK DFGS QLLKEYP- -TD- -NSSLQKDRLYLYYLQNGRDMYTGAPL- -D- -IHRLSDYDIDHI 853

WP 034867970 781 SPRLKALENGLK QIGS TLLKEQP- -TD- -NKALQKERLYLYYLQNGRDMYTGEPL- -E- -IENLHQYEVDHI 844

WP 047937432 790 RPRLKALEESLK DFGS QLLKEYP- -TD- -NSSLQKDRLYLYYLQNGRDMYTGAPL- -D- -IHRLSDYDIDHI 853

WP 010720994 781 KPRLKALENGLK QIGS TLLKEQP- -TD- -NKALQKERLYLYYLQNGRDMYTGEPL- -E- -IENLHQYEVDHI 844

WP 010737004 781 SPRLKALENGLK QIGS TLLKEQP- -TD- -NKALQKERLYLYYLQNGRDMYTGEPL- -E- -IENLHQYEVDHI 844

WP 034700478 781 KPRLKALENGLK QIGS TLLKEQP- -TD- -NKALQKERLYLYYLQNGRDMYTGEPL- -E- -IENLHQYEVDHI 844

WP 007209003 782 KPRLKGIENGLK EFSD SVLKGSS- -ID- -NKQLQNDRLYLYYLQNGKDMYTGHEL- -D- -IDHLSTYDIDHI 845

WP 023519017 775 RPRLKALEEALK NIDS PLLKDYP- -TD- -NQALQKDRLYLYYLQNGKDMYTGEPL- -E- -IHRLSEYDIDHI 838

WP 010770040 782 NPRMKALEEAMR NLRS NLLKEYP- -TD- -NQALQNDRLYLYYLQNGKDMYTGLDL- -S- -LHNLSSYDIDHI 845

WP 048604708 779 RPRLKNLEKAID DLDS EILKKHP- -VD- -NKALQKDRLYLYYLQNGKDMYTNEEL- -D- -IHKLSTYDIDHI 842

WP 010750235 784 KPRLKSLEEALK NFDS QLLKERP- -VD- -NQSLQKDRLYLYYLQNGKDMYTGESL- -D- -IDRLSEYDIDHI 847

AII16583 817 RERMKRIEEGIK ELGS QILKEHP- -VE- -NTQLQNEKLYLYYLQNGRDMYVDQEL- -D- -INRLSDYDVDHI 880

WP 029073316 789 DSFVNQMLKLYK DFED EANKHLKg -EDa -KSKIRSERLKLYYTQMGKCMYTGKSL- -D- -IDRLDTYQVDHI 860

WP 031589969 789 DSFVNQMLKLYK DFED EANKHLKg -EDa -KSKIRSERLKLYYTQMGKCMYTGKSL- -D- -IDRLDTYQVDHI 860

KDA45870 772 EDRVQQIVKNLK ELPK P- —S- -NAELSDERKYLYCLQNGRDMYTGAPL- -D- -YDHLQFYDVDHI 833

WP 039099354 789 KRQVEQVYQNI S EL— EIRNELK- --D1 sNSALSNTRLFLYFMQGGRDMYTGDSL- -N- -IDRLSTYDIDHI 856

AKP02966 786 RLQSKLLNKANG -LVP EELKKHKn —D- LSSERIMLYFLQNGKSLYSEESL- -N- -INKLSDYQVDHI 858

WP 010991369 781 RPRYKSLEKAIK EFGS QILKEHP- -TD- -NQELRNNRLYLYYLQNGKDMYTGQDL- -D- -IHNLSNYDIDHI 844

WP 033838504 781 RPRYKSLEKAIK EFGS QILKEHP- -TD- -NQELRNNRLYLYYLQNGKDMYTGQDL- -D- -IHNLSNYDIDHI 844

EHN60060 784 RPRYKSLEKAIK EFGS QILKEHP- -TD- -NQELRNNRLYLYYLQNGKDMYTGQDL- -D- -IHNLSNYDIDHI 847

EFR89594 550 RPRYKSLEKAIK EFGS QILKEHP- -TD- -NQELKNNRLYLYYLQNGKDMYTGQDL- -D- -IHNLSNYDIDHI 613

WP 038409211 781 KPRFISLEKAIK EFGS QILKEHP- -TD- -NQCLKNDRLYLYYLQNGKDMYTGKEL- -D- -IHNLSNYDIDHI 844

EFR95520 400 KPRFISLEKAIK EFGS QILKEHP- -TD- -NQCLKNDRLYLYYLQNGKDMYTGKEL- -D- -IHNLSNYDIDHI 463

WP 003723650 781 KPRYKSLEKAIK EFGS QILKEHP- -TD- -NQELKNNRLYLYYLQNGKDMYTGQEL- -D- -IHNLSNYDIDHI 844

WP 003727705 781 KPRYKSLEKAIK DFGS QILKEHP- -TD- -NQELKNNRLYLYYLQNGKDIYTGQEL- -D- -IHNLSNYDIDHI 844

WP 003730785 781 KPRYKSLEKAIK DFGS QILKEHP- -TD- -NQELKNNRLYLYYLQNGKDIYTGQEL- -D- -IHNLSNYDIDHI 844

WP 003733029 781 KPRYKSLEKAIK EFGS QILKEHP- -TD- -NQELKNNRLYLYYLQNGKDMYTGQEL- -D- -IHNLSNYDIDHI 844

WP 003739838 781 RPRYKSLEKAIK EFGS QILKEHP- -TD- -NQELRNNRLYLYYLQNGKDMYTGQEL- -D- -IHNLSNYDIDHI 844

WP 014601172 781 KPRYKSLEKAIK EFGS KILKEHP--TD- -NQELKNNRLYLYYLQNGKDMYTGQEL--D--IHNLSNYDIDHI 844

WP 023548323 7 81 KPRYKSLEKAIK EFGS QILKEHP- -TD- -NQELKNNRLYLYYLQNGKDMYTGQEL- -D- -IHNLSNYDIDHI 844

WP 031665337 7 81 KPRYKSLEKAIK EFGS QILKEHP- -TD- -NQELKNNRLYLYYLQNGKDMYTGQEL- -D- -IHNLSNYDIDHI 844

WP 031669209 7 81 KPRYKSLEKAIK EFGS QILKEHP- -TD- -NQELKNNRLYLYYLQNGKDMYTGQEL- -D- -IHNLSNYDIDHI 844

WP 033920898 7 81 KPRYKSLEKAIK EFGS QILKEHP- -TD- -NQELKNNRLYLYYLQNGKDMYTGQEL- -D- -IHNLSNYDIDHI 844

AKI42028 7 84 KPRYKSLEKAIK EFGS KILKEHP- -TD- -NQELKNNRLYLYYLQNGKDMYTGQEL- -D- -IHNLSNYDIDHI 847

AKI50529 7 84 KPRYKSLEKAIK EFGS QILKEHP- -TD- -NQELKNNRLYLYYLQNGKDMYTGQEL- -D- -IHNLSNYDIDHI 847

EFR83390 2 29 RPRYKSLEKAIK EFGS QILKEHP- -TD- -NQELKNNRLYLYYLQNGKDIYTGQEL- -D- -IHNLSNYDIDHI 292

WP 046323366 7 81 KPRFTSLEKAIK ELGS QILKEHP- -TD- -NQGLKNDRLYLYYLQNGKDMYTGQEL- -D- -IHNLSNYDIDHV 844

AKE81011 7 94 RERMKRIEEGIK ELGS QILKEHP- -VE- -NTQLQNEKLYLYYLQNGRDMYVDQEL- -D- -INRLSDYDVDHI 857

CU082355 7 81 ESKIKKLENVYK DEQT SVLEELKg -FDn -TKKISSDSLFLYFTQLGKCMYSGKKL- -D- -IDSLDKYQIDHI 853

WP 033162887 7 84 ESKIAKLQKIYE NLQT QVYESLKk -EDa -KKRMETDALYLYYLQMGKSMYSGKPL- -D- -IDKLSTYQIDHI 855

AGZ 01981 8 11 RERMKRIEEGIK ELGS QILKEHP- -VE- -NTQLQNEKLYLYYLQNGRDMYVDQEL- -D- -INRLSDYDVDHI 874

AKA60242 7 78 RERMKRIEEGIK ELGS QILKEHP- -VE- -NTQLQNEKLYLYYLQNGRDMYVDQEL- -D- -INRLSDYDVDAI 841

AKS40380 7 78 RERMKRIEEGIK ELGS QILKEHP- -VE- -NTQLQNEKLYLYYLQNGRDMYVDQEL- -D- -INRLSDYDVDHI 841

4UN5 B 7 82 RERMKRIEEGIK ELGS QILKEHP- -VE- -NTQLQNEKLYLYYLQNGRDMYVDQEL- -D- -INRLSDYDVDAI 845

WP 010922251 842 VPQSFLKDDSIDNKVLTRSDKNRG-^■KSDN--VP s--EEWKK KN-^■YWRQLLNAKLITQRKFDNLTKA--ERG|GLSE| 910

WP ^"039695303 852 IPQAFIKDDSIDNRVLTSSAKNRG- ^■KSDD- -VP s- -LDIVRARKA- ^■EWVRLYKSGLISKRKFDNLTKA- -ERGGLTE 920

WP ^"045635197 844 IPQAFIKDDSLDNRVLTSSKDNRG- ^■KSDN- -VP s- -IEWQKRKA- ^■FWQQLLDSKLISERKFNNLTKA- -ERGGLDE 912

5AXW A 562 IPRSVSFDNSFNNKVLVKQEEASK- ^■KGNR- -TP Fqy-LSSSDSKI- ^■SYETFKKHILNLAKGKGRISKTk -KEYLLEE 632

WP 009880683 526 VPQSFLKDDSIDNKVLTRSDKNRG- ^■KSDN- -VP s- -EEWKKMKN- -YWKQLLNAKLITQRKFDNLTKA- -ERGGLSE 594

WP ^"010922251 842 VPQSFLKDDSIDNKVLTRSDKNRG- ^■KSDN- -VP s- -EEWKKMKN- -YWRQLLNAKLITQRKFDNLTKA- -ERGGLSE 910

WP ^"011054416 842 VPQSFLKDDSIDNKVLTRSDKNRG- ^■KSDN- -VP s- -EEWKKMKN- -YWRQLLNAKLITQRKFDNLTKA- -ERGGLSE 910

WP ^"011284745 842 VPQSFIKDDSIDNKVLTRSDKNRG- ^■KSNN- -VP s- -EEWKKMKN- -YWRQLLNAKLITQRKFDNLTKA- -ERGGLSE 910

WP ^"011285506 842 VPQSFLKDDSIDNKVLTRSDKNRG- ^■KSDN- -VP s- -EEWKKMKN- -YWRQLLNAKLITQRKFDNLTKA- -ERGGLSE 910

WP ^"011527619 842 VPQSFIKDDSIDNKVLTRSDKNRG- ^■KSDN- -VP s- -EEWKKMKN- -YWRQLLNAKLITQRKFDNLTKA- -ERGGLSE 910

WP ^"012560673 842 VPQSFLKDDSIDNKVLTRSDKNRG- ^■KSDN- -VP s- -EEWKKMKN- -YWKQLLNAKLITQRKFDNLTKA- -ERGGLSE 910

WP ^"014407541 841 VPQSFIKDDSIDNKVLTRSDKNRG- ^■KSDN- -VP s- -EEWKKMKN- -YWRQLLNAKLITQRKFDNLTKA- -ERGGLSE 909

WP ^"020905136 842 VPQSFIKDDSIDNKVLTRSDKNRG- ^■KSDN- -VP s- -EEWKKMKN- -YWRQLLNAKLITQRKFDNLTKA- -ERGGLSE 910

WP ^"023080005 841 VPQSFLKDDSIDNKVLTRSDKNRG- ^■KSDN- -VP s- -EEWKKMKN- -YWRQLLNAKLITQRKFDNLTKA- -ERGGLSE 909

WP ^"023610282 841 VPQSFLKDDSIDNKVLTRSDKNRG- ^■KSDN- -VP s- -EEWKKMKN- -YWRQLLNAKLITQRKFDNLTKA- -ERGGLSE 909

WP ^"030125963 842 VPQSFIKDDSIDNKVLTRSDKNRG- ^■KSDN- -VP s- -EEWKKMKN- -YWRQLLNAKLITQRKFDNLTKA- -ERGGLSE 910

WP ^"030126706 842 VPQSFLKDDSIDNKVLTRSDKNRG- ^■KSDN- -VP s- -EEWKKMKN- -YWRQLLNAKLITQRKFDNLTKA- -ERGGLSE 910

WP ^"031488318 842 VPQSFIKDDSIDNKVLTRSDKNRG- ^■KSDN- -VP s- -EEWKKMKN- -YWKQLLNAKLITQRKFDNLTKA- -ERGGLSE 910

WP ^"032460140 842 VPQSFLKDDSIDNKVLTRSDKNRG- ^■KSDN- -VP s- -EEWKKMKN- -YWKQLLNAKLITQRKFDNLTKA- -ERGGLSE 910

WP ^"032461047 842 VPQSFLKDDSIDNKVLTRSDKNRG- ^■KSDN- -VP s- -EEWKKMKN- -YWKQLLNAKLITQRKFDNLTKA- -ERGGLSE 910

WP ^"032462016 842 VPQSFLKDDSIDNKVLTRSDKNRG- ^■KSDN- -VP s- -EEWKKMKN- -YWRQLLNAKLITQRKFDNLTKA- -ERGGLSE 910

WP ^"032462936 842 VPQSFLKDDSIDNKVLTRSDKNRG- ^■KSDN- -VP s- -EEWKKMKN- -YWKQLLNAKLITQRKFDNLTKA- -ERGGLSE 910

WP ^"032464890 842 VPQSFIKDDSIDNKVLTRSDKNRG- ^■KSDN- -VP s- -EEWKKMKN- -YWRQLLNAKLITQRKFDNLTKA- -ERGGLSE 910

WP ^"033888930 667 VPQSFLKDDSIDNKVLTRSDKNRG- ^■KSDN- -VP s- -EEWKKMKN- -YWRQLLNAKLITQRKFDNLTKA- -ERGGLSE 735

WP ^"038431314 842 VPQSFLKDDSIDNKVLTRSDKNRG- ^■KSDN- -VP s- -EEWKKMKN- -YWRQLLNAKLITQRKFDNLTKA- -ERGGLSE 910

WP ^"038432938 841 VPQSFLKDDSIDNKVLTRSDKNRG- ^■KSDN- -VP s- -EEWKKMKN- -YWRQLLNAKLITQRKFDNLTKA- -ERGGLSE 909

WP ^"038434062 842 VPQSFLKDDSIDNKVLTRSDKNRG- ^■KSDN- -VP s- -EEWKKMKN- -YWKQLLNAKLITQRKFDNLTKA- -ERGGLSE 910

BAQ51233 753 VPQSFLKDDSIDNKVLTRSDKNRG- ^■KSDN- -VP s- -EEWKKMKN- -YWRQLLNAKLITQRKFDNLTKA- -ERGGLSE 821

KGE60162 17 VPQSFLKDDSIDNKVLTRSDKNRG- ^■KSDN- -VP s- -EEWKKMKN- -YWRQLLNAKLITQRKFDNLTKA- -ERGGLSE 85

KGE60856

WP 002989955 842 VPQSFIKDDSIDNKVLTRSDKNRG- ^■KSDN- -VP s- -EEWKKMKN- -YWRQLLNAKLITQRKFDNLTKA- -ERGGLSE 910

WP ^"003030002 841 IPQAFIKDNSLDNRVLTRSDKNRG- ^■KSDD- -VP s- -IEWHEMKS- ^■FWSKLLSVKLITQRKFDNLTKA- -ERGGLTE 909

WP ^"003065552 852 IPQAFIKDDSIDNRVLTSSAKNRG- ^■KSDD- -VP s- -LDIVRARKA- ^■EWVRLYKSGLISKRKFDNLTKA- -ERGGLTE 920

WP ^"001040076 847 IPQAFIKDDSIDNRVLVSSAKNRG- ^■KSDD- -VP s- -LEIVKDCKV- ^■FWKKLLDAKLMSQRKYDNLTKA- -ERGGLTS 915

WP ^"001040078 847 IPQAFIKDDSIDNRVLVSSAKNRG- ^■KSDD- -VP s- -LEIVKDCKV- ^■FWKKLLDAKLMSQRKYDNLTKA- -ERGGLTS 915

WP ^"001040080 847 IPQAFIKDDSIDNRVLVSSAKNRG- ^■KSDD- -VP s- -LEIVKDCKV- ^■FWKKLLDAKLMSQRKYDNLTKA- -ERGGLTS 915

WP ^"001040081 847 IPQAFIKDDSIDNRVLVSSAKNRG- ^■KSDD- -VP s- -LEIVKDCKV- ^■FWKKLLDAKLMSQRKYDNLTKA- -ERGGLTS 915

WP ^"001040083 847 IPQAFIKDDSIDNRVLVSSAKNRG- ^■KSDD- -VP s- -LEIVKDCKV- ^■FWKKLLDAKLMSQRKYDNLTKA- -ERGGLTS 915

WP ^"001040085 847 IPQAFIKDDSIDNRVLVSSAKNRG- ^■KSDD- -VP s- -LEIVKDCKV- ^■FWKKLLDAKLMSQRKYDNLTKA- -ERGGLTS 915

WP 001040087 847 IPQAFIKDDSIDNRVLVSSAKNRG-KSDD—VP s--LEIVKDCKV-^■FWKKLLDAKLMSQRKYDNLTKA--ERGGLTS 915

WP 001040088 847 IPQAFIKDDSIDNRVLVSSAKNRG-KSDD—VP s- -LEIVKDCKV- ^■FWKKLLDAKLMSQRKYDNLTKA- -ERGGLTS 915

WP 001040089 847 IPQAFIKDDSIDNRVLVSSAKNRG-KSDD—VP s- -LEIVKDCKV- ^■FWKKLLDAKLMSQRKYDNLTKA- -ERGGLTS 915

WP 001040090 847 IPQAFIKDDSIDNRVLVSSAKNRG-KSDD—VP s- -LEIVKDCKV- ^■FWKKLLDAKLMSQRKYDNLTKA- -ERGGLTS 915

WP 001040091 847 IPQAFIKDDSIDNRVLVSSAKNRG-KSDD—VP s- -LEIVKDCKV- ^■FWKKLLDAKLMSQRKYDNLTKA- -ERGGLTS 915

WP 001040092 847 VPQAFIKDDSIDNRVLVSSAKNRG-KSDD—VP s- -IDIVKARKA- ^■FWKKLLDAKLISQRKYDNLTKA- -ERGGLTP 915

WP 001040094 847 IPQAFIKDDSIDNRVLVSSAKNRG-KSDD—VP s- -VEIVKDCKV- ^■FWKKLLDAKLMSQRKYDNLTKA- -ERGGLTS 915

WP 001040095 847 IPQAFIKDDSIDNRVLVSSAKNRG-KSDD—VP s- -LEIVKDCKV- ^■FWKKLLDAKLMSQRKYDNLTKA- -ERGGLTS 915

WP 001040096 847 IPQAFIKDDSIDNRVLVSSAKNRG-KSDD—VP s- -LEIVKDCKV- ^■FWKKLLDAKLMSQRKYDNLTKA- -ERGGLTS 915

WP 001040097 847 IPQAFIKDDSIDNRVLVSSAKNRG-KSDD—VP s- -VEIVKDCKV- ^■FWKKLLDAKLMSQRKYDNLTKA- -ERGGLTS 915

WP 001040098 847 IPQAFIKDDSIDNRVLVSSAKNRG-KSDD—VP s- -VEIVKDCKV- ^■FWKKLLDAKLMSQRKYDNLTKA- -ERGGLTS 915

WP 001040099 847 IPQAFIKDDSIDNRVLVSSAKNRG-KSDD—VP s- -VEIVKDCKV- ^■FWKKLLDAKLMSQRKYDNLTKA- -ERGGLTS 915

WP 001040100 847 IPQAFIKDDSIDNRVLVSSAKNRG-KSDD—VP s- -VEIVKDCKV- ^■FWKKLLDAKLMSQRKYDNLTKA- -ERGGLTS 915

WP 001040104 847 IPQAFIKDDSIDNRVLVSSAKNRG-KSDD—VP s- -LEIVKDCKV- ^■FWKKLLDAKLMSQRKYDNLTKA- -ERGGLTS 915

WP 001040105 847 IPQAFIKDDSIDNRVLVSSAKNRG-KSDD—VP s- -LEIVKDCKV- ^■FWKKLLDAKLMSQRKYDNLTKA- -ERGGLTS 915

WP 001040106 847 VPQAFIKDDSIDNRVLVSSAKNRG-KSDN—VP s- -IDIVKARKA- ^■FWKKLLDAKLMSQRKYDNLTKA- -ERGGLTS 915

WP 001040107 847 VPQAFIKDDSIDNRVLVSSAKNRG-KSDN—VP s- -IDIVKARKA- ^■FWKKLLDAKLMSQRKYDNLTKA- -ERGGLTS 915

WP 001040108 847 VPQAFIKDDSIDNRVLVSSAKNRG-KSDN—VP s- -IDIVKARKA- ^■FWKKLLDAKLMSQRKYDNLTKA- -ERGGLTS 915

WP 001040109 847 VPQAFIKDDSIDNRVLVSSAKNRG-KSDN—VP s- -IDIVKARKA- ^■FWKKLLDAKLMSQRKYDNLTKA- -ERGGLTS 915

WP 001040110 847 VPQAFIKDDSIDNRVLVSSAKNRG-KSDN—VP s- -IDIVKARKA- ^■FWKKLLDAKLMSQRKYDNLTKA- -ERGGLTS 915

WP 015058523 847 VPQAFIKDDSIDNRVLVSSAKNRG-KSDD—VP s- -IDIVKARKA- ^■FWKKLLDAKLISQRKYDNLTKA- -ERGGLTP 915

WP 017643650 847 IPQAFIKDDSIDNRVLVSSAKNRG-KSDD—VP s- -VEIVKDCKV- ^■FWKKLLDAKLMSQRKYDNLTKA- -ERGGLTS 915

WP 017647151 847 IPQAFIKDDSIDNRVLVSSAKNRG-KSDD—VP s- -LEIVKDCKV- ^■FWKKLLDAKLMSQRKYDNLTKA- -ERGGLTS 915

WP 017648376 847 IPQAFIKDDSIDNRVLVSSAKNRG-KSDD—VP s- -LEIVKDCKV- ^■FWKKLLDAKLMSQRKYDNLTKA- -ERGGLTS 915

WP 017649527 847 IPQAFIKDDSIDNRVLVSSAKNRG-KSDD—VP s- -LEIVKDCKV- ^■FWKKLLDAKLMSQRKYDNLTKA- -ERGGLTS 915

WP 017771611 847 VPQAFIKDDSIDNRVLVSSAKNRG-KSDN—VP s- -IDIVKARKA- ^■FWKKLLDAKLMSQRKYDNLTKA- -ERGGLTS 915

WP 017771984 847 IPQAFIKDDSIDNRVLVSSAKNRG-KSDD—VP s- -LEIVKDCKV- ^■FWKKLLDAKLMSQRKYDNLTKA- -ERGGLTS 915

CFQ25032 847 IPQAFIKDDSIDNRVLVSSAKNRG-KSDD—VP s- -LEIVKDCKV- ^■FWKKLLDAKLMSQRKYDNLTKA- -ERGGLTS 915

CFV16040 847 IPQAFIKDDSIDNRVLVSSAKNRG-KSDD—VP s- -LEIVKDCKV- ^■FWKKLLDAKLMSQRKYDNLTKA- -ERGGLTS 915

KLJ37842 847 IPQAFIKDDSIDNRVLVSSAKNRG-KSDD—VP s- -LEIVKDCKV- ^■FWKKLLDAKLMSQRKYDNLTKA- -ERGGLTS 915

KLJ72361 847 IPQAFIKDDSIDNRVLVSSAKNRG-KSDD—VP s- -LEIVKDCKV- ^■FWKKLLDAKLMSQRKYDNLTKA- -ERGGLTS 915

KLL20707 861 IPQAFIKDDSIDNRVLVSSAKNRG-KSDD—VP s- -LEIVKDCKV- ^■FWKKLLDAKLMSQRKYDNLTKA- -ERGGLTS 929

KLL42645 847 VPQAFIKDDSIDNRVLVSSAKNRG-KSDN—VP s- -IDIVKARKA- ^■FWKKLLDAKLMSQRKYDNLTKA- -ERGGLTS 915

WP 047207273 847 IPQAFIKDDSIDNRVLVSSAKNRG-KSDD—VP s- -LEIVKDCKV- ^■FWKKLLDAKLMSQRKYDNLTKA- -ERGGLTS 915

WP 047209694 847 IPQAFIKDDSIDNRVLVSSAKNRG-KSDD—VP s- -VEIVKDCKV- ^■FWKKLLDAKLMSQRKYDNLTKA- -ERGGLTS 915

WP 050198062 847 IPQAFIKDDSIDNRVLVSSAKNRG-KSDD—VP s- -LEIVKDCKV- ^■FWKKLLDAKLMSQRKYDNLTKA- -ERGGLTS 915

WP 050201642 847 IPQAFIKDDSIDNRVLVSSAKNRG-KSDD—VP s- -LEIVKDCKV- ^■FWKKLLDAKLMSQRKYDNLTKA- -ERGGLTS 915

WP 050204027 847 VPQAFIKDDSIDNRVLVSSAKNRG-KSDN—VP s- -IDIVKARKA- ^■FWKKLLDAKLMSQRKYDNLTKA- -ERGGLTS 915

WP 050881965 847 IPQAFIKDDSIDNRVLVSSAKNRG-KSDD—VP s- -LEIVKDCKV- ^■FWKKLLDAKLMSQRKYDNLTKA- -ERGGLTS 915

WP 050886065 847 I PQAFIKDDSIDNRVLVSSAKNRG-'KSDD--VP s--LEIVKDCKV-^■FWKKLLDAKLMSQRKYDNLTKA--ERGGLTS 915

AHN30376 847 VPQAFIKDDSIDNRVLVSSAKNRG- ^■KSDD- -VP s- -IDIVKARKA- ^■FWKKLLDAKLISQRKYDNLTKA- -ERGGLTP 915

EA078426 847 I PQAFIKDDSIDNRVLVSSAKNRG- ^■KSDD- -VP s- -LEIVKDCKV- ^■FWKKLLDAKLMSQRKYDNLTKA- -ERGGLTS 915

CCW42055 847 I PQAFIKDDSIDNRVLVSSAKNRG- ^■KSDD- -VP s- -LEIVKDCKV- ^■FWKKLLDAKLMSQRKYDNLTKA- -ERGGLTS 915

WP 003041502 841 IPQAYIKDDSFDNRVLTSSSENRG- ^■KSDN- -VP s- -1EWCARKA- ^■DWMRLRKAGLISQRKFDNLTKA- -ERGGLTE 909

WP 037593752 842 I PQAFIKDNSLDNRVLTRSDKNRG- ^■KSDD- -VP s- -IEWHEMKS- ^■FWSKLLSVKLITQRKFDNLTKA- -ERGGLTE 910

WP 049516684 842 I PQAFIKDNSLDNRVLTRSDKNRG- ^■KSDD- -VP s- -IEWHEMKS- ^■FWSKLLSVKLITQRKFDNLTKA- -ERGGLTE 910

GAD46167 841 I PQAFIKDNSLDNRVLTRSDKNRG- ^■KSDD- -VP s- -IEWHEMKS- ^■FWSKLLSVKLITQRKFDNLTKA- -ERGGLTE 909

WP 018363470 850 I PQAFIKDDSIDNRVLTSSAKNRG- ^■KSDD- -VP s- -LGIVRARKA- ^■EWVRLYKSGLISKRKFDNLTKA- -ERGGLTE 918

WP 003043819 851 VPQSFIKDDSIDNKVLTRSVENRG- ^■KSDN- -VP s- -EEWKKMKN- ^■YWRQLLNAKLITQRKFDNLTKA- -ERGGLSE 919

WP 006269658 841 IPQAFIKDNSLDNRVLTRSDKNRG- ^■KSDD- -VP s- -IEWHEMKS- ^■FWSKLLSVKLITQRKFDNLTKA- -ERGGLTE 909

WP 048800889 841 I PQAFIKDDSIDNRVLTSSAKNRG- ^■KSDN- -VP N- -LEWCDRKA- ^■DWIRLREAGLISQRKFDNLTKA- -ERGGLTE 909

WP 012767106 841 VPQSFIKDDSIDNKILTRSDKNRG- ^■KSDN- -VP s- -EEWKKMKN- ^■YWRQLLNAKLITQRKFDNLTKA- -ERGGLSE 909

WP 014612333 841 VPQSFIKDDSIDNKVLTRSDKNRG- ^■KSDN- -VP s- -EEWKKMKN- ^■YWRQLLNAKLITQRKFDNLTKA- -ERGGLSE 909

WP 015017095 841 VPQSFIKDDSIDNKVLTRSDKNRG- ^■KSDD- -VP s- -EEWKKMKN- ^■YWRQLLNAKLITQRKFDNLTKA- -ERGGLSE 909

WP 015057649 841 VPQSFIKDDSIDNKVLTRSDKNRG- ^■KSDN- -VP s- -EEWKKMKN- ^■YWRQLLNAKLITQRKFDNLTKA- -ERGGLSE 909

WP 048327215 841 VPQSFIKDDSIDNKVLTRSDKNRG- ^■KSDD- -VP s- -EEWKKMKN- ^■YWRQLLNAKLITQRKFDNLTKA- -ERGGLSE 909

WP 049519324 841 VPQSFIKDDSIDNKVLTRSDKNRG- ^■KSDN- -VP s- -EEWKKMKN- ^■YWRQLLNAKLITQRKFDNLTKA- -ERGGLSE 909

WP 012515931 841 IPQSFIKNNSIDNKVLTSQGANRG- ^■KLDN- -VP s- -EAIVRKMKG- ^■YWQSLLRAGAISKQKFDNLTKA- -ERGGLTQ 909

WP 021320964 841 IPQSFIKNNSIDNKVLTSQGANRG- ^■KLDN- -VP s- -EAIVRKMKG- ^■YWQSLLRAGAISKQKFDNLTKA- -ERGGLTQ 909

WP 037581760 841 IPQSFIKNNSIDNKVLTSQGANRG- ^■KLDN- -VP s- -EAIVRKMKG- ^■YWQSLLRAGAISKQKFDNLTKA- -ERGGLTQ 909

WP 004232481 849 I PQAFIKDNSIDNRVLTSSAKNRG- ^■KSDD- -VP s- -IEIVRNRKS- ^■YWYKLYKSGLISKRKFDNLTKA- -ERGGLTE 917

WP 009854540 850 I PQAFIKDDSIDNRVLTSSAKNRG- ^■KSDD- -VP s- -LDIVRARKA- ^■EWVRLYKSGLISKRKFDNLTKA- -ERGGLTE 918

WP 012962174 850 I PQAFIKDDSIDNRVLTSSAKNRG- ^■KSDD- -VP s- -LDIVHDRKA- ^■DWIRLYKSGLISKRKFDNLTKA- -ERGGLTE 918

WP 039695303 852 I PQAFIKDDSIDNRVLTSSAKNRG- ^■KSDD- -VP s- -LDIVRARKA- ^■EWVRLYKSGLISKRKFDNLTKA- -ERGGLTE 920

WP 014334983 849 I PQAFIKDNSIDNKVLTSSAKNRG- ^■KSDD- -VP s- -IEIVRNRRS- ^■YWYKLYKSGLISKRKFDNLTKA- -ERGGLTE 917

WP 003099269 842 I PQSFIKDNSIDNTVLTTQASNRG- ^■KSDN- -VP N- -IETVNKMKS- ^■FWYKQLKSGAISQRKFDHLTKA- -ERGALSD 910

AHY15608 842 I PQSFIKDNSIDNTVLTTQASNRG- ^■KSDN- -VP N- -IETVNKMKS- ^■FWYKQLKSGAISQRKFDHLTKA- -ERGALSD 910

AHY17476 842 I PQSFIKDNSIDNTVLTTQASNRG- ^■KSDN- -VP N- -IETVNKMKS- ^■FWYKQLKSGAISQRKFDHLTKA- -ERGALSD 910

ESR09100

AGM98575 842 I PQSFIKDNSIDNTVLTTQASNRG- ^■KSDN- -VP N- -IETVNKMKS- ^■FWYKQLKSGAISQRKFDHLTKA- -ERGALSD 910

ALF27331 842 I PQAFIKDNSIDNRVLTSSKENRG- ^■KSDD- -VP s- -KDWRKMKS- ^■YWSKLLSAKLITQRKFDNLTKA- -ERGGLTD 910

WP 018372492 858 VPRSYIKNDSFDNKVLTTSKGNRK- ^■KLDD- -VP A- -KEWEKMEN- ^■TWRRLHAAGLISDIKLSYLMKGe LTE 923

WP 045618028 845 I PQAFIKDDSLDNRVLTSSKDNRG- ^■KSDN- -VP s- -LEIVQKRKA- ^■FWQQLLDSKLISERKFNNLTKA- -ERGGLDE 913

WP 045635197 844 I PQAFIKDDSLDNRVLTSSKDNRG- ^■KSDN- -VP s- -IEWQKRKA- ^■FWQQLLDSKLISERKFNNLTKA- -ERGGLDE 912

WP 002263549 842 I PQAFIKDNSIDNRVLTSSKENRG- ^■KSDD- -VP s- -KDWRKMKS- ^■YWSKLLSAKLITQRKFDNLTKA- -ERGGLTD 910

WP 002263887 842 I PQAFIKDNSIDNRVLTSSKENRG- ^■KSDD- -VP s- -KDWRKMKS- ^■YWSKLLSAKLITQRKFDNLTKA- -ERGGLTD 910

WP 002264920 842 I PQAFIKDNSIDNRVLTSSKENRG- ^■KSDD- -VP s- -KDWRKMKS- ^■YWSKLLSAKLITQRKFDNLTKG- -ERGGLTD 910

WP 002269043 842 I PQAFIKDNSIDNRVLTSSKENRG- ^■KSDD- -VP s- -KDWRKMKS- ^■YWSKLLSAKLITQRKFDNLTKA- -ERGGLTD 910

WP 002269448 842 IPQAFIKDNSIDNRVLTSSKENRG-^■KSDD--VP s--EDWRKMKS--YWSKLLSAKLITQRKFDNLTKA--ERGGLTD 910

WP ^"002271977 842 IPQAFIKDNSIDNRVLTSS KENRG- ^■KSDD- -VP s- -KDWRKMKS- -YWSKLLSAKLITQRKFDNLTKA- -ERGGLTD 910

WP ^"002272766 842 IPQAFIKDNSIDNRVLTSS KENRG- ^■KSDD- -VP s- -KDWRKMKP- -YWSKLLSAKLITQRKFDNLTKA- -ERGGLTD 910

WP ^"002273241 842 IPQAFIKDNSIDNRVLTSS KENRG- ^■KSDD- -VP s- -KDWRKMKS- -YWSKLLSAKLITQRKFDNLTKA- -ERGGLTD 910

WP ^"002275430 842 IPQAFIKDNSIDNRVLTSS KENRG- ^■KSDD- -VP s- -KDWRKMKP- -YWSKLLSAKLITQRKFDNLTKA- -ERGGLTD 910

WP ^"002276448 842 IPQAFIKDNSIDNRVLTSS KENRG- ^■KSDD- -VP s- -KDWRKMKS- -YWSKLLSAKLITQRKFDNLTKA- -ERGGLTD 910

WP ^"002277050 847 IPQAFIKDNSIDNRVLTSS KANRG- ^■KSDD- -VP s- -EDWNRMRP- -FWNKLLSSGLISQRKYNNLTKK- -E LTP 912

WP ^"002277364 842 IPQAFIKDNSIDNRVLTSS KENRG- ^■KSDD- -VP s- -KNWRKMKS- -YWSKLLSAKLITQRKFDNLTKA- -ERGGLTD 910

WP ^"002279025 842 IPQAFIKDNSIDNRVLTSS KENRG- ^■KSDD- -VP s- -KDWRKMKP- -YWSKLLSAKLITQRKFDNLTKA- -ERGGLTD 910

WP ^"002279859 842 IPQAFIKDNSIDNRVLTSS KENRG- ^■KSDD- -VP s- -KDWRKMKS- -YWSKLLSAKLITQRKFDNLTKG- -ERGGLTD 910

WP ^"002280230 842 IPQAFIKDNSIDNRVLTSS KENRG- ^■KSDD- -VP s- -KDWRKMKS- -YWSKLLSAKLITQRKFDNLTKA- -ERGGLTD 910

WP ^"002281696 842 IPQAFIKDNSIDNRVLTSS KENRG- ^■KSDD- -VP s- -KNWRKMKS- -YWSKLLSAKLITQRKFDNLTKA- -ERGGLTD 910

WP ^"002282247 847 IPQAFIKDNSIDNRVLTSS KANRG- ^■KSDD- -VP s- -EDWNRMRP- -FWNKLLSSGLISQRKYNNLTKK- -E LTL 912

WP ^"002282906 842 IPQAFIKDNSIDNRVLTSS KENRG- ^■KSDD- -VP s- -KDWRKMKS- -YWSKLLSAKLITQRKFDNLTKA- -ERGGLTD 910

WP ^"002283846 842 IPQAFIKDNSIDNRVLTSS KENRG- ^■KSDD- -VP s- -KNWRKMKS- -YWSKLLSAKLITQRKFDNLTKA- -ERGGLTD 910

WP ^"002287255 842 IPQAFIKDNSIDNRVLTSS KENRG- ^■KSDD- -VP s- -KNWRKMKS- -YWSKLLSAKLITQRKFDNLTKA- -ERGGLTD 910

WP ^"002288990 842 IPQAFIKDNSIDNRVLTSS KENRG- ^■KSDD- -VP s- -KDWRKMKS- -YWSKLLSAKLITQRKFDNLTKA- -ERGGLTD 910

WP ^"002289641 842 IPQAFIKDNSIDNRVLTSS KENRG- ^■KSDD- -VP s- -KDWRKMKS- -YWSKLLSAKLITQRKFDNLTKA- -ERGGLTD 910

WP ^"002290427 842 IPQAFIKDNSIDNRVLTSS KENRG- ^■KSDD- -VP s- -KDWRKMKS- -YWSKLLSAKLITQRKFDNLTKG- -ERGGLTD 910

WP ^"002295753 842 IPQAFIKDNSIDNRVLTSS KENRG- ^■KSDD- -VP s- -KDWRKMKS- -YWSKLLSAKLITQRKFDNLTKA- -ERGGLTD 910

WP ^"002296423 842 IPQAFIKDNSIDNRVLTSS KENRG- ^■KSDD- -VP s- -KNWRKMKS- -YWSKLLSAKLITQRKFDNLTKA- -ERGGLTD 910

WP ^"002304487 856 IPQAFIKDNSIDNRVLTRS DKNRG- ^■KSDD- -VP s- -EEWHKMKP- -FWSKLLSAKLITQRKFDNLTKA- -ERGGLTD 924

WP ^"002305844 842 IPQAFIKDNSIDNRVLTSS KENRG- ^■KSDD- -VP s- -KDWRKMKS- -YWSKLLSAKLITQRKFDNLTKA- -ERGGLTD 910

WP ^"002307203 842 IPQAFIKDNSIDNRVLTSS KENRG- ^■KSDD- -VP s- -KDWRKMKS- -YWSKLLSAKLITQRKFDNLTKA- -ERGGLTD 910

WP ^"002310390 842 IPQAFIKDNSIDNRVLTSS KENRG- ^■KSDD- -VP s- -KDWRKMKS- -YWSKLLSAKLITQRKFDNLTKG- -ERGGLTD 910

WP ^"002352408 842 IPQAFIKDNSIDNRVLTSS KENRG- ^■KSDD- -VP s- -KDWRKMKS- -YWSKLLSAKLITQRKFDNLTKA- -ERGGLTD 910

WP ^"012997688 842 IPQAFIKDNSIDNRVLTSS KENRG- ^■KSDD- -VP s- -KNWRKMKS- -YWSKLLSAKLITQRKFDNLTKA- -ERGGLTD 910

WP ^"014677909 842 IPQAFIKDNSIDNRVLTSS KENRG- ^■KSDD- -VP s- -KDWRKMKS- -YWSKLLSAKLITQRKFDNLTKA- -ERGGLTD 910

WP ^"019312892 842 IPQAFIKDNSIDNRVLTSS KENRG- ^■KSDD- -VP s- -KNWRKMKS- -YWSKLLSAKLITQRKFDNLTKA- -ERGGLTD 910

WP ^"019313659 842 IPQAFIKDNSIDNRVLTSS KENRG- ^■KSDD- -VP s- -KDWRKMKS- -YWSKLLSAKLITQRKFDNLTKA- -ERGGLTD 910

WP ^"019314093 842 IPQAFIKDNSIDNRVLTSS KENRG- ^■KSDD- -VP s- -KDWRKMKS- -YWSKLLSAKLITQRKFDNLTKA- -ERGGLTD 910

WP ^"019315370 842 IPQAFIKDNSIDNRVLTSS KENRG- ^■KSDD- -VP s- -KDWRKMKP- -YWSKLLSAKLITQRKFDNLTKA- -ERGGLTD 910

WP ^"019803776 842 IPQAFIKDNSIDNRVLTSS KENRG- ^■KSDD- -VP s- -KDWRKMKS- -YWSKLLSAKLITQRKFDNLTKA- -ERGGLTD 910

WP ^"019805234 842 IPQAFIKDNSIDNRVLTSS KENRG- ^■KSDD- -VP s- -KDWRKMKS- -YWSKLLSAKLITQRKFDNLTKG- -ERGGLTD 910

WP ^"024783594 842 IPQAFIKDNSIDNRVLTSS KENRG- ^■KSDD- -VP s- -KDWRKMKS- -YWSKLLSAKLITQRKFDNLTKA- -ERGGLTD 910

WP ^"024784288 847 IPQAFIKDNSIDNRVLTSS KANRG- ^■KSDD- -VP s- -EDWNRMRP- -FWNKLLSSGLISQRKYNNLTKK- -E LTL 912

WP ^"024784666 842 IPQAFIKDNSIDNRVLTSS KENRG- ^■KSDD- -VP s- -KNWRKMKS- -YWSKLLSAKLITQRKFDNLTKA- -ERGGLTD 910

WP ^"024784894 842 IPQAFIKDNSIDNRVLTSS KENRG- ^■KSDD- -VP s- -KDWRKMKS- -YWSKLLSAKLITQRKFDNLTKA- -ERGGLTD 910

WP ^"024786433 847 IPQAFIKDNSIDNRVLTSS KANRG- ^■KSDD- -VP s- -EDWNRMRP- -FWNKLLSSGLISQRKYNNLTKK- -E LTL 912

WP 049473442 842 IPQAFIKDNSIDNRVLTSSKENRG-^■KSDD--VP s--KDWRKMKP-^■YWSKLLSAKLITQRKFDNLTKA--ERGGLTD 910

WP 049474547 842 IPQAFIKDNSIDNRVLTSSKENRG- ^■KSDD- -VP s- -KDWRKMKS- ^■YWSKLLSAKLITQRKFDNLTKA- -ERGGLTD 910

EMC03581 835 IPQAFIKDNSIDNRVLTSSKENRG- ^■KSDD- -VP s- -KNWRKMKS- ^■YWSKLLSAKLITQRKFDNLTKA- -ERGGLTD 903

WP 000428612 847 VPQAFIKDDSLDNRVLTSLKDNRG- ^■KSDN- -VP s- -LEWEKMKT- ^■FWQQLLDSKLISYRKFNNLTKA- -ERGGLDE 915

WP 000428613 845 VPQAFIKDDSLDNRVLTSLKDNRG- ^■KSDN- -VP s- -IEWQKRKA- ^■FWQQLLDSKLISERKFNNLTKA- -ERGGLDE 913

WP 049523028 840 IPQAFIKDDSLDNRVLTSSKDNRG- ^■KSDN- -VP s- -LEIVEKMKG- ^■FWQQLLDSKLISERKFNNLTKA- -ERGGLDE 908

WP 003107102 811 IPQSFIKDNSIDNIVLTSQESNRG- ^■KSDN- -VP Y- -IAIVNKMKS- ^■YWQHQLKSGAISQRKFDNLTKA- -ERGGLSE 879

WP 054279288 843 IPRSFIKDDSIDNKVLTRSEHNRG- ^■KTDN- -VP s- -IEWKRMKP- ^■YWQKLLDTKVISQRKFDNLTKA- -ERGGLQE 911

WP 049531101 845 IPQAFIKDDSLDNRVLTSSKDNRG- ^■KSDN- -VP s- -LEWQKRKA- ^■FWQQLLESKLISERKFNNLTKA- -ERGGLNE 913

WP 049538452 845 IPQAFIKDDSLDNRVLTSSKENRG- ^■KSDN- -VP c- -LEWDKMKV- ^■FWQQLLDFKLISYRKFNNLTKA- -ERGGLDE 913

WP 049549711 845 IPQAFIKDDSLDNRVLTSSKDNRG- ^■KSDN- -VP s- -LEWQKRKA- ^■FWQQLLDSKLISERKFNNLTKAerERDGLNE 915

WP 007896501 847 IPQSFIKDNSIDNLVLTTQKANRG- ^■KSDN- -VP s- -IEWRDMKDrVWRRQLANGAISRQKFDHLTKA- -ERGGLAD 916

EFR44625 799 IPQSFIKDNSIDNLVLTTQKANRG- ^■KSDN- -VP s- -IEWRDMKDrVWRRQLANGAISRQKFDHLTKA- -ERGGLAD 868

WP 002897477 844 IPQAFIKDDSIDNRVLTSSKDNRG- ^■KSDN- -VP s- -LEWQKRKA- ^■FWQQLLDSKLISERKFNNLTKA- -ERGGLDE 912

WP 002906454 844 IPQAFIKDDSLDNRVLTSSKDNRG- ^■KSDN- -VP s- -IEWQKRKA- ^■FWQQLLDSKLISERKFNNLTKA- -KRGGLDE 912

WP 009729476 845 IPQAFIKDDSLDNRVLTSSKDNRG- ^■KSDN- -VP s- -LEWDKMKV- ^■FWQQLLDSKLISYRKFNNLTKA- -ERGGLNE 913

CQR24647 844 IPQSFIKDNSLDNRVLTNSKSNRG- ^■KSDN- -VP s- -NEWKRMKG- ^■FWLKQLDAKLISQRKFDNLTKA- -ERGGLSA 912

WP 000066813 847 IPQAFIKDDSLDNRVLTSSKDNRG- ^■KSDN- -VP s- -LEWEKMKA- ^■FWQQLLDSKLISERKFNNLTKAerERGGLNE 917

WP 009754323 845 IPQAFIKDDSLDNRVLTSSKDNRG- ^■KSDN- -VP s- -LEWKKRKA- ^■FWQQLLDSKLISERKFNNLTKA- -ERGGLDE 913

WP 044674937 844 IPQAFIKDDSLDNKVLTKSAKNRG- ^■KSDD- -VP s- -LEIVHKKKN- ^■FWKQLLDSQLISQRKFDNLTKA- -ERGGLTN 912

WP 044676715 846 IPQAFIKDDSLDNKVLTKSAKNRG- ^■KSDD- -VP s- -LEIVHKKKN- ^■FWKQLLDSQLISQRKFDNLTKA- -ERGGLTN 914

WP 044680361 846 IPQAFIKDDSLDNKVLTKSAKNRG- ^■KSDD- -VP s- -LEIVHKKKN- ^■FWKQLLDSQLISQRKFDNLTKA- -ERGGLTN 914

WP 044681799 844 IPQAFIKDDSLDNKVLTKSAKNRG- ^■KSDD- -VP s- -LEIVHKKKN- ^■FWKQLLDSQLISQRKFDNLTKA- -ERGGLTN 912

WP 049533112 841 IPQAFIKDDSFDNRVLTSSSENRG- ^■KSDN- -VP s- -1EWRARKA- ^■DWMRLRKAGLISQRKFDNLTKA- -ERGGLTE 909

WP 029090905 824 LPQSYIKDNSIENLALVKKVENQR- ^■KKDS11LN s- —SIINQNYS- ^■RWEQLKNAGLIGEKKFRNLTRTk ITD 890

WP 006506696 850 VPQSLVKDDSFDNRVLWPSENQR- ^■KLDDlvVP — -FDIRDKMYR- ^■FWKLLFDHELISPKKFYSLIKTe YTE 916

AIT42264 842 VPQSFLKDDSIDNKVLTRSDKNRG- ^■KSDN- -VP s- -EEWKKMKN- ^■YWRQLLNAKLITQRKFDNLTKA- -ERGGLSE 910

WP 034440723 849 IPRSFITDNSFDNLVLTSSTVNRG- ^■KLDN- -VP Sp —DIVRQQKG- ^■FWKQLLRAGLMSQRKFNNLTKGk LTD 914

AKQ21048 842 VPQSFLKDDSIDNKVLTRSDKNRG- ^■KSDN- -VP s- -EEWKKMKN- ^■YWRQLLNAKLITQRKFDNLTKA- -ERGGLSE 910

WP 004636532 846 IPQSFTTDNSIDNKVLVSRTKNQGnKSDD- -VP s- -INIVHKMKP- ^■FWRQLHKAGLISDRKFKNLTKA- -EHGGLTE 915

WP 002364836 853 IPQSFMKDDSLDNLVLVGSTENRG- ^■KSDD- -VP s- -KEWKDMKA- ^■YWEKLYAAGLISQRKFQRLTKG- -EQGGLTL 921

WP 016631044 804 IPQSFMKDDSLDNLVLVGSTENRG- ^■KSDD- -VP s- -KEWKDMKA- ^■YWEKLYAAGLISQRKFQRLTKG- -EQGGLTL 872

EMS75795 589 IPRSFIVDNSIDNKVLVSSKENRL- ^■KMDD- -VP D- -QKWIRMRR- ^■YWEKLLRANLISERKFAYLTKLe LTP 654

WP 002373311 853 IPQSFMKDDSLDNLVLVGSTENRG- ^■KSDD- -VP s- -KKWKKMKA- ^■YWEKLYAAGLISQRKFQRLTKG- -EQGGLTL 921

WP 002378009 853 IPQSFMKDDSLDNLVLVGSTENRG- ^■KSDD- -VP s- -KEWKDMKA- ^■YWEKLYAAGLISQRKFQRLTKG- -EQGGLTL 921

WP 002407324 853 IPQSFMKDDSLDNLVLVGSTENRG- ^■KSDD- -VP s- -KEWKDMKA- ^■YWEKLYAAGLISQRKFQRLTKG- -EQGGLTL 921

WP 002413717 853 IPQSFMKDDSLDNLVLVGSTENRG- ^■KSDD- -VP s- -KEWKDMKA- ^■YWEKLYAAGLISQRKFQRLTKG- -EQGGLTL 921

WP 010775580 855 IPQSFMKDDSLDNLVLVGSTENRG- ^■KSDD- -VP s- -KEWKKMKA- ^■YWEKLYAAGLISQRKFQRLTKG- -EQGGLTL 923

WP 010818269 853 IPQSFMKDDSLDNLVLVGSTENRG- ^■KSDD- -VP s- -KEWKDMKA- ^■YWEKLYAAGLISQRKFQRLTKG- -EQGGLTL 921

WP 010824395 853 IPQSFMKDDSLDNLVLVGSTENRG-^■KSDD--VP s--KEWKDMKA-YWEKLYAAGLISQRKFQRLTKG--^■EQGGLTL 921

WP ^"016622645 853 IPQSFMKDDSLDNLVLVGSTENRG- ^■KSDD- -VP s- -KEWKDMKA- YWEKLYAAGLISQRKFQRLTKG-- ^■EQGGLTL 921

WP ^"033624816 853 IPQSFMKDDSLDNLVLVGSTENRG- ^■KSDD- -VP s- -KEWKKMKA- YWEKLYAAGLISQRKFQRLTKG-- ^■EQGGLTL 921

WP ^"033625576 853 IPQSFMKDDSLDNLVLVGSTENRG- ^■KSDD- -VP s- -KEWKKMKA- YWEKLYAAGLISQRKFQRLTKG-- ^■EQGGLTL 921

WP ^"033789179 853 IPQSFMKDDSLDNLVLVGSTENRG- ^■KSDD- -VP s- -KEWKKMKA- YWEKLYAAGLISQRKFQRLTKG-- ^■EQGGLTL 921

WP ^"002310644 853 IPRSFTTDNSIDNKVLVSSKENRL- ^■KKDD- -VP s- -EKWKKMRS- FWYDLYSSKLISKRKLDNLTKIk- LTE 918

WP ^"002312694 854 IPRSFTTDNSIDNKVLVSSKENRL- ^■KKDD- -VP s- -EKWKKMRS- FWYDLYSSKLISKRKLDNLTKIk- LTE 919

WP ^"002314015 854 IPRSFTTDNSIDNKVLVSSKENRL- ^■KKDD- -VP s- -EKWKKMRS- FWYDLYSSKLISKRKLDNLTKIk- LTE 919

WP ^"002320716 854 IPRSFTTDNSIDNKVLVSSKENRL- ^■KKDD- -VP s- -EKWKKMRS- FWYDLYSSKLISKRKLDNLTKIk- LTE 919

WP ^"002330729 853 IPRSFTTDNSIDNKVLVSSKENRL- ^■KKDD- -VP s- -EKWKKMRS- FWYDLYSSKLISKRKLDNLTKIk- LTE 918

WP ^"002335161 854 IPRSFTTDNSIDNKVLVSSKENRL- ^■KKDD- -VP s- -EKWKKMRS- FWYDLYSSKLISKRKLDNLTKIk- LTE 919

WP ^"002345439 854 IPRSFTTDNSIDNKVLVSSKENRL- ^■KKDD- -VP s- -EKWKKMRS- FWYDLYSSKLISKRKLDNLTKIk- LTE 919

WP ^"034867970 845 IPRSFIVDNSIDDKVLVASKQNQK- ^■KRDD- -VP K- -KQIVNEQRI- FWNQLKEAKLISTKKYAYLTKIe- LTP 910

WP ^"047937432 854 IPRSFTTDNSIDNKVLVSSKENRL- ^■KKDD- -VP s- -EKWKKMRS- FWYDLYSSKLISKRKLDNLTKIk- LTE 919

WP ^"010720994 845 IPRSFIVDNSIDNKVLVASKQNQK- ^■KRDD- -VP K- -KQIVNEQRI- FWNQLKEAKLISPKKYAYLTKIe- LTP 910

WP ^"010737004 845 IPRSFIVDNSIDNKVLVASKQNQK- ^■KRDD- -VP K- -KQIVNEQRI- FWNQLKEAKLISPKKYAYLTKIe- LTP 910

WP ^"034700478 845 IPRSFIVDNSIDNKVLVASKQNQK- ^■KRDD- -VP N- -KQIVNEQRI- FWNQLKEAKLISPKKYAYLTKIe- LTP 910

WP ^"007209003 846 IPQSFLTDNSIDNRVLTTSKSNRG- ^■KSDN- -VP s- -EEWRKMDR- FWRKLLNAKLISERKYTNLTKKe- LTE 911

WP ^"023519017 839 IPRSFIVDNSLDNKVLVSSKVNRG- ^■KLDN- -AP D- -PLWKRMRS- HWEKLHQAKLISDKKLANLTKQn- LTE 904

WP ^"010770040 846 VPQSFTTDNSLDNRVLVSSKENRG- ^■KKDD- -VP s- -KEWQKNIT- LWETLKNSNLISQKKYDNLTKG-- ^■LRGGLTE 914

WP ^"048604708 843 I PQSFIVDNSLDNRVLVSSSKNRG- ^■KLDD- -VP s- -KEWKKMRA- FWESLYRSGLISKKKFDNLVKA-- ^■ESGGLSE 911

WP ^"010750235 848 IPRSFIVDHSLDNKVLVSSKENRL- ^■KKDD- -VP D- -SKWKRMKA- YWEKLLRANLISERKFSYLTKLe- LTD 913

AII16583 881 VPQSFLKDDSIDNKVLTRSDKNRG- ^■KSDN- -VP s- -EEWKKMKN- YWRQLLNAKLITQRKFDNLTKA-- ^■ERGGLSE 949

WP 029073316 861 VPQSLLKDDSIDNKVLVLSSENQR- ^■KLDDlvIP — -EMIRNKMFG- FWNKLYENKIISPKKFYSLIKSe- YSD 927

WP ^"031589969 861 VPQSLLKDDSIDNKVLVLSSENQR- ^■KLDDlvIP — -SSIRNKMYG- FWEKLFNNKIISPKKFYSLIKTe- FNE 927

KDA45870 834 IPQSFLKDDSIENKVLTIKKENVR- ^■KTNG- -LP s- -EAVIQKMGS- FWKKLLDAGAMTNKKYDNLRRNl- ^■-HGGLNE 902

WP 039099354 857 LPQSFIKDNSLDNRVLVSQRMNRS- ^■KADQ- -VP s- -VELGQKMQI- QWEQMLRAGLITKKKYDNLTLNp- 923

AKP02966 859 LPRTYIPDDSLENKALVLAKENQR- ^■KADD11LN s- —NVIDKNLE- RWTYMLNNNMMGLKKFKNLTRRv- ITD 925

WP 010991369 845 VPQSFITDNSIDNLVLTSSAGNRE- ^■KGDD- -VP P- -LEIVRKRKV- FWEKLYQGNLMSKRKFDYLTKA-- ^■ERGGLTE 913

WP ^"033838504 845 VPQSFITDNSIDNLVLTSSAGNRE- ^■KGDD- -VP P- -LEIVRKRKV- FWEKLYQGNLMSKRKFDYLTKA-- ^■ERGGLTE 913

EHN60060 848 VPQSFITDNSIDNLVLTSSAGNRE- ^■KGDD- -VP P- -LEIVRKRKV- FWEKLYQGNLMSKRKFDYLTKA-- ^■ERGGLTE 916

EFR89594 614 VPQSFITDNSIDNLVLTSSAGNRE- ^■KGND- -VP P- -LEIVQKRKV- FWEKLYQGNLMSKRKFDYLTKA-- ^■ERGGLTE 682

WP 038409211 845 IPQSFITDNSIDNRVLVSSTANRE- ^■KGDN- -VP L- -LEWRKRKA- FWEKLYQAKLMSKRKFDYLTKA-- ^■ERGGLTE 913

EFR95520 464 IPQSFITDNSIDNRVLVSSTANRE- ^■KGDN- -VP L- -LEWRKRKA- FWEKLYQAKLMSKRKFDYLTKA-- ^■ERGGLTE 532

WP 003723650 845 VPQSFITDNSIDNLVLTSSAGNRE- ^■KGGD- -VP P- -LEIVRKRKV- FWEKLYQGNLMSKRKFDYLTKA-- ^■ERGGLTE 913

WP ^"003727705 845 VPQSFITDNSIDNLVLTSSAGNRE- ^■KGGD- -VP P- -LEIVRKRKV- FWEKLYQGNLMSKRKFDYLTKA-- ^■ERGGLTE 913

WP ^"003730785 845 VPQSFITDNSIDNLVLTSSAGNRE- ^■KGGD- -VP P- -LEIVRKRKV- FWEKLYQGNLMSKRKFDYLTKA-- ^■ERGGLTE 913

WP ^"003733029 845 VPQSFITDNSVDNLVLTSSAGNRE- ^■KGDN- -VP P- -LEIVQKRKI- FWEKLYQGNLMSKRKFDYLTKA-- ^■ERGGLTE 913

WP ^"003739838 845 VPQSFITDNSIDNLVLTSSAGNRE- ^■KGDD- -VP P- -LEIVRKRKV- FWEKLFQGNLMSKRKFDYLTKA-- ^■ERGGLTE 913

WP 014601172 845 VPQSFITDNSIDNLVLTSSAGNRE- KGGD--VP P--LEIVRKRKV- FWEKLYQGNLMSKRKFDYLTKA--ERGGLTD 913

WP 023548323 845 VPQSFITDNSIDNLVLTSSAGNRE- KGDN- -VP P- -LEIVQKRKI- FWEKLYQGNLMSKRKFDYLTKA- -ERGGLTE 913

WP 031665337 845 VPQSFITDNSIDNLVLTSSAGNRE- KGGD- -VP P- -LEIVRKRKV- FWEKLYQGNLMSKRKFDYLTKA- -ERGGLTE 913

WP 031669209 845 VPQSFITDNSVDNLVLTSSAGNRE- KGDN- -VP P- -LEIVQKRKI- FWEKLYQGNLMSKRKFDYLTKA- -ERGGLTE 913

WP 033920898 845 VPQSFITDNSIDNLVLTSSAGNRE- KGDN- -VP P- -LEIVQKRKI- FWEKLYQGNLMSKRKFDYLTKA- -ERGGLTE 913

AKI42028 848 VPQSFITDNSIDNLVLTSSAGNRE- ^■KGGD- -VP P- -LEIVRKRKV- FWEKLYQGNLMSKRKFDYLTKA- -ERGGLTD 916

AKI50529 848 VPQSFITDNSIDNLVLTSSAGNRE- ^■KGDN- -VP P- -LEIVQKRKI- ^■FWEKLYQGNLMSKRKFDYLTKA- -ERGGLTE 916

EFR83390 293 VPQSFITDNSIDNLVLTSSAGNRE- ^■KGDD- -VP P- -LEIVRKRKV- ^■FWEKLYQGNLMSKRKFDYLTKA- -ERGGLTE 361

WP 046323366 845 VPQSFITDNSIDNRVLASSAANRE- ^■KGDN- -VP s- -LEWRKRKV- ^■YWEKLYQAKLMSKRKFDYLTKA- -ERGGLTE 913

AKE81011 858 VPQSFLKDDSIDNKVLTRSDKNRG- ^■KSDN- -VP s- -EEWKKMKN- ^■YWRQLLNAKLITQRKFDNLTKA- -ERGGLSE 926

CU082355 854 VPQSLVKDDSFDNRVLVLPSENQR- ^■KLDDlvVP — -FDIRDKMYR- ^■FWKLLFDHELISPKKFYSLIKTe YTE 920

WP 033162887 856 LPQSLIKDDSFDNRVLVLPEENQW- ^■KLDSetVP — -FEIRNKMIG- ^■FWQMLHENGLMSNKKFFSLIRTd FSD 922

AGZ 01981 875 VPQSFLKDDSIDNKVLTRSDKNRG- ^■KSDN- -VP s- -EEWKKMKN- ^■YWRQLLNAKLITQRKFDNLTKA- -ERGGLSE 943

AKA60242 842 VPQSFLKDDSIDNKVLTRSDKNRG- ^■KSDN- -VP s- -EEWKKMKN- ^■YWRQLLNAKLITQRKFDNLTKA- -ERGGLSE 910

AKS40380 842 VPQSFLKDDSIDNKVLTRSDKNRG- ^■KSDN- -VP s- -EEWKKMKN- ^■YWRQLLNAKLITQRKFDNLTKA- -ERGGLSE 910

4UN5 B 846 VPQSFLKDDSIDNKVLTRSDKNRG- ^■KSDN- -VP s- -EEWKKMKN- ^■YWRQLLNAKLITQRKFDNLTKA- -ERGGLSE 914

WP 010922251 911 |LD KAGFIKRQLVETRQITKHVAQILDSRMNTKYDENDKLIR--EVKVITLKSKLVSDFRKDF QFYKVREINNY| 981

WP ^"039695303 921 AD KAGFIKRQLVETRQITKHVAQILDARFNTEHDENDKVIR- -DVKVITLKSNLVSQFRKDF EFYKVREINDY 9 91

WP ^"045635197 913 RD KVGFIKRQLVETRQITKHVAQILDARYNTEVNEKDKKNR- -TVKIITLKSNLVSNFRKEF RLYKVREINDY 9 83

5AXW A 633 RD QKDFINRNLVDTRYATRGLMNLLRSYFR nlDVKVKSINGGFTSFLRRKW KFKKERNKGYK 7 02

WP 009880683 595 LD KAGFIKRQLVETRQITKHVAQILDSRMNTKYDENDKLIR- -EVRVITLKSKLVSDFRKDF QFYKVREINNY 6 65

WP ^"010922251 911 LD KAGFIKRQLVETRQITKHVAQILDSRMNTKYDENDKLIR- -EVKVITLKSKLVSDFRKDF QFYKVREINNY 9 81

WP ^"011054416 911 LD KVGFIKRQLVETRQITKHVAQILDSRMNTKYDENDKLIR- -EVRVITLKSKLVSDFRKDF QFYKVREINNY 9 81

WP ^"011284745 911 LD KAGFIKRQLVETRQITKHVAQILDSRMNTKYDENDKLIR- -EVKVITLKSKLVSDFRKDF QFYKVREINNY 9 81

WP ^"011285506 911 LD KAGFIKRQLVETRQITKHVAQILDSRMNTKYDENDKLIR- -EVKVITLKSKLVSDFRKDF QFYKVREINNY 9 81

WP ^"011527619 911 LD KAGFIKRQLVETRQITKHVAQILDSRMNTKYDENDKLIR- -EVKVITLKSKLVSDFRKDF QFYKVREINNY 9 81

WP ^"012560673 911 LD KAGFIKRQLVETRQITKHVAQILDSRMNTKYDENDKLIR- -EVRVITLKSKLVSDFRKDF QFYKVREINNY 9 81

WP ^"014407541 910 LD KAGFIKRQLVETRQITKHVAQILDSRMNTKYDENDKLIR- -EVKVITLKSKLVSDFRKDF QFYKVREINNY 9 80

WP ^"020905136 911 LD KAGFIKRQLVETRQITKHVAQILDSRMNTKYDENDKLIR- -EVKVITLKSKLVSDFRKDF QFYKVREINNY 9 81

WP ^"023080005 910 LD KAGFIKRQLVETRQITKHVAQILDSRMNTKYDENDKLIR- -EVKVITLKSKLVSDFRKDF QFYKVREINNY 9 80

WP ^"023610282 910 LD KAGFIKRQLVETRQITKHVAQILDSRMNTKYDENDKLIR- -EVKVITLKSKLVSDFRKDF QFYKVREINNY 9 80

WP ^"030125963 911 LD KAGFIKRQLVETRQITKHVAQILDSRMNTKYDENDKLIR- -EVKVITLKSKLVSDFRKDF QFYKVREINNY 9 81

WP ^"030126706 911 LD KAGFIKRQLVETRQITKHVAQILDSRMNTKYDENDKLIR- -EVKVITLKSKLVSDFRKDF QFYKVREINNY 9 81

WP ^"031488318 911 LD KAGFIKRQLVETRQITKHVAQILDSRMNTKYDENDKLIR- -EVKVITLKSKLVSDFRKDF QFYKVREINNY 9 81

WP ^"032460140 911 LD KAGFIKRQLVETRQITKHVAQILDSRMNTKYDENDKLIR- -EVRVITLKSKLVSDFRKDF QFYKVREINNY 9 81

WP ^"032461047 911 LD KAGFIKRQLVETRQITKHVAQILDSRMNTKYDENDKLIR- -EVRVITLKSKLVSDFRKDF QFYKVREINNY 9 81

WP ^"032462016 911 LD KAGFIKRQLVETRQITKHVAQILDSRMNTKYDENDKLIR- -EVKVITLKSKLVSDFRKDF QFYKVREINNY 9 81

WP ^"032462936 911 LD KAGFIKRQLVETRQITKHVAQILDSRMNTKYDENDKLIR- -EVRVITLKSKLVSDFRKDF QFYKVREINNY 9 81

WP ^"032464890 911 LD KAGFIKRQLVETRQITKHVAQILDSRMNTKYDENDKLIR- -EVKVITLKSKLVSDFRKDF QFYKVREINNY 9 81

WP ^"033888930 736 LD KAGFIKRQLVETRQITKHVAQILDSRMNTKYDENDKLIR- -EVKVITLKSKLVSDFRKDF QFYKVREINNY 8 06

WP ^"038431314 911 LD KAGFIKRQLVETRQITKHVAQILDSRMNTKYDENDKLIR- -EVKVITLKSKLVSDFRKDF QFYKVREINNY 9 81

WP ^"038432938 910 LD KAGFIKRQLVETRQITKHVAQILDSRMNTKYDENDKLIR- -EVKVITLKSKLVSDFRKDF QFYKVREINNY 9 80

WP ^"038434062 911 LD KAGFIKRQLVETRQITKHVAQILDSRMNTKYDENDKLIR- -EVKVITLKSKLVSDFRKDF QFYKVREINNY 9 81

BAQ51233 822 LD KAGFIKRQLVETRQITKHVAQILDSRMNTKYDENDKLIR- -EVKVITLKSKLVSDFRKDF QFYKVREINNY 8 92

KGE60162 86 LD KVGFIKRQLVETRQITKHVAQILDSRMNTKYDENDKLIR- -EVRVITLKSKLVSDFRKDF QFYKVREINNY 1 56 KGE60856

WP 002989955 911 LD KAGFIKRQLVETRQITKHVAQILDSRMNTKYDENDKLIR- -EVKVITLKSKLVSDFRKDF QFYKVREINNY 9 81

WP 003030002 910 ED KAGFIKRQLVETRQITKHVAQILDERFNTEFDGNKRRIR- -NVKIITLKSNLVSNFRKEF ELYKVREINDY 9 80

WP ^"003065552 921 AD KAGFIKRQLVETRQITKHVAQILDARFNTESDENDKVIR- -DVKVITLKSNLVSQFRKDF EFYKVREINDY 9 91

WP ^"001040076 916 DD KARFIQRQLVETRQITKHVARILDERFNNELDSKGRRIR- -KVKIVTLKSNLVSNFRKEF VFYKIREVNNY 9 86

WP ^"001040078 916 DD KARFIQRQLVETRQITKHVARILDERFNNELDSKGRRIR- -KVKIVTLKSNLVSNFRKEF GFYKIREVNDY 9 86

WP ^"001040080 916 DD KARFIQRQLVETRQITKHVARILDERFNNELDSKGRRIR- -KVKIVTLKSNLVSNFRKEF GFYKIREVNNY 9 86

WP ^"001040081 916 DD KARFIQRQLVETRQITKHVARILDERFNNELDSKGRRIR- -KVKIVTLKSNLVSNFRKEF GFYKIREVNNY 9 86

WP ^"001040083 916 DD KARFIQRQLVETRQITKHVARILDERFNNELDSKGRRIR- -KVKIVTLKSNLVSNFRKEF GFYKIREVNNY 9 86

WP ^"001040085 916 DD KARFIQRQLVETRQITKHVARILDERFNNELDSKGRRIR- -KVKIVTLKSNLVSNFRKEF GFYKIREVNNY 9 86

WP 001040087 916 DD KARFIQRQLVETRQITKHVARILDERFNNELDSKGRRIR--KVKIVTLKSNLVSNFRKEF GFYKIREVNNY 9E36

WP 001040088 916 DD KARFIQRQLVETRQITKHVARILDERFNNELDSKGRRIR- -KVKIVTLKSNLVSNFRKEF GFYKIREVNNY 9E 36

WP 001040089 916 DD KARFIQRQLVETRQITKHVARILDERFNNELDSKGRRIR- -KVKIVTLKSNLVSNFRKEF GFYKIREVNNY 9E 36

WP 001040090 916 DD KARFIQRQLVETRQITKHVARILDERFNNELDSKGRRIR- -KVKIVTLKSNLVSNFRKEF GFYKIREVNNY 9E 36

WP 001040091 916 DD KARFIQRQLVETRQITKHVARILDERFNNELDSKGRRIR- -KVKIVTLKSNLVSNFRKEF GFYKIREVNNY 9E 36

WP 001040092 916 DD KAGFIQRQLVETRQITKHVARILDERFNNKVDDNNKPIR- -KVKIVTLKSNLVSNFRKEF GFYKIREVNNY 9E 36

WP 001040094 916 DD KARFIQRQLVETRQITKHVARILDERFNNELDSKGRRIR- -KVKIVTLKSNLVSNFRKEF GFYKIREVNNY 9E 36

WP 001040095 916 DD KARFIQRQLVETRQITKHVARILDERFNNELDSKGRRIR- -KVKIVTLKSNLVSNFRKEF GFYKIREVNNY 9E 36

WP 001040096 916 DD KARFIQRQLVETRQITKHVARILDERFNNELDSKGRRIR- -KVKIVTLKSNLVSNFRKEF GFYKIREVNNY 9E 36

WP 001040097 916 DD KARFIQRQLVETRQITKHVARILDERFNNELDSKGRRIR- -KVKIVTLKSNLVSNFRKEF GFYKIREVNNY 9E 36

WP 001040098 916 DD KARFIQRQLVETRQITKHVARILDERFNNELDSKGRRIR- -KVKIVTLKSNLVSNFRKEF GFYKIREVNNY 9E 36

WP 001040099 916 DD KARFIQRQLVETRQITKHVARILDERFNNELDSKGRRIR- -KVKIVTLKSNLVSNFRKEF GFYKIREVNNY 9E 36

WP 001040100 916 DD KARFIQRQLVETRQITKHVARILDERFNNELDSKGRRIR- -KVKIVTLKSNLVSNFRKEF GFYKIREVNNY 9E 36

WP 001040104 916 DD KARFIQRQLVETRQITKHVARILDERFNNELDSKGRRIR- -KVKIVTLKSNLVSNFRKEF GFYKIREVNNY 9E 36

WP 001040105 916 DD KARFIQRQLVETRQITKHVARILDERFNNELDSKGRRIR- -KVKIVTLKSNLVSNFRKEF GFYKIREVNNY 9E 36

WP 001040106 916 DD KARFIQRQLVETRQITKHVARILDERFNNELDSKGRRIR- -KVKIVTLKSNLVSNFRKEF GFYKIREVNDY 9E 36

WP 001040107 916 DD KARFIQRQLVETRQITKHVARILDERFNNELDSKGRRIR- -KVKIVTLKSNLVSNFRKEF GFYKIREVNDY 9E 36

WP 001040108 916 DD KARFIQRQLVETRQITKHVARILDERFNNELDSKGRRIR- -KVKIVTLKSNLVSNFRKEF GFYKIREVNDY 9E 36

WP 001040109 916 DD KARFIQRQLVETRQITKHVARILDERFNNELDSKGRRIR- -KVKIVTLKSNLVSNFRKEF GFYKIREVNDY 9E 36

WP 001040110 916 DD KARFIQRQLVETRQITKHVARILDERFNNELDSKGRRIR- -KVKIVTLKSNLVSNFRKEF GFYKIREVNDY 9E 36

WP 015058523 916 DD KAGFIQRQLVETRQITKHVARILDERFNNKVDDNNKPIR- -KVKIVTLKSNLVSNFRKEF GFYKIREVNNY 9E 36

WP 017643650 916 DD KARFIQRQLVETRQITKHVARILDERFNNELDSKGRRIR- -KVKIVTLKSNLVSNFRKEF GFYKIREVNNY 9E 36

WP 017647151 916 DD KARFIQRQLVETRQITKHVARILDERFNNELDSKGRRIR- -KVKIVTLKSNLVSNFRKEF GFYKIREVNNY 9E 36

WP 017648376 916 DD KARFIQRQLVETRQITKHVARILDERFNNELDSKGRRIR- -KVKIVTLKSNLVSNFRKEF GFYKIREVNNY 9E 36

WP 017649527 916 DD KARFIQRQLVETRQITKHVARILDERFNNELDSKGRRIR- -KVKIVTLKSNLVSNFRKEF GFYKIREVNNY 9E 36

WP 017771611 916 DD KARFIQRQLVETRQITKHVARILDERFNNELDSKGRRIR- -KVKIVTLKSNLVSNFRKEF GFYKIREVNDY 9E 36

WP 017771984 916 DD KARFIQRQLVETRQITKHVARILDERFNNELDSKGRRIR- -KVKIVTLKSNLVSNFRKEF GFYKIREVNNY 9E 36

CFQ25032 916 DD KARFIQRQLVETRQITKHVARILDERFNNELDSKGRRIR- -KVKIVTLKSNLVSNFRKEF GFYKIREVNNY 9E 36

CFV16040 916 DD KARFIQRQLVEIRQITKHVARILDERFNNELDSKGRRIR- -KVKIVTLKSNLVSNFRKEF GFYKIREVNNY 9E 36

KLJ37842 916 DD KARFIQRQLVETRQITKHVARILDERFNNELDSKGRRIR- -KVKIVTVKSNLVSNFRKEF GFYKIREVNNY 9E 36

KLJ72361 916 DD KARFIQRQLVETRQITKHVARILDELFNNELDSKGRRIR- -KVKIVTLKSNLVSNFRKEF GFYKIREVNNY 9E 36

KLL20707 930 DD KARFIQRQLVETRQITKHVARILDERFNNELDSKGRRIR- -KVKIVTLKSNLVSNFRKEF GFYKIREVNNY 1000

KLL42645 916 DD KARFIQRQLVETRQITKHVARILDERFNNELDSKGRRIR- -KVKIVTLKSNLVSNFRKEF GFYKIREVNDY 9E 36

WP 047207273 916 DD KARFIQRQLVETRQITKHVARILDERFNNELDSKGRRIR- -KVKIVTLKSNLVSNFRKEF GFYKIREVNNY 9E 36

WP 047209694 916 DD KARFIQRQLVETRQITKHVARILDERFNNELDSKGRRIR- -KVKIVTLKSNLVSNFRKEF GFYKIREVNNY 9E 36

WP 050198062 916 DD KARFIQRQLVETRQITKHVARILDERFNNELDSKGRRIR- -KVKIVTLKSNLVSNFRKEF GFYKIREVNNY 9E 36

WP 050201642 916 DD KARFIQRQLVETRQITKHVASILDERFNNELDSKGRRIR- -KVKIVTLKSNLVSNFRKEF GFYKIREVNNY 9E 36

WP 050204027 916 DD KARFIQRQLVETRQITKHVARILDERFNNELDSKGRRIR- -KVKIVTLKSNLVSNFRKEF GFYKIREVNDY 9E 36

WP 050881965 916 DD KARFIQRQLVETRQITKHVARILDERFNNELDSKGRRIR- -KVKIVTLKSNLVSNFRKEF GFYKIREVNNY 9E 36

WP 050886065 916 DD KARFIQRQLVETRQITKHVARILDERFNNELDSKGRRIR--KVKIVTLKSNLVSNFRKEF GFYKIREVNNY 986

AHN30376 916 DD KAGFIQRQLVETRQITKHVARILDERFNNKVDDNNKPIR- -KVKIVTLKSNLVSNFRKEF GFYKIREVNNY 9 86

EA078426 916 DD KARFIQRQLVETRQITKHVARILDERFNNELDSKGRRIR- -KVKIVTLKSNLVSNFRKEF GFYKIREVNNY 9 86

CCW42055 916 DD KARFIQRQLVETRQITKHVARILDERFNNELDSKGRRIR- -KVKIVTLKSNLVSNFRKEF GFYKIREVNDY 9 86

WP 003041502 910 ND KAGFIKRQLVETRQITKHVAQVLDARFNAKHDENKKVIR- -DVKIITLKSNLVSQFRKDF KFYKVREINDY 9 80

WP ^"037593752 911 ED KAGFIKRQLVETRQITKHVAQILDERFNTEFDGAQRRIR- -NVKIITLKSNLVSNFRKEF ELYKVREINDY 9 81

WP ^"049516684 911 ED KAGFIKRQLVETRQITKHVAQILDERFNTEFDGAQRRIR- -NVKIITLKSNLVSNFRKEF ELYKVREINDY 9 81

GAD46167 910 ED KAGFIKRQLVETRQITKHVAQILDERFNTEFDGAQRRIR- -NVKIITLKSNLVSNFRKEF ELYKVREINDY 9 80

WP 018363470 919 AD KAGFIKRQLVETRQITKHVAQILDARFNTERDENDKVIR- -DVKVITLKSNLVSQFRKEF KFYKVREINDY 9 89

WP ^"003043819 920 AD KAGFIKRQLVETRQITKHVARILDSRMNTKRDKNDKPIR- -EVKVITLKSKLVSDFRKDF QLYKVRDINNY 9 90

WP ^"006269658 910 ED KAGFIKRQLVETRQITKHVAQILDERFNTEFDGNKRRIR- -NVKIITLKSNLVSNFRKEF ELYKVREINDY 9 80

WP ^"048800889 910 ND KAGFIHRQLVETRQITKHVAQILDARFNPKRDDNKKVIR- -DVKIITLKSNLVSQFRRDF KLYKVREINDY 9 80

WP ^"012767106 910 LD KAGFIKRQLVETRQITKHVAQILDSRMNTKYDENDKLIR- -EVKVITLKSKLVSDFRKDF QFYKVREINNY 9 80

WP ^"014612333 910 LD KAGFIKRQLVETRQITKHVAQILDSRMNTKYDENDKLIR- -EVKVITLKSKLVSDFRKDF QFYKVREINNY 9 80

WP ^"015017095 910 LD KAGFIKRQLVETRQITKHVAQILDSRMNTKYDENDKLIR- -EVKVITLKSKLVSDFRKDF QFYKVREINNY 9 80

WP ^"015057649 910 LD KAGFIKRQLVETRQITKHVAQILDSRMNTKYDENDKLIR- -EVKVITLKSKLVSDFRKDF QFYKVREINNY 9 80

WP ^"048327215 910 LD KAGFIKRQLVETRQITKHVAQILDSRMNTKYDENDKLIR- -EVKVITLKSKLVSDFRKDF QFYKVREINNY 9 80

WP ^"049519324 910 LD KAGFIKRQLVETRQITKHVAQILDSRMNTKYDENDKLIR- -EVKVITLKSKLVSDFRKDF QFYKVREINNY 9 80

WP ^"012515931 910 VD KAGFIQRQLVETRQITKHVAQILDSRFNTEFDDHNKRIR- -KVHIITLKSKLVSDFRKEF GLYKIRDINHY 9 80

WP ^"021320964 910 VD KAGFIQRQLVETRQITKHVAQILDSRFNTEFDDHNKRIR- -KVHIITLKSKLVSDFRKEF GLYKIRDINHY 9 80

WP ^"037581760 910 VD KAGFIQLQLVETRQITKHVAQILDSRFNTEFDDHNKRIR- -KVHIITLKSKLVSDFRKEF GLYKIRDINHY 9 80

WP ^"004232481 918 TD KAGFIKRQLVETRQITKHVAQILDARFNTKCDENDKVIR- -DVKVITLKSSLVSQFRKEF KFYKVREINDY 9 88

WP ^"009854540 919 AD KAGFIKRQLVETRQITKHVAQILDARFNTEHDENDKVIR- -DVKVITLKSNLVSQFRKDF EFYKVREINDY 9 89

WP ^"012962174 919 ND KAGFIKRQLVETRQITKHVAQILDSRFNTERDENDKVIR- -NVKVITLKSNLVSQFRKDF KFYKVREINDY 9 89

WP ^"039695303 921 AD KAGFIKRQLVETRQITKHVAQILDARFNTEHDENDKVIR- -DVKVITLKSNLVSQFRKDF EFYKVREINDY 9 91

WP ^"014334983 918 AD KAGFIKRQLVETRQITKHVAQILDARFNTKRDENDKVIR- -DVKVITLKSNLVSQFRKEF KFYKVREINDY 9 88

WP ^"003099269 911 FD KAGFIKRQLVETRQITKHVAQILDSRFNSNLTEDSKSNR- -NVKIITLKSKMVSDFRKDF GFYKLREVNDY 9 81

AHY15608 911 FD KAGFIKRQLVETRQITKHVAQILDSRFNSNLTEDSKSNR- -NVKIITLKSKMVSDFRKDF GFYKLREVNDY 9 81

AHY17476 911 FD KAGFIKRQLVETRQITKHVAQILDSRFNSNLTEDSKSNR- -NVKIITLKSKMVSDFRKDF GFYKLREVNDY 9 81

ESR09100

AGM98575 911 FD KAGFIKRQLVETRQITKHVAQILDSRFNSNLTEDSKSNR- -NVKIITLKSKMVSDFRKDF GFYKLREVNDY 9 81

ALF27331 911 DD KAGFIKRQLVETRQITKHVARILDERFNTETDENNKKIR- -QVKIVTLKSNLVSNFRKEF ELYKVREINDY 9 81

WP 018372492 924 ED KAGFIRRQLVETRQITKHVARLLDEKLNRKKNENGEKLR- -TTKIITLKSVFASRFRANF DLYKLRELNHY 9 94

WP ^"045618028 914 RD KVGFIKRQLVETRQITKHVAQILDARFNTEVTEKDKKDR- -SVKIITLKSNLVSNFRKEF RLYKVREINDY 9 84

WP ^"045635197 913 RD KVGFIKRQLVETRQITKHVAQILDARYNTEVNEKDKKNR- -TVKIITLKSNLVSNFRKEF RLYKVREINDY 9 83

WP ^"002263549 911 DD KAGFIKRQLVETRQITKHVARILDERFNTETDENNKKIR- -QVKIVTLKSNLVSNFRKEF ELYKVREINDY 9 81

WP ^"002263887 911 DD KAGFIKRQLVETRQITKHVARILDERFNTETDENNKKIR- -QVKIVTLKSNLVSNFRKEF ELYKVREINDY 9 81

WP ^"002264920 911 DD KAGFIKRQLVETRQITKHVARILDERFNTETDENNKKIR- -QVKIVTLKSNLVSNFRKEF ELYKVREINDY 9 81

WP ^"002269043 911 DD KAGFIKRQLVETRQITKHVARILDERFNTETDENNKKIR- -QVKIVTLKSNLVSNFRKEF ELYKVREINDY 9 81

WP 002269448 911 DD KAGFIKRQLVETRQITKHVARILDERFYTETDENNKKIR--QVKIVTLKSNLVSNFRKEF ELYKVREINDY 981

WP ^"0022 71977 911 DD KAGFIKRQLVETRQITKHVARILDERFYTETDENNKKIR- -QVKIVTLKSNLVSNFRKEF ELYKVREINDY 9 81

WP ^"0022 72766 911 DD KAGFIKRQLVETRQITKHVARILDERFNTETDENNKKIR- -QVKIVTLKSNLVSNFRKEF ELYKVREINDY 9 81

WP ^"0022 73241 911 DD KAGFIKRQLVETRQITKHVARILDERFYTETDENNKKIR- -QVKIVTLKSNLVSNFRKEF ELYKVREINDY 9 81

WP ^"0022 75430 911 DD KAGFIKRQLVETRQITKHVARILDERFNTETDENNKKIR- -QVKIVTLKSNLVSNFRKEF ELYKVREINDY 9 81

WP ^"0022 76448 911 DD KAGFIKRQLVETRQITKHVARILDERFYTETDENNKKIR- -QVKIVTLKSNLVSNFRKEF ELYKVREINDY 9 81

WP ^"0022 77050 913 DD KAGFIKRQLVETRQITKHVARMLDERFNKEFDDNNKRIR- -RVKIVTLKSNLVSSFRKEF ELYKVREINDY 9 83

WP ^"0022 77364 911 DD KAGFIKRQLVETRQITKHVARILDERFHTETDENNKKIR- -QVKIVTLKSNLVSNFRKEF ELYKVREINDY 9 81

WP ^"0022 79025 911 DD KAGFIKRQLVETRQITKHVARILDERFNTETDENNKKIR- -QVKIVTLKSNLVSNFRKEF ELYKVREINDY 9 81

WP ^"0022 79859 911 DD KAGFIKRQLVETRQITKHVARILDERFNTETDENNKKIR- -QVKIVTLKSNLVSNFRKEF ELYKVREINDY 9 81

WP ^"0022 80230 911 DD KAGFIKRQLVETRQITKHVARILDERFYTETDENNKKIR- -QVKIVTLKSNLVSNFRKEF ELYKVREINDY 9 81

WP ^"0022 81696 911 DD KAGFIKRQLVETRQITKHVARILDERFHTETDENNKKIR- -QVKIVTLKSNLVSNFRKEF ELYKVREINDY 9 81

WP ^"0022 82247 913 DD KAGFIKRQLVETRQITKHVARMLDERFNKEFDDNNKRIR- -RVKIVTLKSNLVSSFRKEF ELYKVREINDY 9 83

WP ^"0022 82906 911 DD KAGFIKRQLVETRQITKHVARILDERFNTETDENNKKIR- -QVKIVTLKSNLVSNFRKEF ELYKVREINDY 9 81

WP ^"0022 83846 911 DD KAGFIKRQLVETRQITKHVARILDERFHTETDENNKKIR- -QVKIVTLKSNLVSNFRKEF ELYKVREINDY 9 81

WP ^"0022 87255 911 DD KAGFIKRQLVETRQITKHVARILDERFHTETDENNKKIR- -QVKIVTLKSNLVSNFRKEF ELYKVREINDY 9 81

WP ^"0022 88990 911 DD KAGFIKRQLVETRQITKHVARILDERFNTETDENNKKIR- -QVKIVTLKSNLVSNFRKEF ELYKVREINDY 9 81

WP ^"0022 89641 911 DD KAGFIKRQLVETRQITKHVARILDERFNTETDENNKKIR- -QVKIVTLKSNLVSNFRKEF ELYKVREINDY 9 81

WP ^"0022 90427 911 DD KAGFIKRQLVETRQITKHVARILDERFNTETDENNKKIR- -QVKIVTLKSNLVSNFRKEF ELYKVREINDY 9 81

WP ^"0022 95753 911 DD KAGFIKRQLVETRQITKHVARILDERFYTETDENNKKIR- -QVKIVTLKSNLVSNFRKEF ELYKVREINDY 9 81

WP ^"0022 96423 911 DD KAGFIKRQLVETRQITKHVARILDERFHTETDENNKKIR- -QVKIVTLKSNLVSNFRKEF ELYKVREINDY 9 81

WP ^"0023 04487 925 DD KAGFIKRQLVETRQITKHVARILDERFNTETDENNKKIR- -QVKIVTLKSNLVSNFRKEF ELYKVREINDY 9 95

WP ^"0023 05844 911 DD KAGFIKRQLVETRQITKHVARILDERFYTETDENNKKIR- -QVKIVTLKSNLVSNFRKEF ELYKVREINDY 9 81

WP ^"0023 07203 911 DD KAGFIKRQLVETRQITKHVARILDERFNTETDENNKKIR- -QVKIVTLKSNLVSNFRKEF ELYKVREINDY 9 81

WP ^"0023 10390 911 DD KAGFIKHQLVETRQITKHVARILDERFNTETDENNKKIR- -QVKIVTLKSNLVSNFRKEF ELYKVREINDY 9 81

WP ^"0023 52408 911 DD KAGFIKRQLVETRQITKHVARILDERFNTETDENNKKIR- -QVKIVTLKSNLVSNFRKEF ELYKVREINDY 9 81

WP ^"0129 97688 911 DD KAGFIKRQLVETRQITKHVARILDERFHTETDENNKKIR- -QVKIVTLKSNLVSNFRKEF ELYKVREINDY 9 81

WP ^"θ146 77909 911 DD KAGFIKRQLVETRQITKHVARILDERFYTETDENNKKIR- -QVKIVTLKSNLVSNFRKEF ELYKVREINDY 9 81

WP ^"0193 12892 911 DD KAGFIKRQLVETRQITKHVARILDERFHTETDENNKKIR- -QVKIVTLKSNLVSNFRKEF ELYKVREINDY 9 81

WP ^"0193 13659 911 DD KAGFIKRQLVETRQITKHVARILDERFHTETDENNKKIR- -QVKIVTLKSNLVSNFRKEF ELYKVREINDY 9 81

WP ^"0193 14093 911 DD KAGFIKRQLVETRQITKHVARILDERFNTETDENNKKIR- -QVKIVTLKSNLVSNFRKEF ELYKVREINDY 9 81

WP ^"0193 15370 911 DD KAGFIKRQLVETRQITKHVARILDERFNTETDENNKKIR- -QVKIVTLKSNLVSNFRKEF ELYKVREINDY 9 81

WP ^"0198 03776 911 DD KAGFIKRQLVETRQITKHVARILDERFNTETDENNKKIR- -QVKIVTLKSNLVSNFRKEF ELYKVREINDY 9 81

WP ^"0198 05234 911 DD KAGFIKRQLVETRQITKHVARILDERFNTETDENNKKIR- -QVKIVTLKSNLVSNFRKEF ELYKVREINDY 9 81

WP ^"0247 83594 911 DD KAGFIKRQLVETRQITKHVARILDERFNTETDENNKKIR- -QVKIVTLKSNLVSNFRKEF ELYKVREINDY 9 81

WP ^"0247 84288 913 DD KAGFIKRQLVETRQITKHVARMLDERFNKEFDDNNKRIR- -RVKIVTLKSNLVSSFRKEF ELYKVREINDY 9 83

WP ^"0247 84666 911 DD KAGFIKRQLVETRQITKHVARILDERFHTETDENNKKIR- -QVKIVTLKSNLVSNFRKEF ELYKVREINDY 9 81

WP ^"0247 84894 911 DD KAGFIKRQLVETRQITKHVARILDERFNTETDENNKKIR- -QVKIVTLKSNLVSNFRKEF ELYKVREINDY 9 81

WP ^"0247 86433 913 DD KAGFIKRQLVETRQITKHVARMLDERFNKEFDDNNKRIR- -RVKIVTLKSNLVSSFRKEF ELYKVREINDY 9 83

WP 049473442 911 DD KAGFIKRQLVETRQITKHVARILDERFNTETDENNKKIR--QVKIVTLKSNLVSNFRKEF ELYKVREINDY 981

WP ^"049474547 911 DD KAGFIKRQLVETRQITKHVARILDERFNTETDENNKKIR- -QVKIVTLKSNLVSNFRKEF ELYKVREINDY 9 81

EMC03581 904 DD KAGFIKRQLVETRQITKHVARILDERFHTETDENNKKIR- -QVKIVTLKSNLVSNFRKEF ELYKVREINDY 9 74

WP 000428612 916 RD KVGFIKRQLVETRQITKHVAQILDARYNTEVNEKDKKNR- -TVKIITLKSNLVSNFRKEF RLYKIREINDY 9 86

WP ^"000428613 914 RD KVGFIKRQLVETRQITKHVAQILDARFNKEVNEKDKKNR- -TVKIITLKSNLVSNFRKEF RLYKVREINDY 9 84

WP ^"049523028 909 RD KVGFIKRQLVETRQITKHVAQILDDRFNAEVNEKNQKLR- -SVKIITLKSNLVSNFRKEF GLYKVREINDY 9 79

WP ^"003107102 880 YD KAGFIKRQLVETRQITKHVAQILNNRFNNNVDDSSKNKR- -PVKIITLKSKMVSDFRKEF GFYKIREVNDY 9 50

WP ^"054279288 912 SD KANFIQRQLVETRQITKHVAQILDSRFNTERDEKDRPIR- -RVKVITLKSKFVSDFRQDF GFYKLREINDY 9 82

WP ^"049531101 914 RD KVGFIKRQLVETRQITKHVAQILDSRFNTKVNEKNQKIR- -TVKIITLKSNLVSNFRKEF RLYKVREINDY 9 84

WP ^"049538452 914 RD KVGFIRRQLVETRQITKHVAQILDSRFNTEVTEKDKKNR- -NVKIITLKSNLVSNFRKEF GLYKVREINDY 9 84

WP ^"049549711 916 LD KVGFIKRQLVETRQITKHVAQILDARFNKEVTEKDKKNR- -NVKIITLKSNLVSNFRKEF RLYKVREINDY 9 86

WP ^"007896501 917 SD KARFLRRQLVETRQITKHVAQLLDSRFNSKSNQNKKLAR- -NVKIITLKSKIVSDFRKDF GLYKLREVNNY 9 87

EFR44625 869 SD KARFLRRQLVETRQITKHVAQLLDSRFNSKSNQNKKLAR- -NVKIITLKSKIVSDFRKDF GLYKLREVNNY 9 39

WP 002897477 913 RD KVGFIRRQLVETQQITKNVAQILDARFNTEVKEKNQKIR- -TVKIITLKSNLVSNFRKEF GLYKVREINNY 9 83

WP ^"002906454 913 RD KVGFIKRQLVETRQITKHVAQLLDTRFNTEVNEENQKIR- -TVKIITLKSNLVSNFRKEF GLYKVREINDY 9 83

WP ^"009729476 914 LD KVGFIKRQLVETRQITKHVAQILDARFNKEVTEKDKKNR- -TVKIITLKSNLVSNFRKEF ELYKVREINDY 9 84

CQR24647 913 ED KAGFIKRQLVETRQITKHVARILDERFNRDFDKNDKRIR- -NVKIVTLKSNLVSNFRKEF GFYKVREINNF 9 83

WP 000066813 918 LD KVGFIKRQLVETRQITKHVAQFLDARFNKEVTEKDKKNR- -NVKIITLKSNLVSNFRKEF GLYKVREINDY 9 88

WP ^"009754323 914 RD KVGFIKRQLVETRQITKHVARILDARFNTEVSEKNQKIR- -SVKIITLKSNLVSNFRKEF KLYKVREINDY 9 84

WP ^"044674937 913 ED KARFIQRQLVETRQITKHVARILDTRFNTKLDEAGNRIRdpKVNIITLKSNLVSQFRKDY QLYKVREINNY 9 85

WP ^"044676715 915 ED KARFIQRQLVETRQITKHVARILDTRFNTKLDEAGNRIRdpKVNIITLKSNLVSQFRKDY QLYKVREINNY 9 87

WP ^"044680361 915 ED KARFIQRQLVETRQITKHVARILDTRFNTKLDEAGNRIRdpKVNIITLKSNLVSQFRKDY QLYKVREINNY 9 87

WP ^"044681799 913 ED KARFIQRQLVETRQITKHVARILDTRFNTKLDEAGNRIRdpKVNIITLKSNLVSQFRKDY QLYKVREINNY 9 85

WP ^"049533112 910 ND KAGFIKRQLVETRQITKHVAQVLDARFNAKHDENKKVIR- -DVKIITLKSNLVSQFRKDF KFYKVREINDY 9 80

WP ^"029090905 891 RD KEGFIARQLVETRQITKHVTQLLQQEY K-dTTKVFAIKATLVSGLRRKF EFIKNRNVNDY 9 51

WP ^"006506696 917 RD EERFINRQLVETRQITKNVTQIIEDHYST —TKVAAIRANLSHEFRVKN HIYKNRDINDY 9 76

AIT42264 911 LD KAGFIKRQLVETRQITKHVAQILDSRMNTKYDENDKLIR- -EVKVITLKSKLVSDFRKDF QFYKVREINNY 9 81

WP 034440723 915 RD RQQFINRQLVETRQITKHVANLLSHHLNEK KEVG- -EINIVLLKSALTSQFRKKF DFYKVREVNDY 9 80

AKQ21048 911 LD KAGFIKRQLVETRQITKHVAQILDSRMNTKYDENDKLIR- -EVKVITLKSKLVSDFRKDF QFYKVREINNY 9 81

WP 004636532 916 AD RAHFLNRQLVETRQITKHVANLLDSQYNTAEEQ R- —INIVLLKSSMTSRFRKEF KLYKVREINDY 9 80

WP ^"002364836 922 ED KAHFIQRQLVETRQITKNVAGILDQRYNANSKE K- -KVQIITLKASLTSQFRSIF GLYKVREVNDY 9 87

WP ^"016631044 873 ED KAHFIQRQLVETRQITKNVAGILDQRYNAKSKE K- -KVQIITLKASLTSQFRSIF GLYKVREVNDY 9 38

EMS75795 655 ED KARFIQRQLVETRQITKHVAAILDQYFN-QPEE-SK-NK- -GIRIITLKSSLVSQFRKTF GINKVREINNH 7 22

WP 002373311 922 ED KAHFIQRQLVETRQITKNVAGILDQRYNAKSKE K- -KVQIITLKASLTSQFRSIF GLYKVREVNDY 9 87

WP ^"002378009 922 ED KAHFIQRQLVETRQITKNVAGILDQRYNAKSKE K- -KVQIITLKASLTSQFRSIF GLYKVREVNDY 9 87

WP ^"002407324 922 ED KAHFIQRQLVETRQITKNVAGILDQRYNAKSKE K- -KVQIITLKASLTSQFRSIF GLYKVREVNDY 9 87

WP ^"002413717 922 ED KAHFIQRQLVETRQITKNVAGILNQRYNANSKE K- -KVQIITLKASLTSQFRSIF GLYKVREVNDY 9 87

WP ^"010775580 924 ED KAHFIQRQLVETRQITKNVAGILDQRYNAKSKE K- -KVQIITLKASLTSQFRSIF GLYKVREVNDY 9 89

WP ^"010818269 922 ED KAHFIQRQLVETRQITKNVAGILDQRYNAKSKE K- -KVQIITLKASLTSQFRSIF GLYKVREVNDY 9 87

WP 010824395 922 ED KAHFIQRQLVETRQITKNVAGILDQLYNAKSKE K—KVQIITLKASLTSQFRSIF GLYKVREVNDY 987

WP 016622645 922 ED KAHFIQRQLVETRQITKNVAGILDQRYNAKSKE K—KVQIITLKASLTSQFRSIF GLYKVREVNDY 987

WP 033624816 922 ED KAHFIQRQLVETRQITKNVAGILDQRYNAKSKE K—KVQIITLKASLTSQFRSIF GLYKVREVNDY 987

WP 033625576 922 ED KAHFIQRQLVETRQITKNVAGILDQRYNAKSKE K—KVQIITLKASLTSQFRSIF GLYKVREVNDY 987

WP 033789179 922 ED KAHFIQRQLVETRQITKNVAGILDQRYNAKSKE K—KVQIITLKASLTSQFRSIF GLYKVREVNDY 987

WP 002310644 919 ED KAGFIKRQLVETRQITKHVAGILHHRFN-KAEDTNEPIR—KVRI ITLKSALVSQFRNRF GIYKVREINEY 988

WP 002312694 920 ED KAGFIKRQLVETRQITKHVAGILHHRFN-KAEDTNDPIR—KVRI ITLKSALVSQFRNRF GIYKVREINEY 989

WP 002314015 920 ED KAGFIKRQLVETRQITKHVAGILHHRFN-KAEDTNEPIR—KVRI ITLKSALVSQFRNRF GIYKVREINEY 989

WP 002320716 920 ED KAGFIKRQLVETRQITKHVAGILHHRFN-KAEDTNEPIR—KVRI ITLKSALVSQFRNRF GIYKVREINEY 989

WP 002330729 919 ED KAGFIKRQLVETRQITKHVAGILHHRFN-KAEDTNEPIR—KVRI ITLKSALVSQFRNRF GIYKVREINEY 988

WP 002335161 920 ED KAGFIKRQLVETRQITKHVAGILHHRFN-KAEDTNEPIR—KVRI ITLKSALVSQFRNRF GIYKVREINEY 989

WP 002345439 920 ED KAGFIKRQLVETRQITKHVAGILHHRFN-KAEDTNEPIR—KVRI ITLKSALVSQFRNRF GIYKVREINEY 989

WP 034867970 911 ED KARFIQRQLVETRQITKHVANILHQSFN-QEEEGTD-CD—GVQI ITLKATLTSQFRQTF GLYKVREINPH 979

WP 047937432 920 ED KAGFIKRQLVETRQITKHVAGILHHRFN-KAEDTNEPIR—KVRI ITLKSALVSQFRNRF GIYKVREINEY 989

WP 010720994 911 ED KARFIQRQLVETRQITKHVANILHQSFN-QEEEGTD-CD—GVQI ITLKATLTSQFRQTF GLYKVREINPH 979

WP 010737004 911 ED KARFIQRQLVETRQITKHVANILHQSFN-QEEEGTD-CD—GVQI ITLKATLTSQFRQTF GLYKVREINPH 979

WP 034700478 911 ED KARFIQRQLVETRQITKHVANILHQSFN-QEEEGTD-CD—GVQI ITLKATLTSQFRQTF GLYKVREINPH 979

WP 007209003 912 SD KAGFLKRQLVETRQITKHVATILDSKFNE—DSNNRDVQ I ITLKSALVSEFRKTF NLYKVREINDL 977

WP 023519017 905 AD KARFIQRQLVETRQITKHVANLLHQHFN-LPEEVSA-TE—KTSIITLKSTLTSQFRQMF DIYKVREINHH 973

WP 010770040 915 DD RAHFIKRQLVETRQITKHVARILDQRFNSQKDEEGKTIR—AVRWTLKSSLTSQFRKQF AIHKVREINDY 985

WP 048604708 912 DD KAGFIHRQLVETRQITKNVARILHQRFNSEKDEEGNLIR—KVRI ITLKSALTSQFRKNY GIYKIREINDY 982

WP 010750235 914 DD KARFIQRQLVETRQITKHVAAILHQYFN-QTQELEK-EK—DIRIITLKSSLVSQFRQVF GIHKVREINHH 982

AII16583 950 LD KAGFIKRQLVETRQITKHVAQILDSRMNTKYDENDKLIR—EVKVITLKSKLVSDFRKDF QFYKVREINNY 1020

WP 029073316 928 KD KERFINRQIVETRQITKHVAQI I SNHYET TKWTVRADLSHAFRERY HIYKNRDINDF 987

WP 031589969 928 KD QERFINRQIVETRQITKHVAQIIDNHYEN TKWTVRADLSHQFRERY HIYKNRDINDF 987

KDA45870 903 KL KERFIERQLVETRQITKYVAQLLDQRLN—YDGNGVELD-eKIAIVTLKAQLASQFRSEF KLRKVRALNNL 972

WP 039099354 924 -D MKGFINRQLVETRQVIKLATNLLMEQYGED NIELITVKSGLTHQMRTEF DFPKNRNLNNH 990

AKP02966 926 KD KLGFIHRQLVQTSQMVKGVANILNSMYK NQGTTCIQ ARANLSTAFRKAL ELVKNRNINDF 999

WP 010991369 914 AD KARFIHRQLVETRQITKNVANILHQRFNYEKDDHGNTMK—QVRIVTLKSALVSQFRKQF QLYKVRDVNDY 984

WP 033838504 914 AD KARFIHRQLVETRQITKNVANILHQRFNYEKDDHGNTMK—QVRIVTLKSALVSQFRKQF QLYKVRDVNDY 984

EHN60060 917 AD KARFIHRQLVETRQITKNVANILHQRFNYEKDDHGNTMK—QVRIVTLKSALVSQFRKQF QLYKVRDVNDY 987

EFR89594 683 AD KARFIHRQLVETRQITKNVANILHQRFNYGKDDHGNTMK—QVRIVTLKSALVSQFRKQF QLYKVRGVNDY 753

WP 038409211 914 AD KANFIQRQLVETRQITKNVANILYQRFNCKQDENGNEVE—QVRIVTLKSTLVSQFRKQF QLYKVREVNDY 984

EFR95520 533 AD KANFIQRQLVETRQITKNVANILYQRFNCKQDENGNEVE—QVRIVTLKSTLVSQFRKQF QLYKVREVNDY 603

WP 003723650 914 AD KARFIHRQLVETRQITKNVANILYQRFNKETDNHGNTME—QVRIVTLKSALVSQFRKQF QLYKVREVNGY 984

WP 003727705 914 AD KARFIHRQLVETRQITKNVANILHQRFNKETDNHGNTME—QVRIVTLKSALVSQFRKQF QLYKVREVNDY 984

WP 003730785 914 AD KARFIHRQLVETRQITKNVANILHQRFNKETDNHGNTME—QVRIVTLKSALVSQFRKQF QLYKVREVNDY 984

WP 003733029 914 AD KARFIHRQLVETRQITKNVANILHQRFNYKTDGNKDTME—TVRIVTLKSALVSQFRKQF QFYKVREVNDY 984

WP 003739838 914 AD KATFIHRQLVETRQITKNVANILHQRFNNETDNHGNNME—QVRIVMLKSALVSQFRKQF QLYKVREVNDY 984

WP 014601172 914 AD KARFIHRQLVETRQITKNVANILHQRFNNETDNHGNTME- -QVRIVTLKSALVSQFRKQF QLYKVREVNDY 9En

WP 023548323 914 AD KARFIHRQLVETRQITKNVANILHQRFNYKTDDNEDTME- -PVRIVTLKSALVSQFRKQF QLYKVREVNDY 9En

WP 031665337 914 AD KARFIHRQLVETRQITKNVANILHQRFNKETDNHGNTME- -QVRIVTLKSALVSQFRKQF QLYKVREVNDY 9E

WP 031669209 914 AD KARFIHRQLVETRQITKNVANILHQRFNYKTDGNKDTME- -TVRIVTLKSALVSQFRKQF QFYKVREVNDY 9En

WP 033920898 914 AD KARFIHRQLVETRQITKNVANILHQRFNYKTDDNEDTME- -PVRIVTLKSALVSQFRKQF QLYKVREVNDY 9En

AKI42028 917 AD KARFIHRQLVETRQITKNVANILHQRFNNETDNHGNTME- -QVRIVTLKSALVSQFRKQF QLYKVREVNDY 9E 37

AKI50529 917 AD KARFIHRQLVETRQITKNVANILHQRFNYKTDDNEDTME- -PVRIVTLKSALVSQFRKQF QLYKVREVNDY 9E 37

EFR83390 362 AD KARFIHRQLVETRQITKNVANILHQRFNNETDNHGNTME- -QVRIVTLKSALVSQFRKQF QLYKVREVNDY 432

WP 046323366 914 AD KARFIHRQLVETRQITKNVANILHQRFNCKKDESGNVIE- -QVRIVTLKAALVSQFRKQF QLYKVREVNDY 9E 34

AKE81011 927 LD KAGFIKRQLVETRQITKHVAQILDSRMNTKYDENDKLIR- -EVKVITLKSKLVSDFRKDF QFYKVREINNY 997

CU082355 921 RD EERFINRQLVETRQITKNVTQIIEDHYST TKVAAIRANLSHEFRVKN HIYKNRDINDY 9E 30

WP 033162887 923 KD KERFINRQLVETRQI IKNVAVI INDHYTN TNIVTVRAELSHQFRERY KIYKNRDINDF 9E 32

AGZ 01981 944 LD KAGFIKRQLVETRQITKHVAQILDSRMNTKYDENDKLIR- -EVKVITLKSKLVSDFRKDF QFYKVREINNY 1014

AKA60242 911 LD KAGFIKRQLVETRQITKHVAQILDSRMNTKYDENDKLIR- -EVKVITLKSKLVSDFRKDF QFYKVREINNY 9E 31

AKS40380 911 LD KAGFIKRQLVETRQITKHVAQILDSRMNTKYDENDKLIR- -EVKVITLKSKLVSDFRKDF QFYKVREINNY 9E 31

4UN5 B 915 LD KAGFIKRQLVETRQITKHVAQILDSRMNTKYDENDKLIR- -EVKVITLKSKLVSDFRKDF QFYKVREINNY 9E 35

WP 010922251 982 HHAHDAYLNAWGTALIKKYPKL-ESEFVYGDYKVYDV s—-EQEi--GK -F- 1051

WP ^"039695303 9 92 HHAHDAYLNAWGTALLKKYPKL ASEFVYGEYKKYDI s— -SD -YfFYSNLM- 1058

WP ^"045635197 9 84 HHAHDAYLNAWAKAILKKYPKL EPEFVYGEYQKYDL SkdpKEV— -EK ATEKY- -F- FYSNLL- -NFFKEEVH 1055

5AXW A 7 03 HHAEDALI 1aNADFIFKEWKKLDK Nq-mFE -EK ETEQEykEi FITPHQiKHIKDFKD 771

WP 009880683 6 66 HHAHDAYLNAWGTALIKKYPKL ESEFVYGDYKVYDI S— -EQEi- -GK ATAKY- -F- FYSNIM- -NFFKTEIT 735

WP ^"010922251 9 82 HHAHDAYLNAWGTALIKKYPKL ESEFVYGDYKVYDV S— -EQEi- -GK ATAKY- -F- FYSNIM- -NFFKTEIT 1051

WP ^"011054416 9 82 HHAHDAYLNAWGTALIKKYPKL ESEFVYGDYKVYDV S— -EQEi- -GK ATAKY- -F- FYSNIM- -NFFKTEIT 1051

WP ^"011284745 9 82 HHAHDAYLNAWGTALIKKYPKL ESEFVYGDYKVYDV S— -EQEi- -GK ATAKY- -F- FYSNIM- -NFFKTEIT 1051

WP ^"011285506 9 82 HHAHDAYLNAWGTALIKKYPKL ESEFVYGDYKVYDV S— -EQEi- -GK ATAKY- -F- FYSNIM- -NFFKTEIT 1051

WP ^"011527619 9 82 HHAHDAYLNAWGTALIKKYPKL ESEFVYGDYKVYDV S— -EQEi- -GK ATAKY- -F- FYSNIM- -NFFKTEIT 1051

WP ^"012560673 9 82 HHAHDAYLNAWGTALIKKYPKL ESEFVYGDYKVYDI S— -EQEi- -GK ATAKY- -F- FYSNIM- -NFFKTEIT 1051

WP ^"014407541 9 81 HHAHDAYLNAWGTALIKKYPKL ESEFVYGDYKVYDV S— -EQEi- -GK ATAKY- -F- FYSNIM- -NFFKTEIT 1050

WP ^"020905136 9 82 HHAHDAYLNAWGTALIKKYPKL ESEFVYGDYKVYDV S— -EQEi- -GK ATAKY- -F- FYSNIM- -NFFKTEIT 1051

WP ^"023080005 9 81 HHAHDAYLNAWGTALIKKYPKL ESEFVYGDYKVYDV S— -EQEi- -GK ATAKY- -F- FYSNIM- -NFFKTEIT 1050

WP ^"023610282 9 81 HHAHDAYLNAWGTALIKKYPKL ESEFVYGDYKVYDV S— -EQEi- -GK ATAKY- -F- FYSNIM- -NFFKTEIT 1050

WP ^"030125963 9 82 HHAHDAYLNAWGTALIKKYPKL ESEFVYGDYKVYDV S— -EQEi- -GK ATAKY- -F- FYSNIM- -NFFKTEIT 1051

WP ^"030126706 9 82 HHAHDAYLNAWGTALIKKYPKL ESEFVYGDYKVYDV S— -EQEi- -GK ATAKY- -F- FYSNIM- -NFFKTEIT 1051

WP ^"031488318 9 82 HHAHDAYLNAWGTALIKKYPKL ESEFVYGDYKVYDV S— -EQEi- -GK ATAKY- -F- FYSNIM- -NFFKTEIT 1051

WP ^"032460140 9 82 HHAHDAYLNAWGTALIKKYPKL ESEFVYGDYKVYDI S— -EQEi- -GK ATAKY- -F- FYSNIM- -NFFKTEIT 1051

WP ^"032461047 9 82 HHAHDAYLNAWGTALIKKYPKL ESEFVYGDYKVYDI S— -EQEi- -GK ATAKY- -F- FYSNIM- -NFFKTEIT 1051

WP ^"032462016 9 82 HHAHDAYLNAWGTALIKKYPKL ESEFVYGDYKVYDV S— -EQEi- -GK ATAKY- -F- FYSNIM- -NFFKTEIT 1051

WP ^"032462936 9 82 HHAHDAYLNAWGTALIKKYPKL ESEFVYGDYKVYDV S— -EQEi- -GK ATAKY- -F- FYSNIM- -NFFKTEIT 1051

WP ^"032464890 9 82 HHAHDAYLNAWGTALIKKYPKL ESEFVYGDYKVYDV S— -EQEi- -GK ATAKY- -F- FYSNIM- -NFFKTEIT 1051

WP ^"033888930 8 07 HHAHDAYLNAWGTALIKKYPKL ESEFVYGDYKVYDV S— -EQEi- -GK ATAKY- -F- FYSNIM- -NFFKTEIT 876

WP ^"038431314 9 82 HHAHDAYLNAWGTALIKKYPKL ESEFVYGDYKVYDV S— -EQEi- -GK ATAKY- -F- FYSNIM- -NFFKTEIT 1051

WP ^"038432938 9 81 HHAHDAYLNAWGTALIKKYPKL ESEFVYGDYKVYDV S— -EQEi- -GK ATAKY- -F- FYSNIM- -NFFKTEIT 1050

WP ^"038434062 9 82 HHAHDAYLNAWGTALIKKYPKL ESEFVYGDYKVYDV S— -EQEi- -GK ATAKY- -F- FYSNIM- -NFFKTEIT 1051

BAQ51233 8 93 HHAHDAYLNAWGTALIKKYPKL ESEFVYGDYKVYDV s— -EQEi- -GK ATAKY- -F- FYSNIM- -NFFKTEIT 962

KGE60162 1 57 HHAHDAYLNAWGTALIKKYPKL ESEFVYGDYKVYDV s— -EQEi- -GK ATAKY- -F- FYSNIM- -NFFKTEIT 226

KGE60856

WP 002989955 9 82 HHAHDAYLNAWGTALIKKYPKL- ESEFVYGDYKVYDV s— -EQEi- -GK ATAKY- -F- FYSNIM- -NFFKTEIT 1051

WP ^"003030002 9 81 HHAHDAYLNAWGNALLLKYPQL- EPEFVYGEYPKYN- s— -YR sRK SATEK- -F1FYSNIL- -RFFKKE— 1041

WP ^"003065552 9 92 HHAHDAYLNAWGTALLKKYPKL- ASEFVYGEYKKYDI s— -SD KATAK- -YfFYSNLM- -NFFKRVIR 1058

WP ^"001040076 9 87 HHAHDAYLNAWAKAILTKYPQL- EPEFVYGDYPKYN- s— -YKT— -RK ATEKL- -F- FYSNIM- -NFFKTKVT 1049

WP ^"001040078 9 87 HHAHDAYLNAWAKAILTKYPQL- EPEFVYGLYRRKK- L— -SKI— -VR ATRKM- -F- FYSNLM- -NMFKRWR 1057

WP ^"001040080 9 87 HHAHDAYLNAWAKAILTKYPQL- EPEFVYGDYPKYN- S— -YKT— -RK ATEKL- -F- FYSNIM- -NFFKTKVT 1049

WP ^"001040081 9 87 HHAHDAYLNAWAKAILTKYPQL- EPEFVYGDYPKYN- S— -YKT— -RK ATEKL- -F- FYSNIM- -NFFKTKVT 1049

WP ^"001040083 9 87 HHAHDAYLNAWAKAILTKYPQL- EPEFVYGDYPKYN- s— -YKT— -RK ATEKL- -F- FYSNIM- -NFFKTKVT 1049

WP ^"001040085 9 87 HHAHDAYLNAWAKAILTKYPQL- EPEFVYGDYPKYN- s— -YKT— -RK ATEKL- -F- FYSNIM- -NFFKTKVT 1049

WP_001040087 987 HHAHDAYLNAWAKAILTKYPQL EPEFVYGDYPKYN- s---YKT---RK ATEKL--F- FYSNIM--NFFKTKVT 1049

WP_001040088 9 87 HHAHDAYLNAWAKAILTKYPQL EPEFVYGDYPKYN- s- - -YKT- - -RK ATEKL- -F- FYSNIM- -NFFKTKVT 1049

WP_001040089 9 87 HHAHDAYLNAWAKAILTKYPQL EPEFVYGDYPKYN- s- - -YKT- - -RK ATEKL- -F- FYSNIM- -NFFKTKVT 1049

WP_001040090 9 87 HHAHDAYLNAWAKAILTKYPQL EPEFVYGDYPKYN- s- - -YKT- - -RK ATEKL- -F- FYSNIM- -NFFKTKVT 1049

WP_001040091 9 87 HHAHDAYLNAWAKAILTKYPQL EPEFVYGDYPKYN- s- - -YKT- - -RK ATEKL- -F- FYSNIM- -NFFKTKVT 1049

WP_001040092 9 87 HHAHDAYLNAWAKAILTKYPQL EPEFVYGDYPKYN- s- - -YKT- - -RK ATEKL- -F- FYSNIM- -NFFKTKVT 1049

WP_001040094 9 87 HHAHDAYLNAWAKAILTKYPQL EPEFVYGDYPKYN- s- - -YKT- - -RK ATEKL- -F- FYSNIM- -NFFKTKVT 1049

WP_001040095 9 87 HHAHDAYLNAWAKAILTKYPQL EPEFVYGDYPKYN- s- - -YKT- - -RK ATEKL- -F- FYSNIM- -NFFKTKVT 1049

WP_001040096 9 87 HHAHDAYLNAWAKAILTKYPQL EPEFVYGDYPKYN- s- - -YKT- - -RK ATEKL- -F- FYSNIM- -NFFKTKVT 1049

WP_001040097 9 87 HHAHDAYLNAWAKAILTKYPQL EPEFVYGDYPKYN- s- - -YKT- - -RK ATEKL- -F- FYSNIM- -NFFKTKVT 1049

WP_001040098 9 87 HHAHDAYLNAWAKAILTKYPQL EPEFVYGDYPKYN- s- - -YKT- - -RK ATEKL- -F- FYSNIM- -NFFKTKVT 1049

WP_001040099 9 87 HHAHDAYLNAWAKAILTKYPQL EPEFVYGDYPKYN- s- - -YKT- - -RK ATEKL- -F- FYSNIM- -NFFKTKVT 1049

WP_001040100 9 87 HHAHDAYLNAWAKAILTKYPQL EPEFVYGDYPKYN- s- - -YKT- - -RK ATEKL- -F- FYSNIM- -NFFKTKVT 1049

WP_001040104 9 87 HHAHDAYLNAWAKAILTKYPQL EPEFVYGDYPKYN- s- - -YKT- - -RK ATEKL- -F- FYSNIM- -NFFKTKVT 1049

WP_001040105 9 87 HHAHDAYLNAWAKAILTKYPQL EPEFVYGDYPKYN- s- - -YKT- - -RK ATEKL- -F- FYSNIM- -NFFKTKVT 1049

WP_001040106 9 87 HHAHDAYLNAWAKAILTKYPQL EPEFVYGDYPKYN- s- - -YKT- - -RK ATEKL- -F- FYSNIM- -NFFKTKVT 1049

WP_001040107 9 87 HHAHDAYLNAWAKAILTKYPQL EPEFVYGDYPKYN- s- - -YKT- - -RK ATEKL- -F- FYSNIM- -NFFKTKVT 1049

WP_001040108 9 87 HHAHDAYLNAWAKAILTKYPQL EREFVYGDYPKYN- s- - -YKT- - -RK ATEKL- -F- FYSNIM- -NFFKTKVT 1049

WP_001040109 9 87 HHAHDAYLNAWAKAILTKYPQL EPEFVYGDYPKYN- s- - -YKT- - -RK ATEKL- -F- FYSNIM- -NFFKTKVT 1049

WP_001040110 9 87 HHAHDAYLNAWAKAILTKYPQL EPEFVYGDYPKYN- s- - -YKT- - -RK ATEKL- -F- FYSNIM- -NFFKTKVT 1049

WP_015058523 9 87 HHAHDAYLNAWAKAILTKYPQL EPEFVYGDYPKYN- s- - -YKT- - -RK ATEKL- -F- FYSNIM- -NFFKTKVT 1049

WP_017643650 9 87 HHAHDAYLNAWAKAILTKYPQL EPEFVYGDYPKYN- s- - -YKT- - -RK ATEKL- -F- FYSNIM- -NFFKTKVT 1049

WP_017647151 9 87 HHAHDAYLNAWAKAILTKYPQL EPEFVYGDYPKYN- s- - -YKT- - -RK ATEKL- -F- FYSNIM- -NFFKTKVT 1049

WP_017648376 9 87 HHAHDAYLNAWAKAILTKYPQL EPEFVYGDYPKYN- s- - -YKT- - -RK ATEKL- -F- FYSNIM- -NFFKTKVT 1049

WP_017649527 9 87 HHAHDAYLNAWAKAILTKYPQL EPEFVYGDYPKYN- s- - -YKT- - -RK ATEKL- -F- FYSNIM- -NFFKTKVT 1049

WP_017771611 9 87 HHAHDAYLNAWAKAILTKYPQL EPEFVYGDYPKYN- s- - -YKT- - -RK ATEKL- -F- FYSNIM- -NFFKTKVT 1049

WP_017771984 9 87 HHAHDAYLNAWAKAILTKYPQL EPEFVYGDYPKYN- s- - -YKT- - -RK ATEKL- -F- FYSNIM- -NFFKTKVT 1049

CFQ25032 9 87 HHAHDAYLNAWAKAILTKYPQL EPEFVYGDYPKYN- s- - -YKT- - -RK ATEKL- -F- FYSNIM- -NFFKTKVT 1049

CFV16040 9 87 HHAHDAYLNAWAKAILTKYPQL EPEFVYGDYPKYN- s- - -YKT- - -RK ATEKL- -F- FYSNIM- -NFFKTKVT 1049

KLJ37842 9 87 HHAHDAYLNAWAKAILTKYPQL EPEFVYGDYPKYN- s- - -YKT- - -RK ATEKL- -F- FYSNIM- -NFFKTKVT 1049

KLJ72361 9 87 HHAHDAYLNAWAKAILTKYPQL EPEFVYGDYPKYN- s- - -YKT- - -RK ATEKL- -F- FYSNIM- -NFFKTKVT 1049

KLL20707 1 001 HHAHDAYLNAWAKAILTKYPQL EPEFVYGDYPKYN- s- - -YKT- - -RK ATEKL- -F- FYSNIM- -NFFKTKVT 1063

KLL42645 9 87 HHAHDAYLNAWAKAILTKYPQL EPEFVYGDYPKYN- s- - -YKT- - -RK ATEKL- -F- FYSNIM- -NFFKTKVT 1049

WP_047207273 9 87 HHAHDAYLNAWAKAILTKYPQL EPEFVYGDYPKYN- s- - -YKT- - -RK ATEKL- -F- FYSNIM- -NFFKTKVT 1049

WP_047209694 9 87 HHAHDAYLNAWAKAILTKYPQL EPEFVYGDYPKYN- s- - -YKT- - -RK ATEKL- -F- FYSNIM- -NFFKTKVT 1049

WP_050198062 9 87 HHAHDAYLNAWAKAILTKYPQL EPEFVYGDYPKYN- s- - -YKT- - -RK ATEKL- -F- FYSNIM- -NFFKTKVT 1049

WP_050201642 9 87 HHAHDAYLNAWAKAILTKYPQL EPEFVYGDYPKYN- s- - -YKT- - -RK ATEKL- -F- FYSNIM- -NFFKTKVT 1049

WP_050204027 9 87 HHAHDAYLNAWAKAILTKYPQL EPEFVYGDYPKYN- s- - -YKT- - -RK ATEKL- -F- FYSNIM- -NFFKTKVT 1049

WP 050881965 9 87 HHAHDAYLNAWAKAILTKYPQL EPEFVYGDYPKYN- s- - -YKT- - -RK ATEKL- -F- FYSNIM- -NFFKTKVT 1049

WP 050886065 987 HHAHDAYLNAWAKAILTKYPQL--EPEFVYGDYPKYN- s-—YKT—-RK ATEKL--F-FYSNIM--NFFKTKVT 1049

AHN30376 9 87 HHAHDAYLNAWAKAILTKYPQL- -EPEFVYGDYPKYN- s- —YKT— -RK ATEKL- -F-FYSNIM- -NFFKTKVT 1049

EA078426 9 87 HHAHDAYLNAWAKAILTKYPQL- -EPEFVYGDYPKYN- s- —YKT— -RK ATEKL- -F-FYSNIM- -NFFKTKVT 1049

CCW42055 9 87 HHAHDAYLNAWAKAILTKYPQL- -EPEFVYGDYPKYN- s- —YKT— -RK ATEKL- -F-FYSNIM- -NFFKTKVT 1049

WP 0030415 02 9 81 HHAHDAYLNAVIGTALLKKYPKL- -ASEFVYGEFKKYDV s- —DK elG KATAK- -YfFYSNLM- -NFFKKEVK 1050

WP 0375937 52 9 82 HHAHDAYLNAWGNALLLKYPQL- -EPEFVYGEYPKYN- s- —YR sRK SATEK- -F1FYSNIL- -RFFKKE— 1042

WP 0495166 84 9 82 HHAHDAYLNAWGNALLLKYPQL- -EPEFVYGEYPKYN- s- —YR sRK SATEK- -F1FYSNIL- -RFFKKE— 1042

GAD46167 9 81 HHAHDAYLNAWGNALLLKYPQL- -EPEFVYGEYPKYN- s- —YR sRK SATEK- -F1FYSNIL- -RFFKKE— 1041

WP 0183634 70 9 90 HHAHDAYLNAWGTALLKKYPKL- -APEFVYGEYKKYDV s- —SDDhseMG KATAK- -YfFYSNLM- -NFFKRVIR 1062

WP 0030438 19 9 91 HHAHDAYLNAWGTALIKKYPKL- -ESEFVYGDYKVYDV s- —EQEi- -GK ATAKR- -F-FYSNIM- -NFFKTEVK 1060

WP 0062696 58 9 81 HHAHDAYLNAWGNALLLKYPQL- -EPEFVYGEYPKYN- s- —YR sRK SATEK- -F1FYSNIL- -RFFKKE— 1041

WP 0488008 89 9 81 HHAHDAYLNAWGTALLKKYPKL- -TSEFVYGEYKKYDV s- —DND—elG KATAK- -YfFYSNLM- -NFFKTEVK 1051

WP 0127671 06 9 81 HHAHDAYLNAWGTALIKKYTKL- -ESEFVYGDYKVYDV s- —EQEi- -GK ATAKR- -F-FYSNIM- -NFFKTEIT 1050

WP 0146123 33 9 81 HHAHDAYLNAWGTALIKKYPKL- -ESEFVYGDYKVYDV s- —EQEi- -GK ATAKR- -F-FYSNIM- -NFFKTEIT 1050

WP 0150170 95 9 81 HHAHDAYLNAWGTALIKKYPKL- -ESEFVYGDYKVYDV s- —EQEi- -GK ATAKR- -F-FYSNIM- -NFFKTEIT 1050

WP 0150576 49 9 81 HHAHDAYLNAWGTALIKKYPKL- -ESEFVYGDYKVYDV s- —EQEi- -GK ATAKR- -F-FYSNIM- -NFFKTEIT 1050

WP 0483272 15 9 81 HHAHDAYLNAWGTALIKKYPKL- -ESEFVYGDYKVYDV s- —EQEi- -GK ATAKR- -F-FYSNIM- -NFFKTEIT 1050

WP 0495193 24 9 81 HHAHDAYLNAWGTALIKKYPKL- -ESEFVYGDYKVYDV s- —EQEi- -GK ATAKR- -F-FYSNIM- -NFFKTEIT 1050

WP 0125159 31 9 81 HHAHDAYLNAWAKAILGKYPQL- -APEFVYGDYPKYN- s- —FKEr- -QK ATQKM- -L-FYSNIL- -KFFKDQES 1043

WP 0213209 64 9 81 HHAHDAYLNAWAKAILGKYPQL- -APEFVYGDYPKYN- s- —FKEr- -QK ATQKT- -L-FYSNIL- -KFFKDQES 1043

WP 0375817 60 9 81 HHAHDAYLNAWAKAILGKYPQL- -APEFVYGDYPKYN- s- —FKEr- -QK ATQKT- -L-FYSNIL- -KFFKDQES 1043

WP 0042324 81 9 89 HHAHDAYLNAWGTALLKKYPKL- -APEFVYGEYKKYDV s- —SDNhseLG KATAK- -YfFYSNLM- -NFFKTEVK 1061

WP 0098545 40 9 90 HHAHDAYLNAWGTALLKKYPKL- -ASEFVYGEYKKYDI s- —SD KATAK- -YfFYSNLM- -NFFKTKVK 1056

WP 0129621 74 9 90 HHAHDAYLNAWGTALLKKYPKL- -APEFVYGEYKKYDI s- —GD KATAK- -YfFYSNLM- -NFFKRVIR 1056

WP 0396953 03 9 92 HHAHDAYLNAWGTALLKKYPKL- -ASEFVYGEYKKYDI s- —SD KATAK- -YfFYSNLM- -NFFKTKVK 1058

WP 0143349 83 9 89 HHAHDAYLNAWGTALLKKYPKL- -TPEFVYGEYKKYDV s- —SDDyseMG KATAK- -YfFYSNLM- -NFFKTEVK 1061

WP 0030992 69 9 82 HHAQDAYLNAWGTALLKKYPKL- -EAEFVYGDYKHYDL P- —DSS1- -GK ATTRM- -F-FYSNLM- -NFFKKEIK 1051

AHY15608 9 82 HHAQDAYLNAWGTALLKKYPKL- -EAEFVYGDYKHYDL P- —DSS1- -GK ATTRM- -F-FYSNLM- -NFFKKEIK 1051

AHY17476 9 82 HHAQDAYLNAWGTALLKKYPKL- -EAEFVYGDYKHYDL P- —DSS1- -GK ATTRM- -F-FYSNLM- -NFFKKEIK 1051

ESR09100

AGM98575 9 82 HHAQDAYLNAWGTALLKKYPKL- -EAEFVYGDYKHYDL P- —DSS1- -GK ATTRM- -F-FYSNLM- -NFFKKEIK 1051

ALF27331 9 82 HHAHDAYLNAVIGKALLGVYPQL- -EPEFVYGDYPHFH- G- —HK eNK ATAKK- -F-FYSNIM- -NFFKKD— 1041

WP 0183724 92 9 95 HHAHDAYLNAWAQALLKVYPKF- -ERELVYGSYVKESI — —FS -RK ATERM- —rMYNNIL- -KFISKD— 1055

WP 0456180 28 9 85 HHAHDPYLNAWAKAILKKYPKL- -EPEFVYGDYQKYDL TkdpKEV— -EK ATEKY- -F-FYSNLL- -NFFKEEVH 1056

WP 0456351 97 9 84 HHAHDAYLNAWAKAILKKYPKL- -EPEFVYGEYQKYDL SkdpKEV— -EK ATEKY- -F-FYSNLL- -NFFKEEVH 1055

WP 0022635 49 9 82 HHAHDAYLNAVIGKALLGVYPQL- -EPEFVYGDYPHFH- G- —HK eNK ATAKK- -F-FYSNIM- -NFFKKD— 1041

WP 0022638 87 9 82 HHAHDAYLNAVIGKALLGVYPQL- -EPEFVYGDYPHFH- G- —HK eNK ATAKK- -F-FYSNIM- -NFFKKD— 1041

WP 0022649 20 9 82 HHAHDAYLNAVIGKALLGVYPQL- -EPEFVYGDYPHFH- G- —HK eNK ATAKK- -F-FYSNIM- -NFFKKD— 1041

WP 0022690 43 9 82 HHAHDAYLNAVIGKALLGVYPQL- -EPEFVYGDYPHFH- G- —HK eNK ATAKK- -F-FYSNIM- -NFFKKD— 1041

WP 002269448 9E32 HHAHDAYLNAVIGKALLGVYPQL EPEFVYGDYPHFH G—-HK—-eNK ATAKK--F- FYSNIM--NFFKKD— 1041

WP ^"002271977 9E 32 HHAHDAYLNAVIGKALLGVYPQL EPEFVYGDYPHFH G— -HK— -eNK ATAKK- -F- FYSNIM- -NFFKKD— 1041

WP ^"002272766 9E 32 HHAHDAYLNAVIGKALLGVYPQL EPEFVYGDYPHFH G— -HE— -eNK ATAKK- -F- FYSNIM- -NFFKKD— 1041

WP ^"002273241 9E 32 HHAHDAYLNAVIGKALLGVYPQL EPEFVYGDYPHFH G— -HK— -eNK ATAKK- -F- FYSNIM- -NFFKKD— 1041

WP ^"002275430 9E 32 HHAHDAYLNAVIGKALLGVYPQL EPEFVYGDYPHFH G— -HE— -eNK ATAKK- -F- FYSNIM- -NFFKKD— 1041

WP ^"002276448 9E 32 HHAHDAYLNAVIGKALLGVYPQL EPEFVYGDYPHFH G— -HK— -eNK ATAKK- -F- FYSNIM- -NFFKKD— 1041

WP ^"002277050 9E 34 HHAHDAYLNAVWKALLVKYPKL EPEFVYGEYPKYN S— -YR— -eRK ATQKM- -F- FYSNIM- -NMFKSKVK 1046

WP ^"002277364 9E 32 HHAHDAYLNAVIGKALLGVYPQL EPEFVYGDYPHFH G— -HK— -eNK ATAKK- -F- FYSNIM- -NFFKKD— 1041

WP ^"002279025 9E 32 HHAHDAYLNAVIGKALLGVYPQL EPEFVYGDYPHFH G— -HE— -eNK ATAKK- -F- FYSNIM- -NFFKKD— 1041

WP ^"002279859 9E 32 HHAHDAYLNAVIGKALLGVYPQL EPEFVYGDYPHFH G— -HK— -eNK ATAKK- -F- FYSNIM- -NFFKKD— 1041

WP ^"002280230 9E 32 HHAHDAYLNAVIGKALLGVYPQL EPEFVYGDYPHFH G— -HK— -eNK ATAKK- -F- FYSNIM- -NFFKKD— 1041

WP ^"002281696 9E 32 HHAHDAYLNAVIGKALLGVYPQL EPEFVYGDYPHFH G— -HK— -eNK ATAKK- -F- FYSNIM- -NFFKKD— 1041

WP ^"002282247 9E 34 HHAHDAYLNAVWKALLVKYPKL EPEFVYGEYPKYN S— -YR— -eRK ATQKM- -F- FYSNIM- -NMFKSKVK 1046

WP ^"002282906 9E 32 HHAHDAYLNAVIGKALLGVYPQL EPEFVYGDYPHFH G— -HK— -eNK ATAKK- -F- FYSNIM- -NFFKKD— 1041

WP ^"002283846 9E 32 HHAHDAYLNAVIGKALLGVYPQL EPEFVYGDYPHFH G— -HK— -eNK ATAKK- -F- FYSNIM- -NFFKKD— 1041

WP ^"002287255 9E 32 HHTHDAYLNAVIGKALLGVYPQL EPEFVYGDYPHFH G— -HK— -eNK ATAKK- -F- FYSNIM- -NFFKKD— 1041

WP ^"002288990 9E 32 HHAHDAYLNAVIGKALLGVYPQL EPEFVYGDYPHFH G— -HK— -eNK ATAKK- -F- FYSNIM- -NFFKKD— 1041

WP ^"002289641 9E 32 HHAHDAYLNAVIGKALLGVYPQL EPEFVYGDYPHFH G— -HK— -eNK ATAKK- -F- FYSNIM- -NFFKKD— 1041

WP ^"002290427 9E 32 HHAHDAYLNAVIGKALLGVYPQL EPEFVYGDYPHFH G— -HK— -eNK ATAKK- -F- FYSNIM- -NFFKKD— 1041

WP ^"002295753 9E 32 HHAHDAYLNAVIGKALLGVYPQL EPEFVYGDYPHFH G— -HK— -eNK ATAKK- -F- FYSNIM- -NFFKKD— 1041

WP ^"002296423 9E 32 HHAHDAYLNAVIGKALLGVYPQL EPEFVYGDYPHFH G— -HK— -eNK ATAKK- -F- FYSNIM- -NFFKKD— 1041

WP ^"002304487 996 HHAHDAYLNAVIGKALLGVYPQL EPEFVYGDYPHFH G— -HK— -eNK ATAKK- -F- FYSNIM- -NFFKKG— 1055

WP ^"002305844 9E 32 HHAHDAYLNAVIGKALLGVYPQL EPEFVYGDYPHFH G— -HK— -eNK ATAKK- -F- FYSNIM- -NFFKKD— 1041

WP ^"002307203 9E 32 HHAHDAYLNAVIGKALLGVYPQL EPEFVYGDYPHFH G— -HK— -eNK ATAKK- -F- FYSNIM- -NFFKKD— 1041

WP ^"002310390 9E 32 HHAHDAYLNAVIGKALLGVYPQL EPEFVYGDYPHFH G— -HK— -eNK ATAKK- -F- FYSNIM- -NFFKKD— 1041

WP ^"002352408 9E 32 HHAHDAYLNAVIGKALLGVYPQL EPEFVYGDYPHFH G— -HK— -eNK ATAKK- -F- FYSNIM- -NFFKKD— 1041

WP ^"012997688 9E 32 HHAHDAYLNAVIGKALLGVYPQL EPEFVYGDYPHFH G— -HK— -eNK ATAKK- -F- FYSNIM- -NFFKKD— 1041

WP ^"014677909 9E 32 HHAHDAYLNAVIGKALLGVYPQL EPEFVYGDYPHFH G— -HK— -eNK ATAKK- -F- FYSNIM- -NFFKKD— 1041

WP ^"019312892 9E 32 HHAHDAYLNAVIGKALLGVYPQL EPEFVYGDYPHFH G— -HK— -eNK ATAKK- -F- FYSNIM- -NFFKKD— 1041

WP ^"019313659 9E 32 HHAHDAYLNAVIGKALLGVYPQL EPEFVYGDYPHFH G— -HK— -eNK ATAKK- -F- FYSNIM- -NFFKKD— 1041

WP ^"019314093 9E 32 HHAHDAYLNAVIGKALLGVYPQL EPEFVYGDYPHFH G— -HK— -eNK ATAKK- -F- FYSNIM- -NFFKKD— 1041

WP ^"019315370 9E 32 HHAHDAYLNAVIGKALLGVYPQL EPEFVYGDYPHFH G— -HE— -eNK ATAKK- -F- FYSNIM- -NFFKKD— 1041

WP ^"019803776 9E 32 HHAHDAYLNAVIGKALLGVYPQL EPEFVYGDYPHFH G— -HK— -eNK ATAKK- -F- FYSNIM- -NFFKKD— 1041

WP ^"019805234 9E 32 HHAHDAYLNAVIGKALLGVYPQL EPEFVYGDYPHFH G— -HK— -eNK ATAKK- -F- FYSNIM- -NFFKKD— 1041

WP ^"024783594 9E 32 HHAHDAYLNAVIGKALLGVYPQL EPEFVYGDYPHFH G— -HK— -eNK ATAKK- -F- FYSNIM- -NFFKKD— 1041

WP ^"024784288 9E 34 HHAHDAYLNAVWKALLVKYPKL EPEFVYGEYLKYN S— -YR— -eRK ATQKM- -F- FYSNIM- -NMFKSKVK 1046

WP ^"024784666 9E 32 HHAHDAYLNAVIGKALLGVYPQL EPEFVYGDYPHFH G— -HK— -eNK ATAKK- -F- FYSNIM- -NFFKKD— 1041

WP ^"024784894 9E 32 HHAHDAYLNAVIGKALLGVYPQL EPEFVYGDYPHFH G— -HK— -eNK ATAKK- -F- FYSNIM- -NFFKKD— 1041

WP ^"024786433 9E 34 HHAHDAYLNAVWKALLVKYPKL EPEFVYGEYPKYN S— -YR— -eRK ATQKM- -F- FYSNIM- -NMFKSKVK 1046

WP 049473442 9E32 HHAHDAYLNAVIGKALLGVYPQL--EPEFVYGDYPHFH- G HE eNK ATAKK--F-^■FYSNIM--NFFKKD— 1041

WP ^"04947 4547 9E 32 HHAHDAYLNAVIGKALLGVYPQL- -EPEFVYGDYPHFH- G HK eNK ATAKK- -F- FYSNIM- -NFFKKD— 1041

EMC03581 975 HHAHDAYLNAVIGKALLGVYPQL- -EPEFVYGDYPHFH- G HK eNK ATAKK- -F- FYSNIM- -NFFKKD— 1034

WP 00042 8612 9E 37 HHAHDAYLNAWAKAILKKYPKL- -EPEFVYGDYQKYDL SkdpKEI— -EK ATEKY- -F- FYSNLL- -NFFKEEVH 1058

WP ^"00042 8613 9 i 35 HHAHDAYLNAWAKAILKKYPKL- -EPEFVYGDYQKYDL SrnpKEV— -EK ATEKY- -F- FYSNLL- -NFFKEEVH 1056

WP ^"04952 3028 9 i 30 HHAHDAYLNAWAKAILKKYPKL- -EPEFVYGDYQKYDL TkdpKEI— -EK ATEKY- -F- FYSNLL- -NFFKDKVY 1051

WP ^"00310 7102 951 HHAHDAYLNAWGTALLKKYPKL- -EAEFVYGDYKHYDL S DTS1- -GK ATAKM- -F- FYSNIM- -NFFKKEVR 1020

WP ^"05427 9288 9 i 33 HHAHDAYLNAWGTALLKMYPKL- -ASEFVYGDYQKYDL S GKAs- -GH ATAKY- -F- FYSNLM- -NFFKSEVK 1052

WP ^"04953 1101 9 i 35 HHAHDAYLNAWAKAILKKYPKL- -EPEFVYGDYQKYDL SrdpKEI— -EK ATEKY- -F- FYSNLL- -NFFKEEVH 1056

WP ^"04953 8452 9 i 35 HHAHDAYLNAWAKAILKKYPKL- -EPEFVYGDYQKYDL SkdpKDI— -EK ATEKY- -F- FYSNLL- -NFFKEEVH 1056

WP ^"04954 9711 9 i 37 HHAHDAYLNAWAKAILKKYPKL- -EPEFVYGDYQKNDL SkdpKDI— -EK ATEKY- -F- FYSNLL- -NFFKEEVH 1058

WP ^"00789 6501 9 i 38 HHAHDAYLNAWGTALLKKYPKL- -EAEFVYGDYKHFDL S DPS1- -GK ATAKV- -F- FYSNIM- -NFFKEELS 1057

EFR44625 940 HHAHDAYLNAWGTALLKKYPKL- -EAEFVYGDYKHFDL S DPS1- -GK ATAKV- -F- FYSNIM- -NFFKEELS 1009

WP 00289 7477 9 i 34 HHAHDAYLNAWAKAILKKYPKL- -EPEFVYGDYQKYDL FkpsKEI— -EK ATEKY- -F- FYSNLL- -NFFKEEVL 1055

WP ^"00290 6454 9 i 34 HHAHDAYLNAWAKAILKKYPKL- -EPEFVYGDYQKYDL SkasNTI— -DK ATEKY- -F- FYSNLL- -NFFKEKVR 1055

WP ^"00972 9476 9 i 35 HHAHDAYLNAWAKAILKKYPKL- -EPEFVYGDYQKYDL SkdpKEI— -EK ATEKY- -F- FYSNLL- -NFFKEEVH 1056

CQR24647 9 i 34 HHAHDAYLNAWAKALLIRYPKL- -EPEFVYGEYPKYN- S YRE— -RK ATEKM- -F- FYSNIM- -NMFKTTIK 1046

WP 00006 6813 9 i 39 HHAHDAYLNAVLAKAILKKYPKL- -EPEFVYGDYQKYDL SrepKEV— -EK ATQKY- -F- FYSNLL- -NFFKEEVH 1060

WP ^"00975 4323 9 i 35 HHAHDAYLNAWAKAILKKYPKL- -EPEFVYGDYQKYDL SkdpKEV— -EK ATEKY- -F- FYSNLL- -NFFKEEVH 1056

WP ^"04467 4937 9 i 36 HHAHDAYLNAWATALLKKYPQL- -APEFVYGDYPKYN- S YKS— -RK ATEKV- -L- FYSNIM- -NFFRRVLV 1048

WP ^"04467 6715 9 i 38 HHAHDAYLNAWATALLKKYPQL- -APEFVYGDYPKYN- S YKS— -RK ATEKV- -L- FYSNIM- -NFFRRVLV 1050

WP ^"04468 0361 9 i 38 HHAHDAYLNAWATALLKKYPQL- -APEFVYGDYPKYN- S YKS— -RK ATEKV- -L- FYSNIM- -NFFRRVLV 1050

WP ^"04468 1799 9 i 36 HHAHDAYLNAWATALLKKYPQL- -APEFVYGDYPKYN- S YKS— -RK ATEKV- -L- FYSNIM- -NFFRRVLV 1048

WP ^"04953 3112 9 i 31 HHAHDAYLNAVIGTALLKKYPKL- -ASEFVYGEFKKYDV S DK elG KATAK- -YfFYSNLM- -NFFKKEVK 1050

WP ^"02909 0905 952 HHAQDAFLVAFLGTNITSNYPKI- -EMEYLFKGYQHYLN Ev- -GK AAKPKftF- IVENLS- 1007

WP ^"00650 6696 977 HHAHDAYIVALIGGFMRDRYPNMhDSKAVYSEYMKMFR NKNd- -QK g FVINSM- -NYPY-EV- 1038

AIT42264 9 i 32 HHAHDAYLNAWGTALIKKYPKL- -ESEFVYGDYKVYDV S EQEi- -GK ATAKY- -F- FYSNIM- -NFFKTEIT 1051

WP 03444 0723 9 i 31 HHAHDAYLNGVIALKLLELYPYM- -AKDLIYGKYSYHRK c JJl\ ATQAK- -Y- ^■KMSNII- -ERFSQDL- 1041

AKQ21048 9 i 32 HHAHDAYLNAWGTALIKKYPKL- -ESEFVYGDYKVYDV S EQEi- -GK ATAKY- -F- FYSNIM- -NFFKTEIT 1051

WP 00463 6532 9 i 31 HHGHDAYLNAWATTIMKVYPNL- -KPQFVYGQYKKTSM FKE— -EK ATARK- -H- FYSNIT- -KFFKKEKV 1042

WP ^"00236 4836 9 i 38 HHGQDAYLNCWATTLLKVYPNL- -APEFVYGEYPKFQT FKE— -NK ATAKA- -I- IYTNLL- -RFFTED— 1047

WP ^"01663 1044 939 HHGQDAYLNCWATTLLKVYPNL- -APEFVYGEYPKFQT FKE— -NK ATAKA- -I- IYTNLL- -RFFTED— 998

EMS75795 723 HHAHDAYLNGWAIALLKKYPKL- -EPEFVYGNYTKFNL AT eNK ATAKK- -E- FYSNIL- -RFFEKE— 782

WP 00237 3311 9 i 38 HHGQDAYLNCWATTLLKVYPNL- -APEFVYGEYPKFQA FKE— -NK ATAKT- -I- IYTNLM- -RFFTED— 1047

WP ^"00237 8009 9 i 38 HHGQDAYLNCWATTLLKVYPNL- -APEFVYGEYPKFQT FKE— -NK ATAKA- -I- IYTNLL- -RFFTED— 1047

WP ^"00240 7324 9 i 38 HHGQDAYLNCWATTLLKVYPNL- -APEFVYGEYPKFQT FKE— -NK ATAKA- -I- IYTNLL- -RFFTED— 1047

WP ^"00241 3717 9 i 38 HHGQDAYLNCWATTLLKVYPNL- -APEFVYGEYPKFQT FKE— -NK ATAKA- -I- IYTNLL- -RFFTED— 1047

WP ^"01077 5580 990 HHGQDAYLNCWATTLLKVYPNL- -APEFVYGEYPKFQA FKE— -NK ATAKA- -I- IYTNLL- -RFFTED— 1049

WP ^"01081 8269 9E 38 HHGQDAYLNCWATTLLKVYPNL- -APEFVYGEYPKFQT FKE— -NK ATAKA- -I- IYTNLL- -RFFTED— 1047

WP 010824395 988 HHGQDAYLNCWATTLLKVYPNL--APEFVYGEYPKFQT -FKE-—NK ATAKT--I- IYTNLM-^■RFFTED— 1047

WP 016622645 988 HHGQDAYLNCWATTLLKVYPNL- -APEFVYGEYPKFQT -FKE- —NK ATAKA- -I- IYTNLL- ^■RFFTED— 1047

WP 033624816 988 HHGQDAYLNCWATTLLKVYPNL- -APEFVYGEYPKFQA -FKE- —NK AMAKA- -I- IYTNLL- ^■RFFTED— 1047

WP 033625576 988 HHGQDAYLNCWATTLLKVYPNL- -APEFVYGEYPKFQA -FKE- —NK ATAKA- -I- IYTNLM- ^■RFFTEV— 1047

WP 033789179 988 HHGQDAYLNCWATTLLKVYPNL- -APEFVYGEYPKFQA -FKE- —NK ATAKA- -I- IYTNLL- ^■RFFTED— 1047

WP 002310644 989 HHAHDAYLNGWALALLKKYPQL- -APEFVYGEYLKFNA -HK— -aNK ATVKK- -E- FYSNIM- ^■KFFESD— 1048

WP 002312694 990 HHAHDAYLNGWALALLKKYPQL- -APEFVYGEYLKFNA -HK— -aNK ATVKK- -E- FYSNIM- ^■KFFESD— 1049

WP 002314015 990 HHAHDAYLNGWALALLKKYPQL- -APEFVYGEYLKFNA -HK— -aNK ATVKK- -E- FYSNIM- ^■KFFESD— 1049

WP 002320716 990 HHAHDAYLNGWALALLKKYPQL- -APEFVYGEYLKFNA -HK— -aNK ATVKK- -E- FYSNIM- ^■KFFESD— 1049

WP 002330729 989 HHAHDAYLNGWALALLKKYPQL- -APEFVYGEYLKFNA -HK— -aNK ATVKK- -E- FYSNIM- ^■KFFESD— 1048

WP 002335161 990 HHAHDAYLNGWALALLKKYPQL- -APEFVYGEYLKFNA -HK— -aNK ATVKK- -E- FYSNIM- ^■KFFESD— 1049

WP 002345439 990 HHAHDAYLNGWALALLKKYPQL- -APEFVYGEYLKFNA -HK— -aNK ATVKK- -E- FYSNIM- ^■KFFESD— 1049

WP 034867970 980 HHAHDAYLNGFIANVLLKRYPKL- -APEFVYGKYVKYSL -AR— -eNK ATAKK- -E- FYSNIL- ^■KFLESD— 1039

WP 047937432 990 HHAHDAYLNGVIALALLKKYPQL- -APEFVYGEYLKFNA -HK— -aNK ATVKK- -E- FYSNIM- ^■KFFESD— 1049

WP 010720994 980 HHAHDAYLNGFIANVLLKRYPKL- -APEFVYGKYVKYSL -AR— -eNK ATAKK- -E- FYSNIL- ^■KFLESD— 1039

WP 010737004 980 HHAHDAYLNGFIANVLLKRYPKL- -APEFVYGKYVKYSL -AR— -eNK ATAKK- -E- FYSNIL- ^■KFLESD— 1039

WP 034700478 980 HHAHDAYLNGFIANVLLKRYPKL- -APEFVYGKYVKYSL -AR— -eNK ATAKK- -E- FYSNIL- ^■KFLESD— 1039

WP 007209003 978 HHAHDAYLNAWALSLLRVYPQL- -KPEFVYGEYGKNS- -IHDq —NK ATIKK- —qFYSNIT- ^■RYFASK— 1037

WP 023519017 974 HHAHDAYLNGWAMTLLKKYPKL- -APEFVYGSYIKGDI -NQ— -iNK ATAKK- -E- FYSNIM- ^■KFFESE— 1033

WP 010770040 986 HHGHDAYLNGWANSLLRVYPQL- -QPEFVYGDYPKFNA -YKA- —NK ATAKK- -Q- LYTNIM- ^■KFFAED— 1045

WP 048604708 983 HHAHDAYLNGWATALLKIYPQL- -EPEFVYGEFHRFNA -FKE- —NK ATAKK- -Q- FYSNLM- ^■EFSKSD— 1042

WP 010750235 983 HHAHDAYLNAWALALLKKYPRL- -APEFVYGSFAKFHL -VK— -eNK ATAKK- -E- FYSNIL- ^■KFFEKE— 1042

AII16583 1021 HHAHDAYLNAWGTALIKKYPKL- -ESEFVYGDYKVYDV S— -EQEi —GK ATAKY- -F- FYSNIM- ^■NFFKTEIT 1090

WP 029073316 988 HHAHDAYIATILGTYIGHRFESL- -DAKYIYGEYQKIFR -NKNk —DK KDg FILNSM- ^■RNLYADK- 1052

WP 031589969 988 HHAHDAYIATILGTYIGHRFESL- -DAKYIYGEYKRIFR -QKNk —GK NDg FILNSM- ^■RNIYADK- 1052

KDA45870 973 HHAHDAYLNAWANLIMAKYPEL- -EPEFVYGKYRKTK- -FKG1 —GK ATAKN- —tLYANVL- ^■YFLKENEV 1034

WP 039099354 991 HHAFDAYLTAFVGLYLLKRYPKL- -KPYFVYGEYQKAS- -QQ-- —DK RN- -F- NFL- ^■NGLKKD— 1043

AKP02966 1000 HHAQDAYLASFLGTYRLRRFPTD- -EMLLMNGEYNKFYG —KE1ysKK -SRKN-gF- IISPLV- 1062

WP 010991369 985 HHAHDAYLNGWANTLLKVYPQL- -EPEFVYGDYHQFDW -FKA- —NK ATAKK- -Q- FYTNIM- ^■LFFAQK— 1044

WP 033838504 985 HHAHDAYLNGWANTLLKVYPQL- -EPEFVYGDYHQFDW -FKA- —NK ATAKK- -Q- FYTNIM- ^■LFFAQK— 1044

EHN60060 988 HHAHDAYLNGWANTLLKVYPQL- -EPEFVYGDYHQFDW -FKA- —NK ATAKK- -Q- FYTNIM- ^■LFFAQK— 1047

EFR89594 754 HHAHDAYLNGWANTLLKVYPQL- -EPEFVYGDYHQFDW -FKA- —NK ATAKK- -Q- FYTNIM- ^■LFFAQK— 813

WP 038409211 985 HHAHDAYLNGWANTLLKVYPQL- -EPEFVYGDYHQFDW -FKA- —NK ATAKK- -Q- FYTNIM- ^■RFFAKE— 1044

EFR95520 604 HHAHDAYLNGWANTLLKVYPQL- -EPEFVYGDYHQFDW -FKA- —NK ATAKK- -Q- FYTNIM- ^■RFFAKE— 663

WP 003723650 985 HHAHDAYLNGWANTLLKVYPQL- -EPEFVYGEYHQFDW -FKA- —NK ATAKK- -Q- FYTNIM- ^■LFFAQK— 1044

WP 003727705 985 HHAHDAYLNGWANTLLKVYPQL- -EPEFVYGEYHQFDW -FKA- —NK ATAKK- -Q- FYTNIM- ^■LFFAQK— 1044

WP 003730785 985 HHAHDAYLNGWANTLLKVYPQL- -EPEFVYGEYHQFDW -FKA- —NK ATAKK- -Q- FYTNIM- ^■LFFAQK— 1044

WP 003733029 985 HHAHDAYLNGWANTLLKVYPQL- -EPEFVYGEYHQFGW -FKA- —NK ATAKK- -Q- FYTNIM- ^■LFFAQK— 1044

WP 003739838 985 HHAHDAYLNGWANTLLKVYPQL- -EPEFVYGEYHQFDW -FKA- —NK ATAKK- -Q- FYTNIM- ^■LFFAQK— 1044

111

WP 014601172 985 HHAHDAYLNGWANTLLKVYPQL-EPEFVYGEYHQFDW FKA—-NK ATAKK--Q- FYTNIM-^■LFFGQK— 1044

WP 023548323 9 85 HHAHDAYLNGWANTLLKVYPQL-EPEFVYGEYHQFDW FKA— -NK ATAKK- -Q- FYTNIM- ^■LFFAQK— 1044

WP 031665337 9 85 HHAHDAYLNGWANTLLKVYPQL-EPEFVYGEYHQFDW FKA— -NK ATAKK- -Q- FYTNIM- ^■LFFAQK— 1044

WP 031669209 9 85 HHAHDAYLNGWANTLLKVYPQL-EPEFVYGEYHQFDW FKA— -NK ATAKK- -Q- FYTNIM- ^■LFFAQK— 1044

WP 033920898 9 85 HHAHDAYLNGWANTLLKVYPQL-EPEFVYGEYHQFDW FKA— -NK ATAKK- -Q- FYTNIM- ^■LFFAQK— 1044

AKI42028 9 88 HHAHDAYLNGWANTLLKVYPQL-EPEFVYGEYHQFDW FKA— -NK ATAKK- -Q- FYTNIM- ^■LFFGQK— 1047

AKI50529 9 88 HHAHDAYLNGWANTLLKVYPQL-EPEFVYGEYHQFDW FKA— -NK ATAKK- -Q- FYTNIM- ^■LFFAQK— 1047

EFR83390 4 33 HHAHDAYLNGWANTLLKVYPQL-EPEFVYGEYHQFDW FKA— -NK ATAKK- -Q- FYTNIM- ^■LFFAQK— 492

WP 046323366 9 85 HHAHDAYLNCWANTLLKVYPQL-EPEFVYGDYHQFDW FKA— -NK ATAKK- -Q- FYTNIM- ^■LFFAKK— 1044

AKE81011 9 98 HHAHDAYLNAWGTALIKKYPKL-ESEFVYGDYKVYDV EQEi- -GK ATAKY- -F- FYSNIM- ^■NFFKTEIT 1067

CU082355 9 81 HHAHDAYIVALIGGFMRDRYPNMhDSKAVYSEYMKMFR NKNd- -QK g FVINSM- ^■NYPY-EV- 1042

WP 033162887 9 83 HHAHDAYIACIVGQFMHQNFEHL-DAKIIYGQYK KNy- -KK NYg FILNSM- ^■NHLQSDI- 1042

AGZ 01981 1 015 HHAHDAYLNAWGTALIKKYPKL-ESEFVYGDYKVYDV EQEi- -GK ATAKY- -F- FYSNIM- ^■NFFKTEIT 1084

AKA60242 9 82 HHAHDAYLNAWGTALIKKYPKL-ESEFVYGDYKVYDV EQEi- -GK ATAKY- -F- FYSNIM- ^■NFFKTEIT 1051

AKS40380 9 82 HHAHDAYLNAWGTALIKKYPKL-ESEFVYGDYKVYDV EQEi- -GK ATAKY- -F- FYSNIM- ^■NFFKTEIT 1051

4UN5 B 9 86 HHAHDAYLNAWGTALIKKYPKL-ESEFVYGDYKVYDV EQEi- -GK ATAKY- -F- FYSNIM- ^■NFFKTEIT 1055

WP 010922251 1052 ^■GEIRKRPLIE TNGET- 1114

^"039695303 1059 T 1120

WP ^"045635197 1056 YAD- GTIVKRENIE Y-SKDtGE- IAWNKEKDFAIIKKVLS- -LPQVNIVKKREVQT GGFSK ESIL- ^■PKG- 1118

5AXW A 772 YKYsHRVDKKPNRE VNNLN- ^■GL- ^■—YDKDND—KLKKLINkSPEKLLMYHHDPQT —YQK KLIMeQYGd 852

009880683 736 LAN- 798

^"010922251 1052 LAN- 1114

^"011054416 1052 LAN- 1114

^"011284745 1052 LAN- 1114

^"011285506 1052 LAN- 1114

^"011527619 1052 LAN- 1114

^"012560673 1052 LAN- 1114

^"014407541 1051 LAN- 1113

^"020905136 1052 LAN- 1114

^"023080005 1051 LAN- 1113

^"023610282 1051 LAN- 1113

^"030125963 1052 LAN- 1114

^"030126706 1052 LAN- 1114

^"031488318 1052 LAN- 1114

^"032460140 1052 LAN- 1114

^"032461047 1052 LAN- 1114

^"032462016 1052 LAN- 1114

^"032462936 1052 LAN- 1114

^"032464890 1052 LAN- 1114

^"033888930 877 LAN- 939

^"038431314 1052 LAN- 1114

^"038432938 1051 LAN- 1113

^"038434062 1052 LAN- 1114

BAQ51233 963 LAN- 1025

227 LAN- 289

KGE60856 1 52

002989955 1052 LAN- 1114

^"003030002 1042 DIQ T 1093

WP ^"003065552 1059 YSN- GKVIVRPWE Y-SKD- ^■TEdlAWDKKSNFRTICKVLS- -YPQVNIVKKVETQT GGFSK ESIL- ^■PKG- 1121

WP ^"001040076 1050 LAD- GTVWKDDIE VNNDT- ^■GE- IVWDKKKHFATVRKVLS- -YPQVNIVKKTEIQT GGFSK ESIL- ^■AHG- 1112

WP ^"001040078 1058 LAD- GSIWRPVIE TGRYM- ^■GK- TAWDKKKHFATVRKVLS- -YPQVNIVKKTEIQT GGFSK ESIL- ^■AHG- 1120

WP ^"001040080 1050 LAD- ^■GTVWKDDIE VNNDT- ^■GE- IVWDKKKHFATVRKVLS- -YPQNNIVKKTEIQT GGFSK ESIL- ^■AHG- 1112

WP ^"001040081 1050 LAD- ^■GTVWKDDIE VNNDT- ^■GE- IVWDKKKHFATVRKVLS- -YPQNNIVKKTEIQT GGFSK ESIL- ^■AHG- 1112

WP ^"001040083 1050 LAD- ^■GTVWKDDIE VNNDT- ^■GE- IVWDKKKHFATVRKVLS- -YPQNNIVKKTEIQT GGFSK ESIL- ^■AHG- 1112

WP ^"001040085 1050 LAD- ^■GTVWKDDIE VNNDT- ^■GE- IVWDKKKHFATVRKVLS- -YPQNNIVKKTEIQT GGFSK ESIL- ^■AHG- 1112

WP 001040087 1050 LAD-^■GTVWKDDIE VNNDT-^■GE-^■IVWDKKKHFATVRKVLS^■-YPQNNIVKKTEIQT GGFSK ESIL--AHG- 1112

WP ^"001040088 1050 LAD- ^■GTVWKDDIE VNNDT- ^■GE- IVWDKKKHFATVRKVLS- -YPQNNIVKKTEIQT GGFSK ESIL- -AHG- 1112

WP ^"001040089 1050 LAD- ^■GTVWKDDIE VNNDT- ^■GE- IVWDKKKHFATVRKVLS- -YPQNNIVKKTEIQT GGFSK ESIL- -AHG- 1112

WP ^"001040090 1050 LAD- ^■GTVWKDDIE VNNDT- ^■GE- IVWDKKKHFATVRKVLS- -YPQNNIVKKTEIQT GGFSK ESIL- -AHG- 1112

WP ^"001040091 1050 LAD- ^■GTVWKDDIE VNNDT- ^■GE- IVWDKKKHFATVRKVLS- -YPQNNIVKKTEIQT GGFSK ESIL- -AHG- 1112

WP ^"001040092 1050 LAD- ^■ETWVKDDIE VNNET- ^■GE- IAWDKKKHFATVRKVLS- -YPQVNIVKKTEVQT GGFSK ESIL- -AHS- 1112

WP ^"001040094 1050 LAD- ^■GTVWKDDIE VNNDT- ^■GE- IVWDKKKHFATVRKVLS- -YPQVNIVKKTEIQT GGFSK ESIL- -AHG- 1112

WP ^"001040095 1050 LAD- ^■GTVWKDDIE VNNDT- ^■GE- IVWDKKKHFATVRKVLS- -YPQVNIVKKTEVQT GGFSK ESIL- -AHG- 1112

WP ^"001040096 1050 LAD- ^■GTVWKDDIE VNNDT- ^■GE- IVWDKKKHFATVRKVLS- -YPQVNIVKKTEVQT GGFSK ESIL- -AHG- 1112

WP ^"001040097 1050 LAD- ^■GTVWKDDIE VNNDT- ^■GE- IVWDKKKHFATVRKVLS- -YPQVNIVKKTEIQT GGFSK ESIL- -AHG- 1112

WP ^"001040098 1050 LAD- ^■GTVWKDDIE VNNDT- ^■GE- IVWDKKKHFATVRKVLS- -YPQVNIVKKTEIQT GGFSK ESIL- -AHG- 1112

WP ^"001040099 1050 LAD- ^■GTVWKDDIE VNNDT- ^■GE- IVWDKKKHFATVRKVLS- -YPQVNIVKKTEIQT GGFSK ESIL- -AHG- 1112

WP ^"001040100 1050 LAD- ^■GTVWKDDIE VNNDT- ^■GE- IVWDKKKHFATVRKVLS- -YPQVNIVKKTEIQT GGFSK ESIL- -AHG- 1112

WP ^"001040104 1050 LAD- ^■GTVWKDDIE VNNDT- ^■GE- IVWDKKKHFATVRKVLS- -YPQNNIVKKTEIQT GGFSK ESIL- -AHG- 1112

WP ^"001040105 1050 LAD- ^■GTVWKDDIE VNNDT- ^■GE- IVWDKKKHFATVRKVLS- -YPQNNIVKKTEIQT GGFSK ESIL- -AHG- 1112

WP ^"001040106 1050 LAD- ^■GTVWKDDIE VNNDT- ^■GE- IVWDKKKHFATVRKVLS- -YPQVNIVKKTEIQT GGFSK ESIL- -AHG- 1112

WP ^"001040107 1050 LAD- ^■GTVWKDDIE VNNDT- ^■GE- IVWDKKKHFATVRKVLS- -YPQVNIVKKTEIQT GGFSK ESIL- -AHG- 1112

WP ^"001040108 1050 LAD- ^■GTVWKDDIE VNNDT- ^■GE- IVWDKKKHFATVRKVLS- -YPQVNIVKKTEIQT GGFSK ESIL- -AHG- 1112

WP ^"001040109 1050 LAD- ^■GTVWKDDIE VNNDT- ^■GE- IVWDKKKHFATVRKVLS- -YPQVNIVKKTEIQT GGFSK ESIL- -AHG- 1112

WP ^"001040110 1050 LAD- ^■GTVWKDDIE VNNDT- ^■GE- IVWDKKKHFATVRKVLS- -YPQVNIVKKTEIQT GGFSK ESIL- -AHG- 1112

WP ^"015058523 1050 LAD- ^■ETWVKDDIE VNNET- ^■GE- IAWDKKKHFATVRKVLS- -YPQVNIVKKTEVQT GGFSK ESIL- -AHS- 1112

WP ^"017643650 1050 LAD- ^■GTVWKDDIE VNNDT- ^■GE- IVWDKKKHFATVRKVLS- -YPQVNIVKKTEIQT GGFSK ESIL- -AHG- 1112

WP ^"017647151 1050 LAD- ^■GTVWKDDIE VNNDT- ^■GE- IVWDKKKHFATVRKVLS- -YPQVNIVKKTEIQT GGFSK ESIL- -AHG- 1112

WP ^"017648376 1050 LAD- ^■GTVWKDDIE VNNDT- ^■GE- IVWDKKKHFATVRKVLS- -YPQVNIVKKTEIQT GGFSK ESIL- -AHG- 1112

WP ^"017649527 1050 LAD- ^■GTVWKDDIE VNNDT- ^■GE- IVWDKKKHFATVRKVLS- -YPQNNIVKKTEIQT GGFSK ESIL- -AHG- 1112

WP ^"017771611 1050 LAD- ^■GTVWKDDIE VNNDT- ^■GE- IVWDKKKHFATVRKVLS- -YPQVNIVKKTEIQT GGFSK ESIL- -AHG- 1112

WP ^"017771984 1050 LAD- ^■GTVWKDDIE VNNDT- ^■GE- IVWDKKKHFATVRKVLS- -YPQNNIVKKTEIQT GGFSK ESIL- -AHG- 1112

CFQ25032 1050 LAD- ^■GTVWKDDIE VNNDT- ^■GE- IVWDKKKHFATVRKVLS- -YPQNNIVKKTEIQT GGFSK ESIL- -AHG- 1112

CFV16040 1050 LAD- ^■GTVWKDDIE VNNDT- ^■GE- IVWDKKKHFATVRKVLS- -YPQNNIVKKTEIQT GGFSK ESIL- -AHG- 1112

KLJ37842 1050 LAD- ^■GTVWKDDIE VNNDT- ^■GE- IVWDKKKHFATVRKVLS- -YPQNNIVKKTEIQT GGFSK ESIL- -AHG- 1112

KLJ72361 1050 LAD- ^■GTVWKDDIE VNNDT- ^■GE- IVWDKKKHFATVRKVLS- -YPQNNIVKKTEIQT GGFSK ESIL- -AHG- 1112

KLL20707 1064 LAD- ^■GTVWKDDIE VNNDT- ^■GE- IVWDKKKHFATVRKVLS- -YPQNNIVKKTEIQT GGFSK ESIL- -AHG- 1126

KLL42645 1050 LAD- ^■GTVWKDDIE VNNDT- ^■GE- IVWDKKKHFATVRKVLS- -YPQVNIVKKTEIQT GGFSK ESIL- -AHG- 1112

WP 047207273 1050 LAD- ^■GTVWKDDIE VNNDT- ^■GE- IVWDKKKHFATVRKVLS- -YPQNNIVKKTEIQT GGFSK ESIL- -AHG- 1112

WP ^"047209694 1050 LAD- ^■GTVWKDDIE VNNDT- ^■GE- IVWDKKKHFATVRKVLS- -YPQVNIVKKTEIQT GGFSK ESIL- -AHG- 1112

WP ^"050198062 1050 LAD- ^■GTWIKDDIE VNNDT- ^■GE- IVWDKKKHFATVRKVLS- -YPQNNIVKKTEIQT GGFSK ESIL- -AHG- 1112

WP ^"050201642 1050 LAD- ^■GTVWKDDIE VNNDT- ^■GE- IVWDKKKHFATVRKVLS- -YPQNNIVKKTEIQT GGFSK ESIL- -AHG- 1112

WP ^"050204027 1050 LAD- ^■GTVWKDDIE VNNDT- ^■GE- IVWDKKKHFATVRKVLS- -YPQVNIVKKTEIQT GGFSK ESIL- -AHG- 1112

WP ^"050881965 1050 LAD- ^■GTVWKDDIE VNNDT- ^■GE- IVWDKKKHFATVRKVLS- -YPQNNIVKKTEIQT GGFSK ESIL- -AHG- 1112

WP_050886065 1050 LAD-GTVWKDDIE VNNDT-GE- IVWDKKKHFATVRKVLS--YPQNNIVKKTEIQT GGFSK ESIL--AHG- 1112

AHN30376 1050 LAD-ETVWKDDIE VNNET-GE- IAWDKKKHFATVRKVLS- -YPQVNIVKKTEVQT GGFSK ESIL- -AHS- 1112

EA078426 1050 LAD-GTVWKDDIE VNNDT-GE- IVWDKKKHFATVRKVLS- -YPQNNIVKKTEIQT GGFSK ESIL- -AHG- 1112

CCW42055 1050 LAD-GTVWKDDIE VNNDT-GE- IVWDKKKHFATVRKVLS- -YPQNNIVKKTEIQT GGFSK ESIL- -AHG- 1112

WP_003041502 1051 FAD-GTWERPDIE T-SED-GE- IAWNKQTDFKIVRKVLS- -YPQVNIVKKTEVQT HGLDR PSPK- -PKP- 1122

WP_037593752 1043 DIQ T-NED-GE- IAWNKEKHIKILRKVLS- -YPQVNIVKKTEEQT GGFSK ESIL- -PKG- 1094

WP_049516684 1043 DIQ T-NED-GE- IAWNKEKHIKILRKVLS- -YPQVNIVKKTEEQT GGFSK ESIL- -PKG- 1094

GAD46167 1042 DIQ T-NED-GE- IAWNKEKHIKILRKVLS- -YPQVNIVKKTEEQT GGFSK ESIL- -PKG- 1093

WP_018363470 1063 YSN-GKVIVRPWE Y-SKDtGE- IAWNKRTDFEKVRKVLS- -YPQVNIVKKVETQT GGFSK ESIL- -PKG- 1125

WP_003043819 1061 LAN-GEIRKRPLIE TNGET-GE- WWNKEKDFATVRKVLA- -MPQVNIVKKTEVQT GGFSK ESIL- -SKR- 1123

WP_006269658 1042 DIQ T-NED-GE- IAWNKEKHIKILRKVLS- -YPQVNIVKKTEEQT GGFSK ESIL- -PKG- 1093

WP_048800889 1052 FAD- GTWERPDIE T-SED-GE- IAWNKQTDFKIVRKVLS- -YPQVNIVKKVEKQT GRFSK ESIL- -PKG- 1113

WP_012767106 1051 LAN- ^■GEIRKRPLIE TNEET-GE- IVWDKGRDFATVRKVLS- -MPQVNIVKKTEVQT GALTN ESIY- -ARG- 1113

WP_014612333 1051 LAN- ^■GEIRKRPLIE TNEET-GE- IVWDKGRDFATVRKVLS- -MPQVNIVKKTEVQT GALTN ESIY- -ARG- 1113

WP_015017095 1051 LAN- ^■GEIRKRPLIE TNEET-GE- IVWNKGRDFATVRKVLS- -MPQVNIVKKTEVQT GALTN ESIY- -ARG- 1113

WP_015057649 1051 LAN- ^■GEIRKRPLIE TNEET-GE- IVWDKGRDFATVRKVLS- -MPQVNIVKKTEVQT GALTN ESIY- -ARG- 1113

WP_048327215 1051 LAN- ^■GEIRKRPLIE TNEET-GE- IVWDKGRDFATVRKVLS- -MPQVNIVKKTEVQT GALTN ESIY- -ARG- 1113

WP_049519324 1051 LAN- ^■GEIRKRPLIE TNEET-GE- IVWDKGRDFATVRKVLS- -MPQVNIVKKTEVQT GALTN ESIY- -ARG- 1113

WP_012515931 1044 L H VNSD- -GE- EIWNANKHLPIIKNVLS- -IPQVNIVKKTEVQT GGFYK ESIL- -SKG- 1094

WP_021320964 1044 L H VNSD- -GE- EIWNANKHLPIIKNVLS- -IPQVNIVKKTEVQT GGFYK ESIL- -SKG- 1094

WP_037581760 1044 L H VNSD- -GE- EIWNANKHLPIIKNVLS- -IPQVNIVKKTEVQT GGFYK ESIL- -SKG- 1094

WP_004232481 1062 YAD- ^■GRVFERPDIE T-NAD-GE- WWNKQRDFNIVRKVLS- -YPQVNIVKKVEVQT GGFSK ESIL- -PKG- 1123

WP_009854540 1057 YAD- ^■GTVFERPIIE T-NAD-GE- IAWNKQIDFEKVRKVLS- -YPQVNIVKKVETQT GGFSK ESIL- -PKG- 1118

WP_012962174 1057 YSN- ^■GKVWRPVIE C-SKDtGE- IAWNKQTDFEKVRRVLS- -YPQVNIVKKVETQT GGFSK ESIL- -PKG- 1119

WP_039695303 1059 YAD- ^■GTVFERPIIE T-NAD-GE- IAWNKQIDFEKVRKVLS- -YPQVNIVKKVETQT GGFSK ESIL- -PKG- 1120

WP_014334983 1062 YAD- ^■GRVFERPDIE T-NAD-GE- WWNKQKDFDIVRKVLS- -YPQVNIVKKVEAQT GGFSK ESIL- -SKG- 1123

WP_003099269 1052 LAD- ^■DTIFTRPQIE VNTET-GE- IVWDKVKDMQTIRKVMS- -YPQVNIVMKTEVQT GGFSK ESIW- -PKG- 1114

AHY15608 1052 LAD- ^■DTIFTRPQIE VNTET-GE- IVWDKVKDMQTIRKVMS- -YPQVNIVMKTEVQT GGFSK ESIW- -PKG- 1114

AHY17476 1052 LAD- ^■DTIFTRPQIE VNTET-GE- IVWDKVKDMQTIRKVMS- -YPQVNIVMKTEVQT GGFSK ESIW- -PKG- 1114

ESR09100

AGM98575 1052 LAD-DTIFTRPQIE VNTET-GE- IVWDKVKDMQTIRKVMS- -YPQVNIVMKTEVQT GGFSK ESIW- -PKG- 1114

ALF27331 1042 DVR T-DKN-GE- IIWKKDEHISNIKKVLS- -YPQVNIVKKVEEQT GGFSK ESIL- -PKG- 1093

WP_018372492 1056 —K K —DQEtGE- IVWDKKEIENIVKKVIY- -SSPVNIVKKREEQS GALFK QSNM- -AVGy 1108

WP_045618028 1057 YAD-GTIVKRENIE Y--SKDtGE- IAWNKEKDFATIKKVLS- -LPQVNIVKKTEEQT GGLFD NNIV- -SKKk 1124

WP_045635197 1056 YAD-GTIVKRENIE Y--SKDtGE- IAWNKEKDFAIIKKVLS- -LPQVNIVKKREVQT GGFSK ESIL- -PKG- 1118

WP_002263549 1042 DVR T--DKN-GE- IIWKKDEHISNIKKVLS- -YPQVNIVKKVEEQT GGFSK ESIL- -PKG- 1093

WP_002263887 1042 DVR T--DKN-GE- IIWKKDEHISNIKKVLS- -YPQVNIVKKVEEQT GGFSK ESIL- -PKG- 1093

WP_002264920 1042 DVR T--DKN-GE- IIWKKDEYISNIKKVLS- -YPQVNIVKKVEEQT GGFSK ESIL- -PKG- 1093

WP 002269043 1042 DVR T--DKN-GE- IIWKKDEHISNIKKVLS- -YPQVNIVKKVEEQT GGFSK ESIL- -PKG- 1093

WP 002269448 1042 DVR T-^■DKN-^■GE- IIWKKDEHISNIKKVLS--YPQVNIVKKVEEQT GGFSK ESIL- PKG- 1093

WP ^"002271977 1042 DVR T- ^■DKN- ^■GE- IIWKKDEHISNIKKVLS- -YPQVNIVKKVEEQT GGFSK ESIL- PKG- 1093

WP ^"002272766 1042 DVR T- ^■DKN- ^■GE- IIWKKDEHISNIKKVLS- -YPQVNIVKKVEEQT GGFSK ESIL- PKG- 1093

WP ^"002273241 1042 DVR T- ^■DKN- ^■GE- IIWKKDEHISNIKKVLS- -YPQVNIVKKVEEQT GGFSK ESIL- PKG- 1093

WP ^"002275430 1042 DVR T- ^■DKN- ^■GE- IIWKKDEHISNIKKVLS- -YPQVNIVKKVEEQT GGFSK ESIL- PKG- 1093

WP ^"002276448 1042 DVR T- ^■DRN- ^■GE- IIWKKDEHISNIKKVLS- -YPQVNIVKKVEEQT GGFSK ESIL- PKG- 1093

WP ^"002277050 1047 LAD- ^■DQIVERPMIE VNDET- ^■GE- IAWDKTKHITTVKKVLS- -YPQVNIVKKVEEQT GGLFD PKS- 1111

WP ^"002277364 1042 DVR T- ^■DKN- ^■GE- IIWKKDEHISNIKKVLS- -YPQVNIVKKVEEQT GGFSK ESIL- PKG- 1093

WP ^"002279025 1042 DVR T- ^■DKN- ^■GE- IIWKKDEHISNIKKVLS- -YPQVNIVKKVEEQT GGFSK ESIL- PKG- 1093

WP ^"002279859 1042 DVR T- ^■DKN- ^■GE- IIWKKDEYISNIKKVLS- -YPQVNIVKKVEEQT GGFSK ESIL- PKG- 1093

WP ^"002280230 1042 DVR T- ^■DKN- ^■GE- IIWKKDEHISNIKKVLS- -YPQVNIVKKVEEQT GGFSK ESIL- PKG- 1093

WP ^"002281696 1042 DVR T- ^■DKN- ^■GE- IIWKKDEHISNIKKVLS- -YPQVNIVKKVEEQT GGFSK ESIL- PKG- 1093

WP ^"002282247 1047 LAD- ^■DQIVERPMIE VNDET- ^■GE- IAWDKTKHITTVKKVLS- -YPQVNIVKKVEEQT GGLFD PKS- 1111

WP ^"002282906 1042 DVR I- ^■DKN- ^■GE- IIWKKDEHISNIKKVLS- -YPQVNIVKKVEEQT GGFSK ESIL- PKG- 1093

WP ^"002283846 1042 DVR T- ^■DKN- ^■GE- IIWKKDEHISNIKKVLS- -YPQVNIVKKVEEQT GGFSK ESIL- PKG- 1093

WP ^"002287255 1042 DVR T- ^■DKN- ^■GE- IIWKKDEHISNIKKVLS- -YPQVNIVKKVEEQT GGFSK ESIL- PKG- 1093

WP ^"002288990 1042 DVR T- ^■DKN- ^■GE- IIWKKDEHISNIKKVLS- -YPQVNIVKKVEEQT GGFSK ESIL- PKG- 1093

WP ^"002289641 1042 DVR T- ^■DKN- ^■GE- IIWKKDEHISNIKKVLS- -YPQVNIVKKVEEQT GGFSK ESIL- PKG- 1093

WP ^"002290427 1042 DVR T- ^■DKN- ^■GE- IIWKKDEYISNIKKVLS- -YPQVNIVKKVEEQT GGFFK ESIL- PKG- 1093

WP ^"002295753 1042 DVR T- ^■DKN- ^■GE- IIWKKDEYISNIKKVLS- -YPQVNIVKKVEEQT GGFSK ESIL- PKG- 1093

WP ^"002296423 1042 DVR T- ^■DKN- ^■GE- IIWKKDEHISNIKKVLS- -YPQVNIVKKVEEQT GGFSK ESIL- PKG- 1093

WP ^"002304487 1056 DVR T- ^■DKN- ^■GE- IIWKKDEHISNIKKVLS- -YPQVNIVKKVEEQT GGFSK ESIL- PKG- 1107

WP ^"002305844 1042 DVR T- ^■DKN- ^■GE- IIWKKDEHISNIKKVLS- -YPQVNIVKKVEEQT GGFSK ESIL- PKG- 1093

WP ^"002307203 1042 DVR T- ^■DKN- ^■GE- IIWKKDEYISNIKKVLS- -YPQVNIVKKVEEQT GGFSK ESIL- PKG- 1093

WP ^"002310390 1042 DVR T- ^■DKN- ^■GE- IIWKKDEYISNIKKVLS- -YPQVNIVKKVEEQT GGFFK ESIL- PKG- 1093

WP ^"002352408 1042 DVR T- ^■DKN- ^■GE- IIWKKDEYISNIKKVLS- -YPQVNIVKKVEEQT GGFSK ESIL- PKG- 1093

WP ^"012997688 1042 DVR T- ^■DKN- ^■GE- IIWKKDEHISNIKKVLS- -YPQVNIVKKVEEQT GGFSK ESIL- PKG- 1093

WP ^"014677909 1042 DVR T- ^■DKN- ^■GE- IIWKKDEHISNIKKVLS- -YPQVNIVKKVEEQT GGFSK ESIL- PKG- 1093

WP ^"019312892 1042 DVR T- ^■DKN- ^■GE- IIWKKDEHISNIKKVLS- -YPQVNIVKKVEEQT GGFSK ESIL- PKG- 1093

WP ^"019313659 1042 DVR T- ^■DKN- ^■GE- IIWKKDEHISNIKKVLS- -YPQVNIVKKVEEQT GGFSK ESIL- PKG- 1093

WP ^"019314093 1042 DVR T- ^■DKN- ^■GE- IIWKKDEYISNIKKVLS- -YPQVNIVKKVEEQT GGFSK ESIL- PKG- 1093

WP ^"019315370 1042 DVR T- ^■DKN- ^■GE- IIWKKDEHISNIKKVLS- -YPQVNIVKKVEEQT GGFSK ESIL- PKG- 1093

WP ^"019803776 1042 DVR T- ^■DKN- ^■GE- IIWKKDEHISNIKKVLS- -YPQVNIVKKVEEQT GGFSK ESIL- PKG- 1093

WP ^"019805234 1042 DVR T- ^■DKN- ^■GE- IIWKKDEYISNIKKVLS- -YPQVNIVKKVEEQT GGFFK ESIL- PKG- 1093

WP ^"024783594 1042 DVR T- ^■DKN- ^■GE- IIWKKDEHISNIKKVLS- -YPQVNIVKKVEEQT GGFSK ESIL- PKG- 1093

WP ^"024784288 1047 LAD- ^■DQIVERPMIE VNDET- ^■GE- IAWDKTKHITTVKKVLS- -YPQVNIVKKVEEQT GGLFD PKS- 1111

WP ^"024784666 1042 DVR T- ^■DKN- ^■GE- IIWKKDEHISNIKKVLS- -YPQVNIVKKVEEQT GGFSK ESIL- PKG- 1093

WP ^"024784894 1042 DVR T- ^■DKN- ^■GE- IIWKKDEHISNIKKVLS- -YPQVNIVKKVEEQT GGFSK ESIL- PKG- 1093

WP ^"024786433 1047 LAD- ^■DQIVERPMIE VNDET- ^■GE- IAWDKTKHITTVKKVLS- -YPQVNIVKKVEEQT GGLFD PKS- 1111

111

WP 049473442 1042 DVR T-DKN-GE- IIWKKDEHISNIKKVLS--YPQVNIVKKVEEQT GGFSK ESIL- PKG- 1093

WP 049474547 1042 DVR T-DKN-GE- IIWKKDEHISNIKKVLS- -YPQVNIVKKVEEQT GGFSK ESIL- PKG- 1093

EMC03581 1035 DVR T-DKN-GE- IIWKKDEHISNIKKVLS- -YPQVNIVKKVEEQT GGFSK ESIL- PKG- 1086

WP 000428612 1059 YAD-GTIVKRENIE Y-SKDtGE- IAWNKEKDFATIKKVLS- -LPQVNIVKKREVQT GGFSK ESIL- PKG- 1121

WP 000428613 1057 YAD-GTIVKRENIE Y-SKDtGE- IAWNKEKDFATIKKVLS- -YPQVNIVKKREVQT GGFSK ESIL- PKG- 1119

WP 049523028 1052 YAD-GTIIQRGNVE Y-SKDtGE- IAWNKKRDFAIVRKVLS- -YPQVNIVKKTEEQT GGFSK ESIL- PKG- 1114

WP 003107102 1021 LAD-GTVITRPQIE TNTET-GE- IVWDKVKDIKTIRKVLS- -IPQINWKKTEVQT GGFSK ESIL- SKR- 1083

WP 054279288 1053 LAN-GNIIKRSPIE VNEET-GE- IVWDKTKDFGTVRKVLS- -APQVNIVKKTEIQT GGFSN ETIL- SKG- 1115

WP 049531101 1057 YAD-GTIVKRENIE Y-SKDtGE- IAWNKEIDFATIRKILS- -LSQVNIVKKTEEQT GGLFD NNIV- SKKk 1124

WP 049538452 1057 YAD-GTIVKRENIE Y-SKDtGE- IAWNKEKDFATIKKILS- -LPQVNIVKKTEEQT GGLFD NNIV- SKKk 1124

WP 049549711 1059 YAD-GTIVKRENIE Y-SKDtGE- IAWNKEKDFATIKKVLS- -YPQVNIVKKTEEQT GGLFD NNIV- ^■SKEk 1126

WP 007896501 1058 LAD-GTLMKRPVIE TNTET-GE- ^■WWDKVKDFKTIRKVLS- -YPQVNIVKKTEIQS GAFSK ESVL- ^■SKG- 1120

EFR44625 1010 LAD-GTLMKRPVIE TNTET-GE- ^■WWDKVKDFKTIRKVLS- -YPQVNIVKKTEIQS GAFSK ESVL- SKG- 1072

WP 002897477 1056 YAD-GTIRKRENIE Y-SKDtGE- IAWDKEKDFATIKKVLS- -YPQVNIVKKREVQT GGFSK ESIL- PKG- 1118

WP 002906454 1056 YAD-GTIKKRENIE Y-SNDtGE- IAWNKEKDFATIKKVLS- -LPQVNIVKKTEEQT GGLFD NNIV- SKKk 1123

WP 009729476 1057 YAD-GTIVKRENIE Y-SKDtGE- IAWNKEKDFATIKKVLS- -LPQVNIVKKREVQT GGFSK ESIL- PKG- 1119

CQR24647 1047 LAD-GRWEKPVIE ANEET-GE- IAWDKTKHFANVKKVLS- -YPQVSIVKKVEEQT GGFSK ESIL- PKG- 1109

WP 000066813 1061 YAD-GTIVKRENIE Y-SKDtGE- IAWNKEKDFATVKKVLS- -LPQVNIVKKTEVQT GGFSK ESIL- PKG- 1123

WP 009754323 1057 YAD-GTIVKRENIE Y-SKDtGE- IAWNKEKDFVTIKKVLS- -YPQVNIVKKREVQT GGFSK ESIL- PKG- 1119

WP 044674937 1049 YSKtGEVRIRPVIE VNKET-GE- IVWDKKSDFRTVRKVLS- -YPQVNWKKVEMQT GGFSK ESIL- QHG- 1112

WP 044676715 1051 YSKtGEVRIRPVIE VNKET-GE- IVWDKKSDFRTVRKVLS- -YPQVNWKKVEMQT GGFSK ESIL- QHG- 1114

WP 044680361 1051 YSKtGEVRIRPVIE VNKET-GE- IVWDKKSDFRTVRKVLS- -YPQVNWKKVEMQT GGFSK ESIL- QHG- 1114

WP 044681799 1049 YSKtGEVRIRPVIE VNKET-GE- IVWDKKSDFKTVRKVLS- -YPQVNWKKVEMQT GGFSK ESIL- QHG- 1112

WP 049533112 1051 FAD-GTWERPDIE T-SED-GE- IAWNKQTDFKIVRKVLS- -YPQVNIVKKTEVQT HGLDR PSPK- PKP- 1122

WP 029090905 1008 -KQ Q —NSTtGE- VKWNPEVDIAKLKRILN- -FKQCNIVRKVEEQS GALFK ETIY- PVEe 1061

WP 006506696 1039 —D GK- LIWNP-DLINEIKKCFY- -YKDCYCTTKLDQKS GQLFN -TVL- SNDa 1084

AIT42264 1052 LAN-GEIRKRPLIE TNGET-GE- IVWDKGRDFATVRKVLS- -MPQVNIVKKTEVQT GGFSK ESIL- PKR- 1114

WP 034440723 1042 LA —NPD-GE- IAWEKDKDLNTIRKVLS- -SKQINIIKKAEEGK GRLFK ETIN- SRPs 1092

AKQ21048 1052 LAN-GEIRKRPLIE TNGET-GE- IVWDKGRDFATVRKVLS- -MPQVNIVKKTEVQT GGFSK ESIL- PKR- 1114

WP 004636532 1043 VNEET-GE- ILWDTERHLSTIKRVLS- -WKQMNIVKKVEKQK GQLWK ETIY- PKG- 1092

WP 002364836 1048 —E P RFTKD-GE- ILWSN-SYLKTIKKELN- -YHQMNIVKKVEVQK GGFSK ESIK- PKG- 1098

WP 016631044 999 —E P RFTKD-GE- ILWSN-SYLKTIKKELN- -YHQMNIVKKVEVQK GGFSK ESIK- PKG- 1049

EMS75795 783 —E Y SYDEN-GE- ^■IFWDKARHIPQIKKVIS- -SHQVNIVKKVEVQT GGFYK ETVN- PKG- 834

WP 002373311 1048 —E P RFTKD-SE- ILWSN-SYLKTIKKELN- -YHQMNIVKKVEVQK GGFSK ESIK- PKG- 1098

WP 002378009 1048 —E P RFTKD-GE- ILWSN-SYLKTIKKELN- -YHQMNIVKKVEVQK GGFSK ESIK- PKG- 1098

WP 002407324 1048 —E P RFTKD-GE- ILWSN-SYLKTIKKELN- -YHQMNIVKKVEVQK GGFSK ESIK- PKG- 1098

WP 002413717 1048 —E P RFTKD-GE- ILWSN-SYLKTIKKELN- -YHQMNIVKKVEVQK GGFSK ESIK- PKG- 1098

WP 010775580 1050 —E P RFTKD-GE- ILWSN-SYLKTIKKELN- -YHQMNIVKKVEVQK GGFSK ESIK- PKG- 1100

WP 010818269 1048 —E P RFTKD-GE- ILWSN-SYLKTIKKELN- -YHQMNIVKKVEVQK GGFSK ESIK- PKG- 1098

WP 010824395 1048 --E- p RFTKD-^■GE- ILWSN-SYLKTIKKELN-^■YHQMNIVKKVEVQK GGFSK ESIK- PKG- 1098

WP 016622645 1048 - -E- p RFTKD- ^■GE- ILWSN-SYLKTIKKELN- ^■YHQMNIVKKVEVQK GGFSK ESIK- PKG- 1098

WP 033624816 1048 - -E- p RFTKD- ^■GE- ILWSN-SYLKTIKKELN- ^■YHQMNIVKKVEVQK GGFSK ESIK- PKG- 1098

WP 033625576 1048 - -E- p RFTKD- ^■GE- ILWSN-SYLKTIKKELN- ^■YHQMNIVKKVEVQK GGFSK ESIK- PKG- 1098

WP 033789179 1048 - -E- p RFTKD- ^■GE- ILWSN-SYLKTIKKELN- ^■YHQMNIVKKVEVQK GGFSK ESIK- PKG- 1098

WP 002310644 1049 - -T- p VCDEN- ^■GE- ^■I FWDKSKSIAQVKKVIN- ^■HHHMNIVKKTEIQK GGFSK ETVE- PKK- 1100

WP 002312694 1050 - -T- p VCDEN- ^■GE- ^■I FWDKSKSIAQVKKVIN- ^■HHHMNIVKKTEIQK GGFSK ETVE- PKK- 1101

WP 002314015 1050 - -T- p VCDEN- ^■GE- ^■I FWDKSKSIAQVKKVIN- ^■HHHMNIVKKTEIQK GGFSK ETVE- PKK- 1101

WP 002320716 1050 - -T- p VCDEN- ^■GE- ^■I FWDKSKSIAQVKKVIN- ^■HHHMNIVKKTEIQK GGFSK ETVE- PKK- 1101

WP 002330729 1049 - -T- p VCDEN- ^■GE- ^■I FWDKSKSIAQVKKVIN- ^■HHHMNIVKKTEIQK GGFSE ETVE- PKK- 1100

WP 002335161 1050 - -T- p VCDEN- ^■GE- ^■I FWDKSKSIAQVKKVIN- ^■HHHMNIVKKTEIQK GGFSK ETVE- PKK- 1101

WP 002345439 1050 - -T- p VCDEN- ^■GE- ^■I FWDKSKSIAQVKKVIN- ^■HHHMNIVKKTEIQK GGFSK ETVE- PKK- 1101

WP 034867970 1040 - -E- p FCDEN- ^■GE- IYWEKSHHLPRIKKVLS- ^■SHQVNWKKVEQQK GGFYK ETVN- SKE- 1091

WP 047937432 1050 - -T- p VCDEN- ^■GE- ^■I FWDKSKSIAQVKKVIN- ^■HHHMNIVKKTEIQK GGFSK ETVE- PKK- 1101

WP 010720994 1040 - -E- p FCDEN- ^■GE- IYWEKSHHLPRIKKVLS- ^■SHQVNWKKVEQQK GGFYK ETVN- SKE- 1091

WP 010737004 1040 - -E- p FCDEN- ^■GE- IYWEKSHHLPRIKKVLS- ^■SHQVNWKKVEQQK GGFYK ETVN- SKE- 1091

WP 034700478 1040 - -E- p FCDEN- ^■GE- IYWEKSHHLPRIKKVLS- ^■SHQVNWKKVEQQK GGFYK ETVN- SKE- 1091

WP 007209003 1038 - -D- IINDD- ^■GE- ^■ILWNKQETIAQVIKTLG- ^■MHQVNWKKVEIQK GGFSK ESIQ- PKG- 1089

WP 023519017 1034 - -E- 1 ICDEQ- ^■GE- VIWNKKRDLSTIKKTIG- ^■AHQVNIVKKVEKQK GGFYK ETIN- SKA- 1085

WP 010770040 1046 - -A- V IIDEN- ^■GE- ILWDK-KNIATVKKVMS- ^■YPQMNIVKKPEIQT GSFSK ETIK- PKG- 1096

WP 048604708 1043 - -K- V IIDEN- ^■GE- ^■ILWNQ-KKIVTVKKVMN- ^■YRQMNIVKKVEIQK GGFSK ESIL- PKG- 1093

WP 010750235 1043 - -E- Q FCDEN- ^■GE- IFWDKRKHIQQIKKVIS- ^■SHQVNIVKKVEVQT GSFYK ETVN- TKE- 1094

AII16583 1091 LAN- GEIRKRPLIE TNGET- ^■GE- IVWDKGRDFATVRKVLS- ^■MPQVNIVKKTEVQT GGFSK ESIL- PKR- 1153

WP 029073316 1053 - -D- T- ^■GE- ^■WWDP-EWISRIKKCFY- ^■YKDCFVTKKLEENN GSFFN -TVR- PNDe 1099

WP 031589969 1053 - -D- T- ^■GE- IVWDP-NYIDRIKKCFY- ^■YKDCFVTKKLEENN GTFFN -TVL- PNDt 1099

KDA45870 1035 YPF- ^■—WDKARDLPTIKRYLY- ^■RAQVNKVRKAERQT GGFSD EMLV- PKS- 1078

WP 039099354 1044 E LVDEN- ^■TEaVIWNKESGLAYLNKIYQ- ^■FKKILVTREVHENS GALFN QTLYaAKDd 1097

AKP02966 1063 - -N- -GTTQ —DRNtGE- ^■I IWNVG-FRDKILKIFN- ^■YHQCNVTRKTEIKT GQFYD QTIYs PKNp 1118

WP 010991369 1045 - -D- R IIDEN- ^■GE- ILWDK-KYLDTVKKVMS- ^■YRQMNIVKKTEIQK GEFSK ATIK- PKG- 1095

WP 033838504 1045 - -D- R IIDEN- ^■GE- ILWDK-KYLDTVKKVMS- ^■YRQMNIVKKTEIQK GEFSK ATIK- PKG- 1095

EHN60060 1048 - -D- R IIDEN- ^■GE- ILWDK-KYLDTVKKVMS- ^■YRQMNIVKKTEIQK GEFSK ATIK- PKG- 1098

EFR89594 814 - -D- R IIDEN- ^■GE- ILWDK-KYLDTVKKVMS- ^■YRQMNIVKKTEIQK GEFSK ATIK- PKG- 864

WP 038409211 1045 - -N- Q IIDKN- ^■GE- ILWDN-RYLDTIKKVLS- ^■YRQMNIVKKTEIQK GEFSN ATVN- PKG- 1095

EFR95520 664 - -N- Q IIDKN- ^■GE- ILWDN-RYLDTIKKVLS- ^■YRQMNIVKKTEIQK GEFSN ATVN- PKG- 714

WP 003723650 1045 - -E- R IIDEN- ^■GE- ILWDK-KYLETIKKVLD- ^■YRQMNIVKKTEIQK GEFSK ATIK- PKG- 1095

WP 003727705 1045 - -E- R IIDEN- ^■GE- ILWDK-KYLETIKKVLD- ^■YRQINIVKKTEIQK GEFSK ATIK- PKG- 1095

WP 003730785 1045 - -E- R IIDEN- ^■GE- ILWDK-KYLETIKKVLD- ^■YRQINIVKKTEIQK GEFSK ATIK- PKG- 1095

WP 003733029 1045 - -D- R IIDEN- ^■GE- ^■ILWDK-RYLETVKKVLG- ^■YRQMNIVKKTEIQK GEFSN VTPN- PKG- 1095

WP 003739838 1045 - -E- R IIDEN- ^■GE- ILWDK-KYLETIKKVLD- ^■YRQMNIVKKTEIQK GEFSK ATIK- PKG- 1095

WP 014601172 1045 —E- R IIDEN-^■GE- ILWDK-KYLETIKKVLD--YRQMNIVKKTEIQK GEFSK ATIK- PKG- 1095

WP 023548323 1045 —E- R IIDEN- ^■GE- ILWDK-KYLETIKKVLN- -YRQMNIVKKTEIQK GEFSN QNPK- PRG- 1095

WP 031665337 1045 —E- R IIDEN- ^■GE- ILWDK-KYLETIKKVLD- -YRQMNIVKKTEIQK GEFSK ATIK- PKG- 1095

WP 031669209 1045 —D- R IIDEN- ^■GE- ^■ILWDK-RYLETVKKVLG- -YRQMNIVKKTEIQK GEFSN VTPN- PKG- 1095

WP 033920898 1045 —E- R IIDEN- ^■GE- ILWDK-KYLETIKKVLN- -YRQMNIVKKTEIQK GEFSN QNPK- PRG- 1095

AKI42028 1048 —E- R IIDEN- ^■GE- ILWDK-KYLETIKKVLD- -YRQMNIVKKTEIQK GEFSK ATIK- PKG- 1098

AKI50529 1048 —E- R IIDEN- ^■GE- ILWDK-KYLETIKKVLN- -YRQMNIVKKTEIQK GEFSN QNPK- PRG- 1098

EFR83390 493 —E- R IIDEN- ^■GE- ILWDK-KYLETIKKVLD- -YRQMNIVKKTEIQK GEFSK ATIK- PKG- 543

WP 046323366 1045 —D- R IIDEN- ^■GE- ILWDK-KYLDTIKKVLN- -YRQMNIVKKTEIQK GEFSN ATAN- PKG- 1095

AKE81011 1068 LAN- GEIRKRPLIE TNGET- ^■GE- IVWDKGRDFATVRKVLS- -MPQVNIVKKTEVQT GGFSK ESIL- PKR- 1130

CU082355 1043 —D- ^■GK- LIWNP-DLINEIKKCFY- -YKDCYCTTKLDQKS GQMFN -TVL- PNDa 1088

WP 033162887 1043 —D- T- ^■GE- VMWDP-AKIGKIKSCFY- -YKDVYVTKKLEQNS GTLFN -TVL- PNDa 1089

AGZ 01981 1085 LAN- GEIRKRPLIE TNGET- ^■GE- IVWDKGRDFATVRKVLS- -MPQVNIVKKTEVQT GGFSK ESIL- PKR- 1147

AKA60242 1052 LAN- GEIRKRPLIE TNGET- ^■GE- IVWDKGRDFATVRKVLS- -MPQVNIVKKTEVQT GGFSK ESIL- PKR- 1114

AKS40380 1052 LAN- GEIRKRPLIE TNGET- ^■GE- IVWDKGRDFATVRKVLS- -MPQVNIVKKTEVQT GGFSK ESIL- PKR- 1114

4UN5 B 1056 LAN- GEIRKRPLIE TNGET- ^■GE- IVWDKGRDFATVRKVLS- -MPQVNIVKKTEVQT GGFSK ESIL- PKR- 1118

WP 010922251 1115 --NSD KLIA -RKKDW-^■DPKKYGGFDSPTVAYSV-^■LWAK--VE--KGKSKKLKSVKELLGITIME RSSFEK 1176

WP ^"039695303 1121 - -DSD KLIPRKTkKV-YW- ^■DTKKYGGFDSPTVAYSV- ^■FWAD- -VE- -KGKAKKLKTVKELVGISIME RSFFEE 1185

WP ^"045635197 1119 - -NSD KLIPRKT -KDILL- ^■DTTKYGGFDSPVIAYSI- ^■LLIAD- -IE- -KGKAKKLKTVKTLVGITIME KAAFEE 1183

5AXW A 853 - -EKN -LYKYYEeTGNYL- ^■—TKYSKKDNGPVIKKI- -KYYGNKLNAHLDITDDYPNS -VKLSL 912

WP 009880683 799 - -NSD KLIA -RKKDW- ^■DPKKYGGFDSPTVAYSV- ^■LWAK- -VE- -KGKSKKLKSVKELVGITIME RSSFEK 860

WP ^"010922251 1115 - -NSD KLIA -RKKDW- ^■DPKKYGGFDSPTVAYSV- ^■LWAK- -VE- -KGKSKKLKSVKELLGITIME RSSFEK 1176

WP ^"011054416 1115 - -NSD KLIA -RKKDW- ^■DPKKYGGFDSPTVAYSV- ^■LWAK- -VE- -KGKSKKLKSVKELLGITIME RSSFEK 1176

WP ^"011284745 1115 - -NSD KLIA -RKKDW- ^■DPKKYGGFDSPTVAYSV- ^■LWAK- -VE- -KGKSKKLKSVKELLGITIME RSSFEK 1176

WP ^"011285506 1115 - -NSD KLIA -RKKDW- ^■DPKKYGGFDSPTVAYSV- ^■LWAK- -VE- -KGKSKKLKSVKELLGITIME RSSFEK 1176

WP ^"011527619 1115 - -NSD KLIA -RKKDW- ^■DPKKYGGFDSPTVAYSV- ^■LWAK- -VE- -KGKSKKLKSVKELLGITIME RSSFEK 1176

WP ^"012560673 1115 - -NSD KLIA -RKKDW- ^■DPKKYGGFDSPTVAYSV- ^■LWAK- -VE- -KGKSKKLKSVKELVGITIME RSSFEK 1176

WP ^"014407541 1114 - -NSD KLIA -RKKDW- ^■DPKKYGGFDSPTVAYSV- ^■LWAK- -VE- -KGKSKKLKSVKELLGITIME RSSFEK 1175

WP ^"020905136 1115 - -NSD KLIA -RKKDW- ^■DPKKYGGFDSPTVAYSV- ^■LWAK- -VE- -KGKSKKLKSVKELLGLTIME RSSFEK 1176

WP ^"023080005 1114 - -NSD KLIA -RKKDW- ^■DPKKYGGFDSPTVAYSV- ^■LWAK- -VE- -KGKSKKLKSVKELLGITIME RSSFEK 1175

WP ^"023610282 1114 - -NSD KLIA -RKKDW- ^■DPKKYGGFDSPTVAYSV- ^■LWAK- -VE- -KGKSKKLKSVKELLGITIME RSSFEK 1175

WP ^"030125963 1115 - -NSD KLIA -RKKDW- ^■DPKKYGGFDSPTVAYSV- ^■LWAK- -VE- -KGKSKKLKSVKELLGITIME RSSFEK 1176

WP ^"030126706 1115 - -NSD KLIA -RKKDW- ^■DPKKYGGFDSPTVAYSV- ^■LWAK- -VE- -KGKSKKLKSVKELLGITIME RSSFEK 1176

WP ^"031488318 1115 - -NSD KLIA -RKKDW- ^■DPKKYGGFDSPTVAYSV- ^■LWAK- -VE- -KGKSKKLKSVKELLGITIME RSSFEK 1176

WP ^"032460140 1115 - -NSD KLIA -RKKDW- ^■DPKKYGGFDSPTVAYSV- ^■LWAK- -VE- -KGKSKKLKSVKELVGITIME RSSFEK 1176

WP ^"032461047 1115 - -NSD KLIA -RKKDW- ^■DPKKYGGFDSPTVAYSV- ^■LWAK- -VE- -KGKSKKLKSVKELVGITIME RSSFEK 1176

WP ^"032462016 1115 - -NSD KLIA -RKKDW- ^■DPKKYGGFDSPTVAYSV- ^■LWAK- -VE- -KGKSKKLKSVKELLGITIME RSSFEK 1176

WP ^"032462936 1115 - -NSD KLIA -RKKDW- ^■DPKKYGGFDSPTVAYSV- ^■LWAK- -VE- -KGKSKKLKSVKELLGITIME RSSFEK 1176

WP ^"032464890 1115 - -NSD KLIA -RKKDW- ^■DPKKYGGFDSPTVAYSV- ^■LWAK- -VE- -KGKSKKLKSVKELLGITIME RSSFEK 1176

WP ^"033888930 940 - -NSD KLIA -RKKDW- ^■DPKKYGGFDSPTVAYSV- ^■LWAK- -VE- -KGKSKKLKSVKELLGITIME RSSFEK 1001

WP ^"038431314 1115 - -NSD KLIA -RKKDW- ^■DPKKYGGFDSPTVAYSV- ^■LWAK- -VE- -KGKSKKLKSVKELLGITIME RSSFEK 1176

WP ^"038432938 1114 - -NSD KLIA -RKKDW- ^■DPKKYGGFDSPTVAYSV- ^■LWAK- -VE- -KGKSKKLKSVKELLGITIME RSSFEK 1175

WP ^"038434062 1115 - -NSD KLIA -RKKDW- ^■DPKKYGGFDSPTVAYSV- ^■LWAK- -VE- -KGKSKKLKSVKELLGITIME RSSFEK 1176

BAQ51233 1026 - -NSD KLIA -RKKDW- ^■DPKKYGGFDSPTVAYSV- ^■LWAK- -VE- -KGKSKKLKSVKELLGITIME RSSFEK 1087

KGE60162 290 - -NSD KLIA -RKKDW- ^■DPKKYGGFDSPTVAYSV- ^■LWAK- -VE- -KGKSKKLKSVKELLGITIME RSSFEK 351

KGE60856 53 - -NSD KLIA -RKKDW- ^■DPKKYGGFDSPTVAYSV- ^■LWAK- -VE- -KGKSKKLKSVKELLGITIME RSSFEK 114

WP 002989955 1115 - -NSD KLIA -RKKDW- ^■DPKKYGGFDSPTVAYSV- ^■LWAK- -VE- -KGKSKKLKSVKELLGITIME RSSFEK 1176

WP ^"003030002 1094 - -ESD KLIPRKT -KNSYW- ^■NPKKYGGFDSPWAYSI- ^■LVFAD- -VE- -KGKSKKLRKVQDMVGITIME KKRFEK 1158

WP ^"003065552 1122 - -DSD KLIPRKTkKA-YW- ^■DTKKYGGFDSPTVAYSV- ^■FWAD- -VE- -KGKAKKLKTVKELVGISIME RSFFEE 1186

WP ^"001040076 1113 - -NSD KLIPRKT -KDIYL- ^■DPKKYGGFDSPIVAYSV- ^■LWAD- -IK- -KGKAQKLKTVTELLGITIME RSRFEK 1177

WP ^"001040078 1121 - -NSD KLIPRKT -KDIYL- ^■DPKKYGGFDSPIVAYSV- ^■LWAD- -IK- -KGKAQKLKTVTELLGITIME RSKFEK 1185

WP ^"001040080 1113 - -NSD KLIPRKT -KDIYL- ^■DPKKYGGFDSPIVAYSV- ^■LWAD- -IK- -KGKAQKLKTVTELLGITIME RSRFEK 1177

WP ^"001040081 1113 - -NSD KLIPRKT -KDIYL- ^■DPKKYGGFDSPIVAYSV- ^■LWAD- -IK- -KGKAQKLKTVTELLGITIME RSRFEK 1177

WP ^"001040083 1113 - -NSD KLIPRKT -KDIYL- ^■DPKKYGGFDSPIVAYSV- ^■LWAD- -IK- -KGKAQKLKTVTELLGITIME RSRFEK 1177

WP ^"001040085 1113 - -NSD KLIPRKT -KDIYL- ^■DPKKYGGFDSPIVAYSV- ^■LWAD- -IK- -KGKAQKLKTVTELLGITIME RSRFEK 1177

WP 001040087 1113 --NSD KLIPRKT-^■KDIYL-^■DPKKYGGFDSPIVAYSV-^■LWAD--IK--KGKAQKLKTVTELLGITIME RSRFEK 1177

WP 001040088 1113 - -NSD KLIPRKT- ^■KDIYL- ^■DPKKYGGFDSPIVAYSV- ^■LWAD- -IK- -KGKAQKLKTVTELLGITIME RSRFEK 1177

WP 001040089 1113 - -NSD KLIPRKT- ^■KDIYL- ^■DPKKYGGFDSPIVAYSV- ^■LWAD- -IK- -KGKAQKLKTVTELLGITIME RSRFEK 1177

WP 001040090 1113 - -NSD KLIPRKT- ^■KDIYL- ^■DPKKYGGFDSPIVAYSV- ^■LWAD- -IK- -KGKAQKLKTVTELLGITIME RSRFEK 1177

WP 001040091 1113 - -NSD KLIPRKT- ^■KDIYL- ^■DPKKYGGFDSPIVAYSV- ^■LWAD- -IK- -KGKAQKLKTVTELLGITIME RSRFEK 1177

WP 001040092 1113 - -NSD KLIPRKT- ^■KDIYL- ^■DPKKYGGFDSPIVAYSV- ^■LVLAD- -IK- -KGKAQKLKTVKELIGITIME RERFEK 1177

WP 001040094 1113 - -NSD KLIPRKT- ^■KDIYL- ^■DPKKYGGFDSPIVAYSV- ^■LWAD- -IK- -KGKAQKLKTVTELLGITIME RSRFEK 1177

WP 001040095 1113 - -NSD KLIPRKT- ^■KDIYL- ^■DPKKYGGFDSPIVAYSV- ^■LWAD- -IK- -KGKAQKLKTVTELLGITIME RSRFEK 1177

WP 001040096 1113 - -NSD KLIPRKT- ^■KDIYL- ^■DPKKYGGFDSPIVAYSV- ^■LWAD- -IK- -KGKAQKLKTVTELLGITIME RSRFEK 1177

WP 001040097 1113 - -NSD KLIPRKT- ^■KDIYL- ^■DPKKYGGFDSPIVAYSV- ^■LWAD- -IK- -KGKAQKLKTVTELLGITIME RSRFEK 1177

WP 001040098 1113 - -NSD KLIPRKT- ^■KDIYL- ^■DPKKYGGFDSPIVAYSV- ^■LWAD- -IK- -KGKAQKLKTVTELLGITIME RSRFEK 1177

WP 001040099 1113 - -NSD KLIPRKT- ^■KDIYL- ^■DPKKYGGFDSPKVAYSV- ^■LWAD- -IK- -KGKAQKLKTVTELLGITIME RSRFEK 1177

WP 001040100 1113 - -NSD KLIPRKT- ^■KDIYL- ^■DPKKYGGFDSPIVAYSV- ^■LWAD- -IK- -KGKAQKLKTVTELLGITIME RSRFEK 1177

WP 001040104 1113 - -NSD KLIPRKT- ^■KDIYL- ^■DPKKYGGFDSPIVAYSV- ^■LWAD- -IK- -KGKAQKLKTVTELLGITIME RSRFEK 1177

WP 001040105 1113 - -NSD KLIPRKT- ^■KDIYL- ^■DPKKYGGFDSPIVAYSV- ^■LWAD- -IK- -KGKAQKLKTVTELLGITIME RSRFEK 1177

WP 001040106 1113 - -NSD KLIPRKT- ^■KDIYL- ^■DPKKYGGFDSPIVAYSV- ^■LWAD- -IK- -KGKAQKLKTVTELLGITIME RFRFEK 1177

WP 001040107 1113 - -NSD KLIPRKT- ^■KDIYL- ^■DPKKYGGFDSPIVAYSV- ^■LWAD- -IK- -KGKAQKLKTVTELLGITIME RFRFEK 1177

WP 001040108 1113 - -NSD KLIPRKT- ^■KDIYL- ^■DPKKYGGFDSPIVAYSV- ^■LWAD- -IK- -KGKAQKLKTVTELLGITIME RFRFEK 1177

WP 001040109 1113 - -NSD KLIPRKT- ^■KDIYL- ^■DPKKYGGFDSPIVAYSV- ^■LWAD- -IK- -KGKAQKLKTVTELLGITIME RFRFEK 1177

WP 001040110 1113 - -NSD KLIPRKT- ^■KDIYL- ^■DPKKYGGFDSPIVAYSV- ^■LWAD- -IK- -KGKAQKLKTVTELLGITIME RFRFEK 1177

WP 015058523 1113 - -NSD KLIPRKT- ^■KDIYL- ^■DPKKYGGFDSPIVAYSV- ^■LVLAD- -IK- -KGKAQKLKTVKELIGITIME RERFEK 1177

WP 017643650 1113 - -NSD KLIPRKT- ^■KDIYL- ^■DPKKYGGFDSPIVAYSV- ^■LWAD- -IK- -KGKAQKLKTVTELLGITIME RSRFEK 1177

WP 017647151 1113 - -NSD KLIPRKT- ^■KDIYL- ^■DPKKYGGFDSPIVAYSV- ^■LWAD- -IK- -KGKAQKLKTVTELLGITIME RSRFEK 1177

WP 017648376 1113 - -NSD KLIPRKT- ^■KDIYL- ^■DPKKYGGFDSPIVAYSV- ^■LWAD- -IK- -KGKAQKLKTVTELLGITIME RSRFEK 1177

WP 017649527 1113 - -NSD KLIPRKT- ^■KDIYL- ^■DPKKYGGFDSPIVAYSV- ^■LWAD- -IK- -KGKAQKLKTVTELLGITIME RSRFEK 1177

WP 017771611 1113 - -NSD KLIPRKT- ^■KDIYL- ^■DPKKYGGFDSPIVAYSV- ^■LWAD- -IK- -KGKAQKLKTVTELLGITIME RFRFEK 1177

WP 017771984 1113 - -NSD KLIPRKT- ^■KDIYL- ^■DPKKYGGFDSPIVAYSV- ^■LVAAD- -IK- -KGKAQKLKTVTELLGITIME RSRFEK 1177

CFQ25032 1113 - -NSD KLIPRKT- ^■KDIYL- ^■DPKKYGGFDSPIVAYSV- ^■LWAD- -IK- -KGKAQKLKTVTELLGITIME RSRFEK 1177

CFV16040 1113 - -NSD KLIPRKT- ^■KDIYL- ^■DPKKYGGFDSPIVAYSV- ^■LWAD- -IK- -KGKAQKLKTVTELLGITIME RSRFEK 1177

KLJ37842 1113 - -NSD KLIPRKT- ^■KDIYL- ^■DPKKYGGFDSPIVAYSV- ^■LWAD- -IK- -KGKAQKLKTVTELLGITIME RSRFEK 1177

KLJ72361 1113 - -NSD KLIPRKT- ^■KDIYL- ^■DPKKYGGFDSPIVAYSV- ^■LWAD- -IK- -KGKAQKLKTVTELLGITIME RSRFEK 1177

KLL20707 1127 - -NSD KLIPRKT- ^■KDIYL- ^■DPKKYGGFDSPIVAYSV- ^■LWAD- -IK- -KGKAQKLKTVTELLGITIME RSRFEK 1191

KLL42645 1113 - -NSD KLIPRKT- ^■KDIYL- ^■DPKKYGGFDSPIVAYSV- ^■LWAD- -IK- -KGKAQKLKTVTELLGITIME RFRFEK 1177

WP 047207273 1113 - -NSD KLIPRKT- ^■KDIYL- ^■DPKKYGGFDSPIVAYSV- ^■LWAD- -IK- -KGKAQKLKTVTELLGITIME RSRFEK 1177

WP 047209694 1113 - -NSD KLIPRKT- ^■KDIYL- ^■DPKKYGGFDSPIVAYSV- ^■LWAD- -IK- -KGKAQKLKTVTELLGITIME RSRFEK 1177

WP 050198062 1113 - -NSD KLIPRKT- ^■KDIYL- ^■DPKKYGGFDSPIVAYSV- ^■LWAD- -IK- -KGKAQKLKTVTELLGITIME RSRFEK 1177

WP 050201642 1113 - -NSD KLIPRKT- ^■KDIYL- ^■DPKKYGGFDSPIVAYSV- ^■LWAD- -IK- -KGKAQKLKTVTELLGITIME RSRFEK 1177

WP 050204027 1113 - -NSD KLIPRKT- ^■KDIYL- ^■DPKKYGGFDSPIVAYSV- ^■LWAD- -IK- -KGKAQKLKTVTELLGITIME RFRFEK 1177

WP 050881965 1113 - -NSD KLIPRKT- ^■KDIYL- ^■DPKKYGGFDSPIVAYSV- ^■LWAD- -IK- -KGKAQKLKTVTELLGITIME RSRFEK 1177

WP 050886065 1113 --NSD KLIPRKT-KDIYL-^■DPKKYGGFDSPIVAYSV- LWAD--IK--KGKAQKLKTVTELLGITIME RSRFEK 1177

AHN30376 1113 - -NSD KLIPRKT -KDIYL- ^■DPKKYGGFDSPIVAYSV- LVLAD- -IK- -KGKAQKLKTVKELIGITIME RERFEK 1177

EA078426 1113 - -NSD KLIPRKT -KDIYL- ^■DPKKYGGFDSPIVAYSV- LWAD- -IK- -KGKAQKLKTVTELLGITIME RSRFEK 1177

CCW42055 1113 - -NSD KLIPRKT -KDIYL- ^■DPKKYGGFDSPIVAYSV- LWAD- -IK- -KGKAQKLKTVTELLGITIME RSRFEK 1177

WP 003041502 1123 - -DSS ENLVGVK -RNL ^■DPKKYGGYAGISNSYAV- ^■LVKAI- -IE- -KGVKKKETMVLEFQGI SILD RITFEK 1185

WP 037593752 1095 - -ESD KLIPRKT -KNSYW- ^■NPKKYGGFDSPWAYSI- LVFAD- -VE- -KGKSKKLRKVQDMVGITIME KKRFEK 1159

WP 049516684 1095 - -ESD KLIPRKT -KNSYW- ^■NPKKYGGFDSPWAYSI- LVFAD- -VE- -KGKSKKLRKVQDMVGITIME KKRFEK 1159

GAD46167 1094 - -ESD KLIPRKT -KNSYW- ^■NPKKYGGFDSPWAYSI- LVFAD- -VE- -KGKSKKLRKVQDMVGITIME KKRFEK 1158

WP 018363470 1126 - -DSD KLIPRKTkKV-LW- ^■EPKKYGGFDSPTVAYSV- LWAD- -VE- -KGKTKKLKTVKELVGISIME RSFFEK 1190

WP 003043819 1124 - -ESA KLIP -RKKGW- ^■DTRKYGGFGSPTVAYSI- LWAK- -VE- -KGKAKKLKSVKVLVGITIME KGSYEK 1185

WP 006269658 1094 - -ESD KLIPRKT -KNSYW- ^■DPKKYGGFDSPWAYSI- LVFAD- -VE- -KGKSKKLRKVQDMVGITIME KKRFEK 1158

WP 048800889 1114 - -DSD KLIARKTkEN-YW- ^■DTKKYGGFDSPTVAYSV- LWAD- -IK- -KGKAKKLKTVKELVGISIME RPFFEK 1178

WP 012767106 1114 - -SFD KLIS -RKHRF- ^■ESSKYGGFGSPTVTYSV- LWAKs kVQ- -DGKVKKIKTGKELIGMTLLD KLVFEK 1177

WP 014612333 1114 - -SFD KLIS -RKHRF- ^■ESSKYGGFGSPTVTYSV- LWAKs kVQ- -DGKVKKIKTGKELIGITLLD KLVFEK 1177

WP 015017095 1114 - -SFD KLIS -RKHRF- ^■ESSKYGGFGSPTVTYSV- LWAKs kVQ- -DGKVKKIKTGKELIGITLLD KLVFEK 1177

WP 015057649 1114 - -SFD KLIS -RKHRF- ^■ESSKYGGFGSPTVTYSV- LWAKs kVQ- -DGKVKKIKTGKELIGITLLD KLVFEK 1177

WP 048327215 1114 - -SFD KLIS -RKHRF- ^■ESSKYGGFGSPTVTYSV- ^■LWAKckVQ- -DGKVKKIKTGKELIGITLLD KLVFEK 1177

WP 049519324 1114 - -SFD KLIS -RKHRF- ^■ESSKYGGFGSPTVTYSV- LWAKs kVQ- -DGKVKKIKTGKELIGITLLD KLVFEK 1177

WP 012515931 1095 - -NSD KLIP -RKNNW- ^■DTRKYGGFDSPTVAYSV- LVIAK- -ME- -KGKAKVLKPVKEMVGITIME RTAFEE 1156

WP 021320964 1095 - -NSD KLIP -RKNNW- ^■DTRKYGGFDSPTVAYSV- LVIAK- -ME- -KGKAKVLKPVKEMVGITIME RIAFEE 1156

WP 037581760 1095 - -NSD KLIP -RKNNW- ^■DTRKYGGFDSPTVAYSV- LVIAK- -ME- -KGKAKVLKPVKEMVGITIME RIAFEE 1156

WP 004232481 1124 - -DSD KLIPRKTkKL-QW- ^■ETQKYGGFDSPTVAYSV- LWAD- -VE- -KGKTRKLKTVKELVGISIME RSSFEE 1188

WP 009854540 1119 - -DSD KLIPRKTkKV-YW- ^■DTKKYGGFDSPTVAYSV- FWAD- -VE- -KGKAKKLKTVKELVGISIME RSFFEE 1183

WP 012962174 1120 - -NSD KLIPRKTkKF-RW- ^■DTPKYGGFDSPNIAYSV- FVIAD- -VE- -KGKAKKLKTVKELVGISIME RSSFEE 1184

WP 039695303 1121 - -DSD KLIPRKTkKV-YW- ^■DTKKYGGFDSPTVAYSV- FWAD- -VE- -KGKAKKLKTVKELVGISIME RSFFEE 1185

WP 014334983 1124 - -DSD KLIPRKTkKV-YW- ^■NTKKYGGFDSPTVAYSV- LWAD- -IE- -KGKAKKLKTVKELVGISIME RSFFEE 1188

WP 003099269 1115 - -DSD KLIA -RKKSW- ^■DPKKYGGFDSPIIAYSV- LWAK- -IA- -KGKTQKLKTIKELVGIKIME QDEFEK 1176

AHY15608 1115 - -DSD KLIA -RKKSW- ^■DPKKYGGFDSPIIAYSV- LWAK- -IA- -KGKTQKLKTIKELVGIKIME QDEFEK 1176

AHY17476 1115 - -DSD KLIA -RKKSW- ^■DPKKYGGFDSPIIAYSV- LWAK- -IA- -KGKTQKLKTIKELVGIKIME QDEFEK 1176

ESR09100 1 QDEFEK

AGM98575 1115 - -DSD KLIA -RKKSW- ^■DPKKYGGFDSPIIAYSV- LWAK- -IA- -KGKTQKLKTIKELVGIKIME QDEFEK 1176

ALF27331 1094 - -NSD KLIPRKT -KKFYW- ^■DTKKYGGFDSPIVAYSI- LVIAN- -IE- -KGKSKKLKLVKDLVGITIME RTIFEK 1158

WP 018372492 1109 - —NN KLIP -RKKDW- ^■SVDKYGGFIEPAESYSLalFYTD- -IN- GKKPKKKSTIIAISRME KKDYEK 1167

WP 045618028 1125 vvDAS KLTPIKS -G L- ^■SPEKYGGYARPTIAYSV- LVIAD- -IE- -KGKAKKLKRIKEMVGITVQD KKKFEA 1188

WP 045635197 1119 - -NSD KLIPRKT -KDILL- ^■DTTKYGGFDSPVIAYSI- LLIAD- -IE- -KGKAKKLKTVKTLVGITIME KAAFEE 1183

WP 002263549 1094 - -NSD KLIPRKT -KKFYW- ^■DTKKYGGFDSPIVAYSI- LVIAD- -IE- -KGKSKKLKTVKALVGVTIME KMTFER 1158

WP 002263887 1094 - -NSD KLIPRKT -KKFYW- ^■DTKKYGGFDSPIVAYSI- LVIAD- -IE- -KGKSKKLKTVKALVGVTIME KMTFER 1158

WP 002264920 1094 - -DSD KLIPRKT -KKFYW- ^■DTKKYGGFDSPIVAYSI- LVIAD- -IE- -KGKSKKLKTVKALVGVTIME KMTFER 1158

WP 002269043 1094 - -NSD KLIPRKT -KKFYW- ^■DTKKYGGFDSPIVAYSI- LVIAD- -IE- -KGKSKKLKTVKALVGVTIME KMTFER 1158

WP 002269448 1094 --NSD KLIPRKT- KKFYW-^■DTKKYGGFDSPIVAYSI -LVIAD--IE--KGKSKKLKTVKALVGVTIME KMTFER 1158

WP ^"002271977 1094 - -NSD KLIPRKT- KKFYW- ^■DTKKYGGFDSPIVAYSI -LVIAD- -IE- -KGKSKKLKTVKALVGVTIME KMTFER 1158

WP ^"002272766 1094 - -NSD KLIPRKT- KKFYW- ^■DTKKYGGFDSPIVAYSI -LVIAD- -IE- -KGKSKKLKTVKALVGVTIME KMTFER 1158

WP ^"002273241 1094 - -NSD KLIPRKT- KKFYW- ^■DTKKYGGFDSPIVAYSI -LVIAD- -IE- -KGKSKKLKTVKALVGVTIME KMTFER 1158

WP ^"002275430 1094 - -NSD KLIPRKT- KKFYW- ^■DTKKYGGFDSPIVAYSI -LVIAD- -IE- -KGKSKKLKTVKALVGVTIME KMTFER 1158

WP ^"002276448 1094 - -NSD KLIPRKT- KKFYW- ^■DTKKYGGFDSPIVAYSI -LVIAD- -IE- -KGKSKKLKTVKALVGVTIME KMTFER 1158

WP ^"002277050 1112 - -PLE KLVPLKK- AL- ^■NPEKYGGYQKPTTAYPI -LLIVD- TKQLIPISVMD KKRFEQ 1166

WP ^"002277364 1094 - -NSD KLIPRKT- KKFYW- ^■DTKKYGGFDSPIVAYSI -LVIAD- -IE- -KGKSKKLKTVKALVGVTIME KMTFER 1158

WP ^"002279025 1094 - -NSD KLIPRKT- KKFYW- ^■DTKKYGGFDSPIVAYSI -LVIAD- -IE- -KGKSKKLKTVKALVGVTIME KMTFER 1158

WP ^"002279859 1094 - -DSD KLIPRKT- KKFYW- ^■DTKKYGGFDSPIVAYSI -LVIAD- -IE- -KGKSKKLKTVKALVGVTIME KMTFER 1158

WP ^"002280230 1094 - -NSD KLIPRKT- KKFYW- ^■DTKKYGGFDSPIVAYSI -LVIAD- -IE- -KGKSKKLKTVKALVGVTIME KMTFER 1158

WP ^"002281696 1094 - -NSD KLIPRKT- KKFYW- ^■DTKKYGGFDSPIVAYSI -LVIAD- -IE- -KGKSKKLKTVKALVGVTIME KMTFER 1158

WP ^"002282247 1112 - -PLE KLVPLKK- AL- ^■NPEKYGGYQKPTTAYPI -LLIVD- TKQLIPISVMD KKRFEQ 1166

WP ^"002282906 1094 - -NSD KLIPRKT- KKFYW- ^■DTKKYGGFDSPIVAYSI -LVIAD- -IE- -KGKSKKLKTVKALVGVTIME KMTFER 1158

WP ^"002283846 1094 - -NSD KLIPRKT- KKFYW- ^■DTKKYGGFDSPIVAYSI -LVIAD- -IE- -KGKSKKLKTVKALVGVTIME KMTFER 1158

WP ^"002287255 1094 - -NSD KLIPRKT- KKFYW- ^■DTKKYGGFDSPIVAYSI -LVIAD- -IE- -KGKSKKLKTVKALVGVTIME KMTFER 1158

WP ^"002288990 1094 - -NSY KLIPRKT- KKFYW- ^■DTKKYGGFDSPIVAYSI -LVIAD- -IE- -KGKSKKLKTVKALVGVTIME KMTFER 1158

WP ^"002289641 1094 - -NSD KLIPRKT- KKFYW- ^■DTKKYGGFDSPIVAYSI -LVIAD- -IE- -KGKSKKLKTVKALVGVTIME KMTFER 1158

WP ^"002290427 1094 - -DSD KLIPRKT- KKFYW- ^■DTKKYGGFDSPIVAYSI -LVIAD- -IE- -KGKSKKLKTVKALVGVTIME KMTFER 1158

WP ^"002295753 1094 - -NSD KLIPRKT- KKFYW- ^■DTKKYGGFDSPIVAYSI -LVIAD- -IE- -KGKSKKLKTVKALVGVTIME KMTFER 1158

WP ^"002296423 1094 - -NSD KLIPRKT- KKFYW- ^■DTKKYGGFDSPIVAYSI -LVIAD- -IE- -KGKSKKLKTVKALVGVTIME KMTFER 1158

WP ^"002304487 1108 - -NSD KLIPRKT- KKFYW- ^■DTKKYGGFDSPIVAYSI -LVIAD- -IE- -KGKSKKLKTVKALVGVTIME KMTFER 1172

WP ^"002305844 1094 - -NSD KLIPRKT- KKFYW- ^■DTKKYGGFDSPIVAYSI -LVIAD- -IE- -KGKSKKLKTVKALVGVTIME KMTFER 1158

WP ^"002307203 1094 - -NSD KLIPRKT- KKFYW- ^■DTKKYGGFDSPIVAYSI -LVIAD- -IE- -KGKSKKLKTVKALVGVTIME KMTFER 1158

WP ^"002310390 1094 - -DSD KLIPRKT- KKFYW- ^■DTKKYGGFDSPIVAYSI -LVIAD- -IE- -KGKSKKLKTVKALVGVTIME KMTFER 1158

WP ^"002352408 1094 - -DSD KLIPRKT- KKFYW- ^■DTKKYGGFDSPIVAYSI -LVIAD- -IE- -KGKSKKLKTVKALVGVTIME KMTFER 1158

WP ^"012997688 1094 - -NSD KLIPRKT- KKFYW- ^■DTKKYGGFDSPIVAYSI -LVIAD- -IE- -KGKSKKLKTVKALVGVTIME KMTFER 1158

WP ^"014677909 1094 - -NSD KLIPRKT- KKFYW- ^■DTKKYGGFDSPIVAYSI -LVIAD- -IE- -KGKSKKLKTVKALVGVTIME KMTFER 1158

WP ^"019312892 1094 - -NSD KLIPRKT- KKFYW- ^■DTKKYGGFDSPIVAYSI -LVIAD- -IE- -KGKSKKLKTVKALVGVTIME KMTFER 1158

WP ^"019313659 1094 - -NSD KLIPRKT- KKFYW- ^■DTKKYGGFDSPIVAYSI -LVIAD- -IE- -KGKSKKLKTVKALVGVTIME KMTFER 1158

WP ^"019314093 1094 - -NSD KLIPRKT- KKFYW- ^■DTKKYGGFDSPIVAYSI -LVIAD- -IE- -KGKSKKLKTVKALVGVTIME KMTFER 1158

WP ^"019315370 1094 - -NSD KLIPRKT- KKFYW- ^■DTKKYGGFDSPIVAYSI -LVIAD- -IE- -KGKSKKLKTVKALVGVTIME KMTFER 1158

WP ^"019803776 1094 - -NSD KLIPRKT- KKFYW- ^■DTKKYGGFDSPIVAYSI -LVIAD- -IE- -KGKSKKLKTVKALVGVTIME KMTFER 1158

WP ^"019805234 1094 - -DSD KLIPRKT- KKFYW- ^■DTKKYGGFDSPIVAYSI -LVIAD- -IE- -KGKSKKLKTVKALVGVTIME KMTFER 1158

WP ^"024783594 1094 - -NSD KLIPRKT- KKFYW- ^■DTKKYGGFDSPIVAYSI -LVIAD- -IE- -KSKSKKLKTVKALVGVTIME KMTFER 1158

WP ^"024784288 1112 - -PLE KLVPLKK- AL- ^■NPEKYGGYQKPTTAYPI -LLIVD- TKQLIPISVMD KKRFEQ 1166

WP ^"024784666 1094 - -NSD KLIPRKT- KKFYW- ^■DTKKYGGFDSPIVAYSI -LVIAD- -IE- -KGKSKKLKTVKALVGVTIME KMTFER 1158

WP ^"024784894 1094 - -NSD KLIPRKT- KKFYW- ^■DTKKYGGFDSPIVAYSI -LVIAD- -IE- -KGKSKKLKTVKALVGVTIME KMTFER 1158

WP ^"024786433 1112 - -PLE KLVPLKK- AL- ^■NPEKYGGYQKPTTAYPI -LLIVD- TKQLIPISVMD KKRFEQ 1166

WP 049473442 1094 —NSD KLIPRKT-KKFYW-^■DTKKYGGFDSPIVAYSI-^■LVIAD--IE--KGKSKKLKTVKALVGVTIME KMTFER 1158

WP 049474547 1094 —NSD KLIPRKT -KKFYW- ^■DTKKYGGFDSPIVAYSI- ^■LVIAD- -IE- -KGKSKKLKTVKALVGVTIME KMTFER 1158

EMC03581 1087 —NSD KLIPRKT -KKFYW- ^■DTKKYGGFDSPIVAYSI- ^■LVIAD- -IE- -KGKSKKLKTVKALVGVTIME KMTFER 1151

WP 000428612 1122 —NSD KLIPRKT -KDILW- ^■DTTKYGGFDSPVIAYSI- ^■LLIAD- -IE- -KGKAKRLKTVKTLVGITIME KATFEK 1186

WP 000428613 1120 —NSD KLIPRKT -KDILW- ^■ETTKYGGFDSPVIAYSI- ^■LLIAD- -IE- -KGKAKKLKTVKTLVGITIME KAAFEE 1184

WP 049523028 1115 —NSD KLIPRKT -KNVQL- ^■DTTKYGGFDSPVIAYSI- ^■LLVAD- -VE- -KGKSKKLKTVKSLIGITIME KVKFEA 1179

WP 003107102 1084 —DSD KLIP -RKNNW- ^■DPKKYGGFGSPIIAYSV- ^■LWAK- -VT- -KGKSQKTKSVKELVGITIME QNEFEK 1145

WP 054279288 1116 —KSS KLIP -RKNKWrDTTKYGGFNTPTVAYSV- ^■LWAK- -VE- -KGKAKKLKPVKELVGITIME RTKFEA 1178

WP 049531101 1125 vvDAS KLIPIKS -G L- ^■SPEKYGGYARPTIAYSV- ^■LVIAD- -IE- -KGKAKKLKRIKEMVGITIQD KKKFEA 1188

WP 049538452 1125 vvDAS KLIPIKS -G L- ^■SPEKYGGYARPTIAYSV- ^■LVIAD- -IE- -KGKTKKLKRIKEMIGITVQD KKIFES 1188

WP 049549711 1127 vvDAS KLIPIKS -G L- ^■SPEKYGGYARPTIAYSV- ^■LVIAD- -IE- -KGKTKKLKRIKEMVGITIQD KKKFEA 1190

WP 007896501 1121 —NSD KLIE -RKKGW- ^■DPKKYGGFDSPNTAYSI- ^■FWAK- -VA- -KRKAQKLKTVKEIVGITIME QAEYEK 1182

EFR44625 1073 —NSD KLIE -RKKGW- ^■DPKKYGGFDSPNTAYSI- ^■FWAK- -VA- -KRKAQKLKTVKEIVGITIME QAEYEK 1134

WP 002897477 1119 —NSD KLIPRKT -KDILW- ^■DTTKYGGFDSPVIAYSI- ^■LLIAD- -IE- -KGKAKKLKTVKTLVGITIME KAAFEE 1183

WP 002906454 1124 vvDAS KLIPIKS -S L- ^■SPEKYGGYARPTIAYSV- ^■LVIAD- -lEkgKGKAKKLKRIKEIVGITIQD KKKFES 1189

WP 009729476 1120 —NSD KLIPRKT -KDILW- ^■DTTKYGGFDSPVIAYSI- ^■LLIAD- -IE- -KGKAKKLKTVKTLVGITIME KDAFEK 1184

CQR24647 1110 —GSD KLIARKT -KNNYL- ^■STQKYGGFDSPTVAYSI- ^■MFVAD- -IE- -KGKSKRLKTVKEMIGITIME RSRFES 1174

WP 000066813 1124 —NSD KLIPRKT -KEILW- ^■DTTKYGGFDSPVIAYSI- ^■LLIAD- -IE- -KGKAKKLKTVKTLVGITIME KATFEK 1188

WP 009754323 1120 —NSD KLIPRKT -KDILW- ^■DTTKYGGFDSPVIAYSI- ^■LLIAD- -IE- -KGKAKKLKTVKTLVGITIME KAAFEK 1184

WP 044674937 1113 —DSD KLIPRKT -EKFYL- ^■DTKKYGGFDSPTIAYSV- ^■LLIAD- -IE- -KGKAKKLKRVKELIGITIME RMAFEK 1177

WP 044676715 1115 —DSD KLIPRKT -EKFYL- ^■DTKKYGGFDSPTIAYSV- ^■LLIAD- -IE- -KGKAKKLKRVKELIGITIME RMAFEK 1179

WP 044680361 1115 —DSD KLIPRKT -EKFYL- ^■DTKKYGGFDSPTIAYSV- ^■LLIAD- -IE- -KGKAKKLKRVKELIGITIME RMAFEK 1179

WP 044681799 1113 —DSD KLIPRKT -EKFYL- ^■DTKKYGGFDSPTIAYSV- ^■LLIAD- -IE- -KGKAKKLKRVKELIGITIME RMAFEK 1177

WP 049533112 1123 —DSS ENLVGVK -RNL ^■DPKKYGGYAGISNSYAV- ^■LVKAI- -IE- -KGVKKKETMVLEFQGI SILD RITFEK 1185

WP 029090905 1062 —SSS KTIP -LKKHL- ^■DTAIYGGYTA YASYA- ^■—LIQ- -FK- KGRKLK—REIIGIPLAV QTRIDN 1117

WP 006506696 1085 haDKG AWP ^■vNKNRS- ^■DVHKYGGFSG—LQYTI- VA- -lEgqKKKGKKTELVKKISGVPLHL KAASIN 1149

AIT42264 1115 —NSD KLIA -RKKDW- ^■DPKKYGGFDSPTVAYSV- ^■LWAK- -VE- -KGKSKKLKSVKELLGITIME RSSFEK 1176

WP 034440723 1093 k-KTE KRIP -IKNNL- ^■DPNIYGGYIEEKMAYYI- AInyLE- -NGKTKK AIVGISIKD KKDFEG 1149

AKQ21048 1115 —NSD KLIA -RKKDW- ^■DPKKYGGFDSPTVAYSV- ^■LWAK- -VE- -KGKSKKLKSVKELLGITIME RSSFEK 1176

WP 004636532 1093 —DSS KLIP -VKEGM- ^■DPQKYGGLSQVSEAFAV- ^■VIT— -HE- -KGKKKQLK—SDLISIPIVD QKAYEQ 1150

WP 002364836 1099 —PSN KLIP -VKNGL- ^■DPQKYGGFDSPIVAYTV- ^■LF—T- -HE- -KGK-KPL-IKQEILGITIME KTRFEQ 1156

WP 016631044 1050 —PSN KLIP -VKNGL- ^■DPQKYGGFDSPWAYTV- ^■LF—T- -HE- -KGK-KPL-IKQEILGITIME KTRFEQ 1107

EMS75795 835 —KPD KLIQ -RKAGW- ^■DVSKYGGFGSPWAYAV- ^■AFI -YE- -KGKAR—KKAKAIEGITIMK QSLFEQ 892

WP 002373311 1099 —PSN KLIP -VKNGL- ^■DPQKYGGFDSPWAYTV- ^■LF—T- -HE- -KGK-KPL-IKQEILGITIME KTRFEQ 1156

WP 002378009 1099 —PSN KLIP -VKNGL- ^■DPQKYGGFDSPIVAYTV- ^■LF—T- -HE- -KGK-KPL-IKQEILGITIME KTRFEQ 1156

WP 002407324 1099 —PSN KLIP -VKNGL- ^■DPQKYGGFDSPIVAYTV- ^■LF—T- -HE- -KGK-KPL-IKQEILGITIME KTRFEQ 1156

WP 002413717 1099 —PSN KLIP -VKNGL- ^■DPQKYGGFDSPWAYTV- ^■LF—T- -HE- -KGK-KPL-IKQEILGITIME KTRFEQ 1156

WP 010775580 1101 —PSN KLIP -VKNGL- ^■DPQKYGGFDSPWAYTV- ^■LF—T- -HE- -KGK-KPL-IKQEILGITIME KTRFEQ 1158

WP 010818269 1099 —PSN KLIP -VKNGL- ^■DPQKYGGFDSPIVAYTV- ^■LF—T- -HE- -KGK-KPL-IKQEILGITIME KTRFEQ 1156

WP 010824395 1099 --PSN KLIP- VKNGL-^■DPQKYGGFDSPWAYTV--LF—^■T--HE--KGK-KPL-IKQEILGITIME KTRFEQ 1156

WP ^"016622645 1099 - -PSN KLIP- VKNGL- ^■DPQKYGGFDSPIVAYTV- -LF— ^■T- -HE- -KGK-KPL-IKQEILGITIME KTRFEQ 1156

WP ^"033624816 1099 - -PSN KLIP- VKNGL- ^■DPQKYGGFDSPWAYTV- -LF— ^■T- -HE- -KGK-KPL-IKQEILGITIME KTRFEQ 1156

WP ^"033625576 1099 - -PSN KLIP- VKNGL- ^■DPQKYGGFDSPWAYTV- -LF— ^■T- -HE- -KGK-KPL-IKQEILGITIME KTKFEQ 1156

WP ^"033789179 1099 - -PSN KLIP- VKNGL- ^■DPQKYGGFDSPWAYTV- -LF— ^■T- -HE- -KGK-KPL-IKQEILGITIME KTRFEQ 1156

WP ^"002310644 1101 - -DSS KLLP- RKNNW- ^■DPAKYGGLGSPNVAYTV- -AFT- -YE- -KGKAR—KRTNALEGITIME REAFEQ 1158

WP ^"002312694 1102 - -DSS KLLP- RKNNW- ^■DPAKYGGLGSPNVAYTV- -AFT- -YE- -KGKAR—KRTNALEGITIME REAFEQ 1159

WP ^"002314015 1102 - -DSS KLLP- RKNNW- ^■DPAKYGGLGSPNVAYTV- -AFT- -YE- -KGKAR—KRTNALEGITIME REAFEQ 1159

WP ^"002320716 1102 - -DSS KLLP- RKNNW- ^■DPAKYGGLGSPNVAYTV- -AFT- -YE- -KGKAR—KRTNALEGITIME REAFEQ 1159

WP ^"002330729 1101 - -DSS KLLP- RKNNW- ^■DPAKYGGLGSPNVAYTV- -AFT- -YE- -KGKAR—KRTNALEGITIME REAFEQ 1158

WP ^"002335161 1102 - -DSS KLLP- RKNNW- ^■DPAKYGGLGSPNVAYTV- -AFT- -YE- -KGKAR—KRTNALEGITIME REAFEQ 1159

WP ^"002345439 1102 - -DSS KLLP- RKNNW- ^■DPTKYGGLGSPNVAYTV- -AFT- -YE- -KGKAR—KRTNALEGITIME REAFEQ 1159

WP ^"034867970 1092 - -KPD KLIE- RKNNW- ^■DVTKYGGFGSPVIAYAI- -AFV- -YA- -KGKTQ—KKTRAIEGITIME QAAFEK 1149

WP ^"047937432 1102 - -DSS KLLP- RKNNW- ^■DPAKYGGLGSPNVAYTV- -AFT- -YE- -KGKAR—KRTNALEGITIME REAFEQ 1159

WP ^"010720994 1092 - -KPD KLIE- RKNNW- ^■DVTKYGGFGSPVIAYAI- -AFV- -YA- -KGKTQ—KKTKAIEGITIME QAAFEK 1149

WP ^"010737004 1092 - -KPD KLIE- RKNNW- ^■DVTKYGGFGSPVIAYAI- -AFV- -YA- -KGKTQ—KKTRAIEGITIME QAAFEK 1149

WP ^"034700478 1092 - -KPD KLIE- RKNNW- ^■DVTKYGGFGSPVIAYAI- -AFV- -YA- -KGKTQ—KKTRAIEGITIME QAAFEK 1149

WP ^"007209003 1090 - -ESQ KLIR- RKQQW- ^■NTKKYGGFDSPWAYAI- -—LLS- -FD- -KGK-RKARSFK-IVGITIQD RESFEG 1147

WP ^"023519017 1086 - -NPE KLIP- RKASL- ^■DPLKYGGYGSPLVAYTV- -IFI- -FE- -KGKQK—KVTKGIEGITVME QLRFEQ 1143

WP ^"010770040 1097 - -DSD KLIS- RKTNW- ^■SPKLYGGFDSPQVAYSV- -II— ^■T- -YE- -KGK-KKVRA-KAIVGITIME QSLFKK 1154

WP ^"048604708 1094 - -DSD KLIS- RKKEW- ^■DTTKYGGFDSPNVAYSV- -VI— ^■R- -YE- -KGK-TRKLV-KTIVGITIME RAAFEK 1151

WP ^"010750235 1095 - -KPD KLIK- RKNNW- ^■DVTKYGGFGSPWAYAV- -VFT- -YE- -KGKNH—KKAKAIEGITIME QALFEK 1152

AII16583 1154 - -NSD KLIA- RKKDW- ^■DPKKYGGFDSPTVAYSV- -LWAK- -VE- -KGKSKKLKSVKELLGITIME RSSFEK 1215

WP 029073316 1100 hsEKG AKVP- — NKLRS- ^■NVHKYGGFEG—LKYSI- VA- -IKgkKKKGKKI IDVNKLVGI PLMY KNVDDE 1164

WP ^"031589969 1100 nsDKD ATVP- — NKYRS- ^■NVNKYGGFSG—VNSFI- VA- -IKgkKKKGKKVIEVNKLTGIPLMY KNADEE 1164

KDA45870 1079 - -DSG KLLP- RKEGL- ^■DPVKYGGYAKAVESYAV- -LITAD-eVK- -KGKTKKVKT LVNIPIID SKKYEA 1138

WP 039099354 1098 k -ASG QLI PAKQdRPTAL- YGGYSGKTVAYMC- -—IVR- -1KnkKGDLYKVCGVETSWLAQLKQ KKAFLK 1170

AKP02966 1119 k KLIA- QKKDM- ^■DPNIYGGFSGDNKSSIT- -—IVK- -ID- NNKIKPVA—IPIRLIN DK 1172

WP 010991369 1096 - -NSS KLIP- RKTNW- ^■DPMKYGGLDSPNMAYAV- -VI— ^■E- -YA- -KGK-NKLVFEKKIIRVTIME RKAFEK 1154

WP ^"033838504 1096 - -NSS KLIS- RKTNW- ^■DPMKYGGLDSPNMAYAV- -VI— ^■E- -YA- -KGK-NKLVFEKKIIRVTIME RKAFEK 1154

EHN60060 1099 - -NSS KLIS- RKTNW- ^■DPMKYGGLDSPNMAYAV- -VI— ^■E- -YA- -KGK-NKLVFEKKIIRVTIME RKAFEK 1157

EFR89594 865 - -NSS KLIP- RKTNW- ^■DPMKYGGLDSPNMAYAV- -VI— ^■E- -YA- -KGK-NKLVFEKKIIRVTIME RKAFEK 923

WP 038409211 1096 - -NSS KLIS- RKADW- ^■NPIKYGGFDGSNMAYSI- -VI— ^■E- -YE- -KRK-KKTVIKKELIQINIME RVAFEK 1154

EFR95520 715 - -NSS KLIS- RKADW- ^■NPIKYGGFDGSNMAYSI- -VI— ^■E- -YE- -KRK-KKTVIKKELIQINIME RVAFEK 773

WP 003723650 1096 - -NSS KLIP- RKENW- ^■DPMKYGGLDSPNMAYAV- -II— ^■E- -HA- -KGK-KKIVIEKKLIQINIME RKMFEK 1154

WP ^"003727705 1096 - -NSS KLIP- RKENW- ^■DPMKYGGLDSPNMAYAV- -II— ^■E- -HA- -KGK-KKIVIEKKLIQINIME RKMFEK 1154

WP ^"003730785 1096 - -NSS KLIP- RKENW- ^■DPVKYGGLDSPNMAYAV- -II— ^■E- -HA- -KGK-KKIVIEKKLIQINIME RKMFEK 1154

WP ^"003733029 1096 - -KSN KLIP- RKKDW- ^■DPIKYGGFDGSKMAYAI- -II— ^■E- -YE- -KQK-RKVRIEKKLIQINIME REAFEK 1154

WP ^"003739838 1096 - -NSS KLIP- RKENW- ^■DPMKYGGLDSPNMAYAV- -II— ^■E- -HA- -KGK-KKWFEKKIIRITIME RKAFEK 1154

WP 014601172 1096 —NSS KLIP- RKENW-^■DPMKYGGLDSPNMAYAV-^■II—E--HA--KGK-KKLIFEKKIIRITIME RKMFEK 1154

WP 023548323 1096 —DSS KLIP- KKTNL- ^■NPIKYGGFEGSNMAYAI- ^■II—E- -HE- -KRK-KKVTIEKKLIQINIME RKAFEK 1154

WP 031665337 1096 —NSS KLIP- RKENW- ^■DPMKYGGLDSPNMAYAV- ^■II—E- -HA- -KGK-KRIVIEKKLIQINIME RKMFEK 1154

WP 031669209 1096 —KSN KLIP- RKKDW- ^■DPIKYGGFDGSKMAYAI- ^■II—E- -YE- -KQK-RKVRIEKKLIQINIME REAFEK 1154

WP 033920898 1096 —DSS KLIP- KKTNL- ^■NPIKYGGFEGSNMAYAI- ^■II—E- -HE- -KRK-KKVTIEKKLIQINIME RKAFEK 1154

AKI42028 1099 —NSS KLIP- RKENW- ^■DPMKYGGLDSPNMAYAV- ^■II—E- -HA- -KGK-KKLIFEKKIIRITIME RKMFEK 1157

AKI50529 1099 —DSS KLIP- KKTNL- ^■NPIKYGGFEGSNMAYAI- ^■II—E- -HE- -KRK-KKVTIEKKLIQINIME RKAFEK 1157

EFR83390 544 —NSS KLIP- RKENW- ^■DPMKYGGLDSPNMAYAV- ^■II—E- -HA- -KGK-KKIVIEKKLIQINIME RKMFEK 602

WP 046323366 1096 —NSS KLIP- RKADW- ^■DPIKYGGFDGSNMAYAI- ^■VI—E- -HE- -KRK-KKTVIKKELIQINIME RTAFEK 1154

AKE81011 1131 —NSD KLIA- RKKDW- ^■DPKKYGGFDSPTVAYSV- LWAK- -VE- -KGKSKKLKSVKELLGITIME RSSFEK 1192

CU082355 1089 hsAKG AVIP- — NKNRK- ^■D KYGGFSG—LQYVI- AA- -lEgtKKKGKKLVKVRKLSGIPLYL KQADIK 1153

WP 033162887 1090 hsEKG ATVP- —1NKYRA- ^■DVHKYGGFGN—VQS11- VA- -lEgkKKKGKKLIDVRKLTSIPLHL KNAPVE 1154

AGZ 01981 1148 —NSD KLIA- RKKDW- ^■DPKKYGGFDSPTVAYSV- LWAK- -VE- -KGKSKKLKSVKELLGITIME RSSFEK 1209

AKA60242 1115 —NSD KLIA- RKKDW- ^■DPKKYGGFDSPTVAYSV- LWAK- -VE- -KGKSKKLKSVKELLGITIME RSSFEK 1176

AKS40380 1115 —NSD KLIA- RKKDW- ^■DPKKYGGFDSPTVAYSV- LWAK- -VE- -KGKSKKLKSVKELLGITIME RSSFEK 1176

4UN5 B 1119 —NSD KLIA- RKKDW- ^■DPKKYGGFDSPTVAYSV- LWAK- -VE- -KGKSKKLKSVKELLGITIME RSSFEK 1180

WP 010922251 1177 NPI---DFLE---AKGYKE--V-^■KKDLIIK--LPKYSLFE LENGRKRMLAS -G|E|LQKGNELALPSKY FLYLA 1239

WP ^"039695303 1186 NPV- - -EFLE- - -NKGYHN- -I- ^■REDKLIK- -LPKYSLFE FEGGRRRLLAS ASELQKGNEMVLPGYLVELLYHA 1248

WP ^"045635197 1184 NPI- - -TFLE- - -NKGYHN- -V- ^■RKENILC- -LPKYSLFE LENGRRRLLAS AKELQKGNEIVLPVYLTTLLYHS 1246

5AXW A 913 KPYrfdVYLD- - -NGVYKFvtV- ^■KNLDVIK- KENYYE — SKAYEEAKK -KKISNQAEFIASFYNNDLIKIN 978

WP 009880683 861 DPV- - -DFLE- - -AKGYKE- -V- ^■RKDLIIK- -LPKYSLFE —LENGRKRMLAS -GELQKGNELALPSKY FLYLA 923

WP ^"010922251 1177 NPI- - -DFLE- - -AKGYKE- -V- ^■KKDLIIK- -LPKYSLFE —LENGRKRMLAS -GELQKGNELALPSKY FLYLA 1239

WP ^"011054416 1177 DPI- - -DFLE- - -AKGYKE- -V- ^■RKDLIIK- -LPKYSLFE —LENGRKRMLAS -GELQKGNELALPSKYWFLYLA 1239

WP ^"011284745 1177 NPI- - -DFLE- - -AKGYKE- -V- ^■RKDLIVK- -LPKYSLFE —LENGRKRMLAS -GELQKGNELALPSKYWFLYLA 1239

WP ^"011285506 1177 NPI- - -DFLE- - -AKGYKE- -V- ^■KKDLIIK- -LPKYSLFE —LENGRKRMLAS -GELQKGNELALPSKYWFLYLA 1239

WP ^"011527619 1177 NPI- - -DFLE- - -AKGYKE- -V- ^■RKDLIIK- -LPKYSLFE —LENGRKRMLAS -GELQKGNELALPSKYWFLYLA 1239

WP ^"012560673 1177 DPV- - -DFLE- - -AKGYKE- -V- ^■RKDLIIK- -LPKYSLFE —LENGRKRMLAS -GELQKGNELALPSKYWFLYLA 1239

WP ^"014407541 1176 NPI- - -DFLE- - -AKGYKE- -V- ^■KKDLIIK- -LPKYSLFE —LENGRKRMLAS -GELQKGNELALPSKYWFLYLA 1238

WP ^"020905136 1177 NPI- - -DFLE- - -AKGYKE- -V- ^■KKDLIIK- -LPKYSLFE —LENGRKRMLAS -GELQKGNELALPSKYWFLYLA 1239

WP ^"023080005 1176 NPI- - -DFLE- - -AKGYKE- -V- ^■RKDLIIK- -LPKYSLFE —LENGRKRMLAS -GELQKGNELALPSKYWFLYLA 1238

WP ^"023610282 1176 NPI- - -DFLE- - -AKGYKE- -V- ^■RKDLIIK- -LPKYSLFE —LENGRKRMLAS -GELQKGNELALPSKYWFLYLA 1238

WP ^"030125963 1177 NPI- - -DFLE- - -AKGYKE- -V- ^■RKDLIIK- -LPKYSLFE —LENGRKRMLAS -GELQKGNELALPSKYWFLYLA 1239

WP ^"030126706 1177 NPI- - -DFLE- - -AKGYKE- -V- ^■RKDLIIK- -LPKYSLFE —LENGRKRMLAS -GELQKGNELALPSKYWFLYLA 1239

WP ^"031488318 1177 NPI- - -DFLE- - -AKGYKE- -V- ^■RKDLIIK- -LPKYSLFE —LENGRKRMLAS -GELQKGNELALPSKYWFLYLA 1239

WP ^"032460140 1177 DPV- - -DFLE- - -AKGYKE- -V- ^■RKDLIIK- -LPKYSLFE —LENGRKRMLAS -GELQKGNELALPSKYWFLYLA 1239

WP ^"032461047 1177 DPV- - -DFLE- - -AKGYKE- -V- ^■RKDLIIK- -LPKYSLFE —LENGRKRMLAS -GELQKGNELALPSKYWFLYLA 1239

WP ^"032462016 1177 NPI- - -DFLE- - -AKGYKE- -V- ^■KKDLIIK- -LPKYSLFE —LENGRKRMLAS -GELQKGNELALPSKYWFLYLA 1239

WP ^"032462936 1177 NPI- - -DFLE- - -AKGYKE- -V- ^■RKDLIIK- -LPKYSLFE —LENGRKRMLAS -GELQKGNELALPSKYWFLYLA 1239

WP ^"032464890 1177 NPI- - -DFLE- - -AKGYKE- -V- ^■RKDLIIK- -LPKYSLFE —LENGRKRMLAS -GELQKGNELALPSKYWFLYLA 1239

WP ^"033888930 1002 NPI- - -DFLE- - -AKGYKE- -V- ^■KKDLIIK- -LPKYSLFE —LENGRKRMLAS -GELQKGNELALPSKYWFLYLA 1064

WP ^"038431314 1177 NPI- - -DFLE- - -AKGYKE- -V- ^■RKDLIIK- -LPKYSLFE —LENGRKRMLAS -GELQKGNELALPSKYWFLYLA 1239

WP ^"038432938 1176 NPI- - -DFLE- - -AKGYKE- -V- ^■RKDLIIK- -LPKYSLFE —LENGRKRMLAS -GELQKGNELALPSKYWFLYLA 1238

WP ^"038434062 1177 NPI- - -DFLE- - -AKGYKE- -V- ^■RKDLIIK- -LPKYSLFE —LENGRKRMLAS -GELQKGNELALPSKYWFLYLA 1239

BAQ51233 1088 NPI- - -DFLE- - -AKGYKE- -V- ^■KKDLIIK- -LPKYSLFE —LENGRKRMLAS -GELQKGNELALPSKYWFLYLA 1150

KGE60162 352 DPI- - -DFLE- - -AKGYKE- -V- ^■RKDLIIK- -LPKYSLFE —LENGRKRMLAS -GELQKGNELALPSKYWFLYLA 414

KGE60856 115 DPI- - -DFLE- - -AKGYKE- -V- ^■RKDLIIK- -LPKYSLFE —LENGRKRMLAS -GELQKGNELALPSKYWFLYLA 177

WP 002989955 1177 NPI- - -DFLE- - -AKGYKE- -V- ^■RKDLIIK- -LPKYSLFE —LENGRKRMLAS -GELQKGNELALPSKYWFLYLA 1239

WP ^"003030002 1159 HPV- - -DFLE- - -QRGYRN- -V- ^■RLEKIIK- -LPKYSLFE LENKRRRLLAS ARELQKGNELVIPQRFTTLLYHS 1221

WP ^"003065552 1187 NPV- - -EFLE- - -NKGYHN- -I- ^■REDKLIK- -LPKYSLFE FEGGKRRLLAS ASELQKGNEMVIPGHLVKLLYHA 1249

WP ^"001040076 1178 NPS- - -AFLE- - -SKGYLN- -I- ^■RTDKLII- -LPKYSLFE LENGRRRLLAS AGELQKGNELALPTQFMKFLYLA 1240

WP ^"001040078 1186 NPS- - -AFLE- - -SKGYLN- -I- ^■RDDKLMI- -LPKYSLFE LENGRRRLLAS AGELQKGNELALPTQFMKFLYLA 1248

WP ^"001040080 1178 NPS- - -AFLE- - -SKGYLN- -I- ^■RADKLII- -LPKYSLFE LENGRRRLLAS AGELQKGNELALPTQFMKFLYLA 1240

WP ^"001040081 1178 NPS- - -AFLE- - -SKGYLN- -I- ^■RADKLII- -LPKYSLFE LENGRRRLLAS AGETIDRLQKGNELALPTQFMKFLYLA 12

WP ^"001040083 1178 NPS- - -AFLE- - -SKGYLN- -I- ^■RADKLII- -LPKYSLFE LENGRRRLLAS AGELQKGNELALPTQFMKFLYLA 1240

WP ^"001040085 1178 NPS- - -AFLE- - -SKGYLN- -I- ^■RADKLII- -LPKYSLFE LENGRRRLLAS AGELQKGNELALPTQFMKFLYLA 1240

WP 001040087 1178 NPS-—AFLE---SKGYLN--I -RADKLII--LPKYSLFE LENGRRRLLAS AGELQKGNELALPTQFMKFLYLA 1240

WP 001040088 1178 NPS- —AFLE- - -SKGYLN- -I -RADKLII- -LPKYSLFE LENGRRRLLAS AGELQKGNELALPTQFMKFLYLA 1240

WP 001040089 1178 NPS- —AFLE- - -SKGYLN- -I -RDDKLMI- -LPKYSLFE LENGRRRLLAS AGELQKGNELALPTQFMKFLYLA 1240

WP 001040090 1178 NPS- —AFLE- - -SKGYLN- -I -RADKLII- -LPKYSLFE LENGRRRLLAS AGELQKGNELALPTQFMKFLYLA 1240

WP 001040091 1178 NPS- —AFLE- - -SKGYLN- -I -RADKLII- -LPKYSLFE LENGRRRLLAS AGELQKGNELALPTQFMKFLYLA 1240

WP 001040092 1178 NPS- —AFLE- - -SKGYLN- -I -RTDKLII- -LPKYSLFE LENGRRRLLAS AGELQKGNELALPTQYMKFLYLA 1240

WP 001040094 1178 NPS- —AFLE- - -SKGYLN- -I -RDDKLMI- -LPKYSLFE LENGRRRLLAS AGELQKGNELALPTQFMKFLYLA 1240

WP 001040095 1178 NPS- —AFLE- - -SKGYLN- -I -RTDKLII- -LPKYSLFE LENGRRRLLAS AGELQKGNELALPTQYMKFLYLA 1240

WP 001040096 1178 NPS- —AFLE- - -SKGYLN- -I -RTDKLII- -LPKYSLFE LENGRRRLLAS AGELQKGNELALPTQYMKFLYLA 1240

WP 001040097 1178 NPS- —AFLE- - -SKGYLN- -I -RDDKLMI- -LPKYSLFE LENGRRRLLAS ADELQKGNELALPTQFMKFLYLA 1240

WP 001040098 1178 NPS- —AFLE- - -SKGYLN- -I -RDDKLMI- -LPKYSLFE LENGRRRLLAS AGELQKGNELALPTQFMKFLYLA 1240

WP 001040099 1178 NPS- —AFLE- - -SKGYLN- -I -RDDKLMI- -LPKYSLFE LENGRRRLLAS AGELQKGNELALPTQFMKFLYLA 1240

WP 001040100 1178 NPS- —AFLE- - -SKGYLD- -I -RDDKLMI- -LPKYSLFE LENGRRRLLAS AGELQKGNELALPTQFMKFLYLA 1240

WP 001040104 1178 NPS- —AFLE- - -SKGYLN- -I -RADKLII- -LPKYSLFE LENGRRRLLAS AGELQKGNELALPTQFMKFLYLA 1240

WP 001040105 1178 NPS- —AFLE- - -SKGYLN- -I -RADKLII- -LPKYSLFE LENGRRRLLAS AGELQKGNELALPTQFMKFLYLA 1240

WP 001040106 1178 NPS- —AFLE- - -SKGYLN- -I -RDDKLMI- -LPKYSLFE LENGRRRLLAS AGELQKGNELALPTQYMKFLYLA 1240

WP 001040107 1178 NPS- —AFLE- - -SKGYLN- -I -RDDKLMI- -LPKYSLFE LENGRRRLLAS AGELQKGNELALPTQYMKFLYLA 1240

WP 001040108 1178 NPS- —AFLE- - -SKGYLN- -I -RDDKLMI- -LPKYSLFE LENGRRRLLAS AGELQKGNELALPTQYMKFLYLA 1240

WP 001040109 1178 NPS- —AFLE- - -SKGYLN- -I -RDDKLMI- -LPKYSLFE LENGRRRLLAS AGELQKGNELALPTQYMKFLYLA 1240

WP 001040110 1178 NPS- —AFLE- - -SKGYLN- -I -RDDKLMI- -LPKYSLFE LENGRRRLLAS AGELQKGNELALPTQYMKFLYLA 1240

WP 015058523 1178 NPS- —AFLE- - -SKGYLN- -I -RTDKLII- -LPKYSLFE LENGRRRLLAS AGELQKGNELALPTQYMKFLYLA 1240

WP 017643650 1178 NPS- —AFLE- - -SKGYLN- -I -RDDKLMI- -LPKYSLFE LENGRRRLLAS ADELQKGNELALPTQFMKFLYLA 1240

WP 017647151 1178 NPS- —AFLE- - -SKGYLN- -I -RDDKLMI- -LPKYSLFE LENGRRRLLAS AGELQKGNELALPTQFMKFLYLA 1240

WP 017648376 1178 NPS- —AFLE- - -SKGYLN- -I -RDDKLMI- -LPKYSLFE LENGRRRLLAS AGELQKGNELALPTQFMKFLYLA 1240

WP 017649527 1178 NPS- —AFLE- - -SKGYLN- -I -RADKLII- -LPKYSLFE LENGRRRLLAS AGELQKGNELALPTQFMKFLYLA 1240

WP 017771611 1178 NPS- —AFLE- - -SKGYLN- -I -RDDKLMI- -LPKYSLFE LENGRRRLLAS AGELQKGNELALPTQYMKFLYLA 1240

WP 017771984 1178 NPS- —AFLE- - -SKGYLN- -I -RADKLII- -LPKYSLFE LENGRRRLLAS AGELQKGNELALPTQFMKFLYLA 1240

CFQ25032 1178 NPS- —AFLE- - -SKGYLN- -I -RADKLII- -LPKYSLFE LENGRRRLLAS AGELQKGNELALPTQFMKFLYLA 1240

CFV16040 1178 NPS- —AFLE- - -SKGYLN- -I -RADKLII- -LPKYSLFE LENGRRRLLAS AGELQKGNELALPTQFMKFLYLA 1240

KLJ37842 1178 NPS- —AFLE- - -SKGYLN- -I -RADKLII- -LPKYSLFE LENGRRRLLAS AGELQKGNELALPTQFMKFLYLA 1240

KLJ72361 1178 NPS- —AFLE- - -SKGYLN- -I -RADKLII- -LPKYSLFE LENGRRRLLAS AGELQKGNELALPTQFMKFLYLA 1240

KLL20707 1192 NPS- —AFLE- - -SKGYLN- -I -RADKLII- -LPKYSLFE LENGRRRLLAS AGELQKGNELALPTQFMKFLYLA 1254

KLL42645 1178 NPS- —AFLE- - -SKGYLN- -I -RDDKLMI- -LPKYSLFE LENGRRRLLAS AGELQKGNELALPTQYMKFLYLA 1240

WP 047207273 1178 NPS- —AFLE- - -SKGYLN- -I -RADKLII- -LPKYSLFE LENGRRRLLAS AGELQKGNELALPTQFMKFLYLA 1240

WP 047209694 1178 NPS- —AFLE- - -SKGYLN- -I -RDDKLMI- -LPKYSLFE LENGRRRLLAS AGELQKGNELALPTQFMKFLYLA 1240

WP 050198062 1178 NPS- —AFLE- - -SKGYLN- -I -RADKLII- -LPKYSLFE LENGRRRLLAS AGELQKGNELALPTQFMKFLYLA 1240

WP 050201642 1178 NPS- —AFLE- - -SKGYLN- -I -RADKLII- -LPKYSLFE LENGRRRLLAS AGELQKGNELALPTQFMKFLYLA 1240

WP 050204027 1178 NPS- —AFLE- - -SKGYLN- -I -RDDKLMI- -LPKYSLFE LENGRRRLLAS AGELQKGNELALPTQYMKFLYLA 1240

WP 050881965 1178 NLS- —AFLE- - -SKGYLN- -I -RADKLII- -LPKYSLFE LENGRRRLLAS AGELQKGNELALPTQFMKFLYLA 1240

WP 050886065 1178 NPS—-AFLE-—SKGYLN--I-^■RADKLII--LPKYSLFE-—LENGRRRLLAS AGELQKGNELALPTQFMKFLYLA 1240

AHN30376 1178 NPS— -AFLE- —SKGYLN- -I- ^■RTDKLII- -LPKYSLFE- —LENGRRRLLAS AGELQKGNELALPTQYMKFLYLA 1240

EA078426 1178 NPS— -AFLE- —SKGYLN- -I- ^■RADKLII- -LPKYSLFE- —LENGRRRLLAS AGELQKGNELALPTQFMKFLYLA 1240

CCW42055 1178 NPS— -AFLE- —SKGYLN- -I- ^■RTDKLII- -LPKYSLFE- —LENGRRRLLAS AGELQKGNELALPTQFMKFLYLA 1240

WP 003041502 1186 DKR— -AFLL- —GKGYKD- -I- ^■K—KIIE- -LPKYSLFE- —LKDGSRRMLAS RGEIHKGNELFVPQKFTTLLYHA 1253

WP 037593752 1160 NPV— -DFLE- —QRGYRN- -V- ^■RLEKIIK- -LPKYSLFE- —LENKRRRLLAS ARELQKGNELVI PQRFTTLLYHS 1222

WP 049516684 1160 HPV— -DFLE- —QRGYRN- -V- ^■RLEKIIK- -LPKYSLFE- —LENKRRRLLAS ARELQKGNELVI PQRFTTLLYHS 1222

GAD46167 1159 NPV— -DFLE- —QRGYRN- -V- ^■RLEKIIK- -LPKYSLFE- —LENKRRRLLAS ARELQKGNELVI PQRFTTLLYHS 1221

WP 018363470 1191 NPV— -EFLK- —NKGYQN- -V- ^■QEDKLMK- -LPKYSLFE- —FEGGRRRLLAS ATELQKGNEIMLSAHLVALLYHA 1253

WP 003043819 1186 DPI— -GFLE- —AKGYKD- -I- ^■KKELIFK- -LPKYSLFE- —LENGRRRMLAS —ELQKANELVLPQHLVRLLYYT 1248

WP 006269658 1159 NPV— -DFLE- —QRGYRN- -V- ^■RLEKIIK- -LPKYSLFE- —LENKRRRLLAS AKELQKGNELVI PQRFTTLLYHS 1221

WP 048800889 1179 NPI— -MFLE- —SKGYRN- -I- ^■QKDKLIK- -LPKYSLFE- —FEGGRRRLLAS AVELQKGNEMVLPQYLNNLLYHA 1241

WP 012767106 1178 NPL— -KFIE- —DKGYGN- -V- ^■QIDKCIK- -LPKYSLFE- —FENGTRRMLAS RGDLQKANEMFLPAKLVTLLY— 1245

WP 014612333 1178 NPL— -KFIE- —DKGYGN- -V- ^■QIDKCIK- -LPKYSLFE- —FENGTRRMLAS RGDLQKANEMFLPAKLVTLLY— 1245

WP 015017095 1178 NPL— -KFIE- —DKGYGN- -V- ^■QIDKCIK- -LPKYSLFE- —FENGTRRMLAS RGDLQKANEMFLPAKLVTLLY— 1245

WP 015057649 1178 NPL— -KFIE- —DKGYGN- -V- ^■QIDKCIK- -LPKYSLFE- —FENGTRRMLAS RGDLQKANEMFLPAKLVTLLY— 1245

WP 048327215 1178 NPL— -KFIE- —DKGYGN- -V- ^■QIDKCIK- -LPKYSLFE- —FENGTRRMLAS RGDLQKANEMFLPAKLVTLLY— 1245

WP 049519324 1178 NPL— -KFIE- —DKGYGN- -V- ^■QIDKCIK- -LPKYSLFE- —FENGTRRMLAS RGDLQKANEMFLPAKLVTLLY— 1245

WP 012515931 1157 NPV— -VFLE- —ARGYRE- -I- ^■QEHLIIK- -LPKYSLFE- —LENGRRRLLAS -SELQKGNELFLPVDYMTFLYLA 1219

WP 021320964 1157 NPV— -VFLE- —AKGYRE- -I- ^■QEHLIIK- -LPKYSLFE- —LENGRRRLLAS -SELQKGNELFLPVDYMTFLYLA 1219

WP 037581760 1157 NPV— -VFLE- —AKGYRE- -I- ^■QEHLIIK- -LPKYSLFE- —LENGRRRLLAS -SELQKGNELFLPVDYMTFLYLA 1219

WP 004232481 1189 NPV— -SFLE- —KKGYHN- -V- ^■QEDKLIK- -LPKYSLFE- —FEGGRRRLLAS ATELQKGNEWLPQYMVNLLYHS 1251

WP 009854540 1184 NPV— -EFLE- —NKGYHN- -I- ^■REDKLIK- -LPKYSLFE- —FEGGRRRLLAS ASELQKGNEMVLPGYLVELLYHA 1246

WP 012962174 1185 NPV— -VFLE- —KKGYQN- -V- ^■QEDNLIK- -LPKYSLFE- —FEGGRRRLLAS ASELQKGNEWLSRHLVELLYHA 1247

WP 039695303 1186 NPV— -EFLE- —NKGYHN- -I- ^■REDKLIK- -LPKYSLFE- —FEGGRRRLLAS ASELQKGNEMVLPGYLVELLYHA 1248

WP 014334983 1189 NPV— -SFLE- —KKGYHN- -V- ^■QEDKLIK- -LPKYSLFE- —FEGGRRRLLAS ATELQKGNEVMLPAHLVELLYHA 1251

WP 003099269 1177 DPI— -AFLE- —KKGYQD- -I- ^■QTSSIIK- -LPKYSLFE- —LENGRKRLLAS —ELQKGNELALPNKYVKFLYLA 1239

AHY15608 1177 DPI— -AFLE- —KKGYQD- -I- ^■QTSSIIK- -LPKYSLFE- —LENGRKRLLAS —ELQKGNELALPNKYVKFLYLA 1239

AHY17476 1177 DPI— -AFLE- —KKGYQD- -I- ^■QTSSIIK- -LPKYSLFE- —LENGRKRLLAS —ELQKGNELALPNKYVKFLYLA 1239

ESR09100 9 DPI— -AFLE- —KKGYQD- -I- ^■QTSSIIK- -LPKYSLFE- —LENGRKRLLAS -KELQKGNELALPNKYVKFLYLA 71

AGM98575 1177 DPI— -AFLE- —KKGYQD- -I- ^■QTSSIIK- -LPKYSLFE- —LENGRKRLLAS —ELQKGNELALPNKYVKFLYLA 1239

ALF27331 1159 NPV— -AFLE- —RKGYRN- -V- ^■QEENIVK- -LPKYSLFE- —LENGRRRLLAS ARELQKGNEIVLPNHLGTMLYHA 1221

WP 018372492 1168 EPEr- —FLA- —QKGFER- -V- ^■EKT—IK- -LPKYSLFE- —MEKGRRRLLAS SGELQKGNQVLLPEHLIRLLSYA 1228

WP 045618028 1189 NPI— -AYLE- —ECGYKN- -I- ^■NPNLIIK- -LPKYSLFE- —FNNGQRRLLAS SIELQKGNELIVPYHFTALLYHA 1251

WP 045635197 1184 NPI— -TFLE- —NKGYHN- -V- ^■RKENILC- -LPKYSLFE- —LENGRRRLLAS AKELQKGNEIVLPVYLTTLLYHS 1246

WP 002263549 1159 DPV— -AFLE- —RKGYRN- -V- ^■QEENIIK- -LPKYSLFK- —LENGRKRLLAS ARELQKGNEIVLPNHLGTLLYHA 1221

WP 002263887 1159 DPV— -AFLE- —RKGYRN- -V- ^■QEENIIK- -LPKYSLFK- —LENGRKRLLAS ARELQKGNEIVLPNHLGTLLYHA 1221

WP 002264920 1159 DPV— -AFLE- —RKGYRN- -V- ^■QEENIIK- -LPKYSLFK- —LENGRKRLLAS ARELQKGNEIVLPNHLGTLLYHA 1221

WP 002269043 1159 DPV— -AFLE- —RKGYRN- -V- ^■QEENIIK- -LPKYSLFK- —LENGRKRLLAS ARELQKGNEIVLPNHLGTLLYHA 1221

WP 002269448 1159 DPV-—AFLE---RKGYRN--V-^■QEENIIK--LPKYSLFK- LENGRKRLLAS ARELQKGNEIVLPNHLGTLLYHA 1221

WP ^"002271977 1159 DPV- —AFLE- - -RKGYRN- -V- ^■QEENIIK- -LPKYSLFK- LENGRKRLLAS ARELQKGNEIVLPNHLGTLLYHA 1221

WP ^"002272766 1159 DPV- —AFLE- - -RKGYRN- -V- ^■QEENIIK- -LPKYSLFK- LENGRKRLLAS ARELQKGNEIVLPNHLGTLLYHA 1221

WP ^"002273241 1159 DPV- —AFLE- - -RKGYRN- -V- ^■QEENIIK- -LPKYSLFK- LENGRKRLLAS ARELQKGNEIVLPNHLGTLLYHA 1221

WP ^"002275430 1159 DPV- —AFLE- - -RKGYRN- -V- ^■QEENIIK- -LPKYSLFK- LENGRKRLLAS ARELQKGNEIVLPNHLGTLLYHA 1221

WP ^"002276448 1159 DPV- —AFLE- - -RKGYRN- -V- ^■QEENIIK- -LPKYSLFK- LENGRKRLLAS ARELQKGNEIVLPNHLGTLLYHA 1221

WP ^"002277050 1167 NPV- —KFLK- - -DKGYQQ- -I- ^■EKNNFVK- -LPKYTLVD- IGNGIKRLWAS SKEVHKGNQLWSKKSQDLLYHA 1229

WP ^"002277364 1159 DPV- —AFLE- - -RKGYRN- -V- ^■QEENIIK- -LPKYSLFK- LENGRKRLLAS ARELQKGNEIVLPNHLGTLLYHA 1221

WP ^"002279025 1159 DPV- —AFLE- - -RKGYRN- -V- ^■QEENIIK- -LPKYSLFK- LENGRKRLLAS ARELQKGNEIVLPNHLGTLLYHA 1221

WP ^"002279859 1159 DPV- —AFLE- - -RKGYRN- -V- ^■QEENIIK- -LPKYSLFK- LENGRKRLLAS ARELQKGNEIVLPNHLGTLLYHA 1221

WP ^"002280230 1159 DPV- —AFLE- - -RKGYRN- -V- ^■QEENIIK- -LPKYSLFK- LENGRKRLLAS ARELQKGNEIVLPNHLGTLLYHA 1221

WP ^"002281696 1159 DPV- —AFLE- - -RKGYRN- -V- ^■QEENIIK- -LPKYSLFK- LENGRKRLLAS ARELQKGNEIVLPNHLGTLLYHA 1221

WP ^"002282247 1167 NPV- —KFLK- - -DKGYQQ- -I- ^■EKNNFVK- -LPKYTLVD- IGNGIKRLWAS SKEVHKGNQLWSKKSQDLLYHA 1229

WP ^"002282906 1159 DPV- —AFLE- - -RKGYRN- -V- ^■QEENIIK- -LPKYSLFK- LENGRKRLLAS ARELQKGNEIVLPNHLGTLLYHA 1221

WP ^"002283846 1159 DPV- —AFLE- - -RKGYRN- -V- ^■QEENIIK- -LPKYSLFK- LENGRKRLLAS ARELQKGNEIVLPNHLGTLLYHA 1221

WP ^"002287255 1159 DPV- —AFLE- - -RKGYRN- -V- ^■QEENIIK- -LPKYSLFK- LENGRKRLLAS ARELQKGNEIVLPNHLGTLLYHA 1221

WP ^"002288990 1159 DPV- —AFLE- - -RKGYRN- -V- ^■QEENIIK- -LPKYSLFK- LENGRKRLLAS ARELQKGNEIVLPNHLGTLLYHA 1221

WP ^"002289641 1159 DPV- —AFLE- - -RKGYRN- -V- ^■QEENIIK- -LPKYSLFK- LENGRKRLLAS ARELQKGNEIVLPNHLGTLLYHA 1221

WP ^"002290427 1159 DPV- —AFLE- - -RKGYRN- -V- ^■QEENIIK- -LPKYSLFK- LENGRKRLLAS ARELQKGNEIVLPNHLGTLLYHA 1221

WP ^"002295753 1159 DPI- —AFLE- - -RKGYRN- -V- ^■QEENIIK- -LPKYSLFK- LENGRKRLLAS ARELQKGNEIVLPNHLGTLLYHA 1221

WP ^"002296423 1159 DPV- —AFLE- - -RKGYRN- -V- ^■QEENIIK- -LPKYSLFK- LENGRKRLLAS ARELQKGNEIVLPNHLGTLLYHA 1221

WP ^"002304487 1173 DPV- —AFLE- - -RKGYRN- -V- ^■QEENIIK- -LPKYSLFK- LENGRKRLLAS ARELQKGNEIVLPNHLETLLYHA 1235

WP ^"002305844 1159 DPV- —AFLE- - -RKGYRN- -V- ^■QEENIIK- -LPKYSLFK- LENGRKRLLAS ARELQKGNEIVLPNHLGTLLYHA 1221

WP ^"002307203 1159 DPI- —AFLE- - -RKGYRN- -V- ^■QEENIIK- -LPKYSLFK- LENGRKRLLAS ARELQKGNEIVLPNHLGTLLYHA 1221

WP ^"002310390 1159 DPV- —AFLE- - -RKGYRN- -V- ^■QEENIIK- -LPKYSLFK- LENGRKRLLAS ARELQKGNEIVLPNHLGTLLYHA 1221

WP ^"002352408 1159 DPV- —AFLE- - -RKGYRN- -V- ^■QEENIIK- -LPKYSLFK- LENGRKRLLAS ARELQKGNEIVLPDHLGTLLYHA 1221

WP ^"012997688 1159 DPV- —AFLE- - -RKGYRN- -V- ^■QEENIIK- -LPKYSLFK- LENGRKRLLAS ARELQKGNEIVLPNHLGTLLYHA 1221

WP ^"014677909 1159 DPV- —AFLE- - -RKGYRN- -V- ^■QEENIIK- -LPKYSLFK- LENGRKRLLAS ARELQKGNEIVLPNHLGTLLYHA 1221

WP ^"019312892 1159 DPV- —AFLE- - -RKGYRN- -V- ^■QEENIIK- -LPKYSLFK- LENGRKRLLAS ARELQKGNEIVLPNHLGTLLYHA 1221

WP ^"019313659 1159 DPV- —AFLE- - -RKGYRN- -V- ^■QEENIIK- -LPKYSLFK- LENGRKRLLAS ARELQKGNEIVLPNHLGTLLYHA 1221

WP ^"019314093 1159 DPI- —AFLE- - -RKGYRN- -V- ^■QEENIIK- -LPKYSLFK- LENGRKRLLAS ARELQKGNEIVLPNHLGTLLYHA 1221

WP ^"019315370 1159 DPV- —AFLE- - -RKGYRN- -V- ^■QEENIIK- -LPKYSLFK- LENGRKRLLAS ARELQKGNEIVLPNHLGTLLYHA 1221

WP ^"019803776 1159 DPV- —AFLE- - -RKGYRN- -V- ^■QEENIIK- -LPKYSLFK- LENGRKRLLAS ARELQKGNEIVLPNHLGTLLYHA 1221

WP ^"019805234 1159 DPV- —AFLE- - -RKGYRN- -V- ^■QEENIIK- -LPKYSLFK- LENGRKRLLAS ARELQKGNEIVLPNHLGTLLYHA 1221

WP ^"024783594 1159 DPV- —AFLE- - -RKGYRN- -V- ^■QEENIIK- -LPKYSLFK- LENGRKRLLAS ARELQKGNEIVLPNHLGTLLYHA 1221

WP ^"024784288 1167 NPV- —KFLK- - -DKGYQQ- -I- ^■EKNNFVK- -LPKYTLVD- IGNGIKRLWAS SKEVHKGNQLWSKKSQDLLYHA 1229

WP ^"024784666 1159 DPV- —AFLE- - -RKGYRN- -V- ^■QEENIIK- -LPKYSLFK- LENGRKRLLAS ARELQKGNEIVLPNHLGTLLYHA 1221

WP ^"024784894 1159 DPV- —AFLE- - -RKGYRN- -V- ^■QEENIIK- -LPKYSLFK- LENGRKRLLAS ARELQKGNEIVLPNHLGTLLYHA 1221

WP ^"024786433 1167 NPV- —KFLK- - -DKGYQQ- -I- ^■EKNNFVK- -LPKYTLVD- IGNGIKRLWAS SKEVHKGNQLWSKKSQDLLYHA 1229

WP 049473442 1159 DPV---AFLE---RKGYRN--V-^■QEENIIK--LPKYSLFK- -LENGRKRLLAS ARELQKGNEIVLPNHLGTLLYHA 1221

WP 049474547 1159 DPV- - -AFLE- - -RKGYRN- -V- ^■QEENIIK- -LPKYSLFK- -LENGRKRLLAS ARELQKGNEIVLPNHLGTLLYHA 1221

EMC03581 1152 DPV- - -AFLE- - -RKGYRN- -V- ^■QEENIIK- -LPKYSLFK- -LENGRKRLLAS ARELQKGNEIVLPNHLGTLLYHA 1214

WP 000428612 1187 SPI- - -AFLE- - -NKGYHN- -V- ^■RKENILC- -LPKYSLFE- -LKNGRRRMLAS AKELQKGNEIVLPVHLTTLLYHA 1249

WP 000428613 1185 NPI- - -TFLE- - -NKGYHN- -V- ^■RKENILC- -LPKYSLFE- -LENGRRRLLAS AKELQKGNEIVLPVYLTTLLYHS 1247

WP 049523028 1180 NPV- - -AFLE- - -GKGYQN- -V- ^■VEENIIR- -LPKYSLFE- -LENGRRRMLAS AKELQKGNEMVLPSYLIALLYHA 1242

WP 003107102 1146 DRI- - -TFLE- - -KKGYQD- -I- ^■QESLIIK- -LPKFSLFE- -LENGRKRLLAS —ELQKGNELSLPNKYIQFLYLA 1208

WP 054279288 1179 NPI- - -AFLE- - -SKGYHD- -I- ^■QEHLMIT- -LPKYSLFE- -LENGRRRLLAS —ELQKGNEMVLPQHLVTFLYRV 1241

WP 049531101 1189 NPT- - -AYLE- - -EYGYKN- -I- ^■NPNLIIK- -LPKYSLFK- -FNDGQRRLLAS SIELQKGNELILPYHFTTLLYHA 1251

WP 049538452 1189 NPI- - -AYLE- - -ECGYKN- -I- ^■NPNLIIK- -LPKYSLFE- -FNGGQRRLLAS SIELQKGNELILPYHFTALLYHT 1251

WP 049549711 1191 NPI- - -AYLE- - -ECGYKN- -I- ^■NPNLIIK- -LPKYSLFE- -FNGGQRRLLAS SIELQKGNELILPYHFTALLYHA 1253

WP 007896501 1183 DNI- - -AFLE- - -KKGYQD- -I- ^■QEKLLIK- -LPKYSLFE- -LENGRRRLLAS —EFQKGNELALSGKYMKFLYLA 1245

EFR44625 1135 DNI- - -AFLE- - -KKGYQD- -I- ^■QEKLLIK- -LPKYSLFE- -LENGRRRLLAS —EFQKGNELALSGKYMKFLYLA 1197

WP 002897477 1184 NPI- - -TFLE- - -NKGYHN- -V- ^■RKENILC- -LPKYSLFE- -LENGRRRLLAS AKELQKGNEIVLPVCLTTLLYHS 1246

WP 002906454 1190 NPV- - -TYLE- - -ECGYKN- -I- ^■NSNLIIK- -LPKYSLFE- -FNDGQRRLLAS SIELQKGNELILPYHLTALLYHA 1252

WP 009729476 1185 NPI- - -AFLE- - -NKGYHN- -V- ^■CKENILC- -LPKYSLFE- -LENGRRRLLAS AKELQKCNEIVLPVYLTTLLYHS 1247

CQR24647 1175 NSV- - -TFLE- - -EKGYRN- -I- ^■RENTIIK- -FPKYSLFE- -LENGRRRLLAS AIELQKGNEMFLPQQFVNLLYHA 1237

WP 000066813 1189 NPI- - -TFLE- - -NKGYHN- -V- ^■RKENILC- -LPKYSLFE- -LESGRRRMLAS AKELQKGNEIVLPVYLTTLLYHS 1251

WP 009754323 1185 NPI- - -TFLE- - -NKGYHN- -V- ^■RKENILC- -LPKYSLFE- -LENGRRRLLAS AKELQKGNEIVLPVYLTTLLYHS 1247

WP 044674937 1178 NPI- - -EFLE- - -HKGYKN- -I- ^■LEKNIIK- -LPKYSLFE- -LENGRRRLLAS AKELQKGNEMILPPHLVTLLYHS 1240

WP 044676715 1180 NPI- - -EFLE- - -HKGYKN- -I- ^■LEKNIIK- -LPKYSLFE- -LENGRRRLLAS AKELQKGNEMILPPHLVTLLYHS 1242

WP 044680361 1180 NPI- - -EFLE- - -HKGYKN- -I- ^■LEKNIIK- -LPKYSLFE- -LENGRRRLLAS AKELQKGNEMILPPHLVTLLYHS 1242

WP 044681799 1178 NPI- - -EFLE- - -HKGYKN- -I- ^■LEKNIIK- -LPKYSLFE- -LENGRRRLLAS AKELQKGNEMILPPHLVTLLYHS 1240

WP 049533112 1186 DKR- - -AFLL- - -GKGYKD- -I- ^■K—KIIE- -LPKYSLFE- -LKDGSRRMLAS RGEIHKGNELFVPQKFTTLLYHA 1253

WP 029090905 1118 SETslqAYIA- - -EQIKSE- -VelLN grlLKYQLIS- —NNGNRLYIAG -SERHNARQLIVSDEAAKVIWLI 1181

WP 006506696 1150 EKI- - -NYIE- -eKEGLSD- -VrllK Dn -IP QMIEm DGGEYLLTS —EYVNARQLVLNEKQCALIADI 1211

AIT42264 1177 NPI- - -DFLE- - -AKGYKE- -V- ^■KKDLIIK- -LPKYSLFE- -LENGRKRMLAS -GELQKGNELALPSKYVNFLYLA 1239

WP 034440723 1150 QTT- - -EYLG- - -KIGFNK- -AsIIN S- -FKNYTLFE- -LENGSRRMIVG KGELQKGNQMYLPQNLLEFVYHL 1217

AKQ21048 1177 NPI- - -DFLE- - -AKGYKE- -V- ^■KKDLIIK- -LPKYSLFE- -LENGRKRMLAS -GELQKGNELALPSKYVNFLYLA 1239

WP 004636532 1151 HPT- - -AYLE- - -EAGYNN- -P- ^■TV—LHE- -LFKYQLFE- -LEDGSRRMIAS AKEFQKGNQMVLPLELVELLYHA 1211

WP 002364836 1157 NPI- - -LFLE- - -EKGFLR- -P- ^■RV—LMK- -LPKYTLYE- -FPEGRRRLLAS AKEAQKGNQMVLPEHLLTLLYHA 1217

WP 016631044 1108 NPI- - -LFLE- - -EKGFLR- -P- ^■RV—LMK- -LPKYTLYE- -FPEGRRRLLAS AKEAQKGNQMVLPEHLLTLLYHA 1168

EMS75795 893 DPI- - -GFLS- - -NKGYSN- -V- ^■TKF—IK- -LSKYTLYE- -LENGRRRMVAS -KEAQKANSFILPEKLVTLLYHA 953

WP 002373311 1157 NPI- - -LFLE- - -EKGFLR- -P- ^■RV—LMK- -LPKYTLYE- -FPEGRRRLLAS AKEAQKGNQMVLPEHLLTLLYHA 1217

WP 002378009 1157 NPI- - -LFLE- - -EKGFLR- -p- ^■RV—LMK- -LPKYTLYQ- -FPEGRRRLLAS AKEAQKGNQMVLPEHLLTLLYHA 1217

WP 002407324 1157 NPI- - -LFLE- - -EKGFLR- -p- ^■RV—LMK- -LPKYTLYE- -FPEGRRRLLAS AKEAQKGNQMVLPEHLLTLLYHA 1217

WP 002413717 1157 NPI- - -LFLE- - -EKGFLR- -p- ^■RV—LMK- -LPKYTLYE- -FPEGRRRLLAS AKEAQKGNQMVLPEHLLTLLYHA 1217

WP 010775580 1159 NPI- - -LFLE- - -EKGFLR- -p- ^■RV—LMK- -LPKYTLYE- -FPEGRRRLLAS AKEAQKGNQMVLPEHLLTLLYHA 1219

WP 010818269 1157 NPI- - -LFLE- - -EKGFLR- -p- ^■RV—LMK- -LPKYTLYE- -FPEGRRRLLAS AKEAQKGNQMVLPEHLLTLLYHA 1217

WP 010824395 1157 NPI—-LFLE—-EKGFLR--P-RV--^■LMK—-LPKYTLYE- -FPEGRRRLLAS AKEAQKGNQMVLPEHLLTLLYHA 1217

WP 016622645 1157 NPI— -LFLE— -EKGFLR- -P-RV-- ^■LMK— -LPKYTLYE- -FPEGRRRLLAS AKEAQKGNQMVLPEHLLTLLYHA 1217

WP 033624816 1157 NPI— -LFLE— -EKGFLR- -P-RV-- ^■LMK— -LPKYTLYE- -FPEGRRRLLAS AKEAQKGNQMVLPERLLTLLYHA 1217

WP 033625576 1157 NPI— -LFLE— -EKGFLR- -P-RV-- ^■LMK— -LPKYTLYE- -FPEGRRRLLAS AKEAQKGNQMVLPEHLLTLLYHA 1217

WP 033789179 1157 NPI— -LFLE— -EKGFLR- -P-RV-- ^■LMK— -LPKYTLYE- -FPEGRRRLLAS AKEAQKGNQMVLPEHLLTLLYHA 1217

WP 002310644 1159 SPV— -LFLK— -NKGYEQ- -A-EIE- -MK— -LPKYALFE- -LENGRKRMVAS -KEAQKANSFLLPEHLVTLLYHA 1219

WP 002312694 1160 SPV— -LFLK— -NKGYEQ- -A-EIE- -MK— -LPKYALFE- -LENGRKRMVAS -KEAQKANSFLLPEHLVTLLYHA 1220

WP 002314015 1160 SPV— -LFLK— -NKGYEQ- -A-EIE- -MK— -LPKYALFE- -LENGRKRMVAS -KEAQKANSFLLPEHLVTLLYHA 1220

WP 002320716 1160 SPV— -LFLK— -NKGYEQ- -A-EIE- -MK— -LPKYALFE- -LENGRKRMVAS -KEAQKANSFLLPEHLVTLLYHA 1220

WP 002330729 1159 SPV— -LFLK— -NKGYEQ- -A-EIE- -MK— -LPKYALFE- -LENGRKRMVAS -KEAQKANSFLLPEHLVTLLYHA 1219

WP 002335161 1160 SPV— -LFLK— -NKGYEQ- -A-EIE- -MK— -LPKYALFE- -LENGRKRMVAS -KEAQKANSFLLPEHLVTLLYHA 1220

WP 002345439 1160 SPV— -LFLK— -NKGYEQ- -A-EIE- -MK— -LPKYALFE- -LENGRKRMVAS -KEAQKANSFLLPEHLVTLLYHA 1220

WP 034867970 1150 DPT— -TFLK— -EKGFPQ- -V-TEF- -IK— -LPKYTLFE- -FDNGRRRFLAS -KESQKGNPFILSDQLVTLLYHA 1210

WP 047937432 1160 SPV— -LFLK— -NKGYEQ- -A-EIE- -MK— -LPKYALFE- -LENGRKRMVAS -KEAQKANSFLLPEHLVTLLYHA 1220

WP 010720994 1150 DPT— -TFLK— -DKGFPQ- -V-TEF- -IK— -LPKYTLFE- -FDNGRRRFLAS -KESQKGNPFILSDQLVTLLYHA 1210

WP 010737004 1150 DPT— -TFLK— -EKGFPQ- -V-TEF- -IK— -LPKYTLFE- -FDNGRRRFLAS -KESQKGNPFILSDQLVTLLYHA 1210

WP 034700478 1150 DPT— -TFLK— -DKGFPH- -V-TEF- -IK— -LPKYTLFE- -FDNGRRRFLAS -KESQKGNPFILSDQLVTLLYHA 1210

WP 007209003 1148 NPI1- —YLS— -KKDYHN- —pKVEAI -LPKYSLFE- -FENGRRRMVAS -SETQKGNQLI I PGHLMELLYHS 1208

WP 023519017 1144 DPR— -EFLK— -TKGYEG- -V-KQW- -LI— -LPKYILFE- -AQGGYRRMIAS -QETQKANSLILPENLVTLLYHA 1204

WP 010770040 1155 DPV— -SLLE— -EKGYAN- -P-EV-- ^■LIH— -LPKYTLYE- -LENGRRRLLAS ANEAQKGNQLVLPASLVTLLYHA 1215

WP 048604708 1152 NER— -EFLK— -NKGYQN- -P-QI-- ^■CMK— -LPKYSLYE- -FDDGRRRLLAS AKEAQKGNQMVLPAHLVTFLYHA 1212

WP 010750235 1153 DPI— -SFLI— -EKGYSN- -V-NQF- -IK— -LPKYTLFE- -LANGQRRMLAS -QELQKANSFILPEKLVTLLYHA 1213

AII16583 1216 NPI— -DFLE— -AKGYKE- -V-KKDLIIK— -LPKYSLFE- -LENGRKRMLAS -GELQKGNELALPSKYVNFLYLA 1278

WP 029073316 1165 TKI— -NYIK—eSEGLEE- -VkllK- ^■—E— -ILKNQLIEi NGGLFYVTS —EIVNARQLILDFNCTRIIDGI 1225

WP 031589969 1165 IKI— -NYLK—qAEDLEE- -VqlGK- ^■—E— -ILKNQLIEk DGGLYYIVA —EIINAKQLILNESQTKLVCEI 1225

KDA45870 1139 DPT— -AYLA— -SRGYTNvtNsFIL- —PKYSLLEd —PEGRRRYLAS -KEFQKANELILPQHLVELLYWV 1199

WP 039099354 1171 QKI-spQFTKv- —KKQKGtiV-KWEDFEv- -IAPHILINq fFDNGQELTLGS HNEQELILDKTAVKLLNGA 1241

AKP02966 1173 KTL—qNWLE— -ENVKHKksIqllK- ^■—Nn- -VPIGQIIY SKKVGLLS -REIANRQQLILPPEHSALLRIL 1237

WP 010991369 1155 DEK— -AFLE— -EQGYRQ- -P-KV-- ^■LAK— -LPKYTLYE- -CEEGRRRMLAS ANEAQKGNQQVLPNHLVTLLHHA 1215

WP 033838504 1155 DEK— -AFLE— -EQGYRQ- -P-KV-- ^■LAK— -LPKYTLYE- -CEEGRRRMLAS ANEAQKGNQQVLPNHLVTLLHHV 1215

EHN60060 1158 DEK— -AFLE— -EQGYRQ- -P-KV-- ^■LAK— -LPKYTLYE- -CEEGRRRMLAS ANEAQKGNQQVLPNHLVTLLHHV 1218

EFR89594 924 DEK— -AFLE— -EQGYRQ- -P-KV-- ^■LAK— -LPKYTLYE- -CEEGRRRMLAS ANEAQKGNQQVLPNHLVTLLHHA 984

WP 038409211 1155 DQK— -AFLE— -EKGYYS- -P-KV-- ^■LTK— -IPKYTLYE- -CENGRRRMLGS ANEAQKGNQMVLPNHLMTLLYHA 1215

EFR95520 774 DQK— -AFLE— -EKGYYS- -P-KV-- ^■LTK— -IPKYTLYE- -CENGRRRMLGS ANEAQKGNQMVLPNHLMTLLYHA 834

WP 003723650 1155 DEE— -AFLE— -EKGYRH- -P-KV-- ^■LTK— -LPKYTLYE- -CEKGRRRMLAS ANEAQKGNQLVLSNHLVSLLYHA 1215

WP 003727705 1155 DEE— -AFLE— -EKGYHQ- -P-KV-- ^■LTK— -LPKYTLYE- -CEKGRRRMLSS ANEAQKGNQLVLSNHLVSLLYHA 1215

WP 003730785 1155 DEE— -AFLE— -EKGYHQ- -P-KV-- ^■LTK— -LPKYTLYE- -CEKGRRRMLSS ANEAQKGNQLVLSNHLVSLLYHA 1215

WP 003733029 1155 DEK— -TFLE— -EKGYHQ- -P-KV-- ^■LIK— -VPKYTLYE- -CKNGRRRMLGS ANEAHKGNQMLLPNHLMALLYHA 1215

WP 003739838 1155 DEK— -SFLE— -KQGYRQ- -P-KV-- ^■LTK— -LPKYTLYE- -CENGRRRMLAS ANEAQKGNQQVLKGQLITLLHHA 1215

WP 014601172 1155 DEE-—AFLE-—EKGYRH--P-^■KV—LTK--LPKYTLYE -CEKGRRRMLAS ANEAQKGNQLVLSNHLVSLLYHA 1215

WP 023548323 1155 DEK- —VFLE- —GKGYHQ- -P- ^■KV—LTK- -LPKYALYE -CENGRRRMLGS ANEVHKGNQMLLPNHLMTLLYHA 1215

WP 031665337 1155 DEE- —AFLE- —EKGYRH- -P- ^■KV—LTK- -LPKYTLYE -CEKGRRRMLAS ANEAQKGNQLVLSNHLVSLLYHA 1215

WP 031669209 1155 DEK- —TFLE- —EKGYHQ- -P- ^■KV—LIK- -VPKYTLYE -CENGRRRMLGS ANEAHKGNQMLLPNHLMALLYHA 1215

WP 033920898 1155 DEK- —VFLE- —GKGYHQ- -P- ^■KV—LTK- -LPKYALYE -CENGRRRMLGS ANEVHKGNQMLLPNHLMTLLYHA 1215

AKI42028 1158 DEE- —AFLE- —EKGYRH- -P- ^■KV—LTK- -LPKYTLYE -CEKGRRRMLAS ANEAQKGNQLVLSNHLVSLLYHA 1218

AKI50529 1158 DEK- —VFLE- —GKGYHQ- -P- ^■KV—LTK- -LPKYALYE -CENGRRRMLGS ANEVHKGNQMLLPNHLMTLLYHA 1218

EFR83390 603 DEE- —AFLE- —EKGYRH- -P- ^■KV—LTK- -LPKYTLYE -CEKGRRRMLAS ANEAQKGNQLVLSNHLVSLLYHA 663

WP 046323366 1155 DQK- —EFLE- —GKGYRN- -P- ^■KV—ITK- -IPKYTLYE -CENGRRRMLGS ANEAQKGNQMVLPNHLMTLLYHA 1215

AKE81011 1193 NPI- —DFLE- —AKGYKE- -V- ^■KKDLIIK- -LPKYSLFE -LENGRKRMLAS -GELQKGNELALPSKYVNFLYLA 1255

CU082355 1154 EQI- —EYVE- -kEEKLSD- -VkllK Nn -IPLNQLIE -—DGRQYLLTS —ECVNAMQLVLNEEQCKLIADI 1215

WP 033162887 1155 EQL- —SYIAspeHEDLID- -VrlVK E- -ILKNQLIE -—DGGLYYVTS —EYVTARQLSLNEQSCKLISEI 1217

AGZ 01981 1210 NPI- —DFLE- —AKGYKE- -V- ^■KKDLIIK- -LPKYSLFE -LENGRKRMLAS -GELQKGNELALPSKYVNFLYLA 1272

AKA60242 1177 NPI- —DFLE- —AKGYKE- -V- ^■KKDLIIK- -LPKYSLFE -LENGRKRMLAS -GELQKGNELALPSKYVNFLYLA 1239

AKS40380 1177 NPI- —DFLE- —AKGYKE- -V- ^■KKDLIIK- -LPKYSLFE -LENGRKRMLAS -GELQKGNELALPSKYVNFLYLA 1239

4UN5 B 1181 NPI- —DFLE- —AKGYKE- -V- ^■KKDLIIK- -LPKYSLFE -LENGRKRMLAS -GELQKGNELALPSKYVNFLYLA 1243

WP 010922251 1240 SHYEKLKgSPEDnEQKQL- FVEQHKHYLDEIIEQISEFSKRVILAD—ANLDKVL-S AYN-KH—-RDKPIREq- 1305

WP ^"039695303 1249 HRAD NFNS-TEYLN- YVSEHKKEFEKVLSCVEDFANLYVDVE—KNLSKIR-A VAD-SM— -DNFSIEE— 1308

WP ^"045635197 1247 KNVH KLDE-PGHLE- YIQKHRNEFKDLLNLVSEFSQKYVLAD—ANLEKIK-S LYA-DN— -EQADIEI— 1306

5AXW A 979 GELYRVIg NDlLNRIE- -VNMIDITYREYLENMNDKRPPRIIKTiaSKTQSIK-K LYEvKSk- -KHPQIIKkg 1056

WP 009880683 924 SHYEKLKgSPEDnEQKQL- FVEQHKHYLDEIIEQISEFSKRVILAD—ANLDKVL-S AYN-KH— -RDKPIREq- 989

WP ^"010922251 1240 SHYEKLKgSPEDnEQKQL- FVEQHKHYLDEIIEQISEFSKRVILAD—ANLDKVL-S AYN-KH— -RDKPIREq- 1305

WP ^"011054416 1240 SHYEKLKgSPEDnEQKQL- FVEQHKHYLDEIIEQISEFSKRVILAD—ANLDKVL-S AYN-KH— -RDKPIREq- 1305

WP ^"011284745 1240 SHYEKLKgSPEDnEQKQL- FVEQHKHYLDEIIEQISEFSKRVILAD—ANLDKVL-S AYN-KH— -RDKPIREq- 1305

WP ^"011285506 1240 SHYEKLKgSPEDnEQKQL- FVEQHKHYLDEIIEQISEFSKRVILAD—ANLDKVL-S AYN-KH— -RDKPIREq- 1305

WP ^"011527619 1240 SHYEKLKgSPEDnEQKQL- FVEQHKHYLDEIIEQISEFSKRVILAD—ANLDKVL-S AYN-KH— -RDKPIREq- 1305

WP ^"012560673 1240 SHYEKLKgSPEDnEQKQL- FVEQHKHYLDEIIEQISEFSKRVILAD—ANLDKVL-S AYN-KH— -RDKPIREq- 1305

WP ^"014407541 1239 SHYEKLKgSPEDnEQKQL- FVEQHKHYLDEIIEQISEFSKRVILAD—ANLDKVL-S AYN-KH— -RDKPIREq- 1304

WP ^"020905136 1240 SHYEKLKgSPEDnEQKQL- FVEQHKHYLDEIIEQISEFSKRVILAD—ANLDKVL-S AYN-KH— -RDKPIREq- 1305

WP ^"023080005 1239 SHYEKLKgSPEDnEQKQL- FVEQHKHYLDEIIEQISEFSKRVILAD—ANLDKVL-S AYN-KH— -RDKPIREq- 1304

WP ^"023610282 1239 SHYEKLKgSPEDnEQKQL- FVEQHKHYLDEIIEQISEFSKRVILAD—ANLDKVL-S AYN-KH— -RDKPIREq- 1304

WP ^"030125963 1240 SHYEKLKgSPEDnEQKQL- FVEQHKHYLDEIIEQISEFSKRVILAD—ANLDKVL-S AYN-KH— -RDKPIREq- 1305

WP ^"030126706 1240 SHYEKLKgSPEDnEQKQL- FVEQHKHYLDEIIEQISEFSKRVILAD—ANLDKVL-S AYN-KH— -RDKPIREq- 1305

WP ^"031488318 1240 SHYEKLKgSPEDnEQKQL- FVEQHKHYLDEIIEQISEFSKRVILAD—ANLDKVL-S AYN-KH— -RDKPIREq- 1305

WP ^"032460140 1240 SHYEKLKgSPEDnEQKQL- FVEQHKHYLDEIIEQISEFSKRVILAD—ANLDKVL-S AYN-KH— -RDKPIREq- 1305

WP ^"032461047 1240 SHYEKLKgSPEDnEQKQL- FVEQHKHYLDEIIEQISEFSKRVILAD—ANLDKVL-S AYN-KH— -RDKPIREq- 1305

WP ^"032462016 1240 SHYEKLKgSPEDnEQKQL- FVEQHKHYLDEIIEQISEFSKRVILAD—ANLDKVL-S AYN-KH— -RDKPIREq- 1305

WP ^"032462936 1240 SHYEKLKgSPEDnEQKQL- FVEQHKHYLDEIIEQISEFSKRVILAD—ANLDKVL-S AYN-KH— -RDKPIREq- 1305

WP ^"032464890 1240 SHYEKLKgSPEDnEQKQL- FVEQHKHYLDEIIEQISEFSKRVILAD—ANLDKVL-S AYN-KH— -RDKPIREq- 1305

WP ^"033888930 1065 SHYEKLKgSPEDnEQKQL- FVEQHKHYLDEIIEQISEFSKRVILAD—ANLDKVL-S AYN-KH— -RDKPIREq- 1130

WP ^"038431314 1240 SHYEKLKgSPEDnEQKQL- FVEQHKHYLDEIIEQISEFSKRVILAD—ANLDKVL-S AYN-KH— -RDKPIREq- 1305

WP ^"038432938 1239 SHYEKLKgSPEDnEQKQL- FVEQHKHYLDEIIEQISEFSKRVILAD—ANLDKVL-S AYN-KH— -RDKPIREq- 1304

WP ^"038434062 1240 SHYEKLKgSPEDnEQKQL- FVEQHKHYLDEIIEQISEFSKRVILAD—ANLDKVL-S AYN-KH— -RDKPIREq- 1305

BAQ51233 1151 SHYEKLKgSPEDnEQKQL- FVEQHKHYLDEIIEQISEFSKRVILAD—ANLDKVL-S AYN-KH— -RDKPIREq- 1216

KGE60162 415 SHYEKLKgSPEDnEQKQL- FVEQHKHYLDEIIEQISEFSKRVILAD—ANLDKVL-S AYN-KH— -RDKPIREq- 480

KGE60856 178 SHYEKLKgSPEDnEQKQL- FVEQHKHYLDEIIEQISEFSKRVILAD—ANLDKVL-S AYN-KH— -RDKPIREq- 243

WP 002989955 1240 SHYEKLKgSPEDnEQKQL- FVEQHKHYLDEIIEQISEFSKRVILAD—ANLDKVL-S AYN-KH— -RDKPIREq- 1305

WP ^"003030002 1222 YQIE KNYE-PEHRE- YVEKHKDEFKELLEYISVFSRKYVLAD—NNLTKIE-M LFS-KN— -KDAEVSS— 1281

WP ^"003065552 1250 QRIN SFNS-TKYLD- YVSAHKKEFEKVLSCVEDFANLYVDVE—KNLSKIR-A VAD-SM— -DNFSIEE— 1309

WP ^"001040076 1241 SRYNESKgKPEEiEKKQE- FVNQHVSYFDDI FQI INDFSKRVILAD—ANLEKIN-R LYQ-DNk- -ENIPVDE— 1306

WP ^"001040078 1249 SRYNESKgKPEEiEKKQE- FVNQHVSYFDDILQLINDFSKRVILAD—ANLEKIN-K LYQ-DNk- -ENISVDE— 1314

WP ^"001040080 1241 SRYNESKgKPEEiEKKQE- FVNQHVSYFDDILQLINDFSKRVILAD—ANLEKIN-K LYQ-DNk- -ENISVDE— 1306

WP ^"001040081 1241 SRYNESKgKPEEiEKKQE- FVNQHVSYFDDILQLINDFSKRVILAD—ANLEKIN-K LYQ-DNk- -ENISVDE— 1306

WP ^"001040083 1241 SRYNESKgKPEEiEKKQE- FVNQHVSYFDDILQLINDFSKRVILAD—ANLEKIN-K LYQ-DNk- -ENISVDE— 1306

WP ^"001040085 1241 SRYNESKgKPEEiEKKQE- FVNQHVSYFDDILQLINDFSKRVILAD—ANLEKIN-K LYQ-DNk- -ENISVDE— 1306

WP 001040087 1241 SRYNESKgKPEEiEKKQE--FVNQHVSYFDDILQLINDFSKRVILAD--ANLEKIN-^■K LYQ-^■DNk--ENISVDE— 1306

WP 001040088 1241 SRYNESKgKPEEiEKKQE- -FVNQHVSYFDDILQLINDFSKRVILAD- -ANLEKIN- ^■K LYQ- ^■DNk- -ENISVDE— 1306

WP 001040089 1241 SRYNESKgKPEEiEKKQE- -FVNQHVSYFDDILQLINDFSKRVILAD- -ANLEKIN- ^■K LYQ- ^■DNk- -ENISVDE— 1306

WP 001040090 1241 SRYNESKgKPEEiEKKQE- -FVNQHVSYFDDILQLINDFSKRVILAD- -ANLEKIN- ^■K LYQ- ^■DNk- -ENISVDE— 1306

WP 001040091 1241 SRYNESKgKPEEiEKKQE- -FVNQHVSYFDDILQLINDFSKRVILAD- -ANLEKIN- ^■K LYQ- ^■DNk- -ENISVDE— 1306

WP 001040092 1241 SRYNESKgKPEEiEKKQE- -FVNQHISYFDDILQLINDFSKRVILAD- -ANLEKIN- ^■K LYS- ^■DNk- -DNTPVDE— 1306

WP 001040094 1241 SRYNELKgKPEEiEQKQE- -FWQHVSYFDDILQIINDFSNRVILAD- -ANLEKIN- ^■K LYQ- ^■DNk- -ENIPVDE— 1306

WP 001040095 1241 SRYNELKgKPEEiEQKQE- -FWQHVSYFDDILQIINDFSNRVILAD- -ANLEKIN- ^■K LYQ- ^■DNk- -ENIPVDE— 1306

WP 001040096 1241 SRYNELKgKPEEiEQKQE- -FWQHVSYFDDILQIINDFSNRVILAD- -ANLEKIN- ^■K LYQ- ^■DNk- -ENIPVDE— 1306

WP 001040097 1241 SRYNELKgKPEEiEQKQE- -FWQHVSYFDDILQIINDFSNRVILAD- -ANLEKIN- ^■K LYQ- ^■DNk- -ENIPVDE— 1306

WP 001040098 1241 SRYNELKgKPEEiEQKQE- -FWQHVSYFDDILQIINDFSNRVILAD- -ANLEKIN- ^■K LYQ- ^■DNk- -ENIPVDE— 1306

WP 001040099 1241 SRYNELKgKPEEiEQKQE- -FWQHVSYFDDILQIINDFSNRVILAD- -ANLEKIN- ^■K LYQ- ^■DNk- -ENIPVDE— 1306

WP 001040100 1241 SRYNELKgKPEEiEQKQE- -FWQHVSYFDDILQIINDFSNRVILAD- -ANLEKIN- ^■K LYQ- ^■DNk- -ENIPVDE— 1306

WP 001040104 1241 SRYNESKgKPEEiEKKQE- -FVNQHVSYFDDILQLINDFSKRVILAD- -ANLEKIN- ^■K LYQ- ^■DNk- -ENISVDE— 1306

WP 001040105 1241 SRYNESKgKPEEiEKKQE- -F QHVSYFDDILQLINDFSKRVILAD- -ANLEKIN- ^■K LYQ- ^■DNk- -ENISVDE— 1306

WP 001040106 1241 SRYNELKgKPEEiEQKQE- -FWQHVSYFDDILQIINDFSNRVILAD- -ANLEKIN- ^■K LYQ- ^■DNk- -ENISVDE— 1306

WP 001040107 1241 SRYNELKgKPEEiEQKQE- -FWQHVSYFDDILQIINDFSNRVILAD- -ANLEKIN- ^■K LYQ- ^■DNk- -ENISVDE— 1306

WP 001040108 1241 SRYNELKgKPEEiEQKQE- -FWQHVSYFDDILQIINDFSNRVILAD- -ANLEKIN- ^■K LYQ- ^■DNk- -ENISVDE— 1306

WP 001040109 1241 SRYNELKgKPEEiEQKQE- -FWQHVSYFDDILQIINDFSNRVILAD- -ANLEKIN- ^■K LYQ- ^■DNk- -ENISVDE— 1306

WP 001040110 1241 SRYNELKgKPEEiEQKQE- -FWQHVSYFDDILQIINDFSNRVILAD- -ANLEKIN- ^■K LYQ- ^■DNk- -ENISVDE— 1306

WP 015058523 1241 SRYNESKgKPEEiEKKQE- -FVNQHVSYFDDILQLINDFSKRVILAD- -ANLEKIN- ^■K LYS- ^■DNk- -DNTPVDE— 1306

WP 017643650 1241 SRYNELKgKPEEiEQKQE- -FWQHVSYFDDILQIINDFSNRVILAD- -ANLEKIN- ^■K LYQ- ^■DNk- -ENIPVDE— 1306

WP 017647151 1241 SRYNELKgKPEEiEQKQE- -FWQHVSYFDDILQIINDFSNRVILAD- -ANLEKIN- ^■K LYQ- ^■DNk- -ENISVDE— 1306

WP 017648376 1241 SRYNELKgKPEEiEQKQE- -FWQHVSYFDDILQIINDFSNRVILAD- -ANLEKIN- ^■K LYQ- ^■DNk- -ENISVDE— 1306

WP 017649527 1241 SRYNESKgKPEEiEKKQE- -F QHVSYFDDILQLINDFSKRVILAD- -ANLEKIN- ^■K LYQ- ^■DNk- -ENISVDE— 1306

WP 017771611 1241 SRYNELKgKPEEiEQKQE- -FWQHVSYFDDILQIINDFSNRVILAD- -ANLEKIN- ^■K LYQ- ^■DNk- -ENISVDE— 1306

WP 017771984 1241 SRYNESKgKPEEiEKKQE- -F QHVSYFDDILQLINDFSKRVILAD- -ANLEKIN- ^■K LYQ- ^■DNk- -ENISVDE— 1306

CFQ25032 1241 SRYNESKgKPEEiEKKQE- -F QHVSYFDDILQLINDFSKRVILAD- -ANLEKIN- ^■K LYQ- ^■DNk- -ENISVDE— 1306

CFV16040 1241 SRYNESKgKPEEiEKKQE- -F QHVSYFDDILQLINDFSKRVILAD- -ANLEKIN- ^■K LYQ- ^■DNk- -ENISVDE— 1306

KLJ37842 1241 SRYNESKgKPEEiEKKQE- -F QHVSYFDDILQLINDFSKRVILAD- -ANLEKIN- ^■K LYQ- ^■DNk- -ENISVDE— 1306

KLJ72361 1241 SRYNESKgKPEEiEKKQE- -FVNQHVSYFDDILQLINDFSKRVILAD- -ANLEKIN- ^■K LYQ- ^■DNk- -ENISVDE— 1306

KLL20707 1255 SRYNESKgKPEEiEKKQE- -F QHVSYFDDILQLINDFSKRVILAD- -ANLEKIN- ^■K LYQ- ^■DNk- -ENISVDE— 1320

KLL42645 1241 SRYNELKgKPEEiEQKQE- -FWQHVSYFDDILQIINDFSNRVILAD- -ANLEKIN- ^■K LYQ- ^■DNk- -ENISVDE— 1306

WP 047207273 1241 SRYNESKgKPEEiEKKQE- -F QHVSYFDDILQLINDFSKRVILAD- -ANLEKIN- ^■K LYQ- ^■DNk- -ENISVDE— 1306

WP 047209694 1241 SRYNELKgKPEEiEQKQE- -FWQHVSYFDDILQIINDFSNRVILAD- -ANLEKIN- ^■K LYQ- ^■DNk- -ENIPVDE— 1306

WP 050198062 1241 SRYNESKgKPEEiEKKQE- -FVNQHVSYFDDILQLINDFSKRVILAD- -ANLEKIN- ^■K LYQ- ^■DNk- -ENISVDE— 1306

WP 050201642 1241 SRYNESKgKPEEiEKKQE- -F QHVSYFDDILQLINDFSKRVILAD- -ANLEKIN- ^■K LYQ- ^■DNk- -ENISVDE— 1306

WP 050204027 1241 SRYNELKgKPEEiEQKQE- -FWQHVSYFDDILQIINDFSNRVILAD- -ANLEKIN- ^■K LYQ- ^■DNk- -ENISVDE— 1306

WP 050881965 1241 SRYNESKgKPEEiEKKQE- -F QHVSYFDDILQLINDFSKRVILAD- -ANLEKIN- ^■K LYQ- ^■DNk- -ENISVDE— 1306

WP 050886065 1241 SRYNESKgKPEEiEKKQE--FVNQHVSYFDDILQLINDFSKRVILAD--ANLEKIN--K LYQ-^■DNk--ENISVDE— 1306

AHN30376 1241 SRYNESKgKPEEiEKKQE- -FVNQHVSYFDDILQLINDFSKRVILAD- -ANLEKIN- -K LYS- ^■DNk- -DNTPVDE— 1306

EA078426 1241 SRYNESKgKPEEiEKKQE- -FVNQHVSYFDDILQLINDFSKRVILAD- -ANLEKIN- -K LYQ- ^■DNk- -ENISVDE— 1306

CCW42055 1241 SRYNESKgKPEEiEKKQE- -FVNQHVSYFDDILQIINDFSNRVILAD- -ANLEKIN- -K LYQ- ^■DNk- -ENISVDE— 1306

WP 003041502 1254 KRIN NPIN-KDHIE- -YVKKHRDDFKELLNYVLEFNEKYVGAT- -KNGERLK- -E AVA- ^■DF— -DSKSNEE— 1313

WP 037593752 1223 YQIE KNYE-PEHRE- -YVEKHKDEFKELLEYISVFSRKYVLAD- -NNLTKIE- -M LFS- ^■KN— -KDAEVSS— 1282

WP 049516684 1223 YRIE KDYE-PEHRE- -YVEKHKDEFKELLEYISVFSRKYVLAD- -NNLTKIE- -M LFS- ^■KN— -KDAEVSS— 1282

GAD46167 1222 YQIE KNYE-PEHRE- -YVEKHKDEFKELLEYISVFSRKYVLAD- -NNLTKIE- -M LFS- ^■KN— -KDAEVSS— 1281

WP 018363470 1254 HRIG NFNS-AEHLK- -YVSEHKKEFEEVLSCVENFANVYVDVE- -KNLSKIR- -A AAD- ^■SM— -DNFSIEE— 1313

WP 003043819 1249 -KVNSNLK- -s SFD- ^■EQfavSDSIL—1- 1310

WP 006269658 1222 YRIE KDYE-PEHRE- -YVEKHKDEFKELLEYISVFSRKYVLAD- -NNLTKIE- -M LFS- ^■KN— -KDAEVSS— 1281

WP 048800889 1242 HRID NSDN-SEHLK- -YITEHKEEFGKLLSYIENFAKSYVDVD- -KNLEKIQ- -L AVE- ^■KI— -DSFSVKE— 1301

WP 012767106 1246 -HAHKIEsSKE—LEHEA- -YILDHYNDLYQLLSYIERFASLYVDVE- -KNISKVK- -E LFS- ^■NI— -ESYSISEi- 1308

WP 014612333 1246 -HAHKIEsSKE—LEHEA- -YILDHYNDLYQLLSYIERFASLYVDVE- -KNISKVK- -E LFS- ^■NI— -ESYSISEi- 1308

WP 015017095 1246 -HAHKIEsSKE—LEHEA- -YILDHYNDLYQLLSYIERFASLYVDVE- -KNISKVK- -E LFS- ^■NI— -ESYSISEi- 1308

WP 015057649 1246 -HAHKIEsSKE—LEHEA- -YILDHYNDLYQLLSYIERFASLYVDVE- -KNISKVK- -E LFS- ^■NI— -ESYSISEi- 1308

WP 048327215 1246 -HAHKIEsSKE—LEHEA- -YILDHYNDLYQLLSYIERFASLYVDVE- -KNISKVK- -E LFS- ^■NI— -ESYSISEi- 1308

WP 049519324 1246 -HAHKIEsSKE—LEHEA- -YILDHYNDLYQLLSYIERFASLYVDVE- -KNISKVK- -E LFS- ^■NI— -ESYSISEi- 1308

WP 012515931 1220 AHYHELTgSSEDvLRKKY- -FVDRHLHYFDDIIQMINDFAERHILAS- -SNLEKIN- -H TYH- ^■NN— -SDLPVNEr- 1285

WP 021320964 1220 AHYHELTgSSEDvLRKKY- -FVERHLHYFDDIIQMINDFAERHILAS- -SNLEKIN- -H TYH- ^■NN— -SDLPINEr- 1285

WP 037581760 1220 AHYHELTgSSEDvLRKKY- -FVERHLHYFDDIIQMINDFAERHILAS- -SNLEKIN- -H TYH- ^■NN— -SDLPVNEr- 1285

WP 004232481 1252 QHVN NSHK-PEHLN- -YVKQHKDEFKDIFNLIISIARINILKP- -KWDNL-- -IN- ^■EF— -TEYGQED— 1308

WP 009854540 1247 HRAD NFNS-TEYLN- -YVSEHKKEFEKVLSCVEDFANLYVDVE- -KNLSKIR- -A VAD- ^■SM— -DNFSIEE— 1306

WP 012962174 1248 HRVN SFNN-SEHLK- -YVSEHKKEFGEVLSCVENFAKSYVDVE- -KNLGKIR- -A VAD- ^■KI— -DTFSIED— 1307

WP 039695303 1249 HRAD NFNS-TEYLN- -YVSEHKKEFEKVLSCVEDFANLYVDVE- -KNLSKIR- -A VAD- ^■SM— -DNFSIEE— 1308

WP 014334983 1252 HRID SFNS-TEHLK- -YVSEHKKEFEKVLSCVENFSNLYVDVE- -KNLSKVR- -A AAE- ^■SM— -TNFSLEE— 1311

WP 003099269 1240 SHYTKFTgKEEDrEKKRS- -YVESHLYYFDEIMQIIVEYSNRYILAD- -SNLIKIQ- -N LYK- ^■EKd- —NFSIEEq- 1305

AHY15608 1240 SHYTKFTgKEEDrEKKRS- ΤΛζ T 1273

AHY17476 1240 SHYTKFTgKEEDrEKKRS- 1267

ESR09100 72 SHYTKFTgKEEDrEKKRS- -YVESHLYYFDEIMQIIVEYSNRYILAD- -SNLIKIQ- -N LYK- -Ek- -DNFSIEEq- 137

AGM98575 1240 SHYTKFTgKEEDrEKKRS- 1 ^~W 1281

ALF27331 1222 KNIH KVDE-PKHLD- -YVKKHKDEFKELLDWSNFSKKNILAE- -SNLEKIE- -E LYA- ^■QN— -NNKDITE— 1281

WP 018372492 1229 KKVDVLVkSKDD DYD- —LEEHRAEFAELLDCIKKFNDMYILAS- -SNMSKIE- -E IYQ- ^■KNi- —DAPIEE— 1289

WP 045618028 1252 QRIN KISE-PIHKQ- -YVETHQSEFKELLTAIISLSKKYI-QK- -PNVESL-- LQQ- ^■AF— -DQSDKDIyq 1310

WP 045635197 1247 KNVH KLDE-PGHLE- -YIQKHRNEFKDLLNLVSEFSQKYVLAD- -ANLEKIK- -s LYA- ^■DN— -EQADIEI— 1306

WP 002263549 1222 KNIH KVDE-PKHLD- -YVDKHKDEFKELLDWSNFSKKYTLAE- -GNLEKIK- -E LYA- ^■QN— -NGEDLKE— 1281

WP 002263887 1222 KNIH KVDE-PKHLD- -YVDKHKDEFKELLDWSNFSKKYTLAE- -GNLEKIK- -E LYA- ^■QN— -NGEDLKE— 1281

WP 002264920 1222 KNIH KVDE-PKHLD- -YVDKHKDEFKELLDWSNFSKKYTLAE- -GNLEKIK- -E LYA- ^■QN— -NGEDLKE— 1281

WP 002269043 1222 KNIH KVDE-PKHLD- -YVDKHKDEFKELLDWSNFSKKYTLAE- -GNLEKIK- -E LYA- ^■QN— -NGEDLKE— 1281

WP 002269448 1222 KNIH-—-KVDE- PKHLD--YVDKHKDEFKELLDWSNFSKKYTLAE--GNLEKIK-^■E LYA-QN---NGEDLKE-- 1281

WP ^"002271977 1222 KNIH- — -KVDE- PKHLD- -YVDKHKDEFKELLDWSNFSKKYTLAE- -GNLEKIK- ^■E LYA-QN- - -NGEDLKE- - 12 81

WP ^"002272766 1222 KNIH- — -KVDE- PKHLD- -YVDKHKDEFKELLDWSNFSKKYTLAE- -GNLEKIK- ^■E LYA-QN- - -NGEDLKE- - 12 81

WP ^"002273241 1222 KNIH- — -KVDE- PKHLD- -YVDKHKDEFKELLDWSNFSKKYTLAE- -GNLEKIK- ^■E LYA-QN- - -NGEDLKE- - 12 81

WP ^"002275430 1222 KNIH- — -KVDE- PKHLD- -YVDKHKDEFKELLDWSNFSKKYTLAE- -GNLEKIK- ^■E LYA-QN- - -NGEDLKE- - 12 81

WP ^"002276448 1222 KNIH- — -KVDE- PKHLD- -YVDKHKDEFKELLDWSNFSKKYTLAE- -GNLEKIK- ^■E LYA-QN- - -NGEDLKE- - 12 81

WP ^"002277050 1230 HHL— DN- DYSNE- -YVKNHYQQFDILFNEITSFSKKCKLGK- -EHIQKIE- ^■E AYSkER- - -DSASIEE- - 12 87

WP ^"002277364 1222 KNIH- — -KVDE- PKHLD- -YVDKHKDEFKELLDWSNFSKKYTLAE- -GNLEKIK- ^■E LYA-QN- - -NGEDLKE- - 12 81

WP ^"002279025 1222 KNIH- — -KVDE- PKHLD- -YVDKHKDEFKELLDWSNFSKKYTLAE- -GNLEKIK- ^■E LYA-QN- - -NGEDLKE- - 12 81

WP ^"002279859 1222 KNIH- — -KVDE- PKHLD- -YVDKHKDEFKELLDWSNFSKKYTLAE- -GNLEKIK- ^■E LYA-QN- - -NGEDLKE- - 12 81

WP ^"002280230 1222 KNIH- — -KVDE- PKHLD- -YVDKHKDEFKELLDWSNFSKKYTLAE- -GNLEKIK- ^■E LYA-QN- - -NGEDLKE- - 12 81

WP ^"002281696 1222 KNIH- — -KVDE- PKHLD- -YVDKHKDEFKELLDWSNFSKKYTLAE- -GNLEKIK- ^■E LYA-QN- - -NGEDLKE- - 12 81

WP ^"002282247 1230 HHL— DN- DYSNE- -YVKNHYQQFDILFNEITSFSKKCKLGK- -EHIQKIE- ^■E AYSkER- - -DFASIEE- - 12 87

WP ^"002282906 1222 KNIH- — -KVDE- PKHLD- -YVDKHKDEFKELLDWSNFSKKYTLAE- -GNLEKIK- ^■E LYA-QN- - -NGEDLKE- - 12 81

WP ^"002283846 1222 KNIH- — -KVDE- PKHLD- -YVDKHKDEFKELLDWSNFSKKYTLAE- -GNLEKIK- ^■E LYA-QN- - -NGEDLKE- - 12 81

WP ^"002287255 1222 KNIH- — -KVDE- PKHLD- -YVDKHKDEFKELLDWSNFSKKYTLAE- -GNLEKIK- ^■E LYA-QN- - -NGEDLKE- - 12 81

WP ^"002288990 1222 KNIH- — -KVDE- PKHLD- -YVDKHKDEFKELLDWSNFSKKYTLAE- -GNLEKIK- ^■E LYA-QN- - -NGEDLKE- - 12 81

WP ^"002289641 1222 KNIH- — -KVDE- PKHLD- -YVDKHKDEFKELLDWSNFSKKYTLAE- -GNLEKIK- ^■E LYA-QN- - -NGEDLKE- - 12 81

WP ^"002290427 1222 KNIH- — -KVDE- PKHLD- -YVDKHKDEFKELLDWSNFSKKYTLAE- -GNLEKIK- ^■E LYA-QN- - -NGEDLKE- - 12 81

WP ^"002295753 1222 KNIH- — -KVDE- PKHLD- -YVDKHKDEFKELLDWSNFSKKYTLAE- -GNLEKIK- ^■E LYA-QN- - -NGEDLKE- - 12 81

WP ^"002296423 1222 KNIH- — -KVDE- PKHLD- -YVDKHKDEFKELLDWSNFSKKYTLAE- -GNLEKIK- ^■E LYA-QN- - -NGEDLKE- - 12 81

WP ^"002304487 1236 KNIH- — -KVDE- PKHLD- -YVDKHKDEFKELLDWSNFSKKYTLAE- -GNLEKIK- ^■E LYA-QN- - -NGEDLKE- - 12 95

WP ^"002305844 1222 KNIH- — -KVDE- PKHLD- -YVDKHKDEFKELLDWSNFSKKYTLAE- -GNLEKIK- ^■E LYA-QN- - -NGEDLKE- - 12 81

WP ^"002307203 1222 KNIH- — -KVDE- PKHLD- -YVDKHKDEFKELLDWSNFSKKYTLAE- -GNLEKIK- ^■E LYA-QN- - -NGEDLKE- - 12 81

WP ^"002310390 1222 KNIH- — -KVDE- PKHLD- -YVDKHKDEFKELLDWSNFSKKYTLAE- -GNLEKIK- ^■E LYA-QN- - -NGEDLKE- - 12 81

WP ^"002352408 1222 KNIH- — -KVDE- PKHLD- -YVDKHKDEFKELLDWSNFSKKYTLAE- -GNLEKIK- ^■E LYA-QN- - -NGEDLKE- - 12 81

WP ^"012997688 1222 KNIH- — -KVDE- PKHLD- -YVDKHKDEFKELLDWSNFSKKYTLAE- -GNLEKIK- ^■E LYA-QN- - -NGEDLKE- - 12 81

WP ^"014677909 1222 KNIH- — -KVDE- PKHLD- -YVDKHKDEFKELLDWSNFSKKYTLAE- -GNLEKIK- ^■E LYA-QN- - -NGEDLKE- - 12 81

WP ^"019312892 1222 KNIH- — -KVDE- PKHLD- -YVDKHKDEFKELLDWSNFSKKYTLAE- -GNLEKIK- ^■E LYA-QN- - -NGEDLKE- - 12 81

WP ^"019313659 1222 KNIH- — -KVDE- PKHLD- -YVDKHKDEFKELLDWSNFSKKYTLAE- -GNLEKIK- ^■E LYA-QN- - -NGEDLKE- - 12 81

WP ^"019314093 1222 KNIH- — -KVDE- PKHLD- -YVDKHKDEFKELLDWSNFSKKYTLAE- -GNLEKIK- ^■E LYA-QN- - -NGEDLKE- - 12 81

WP ^"019315370 1222 KNIH- — -KVDE- PKHLD- -YVDKHKDEFKELLDWSNFSKKYTLAE- -GNLEKIK- ^■E LYA-QN- - -NGEDLKE- - 12 81

WP ^"019803776 1222 KNIH- — -KVDE- PKHLD- -YVDKHKDEFKELLDWSNFSKKYTLAE- -GNLEKIK- ^■E LYA-QN- - -NGEDLKE- - 12 81

WP ^"019805234 1222 KNIH- — -KVDE- PKHLD- -YVDKHKDEFKELLDWSNFSKKYTLAE- -GNLEKIK- ^■E LYA-QN- - -NGEDLKE- - 12 81

WP ^"024783594 1222 KNIH- — -KVDE- PKHLD- -YVDKHKDEFKELLDWSNFSKKYTLAE- -GNLEKIK- ^■E LYA-QN- - -NGEDLKE- - 12 81

WP ^"024784288 1230 HHL— DN- DYSNE- -YVKNHYQQFDILFNEITSFSKKCKLGK- -EHIQKIE- ^■E AYSkER- - -DFASIEE- - 12 87

WP ^"024784666 1222 KNIH- — -KVDE- PKHLD- -YVDKHKDEFKELLDWSNFSKKYTLAE- -GNLEKIK- ^■E LYA-QN- - -NGEDLKE- - 12 81

WP ^"024784894 1222 KNIH- — -KVDE- PKHLD- -YVDKHKDEFKELLDWSNFSKKYTLAE- -GNLEKIK- ^■E LYA-QN- - -NGEDLKE- - 12 81

WP ^"024786433 1230 HHL— DN- DYSNE- -YVKNHYQQFDILFNEITSFSKKCKLGK- -EHIQKIE- ^■E AYSkER- - -DSASIEE- - 12 87

WP 049473442 1222 KNIH -KVDE- PKHLD--YVDKHKDEFKELLDWSNFSKKYTLAE--GNLEKIK-^■E LYA--QN---NGEDLKE— 1281

WP ^"049474547 1222 KNIH -KVDE- PKHLD- -YVDKHKDEFKELLDWSNFSKKYTLAE- -GNLEKIK- ^■E LYA- -QN- - -NGEDLKE— 1281

EMC03581 1215 KNIH -KVDE- PKHLD- -YVDKHKDEFKELLDWSNFSKKYTLAE- -GNLEKIK- ^■E LYA- -QN- - -NGEDLKE— 1274

WP 000428612 1250 KNIH -RLDE- PEHLE- -YIQKHRNEFKGLLNLVSEFSQKYVLAD- -ANLEKIK- ^■N LYA- -DN- - -EQADIEI— 1309

WP ^"000428613 1248 KNVH -KLDE- PEHLE- -YIQKHRNEFKDLLNLVSEFSQKYVLAD- -ANLEKIQ- ^■N LYA- -DN- - -EQADIEI— 1307

WP ^"049523028 1243 KRIQ -KKDE- PEHLE- -YIKQHHSEFNDLLNFVSEFSQKYVLAE- -SNLEKIK- ^■N LYI- -DN- - -EQTNMEE— 1302

WP ^"003107102 1209 SRYTSFSgKEEDr 'EKHRH- -FVESHLHYFDEIKDIIADFSRRYILAD- -ANLEKIL- ^■T LYN- -EKn - —QFSIEEq- 1274

WP ^"054279288 1242 SKRDK—gTQSEnME -YISNHKEKFIEIFHYIIRYAEKNVIKP- -KVIERLN- ^■D TFNqKF- - -NDSDLTE1- 1303

WP ^"049531101 1252 QRIN -KISE- PIHKQ- -YVETHQSEFEELLTTIISLSKKYI-QK- -PIVESL-- ^■- LQQ- -AF- - -EQADKDIyq 1310

WP ^"049538452 1252 QRIN -KISE- PIHKQ- -YVEAHQNEFKELLTTIISLSKKYI-QK- -PNVESL-- ^■- LQQ- -AF- - -EQADKDIyq 1310

WP ^"049549711 1254 QRIN -KFSE- PIHKQ- -YVEAHQNEFKELLTIIISLSKKYI-QK- -PNVESL-- ^■- LHQ- -AF- - -EQADNDIyq 1312

WP ^"007896501 1246 SRYDKLSsKIESeQQKKL- -FVEQHLHYFDEILDIWKHATCYIKAE- -NNLKKII- ^■s LYK- -KK- - -EAYSINEq- 1311

EFR44625 1198 SRYDKLSsKIESeiQQKKL- -FVEQHLHYFDEILDIWKHATCYIKAE- -NNLKKII- ^■s LYK- -KK- - -EAYSINEq- 1263

WP 002897477 1247 KNLH -KLDE- PEHLE- -YIQKHRNEFKDLLNLVSEFSQKYILAE- -ANLEKIK- ^■D LYA- -DN- - -EQADIEI— 1306

WP ^"002906454 1253 QRIN -KISE- PIHKQ- -YVEAHQNEFKELLTTIISLSKKYI-QK- -PNVELL-- ^■- LQQ- -AF- - -DQADKDIyq 1311

WP ^"009729476 1248 KNVH -KLDE- PGHLE- -YIQKHRNEFKDLLNLVSEFSQKYVLAD- -ANLEKIK- ^■N LYA- -DN- - -EQADIEI— 1307

CQR24647 1238 QHAN -KEDS- VI- -YLEKHRHELSELFHHIIGVSEKTILKP- -KVEMTLN- ^■E AFE- -KHf - -EFDEVSE— 1295

WP 000066813 1252 KNVH -KLDE- PEHLE- -YIQKHRYEFKDLLNLVSEFSQKYVLAD- -ANLEKIK- ^■N LYA- -DN- - -EQADIEI— 1311

WP ^"009754323 1248 KNVH -KLDE- PEHLE- -YIQKHRYEFKDLLNLVSEFSQKYVLAE- -ANLEKIK- ^■s LYV- -DN- - -EQADIEI— 1307

WP ^"044674937 1241 SNIH -KITE- PIHLN- -YVNKNKHEFKELLRHISDFSTRYILAQ- -DRLSKIE- ^■E LYD- -KN- - -DGDDISD— 1300

WP ^"044676715 1243 SNIH -KITE- PIHLN- -YVNKNKHEFKELLRHISDFSTRYILAQ- -DRLSKIE- ^■E LYD- -KN- - -DGDDISD— 1302

WP ^"044680361 1243 SNIH -KITE- PIHLN- -YVNKNKHEFKELLRHISDFSTRYILAQ- -DRLSKIE- ^■E LYD- -KN- - -DGDDISD— 1302

WP ^"044681799 1241 SNIH -KITE- PIHLN- -YVNKNKHEFKELLRHISDFSTRYILAQ- -DRLSKIE- ^■E LYD- -KN- - -DGDDISD— 1300

WP ^"049533112 1254 KRIN -NPIN- KDHIE- -YVKKHRDDFKELLNYVLEFNEKYVGAT- -KNGERLK- ^■E AVA- -DF- - -DSKSNEE— 1313

WP ^"029090905 1182 STKQA— DE- AMFLKyyRLEHLEAVFEEL IRKQAADYQI FE- -KLIKKIEvN FYS- c TYNEk- 1240

WP ^"006506696 1212 YNAIYKQ -DYDNlDDILMi QLYIELTNKMKVLYPAY-rGIAEKFE- ^■s YW- i SKEEk- 1268

AIT42264 1240 SHYEKLKgSPEDnEQKQL- -FVEQHKHYLDEIIEQISEFSKRVILAD- -ANLDKVL- ^■s AYN- -KH- - -RDKPIREq- 1305

WP 034440723 1218 KHYNE— DE- -TSHK- -FIVEHKAYFDELLNYIVEFANKYLELE- -NSIEKIK- ^■D LYH- gKGPDVEEke 1276

AKQ21048 1240 SHYEKLKgSPEDnEQKQL- -FVEQHKHYLDEIIEQISEFSKRVILAD- -ANLDKVL- ^■s AYN- -KH- - -RDKPIREq- 1305

WP 004636532 1212 NRYDKVK fPDSIE- -YVHDNLAKFDDLLEYVIDFSNKYINAD- -KNVQKIQ- ^■K IYK- -EH- - -GTEDVEL— 1271

WP ^"002364836 1218 KQCLL— —PNQ- SESLA- -YVEQHQPEFQEILERWDFAEVHTLAK- -SKVQQIV- ^■K LFE- -AN- - -QTADVKE— 1277

WP ^"016631044 1169 KQCLL— —PNQ- SESLA- -YVEQHQPEFQEILERWDFAEVHTLAK- -SKVQQIV- ^■K LFE- -AN- - -QTADVKE— 1228

EMS75795 954 QHYDEIAhKESF- D- -YVNDHLSEFREILDQVIDFSNRYTIAA- -KNTEKIA- ^■E LFE- -QN- - -QESTVQS— 1013

WP 002373311 1218 KQCLL— —PNQ- SESLA- -YVEQHQPEFQEILERWDFAEVHTLAK- -SKVQQIV- ^■K LFE- -AN- - -QTADVKE— 1277

WP ^"002378009 1218 KQCLL— —PNQ- SESLA- -YVEQHQPEFQEILERWDFAEVHTLAK- -SKVQQIV- ^■K LFE- -AN- - -QTADVKE— 1277

WP ^"002407324 1218 KQCLL— —PNQ- SESLA- -YVEQHQPEFQEILERWDFAEVHTLAK- -SKVQQIV- ^■K LFE- -AN- - -QTADVKE— 1277

WP ^"002413717 1218 KQCLL— —PNQ- SESLA- -YVEQHQPEFQEILERWDFAEVHTLAK- -SKVQQIV- ^■K LFE- -AN- - -QTADVKE— 1277

WP ^"010775580 1220 KQCLL— —PNQ- SESLA- -YVEQHQPEFQEILERWDFAEVHTLAK- -SKVQQIV- ^■K LFE- -AN- - -QTADVKE— 1279

WP ^"010818269 1218 KQCLL— —PNQ- SESLA- -YVEQHQPEFQEILERWDFAEVHTLAK- -SKVQQIV- ^■K LFE- -AN- - -QTADVKE— 1277

WP_010824395 1218 KQCLL-- PNQ- SESLA YVEQHQPEFQEILERWDFAEVHTLAK--SKVQQIV--K LFE-^■AN—-QTADVKE— 1277 WP_016622645 1218 KQCLL-- PNQ- SESLA YVEQHQPEFQEILERWDFAEVHTLAK- -SKVQQIV- -K LFE- ^■AN— -QTADVKE— 1277 WP_033624816 1218 KQCLL-- PNQ- SESLA YVEQHQPEFQEILERWDFAEVHTLAK- -SKVQQIV- -K LFE- ^■AN— -QTADVKE— 1277 WP_033625576 1218 KQCLL-- PNQ- SESLA YVEQHQPEFQEILERWDFAEVHTLAK- -SKVQQIV- -K LFE- ^■TN— -QTADVKE— 1277 WP_033789179 1218 KQCLL-- PNQ- SESLA YVEQHQPEFQEILERWDFAEVHTLAK- -SKVQQIV- -K LFE- ^■AN— -QTADVKE— 1277 WP_002310644 1220 KQYDEIShKESF- D YVNEHHKEFSEVFARVLEFAGKYTLAE- -KNIEKLE- -K IYK- ^■EN— -QTDDLAK— 1279 WP_002312694 1221 KQYDEIShKESF- D YVNEHHKEFSEVFARVLEFAGKYTLAE- -KNIEKLE- -K IYK- ^■EN— -QTDDLAK— 1280 WP_002314015 1221 KQYDEIShKESF- D Y EHHKEFSEVFARVLEFAGKYTLAE- -KNIEKLE- -K IYK- ^■EN— -QTDDLAK— 1280 WP_002320716 1221 KQYDEIShKESF- D Y EHHKEFSEVFARVLEFAGKYTLAE- -KNIEKLE- -K IYK- ^■EN— -QTDDLAK— 1280 WP_002330729 1220 KQYDEIShKESF- D Y EHHKEFSEVFARVLEFAGKYTLAE- -KNIEKLE- -K IYK- ^■EN— -QTDDLAK— 1279 WP_002335161 1221 KQYDEIShKESF- D Y EHHKEFSEVFARVLEFAGKYTLAE- -KNIEKLE- -K IYK- ^■EN— -QTDDLAK— 1280 WP_002345439 1221 KQYDEIShKESF- D YVNEHHKEFSEVFARVLEFAGKYTLAE- -KNIEKLE- -K IYK- ^■EN— -QTDDLAK— 1280 WP_034867970 1211 QHYDKITyQESF- D Y THLSDFSAILTEVLAFAEKYTLAD- -KNIERIQ- -E LYE- ^■EN— -KYGETSM— 1270 WP_047937432 1221 KQYDEIShKESF- D YVNEHHKEFSEVFARVLEFAGKYTLAE- -KNIEKLE- -K IYK- ^■EN— -QTDDLAK— 1280 WP_010720994 1211 QHYDKITyQESF- D Y THLSDFSAILTEVLAFAEKYTLAD- -KNIERIQ- -E LYE- ^■EN— -KYGEISM— 1270 WP_010737004 1211 QHYDKITyQESF- D YVNTHLSDFSAILTEVLAFAEKYTLAD- -KNIERIQ- -E LYE- ^■EN— -KYGETSM— 1270 WP_034700478 1211 QHYDKITyQESF- D YVNTHLSDFSAILTEVLAFAEKYTLAD- -KNIERIQ- -E LYE- ^■EN— -KYGEISM— 1270 WP_007209003 1209 KKIIN—gKNSD- -SVS YIQNNKEKFREIFEYIVDFSSKYISAD- -ANLNKIE- -K IFE- ^■NNfh KASEqe 1269 WP_023519017 1205 RHYDEINhKVSF- D YVNAHKEGFNDI FDFI SDFGVRYILAP- -QHLEKIK- -V AYE- ^■KN— -KEVDLKE— 1264 WP_010770040 1216 KQVDE-- -DS- GKSEE YVREHRAEFAEILNYVQAFSETKILAN- -KNLQTIL- -K LYE- ^■EN— -KEADIKE— 1274 WP_048604708 1213 KHCNE-- -KP- D-SLK YVTEHQSGFSEIMAHVKDFAEKYTLVD- -KNLEKIL- -s LYA- ^■KN— -MDSEVKE— 1270 WP_010750235 1214 NHYDEIAyKDSY- --D YVNEHFSNFQDILDKVI I FAEKYTSAP- -QKLNQII- -A TYE- ^■KN— -QEADRKI— 1273 All 16583 1279 SHYEKLKgSPEDnEQKQL-- FVEQHKHYLDEIIEQISEFSKRVILAD- -ANLDKVL- -s AYN- ^■KH— -RDKPIREq- 1344 WP_02 9073316 1226 YKAMKYK-NYSElSQEEIm- NVYDI FVEKLKLYYPTY-kNIATNFE- -N FEN- i SDEEk- 1282 WP_031589969 1226 YKAMKYK-NYDNlDSEKIi- DLYRLLINKMELYYPEYrkQLVKKFE- -D LKV- i SIEEk- 1283 KDA45870 1200 NAKDG EQKLE-- DHKAEFKELFDKIMEFADKYWAP- -KNSEKIR- -R LYE- ^■ENq- DATPme 1253 WP_03 9099354 1242 LPLTQ SEeLAEQV-- YDEILDQVMHYFPLYDTNQfrAKLSAGKaA DGN- ^■KMv- QVGQqv 1306 AKP02966 1238 QIPDE DpDQILAf- YDKNILVEILQELITKMKKFYPFY—KNEQEFLaS FNQ- ATTSEk- 1296 WP_01 0991369 1216 ANCEV-- SD- GKSLD- YIESNREMFAELLAHVSEFAKRYTLAE—ANLNKIN-Q LFE- ^■QN— -KEGDIKA— 1274 WP_033838504 1216 ANCEV-- SD- GKSLD- YIESNREMFAELLAHVSEFAKRYTLAE—ANLNKIN-Q LFE- ^■QN— -KEGDIKA— 1274 EHN60060 1219 ANCEV-- SD- GKSLD- YIESNREMFAELLAHVSEFAKRYTLAE—ANLNKIN-Q LFE- ^■QN— -KEGDIKA— 1277 EFR89594 985 ANCEV-- SD- GKSLD- YIESNREMFAELLAHVSEFAKRYTLAE—ANLNKIN-Q LFE- ^■QN— -KEGDIKA— 1043 WP_03 8409211 1216 KNCEA-- ND- GESLA- YIEMHREMFAELLAYI SEFAKRYTLAN—DRLEKIN-M FFE- ^■QN— -KKGDIKV— 1274 EFR95520 835 KNCEA-- ND- GESLA- YIEMHREMFAELLAYI SEFAKRYTLAN—DRLEKIN-M FFE- ^■QN— -KKGDIKV— 893 WP_00 3723650 1216 KNCEA-- SD- GKSLK- YIEAHRETFSELLAQVSEFATRYTLAD—ANLSKIN-N LFE- ^■QN— -KEGDIKA— 1274 WP_003727705 1216 KNCEA-- SD- GKSLK- YIEAHRETFSELLAQVSEFATKYTLAD—ANLSKIN-N LFE- ^■QN— -KEGDIKA— 1274 WP_003730785 1216 KNCEA-- SD- GKSLK- YIEAHRETFSELLAQVSEFATKYTLAD—ANLSKIN-N LFE- ^■QN— -KEGDIKA— 1274 WP_003733029 1216 EKYEA-- ID- GESLA- YIEVHRALFDELLAYISEFARKYTLSN—DRLDEIN-M LYE- ^■RN— -KDGDVKS— 1274 WP 003739838 1216 KNCEA-- SD- GKSLD- YIESNREMFGELLAHVSEFAKRYTLAD—ANLSKIN-Q LFE- ^■QN— -KDNDIKV— 1274

WP 014601172 1216 KNCEA SD-GKSLK--YIEAHRETFSELLAQVSEFATRYTLAD--ANLSKIN--N LFE-^■QN---KEGDIQA— 1274

WP 023548323 1216 EKREA ID-GESLA- -YIEAHKAVFGELLAHI SEFARKYTLAN- -DKLDEIN- -M LYE- ^■RN- - -KDGDVKS— 1274

WP 031665337 1216 KNCEA SD-GKSLK- -YIEAHRETFSELLAQVSEFATRYTLAD- -ANLSKIN- -N LFE- ^■QN- - -KEGDIKA— 1274

WP 031669209 1216 EKYEA ID-GESLA- -YIEVHRALFDELLAYISEFARKYTLSN- -DRLDEIN- -M LYE- ^■RN- - -KDGDVKS— 1274

WP 033920898 1216 EKREA ID-GESLA- -YIEAHKAVFGELLAHI SEFARKYTLAN- -DKLDEIN- -M LYE- ^■RN- - -KDGDVKS— 1274

AKI42028 1219 KNCEA SD-GKSLK- -YIEAHRETFSELLAQVSEFATRYTLAD- -ANLSKIN- -N LFE- ^■QN- - -KEGDIQA— 1277

AKI50529 1219 EKREA ID-GESLA- -YIEAHKAVFGELLAHI SEFARKYTLAN- -DKLDEIN- -M LYE- ^■RN- - -KDGDVKS— 1277

EFR83390 664 KNCEA SD-GKSLK- -YTEAHRETFSELLAQVSEFATRYTLAD- -ANLSKIN- -N LFE- ^■QN- - -KEGDIKX— 722

WP 046323366 1216 KNCEA SD-GKSLA- -YIESHREMFAELLDSISEFASRYTLAD- -ANLEKIN- -T IFE- ^■QN- - -KSGDVKV— 1274

AKE81011 1256 SHYEKLKgSPEDnEQKQL- -FVEQHKHYLDEIIEQISEFSKRVILAD- -ANLDKVL- -s AYN- ^■KH- - -RDKPIREq- 1321

CU082355 1216 YNAIYKQ-DFDG1DNMLMi QLYLQLIDKLKTLYPIY-mGIVEKFE- -K FVS- i SKEEk- 1272

WP 033162887 1218 YAAMLKK-RYEY1DEEEI f DLYLQLLQKMDTLYPAY-kGIAKRFF- -D FKN- i DWEk- 1274

AGZ 01981 1273 SHYEKLKgSPEDnEQKQL- -FVEQHKHYLDEIIEQISEFSKRVILAD- -ANLDKVL- -s AYN- ^■KH- - -RDKPIREq- 1338

AKA60242 1240 SHYEKLKgSPEDnEQKQL- -FVEQHKHYLDEIIEQISEFSKRVILAD- -ANLDKVL- -s AYN- ^■KH- - -RDKPIREq- 1305

AKS40380 1240 SHYEKLKgSPEDnEQKQL- -FVEQHKHYLDEIIEQISEFSKRVILAD- -ANLDKVL- -s AYN- ^■KH- - -RDKPIREq- 1305

4UN5 B 1244 SHYEKLKgSPEDnEQKQL- -FVEQHKHYLDEIIEQISEFSKRVILAD- -ANLDKVL- -s AYN- ^■KH- - -RDKPIREq- 1309

WP 010922251 1306 -AE---Nil HLFTLTNLGAP-AAFKYFD- -DRK--R--YTSTKEVL DATLIHQSITGLYETRIDLSQL-- 1365

WP 039695303 1309 ISN- - -SFI NLLTLTALGAP-ADFNFLG- PRK- -R- -YTSTKECL NATLIHQSITGLYETRIDLSKL- - 1369

WP 045635197 1307 LAN- - -SFI NLLTFTALGAP-AAFKFFG- DRK- -R- -YTTVSEIL NATLIHQSITGLYETWIDLSKL- - 1367

5AXW A

WP 009880683 990 -AE- - -Nil HLFTLTNLGAP- AAFKCFD- TTI GRN- -R- -YKSIKEVL DATLIHQSITGLYETRIDLSQL- - 1049

WP 010922251 1306 -AE- - -Nil HLFTLTNLGAP-AAFKYFD- TTI DRK- -R- -YTSTKEVL DATLIHQSITGLYETRIDLSQL- - 1365

WP 011054416 1306 -AE- - -Nil HLFTLTNLGAP-AAFKYFD- TTI DRK- -R- -YTSTKEVL DATLIHQSITGLYETRIDLSQL- - 1365

WP 011284745 1306 -AE- - -Nil HLFTLTNLGAP-AAFKYFD- TTI DRK- -R- -YTSTKEVL DATFIHQSITGLYETRIDLSQL- - 1365

WP 011285506 1306 -AE- - -Nil HLFTLTNLGAP-AAFKYFD- TTI DRK- -R- -YTSTKEVL DATLIHQSITGLYETRIDLSQL- - 1365

WP 011527619 1306 -AE- - -Nil HLFTLTNLGAP-TAFKYFD- TTI DRK- -R- -YTSTKEVL DATFIHQSITGLYETRIDLSQL- - 1365

WP 012560673 1306 -AE- - -Nil HLFTLTNLGAP-AAFKCFD- TTI GRN- -R- -YKSIKEVL DATLIHQSITGLYETRIDLSQL- - 1365

WP 014407541 1305 -AE- - -Nil HLFTLTNLGAP-AAFKYFD- TTI DRK- -R- -YTSTKEVL DATLIHQSITGLYETRIDLSQL- - 1364

WP 020905136 1306 -AE- - -Nil HLFTLTNLGAP-AAFKYFD- TTI DRK- -R- -YTSTKEVL DATLIHQSITGLYETRIDLSQL- - 1365

WP 023080005 1305 -AK- - -Nil HLFTLTNLGAP-AAFKYFD- TTI ERN- -R- -YKSIKEVL DATLIHQSITGLYETRIDLSQL- - 1364

WP 023610282 1305 -AK- - -Nil HLFTLTNLGAP-AAFKYFD- TTI ERN- -R- -YKSIKEVL DATLIHQSITGLYEIRIDLSQL- - 1364

WP 030125963 1306 -AE- - -Nil HLFTLTNLGAP-AAFKYFD- TTI GRN- -R- -YKSIKEVL DATLIHQSITGLYETRIDLSQL- - 1365

WP 030126706 1306 -AE- - -Nil HLFTLTNLGAP-AAFKYFD- TTI DRK- -R- -YTSTKEVL DATLIHQSITGLYETRIDLSQL- - 1365

WP 031488318 1306 -AE- - -Nil HLFTLTNFGAP-AAFIYFD- TTI GRN- -R- -YKSIKEVL DATLIHQSITGLYETRIDLSQL- - 1365

WP 032460140 1306 -AE- - -Nil HLFTLTNLGAP-AAFKYFD- TTI GRN- -R- -YKSIKEVL DATLIHQSITGLYETRIDLSQL- - 1365

WP 032461047 1306 -AE- - -Nil HLFTLTNLGAP-AAFKYFD- TTI GRN- -R- -YKSIKEVL DATLIHQSITGLYETRIDLSQL- - 1365

WP 032462016 1306 -AE- - -Nil HLFTLTNLGAP-AAFKYFD- TTI DRK- -R- -YTSTKEVL DATLIHQSITGLYETRIDLSQL- - 1365

WP 032462936 1306 -AE- - -Nil HLFTLTNLGAP-AAFKYFD- TTI DRK- -R- -YTSTKEVL DATLIHQSITGLYETRIDLSQL- - 1365

WP 032464890 1306 -AE- - -Nil HLFTLTNLGAP-TAFKYFD- TTI DRK- -R- -YTSTKEVL DATFIHQSITGLYETRIDLSQL- - 1365

WP 033888930 1131 -AE- - -Nil HLFTLTNLGAP-AAFKYFD- TTI DRK- -R- -YTSTKEVL DATLIHQSITGLYETRIDLSQL- - 1190

WP 038431314 1306 -AE- - -Nil HLFTLTNLGAP-AAFKYFD- TTI DRK- -R- -YTSTKEVL DATLIHQSITGLYETRIDLSQL- - 1365

WP 038432938 1305 -AK- - -Nil HLFTLTNLGAP-AAFKYFD- TTI ERN- -R- -YKSIKEVL DATLIHQSITGLYETRIDLSQL- - 1364

WP 038434062 1306 -AE- - -Nil HLFTLTNLGAP-AAFKYFD- TTI GRN- -R- -YKSIKEVL DATLIHQSITGLYETRIDLSQL- - 1365

BAQ51233 1217 -AE- - -Nil HLFTLTNLGAP-AAFKYFD- TTI DRK- -R- -YTSTKEVL DATLIHQSITGLYETRIDLSQL- - 1276

KGE60162 481 -AE- - -Nil HLFTLTNLGAP-AAFKYFD- TTI DRK- -R- -YTSTKEVL DATLIHQSITGLYETRIDLSQL- - 540

KGE60856 244 -AE- - -Nil HLFTLTNLGAP-AAFKYFD- TTI DRK- -R- -YTSTKEVL DATLIHQSITGLYETRIDLSQL- - 303

WP 002989955 1306 -AE- - -Nil HLFTLTNLGAP-TAFKYFD- TTI DRK- -R- -YTSTKEVL DATFIHQSITGLYETRIDLSQL- - 1365

WP 003030002 1282 LAK- - -SFI SLLTFTAFGAP-AAFNFFG- ENI DRK- -R- -YTSVTECL NATLIHQSITGLYETRIDLSKL- - 1342

WP 003065552 1310 ISN- - -SFI NLLTLTALGAP-ADFNFLG- EKI PRK- -R- -YTSTKECL NATLIHQSITGLYETRIDLSKI- - 1370

WP 001040076 1307 LAN- - -Nil NLFTFTSLGAP-AAFKFFD- KIV- DRK- -R- -YTSTKEVL NSTLIHQSITGLYETRIDLGKL- - 1367

WP 001040078 1315 LAN- - -Nil NLFTFTSLGAP-AAFKFFD- KIV- DRK- -R- -YTSTKEVL NSTLIHQSITGLYETRIDLSKL- - 1375

WP 001040080 1307 LAN- - -Nil NLFTFTSLGAP-AAFKFFD- KIV- DRK- -R- -YTSTKEVL NSTLIHQSITGLYETRIDLGKL- - 1367

WP 001040081 1307 LAN- - -Nil NLFTFTSLGAP-AAFKFFD- KIV- DRK- -R- -YTSTKEVL NSTLIHQSITGLYETRIDLGKL- - 1367

WP 001040083 1307 LAN- - -Nil NLFTFTSLGAP-AAFKFFD- KIV- DRK- -R- -YTSTKEVL NSTLIHQSITGLYETRIDLGKL- - 1367

WP 001040085 1307 LAN- - -Nil NLFTFTSLGAP-AAFKFFD- KIV- DRK- -R- -YTSTKEVL NSTLIHQSITGLYETRIDLGKL- - 1367

WP 001040087 1307 LAN---Nil NLFTFTSLGAP--AAFKFFD--KIV--DRK -R--YTSTKEVL NSTLIHQSITGLYETRIDLGKL— 1367

WP ^"001040088 1307 LAN- - -Nil NLFTFTSLGAP- -AAFKFFD- -KIV- -DRK -R- -YTSTKEVL NSTLIHQSITGLYETRIDLGKL— 1367

WP ^"001040089 1307 LAN- - -Nil NLFTFTSLGAP- -AAFKFFD- -KIV- -DRK -R- -YTSTKEVL NSTLIHQSITGLYETRIDLGKL— 1367

WP ^"001040090 1307 LAN- - -Nil NLFTFTSLGAP- -AAFKFFD- -KIV- -DRK -R- -YTSTKEVL NSTLIHQSITGLYETRIDLGKL— 1367

WP ^"001040091 1307 LAN- - -Nil NLFTFTSLGAP- -AAFKFFD- -KIV- -DRK -R- -YTSTKEVL NSTLIHQSITGLYETRIDLGKL— 1367

WP ^"001040092 1307 LAK- - -Nil NLFTFTSLGAP- -AAFKFFD- -KSV- -DRK -R- -YTSTKEVL DSTLIHQSITGLYETRIDLGKL— 1367

WP ^"001040094 1307 LAN- - -Nil NLFTFTSLGAP- -AAFKFFD- -KIV- -DRK -R- -YTSTKEVL NSTLIHQSITGLYETRIDLGKL— 1367

WP ^"001040095 1307 LAN- - -Nil NLFTFTSLGAP- -AAFKFFD- -KIV- -DRK -R- -YTSTKEVL NSTLIHQSITGLYETRIDLGKL— 1367

WP ^"001040096 1307 LAN- - -Nil NLFTFTSLGAP- -AAFKFFD- -KIV- -DRK -R- -YTSTKEVL NSTLIHQSITGLYETRIDLGKL— 1367

WP ^"001040097 1307 LAN- - -Nil NLFTFTSLGAP- -AAFKFFD- -KIV- -DRK -R- -YTSTKEVL NSTLIHQSITGLYETRIDLGKL— 1367

WP ^"001040098 1307 LAN- - -Nil NLFTFTSLGAP- -AAFKFFD- -KIV- -DRK -R- -YTSTKEVL NSTLIHQSITGLYETRIDLGKL— 1367

WP ^"001040099 1307 LAN- - -Nil NLFTFTSLGAP- -AAFKFFD- -KIV- -DRK -R- -YTSTKEVL NSTLIHKSITGLYETRIDLGKL— 1367

WP ^"001040100 1307 LAN- - -Nil NLFTFTSLGAP- -AAFKFFD- -KIV- -DRK -R- -YTSTKEVL NSTLIHQSITGLYETRIDLGKL— 1367

WP ^"001040104 1307 LAN- - -Nil NLFTFTSLGAP- -AAFKFFD- -KIV- -DRK -R- -YTSTKEVL NSTLIHQSITGLYETRIDLGKL— 1367

WP ^"001040105 1307 LAN- - -Nil NLFTFTSLGAP- -AAFKFFD- -KIV- -DRK -R- -YTSTKEVL NSTLIHQSITGLYETRIDLGKL— 1367

WP ^"001040106 1307 LAN- - -Nil NLFTFTSLGAP- -AAFKFFD- -KIV- -DRK -R- -YTSTKEVL NSTLIHQSITGLYETRIDLGKL— 1367

WP ^"001040107 1307 LAN- - -Nil NLFTFTSLGAP- -AAFKFFD- -KIV- -DRK -R- -YTSTKEVL NSTLIHQSITGLYETRIDLGKL— 1367

WP ^"001040108 1307 LAN- - -Nil NLFTFTSLGAP- -AAFKFFD- -KIV- -DRK -R- -YTSTKEVL NSTLIHQSITGLYETRIDLGKL— 1367

WP ^"001040109 1307 LAN- - -Nil NLFTFTSLGAP- -AAFKFFD- -KIV- -DRK -R- -YTSTKEVL NSTLIHQFITGLYETRIDLGKL— 1367

WP ^"001040110 1307 LAN- - -Nil NLFTFTSLGAP- -AAFKFFD- -KIV- -DRK -R- -YTSTKEVL NSTLIHQSITGLYETRIDLGKL— 1367

WP ^"015058523 1307 LAK- - -Nil NLFTFTSLGAP- -AAFKFFD- -KSV- -DRK -R- -YTSTKEVL DSTLIHQSITGLYETRIDLGKL— 1367

WP ^"017643650 1307 LAN- - -Nil NLFTFTSLGAP- -AAFKFFD- -KIV- -DRK -R- -YTSTKEVL NSTLIHQSITGLYETRIDLGKL— 1367

WP ^"017647151 1307 LAN- - -Nil NLFTFTSLGAP- -AAFKFFD- -KIV- -DRK -R- -YTSTKEVL NSTLIHQSITGLYETRIDLGKL— 1367

WP ^"017648376 1307 LAN- - -Nil NLFTFTSLGAP- -AAFKFFD- -KIV- -DRK -R- -YTSTKEVL NSTLIHQSITGLYETRIDLGKL— 1367

WP ^"017649527 1307 LAN- - -Nil NLFTFTSLGAP- -AAFKFFD- -KIV- -DRK -R- -YTSTKEVL NSTLIHQSITGLYETRIDLGKL— 1367

WP ^"017771611 1307 LAN- - -Nil NLFTFTSLGAP- -AAFKFFD- -KIV- -DRK -R- -YTSTKEVL NSTLIHQSITGLYETRIDLGKL— 1367

WP ^"017771984 1307 LAN- - -Nil NLFTFTSLGAP- -AAFKFFD- -KIV- -DRK -R- -YTSTKEVL NSTLIHQSITGLYETRIDLGKL— 1367

CFQ25032 1307 LAN- - -Nil NLFTFTSLGAP- -AAFKFFD- -KIV- -DRK -R- -YTSTKEVL NSTLIHQSITGLYETRIDLGKL— 1367

CFV16040 1307 LAN- - -Nil NLFTFTSLGAP- -AAFKFFD- -KIV- -DRK -R- -YTSTKEVL NSTLIHQSITGLYETRIDLGKL— 1367

KLJ37842 1307 LAN- - -Nil NLFTFTSLGAP- -AAFKFFD- -KIV- -DRK -R- -YTSTKEVL NSTLIHQSITGLYETRIDLGKL— 1367

KLJ72361 1307 LAN- - -Nil NLFTFTSLGAP- -AAFKFFD- -KIV- -DRK -R- -YTSTKEVL NSTLIHQSITGLYETRIDLGKL— 1367

KLL20707 1321 LAN- - -Nil NLFTFTSLGAP- -AAFKFFD- -KIV- -DRK -R- -YTSTKEVL NSTLIHQSITGLYETRIDLGKL— 1381

KLL42645 1307 LAN- - -Nil NLFTFTSLGAP- -AAFKFFD- -KIV- -DRK -R- -YTSTKEVL NSTLIHQSITGLYETRIDLGKL— 1367

WP 047207273 1307 LAN- - -Nil NLFTFTSLGAP- -AAFKFFD- -KIV- -DRK -R- -YTSTKEVL NSTLIHQSITGLYETRIDLGKL— 1367

WP ^"047209694 1307 LAN- - -Nil NLFTFTSLGAP- -AAFKFFD- -KIV- -DRK -R- -YTSTKEVL NSTLIHKSITGLYETRIDLGKL— 1367

WP ^"050198062 1307 LAN- - -Nil NLFTFTSLGAP- -AAFKFFD- -KIV- -DRK -R- -YTSTKEVL NSTLIHQSITGLYETRIDLGKL— 1367

WP ^"050201642 1307 LAN- - -Nil NLFTFTSLGAP- -AAFKFFD- -KIV- -DRK -R- -YTSTKEVL NSTLIHQSITGLYETRIDLGKL— 1367

WP ^"050204027 1307 LAN- - -Nil NLFTFTSLGAP- -AAFKFFD- -KIV- -DRK -R- -YTSTKEVL NSTLIHQSITGLYETRIDLGKL— 1367

WP ^"050881965 1307 LAN- - -Nil NLFTFTSLGAP- -AAFKFFD- -KII- -DRK -R- -YTSTKEVL NSTLIHQSITGLYETRIDLGKL— 1367

WP 050886065 1307 LAN-—Nil NLFTFTSLGAP--AAFKFFD--KIV--DRK--R-^■YTSTKEVL NSTLIHQSITGLYETRIDLGKL— 1367

AHN30376 13 07 LAK- —Nil NLFTFTSLGAP- -AAFKFFD- -KSV- -DRK- -R- ^■YTSTKEVL DSTLIHQSITGLYETRIDLGKL— 1367

EA078426 13 07 LAN- —Nil NLFTFTSLGAP- -AAFKFFD- -KIV- -DRK- -R- ^■YTSTKEVL NSTLIHQSITGLYETRIDLGKL— 1367

CCW42055 13 07 LAN- —Nil NLFTFTSLGAP- -AAFKFFD- -KIV- -DRK- -R- ^■YTSTKEVL NSTLIHQSITGLYETRIDLGKL— 1367

WP 003041502 13 14 ICT- —SFL GLFELTSLGSA- -SDFEFLG- -VKI- -PRY- -RdYTPSSLLK DSTLIHQSITGLYETRIDLSKL— 1383

WP 037593752 12 83 LAK- —SFI SLLTFTAFGAP- -AAFNFFG- -ENI- -DRK- -R- ^■YTSVTECL NATLIHQSITGLYETRIDLSKL— 1343

WP 049516684 12 83 LAK- —SFI SLLTFTAFGAP- -AAFNFFG- -ENI- -DRK- -R- ^■YTSVTECL NATLIHQSITGLYETRIDLSKL— 1343

GAD46167 12 82 LAK- —SFI SLLTFTAFGAP- -AAFNFFG- -ENI- -DRK- -R- ^■YTSVTECL NATLIHQSITGLYETRIDLSKL— 1342

WP 018363470 13 14 ISD- —SFI NLLTLTALGAP- -ADFNFLG- -EKI- -PRK- -R- ^■YNSTKECL NATLIHQSITGLYETRIDLSKL— 1374

WP 003043819 13 11 -SN- —SFV SLLKYTSFGAS- -GGFTFLD- -LDVkqGRL- -R- ^■YQTVTEVL DATLIYQSITGLYETRTDLSQL— 1372

WP 006269658 12 82 LAK- —SFI SLLTFTAFGAP- -AAFNFFG- -ENI- -DRK- -R- ^■YTSVTECL NATLIHQSITGLYETRIDLSKL— 1342

WP 048800889 13 02 ISN- —SFI HLLTLTALGAP- -ADFNFLG- -EKI- -PRK- -R- ^■YTSTKECL NATLIHQSITGLYETQTDLSKL— 1362

WP 012767106 13 09 -CS- —SVI NLLTLTASGAP- -ADFKFLG- -TTI- -PRK- -R- ^■YGSPQSIL SSTLIHQSITGLYETRIDLSQL— 1368

WP 014612333 13 09 -CS- —SVI NLLTLTASGAP- -ADFKFLG- -TTI- -PRK- -R- ^■YGSPQSIL SSTLIHQSITGLYETRIDLSQL— 1368

WP 015017095 13 09 -CS- —SVI NLLTLTASGAP- -ADFKFLG- -TTI- -PRK- -R- ^■YGSPQSIL SSTLIHQSITGLYETRIDLSQL— 1368

WP 015057649 13 09 -CS- —SVI NLLTLTASGAP- -ADFKFLG- -TTI- -PRK- -R- ^■YGSPQSIL SSTLIHQSITGLYETRIDLSQL— 1368

WP 048327215 13 09 -CS- —SVI NLLTLTASGAP- -ADFKFLG- -TTI- -PRK- -R- ^■YGSPQSIL SSTLIHQSITGLYETRIDLSQL— 1368

WP 049519324 13 09 -CS- —SVI NLLTLTASGAP- -ADFKFLG- -TTI- -PRK- -R- ^■YGSPQSIL SSTLIHQSITGLYETRIDLSQL— 1368

WP 012515931 12 86 -AE- —Nil NVFTFVALGAP- -AAFKFFD- -ATI- -DRK- -R- ^■YTSTKEVL NATLIHQSVTGLYETRIDLSQL— 1345

WP 021320964 12 86 -AE- —Nil NVFTFVALGAP- -AAFKFFD- -ATI- -DRK- -R- ^■YTSTKEVL NATLIHQSVTGLYETRIDLSQL— 1345

WP 037581760 12 86 -AE- —Nil NVFTFVALGAP- -AAFKFFD- -ATI- -DRK- -R- ^■YTSTKEVL NATLIHQSVTGLYETRIDLSQL— 1345

WP 004232481 13 09 ISSlseSFI NLLKFISFGAP- -GAFKFLK- -LDV- -KQSnlR- ^■YKSTTEAL SATLIHQSVTGLYETRIDLSKL— 1374

WP 009854540 13 07 ISN- —SFI NLLTLTALGAP- -ADFNFLG- -EKI- -PRK- -R- ^■YTSTKECL TATLIHQSITGLYETRIDLSKL— 1367

WP 012962174 13 08 ISI- —SFV NLLTLTALGAP- -ADFNFLG- -EKI- -PRK- -R- ^■YTSTKECL NATLIHQSITGLYETRIDLSKL— 1368

WP 039695303 13 09 ISN- —SFI NLLTLTALGAP- -ADFNFLG- -EKI- -PRK- -R- ^■YTSTKECL NATLIHQSITGLYETRIDLSKL— 1369

WP 014334983 13 12 ISA- —SFI NLLTLTALGAP- -ADFNFLG- -EKI- -PRK- -R- ^■YTSTKECL SATLIHQSVTGLYETRIDLSKL— 1372

WP 003099269 13 06 -AI- —NML NLFTFTDLGAP- -SAFKFFN- -GDI- -DRK- -R- ^■YSSTNEII NSTLIYQSPTGLYETRIDLSKL— 1365

AHY15608

AHY17476

ESR09100 13 8 -AI- —NML NLFTFTDLGAP- -SAFKFFNg —DI- -DRK- -R- ^■YSSTNEII NSTLIYQSPTGLYETRIDLSKL— 197

AGM98575

ALF27331 12 82 LAS- —SFI NLLTFTAIGAP- -AAFKFFD- -NNI- -DRK- -R- ^■YTSTTEIL NATLIHQSITGLYETRIDLSRL— 1342

WP 018372492 12 90 VAR- —SFV -LLNFTMMGAA- -TDFKFFG- -QII- -PRK- -R- ^■YPSTTECL KSTLIHQSVTGLYETRIDLSKL— 1350

WP 045618028 13 11 LSE- —SFI SLLKLISFGAP- -GTFKFLG- -VEI- -SQSnvR- ^■YQSVSSCF NATLIHQSITGLYETRIDLSKL— 1373

WP 045635197 13 07 LAN- —SFI NLLTFTALGAP- -AAFKFFG- -KDI- -DRK- -R- ^■YTTVSEIL NATLIHQSITGLYETWIDLSKL— 1367

WP 002263549 12 82 LAS- —SFI NLLTFTAIGAP- -ATFKFFD- -KNI- -DRK- -R- ^■YTSTTEIL NATLIHQSITGLYETRIDLNKL— 1342

WP 002263887 12 82 LAS- —SFI NLLTFTAIGAP- -ATFKFFD- -KNI- -DRK- -R- ^■YTSTTEIL NATLIHQSITGLYETRIDLNKL— 1342

WP 002264920 12 82 LAS- —SFI NLLTFTAIGAP- -ATFKFFD- -KNI- -DRK- -R- ^■YTSTTEIL NATLIHQSITGLYETRIDLSKL— 1342

WP 002269043 12 82 LAS- —SFI NLLTFTAIGAP- -ATFKFFD- -KNI- -DRK- -R- ^■YTSTTEIL NATLIHQSITGLYETRIDLNKL— 1342

WP 002269448 1282 LAS---SFI NLLTFTAIGAP-ATFKFFD- KNI DRK--R--YTSTTEIL NATLIHQSITGLYETRIDLSKL-- 1342

WP ^"002271977 12 82 LAS- - -SFI NLLTFTAIGAP-ATFKFFD- KNI DRK- -R- -YTSTTEIL NATLIHQSITGLYETRIDLSKL- - 1342

WP ^"002272766 12 82 LAS- - -SFI NLLTFTAIGAP-ATFKFFD- KNI DRK- -R- -YTSTTEIL NATLIHQSITGLYETRIDLSKL- - 1342

WP ^"002273241 12 82 LAS- - -SFI NLLTFTAIGAP-ATFKFFD- KNI DRK- -R- -YTSTTEIL NATLIHQSITGLYETRIDLSKL- - 1342

WP ^"002275430 12 82 LSS- - -SFI NLLTFTAIGAP-AAFKFFD- KNI DRK- -R- -YTSTTEIL NATLIHQSITGLYETRIDLSKL- - 1342

WP ^"002276448 12 82 LAS- - -SFI NLLTFTAIGAP-ATFKFFD- KNI DRK- -R- -YTSTTEIL NATLIHQSITGLYETRIDLSKL- - 1342

WP ^"002277050 12 88 LAD- - -GFI KLLGFTQLGAT-SPFSFLG- IKL- NQK- -Q- -YTGKKDYL EATLIHQSITGLYETRIDLNKL- - 1352

WP ^"002277364 12 82 LAS- - -SFI NLLTFTAIGAP-ATFKFFD- KNI DRK- -R- -YTSTTEIL NATLIHQSITGLYETRIDLSKL- - 1342

WP ^"002279025 12 82 LAS- - -SFI NLLTFTAIGAP-ATFKFFD- KNI DRK- -R- -YTSTTEIL NATLIHQSITGLYETRIDLSKL- - 1342

WP ^"002279859 12 82 LAS- - -SFI NLLTFTAIGAP-ATFKFFD- KNI DRK- -R- -YTSTTEIL NATLIHQSITGLYETRIDLSKL- - 1342

WP ^"002280230 12 82 LAS- - -SFI NLLTFTAIGAP-ATFKFFD- KNI DRK- -R- -YTSTTEIL NATLIHQSITGLYETRIDLSKL- - 1342

WP ^"002281696 12 82 LSS- - -SFI NLLTFTAIGAP-AAFKFFD- KNI DRK- -R- -YTSTTEIL NATLIHQSITGLYETRIDLSKL- - 1342

WP ^"002282247 12 88 LAD- - -GFI KLLGFTQLGAT-SPFSFLG- IKL- NQK- -Q- -YTGKKDYL EATLIHQSITGLYETRIDLSKL- - 1352

WP ^"002282906 12 82 LAS- - -SFI NLLTFTAIGAP-ATFKFFD- KNI DRK- -R- -YTSTTEIL NATLIHQSITGLYETRIDLSKL- - 1342

WP ^"002283846 12 82 LAS- - -SFI NLLTFTAIGAP-ATFKFFD- KNI DRK- -R- -YTSTTEIL NATLIHQSITGLYETRIDLSKL- - 1342

WP ^"002287255 12 82 LAS- - -SFI NLLTFTAIGAP-ATFKFFD- KNI DRK- -R- -YTSTTEIL NATLIHQSITGLYETRIDLSKL- - 1342

WP ^"002288990 12 82 LAS- - -SFI NLLTFTAIGAP-AAFKFFD- KNI DRK- -R- -YTSTTEIL NATLIHQSITGLYETRIDLSKL- - 1342

WP ^"002289641 12 82 LAS- - -SFI NLLTFTAIGAP-ATFKFFD- KNI DRK- -R- -YTSTTEIL NATLIHQSITGLYETRIDLSKL- - 1342

WP ^"002290427 12 82 LAS- - -SFI NLLTFTAIGAP-ATFKFFD- KNI DRK- -R- -YTSTTEIL NATLIHQSITGLYETRIDLSKL- - 1342

WP ^"002295753 12 82 LAS- - -SFI NLLTFTAIGAP-AAFKFFD- KNI DRK- -R- -YTSTTEIL NATLIHQSITGLYETRIDLSKL- - 1342

WP ^"002296423 12 82 LAS- - -SFI NLLTFTAIGAP-ATFKFFD- KNI DRK- -R- -YTSTTEIL NATLIHQSITGLYETRIDLSKL- - 1342

WP ^"002304487 12 96 LAS- - -SFI NLLTFTAIGAP-AAFKFFD- KNI DRK- -R- -YTSTTEIL NATLIHQSITGLYETRIDLNKL- - 1356

WP ^"002305844 12 82 LAS- - -SFI NLLTFTAIGAP-ATFKFFD- KNI DRK- -R- -YTSTTEIL NATLIHQSITGLYETRIDLSKL- - 1342

WP ^"002307203 12 82 LAS- - -SFI NLLTFTAIGAP-ATFKFFD- KNI DRK- -R- -YTSTTEIL NATLIHQSITGLYETRIDLSKL- - 1342

WP ^"002310390 12 82 LAS- - -SFI NLLTFTAIGAP-ATFKFFD- KNI DRK- -R- -YTSTTEIL NATLIHQSITGLYETRIDLSKL- - 1342

WP ^"002352408 12 82 LAS- - -SFI NLLTFTAIGAP-ATFKFFD- KNI DRK- -R- -YTSTTEIL NATLIHQSITGLYETRIDLSKL- - 1342

WP ^"012997688 12 82 LAS- - -SFI NLLTFTAIGAP-ATFKFFD- KNI DRK- -R- -YTSTTEIL NATLIHQSITGLYETRIDLSKL- - 1342

WP ^"014677909 12 82 LAS- - -SFI NLLTFTAIGAP-ATFKFFD- KNI DRK- -R- -YTSTTEIL NATLIHQSITGLYETRIDLSKL- - 1342

WP ^"019312892 12 82 LAS- - -SFI NLLTFTAIGAP-ATFKFFD- KNI DRK- -R- -YTSTTEIL NATLIHQSITGLYETRIDLSKL- - 1342

WP ^"019313659 12 82 LAS- - -SFI NLLTFTAIGAP-ATFKFFD- KNI DRK- -R- -YTSTTEIL NATLIHQSITGLYETRIDLNKL- - 1342

WP ^"019314093 12 82 LAS- - -SFI NLLTFTAIGAP-AAFKFFD- KNI DRK- -R- -YTSTTEIL NATLIHQSITGLYETRIDLSKL- - 1342

WP ^"019315370 12 82 LSS- - -SFI NLLTFTAIGAP-AAFKFFD- KNI DRK- -R- -YTSTTEIL NATLIHQSITGLYETRIDLSKL- - 1342

WP ^"019803776 12 82 LAS- - -SFI NLLTFTAIGAP-ATFKFFD- KNI DRK- -R- -YTSTTEIL NATLIHQSITGLYETRIDLNKL- - 1342

WP ^"019805234 12 82 LAS- - -SFI NLLTFTAIGAP-ATFKFFD- KNI DRK- -R- -YTSTTEIL NATLIHQSITGLYETRIDLSKL- - 1342

WP ^"024783594 12 82 LAS- - -SFI NLLTFTAIGAP-ATFKFFD- KNI DRK- -R- -YTSTTEIL NATLIHQSITGLYETRIDLNKL- - 1342

WP ^"024784288 12 88 LAD- - -GFI KLLGFTQLGAT-SPFSFLG- IKL- NQK- -Q- -YTGKKDYL EATLIHQSITGLYETRIDLSKL- - 1352

WP ^"024784666 12 82 LAS- - -SFI NLLTFTAIGAP-ATFKFFD- KNI DRK- -R- -YTSTTEIL NATLIHQSITGLYETRIDLSKL- - 1342

WP ^"024784894 12 82 LAS- - -SFI NLLTFTAIGAP-ATFKFFD- KNI DRK- -R- -YTSTTEIL NATLIHQSITGLYETRIDLSKL- - 1342

WP ^"024786433 12 88 LAD- - -GFI KLLGFTQLGAT-SPFSFLG- IKL- NQK- -Q- -YTGKKDYL EATLIHQSITGLYETRIDLSKL- - 1352

WP 049473442 1282 LAS---SFI NLLTFTAIGAP-ATFKFFD- KNI--DRK- R-YTSTTEIL NATLIHQSITGLYETRIDLSKL— 1342

WP 049474547 1282 LAS- - -SFI NLLTFTAIGAP-ATFKFFD- KNI- -DRK- R-YTSTTEIL KATLIHQSITGLYETRIDLSKL— 1342

EMC03581 1275 LAS- - -SFI NLLTFTAIGAP-ATFKFFD- KNI- -DRK- R-YTSTTEIL NATLIHQSITGLYETRIDLSKL— 1335

WP 000428612 1310 LAN- - -SFI NLLTFTALGAP-AAFKFFG- KDV- -DRK- R-YTTVSEIL NATLIHQSITGLYETRIDLSKL— 1370

WP 000428613 1308 LAN- - -SFI NLLTFTALGAP-AAFKFFG- KDI- -DRK- R-YTTVSEIL NATLIHQSITGLYETRIDLSKL— 1368

WP 049523028 1303 IAN- - -SFI NLLTFTAFGAP-AVFKFFG- KDI- -ERK- R-YSTVTEIL KATLIHQSLTGLYETRIDLSKL— 1363

WP 003107102 1275 -AT- - -NML NLFTFTGLGAP-ATLKFFN- VDI—DRK R-YTSSTEIL NSTLIRQSITGLYETRIDLSKI— 1334

WP 054279288 1304 -SI- - -SFL NLFKFTSFGAP-EKFTFLN- SEIkqDDV R-YRSTKECL NSTLIHQSVTGLYETRIDLSQF— 1365

WP 049531101 1311 LSE- - -SFI SLLKLTSFGAP-GAFRFLG- ^■VEI- SQSnvR-YQSVSSCF NATLIHQSITGLYETRIDLSKL— 1373

WP 049538452 1311 LSE- - -SFI SLLKLTSFGAP-GAFKFLG- ^■VEI- SQSsvR-YKPNSQFL DATLIHQSITGLYETRIDLSKL— 1373

WP 049549711 1313 LSE- - -SFI SLLKLTSFGAP-GAFKFLG- AEI- SQSsvR-YKPNSQFL DTTLIHQSITGLYETRIDLSKL— 1375

WP 007896501 1312 -AL- - -NML NLFIFTSLGAP-STFVFFD- ^■ETI- -DRK- R-YTTSSDVL NGILIQQSITGLYETRIDLSRF— 1371

EFR44625 1264 -AL- -NML NLFIFTSLGAP-STFVFFD- ^■ETI- -DRK- R-YTTSSDVL NGILIQQSITGLYETRIDLSRF— 1323

WP 002897477 1307 LAN- - -SFI NLLTFTALGAP-AAFKFFG- KDV DRK—R-YTTVSEIL NATLIHQSITGLYETRIDLSKL— 1367

WP 002906454 1312 LSE- - -SFI SLLKLTSFGAP-GAFKFLG- ^■VEI- SQSsvR-YKPNSQFL DTTLIHQSITGLYETRIDLSKL— 1374

WP 009729476 1308 LAN- - -SFI NLLTFTALGAP-AAFKFFG- KDV DRK—R-YTTVSEIL NATLIHQSITGLYETRIDLSKL— 1368

CQR24647 1296 LAQ- - -SFI SLLKFTAFGAP-GGFKFLD- ADI- KQSnlR-YQTVTEVL SSTLIHQSVTGLYETRIDLSKL— 1358

WP 000066813 1312 LAN- - -SFI NLLTFTALGAP-AAFKFLG- KDV DRK—R-YTTVSEIL NATLIHQSITGLYETRIDLSKL— 1372

WP 009754323 1308 LAN- - -SFI NLLTFTALGAP-AAFKFFG- KDV -DRK- R-YTTVSEIL NATLIHQSITGLYETRIDLSKL— 1368

WP 044674937 1301 LTS- - -SFV NLLTFTAIGAP-AAFKFLG- ^■SVI- -DRK- R-YTSIAEIL EATLIHQSVTGLYETRIDLSKL— 1361

WP 044676715 1303 LTS- - -SFV NLLTFTAIGAP-AAFKFLG- ^■SVI- -DRK- R-YTSIAEIL EATLIHQSVTGLYETRIDLSKL— 1363

WP 044680361 1303 LTS- - -SFV NLLTFTAIGAP-AAFKFLG- ^■SVI- -DRK- R-YTSIAEIL EATLIHQSVTGLYETRIDLSKL— 1363

WP 044681799 1301 LTS- - -SFV NLLTFTAIGAP-AAFKFLG- SVI- -DRK- R-YTSIAEIL EATLIHQSVTGLYETRIDLSKL— 1361

WP 049533112 1314 ICT- - -SFL GLFELTSLGSA-SDFEFLG- ^■VKI- -PRY- RdYTPSSLLK DSTLIHQSITGLYETRIDLSKL— 1383

WP 029090905 1241 -VK- - —VI ELLKITQANATnGDLKLLK- ^.— -sNREg -R- ^■LGSVSVAL DFKIINQSVTGLYQSIEDYNN 1300

WP 006506696 1269 -AN- - —II QMLIVMHRGPQnGNIVYDDf -KI-sDRIg -R- ^■LKTKNHNL NIVFISQSPTGIYTKKYKL 1329

AIT42264 1306 -AE- - -Nil HLFTLTNLGAP-AAFKYFD- ^■TTI- -DRK- -R- ^■YTSTKEVL DATLIHQSITGLYETRIDLSQL— 1365

WP 034440723 1277 LVE- - -SFI NLLAITKCGPA-ADITFLG- ΈΚΙ- -SRK- -R- ^■YRSTNCLW GSEVI FQSPTGLYETRLRLE 1335

AKQ21048 1306 -AE- - -Nil HLFTLTNLGAP-AAFKYFD- ^■TTI- -DRK- -R- ^■YTSTKEVL DATLIHQSITGLYETRIDLSQL— 1365

WP 004636532 1272 TVE- - -SFV NLMTFTAMGAP-ATFKFYG- ^■ESI- -TRS- -R- ^■YTSITEFR GSTLIFQSITGLYETRYKL 1329

WP 002364836 1278 IAA- - -SFI QLMQFNAMGAP-STFKFFQ- ^■KDI- -ERA- -R- ^■YTSIKEIF DATIIYQSTTGLYETRRKV 1335

WP 016631044 1229 IAA- - -SFI QLMQFNAMGAP-STFKFFQ- ^■KDI- -ERA- -R- ^■YTSIKEIF DATIIYQSPTGLYETRRKV 1286

EMS75795 1014 LSQ- - -SFI NLMQLNAMGAP-ADFKFFD- ^■VII- -PRK- -R- ^■YPSLTEIW ESTIIYQSITGLRETRTRMATLwd 1076

WP 002373311 1278 IAA- - -SFI QLMQFNAMGAP-STFKFFQ- ^■KDI- -ERA- -R- ^■YTSIKEIF DATIIYQSTTGLYETRRKV 1335

WP 002378009 1278 IAA- - -SFI QLMQFNAMGAP-STFKFFQ- ^■KDI- -ERA- -R- ^■YTSIKEIF DATIIYQSTTGLYETRRKV 1335

WP 002407324 1278 IAA- - -SFI QLMQFNAMGAP-STFKFFQ- ^■KDI- -ERA- -R- ^■YTSIKEIF DATIIYQSTTGLYETRRKV 1335

WP 002413717 1278 IAA- - -SFI QLMQFNAMGAP-STFKFFQ- ^■KDI- -ERA- -R- ^■YTSIKEIF DATIIYQSTTGLYETRRKV 1335

WP 010775580 1280 IAA- - -SFI QLMQFNAMGAP-STFKFFQ- ^■KDI- -ERA- -R- ^■YTSIKEIF DATIIYQSTTGLYETRRKV 1337

WP 010818269 1278 IAA- - -SFI QLMQFNAMGAP-STFKFFQ- ^■KDI- -ERA- -R- ^■YTSIKEIF DATIIYQSTTGLYETRRKV 1335

WP 010824395 1278 IAA—-SFI QLMQFNAMGAP--STFKFFQ--KDI- -ERA- YTSIKEIF DATIIYQSTTGLYETRRKV 1335

WP 016622645 1278 IAA— -SFI QLMQFNAMGAP- -STFKFFQ- -KDI- -ERA- YTSIKEIF DATIIYQSTTGLYETRRKV 1335

WP 033624816 1278 IAA— -SFI QLMQFNAMGAP^■ -STFKFFQ- -KDI- -ERA- YTSIKEIF DATIIYQSTTGLYETRRKV 1335

WP 033625576 1278 IAA— -SFI QLMQFNAMGAP^■ -STFKFFQ- -KDI- -ERA- YTSIKEIF DATIIYQSTTGLYETRRKV 1335

WP 033789179 1278 IAA— -SFI QLMQFNAMGAP^■ -STFKFFQ- -KDI- -ERA- YTSIKEIF DATIIYQSTTGLYETRRKV 1335

WP 002310644 1280 LAS— -SFV NLMQFNAMGAP^■ -ADFKFFD- -V I- -PRK- YTSLTEIW QSTIIHQSITGLYETRIRMGK 1339

WP 002312694 1281 LAS— -SFV NLMQFNAMGAP^■ -ADFKFFD- -V I- -PRK- YTSLTEIW QSTIIHQSITGLYETRIRMGK 1340

WP 002314015 1281 LAS— -SFV NLMQFNAMGAP^■ -ADFKFFD- -V I- -PRK- YTSLTEIW QSTIIHQSITGLYETRIRMGK 1340

WP 002320716 1281 LAS— -SFV NLMQFNAMGAP^■ -ADFKFFD- -V I- -PRK- YTSLTEIW QSTIIHQSITGLYETRIRMGK 1340

WP 002330729 1280 LAS— -SFV NLMQFNAMGAP^■ -ADFKFFD- -VTI- -PRK- YTSLTEIW QSTIIHQSITGLYETRIRMGK 1339

WP 002335161 1281 LAS— -SFV NLMQFNAMGAP^■ -ADFKFFD- -VTI- -PRK- YTSLTEIW QSTIIHQSITGLYETRIRMGK 1340

WP 002345439 1281 LAS— -SFV NLMQFNAMGAP^■ -ADFKFFD- -VTI- -PRK- YTSLTEIW QSTIIHQSITGLYETRIRMGK 1340

WP 034867970 1271 IAQ— -SFL QLLQFNAIGAP- -ADFKFFG- -VTI- -PRK- YTSLTEIW DATIIYQSVTGLYETRIRMGDLwa 1333

WP 047937432 1281 LAS— -SFV NLMQFNAMGAP^■ -ADFKFFD- -VTI- -PRK- YTSLTEIW QSTIIHQSITGLYETRIRMGK 1340

WP 010720994 1271 IAQ— -SFL QLLQFNAIGAP- -ADFKFFG- -VTI- -PRK- YTSLTEIW DATIIYQSVTGLYETRIRMGDLwa 1333

WP 010737004 1271 IAQ— -SFL QLLQFNAIGAP- -ADFKFFG- -VTI- -PRK- YTSLTEIW DATIIYQSVTGLYETRIRMGDLwa 1333

WP 034700478 1271 IAQ— -SFL QLLQFNAIGAP- -ADFKFFG- -VTI- -PRK- YTSLTEIW DATIIYQSVTGLYETRIRMGDLwa 1333

WP 007209003 1270 IAK— -SFI NLLTFTAMGAP- -ADFEFFG- -EKI- -PRK- YVSISEII DAVFIHQSITGLYETRVRLTEV— 1330

WP 023519017 1265 MID— -AIL SLLKFTLFGAS- -VEFKFFD- -IKI- —LK- YKSLTDIW EATIIYQSVTGLYERRVEVRKLwd 1326

WP 010770040 1275 IAE— -SFV NLMKFSAYGAP- -MDFKFFG- -KTI- -PRS- YTSVGELL SATIINQSITGLYETRRKL 1332

WP 048604708 1271 IAQ— -SFV DLMQLNAFGAP- -ADFKFFG- -ETI- -PRK- YTSVNELL EATIINQSITGLYETRRRL 1328

WP 010750235 1274 MAH— -SFV NLMQFNALGAP- -ADFKFFD- -TTI- -TRK- YTSLTEIW QSTIIYQSVTGLYETRRRMADLwd 1336

AII16583 1345 -AE— -Nil HLFTLTNLGAP- -AAFKYFD- -TTI- -DRK- YTSTKEVL DATLIHQSITGLYETRIDLSQL— 1404

WP 029073316 1283 -CE— —VI QMLWMHAGPQnGNITFDDf —KL- sNRLg LNCKTISL TTVFIADSPTGMYSKKYKL 1343

WP 031589969 1284 -CN— —II QILATLHCNSSiGKIMYSDf —KI- sTTIg LNGRTISL DISFIAESPTGMYSKKYKL 1344

KDA45870 1254 LGK— -NFV ELLRYTADGAA- -SDFKFFG- -ENI- -PRK- YNSAGSLL NGTLIYQSKTGLYETRIDLGKL— 1314

WP 039099354 1307 ILDr- V -LIGLHANAAV -SDLGVLKisTPL- -GKM- —QPSGIS DTQIIYQSPTGLFERRVALRDL— 1368

AKP02966 1297 INS1-eELI TLLHANSTSAH- -LIFNNIE-kKAF- -GRK- THGLT DTDFIYQSVTGLYETRIHIE 1356

WP 010991369 1275 IAQ— -SFV DLMAFNAMGAP- -ASFKFFE- -TTI- -ERK- YNNLKELL NSTIIYQSITGLYESRKRL 1332

WP 033838504 1275 IAQ— -SFV DLMAFNAMGAP- -ASFKFFE- -TTI- -ERK- YNNLKELL NSTIIYQSITGLYESRKRL 1332

EHN60060 1278 IAQ— -SFV DLMAFNAMGAP- -ASFKFFE- -TTI- -ERK- YNNLKELL NSTIIYQSITGLYESRKRL 1335

EFR89594 1044 IAQ— -SFV DLMAFNAMGAP- -ASFKFFE- -TTI- -ERK- YNNLKELL NSTIIYQSITGLYESRKRL 1101

WP 038409211 1275 IAK— -SFD KLKVFNAFGAP- -RDFEFFE- -TTI- -KRK- YYNIKELL NATIIYQSITGLYEARKRL 1332

EFR95520 894 IAK— -SFD KLKVFNAFGAP- -RDFEFFE- -TTI- -KRK- YYNIKELL NATIIYQSITGLYEARKRL 951

WP 003723650 1275 IAQ— -SFV DLMAFNAMGAP- -ASFKFFE- -ATI- -DRK- YTNLKELL SSTIIYQSITGLYESRKRL 1332

WP 003727705 1275 IAQ— -SFV DLMAFNAMGAP- -ASFKFFE- -ATI- -DRK- YTNLKELL SSTIIYQSITGLYESRKRL 1332

WP 003730785 1275 IAQ— -SFV DLMAFNAMGAP- -ASFKFFE- -ATI- -DRK- YTNLKELL SSTIIYQSITGLYESRKRL 1332

WP 003733029 1275 IAE— -SFV SLKKFNAFGVH- -QDFSFFG- -TKI- -ERK- DRKLNELL NSTIIYQSITGLYESRKRL 1332

WP 003739838 1275 IAQ— -SFV NLMAFNAMGAP- -ASFKFFE- -ATI- -ERK- YTNLKELL SATIIYQSITGLYEARKRL 1332

7

WP 014601172 1275 IAQ-—SFV DLMAFNAMGAP--ASFKFFE--ATI--DRK--R-^■YTNLKELL SSTIIYQSITGLYESRKRL 1332

WP 023548323 1275 IAE- —SFV SLKKFNAFGVH- -KDFNFFG- -TTI- -KRK - -R- ^■DRKLKELL NSTIIYQSITGLYESRKRL 1332

WP 031665337 1275 IAQ- —SFV DLMAFNAMGAP- -ASFKFFE- -ATI- -DRK - -R- ^■YTNLKELL SSTIIYQSITGLYESRKRL 1332

WP 031669209 1275 IAE- —SFV SLKKFNAFGVH- -QDFSFFG- -TKI- -ERK - -R- ^■DRKLNELL NSTIIYQSITGLYESRKRL 1332

WP 033920898 1275 IAE- —SFV SLKKFNAFGVH- -KDFNFFG- -TTI- -KRK - -R- ^■DRKLKELL NSTIIYQSITGLYESRKRL 1332

AKI42028 1278 IAQ- —SFV DLMAFNAMGAP- -ASFKFFE- -ATI- -DRK - -R- ^■YTNLKELL SSTIIYQSITGLYESRKRL 1335

AKI50529 1278 IAE- —SFV SLKKFNAFGVH- -KDFNFFG- -TTI- -KRK - -R- ^■DRKLKELL NSTIIYQSITGLYESRKRL 1335

EFR83390 723 IAQ- —SFV DLMVFNAMGAP- -ASFKFFE- -ATI- -DRK - -R- ^■YTNLKELL SSTIIYQSITGLYESRKRL 780

WP 046323366 1275 IAQ- —SFV NLLEFNAMGAP- -ASFKYFE- -TNI- -ERK - -R- ^■YNNLKELL NATIIYQSITGLYEARKRL 1332

AKE81011 1322 -AE- —Nil HLFTLTNLGAP- -AAFKYFD- -TTI- -DRK - -R- ^■YTSTKEVL DATLIHQSITGLYETRIDLSQL— 1381

CU082355 1273 -AN- VI QMLIIMHKGPQnGNIIYDDf —NV-gKRIg -R- ^■LNGRTFYL NIEFISQSPTGIYTKKYKL 1333

WP 033162887 1275 -CD- VI QILIIMHAGPMnGNIMYDDf —KF-tNRIg -R- ^■FTHKNIDL KTTFISTSVTGLFSKKYKL 1335

AGZ 01981 1339 -AE- —Nil HLFTLTNLGAP- -AAFKYFD- -TTI- -DRK - -R- ^■YTSTKEVL DATLIHQSITGLYETRIDLSQL— 1398

AKA60242 1306 -AE- —Nil HLFTLTNLGAP- -AAFKYFD- -TTI- -DRK - -R- ^■YTSTKEVL DATLIHQSITGLYETRIDLSQL— 1365

AKS40380 1306 -AE- —Nil HLFTLTNLGAP- -AAFKYFD- -TTI- -DRK - -R- ^■YTSTKEVL DATLIHQSITGLYETRIDLSQL— 1365

4UN5 B 1310 -AE- —Nil HLFTLTNLGAP- -AAFKYFD- -TTI- -DRK - -R- ^■YTSTKEVL DATLIHQSITGLYETRIDLSQL— 1369

WP 010922251 1366 GGD 1368

WP ^"039695303 1370 GEE 1372

WP ^"045635197 1368 GED 1370

5AXW A

WP 009880683 1050 GGD 1052

WP ^"010922251 1366 GGD 1368

WP ^"011054416 1366 GGD 1368

WP ^"011284745 1366 GGD 1368

WP ^"011285506 1366 GGD 1368

WP ^"011527619 1366 GGD 1368

WP ^"012560673 1366 GGD 1368

WP ^"014407541 1365 GGD 1367

WP ^"020905136 1366 GGD 1368

WP ^"023080005 1365 GGD 1367

WP ^"023610282 1365 GGD 1367

WP ^"030125963 1366 GGD 1368

WP ^"030126706 1366 GGD 1368

WP ^"031488318 1366 GGD 1368

WP ^"032460140 1366 GGD 1368

WP ^"032461047 1366 GGD 1368

WP ^"032462016 1366 GGD 1368

WP ^"032462936 1366 GGD 1368

WP ^"032464890 1366 GGD 1368

WP ^"033888930 1191 GGD 1193

WP ^"038431314 1366 GGD 1368

WP ^"038432938 1365 GGD 1367

WP ^"038434062 1366 GGD 1368

BAQ51233 1277 GGD 1279

KGE60162 541 GGD 543

KGE60856 304 GGD 306

WP 002989955 1366 GGD 1368

WP ^"003030002 1343 GED 1345

WP ^"003065552 1371 GEE 1373

WP ^"001040076 1368 GED 1370

WP ^"001040078 1376 GED 1378

WP ^"001040080 1368 GED 1370

WP ^"001040081 1368 GED 1370

WP ^"001040083 1368 GED 1370

WP ^"001040085 1368 GED 1370

WP 001040087 1368 GED 1370

WP ^"001040088 1368 GGD 1370

WP ^"001040089 1368 GED 1370

WP ^"001040090 1368 GED 1370

WP ^"001040091 1368 GED 1370

WP ^"001040092 1368 GED 1370

WP ^"001040094 1368 GED 1370

WP ^"001040095 1368 GEG 1370

WP ^"001040096 1368 GEG 1370

WP ^"001040097 1368 GED 1370

WP ^"001040098 1368 GED 1370

WP ^"001040099 1368 GED 1370

WP ^"001040100 1368 GED 1370

WP ^"001040104 1368 GED 1370

WP ^"001040105 1368 GED 1370

WP ^"001040106 1368 GED 1370

WP ^"001040107 1368 GED 1370

WP ^"001040108 1368 GED 1370

WP ^"001040109 1368 GED 1370

WP ^"001040110 1368 GED 1370

WP ^"015058523 1368 GED 1370

WP ^"017643650 1368 GED 1370

WP ^"017647151 1368 GED 1370

WP ^"017648376 1368 GED 1370

WP ^"017649527 1368 GED 1370

WP ^"017771611 1368 GED 1370

WP ^"017771984 1368 GED 1370

CFQ25032 1368 GED 1370

CFV16040 1368 GED 1370

KLJ37842 1368 GED 1370

KLJ72361 1368 GGD 1370

KLL20707 1382 GED 1384

KLL42645 1368 GED 1370

WP 047207273 1368 GED 1370

WP ^"047209694 1368 GED 1370

WP ^"050198062 1368 GED 1370

WP ^"050201642 1368 GED 1370

WP ^"050204027 1368 GED 1370

WP ^"050881965 1368 GED 1370

WP 050886065 1368 GED 1370

AHN30376 1368 GED 1370

EA078426 1368 GED 1370

CCW42055 1368 GED 1370

WP 003041502 1384 GED 1386

WP 037593752 1344 GED 1346

WP 049516684 1344 GED 1346

GAD46167 1343 GED 1345

WP 018363470 1375 GEE 1377

WP 003043819 1373 GGD 1375

WP 006269658 1343 GED 1345

WP 048800889 1363 GED 1365

WP 012767106 1369 GGD 1371

WP 014612333 1369 GGD 1371

WP 015017095 1369 GGD 1371

WP 015057649 1369 GGD 1371

WP 048327215 1369 GGD 1371

WP 049519324 1369 GGD 1371

WP 012515931 1346 GEN 1348

WP 021320964 1346 GEN 1348

WP 037581760 1346 GEN 1348

WP 004232481 1375 GEE 1377

WP 009854540 1368 GEE 1370

WP 012962174 1369 GEE 1371

WP 039695303 1370 GEE 1372

WP 014334983 1373 GEE 1375

WP 003099269 1366 GGK 1368

AHY15608

AHY17476

ESR09100 198 GGK 200

AGM98575

ALF27331 1343 GGD 1345

WP 018372492 1351 GEN 1353

WP 045618028 1374 GED 1376

WP 045635197 1368 GED 1370

WP 002263549 1343 GGD 1345

WP 002263887 1343 GGD 1345

WP 002264920 1343 GGD 1345

WP 002269043 1343 GGD 1345

WP 002269448 1343 GGD 1345

WP ^"002271977 1343 GGD 1345

WP ^"002272766 1343 GGD 1345

WP ^"002273241 1343 GGD 1345

WP ^"002275430 1343 GGD 1345

WP ^"002276448 1343 GGD 1345

WP ^"002277050 1353 GGD 1355

WP ^"002277364 1343 GGD 1345

WP ^"002279025 1343 GGD 1345

WP ^"002279859 1343 GGD 1345

WP ^"002280230 1343 GGD 1345

WP ^"002281696 1343 GGD 1345

WP ^"002282247 1353 GGD 1355

WP ^"002282906 1343 GGD 1345

WP ^"002283846 1343 GGD 1345

WP ^"002287255 1343 GGD 1345

WP ^"002288990 1343 GGD 1345

WP ^"002289641 1343 GGD 1345

WP ^"002290427 1343 GGD 1345

WP ^"002295753 1343 GGD 1345

WP ^"002296423 1343 GGD 1345

WP ^"002304487 1357 GGD 1359

WP ^"002305844 1343 GGD 1345

WP ^"002307203 1343 GGD 1345

WP ^"002310390 1343 GGD 1345

WP ^"002352408 1343 GGD 1345

WP ^"012997688 1343 GGD 1345

WP ^"014677909 1343 GGD 1345

WP ^"019312892 1343 GGD 1345

WP ^"019313659 1343 GGD 1345

WP ^"019314093 1343 GGD 1345

WP ^"019315370 1343 GGD 1345

WP ^"019803776 1343 GGD 1345

WP ^"019805234 1343 GGD 1345

WP ^"024783594 1343 GGD 1345

WP ^"024784288 1353 GGD 1355

WP ^"024784666 1343 GGD 1345

WP ^"024784894 1343 GGD 1345

WP ^"024786433 1353 GGD 1355

WP 049473442 1343 GGD 1345

WP ^"049474547 1343 GGD 1345

EMC03581 1336 GGD 1338

WP 000428612 1371 GED 1373

WP ^"000428613 1369 GED 1371

WP ^"049523028 1364 GEE 1366

WP ^"003107102 1335 GGD 1337

WP ^"054279288 1366 GGD 1368

WP ^"049531101 1374 GED 1376

WP ^"049538452 1374 GED 1376

WP ^"049549711 1376 GED 1378

WP ^"007896501 1372 GGD 1374

EFR44625 1324 GGD 1326

WP 002897477 1368 GEE 1370

WP ^"002906454 1375 GED 1377

WP ^"009729476 1369 GED 1371

CQR24647 1359 GGE 1361

WP 000066813 1373 GED 1375

WP ^"009754323 1369 GED 1371

WP ^"044674937 1362 GGD 1364

WP ^"044676715 1364 GGD 1366

WP ^"044680361 1364 GGD 1366

WP ^"044681799 1362 GGD 1364

WP ^"049533112 1384 GED 1386

WP ^"029090905

WP ^"006506696

AIT42264 1366 GGD 1389

WP 034440723

AKQ21048 1366 GGD 1384

WP 004636532 1330 -ED 1332

WP ^"002364836 1336 -VD 1337

WP ^"016631044 1287 -VD 1288

EMS75795 1077 GEQ 1079

WP 002373311 1336 -VD 1337

WP ^"002378009 1336 -VD 1337

WP ^"002407324 1336 -VD 1337

WP ^"002413717 1336 -VD 1337

WP ^"010775580 1338 -VD 1339

WP ^"010818269 1336 -VD 1337

WP 010824395 1336 -VD 1337

WP ^"016622645 1336 -VD 1337

WP ^"033624816 1336 -VD 1337

WP ^"033625576 1336 -VD 1337

WP ^"033789179 1336 -VD 1337

WP ^"002310644

WP ^"002312694

WP ^"002314015

WP ^"002320716

WP ^"002330729

WP ^"002335161

WP ^"002345439

WP ^"034867970 1334 GEQ 1336

WP ^"047937432

WP ^"010720994 1334 GEQ 1336

WP ^"010737004 1334 GEQ 1336

WP ^"034700478 1334 GEQ 1336

WP ^"007209003

WP ^"023519017 1327 GER 1330

WP ^"010770040 1333 -VD 1334

WP ^"048604708 1329 -GD 1330

WP ^"010750235 1337 GVQ 1339

AII16583 1405 GGD 1424

WP 029073316

WP ^"031589969

KDA45870

WP 039099354

AKP02966

WP 010991369 1333 -DD 1334

WP ^"033838504 1333 -DD 1334

EHN60060 1336 -DD 1337

EFR89594 1102 -DD 1103

WP 038409211 1333 -ED 1334

EFR95520 952 -ED 953

WP 003723650 1333 -DD 1334

WP ^"003727705 1333 -DD 1334

WP ^"003730785 1333 -DD 1334

WP ^"003733029 1333 -DN 1334

WP ^"003739838 1333 -DG 1334

WP 014601172 1333 -DD 1334

WP_023548323 1333 -DS 1334

WP 031665337 1333 -DD 1334

WP 031669209 1333 -DN 1334

WP_033920898 1333 -DS 1334

AKI42028 1336 -DD 1337

AKI50529 1336 -DS 1337

EFR83390 781 -DD 782

WP_046323366 1333 -DD 1334

AKE81011 1382 GGD 1400

CU082355

WP_033162887

AGZ 01981 1399 GGD 1417

AKA60242 1366 GGD 1368

AKS40380 1366 GGD 1376

4UN5 B 1370 GGD 1372

[00253] Additional suitable Cas9 sequences in which amino acid residues homologous to residues 10, 122, 137, 182, 262, 294, 409, 480, 543, 660, 694, 840, 1219, and/or 1329 of SEQ ID NO: 9 can be identified are known to those of skill in the art. See, e.g.,

Supplementary Table S2 and Supplementary Figure S2 of Fonfara et al., Phylogeny of Cas9 determines functional exchangeability of dual-RNA and Cas9 among orthologous type II CRISPR-Cas systems, Nucl. Acids Res. 2013, doi: 10.1093/nar/gktl074, which are incorporated herein by reference in their entirety. Cas9 variants of the sequences provided herein or known in the art comprising one or more mutations, e.g., at least one, at least two, at least three, at least four, at least five, at least six, or at least seven mutations as provided herein, e.g., of one or more amino acid residue that is homologous to amino acid residue 10, 122, 137, 182, 262, 294, 409, 480, 543, 660, 694, 840, 1219, and/or 1329 in SEQ ID NO: 9 are provided by this disclosure, for example, Cas9 variants comprising a A262T, K294R, S409I, E480K, E543D, M694I, and/or E1219V mutation.

EXAMPLE 4: Evolution of Cas9 With Broadened PAM Specificities

[00254] By evolving S. pyogenes Cas9 on a NNN PAM library using PACE, Cas9s with broadened PAM specificities have been evolved with higher activities for many non- canonical PAMs. Such a Cas9 still retains its native DNA binding and cutting activity and can be utilized with all of the current tools available. It has been hypothesized that by modulating Cas9's interactions with the DNA, the PAM specificity of Cas9 can be modified and expanded. Other Cas9s such as Staphylococcus aureus could also be engineered to change and expand their PAM specificity by such a method. Methods to modulate DNA binding such as targeted mutagenesis of the Cas9 protein, fusions to DNA-binding proteins, and the use of multiple Cas9 proteins tethered to each other could also expand the PAMs that can be targeted.

[00255] Cas9 Evolution. After evolution using overnight propagation of the phage with the mutagenesis plasmid (MP), the resultant phages containing mutations, discussed above, in PACE were used. Twenty-four individual phages were sequenced from the PACE run. Mutations found in the Cas9 gene are documented in Table 3 below. The Cas9 gene containing these mutations was cloned out of the phage and into plasmids to test both DNA binding and cutting activity. Table 3 : Cas9 mutations

pJH306

(WT

dCas9- VPR)

pJH407

(WT

Cas9)

pJH562

(dCas9- VPR) E480K E543D E1219V

pJH599

(dCas9- VPR) A262T S409I E480K E543D M694I E1219V

pJH600

(dCas9- VPR) K294R E480K E543D E1219V Q1256K L1362P pJH601

(dCas9- VPR) A262T S409I E480K E543D M694I E1219V

pJH602

(dCas9- VPR) K294R E480K E543D E1219V Q1256K pJH603

(dCas9- VPR) A262T S409I E480K E543D M694I E1219V

pJH604

(dCas9- VPR) S267G K294R E480K E543D E1219V N1224K Q1256K pJH605

(dCas9- VPR) A262T F405I S409I E480K E543D M694I E1219V

pJH760

(pJH599

Minus

VPR,

Nucleas

e

Positive

A262T S409I E480K E543D M694I E1219V

[00256] GFP Activation in Human Cell Culture. Testing was performed on a

reporter with a GFP reporter activated by dCas9-VPR. Testing was performed on 5'-NGG-3' PAM first (Figures 4A and 4B) and then with a library of GFP reporters all containing the same Cas9 target site, but with N N at the PAM position (Figures 5A and 5B). In this

testing, dCas9-VPR was found to activate the GFP signal. Wild-type Cas9 with no mutations (pJH306), Cas9 evolved from overnight propagation (pJH562), and Cas9 evolved from

PACE (pJH599-pJH605) were all tested. Mutations for each Cas9 are documented in Table 3 above.

[00257] dCas9-VPR on all 64 PAM Sequences. pJH306 (WT dCas9-VPR) and pJH599 (WT dCas9-VPR with mutations A262T, S409I, E480K, E543D, M694I, and E1219V) were tested on all 64 PAM sequences (Figure 6). dCas9-VPR was used to activate GFP as before and a different reporter plasmid was used for each well to ascertain the activation efficiency for all 64 different PAM sequences. The mean GFP fluorescence was measured for all transfected cells, as gated by iRFP signal. pJH599 showed either improved or similar levels of activation as compared to pJH306 for all PAM sequences.

[00258] In Vitro Cutting Assay. The ability of expressed and purified WT Cas9 (WT) and Cas 9 with an E1219V mutation (1) to cut DNA with different PAMs was tested (Figure 7). Cas9 was incubated with dsDNA containing the target site. Cutting was measured by running the DNA on a gel to compare the amount of uncut product to the amount of cut products, which run faster due to their smaller size. The E1219V mutation was found to increase Cas9 cutting activity on non-canonical PAMs while maintaining activity on 5 '-NOGS ' PAMs.

[00259] Evolving Different Systems. In addition to S. pyogenes Cas9 evolution, other

Cas9 systems such as S. aureus, S. thermophilus, N. meningitidis, and T. denticola, etc. can be evolved to modify and expand their PAM specificities. The data indicates that, by using a similar system to the S. pyogenes Cas9 evolution, a phage containing the S. aureus Cas9 can also be evolved to expand its PAM specificity.

[00260] Modulating PAM Specificity. By mutating neutral and negatively charged amino acids to positively charged amino acids, Cas9 could be modified to expand the PAMs that can be targeted. Generally, incorporating mutations into Cas9 proteins that generate a net increase in positive charge may increase the affinity of Cas9 to bind DNA. In

combination with the Cas9 mutations provided herein, additional residues that could be mutated for increased PAM targeting in S. pyogenes Cas9 further include ones that have been identified to change the PAM specificity (D1135, G1218, R1333, R1335, T1337)³⁸ and residues that can increase Cas9 activity (S845 and L847) ³⁷. Residues that increase Cas9 specificity such as the mutations of arginine, histidine, and lysine to alanine previously identified³⁷ and the mutations of asparagine, arginine, and glutamine to alanine as previously identified³⁹ could lead to lower tolerability for non-canonical PAMs as these mutations presumably decrease the interactions between the Cas9 and DNA.

[00261] Fusions to Modulate PAM Specificity. Programmable DNA-binding proteins such as zinc-finger domains, TALEs, and other Cas9 proteins could be fused to Cas9 to improve the ability to target nucleotide sequences having canonical or non-canonical PAMs, for example to increase activity, specificity or efficiency. A nuclease-null dCas9 could be fused to a nuclease active Cas9 to increase the ability of the nuclease active Cas9 to target different PAM sequences. One example of a nuclease-null dCas9 fused to a nuclease active Cas9 is shown in Figure 8. Such fusions can be useful for improving the ability to target nucleotide sequences having canonical or non-canonical PAMs. The Cas9s could either be from the same species or from different species. Furthermore, both Cas9s could be nuclease- null dCas9, and could be further fused to effector proteins such as VP64, VP64-p65-Rta, Fokl, GFP and other fluorescent proteins, deaminases, or any of the effector proteins provided herein.

[00262] Using Cas9 to Localize Other Nucleases and Other DNA-Binding

Proteins. Cas9 can also be used to overcome the native binding specificity of other proteins by localizing them to their DNA targets. DNA nucleases, recombinases, deaminases, and other effectors often have a native DNA specificity. Cas9 can be fused to these proteins to overcome and expand their native DNA specificities. gRNAs will target the Cas9 adjacent to the DNA effector's target site and will help to localize them to their target site.

[00263] dCas9-VPR on NNNNN PAM Library. To test that the evolved Cas9s had not picked up specificity in the 4th and 5th PAM positions, dCas9-VPR on a NNNNN PAM library was tested. As seen with the NNN library, most of the constructs (e.g., pJH562, pJ559, pJH600, pJH601, pJH602, pJH603, and pJH605) showed improved activity. pJH599 consistently showed improvement in both the percentage of cells that showed GFP activation (Figure 9A) and the mean fluorescence of those cells that showed GFP activation (Figure 9B).

[00264] Cas9 GFP Cutting. The WT Cas9, pJH407, was compared with a nuclease- positive evolved Cas9, pJH760 (Figure 10). pJH760 contained the same mutations as pJH599 but without the D10A and H480A nuclease-inactivating mutations, and without the VPR fusion. A genomically integrated GFP gene was cut by Cas9 and the activity was measured by the loss of GFP signal in cells. On a site with 5'-NGG-3' PAM, pJH407 and pJH760 showed comparable activity. On a site with GAT PAM, pJH760 showed a significant increase in activity as compared to pJH407.

EXAMPLE 5 Cas9:DNA Editing Enzyme Fusion Proteins

[00265] This disclosure further provides Cas9 fused with a DNA editing enzyme for the targeted editing of DNA sequences. Figure 11 illustrates double stranded DNA substrate binding by DNA editing enzyme-dCas9:sgRNA complexes. The DNA editing enzyme shown is a deaminase. The structures according to Figure 11 are identified in these sequences (36bp: underlined, sgRNA target sequence: bold; PAM: boxed; 21bp: italicized). EXAMPLE 6 PAM Depletion Assay

[00266] In E. coli, a library of PAM sequences are encoded in a plasmid that also contains an antibiotic gene. If the Cas9 can cut the PAM sequences on the plasmid, the plasmid is not replicated and is lost; only plasmids that are uncut remain the population. The plasmids that were cut by the Cas9 can be determined by sequencing the initial plasmid population and the final plasmid population through high throughput sequencing. The proportion of the library consisting of each PAM sequence was obtained by dividing the number of reads containing the PAM sequence by the total number of reads. The depletion score was then calculated by dividing the proportion of the library containing the PAM section before the selection by the proportion of the library containing the PAM sequence after selection. Higher depletion scores signify higher cutting activity by the Cas9 of that particular PAM sequence. The results of the PAM depletion assay are shown in Figure 12.

[00267] A number of PAM sequences that were not cut with the wild-type Cas9 were cut with the evolved Cas9 (xCas9 vl .O, pJH760). Notably, all PAM sequences of the form NGN and NNG, as well as GAA and GAT showed a depletion greater than 10-fold with the xCas9. A single G in either the second or third PAM position could be sufficient for cutting with the newly evolved Cas9, opening up the sequence space significantly for the target sites that can be targeted using Cas9. The PAM depletion scores are given in Table 4.

Table 4. PAM Depletion Scores

TGA 1.72 27.02

GGA 16.03 26.90

AGG 17.80 26.19

TAG 9.54 25.98

CGC 1.76 25.88

AGT 0.97 24.88

CGG 19.03 24.77

AAG 15.40 24.16

GTG 3.76 23.71

ATG 1.26 23.48

GGG 17.59 23.01

TGC 1.71 23.00

TTG 0.98 22.15

GAA 1.04 20.96

AGC 1.43 16.85

GAT 1.02 16.09

CTG 1.29 13.88

CCG 1.02 11.86

CAT 0.99 5.75

CAA 1.00 5.28

GAC 0.98 3.96

TAA 0.97 1.90

AAA 1.02 1.81

TAT 0.95 1.56

CAC 1.01 1.48

GTA 0.94 1.42

AAT 0.98 1.39

GCA 0.98 1.22

ACA 0.95 1.13

AAC 1.08 1.09

TAC 0.92 0.95

ATA 1.04 0.94

GTC 0.99 0.92

GCT 0.99 0.87

TCA 0.94 0.84 CTA 0.95 0.83

GCC 0.99 0.82

GTT 0.97 0.81

TCC 0.98 0.80

ACC 0.96 0.80

CTC 0.92 0.80

CCA 0.97 0.79

CCC 0.95 0.79

CTT 0.96 0.79

ATC 0.96 0.78

CCT 0.94 0.78

ATT 0.93 0.77

ACT 0.89 0.77

TTT 0.94 0.77

TCT 0.95 0.77

TTC 0.96 0.76

TTA 0.94 0.76

EXAMPLE 7: GFP Cutting Mammalian Cells

[00268] Wild-type or evolved Cas9 and gRNAs were transfected into mammalian cells containing a genomically integrated GFP gene. Different gRNAs targeted different sites with different PAM sequences, such that cutting of the GFP by Cas9 would lead to a loss of the GFP signal. The GFP signal was quantified after five days with flow cytometry. As shown in Figure 13, evolved Cas9 cut GFP in mammalian, in line with the results in the GFP activation assay and in the PAM depletion assay. High throughput sequencing around the cut site verified the results seen with the flow cytometer; the indels were proportional to the cutting percentage seen with the flow cytometer.

EXAMPLE 8: Further Evoluation of the HHH Library

[00269] As SpCas9 has a preference for the G residues at the second and third base, evolutation was continued using the end point from the last evolution on a HHH (H = A, C, or T) PAM library. After evolution, 13 colonies were sequenced and a number of new mutations were identified. Three mutations, the E1219V, E480K, and E543D mutations were found in all the clones. A number of the clones either had the S267G/K294R/Q1256K mutations or the A262T/S409I mutations but those mutations were never seen together, suggesting that the clones had taken two divergent paths along the evolutionsary landscape. The new mutations are given in Table 5.

Table 5. New Mutations

EXAMPLE 9: Further Evolved Cas9 Proteins for Gene Editing

[00270] pJH760, described in Example 6, was tested in the PAM depletion assay on a number of new targets. Four new targets were selected: re2

(GGGGC C AC T AGGG AC AGG AT (SEQ ID NO: 314)), a synthetic target previously used for GFP activation in mammalian cells; VEGF (GGGTGGGGGGAGTTTGCTCC (SEQ ID NO: 315)), a target within the VEGF gene, CLTA (GCAGATGTAGTGTTTCCACA (SEQ ID NO: 316)), a target within the CLTA gene; and CCR5D

(TCACTATGCTGCCGCCCAGT (SEQ ID NO: 317)), a target within the CCR5D gene. The results of the PAM depletion assay are given in Figures 14 to 17. It was found that, in addition to the canonical NGG sequence, PAM depletion demonstrates cutting for most NGN and some NNG sequences as well.

[00271] The HUH PAM library was further evolved using the end point from the last evolution on a HHH (H = A, C, or T) PAM library. After evolution, 13 colonies were sequenced and a number of new mutations were identified. Three mutations, the E1219V, E480K, and E543D mutations were found in all the clones. A number of the clones either had the K294R/Q1256K mutations or the A262T/S409I mutations but those mutations were never seen together, suggesting that the clones had taken two divergent paths along the evolutionsary landscape. The new mutations are given in Tables 8 and 9 below.

[00272] As expected, variation in activity was seen with different targets. The PAM depletion assay scores are given in Table 10. NGN consistently showed cutting activity with some targets. Variation was seen amoungst the xCas9 3.x mutants in terms of which mutant had the best activity. Of note, xCas9 3.3 contained the K294R/Q1256K series of mutations, while the other three mutants (3.6, 3.7, and 3.8) contained the A262T/S409I series of mutations. xCas9 3.6 and 3.7 outperformed 3.8. While 3.3 seemed to have the highest activity for most cases, 3.6 and 3.7 performed better on certain PAM sequences. The results of the PAM depletion assays for three of the new targets described above are given in Figures 18 to 20.

[00273] A NNNNN PAM depletion library was constructed. It was assayed to examine any fourth or fifth base specificity. Initial results of the PAM depletion assay show that there is no preference at the fourth and fifth base as expected.

[00274] In summary, E1219V was found to be one of the earliest mutations that fixed in the evoluation. It is close to the PAM sequence in the crystal structure. E480K and E543D were also seen in all of the clones from the early stages of the evolution, and may be important. K294R/Q1256K and A262T/S409I seem to be two divergent paths, and may be important. Their PAM sequence profiles seem to be slightly different, which implies their importance relative to PAM activity determination.

Table 6 Diseases/disorders containging T to C Changes. The table includes human gene mutations that may be corrected by changing a cytosine (C) to a thymine (T). The gene name, gene symbol, and Gene ID are indicated.

(p.Ser72Pro) AGGCTTTGGAGGAAGTCCTGA']

NM_000398.6(CYB5R3):c.382T ['CAAGTTTCCCGCTGGAGGGAAGATGYCTCA

689 >C (p.Serl28Pro) 1727 CYB5R3 GTACCTGGAGAGCATGCAGAT']

NM_000398.6(CYB5R3):c.446T ['GAGTTCCGGGGCCCCAGTGGGCTGCYGGTC

690 >C (p.Leul49Pro) 1727 CYB5R3 TACCAGGGCAAAGGTGATTCG]

NM_000398.6(CYB5R3):c.610T ['GAAGGACCCTGATGACCACACTGTGYGCCA

691 >C (p.Cys204Arg) 1727 CYB5R3 CCTGCTCTTTGCCAACCAGGT']

NM_000398.6(CYB5R3):c.218T ['CCGTCACCCCAGCACATCCTGGGCCYCCCTG

692 >C (p.Leu73Pro) 1727 CYB5R3 TCGGTGAGTCACGCCCCTGC]

NM_000552.3(VWF):c.4883T>C ['CCTGGAGACATCCAGGTGGTGCCCAYTGGA

693 (p.Ilel628Thr) 7450 VWF GTGGGCCCTAATGCCAACGTG]

NM_000552.3(VWF):c.4837T>C ['CTACATGGTCACCGGAAATCCTGCCYCTGAT

694 (p.Serl613Pro) 7450 VWF GAGATCAAGAGGCTGCCTGG]

NM_000552.3(VWF):c.3814T>C ['GGAACCGCCGTTGCACGATTTCTACBGCAGC

695 (p.Cysl272Arg) 7450 VWF AGGCTACTGGACCTGGTCTT']

NM_000552.3(VWF):c.8317T>C ['CAACGATGTGCAGGACCAGTGCTCCYGCTG

696 (p.Cys2773Arg) 7450 VWF CTCTCCGACACGGACGGAGCC]

NM_000552.3(VWF):c.3445T>C ['TGAGTGTGAGTGGCGCTATAACAGCYGTGC

697 (p.Cysl l49Arg) 7450 VWF ACCTGCCTGTCAAGTCACGTG]

NM_000552.3 (VWF) :c .3178T>C ['GAAGCAGACGATGGTGGATTCCTCCYGTAG

698 (p.Cysl060Arg) 7450 VWF AATCCTTACCAGTGACGTCTT']

NM_001042492.2(NFl):c.5858T ['TGTTTGGAATACATGACTCCATGGCYGTCAA

699 >C (p.Leul953Pro) 4763 NF1 ATCTAGTTCGTTTTTGCAAG]

NM_000267.3(NFl):c.l523T>C ['ATTCATGCAGATCCAAAGCTCTTGCYTTGTG

700 (p.Leu508Pro) 4763 NF1 TAAGTATTTTTTTATGAAAT']

NM_000267.3(NFl):c.6200T>C ['ATTTTAGCACGCTACATGCTGATGCYGTCCT

701 (p.Leu2067Pro) 4763 NF1 TCAACAATTCCCTTGATGTG]

NM_000267.3 (NF 1 ) : c.1070T>C ['CTGTTGGGGTTTTTATAGAACCTGCYTTTTA

702 (p.Leu357Pro) 4763 NF1 ATCCAAGTAAGCCATTCTCA']

NM_000267.3(NFl):c.3728T>C ['TCTCAGGATGAACTAGCTCGAGTTCYGGTTA

703 (p.Leul243Pro) 4763 NF1 CTCTGTTTGATTCTCGGCAT']

NM_000308.2(CTSA):c.247T>C ['CTCCGGCTCCAAGCACCTCCACTACYGGTCT

704 (p.Trp83Arg) 5476 CTSA GCCGCCCTGCCTTCTGGGCG]

NM_001127695.1(CTSA):c.707 ['ATCTCCTACAGGCTTTGGTCTTCTCYCCAGA

705 T>C (p.Leu236Pro) 5476 CTSA CCCACTGCTGCTCTCAAAAC]

NM_000308.2(CTSA):c.l271T> ['GATGTAGACATGGCCTGCAATTTCAYGGGG

706 C (p.Met424Thr) 5476 CTSA GATGAGTGGTTTGTGGATTCC]

NM_000405.4(GM2 A) : c.412T> ['GCGTACCTATGGGCTTCCTTGCCACYGTCCC

707 C (p.Cysl38Arg) 2760 GM2A TTCAAAGAAGTAAGTACTTA']

NM_001165974.1 (UROC 1 ) :c .20 13166 ['CCAGAGTTTGCCCAGGAGCTGCAACYGTAC

708 9T>C (p.Leu70Pro) 9 UROC1 GGACACATCTACATGTACCGG]

NM_003730.4(RNASET2):c.550 ['ATATGGAGTGATACCCAAAATCCAGYGCCT

709 T>C (p.Cysl84Arg) 8635 RNASET2 TCCACCAAGCCAGGTTAGACA']

710 NM_199069.1(NDUFAF3):c.2T 25915 NDUFAF3 ['GACTTCGCCGCGCGTTGGTCAGCCAYGGCC >C (p.MetlThr) ACCGCTCTCGCGCTACGTAGC']

NM_178012.4(TUBB2B):c.514T 34773 ['CATGAACACCTTCAGCGTCATGCCCYCACCC

711 >C (p.Serl72Pro) 3 TUBB2B AAGGTGTCAGACACGGTGGT']

NM_178012.4(TUBB2B):c.683T 34773 ['CCCACCTACGGGGACCTCAACCACCYGGTG

712 >C (p.Leu228Pro) 3 TUBB2B TCGGCCACCATGAGCGGGGTC]

NM_178012.4(TUBB2B):c.793T 34773 ['CATGGTGCCCTTCCCTCGCCTGCACYTCTTC

713 >C (p.Phe265Leu) 3 TUBB2B ATGCCCGGCTTCGCGCCCCT']

NM_000110.3(DPYD):c.85T>C ['TCGAACACAAACTCATGCAACTCTGYGTTCC

714 (p.Cys29Arg) 1806 DPYD ACTTCGGCCAAGAAATTAGA']

NM_133459.3(CCBEl):c.520T> 14737 ['CATCCGGGAAGATGATGGGAAGACAYGTAC

715 C (p.Cysl74Arg) 2 CCBE1 CAGGGGAGACAAATATCCCAA']

NM_000035.3(ALDOB):c.442T> ['GAAAGATGGTGTTGACTTTGGGAAGYGGCG

716 C (p.Trpl48Arg) 229 ALDOB TGCTGTGCTGAGGATTGCCGA']

NM_000320.2(QDPR):c.l06T>C ['AACCAAAGCTGTTTTCTCCTTCCAGYGGGTT

717 (p.Trp36Arg) 5860 QDPR GCCAGCGTTGATGTGGTGGA']

NM_173560.3(RFX6):c.380+2T 22254 ['GCAGACACAGCTCACGCTGCAGTGGYGAGA

718 >C 6 RFX6 CTCGCCCGCAGGGTACACTGA']

NM_173560.3(RFX6):c.649T>C 22254 ['AAAATGTACTAATTTTTTAAGGTTTYCTGGA

719 (p.Ser217Pro) 6 RFX6 AGCAAGCTAAAGAATGAGGT']

NM_000037.3(ANKl):c- ['CTGCGGGGCCTGTGACGTGCGGGCCRGGCC

720 108T>C 286 ANK1 CCCGAGGGCCTTATCGGCCCC]

NM_001145308.4(LRTOMT):c.3 22007 ['TCACATCCTCACCACCCTGGACCACYGGAGC

721 13T>C (p.Trpl05Arg) 4 LRTOMT AGCCGCTGCGAGTACTTGAG]

NM_001012515.2(FECH):c.l268 ['CCTGTCTGCAGGGAGACTAAATCCTYCTTCA

722 T>C (p.Phe423Ser) 2235 FECH CCAGCCAGCAGCTGTGACCC]

NM_000140.3(FECH):c.315- ['TATTGAGTAGAAAACATTTCTCAGGYTGCTA

723 48T>C 2235 FECH AGCTGGAATAAAATCCACTT']

NM_024120.4(NDUFAF5):c.686 ['GCTGTCAATGACCTGGGACATCTGCYTGGG

724 T>C (p.Leu229Pro) 79133 NDUFAF5 AGAGCTGGCTTTAATACTCTG]

NM_000277.1(PAH):c.932T>C ['TTACAGGAAATTGGCCTTGCCTCTCYGGGTG

725 (p.Leu311Pro) 5053 PAH CACCTGATGAATACATTGAA']

NM_000277.1 (PAH) : c.764T>C ['GGCCTGCTTTCCTCTCGGGATTTCTYGGGTG

726 (p.Leu255Ser) 5053 PAH GCCTGGCCTTCCGAGTCTTC]

NM_000277.1 (PAH) : c.143 T>C ['TCACTCAAAGAAGAAGTTGGTGCATYGGCC

727 (p.Leu48Ser) 5053 PAH AAAGTATTGCGCTTATTTGAG]

NM_000277. l(PAH):c.1045T>C ['AAAGGCATATGGTGCTGGGCTCCTGBCATCC

728 (p.Ser349Pro) 5053 PAH TTTGGTGAATTACAGGTATG]

NM_000277.1 (P AH) : c.293 T>C ['GCTCTGACAAACATCATCAAGATCTYGAGG

729 (p.Leu98Ser) 5053 PAH CATGACATTGGTGCCACTGTC]

NM_000277.1(PAH):c.734T>C ['TGCACTGGTTTCCGCCTCCGACCTGHGGCTG

730 (p.Val245Ala) 5053 PAH GCCTGCTTTCCTCTCGGGAT']

NM_000277.1 (PAH) : c.194T>C ['GAGAATGATGTAAACCTGACCCACANTGAA

731 (p.Ile65Thr) 5053 PAH TCTAGACCTTCTCGTTTAAAG]

732 NM_000130.4(F5):c.l l60T>C 2153 F5 ['CATTTGGATAATTTCTCAAACCAAAYTGGAA (p.Ile387Thr) AAC ATT AT A AG A A AGTT AT G]

NM_000512.4(GALNS):c.413T> ['AAGGCCGGCTACGTCAGCAAGATTGYCGGC

733 C (p.Vall38Ala) 2588 GALNS AAGTGGTAAGTCTCCTGGCCA]

NM_018077.2(RBM28):c. l052T ['TCCTTTGACTCAGAAGAAGAAGAACYTGGG

734 >C (p.Leu351Pro) 55131 RBM28 GAGCTTCTCCAACAGTTTGGA']

NM_203395.2(IYD):c.347T>C 38943 ['AATGAGCAAGTCCCAATGGAAGTCAYTGAT

735 (p.Ilell6Thr) 4 IYD AATGTCATCAGAACGGCAGGT']

NM_015702.2(MMADHC):c.776 ['CATTTAGGATTCTCTGTTGATGACCYTGGAT

736 T>C (p.Leu259Pro) 27249 MMADHC GCTGTAAAGTGATTCGTCAT']

NM_014165.3 (NDUF AF4) : c.194 ['AAAGATGAAAAGCTGCTGTCGTTTCYAAAA

737 T>C (p.Leu65Pro) 29078 NDUFAF4 GATGTGTATGTTGATTCCAAA']

NM_001136271.2(NKX2- 13781 ['GCAGGTGCTGGCCCTGGAGCGGCGCYTCAA

738 6):c.451T>C (p.Phel51Leu) 4 NKX2-6 GCAGCAGCGGTACCTGTCAGC]

NM_013319.2(UBIADl):c.511T ['TATCTACTTTGGAGGCCTGTCTGGCYCCTTT

739 >C (p.Serl71Pro) 29914 UBIAD1 CTCTACACAGGAGGTAAGAT']

NM_001127628.1(FBPl):c.581T ['TTGTCTAAAAAGGCCATCGGGGAGTYCATTT

740 >C (p.Phel94Ser) 2203 FBP1 TGGTGGACAAGGATGTGAAG]

NM_000046.3(ARSB):c.349T>C ['TTTACAGCACCAAATAATCTGGCCCYGTCAG

741 (p.Cysl l7Arg) 411 ARSB CCCAGCTGTGTTCCTCTGGA']

NM_000046.3 (ARSB) : c.707T>C ['TCTTTCCAGCCTCTGTTTCTCTACCYTGCTCT

742 (p.Leu236Pro) 411 ARSB CCAGTCTGTGCATGAGCCC]

M_000404.2(GLBl):c.l52T>C ['AAGGATGGCCAGCCATTTCGCTACAYCTCA

743 (p.Ile51Thr) 2720 GLB1 GGAAGCATTCACTACTCCCGT']

M_000404.2(GLBl):c.247T>C ['AAGGGGCTGTGTGTGTCTTGGCAGGBATGTG

744 (p.Tyr83His) 2720 GLB1 CCCTGGAACTTTCATGAGCC]

NM_024782.2(NHEJl):c.367T> ['CCTCCCCTTCTATTGGAATTTCCACYGCATG

745 C (p.Cysl23Arg) 79840 NHEJ1 CTAGCTAGTCCTTCCCTGGT']

NM_139241.3(FGD4):c.893T>C 12151 ['CAGAAATTGGCACCATTCCTTAAGABGTATG

746 (p.Met298Thr) 2 FGD4 GAGAATATGTGAAAGGATTT']

NM_020631.4(PLEKHG5):c.l 94 ['TTGGGCCTTCCCTAACCAGGGTCCTYCCTCC

747 0T>C (p.Phe647Ser) 57449 PLEKHG5 TTATCTACCTGAATGAGTTT']

NM_015559.2(SETBPl):c.2612T ['GAGACGATCCCCAGCGACAGCGGCAYTGGG

748 >C (p.Ile871Thr) 26040 SETBP1 ACAGACAACAACAGCACTTCT']

NM_138387.3(G6PC3):c.554T> ['CTCCTAGGCGCTGTCCTGGGCTGGCYGATGA

749 C (p.Leul85Pro) 92579 G6PC3 CTCCCCGAGTGCCTATGGAG']

NM_022489.3 (INF2) :c .556T>C ['CTTCAGCATTGTCATGAACGAGCTCYCCGGC

750 (p.Serl86Pro) 64423 INF2 AGCGACAACGTGCCCTACGT']

NM_022489.3(INF2):c.l25T>C ['GACCCCGAGCTGTGCATCCGGCTGCYCCAG

751 (p.Leu42Pro) 64423 INF2 ATGCCCTCTGTGGTCAACTAC]

NM_018122.4(DARS2):c.492+2 ['TTTGAAATTAAGAACTTCGTGAAGGBACCA

752 T>C 55157 DARS2 ACCTCTGTTATTAATAAAATA']

NM_015272.3(RPGRIPlL):c. l97 ['CCTTCATCCCGAATATAACTTCACTYCTCAA

753 5T>C (p.Ser659Pro) 23322 RPGRIP1L TATCTTGTTCATGTTAATGA]

754 NM_001029871.3(RSPO4):c.319 34363 RSP04 ['CTTCAGCCAGGACTTCTGCATCCGGYGCAAG T>C (p.Cysl07Arg) 7 AGGCAGTTTTACTTGTACAA']

NM_000429.2(MATlA):c.914T> ['GCTGCCCGCTGGGTGGCCAAGTCTCYGGTG

755 C (p.Leu305Pro) 4143 MAT1A AAAGCAGGGCTCTGCCGGAGA']

NM_032581.3(FAM126A):c.l58 ['AACATTTTGTCTTTCTTCTAGTTGCBAGAAC

756 T>C (p.Leu53Pro) 84668 FAM126A CTGTCTGTCACCAGCTCTTT']

NM_006364.2(SEC23 A):c.1144 ['GGGTGATTCTTTCAATACTTCCTTAYTCAAA

757 T>C (p.Phe382Leu) 10484 SEC23A CAAACTTTTCAAAGAGTCTT']

NM_018006.4(TRMU):c.229T> ['CCATCAAGTGTCCTACGTAAAGGAGYATTG

758 C (p.Tyr77His) 55687 TRMU GAATGATGTGTTCAGGTGAGT']

NM_001174089.1(SLC4Al l):c.2 ['CTGCAGGTGCTTCAGCTGCTGCTGCYGTGTG

759 480T>C (p.Leu827Pro) 83959 SLC4A11 CCTTCGGCATGAGCTCCCTG]

NM_001174089.1(SLC4Al l):c.5 ['AGTGACAGGGGTGCGGTACCAGCAGYCGTG

760 89T>C (p.Serl97Pro) 83959 SLC4A11 GCTCTGCATCATGTGAGTTGC]

NM_148960.2(CLDN19):c.269T 14946 ['GCCCTGATGGTGGTGGCCGTGCTCCYGGGCT

761 >C (p.Leu90Pro) 1 CLDN19 TCGTGGCCATGGTCCTCAGC]

NM_153704.5(TMEM67):c.2498 ['AACACAGATGGTCAGACTTTTGAGAYTGCA

762 T>C (p.Ile833Thr) 91147 TMEM67 ATTTCTAACCAGATGAGACAA']

NM_153704.5(TMEM67):c. l769 ['ACAGGTCTTTACTGGCTTATTTTCTYCAAAG

763 T>C (p.Phe590Ser) 91147 TMEM67 TGAGTGAGTTTCTGAATTTT']

NM_153704.5(TMEM67):c. l843 ['AGAACGTTTTGTCACTTATGTTGGAHGTGCC

764 T>C (p.Cys615Arg) 91147 TMEM67 TTTGCTCTGAAGGTAAGTTT']

NM_153704.5(TMEM67):c.755T ['ACATCTTGTCAAGCTCTTGGAAATAYGTGTG

765 >C (p.Met252Thr) 91147 TMEM67 TGATGAACATGAATTCTTAC]

NM_017777.3(MKSl):c.80+2T> ['CCCCGTGCGCAACTTGCGCCTCCGGYAGTCG

766 C 54903 MKS1 CACCGCCCCAGCCCCGAGGC]

NM_001041.3 (SI) :c .1022T>C ['AATTACATGCTCATTTACTTTAAGCYTGTTG

767 (p.Leu341Pro) 6476 SI GACTACCAGCAATGCCAGCA']

NM_001041.3(SI):c.l859T>C ['ATGGAATGGTCTATAACTGGAATGCYGGAG

768 (p.Leu620Pro) 6476 SI TTCAGTTTGTTTGGAATACCT']

NM_015506.2(MMACHC):c.347 ['CACCCCAACCGACGCCCCAAGATCCYGGCC

769 T>C (p.Leul l6Pro) 25974 MMACHC CAGACAGCAGCCCATGTAGCT']

NM_000190.3 (HMB S) :c.739T> ['GCACGATCCCGAGACTCTGCTTCGCYGCATC

770 C (p.Cys247Arg) 3145 HMBS GCTGAAAGGGCCTTCCTGAG]

NM_000190.3 (HMB S) :c .242T> ['GAGAAAAGCCTGTTTACCAAGGAGCYTGAA

771 C (p.Leu81Pro) 3145 HMBS CATGCCCTGGAGAAGAATGAG]

NM_000237.2(LPL):c.662T>C ['ACCAGAGGGTCCCCTGGTCGAAGCAYTGGA

772 (p.Ile221Thr) 4023 LPL ATCCAGAAACCAGTTGGGCAT']

NM_000237.2(LPL):c.337T>C ['AGACTCCAATGTCATTGTGGTGGACYGGCTG

773 (p.Trpl l3Arg) 4023 LPL TCACGGGCTCAGGAGCATTA']

NM_000237.2(LPL):c.755T>C ['AACATTGGAGAAGCTATCCGCGTGAYTGCA

774 (p.Ile252Thr) 4023 LPL GAGAGAGGACTTGGAGGTAAA]

NM_000263.3 (NAGLU) :c .142T ['GCTGGGGCCAGGCCCCGCGGCCGACYTCTC

775 >C (p.Phe48Leu) 4669 NAGLU CGTGTCGGTGGAGCGCGCTCT']

776 NM_000018.3 (AC AD VL) :c .137 37 ACADVL ['GCGTGTGCTCCGAGATCTTCGCATCYTCCGG 2T>C (p.Phe458Leu) ATCTTTGAGGGGACAAATGA]

NM_018105.2(THAPl):c.241T> ['GAAAGAGAATGCTGTGCCCACAATAYTTCTT

111 C (p.Phe81Leu) 55145 THAPl TGTACTGAGCCACATGACAA]

NM_005908.3(MANBA):c. l513 ['AGACAAGAGTCGTCCTTTTATTACGYCCAGT

11% T>C (p.Ser505Pro) 4126 MANBA CCTACAAATGGGGCTGAAAC]

NM_000124.3(ERCC6):c.2960T ['AAGCAGTTTTTGACAAATAGAGTGCYAAAA

119 >C (p.Leu987Pro) 2074 ERCC6 GACCCAAAACAAAGGCGGTTT']

NM_014845.5 (FIG4) : c.122T>C ['GAAACGAAATATCGTGTCTTGAAGAYTGAT

780 (p.Ile41Thr) 9896 FIG4 AGAACAGAACCAAAAGATTTG]

NM_000787.3 (DBH) :c .339+2T> ['GATGGGGACACTGCCTATTTTGCGGYGAGTC

781 C 1621 DBH TCTCCTCCCTGCCAGCTCTC]

NM_000102.3(CYP17Al):c.316 ['TCTAAAGGCAACTCTAGACATCGCGYCCAA

782 T>C (p.Serl06Pro) 1586 CYP17A1 CAACCGTAAGGGTATCGCCTT']

NM_000102.3(CYP17Al):c.l21 ['GGCGCTGCATCACAATGAGAAGGAGYGGCA

783 6T>C (p.Trp406Arg) 1586 CYP17A1 CCAGCCGGATCAGTTCATGCC]

NM_000102.3(CYP17Al):c.l35 ['GAGATCCTGGCCCGCCAGGAGCTCTYCCTCA

784 8T>C (p.Phe453Ser) 1586 CYP17A1 TCATGGCCTGGCTGCTGCAG']

NM_152783.4(D2HGDH):c.l331 72829 ['GGAGATGGTAACCTGCACCTCAATGYGACG

785 T>C (p.Val444Ala) 4 D2HGDH GCGGAGGCCTTCAGCCCCTCG]

NM_000255.3(MUT):c.313T>C ['TCCTACCATGTATACCTTTAGGCCCYGGACC

786 (p.Trpl05Arg) 4594 MUT ATCCGCCAGTATGCTGGTTT']

NM_000411.6(HLCS):c.710T>C ['CTGTACCAGAAGTTCATGGCCTATCYTTCTC

787 (p.Leu237Pro) 3141 HLCS AGGGAGGGAAGGTGTTGGGC]

NM_022132.4(MCCC2):c.499T> ['AATTGCCATGCAAAACAGGCTCCCCYGCAT

788 C (p.Cysl67Arg) 64087 MCCC2 CTACTTAGGCAAGTCACCAGA']

NM_020166.4(MCCCl):c.l310T ['CATTATGACCCCATGATTGCGAAGCYGGTCG

789 >C (p.Leu437Pro) 56922 MCCC1 TGTGGGCAGCAGATCGCCAG]

NM_198578.3(LRRK2):c.6059T 12089 ['ATTGCAAAGATTGCTGACTACGGCAYTGCTC

790 >C (p.Ile2020Thr) 2 LRRK2 AGTACTGCTGTAGAATGGGG]

NM_000022.2(ADA):c.320T>C ['GAGGTGCGGTACAGTCCGCACCTGCYGGCC

791 (p.Leul07Pro) 100 ADA AACTCCAAAGTGGAGCCAATC]

NM_199242.2(UNC13D):c. l208 20129 ['CTGGCCGCCTCATTCAGCTCCCTGCYGACCT

792 T>C (p.Leu403Pro) 4 UNC13D ACGGCCTCTCCCTCATCCGG]

NM_152443.2(RDH12):c.523T> 14522 ['CCCTGCACGGGTGGTTAATGTGTCCYCGGTG

793 C (p.Serl75Pro) 6 RDH12 GCTCACCACATTGGCAAGAT']

NM_020435.3(GJC2):c.857T>C ['TGCCTGCTGCTCAACCTCTGTGAGAYGGCCC

794 (p.Met286Thr) 57165 GJC2 ACCTGGGCTTGGGCAGCGCG]

NM_000159.3(GCDH):c.883T> ['CTTCGGCTGCCTGAACAACGCCCGGYACGG

795 C (p.Tyr295His) 2639 GCDH CATCGCGTGGGGCGTGCTTGG]

NM_000920.3(PC):c.434T>C ['CGGTTTATTGGGCCAAGCCCAGAAGBGGTC

796 (p.Vall45Ala) 5091 PC CGCAAGATGGGAGACAAGGTG]

NM_207118.2(GTF2H5):c.62T> 40467 ['GATCCTGCCATGAAGCAGTTTCTGCYGTACT

797 C (p.Leu21Pro) 2 GTF2H5 TGGATGAGTCCAATGCCCTG]

798 NM_005787.5(ALG3):c.211T>C 10195 ALG3 ['TCTTCTTCCAGACACAGAGATTGACYGGAA (p.Trp71Arg) GGCCTACATGGCCGAGGTAGA]

NM_024514.4(CYP2Rl):c.296T 12022 ['GGCTATGATGTAGTAAAGGAATGCCYTGTTC

799 >C (p.Leu99Pro) 7 CYP2R1 ATCAAAGCGAAATTTTTGCA]

NM_017929.5(PEX26):c.2T>C ['CTGGGCCTTGGACCCGGACTCGTTAYGAAG

800 (p.MetlThr) 55670 PEX26 AGCGATTCTTCGACCTCTGCA]

NM_017929.5 (PEX26) :c .134T> ['CTTCTGGAGGAGGCGGCCGACCTCCYGGTG

801 C (p.Leu45Pro) 55670 PEX26 GTGCACCTGGACTTCCGGGCG]

NM_213599.2(ANO5):c. l066T> 20385 ['TGGTCAGATGATCATGTGCCCACTCBGTGAT

802 C (p.Cys356Arg) 9 AN05 CAAGTGTGTGATTATTGGAG']

NM_022370.3(ROBO3):c.2113T ['CCAGCTGGTGCAAGGTTTCCGGGTGHCTTGG

803 >C (p.Ser705Pro) 64221 ROB03 AGGGTAGCAGGCCCTGAGGG]

NM_022370.3(ROBO3):c. l4T>C ['CTGGGTCGAGCCATGCTGCGCTACCYGCTGA

804 (p.Leu5Pro) 64221 ROB03 AAACGCTGCTGCAGATGAAC]

NM_207352.3 (CYP4V2) : c.332T 28544 ['GTATGTTTTTCTCTTCCTAAGGTAABTTTAAC

805 >C (p.Ilel l lThr) 0 CYP4V2 TAGTTCAAAGCAAATTGAC]

NM_178857.5(RPlLl):c.2878T> ['GTCTCCAGAGGCTGTGGTCCGCGAAYGGCT

806 C (p.Trp960Arg) 94137 RP1L1 GGACAACATTCCAGAAGAGCC]

NM_018668.4(VPS33B):c.89T> ['GCTCGAGACCAGCTCATCTATCTGCYGGAGC

807 C (p.Leu30Pro) 26276 VPS33B AGGTCAGTGCTTGCCTGACG]

NM_024006.5 (VKORC 1 ) : c.134T ['CGGGATTACCGCGCGCTCTGCGACGYGGGC

808 >C (p.Val45Ala) 79001 VKORC 1 ACCGCCATCAGCTGTTCGCGC]

NM_000551.3(VHL):c.334T>C ['TGGCACGGGCCGCCGCATCCACAGCHACCG

809 (p.Tyrl l2His) 7428 VHL AGGT AC GGGCCC GGC GCTT AG]

NM_000551.3(VHL):c.292T>C ['CAACTTCGACGGCGAGCCGCAGCCCYACCC

810 (p.Tyr98His) 7428 VHL AACGCTGCCGCCTGGCACGGG]

NM_000551.3 (VHL) : c.188T>C ['GAGGCCGGGCGGCCGCGGCCCGTGCYGCGC

811 (p.Leu63Pro) 7428 VHL TCGGTGAACTCGCGCGAGCCC]

NM_000551.3(VHL):c.488T>C ['GTGTATACTCTGAAAGAGCGATGCCYCCAG

812 (p.Leul63Pro) 7428 VHL GTTGTCCGGAGCCTAGTCAAG]

M_014874.3(MFN2):c.227T>C ['CCCGTTACCACAGAAGAACAGGTTCBGGAC

813 (p.Leu76Pro) 9927 MFN2 GTCAAAGGTTACCTATCCAAA']

NM_015046.5 (SETX) : c.1166T> ['AACATGTATGAAGAAATGGAAACATYAGCC

814 C (p.Leu389Ser) 23064 SETX AGTGTACTTCAGTCAGATATT']

NM_005609.2(PYGM):c.1187T> ['TGGCCGGTGCACCTCTTGGAGACGCYGCTGC

815 C (p.Leu396Pro) 5837 PYGM CGCGGCACCTCCAGATCATC]

NM_005609.2(PYGM):c.2392T> ['CTTTGACCTGCAGAACCCAAGAGAGHGGAC

816 C (p.Trp798Arg) 5837 PYGM GCGGATGGTGATCCGGAACAT']

NM_213653.3(HFE2):c.842T>C 14873 ['CATGTGGAGATCCAAGCTGCCTACAYTGGC

817 (p.Ile281Thr) 8 HFE2 ACAACTATAATCATTCGGCAG]

NM_213653.3(HFE2):c.238T>C 14873 ['TGGAGGGGTGGGCTCTGGCGGCCTCBGTCG

818 (p.Cys80Arg) 8 HFE2 AGCCCTCCGCTCCTATGCGCT']

NM_213653.3(HFE2):c.302T>C 14873 ['ACCGCCCGCACCTGCCGCGGGGACCYCGCC

819 (p.LeulOlPro) 8 HFE2 TTCCATTCGGCGGTACATGGC]

820 NM_000045.3 (ARG1 ) :c .32T>C 383 ARGl ['GCCAAGTCCAGAACCATAGGGATTAYTGGA (p.IlellThr) GCTCCTTTCTCAAAGGGACAG]

NM_032409.2(PINKl):c.l040T> ['GCCGCCATGATGCTGCTGCAGCTGCYGGAA

821 C (p.Leu347Pro) -1 - GGCGTGGACCATCTGGTTCAA]

NM_153006.2(NAGS):c.l289T> ['GCCAGGTACAACGCCGCCGCCATTCYGACC

822 C (p.Leu430Pro) -1 - ATGGAGCCCGTCCTGGGGGGC]

NM_153006.2(NAGS):c.l450T> ['CCGGGTCACCAACCCCATCAATCCCBGGTAG

823 C (p.Trp484Arg) -1 - GTCCTGCCACTCCCAGCTCT']

NM_001173464.1(KIF21A):c.30 ['AGTATTTCTGATTGTCAGGCCAACAYAATGC

824 29T>C (p.IlelOlOThr) 55605 KIF21A AGATGGAAGAAGCAAAGGTT']

NM_001173464.1(KIF21A):c. l0 ['GTCAGCCCTTCAGACAGAGACTTTAYGGAA

825 67T>C (p.Met356Thr) 55605 KIF21A ACGTTAAACACCCTGAAATAC]

M_000434.3(NEUl):c. l088T> ['TCATGGCGGAAAGAGACAGTCCAGCYATGG

826 C (p.Leu363Pro) 4758 NEU1 CCAGGCCCCAGTGGCTATTCA]

M_000434.3(NEUl):c.718T>C ['CCTCAGCGATGATCATGGTGCCTCCYGGCGC

827 (p.Trp240Arg) 4758 NEU1 TACGGAAGTGGGGTCAGCGG]

NM_000026.2(AD SL) :c .1312T> ['TGATGCCTACTTCAGTCCCATTCACYCCCAG

828 C (p.Ser438Pro) 158 ADSL TTGGATCATTTACTGGATCC]

NM_000026.2(ADSL):c.674T>C ['TCCAAGGTAGAGCAGCTTGACAAGAYGGTG

829 (p.Met225Thr) 158 ADSL ACAGAAAAGGCAGGATTTAAG]

NM_018400.3(SCN3B):c.29T>C ['CCTGCCTTCAATAGATTGTTTCCCCYGGCTT

830 (p.LeulOPro) 55800 SCN3B CTCTCGTGCTTATCTACTGG]

NM_024577.3(SH3TC2):c.505T ['CCTTCCTGTATCAGGAGTCCCAGGTRTATTG

831 >C (p.Tyrl69His) 79628 SH3TC2 TTTCCAGGTGTTTATCATCT']

NM_000243.2(MEFV):c.2177T> ['GTGGGCATCTTCGTGGACTACAGAGHTGGA

832 C (p.Val726Ala) 4210 MEFV AGCATCTCCTTTTACAATGTG]

NM_000483.4(APOC2):c. l42T> ['GGTGAAGGAATCTCTCTCCAGTTACYGGGA

833 C (p.Trp48Arg) -1 - GTCAGCAAAGACAGCCGCCCA']

NM_058172.5 (ANTXR2) : c.566T 11842 ['CTCTTCTTTCTAAAGCTTGAAAGAAYTGCTG

834 >C (p.Ilel89Thr) 9 ANTXR2 ATTCCAAGGAGCAAGTTTTC]

NM_001128085.1(ASPA):c.454 ['TCAGACTTCTCTGGCTCCACTACCCYGCTAC

835 T>C (p.Cysl52Arg) -1 - GTTTATCTGATTGAGCATCC]

NM_022464.4(SILl):c.645+2T> ['TGACTTATGGACGAAGAAATACAGTRCCTG

836 C 64374 SIL1 ATGGACATAATATTCAAGATC]

NM_001037633.1(SILl):c.l370T ['CTGCTGGGCTCTGTCAACAGCTTGCYGAAGG

837 >C (p.Leu457Pro) 64374 SIL1 AGCTGAGATGAGGCCCCACA']

NM_000391.3(TPPl):c.l093T>C ['TCTCTCAGGTGACAGTGGGGCCGGGYGTTG

838 (p.Cys365Arg) 1200 TPP1 GTCTGTCTCTGGAAGACACCA']

NM_182760.3(SUMFl):c. l006T 28536 ['AGTGAAGAAAGGTGGATCCTACATGYGCCA

839 >C (p.Cys336Arg) 2 SUMF1 TAGGGTAAGTCATGTCACTAA']

NM_182760.3(SUMFl):c.463T> 28536 [' CTT AT AGGCTG AG A AGTTT GGC G AC YCCTTT

840 C (p.Serl55Pro) 2 SUMF1 GTCTTTGAAGGCATGTTGAG']

NM_177986.3(DSG4):c.574T>C ['TGCAGATGAAGAAAATCATCTGAATHCTAA

841 (p.Serl92Pro) -1 - AATTGCCTACAAGATCGTCTC]

842 NM_004183.3(BESTl):c.253T> 7439 BEST1 ['CCCCCGCCCCTCCTGCCCAGGCTTCYACGTG C (p.Tyr85His) ACGCTGGTCGTGACCCGCTG]

NM_004183.3(BESTl):c.l22T> ['TATGGCGAGTTCTTAATCTTCCTGCYCTGCT

843 C (p.Leu41Pro) 7439 BEST1 ACTACATCATCCGCTTTATT']

NM_004183.3(BESTl):c.614T> ['CTTGGAGGTCGAATCCGGGACCCTAYCCTGC

844 C (p.Ile205Thr) 7439 BEST1 TCCAGAGCCTGCTGAACGTG]

NM_004183.3 (BEST1) :c.704T> ['TACGACTGGATTAGTATCCCACTGGYGTATA

845 C (p.Val235Ala) 7439 BEST1 CACAGGTGAGGACTAGGCTG]

NM_024312.4(GNPTAB):c.1120 ['TGTTTGTTGTTGTTAAAAGGATGTTYTTCGA

846 T>C (p.Phe374Leu) 79158 GNPTAB AATTTGAGCCACTTGCCTAC]

NM_000158.3(GBEl):c.671T>C ['TATAAACATTTTACATGCAATGTACYACCAA

847 (p.Leu224Pro) 2632 GBE1 GAATCAAAGGCCTTGGTAAG]

NM_017890.4(VPS13B):c.8459T 15768 ['CAGGTGCCATCTTCAAACAGTTCCAYTATTT

848 >C (p.Ile2820Thr) 0 VPS13B ATGTCTGGTGCACAGTTTTG]

NM_000019.3(ACATl):c.935T> ['CTCAATGTTACACCACTGGCAAGAAYAGTA

849 C (p.Ile312Thr) 38 ACAT1 GGTAAGGCCAGGCGAGGTGGC]

NM_020184.3 (CNNM4) :c .971 T ['CTCAGTTTTCCCATTAGCAAGCTCCYGGACT

850 >C (p.Leu324Pro) 26504 CNNM4 TTTTTCTGGGCCAGGAGATT']

NM_001171507.2(MCFD2):c.40 ['GATGACAAGAACAATGATGGATACAYTGAC

851 7T>C (p.Ilel36Thr) 90411 MCFD2 TATGCTGAATTTGCAAAATCA']

NM_174936.3(PCSK9):c.646T> 25573 ['TGTGCCCGAGGAGGACGGGACCCGCYTCCA

852 C (p.Phe216Leu) 8 PCSK9 CAGACAGGTAAGCACGGCCGT']

NM_000419.3(ITGA2B):c. l787 ['GACTTCCGGGACAAGCTGAGCCCCAYTGTG

853 T>C (p.Ile596Thr) 3674 ITGA2B CTCAGCCTCAATGTGTCCCTA']

NM_000419.3 (ITGA2B) : c.641 T ['CCCTTCCAGGCCGGAGAGCTGGTGCYTGGG

854 >C (p.Leu214Pro) 3674 ITGA2B GCTCCTGGCGGCTATTATTTC]

NM_004817.3(TJP2):c.l43T>C ['TCCAAAAGAGGATTTGGAATTGCAGYGTCC

855 (p.Val48Ala) 9414 TJP2 GGAGGCAGAGACAACCCCCAC]

NM_173477.4(USHlG):c.l43T> 12459 ['GCCTACCATGGCAACCTCGAGTCGCYGCGTC

856 C (p.Leu48Pro) 0 USH1G TCATTGTGAGCCGCGGGTGA']

NM_000271.4(NPCl):c.3182T> ['GACGCTCTGAAGAAAGCCCGACTTAYAGCC

857 C (p.Ilel061Thr) 4864 NPC1 AGTAATGTCACCGAAACCATG]

NM_000271.4(NPCl):c.l l33T> ['TTTGTCCGGGTCACAACCAATCCAGYTGACC

858 C (p.Val378Ala) 4864 NPC1 TCTGGTCAGCCCCCAGCAGC]

NM_000271.4(NPCl):c.337T>C ['ACTGAACCTGTTTTGTGAGCTGACAYGTAGC

859 (p.Cysl l3Arg) 4864 NPC1 CCTCGACAGAGTCAGTTTTT']

NM_000543.4(SMPDl):c.911T> ['CGGGCCCTGACCACCGTCACAGCACYTGTG

860 C (p.Leu304Pro) 6609 SMPD1 AGGAAGTTCCTGGGGCCAGTG]

NM_000226.3(KRT9):c.503T>C ['CTCAATTCTCGGCTGGCCTCTTACTYGGATA

861 (p.Leul68Ser) 3857 KRT9 AGGTGCAGGCTCTAGAGGAG]

NM_000226.3(KRT9):c.470T>C ['CTGACTGCTAATGAGAAGAGCACCANGCAG

862 (p.Metl57Thr) 3857 KRT9 GAACTCAATTCTCGGCTGGCC]

NM_000051.3(ATM):c.7967T>C ['CCAGCAGACCAGCCAATTACTAAACYTAAG

863 (p.Leu2656Pro) -1 - AATTTAGAAGATGTTGTTGTC]

864 NM_000487.5(ARSA):c.410T>C 410 ARSA ['GGGGTGGGGCCTGAGGGGGCCTTCCYGCCC (p.Leul37Pro) CCCCATCAGGGCTTCCATCGA']

NM_017653.3(DYM):c.l624T> ['AATGATGTTAGAGATCATCAACTCCYGCCTG

865 C (p.Cys542Arg) 54808 DYM ACAAATTCCCTTCACCACAA']

NM_016038.2(SBDS):c.258+2T ['GACCAAACTGAAATCTGTAAGCAGGYGGGT

866 >C 51119 SBDS AACAGCTGCAGCATAGCTAAC]

NM_001079802.1(FKTN):c.527 ['ACTCATGCGATCCACTTGGTAGTCTYTCATG

867 T>C (p.Phel76Ser) 2218 FKTN AGAGGAGTGGCAACTACCTC]

NM_013382.5 (POMT2) : c.2242T ['GGCAGGACTAAGGTGGCTGGACTCAYGGGA

868 >C (p.Trp748Arg) 29954 POMT2 CTTTTGAGGCCACTGCAAAGA']

NM_024529.4(CDC73):c.l91T> ['ACATTGGATTCCATTTTATTTCTACYTAATA

869 C (p.Leu64Pro) 79577 CDC73 ACGTGCACCTTTCTCATCCT']

NM_000268.3(NF2):c.l079T>C ['ACGAGGGATGAGTTGGAGAGGAGGCYGCTG

870 (p.Leu360Pro) 4771 NF2 CAGATGAAAGAAGAAGCAACA']

NM_000268.3(NF2):c.l604T>C ['GAATACATGGAAAAGAGCAAGCATCYGCAG

871 (p.Leu535Pro) 4771 NF2 GAGCAGCTCAATGAACTCAAG]

NM_000268.3(NF2):c.l85T>C ['CTGGGGCTCCGAGAAACCTGGTTCTYTGGAC

872 (p.Phe62Ser) 4771 NF2 TGCAGTACACAATCAAGGAC]

NM_139248.2(LIPH):c.322T>C 20087 ['AGACATGAACGTAGTTGTTGTTGATYGGAAT

873 (p.Trpl08Arg) 9 LIPH CGAGGAGCTACAACTTTAAT']

NM_015102.4(NPHP4):c.2972T 26173 ['GCCACGCTGGGGGTCGCCGAGTTCTYTGAGT

874 >C (p.Phe991Ser) 4 NPHP4 TTGTGCTTAAGAACCCCCAC]

NM_024105.3(ALG12):c.473T> ['ACCCTCCCGCACTGTCTTGCAGTCCYGCTGG

875 C (p.Leul58Pro) 79087 ALG12 CCCTCGCGGCCTGGCTGCGG]

NM_000280.4(PAX6):c.773T>C ['GTCCCACCTGATTTCCAGGTATGGTYTTCTA

876 (p.Phe258Ser) 5080 PAX6 ATCGAAGGGCCAAATGGAGA']

NM_024426.4(WTl):c. l351T>C ['CTCTGTCCATTTAGGTGTGAAACCAYTCCAG

877 (p.Phe451Leu) 7490 WT1 TGTAAAACTTGTCAGCGAAA']

NM_024426.4(WTl):c. l378T>C ['CCAGTGTAAAACTTGTCAGCGAAAGYTCTCC

878 (p.Phe460Leu) 7490 WT1 CGGTCCGACCACCTGAAGAC]

NM_005957.4(MTHFR):c.968T> ['GTGCCAGGCCTCCACTTCTACACCCYCAACC

879 C (p.Leu323Pro) 4524 MTHFR GCGAGATGGCTACCACAGAG]

NM_016247.3 (IMPG2) :c .370T> ['TCACGCCCAGGAAGTCGATCCCAAARAGTC

880 C (p.Phel24Leu) 50939 IMPG2 CTGAAGGCTTCCCAGACAGCT']

NM_002225.3 (IVD) : c.134T>C ['CCCGTGGACGATGCAATCAATGGGCYAAGC

881 (p.Leu45Pro) 3712 IVD GAGGAGCAGAGGCAGGTGAGG]

NM_001127328.2(ACADM):c.l ['CAGTTAGCTACTGATGCTGTGCAGAYACTTG

882 136T>C (p.Ile379Thr) 34 ACADM GAGGCAATGGATTTAATACA']

NM_001127328.2(ACADM):c.7 ['TTAGGAATTAAACATGGGCCAGCGAYGTTC

883 42T>C (p.Cys248Arg) 34 ACADM AGATACTAGAGGAATTGTCTT']

NM_000016.5(ACADM):c. l99T ['GGAAATCATCCCAGTGGCTGCAGAAYATGA

884 >C (p.Tyr67His) 34 ACADM TAAAACTGGTGAAGTAGGTAT']

NM_000155.3(GALT):c.221T>C ['CCCCGCCATGACCCTCTCAACCCTCBGTGTC

885 (p.Leu74Pro) 2592 GALT CTGGGGCCATCCGAGCCAAC]

886 NM_000155.3 (GALT) :c .512T>C 2592 GALT ['CTCCGTATCCCTATCTGATAGATCTYTGAAA (p.Phel71Ser) ACAAAGGTGCCATGATGGGC]

NM_000155.3 (GALT) :c .580T>C ['CCCTTGACAGGTATGGGCCAGCAGTYTCCTG

887 (p.Phel94Leu) 2592 GALT CCAGATATTGCCCAGCGTGA]

NM_000250.1(MPO):c.752T>C ['ACTCCGGACCAGGAGCGCTCACTCAYGTTC

888 (p.Met251Thr) 4353 MPO ATGCAATGGGGCCAGCTGTTG]

NM_020247.4(ADCK3):c. l398+ ['CTCAGCCAGGAGATTCGGAACGAGGYTTGT

889 2T>C 56997 ADCK3 CTGTGCCAGCAGACAGGTGGG]

NM_000229.1(LCAT):c.508T>C ['GACTGTGCGCGCCGCCCCCTATGACYGGCG

890 (ρ.Τφ170Α¾) 3931 LCAT GCTGGAGCCCGGTGAGTGTCT']

NM_000229.1(LCAT):c.698T>C ['CGCTTTATTGATGGCTTCATCTCTCYTGGGG

891 (p.Leu233Pro) 3931 LCAT CTCCCTGGGGTGGCTCCATC]

NM_000229.1(LCAT):c.524- ['CAGGTGCCCCAGACCCCAGCTGCCCYGACC

892 22T>C 3931 LCAT CCTTCCACCCGCTGCAGGCCA]

NM_000403.3 (GALE) :c.548T>C ['CCACAGACTTGGAACGCAGTGCTGCYGCGC

893 (p.Leul83Pro) 2582 GALE TATTTCAACCCCACAGGTGCC]

NM_000527.4(LDLR):c.694+2T ['ACAAATCTGACGAGGAAAACTGCGGYATGG

894 >C 3949 LDLR GCGGGGCCAGGGTGGGGGCGG]

NM_000375.2(UROS):c.217T>C ['CAGAGCAGTGGAAGCAGCAGAGTTAYGTTT

895 (p.Cys73Arg) 7390 UROS GGAGCAAAACAATAAAACTGA']

NM_000375.2(UROS):c.-26- ['GCTAACATGCTCTTTCTTGGCCTTAYCAGTG

896 177T>C 7390 UROS ACAGGGGTCTTCAGAAAGAA']

NM_000372.4(TYR):c.265T>C ['GCCTTCCGTCTTTTATAATAGGACCYGCCAG

897 (p.Cys89Arg) 7299 TYR TGCTCTGGCAACTTCATGGG']

NM_000017.3(ACADS):c.529T> ['CACCGCCCGGGCCGAGGGCGACTCABGGGT

898 C (ρ.Τφ177Α¾) 35 ACADS TCTGAATGGAACCAAAGCCTG]

NM_000053.3(ATP7B):c.3443T ['GCGCCTCAGCCACTCACGGTTTCCARTCAGC

899 >C (p.Ilel l48Thr) 540 ATP7B ACAGAGAAGGTCTGGGGGAC]

NM_000053.3(ATP7B):c.2123T ['GCCTTCACTGTCCTTGTCTTTCAGCYCCTCG

900 >C (p.Leu708Pro) 540 ATP7B GTGGGTGGTACTTCTACGTT']

NM_000520.4(HEXA):c.1453T> ['AGCAGGGGCTGTTGCCGAAAGGCTGYGGAG

901 C (ρ.Τφ485Α¾) 3073 HEXA CAACAAGTTGACATCTGACCT']

NM_000520.4(HEXA):c.632T>C ['TGGCATCTGGTAGATGATCCTTCCTYCCCAT

902 (p.Phe211Ser) 3073 HEXA ATGAGAGCTTCACTTTTCCA]

NM_000520.4(HEXA):c.538T>C ['CTTGCTGTTGGATACATCTCGCCATYACCTG

903 (p.Tyrl80His) 3073 HEXA CCACTCTCTAGCATCCTGGA']

NM_016335.4(PRODH):c. l322T ['CTGGGCCAGGTATGCGCCCCGCACCRGCTTG

904 >C (p.Leu441Pro) 5625 PRODH GCCCCAAAACACCAGCCCTC]

NM_000152.3(GAA):c.953T>C ['GTGTTCCTGCTAAACAGCAATGCCAYGGGT

905 (p.Met318Thr) 2548 GAA AAGCTGCCCGCCGCCCAGCGC]

NM_012213.2(MLYCD):c. l l9T ['GCGGCCGGCGCCCTGGAGCGGGCCAYGGAC

906 >C (p.Met40Thr) 23417 MLYCD GAGCTGCTGCGCCGCGCGGTG]

NM_012464.4(TLLl):c.713T>C ['AAGAACTGTGATAAATTTGGGATTGYTGTTC

907 (p.Val238Ala) 7092 TLL1 ATGAATTGGGTCATGTGATA']

908 NM_000112.3 (SLC26 A2) : c. - 1836 SLC26A2 ['CCTGCAGCGGCCCGGACCCGAGAGGYGAGA 26+2T>C AGAGGGAAGCGGACCAGGGAA']

NM_138691.2(TMCl):c. l543T> 11753 ['CCCTGCAGATGTACCTCGAGGACCTYGCTGG

909 C (p.Cys515Arg) 1 TMC1 GAAACAATGGTGGGACAGGT']

NM_138694.3(PKHDl):c.10658 ['GTTGTCCTACAAGGAGAGGAGCCCAYTGAA

910 T>C (p.Ile3553Thr) 5314 PKHD1 ATACGCTCAGGTGTTTCCATT']

NM_001034116.1(EIF2B4):c. l3 ['TGCAGATGACCCTGATGATCTGCAAYGTAA

911 93T>C (p.Cys465Arg) 8890 EIF2B4 GCGGGGAGAACATGTTGCGCT']

NM_001034116.1(EIF2B4):c. l4 ['ATCCCTACGGTTGTTGAATCTAGTCYATGAT

912 65T>C (p.Tyr489His) 8890 EIF2B4 GTGACTCCCCCAGAGCTTGT']

NM_018960.4(GNMT):c. l49T> ['ACCGCCGAGTACAAGGCATGGCTGCYTGGG

913 C (p.Leu50Pro) 27232 GNMT CTGCTGCGCCAGCACGGCTGC]

NM_181457.3(PAX3):c.268T>C ['CTGCGTCTCCAAGATCCTGTGCAGGYACCAG

914 (p.Tyr90His) 5077 PAX3 GAGACTGGCTCCATACGTCC]

NM_024301.4(FKRP):c.899T>C ['GAGACCACGCGCTGCTTCGGAACCGYGGTG

915 (p.VaDOOAla) 79147 FKRP GGCGACACGCCCGCCTACCTC]

NM_021020.3(LZTSl):c.85T>C ['TTCGCAGTACAAGCTGCGCAAGTCCYCCCAC

916 (p.Ser29Pro) 11178 LZTS1 CTCAAGAAGCTCAACCGGTA']

NM_005857.4(ZMPSTE24):c.l0 ['TGTACTAGGCCATGAACTGGGGCACYGGAA

917 18T>C (p.Trp340Arg) 10269 ZMPSTE24 GTTGGGACATACAGTCAAAAA']

NM_017838.3(NHP2):c.415T>C ['GCCCCATGAGGAGTACCAGGAGGCTYACGA

918 (p.Tyrl39His) 55651 NHP2 TGAGTGCCTGGAGGAGGTGCA']

NM_000157.3(GBA):c.l448T>C ['GGGATGCATCAGTGCCACTGCGTCCVGGTC

919 (p.Leu483Pro) 2629 GBA GTTCTTCTGACTGGCAACCAG]

NM_001005741.2(GBA):c.751T ['CATCTACCACCAGACCTGGGCCAGAYACTTT

920 >C (p.Tyr251His) 2629 GBA GTGAAGTAAGGGATCAGCAA']

NM_001243133.1(NLRP3):c. l71 11454 ['AAATTCGAAAAGGGGTATTTGATTTYTGTTG

921 8T>C (p.Phe573Ser) 8 NLRP3 TACGTTTCCTCTTTGGCCTG]

NM_001243133.1 (NLRP3 ) : c.926 11454 ['GGCTTCGATGAGCTGCAAGGTGCCTYTGAC

922 T>C (p.Phe309Ser) 8 NLRP3 GAGCACATAGGACCGCTCTGC]

NM_001243133.1(NLRP3):c. l05 11454 ['CTCATCACCACGAGACCTGTGGCCCYGGAG

923 8T>C (p.Leu353Pro) 8 NLRP3 AAACTGCAGCACTTGCTGGAC]

NM_057176.2(BSND):c.35T>C ['GAGAAGACCTTCCGGATCGGCTTCAYTGTGC

924 (p.Ilel2Thr) 7809 BSND TGGGGCTTTTCCTGCTGGCC]

NM_001195794.1(CLRNl):c.48 ['TCTGTTGCAGGCTCCTGTGGCTGTCYTGTCA

925 8T>C (p.Leul63Pro) 7401 CLRN1 TGATATTGTTTGCCTCTGAA']

NM_175073.2(APTX):c.668T>C ['GCTGTGGCCAGGGAACACCTTGAACYCCTT

926 (p.Leu223Pro) 54840 APTX AAGCATATGCACACTGTGGGG]

NM_020365.4(EIF2B3):c. l037T ['CCACCAGTCCATTCGTCAGCCCAGAYTGTCA

927 >C (p.Ile346Thr) 8891 EIF2B3 GCAAACACCTGGTAAGTGCT']

NM_031433.3(MFRP):c.545T>C ['ATCCAGGTGGCCACAGACCATGCAAYACAG

928 (p.Ilel82Thr) -1 - CTCAAGATCGAAGCCCTCAGC]

NM_016180.4(SLC45A2):c. l082 ['AGTGCACACAACTCCACAGAGTTTCYCATCT

929 T>C (p.Leu361Pro) 51151 SLC45A2 ACGAAAGAGGAGTCGAGGTT']

930 NM_006005.3(WFSl):c.2486T> 7466 WFS1 ['AGCCTCATCGAGTTCAGCACCATCCYGGAG C (p.Leu829Pro) GGCCGCCTGGGCAGCAAGTGG]

NM_024960.4(PANK2):c.178T> ['GATCAAAGGAATTTTATACATTGACYCAGTC

931 C (p.Ser60Pro) 80025 PANK2 GGATTCAATGGACGGTCACA]

NM_024960.4(PANK2):c.437T> ['ACCACTTTTGAAGAAGCTCTTGAAAYGGCAT

932 C (p.Metl46Thr) 80025 PANK2 CTCGTGGAGATAGCACCAAA]

NM_020427.2(SLURPl):c.43T> ['TGTGCAGCTGCTGCTCGTGGCAGCCYGGAG

933 C (p.Trpl5Arg) 57152 SLURP 1 CATGGGCTGTGGTGAGTGGGC]

NM_020427.2(SLURPl):c.229T ['GGTGACCCGCTCCTGCTCCAGCTCCYGTGTG

934 >C (p.Cys77Arg) 57152 SLURP 1 GCCACCGACCCCGACAGCAT']

NM_021830.4(C10orf2):c. ll42T ['CTTCGGGAGGAGGTGCTAGGAGAACBGTCA

935 >C (p.Leu381Pro) 56652 ClOorQ AATGTGGAGCAAGCAGCTGGC]

NM_001033855.2(DCLRElC):c. ['CCGGACTCTGGGATCGGCGGCGCTAYGAGT

936 2T>C (p.MetlThr) 64421 DCLRE1C TCTTTCGAGGGGCAGATGGCC]

NM_153741.1(DPM3):c.254T>C ['CAGATACAGGAGGCCCGAGCCGACTYAGCC

937 (p.Leu85Ser) 54344 DPM3 CGCAGGGGGCTGCGCTTCTGA]

M_000441.1 (SLC26 A4) : c.707 ['GCCTTCCAAGTGCTGGTCTCACAGCYAAAG

938 T>C (p.Leu236Pro) 5172 SLC26A4 ATTGTCCTCAATGTTTCAACC]

M_000441.1(SLC26A4):c. l588 ['TGGAAGCATCCCTAGCACAGATATCYACAA

939 T>C (p.Tyr530His) 5172 SLC26A4 AAGTACCAAGAATTACAAAAA']

M_000441.1 (SLC26 A4) : c. - ['CTTTCCCTTCGACCAAGGTGTCTGTYGCTCC

940 103T>C -1 - GTAAATAAAACGTCCCACTG]

NM_000441. l(SLC26A4):c.1003 ['ATTTTTCACTTAAAAACTCACTAGGHTTTTG

941 T>C (p.Phe335Leu) 5172 SLC26A4 CCTCCTGAACTTCCACCTGT']

NM_022458.3(LMBRl):c.423+4 ['AACAAAGATTTTTTTAATATGTTTCYATCCT

942 842T>C 64327 LMBR1 GTGTCACAGTTTGAAATTGT']

NM_022458.3(LMBRl):c.423+4 ['AAAGCTGAGCAACATGACAGCACAAYAGAG

943 808T>C 64327 LMBR1 GAGGAACAAAGATTTTTTTAA']

NM_145693.2(LPINl):c.1441+2 ['GCGACCACCGGGAGATCACGAAAGGYACCG

944 T>C 23175 LPIN1 CGGGCCTCGCGCGGGCGCCCT']

NM_022124.5(CDH23):c.5663T ['AGTGGCTGCAATGCACGCCTCACCTYCAAC

945 >C (p.Phel888Ser) 64072 CDH23 ATCACTGCGGGCAACCGCGAG]

NM_153212.2(GJB4):c.409T>C 12753 ['GTGGACGTACTTGCTGAGCCTCATCYTCAAG

946 (p.Phel37Leu) 4 GJB4 GCCGCCGTGGATGCTGGCTT']

NM_021044.2(DHH):c.2T>C ['TTTTGGCCGAGGTCCGCTGTATCCAYGGCTC

947 (p.MetlThr) 50846 DHH TCCTGACCAATCTACTGCCC]

NM_021044.2(DHH):c.485T>C ['CGCGACCGCAACAAGTATGGGTTGCYGGCG

948 (p.Leul62Pro) 50846 DHH CGCCTCGCAGTGGAAGCCGGC]

NM_020638.2(FGF23):c.287T> ['GTGATGAGCAGAAGATACCTCTGCAYGGAT

949 C (p.Met96Thr) 8074 FGF23 TTCAGAGGCAACATTTTTGGA']

NM_022041.3 (GAN) :c .1268T>C ['TGCTATGCAGCTATGAAAAAGAAAAYCTAC

950 (p.Ile423Thr) 8139 GAN GCCATGGGTGGAGGCTCCTAC]

NM_015665.5(AAAS):c.787T>C ['CAGTGGGGGGCGGCTGCTCTCAGCTYCACC

951 (p.Ser263Pro) 8086 AAAS CGTGGATGCTGCTATCCGGGT']

952 NM_021615.4(CHST6):c.827T> 4166 CHST6 ['TACCGCCTGGTGCGCTTCGAGGACCYGGCG C (p.Leu276Pro) CGGGAGCCGCTGGCAGAAATC]

NM_000368.4(TSCl):c.539T>C ['GTGGCGGAAGTCTATCTCGTCCATCYCCATG

953 (p.Leul80Pro) 7248 TSC1 CCAGTGTGTACGCACTCTTT']

NM_020661.2(AICDA):c.238T> ['CCCTGGCCGCTGCTACCGCGTCACCYGGTTC

954 C (p.Trp80Arg) 57379 AICDA ACCTCCTGGAGCCCCTGCTA']

NM_020661.2(AICD A) : c.317T> ['CTGCGAGGGAACCCCAACCTCAGTCYGAGG

955 C (p.Leul06Pro) 57379 AICDA ATCTTCACCGCGCGCCTCTAC]

NM_020661.2(AICDA):c.452T> ['GATTATTTTTACTGCTGGAATACTTYTGTAG

956 C (p.Phel51Ser) 57379 AICDA AAAACCACGAAAGAACTTTC]

NM_020632.2(ATP6V0A4):c.17 ['ATCATTCTGCAATTTATCCCTGAGAYGATTT

957 39T>C (p.Met580Thr) 50617 ATP6V0A4 TTATCCTGTGTCTGTTTGGA']

NM_054027.4(ANKH):c.143T> ['GCTGTCAAGGAGGATGCAGTCGAGAYGCTG

958 C (p.Met48Thr) 56172 ANKH GCCAGCTACGGGCTGGCGTAC]

NM_054027.4(ANKH):c. l015T> ['TGTTTGATGTCTTTCTCCCCAGCTCYGTTTCG

959 C (p.Cys339Arg) 56172 ANKH TGATGTTTTGGACACCCAA']

NM_054027.4(ANKH):c.1172T> ['GTGAGGGCGCATCTCACCGGGTGGCYGATG

960 C (p.Leu391Pro) -1 - ACACTGAAGAAAACCTTCGTC]

NM_016373.3 (WWOX) : c.872T> ['ACAAAAAACGACTATTGGGCGATGCYGGCT

961 C (p.Leu291Pro) 51741 WWOX TATAACAGGTCCAAGCTCTGC]

NM_021102.3 (SPINT2) : c.337+2 ['CAGCGGATTCCTCTGTCCCAAGTGGYAGGTT

962 T>C 10653 SPINT2 CTTAAAGAGACCCGCGATGG]

NM_014588.5(VSXl):c.50T>C [' G AC GGGC GCACTAGCAGCAGGGC GC YGGTG

963 (p.Leul7Pro) 30813 VSX1 CCTGGCGGTTCCCCTAGGGGC]

NM_006946.2(SPTBN2):c.758T ['GAAAAGGAACTGGGACTTACCAAGCYGCTG

964 >C (p.Leu253Pro) 6712 SPTBN2 GATCCCGAAGGTGGGGCCAGA]

NM_012452.2(TNFRSF13B):c.3 TNFRSF13 ['GCACCCTAAGCAATGTGCATACTTCYGTGAG

965 10T>C (p.Cysl04Arg) 23495 B AACAAGCTCAGGAGCCCAGT']

NM_170784.2(MKKS):c.830T> ['GAAAATGCAGTCTTGGACCAGCTGCYTAAC

966 C (p.Leu277Pro) 8195 MKKS CTAGGAAGGCAGCTAATCAGT']

NM_015717.4(CD207):c.790T> ['AATGGCGTGTCATCCACCCAGGACCRGTCCC

967 C (p.Trp264Arg) 50489 CD207 CTTCCATCCCTGCTTTAGTC]

NM_153717.2(EVC):c.919T>C ['TGTGGAAAAGAAGGAGAGAGAATACYCTGA

968 (p.Ser307Pro) 2121 EVC ACAGCTAATCGATAATGTGCG]

M_014384.2(ACAD8):c.455T> ['AAATTTTGCCCACCGCTCTGTACCAYGGAGA

969 C (p.Metl52Thr) 27034 ACAD8 AGTTTGCTTCCTACTGCCTC]

NM_004924.4(ACTN4):c.784T> ['CGAGAAGGCCATAATGACCTATGTGYCCAG

970 C (p.Ser262Pro) 81 ACTN4 CTTCTACCATGCCTTTTCAGG]

NM_005097.3(LGIl):c. l36T>C ['AGCGAAGCCAAAATGCCCTGCCGTGYGTAC

971 (p.Cys46Arg) 9211 LGI1 TTGTACCAAAGATAATGCTTT']

NM_005097.3(LGIl):c.695T>C ['GCAGAATTTGCAAAGTCTCAAGACCYGCCTT

972 (p.Leu232Pro) 9211 LGI1 ATCAATCATTGTCCATAGAC]

NM_006329.3(FBLN5):c.679T> ['GCAAACCTGCGTCAACACCTACGGCYCTTTC

973 C (p.Ser227Pro) 10516 FBLN5 ATCTGCCGCTGTGACCCAGG']

974 NM_006329.3(FBLN5):c.506T> 10516 FBLN5 ['TTGCTTGCATTTCTGTTTCCAGACAYTGATG C (p.Ilel69Thr) AATGTCGCTATGGTTACTGC]

NM_013339.3(ALG6):c.l432T> ['GTTTTCTGTATTGGTGTGTTTTGTAYCTTGCT

975 C (p.Ser478Pro) 29929 ALG6 TGAACTTCCTGTTCTTCTT']

NM_006899.3(IDH3B):c.395T> ['GAGCTAGCCTCCTATGATATGCGGCYGAGG

976 C (p.Leul32Pro) 3420 IDH3B TAGGTGGTCTGGGTGGGGTGA']

NM_014363.5(SACS):c.5836T> ['AATGGATTATACTTACTATGCAGTAYGGCCC

977 C (p.Trpl946Arg) 26278 SACS GATCCTGATTTAGTTCATGA']

NM_014363.5(SACS):c.9742T> ['AAGTGAGTCTTGGCTTAAGAATGCAYGGCA

978 C (p.Trp3248Arg) 26278 SACS TTTTATTAGTGAATCTGTAAG]

NM_014363.5(SACS):c.3161T> ['CAGATGGTATCAGCTGGTGAACTCTYTGACC

979 C (p.Phel054Ser) 26278 SACS CTGATATAGAAGTACTAAAG]

NM_014324.5(AMACR):c. l54T ['GAGCCGCTTGGGCCGGGGCAAGCGCYCGCT

980 >C (p.Ser52Pro) -1 - AGTGCTGGACCTGAAGCAGCC]

NM_014324.5(AMACR):c.320T ['AATCCAAGGCTTATTTATGCCAGGCYGAGTG

981 >C (p.Leul07Pro) -1 - GATTTGGCCAGTCAGGAAGC]

NM_001040108.1(MLH3):c382 ['GACAGAGGAACAAAGGAGACTCTTAYGGTC

982 6T>C (p.Trpl276Arg) 27030 MLH3 AGTACCACCATGAGAATGTGA']

NM_014336.4(AIPLl):c.715T>C ['TACTCTGATCCTCAACTACTGCCAGYGCCTG

983 (p.Cys239Arg) 23746 AIPL1 CTGAAGAAGGAGGAGTACTA]

NM_001001486.1(ATP2Cl):c.l7 ['CTCTCATTTGCTTTAGCCAGTCGTCYGGGAT

984 51T>C (p.Leu584Pro) 27032 ATP2C1 TGTATTCCAAAACTTCCCAG]

NM_007194.3 (CHEK2) : c.470T> ['GAAGTGGGTCCTAAAAACTCTTACAYTGCAT

985 C (p.Ilel57Thr) 11200 CHEK2 ACATAGAAGATCACAGTGGC]

NM_007255.2(B4GALT7):c.617 ['ACCTATGTCGGCGGCATCCTGCTGCYCTCCA

986 T>C (p.Leu206Pro) 11285 B4GALT7 AGCAGCACTACCGGCTGGTG]

NM_000030.2(AGXT):c.613T>C ['ATCTACAGGCATCGACATCCTGTACYCGGGC

987 (p.Ser205Pro) 189 AGXT TCCCAGAAGGCCCTGAACGC]

NM_000030.2(AGXT):c.731T>C ['AAGCCCTTCTCCTTCTACCTGGACAYCAAGT

988 (p.Ile244Thr) 189 AGXT GGCTGGCCAACTTCTGGGGC]

NM_201253.2(CRBl):c.3122T> ['ACATGGCACGAAGTGACCCTTTCCAYGACA

989 C (p.Metl041Thr) 23418 CRB1 GACCCACTGTCCCAGACCTCC]

NM_201253.2(CRBl):c.3541T> ['ACACTGTGAACTCAACATCGATGAAYGCTTT

990 C (p.Cysl l81Arg) 23418 CRB1 TCAAACCCCTGTATCCATGG']

NM_005094.3(SLC27A4):c.739 ['AGATAAACTGTTCTACATCTACACAYCCGGC

991 T>C (p.Ser247Pro) 10999 SLC27A4 ACCACAGGGCTGCCCAAGGC]

NM_032551.4(KISSlR):c.443T> ['CGCTGGTACGTGACGGTGTTCCCGTYGCGCG

992 C (p.Leul48Ser) 84634 KISS1R CCCTGCACCGCCGCACGCCC]

NM_032551.4(KISSlR):c.305T> ['TGCTGCGTCCCCTTCACGGCCCTGCYGTACC

993 C (p.Leul02Pro) 84634 KISS1R CGCTGCCCGGCTGGGTGCTG]

NM_014270.4(SLC7A9):c.13 IT ['ATCTCCATCATCGTGGGCACCATCAYTGGCT

994 >C (p.Ile44Thr) 11136 SLC7A9 CTGGGATCTTCGTTTCCCCC]

NM_003332.3(TYROBP):c.2T> ['TGGTGTCCAGCAGCATCCGGCTTCAYGGGG

995 C (p.MetlThr) 7305 TYROBP GGACTTGAACCCTGCAGCAGG]

996 NM_000843.3 (GRM6) :c .1214T> -1 - ['CAGGAGGGCAAGGTGCAGTTTGTGAYTGAT C (p.Ile405Thr) GCGGTGTACGCCATTGCCCAC]

NM_022336.3(EDAR):c.259T>C ['GTTTTCCAAAGGAGGCTACCAGATAYGCAG

997 (p.Cys87Arg) 10913 EDAR GCGTCACAAAGACTGTGAGGG]

NM_003835.3(RGS9):c.895T>C ['CCCAACCAAGATGCGAGTGGAACGAYGGGC

998 (p.Tip299Arg) 8787 RGS9 CTTCAACTTCAGCGAATTGAT']

NM_004870.3 (MPDU 1 ) :c .356T> ['CTCCAGACGATCACCATCTGCTTCCYGGTCA

999 C (p.Leul l9Pro) 9526 MPDU1 TGCACTACAGAGGACAGACT']

NM_004870.3(MPDUl):c.2T>C ['ACTGGCGGAAGCTAGCTTTGCAATAYGGCG

1000 (p.MetlThr) 9526 MPDU1 GCCGAGGCGGACGGACCGCTT']

NM_004870.3(MPDUl):c.221T> ['CTGGGAGCCAAGAGTGCTGAAGGGTYGAGT

1001 C (p.Leu74Ser) 9526 MPDU1 CTCCAGTCTGTAATGCTGGAG]

NM_000334.4(SCN4A):c.2078T ['ACGCTGAACATGCTCATCAAGATCAYTGGC

1002 >C (p.Ile693Thr) 6329 SCN4A AATTCAGTGGGGGCGCTGGGT']

NM_006580.3(CLDN16):c.500T ['GCTGGGTTTGGATTTCTCACCCTGCYCCTTG

1003 >C (p.Leul67Pro) 10686 CLDN16 GTCTTGACTGCGTGAAATTC]

NM_006580.3(CLDN16):c.434T ['ATATGCCCTGGTCTTCCAGTGAAGCYGGTGG

1004 >C (p.Leul45Pro) 10686 CLDN16 TAACTCGAGCGTTGATGATT']

NM_003907.2(EIF2B5):c. l882T ['CTTTCTTCCATAGCTGCTAAAGGCCYGGAGC

1005 >C (p.Trp628Arg) 8893 EIF2B5 CCTGTTTTTAGGAACTACAT']

NM_183235.2(RAB27A):c.389T ['TATTGTGAAAACCCAGATATAGTGCYGTGTG

1006 >C (p.Leul30Pro) 5873 RAB27A GAAACAAGAGTGATCTGGAG]

NM_001128227.2(GNE):c.2228 ['CCCGCCCTGCTGGGTGCTGCCAGCAYGGTTC

1007 T>C (p.Met743Thr) 10020 GNE TGGACTACACAACACGCAGG]

NM_004273.4(CHST3):c.776T> ['CGCTGCGGCCCCCTCAACGTGACGCYGGCC

1008 C (p.Leu259Pro) 9469 CHST3 GCAGAGGCCTGCCGCCGCAAG]

NM_004273.4(CHST3):c.920T> ['CTGGTGCGCGACCCCCGGGCCGTGCYGGCC

1009 C (p.Leu307Pro) 9469 CHST3 TCGCGCATGGTGGCCTTCGCC]

NM_004273.4(CHST3):c.857T> ['CGGCAGCTGGAGTTCCTGCAGCCGCYGGCC

1010 C (p.Leu286Pro) 9469 CHST3 GAGGACCCCCGCCTGGACCTG]

NM_172201.1(KCNE2):c. l61T> ['TTCTACTATGTCATCCTGTACCTCAYGGTGA

1011 C (p.Met54Thr) 9992 KCNE2 TGATTGGAATGTTCTCTTTC']

NM_172201. l(KCNE2):c.170T> ['GTCATCCTGTACCTCATGGTGATGAYTGGAA

1012 C (p.Ile57Thr) 9992 KCNE2 TGTTCTCTTTCATCATCGTG]

NM_172201. l(KCNE2):c.178T> ['GTACCTCATGGTGATGATTGGAATGHTCTCT

1013 C (p.Phe60Leu) 9992 KCNE2 TTCATCATCGTGGCCATCCT']

NM_001139.2(ALOX12B):c.l27 ['TCATCCTCCTTGCTCTCCCCACAGCYCCTCA

1014 7T>C (p.Leu426Pro) 242 ALOX12B TCCCCCATACCCGATACACC]

NM_003640.3(IKBKAP):c.2204 ['ATTCGGAAGTGGTTGGACAAGTAAGYGCCA

1015 +6T>C 8518 KBKAP TTGTACTGTTTGCGACTAGTT']

NM_005413.3(SIX3):c.749T>C ['GCCACCGGCCTCACTCCCACACAAGYAGGC

1016 (p.Val250Ala) 6496 SIX3 AACTGGTTTAAGAACCGGCGG]

NM_004820.3(CYP7Bl):c.647T [TTTATTAGTGAGCTAAGAGATGATTYTTTAA

1017 >C (p.Phe216Ser) 9420 CYP7B1 AATTTGATGACAAGTTTGCA']

1018 NM_194248.2(OTOF):c.3032T> 9381 OTOF ['CTGTGTCCCACCTGGGACCAGATGCYGGTGT C fp.LeulOl lPro) TCGACAACCTGGAGCTCTAT']

NM_194248.2(OTOF):c.1544T> ['GACGTGGCCATCGGCACCCACTTCAYTGACC

1019 C (p.Ile515Thr) 9381 OTOF TGCGCAAGATTTCTAATGAC]

NM_004737.4(LARGE):c.l483T ['GATGCTGGAGGCCATCTGCAAGCACYGGGA

1020 >C (p.Trp495Arg) 9215 LARGE GGGGCCCATCAGCCTGGCCCT']

NM_002420.5 (TRPM1 ) : c.296T> ['GAGGCCTCCATGCACAGATATTAAGRGCTTG

1021 C (p.Leu99Pro) 4308 TRPM1 GGGAGTTCCAGCTGCCAATC]

NM_004700.3 (KCNQ4) : c.842T> ['ACCTGTTTGTGTCTCCAGATTACATYGACAA

1022 C (p.Leu281Ser) 9132 KCNQ4 CCATCGGCTATGGTGACAAG]

NM_003839.3(TNFRSFl lA):c.5 TNFRSF11 ['ACTGAACCACCTTTTCCCCCACAGCYGTACC

1023 23T>C (p.Cysl75Arg) 8792 A TTCCTTGGAAAGAGAGTAGA']

NM_030761.4(WNT4):c.35T>C ['CGCTCGTGCCTGCGTTCGCTGCGCCYCCTCG

1024 (p.Leul2Pro) 54361 WNT4 TCTTCGCCGTCTTCTCAGCC]

NM_000050.4(ASSl):c.535T>C ['CATCCCGGTCACTCCCAAGAACCCGYGGAG

1025 (p.Trpl79Arg) 445 ASS1 CATGGATGAGAACCTCATGCA']

NM_002977.3(SCN9A):c.2543T ['ACATTGAACATGCTGATTAAGATCAYTGGTA

1026 >C (p.Ile848Thr) -1 - ACTCAGTAGGGGCTCTAGGT']

NM_002977.3 (SCN9 A) :c.4382T ['TTTCTTTACCTTGGAGGTCAAGACAYCTTTA

1027 >C (p.Ilel461Thr) -1 - TGACAGAAGAACAGAAGAAA']

NM_002977.3 (SCN9 A) :c.647T> ['GGCAATGTTTCAGCTCTTCGAACTTYCAGAG

1028 C (p.Phe216Ser) 6335 SCN9A TATTGAGAGCTTTGAAAACT']

NM_003880.3(WISP3):c.232T> ['AGATGGCTGTGGATGCTGTAAAATCYGTGC

1029 C (p.Cys78Arg) 8838 WISP3 CAAGCAACCAGGGGAAATCTG]

NM_003880.3(WISP3):c.l000T> ['TAAATGGAAGATGCTGTGGATTACAYCTTGT

1030 C (p.Ser334Pro) 8838 WISP3 GTGTGTCAGAGAAACTGCAG]

NM_001457.3(FLNB):c.703T>C ['CGAGCACTCAGTTATGACTTACCTGYCCCAG

1031 (p.Ser235Pro) 2317 FLNB TTCCCCAAAGCCAAGCTCAA']

['GATTTGTTACTGACAAGGCCTAGGGNAAGTT

TTCACAGCCTAAAACACAGT',

'TACAAGACCTAAGTTCCAAGAAGCARCAGTC

CCACAACATTCTGGATCTGC,

'GGTCACCATCATGTCCATAATGCTGYGGTAT

GTAAAAGAGACCTGCCTGAG,

ATGCCTCAGACAAAATTCAAAGCCTRTGTCA

1032 TCAGAGAGTGAAAAGGATAT',

NM_003060.3(SLC22A5):c. l051 'GGCTGTTGTGGGAAATATGGACTCTYGTGGG 1036 T>C (p.Trp351Arg) 6584 SLC22A5 GAATCTCTCCAGATCTTAAG']

NM_000369.2(TSHR):c. l891T> ['TGCCAAGAGGATGGCTGTGTTGATCYTCACC

1037 C (p.Phe631Leu) 7253 TSHR GACTTCATATGCATGGCCCC]

NM_000369.2(TSHR):c. l358T> ['AAACTGAACGTCCCCCGCTTTCTCAYGTGCA

1038 C (p.Met453Thr) 7253 TSHR ACCTGGCCTTTGCGGATTTC]

NM_000369.2(TSHR):c.1526T> ['ACTGTCTTTGCAAGCGAGTTATCGGYGTATA

1039 C (p.Val509Ala) 7253 TSHR CGCTGACGGTCATCACCCTG]

1040 NM_000369.2(TSHR):c.1798T> 7253 TSHR ['AGTTGCCTTCGTCATCGTCTGCTGCYGTTAT C (p.Cys600Arg) GTGAAGATCTACATCACAGT']

NM_000369.2(TSHR):c.1400T> ['GCGGATTTCTGCATGGGGATGTACCYGCTCC

1041 C (p.Leu467Pro) 7253 TSHR TCATCGCCTCTGTAGACCTC]

NM_001003722.1(GLEl):c.2051 ['CAGAAATGTTTGCAACACAAGGACAYTCCT

1042 T>C (p.Ile684Thr) 2733 GLE1 GTCCCCAAGGGCTTTCTGACT']

NM_024009.2(GJB 3 ) :c .101 T>C ['TCCGTGGTGTTCGTCTTCCGGGTGCYGGTAT

1043 (p.Leu34Pro) 2707 GJB3 ACGTGGTGGCTGCAGAGCGC]

NM_001080463.1(DYNC2Hl):c. ['GATTTGCTCAGAGTAGCTGATACAAYTGTAG

1044 3719T>C (p.Ilel240Thr) 79659 DYNC2H1 CCAAAGCTGCCGACCTTAAA']

NM_018129.3 (PNPO) : c.784T>C ['CTGGCTCTATGAGAGACTTGCACCTYAACTC

1045 (p.Ter262Gln) 55163 PNPO TGGGACCTGCTGGCCCAGAG]

NM_003722.4(TP63):c.l033T>C ['CCGACGCTGCTTTGAGGCCCGGATCYGTGCT

1046 (p.Cys345Arg) 8626 TP63 TGCCCAGGAAGAGACAGGAA']

NM_003722.4(TP63):c.l646T>C ['CCTCCGTATCCCACAGATTGCAGCAYTGTCA

1047 (p.Ile549Thr) 8626 TP63 GGTGAGTCCACAGCATGTGC]

NM_003722.4(TP63):c.l738T>C ['CACCATCTATCAGATTGAGCATTACBCCATG

1048 (p.Ser580Pro) 8626 TP63 GATGTAAGTAACTGTTAGAC]

NM_004086.2(COCH):c.349T>C ['CATCCAGTCTCAAATGCTTTCTAGAYGGTCT

1049 (p.Trpl l7Arg) -1 - GCTTCTTTCACAGTAACTAG]

NM_004086.2(COCH):c.l535T> ['GCACCTCTGGATGACCTGAAAGATAYGGCT

1050 C (p.Met512Thr) -1 - TCTAAACCGAAGGAGTCTCAT']

NM_006412.3(AGPAT2):c.683T ['ACAGGAACAGTCACAGTGCAGGTGCYGGAA

1051 >C (p.Leu228Pro) 10555 AGPAT2 GCCATCCCCACCAGCGGCCTC]

NM_003659.3(AGPS):c. l406T> ['AATCAGCTAAGTGTAGCCACATTACYGTTTG

1052 C (p.Leu469Pro) 8540 AGPS AGGGGGATCGTGAGAAGGTT']

NM_004550.4(NDUFS2):c.l237 ['GGGAGAGTTTGGGGTGTACCTGGTGYCTGA

1053 T>C (p.Ser413Pro) 4720 NDUFS2 TGGCAGCAGCCGCCCTTATCG]

NM_006892.3(DNMT3B):c.808 ['CCAGTGGTTTGGCGATGGCAAGTTCYCCGA

1054 T>C (p.Ser270Pro) 1789 DNMT3B GGTGAGTCCGGGGAAGGGCAA']

NM_002538.3(OCLN):c.656T>C 10050 ['CAAATATATGCCCTCTGCAACCAATYTTATA

1055 (p.Phe219Ser) 6658 OCLN CACCTGCAGCTACTGGACTC]

NM_001211.5(BUBlB):c.3035T ['AATGATGAGGCCACAGTGTCTGTTCYTGGG

1056 >C (p.Leul012Pro) -1 - GAGCTTGCAGCAGAAATGAAT']

NM_016203.3 (PRKAG2) :c .1459 ['ACAGAATCTTGCTGCTGAGAAAACAYACAA

1057 T>C (p.Tyr487His) 51422 PRKAG2 TAACCTAGATATCACGGTGAC]

NM_016203.3 (PRKAG2) :c .1642 ['TAGTATTGTGGGTATTATTTCCCTGYCGGAC

1058 T>C (p.Ser548Pro) 51422 PRKAG2 ATTCTGCAAGCCCTGATCCT']

NM_001287.5(CLCN7):c.2297T ['TTCAAGCTGTTCCGGGCCCTGGGCCYGCGGC

1059 >C (p.Leu766Pro) 1186 CLCN7 ACCTGGTGGTGGTGGACAAC]

M_004646.3(NPHSl):c.793T> ['GGCAGGACAGAGCTTGGAGCTGCCGYGCGT

1060 C (p.Cys265Arg) 4868 NPHS1 GGCCCGAGGGGGTAATCCCTT']

NM_003002.3(SDHD):c.416T>C ['CTTTCAGCTTTAACCTTTGCTGGGCYTTGCT

1061 (p.Leul39Pro) 6392 SDHD ATTTCAACTATCACGATGTG]

1062 NM_001164277.1(SLC37A4):c.3 2542 SLC37A4 ['TAATGGCCTGGCCCAGGGGCTGGGCYGGCC 52T>C (p.Tipl l8Arg) CCCATGTGGGAAGGTCCTGCG']

NM_002546.3(TNFRSFl lB):c.3 TNFRSF11 ['GGAAGGGCGCTACCTTGAGATAGAGYTCTG

1063 49T>C (p.Phel l7Leu) 4982 B CTTGAAACATAGGAGCTGCCC]

NM_005422.2(TECTA):c.5509T ['GGGCGTGAGGATCAATGACAGACAGBGCAC

1064 >C (p.Cysl837Arg) 7007 TECTA CGGCATCGAGGGGGAAGATTT']

NM_007262.4(P ARK7) : c.497T> ['CCTGGGACCAGCTTCGAGTTTGCGCYTGCAA

1065 C (p.Leul66Pro) 11315 PARK7 TTGTTGAAGCCCTGAATGGC]

NM_006009.3(TUBAlA):c.l l90 ['GCTCGCCTGGACCACAAGTTTGACCYGATGT

1066 T>C (p.Leu397Pro) 7846 TUBA1A ATGCCAAACGTGCCTTTGTT']

NM_002700.2(POU4F3):c.668T ['CTCAAGATCCCCGGCGTGGGCTCGCYGAGC

1067 >C (p.Leu223Pro) 5459 POU4F3 CAAAGCACCATCTGCAGGTTC]

NM_005025.4(SERPINIl):c.l45 ['TGGTGAAGATGAAAATATTCTCTTCYCTCCA

1068 T>C (p.Ser49Pro) 5274 SERPINI1 TTGAGTATTGCTCTTGCAAT']

NM_001040667.2(HSF4):c.341T ['TTCGTGCGCGGCCGCGAGCAGCTACYGGAG

1069 >C (p.Leul l4Pro) 3299 HSF4 CGCGTGCGGCGCAAGGTGGGG]

NM_002942.4(ROBO2):c.2834T ['AATAGCAACAGTGGCCCAAATGAGAYTGGA

1070 >C (p.Ile945Thr) 6092 ROB02 AATTTTGGCCGTGGAGGTAAG]

NM_000492.3(CFTR):c.3857T> ['ACTTTGCAACAGTGGAGGAAAGCCTYTGGA

1071 C (p.Phel286Ser) 1080 CFTR GTGATACCACAGGTGAGCAAA]

NM_000492.3(CFTR):c.3763T> ['TGGATCAGGGAAGAGTACTTTGTTAYCAGCT

1072 C (p.Serl255Pro) 1080 CFTR TTTTTGAGACTACTGAACAC]

NM_000492.3 (CFTR) :c .3194T> ['ACAAGCTTAAAAGGACTATGGACACBTCGT

1073 C (p.Leul065Pro) 1080 CFTR GCCTTCGGACGGCAGCCTTAC]

NM_000492.3(CFTR):c.3469- ['TGTCTGCCATTCTTAAAAACAAAAAYGTTGT

1074 20T>C 1080 CFTR TATTTTTATTTCAGATGCGA']

NM_005603.4(ATP8Bl):c.863T ['TTTTGGAGAAACACAAGTTTTCCTTYGGATG

1075 >C (p.Leu288Ser) 5205 ATP8B1 CTGATAAAATTTTGTTACGT']

NM_005603.4(ATP8Bl):c.2097+ ['GAGGAGATTGAAAAAGACTTAATTGYGAGT

1076 2T>C 5205 ATP8B1 TTTAGCCTTAATAACTTTTTC]

NM_005603.4(ATP8Bl):c.l982 ['ACCCTATGCCTTTGCTACAAGGAAAYTGAA

1077 T>C (p.Ile661Thr) 5205 ATP8B1 GAAAAAGAATTTACAGAATGG]

['CGCAGCACGGAGTCTCGGCGTCCCAYGGCG

1078 M_005144.4(HR):c.-320T>C 55806 HR CAACCTACGGCCTCGGCCCAG]

NM_003322.4(TULPl):c.l471T ['GGTCACCCAGGCCTCAGTCAAGAACYTCCA

1079 >C (p.Phe491Leu) 7287 TULP1 GATTGTCCACGCTGATGACCG]

NM_003322.4(TULPl):c.l l45T ['CTCCTGGGGAACCGCTTCACGGTCTYTGACA

1080 >C (p.Phe382Ser) 7287 TULP1 ACGGGCAGAACCCACAGCGT']

NM_000455.4(STKl l):c.200T> ['TCTTACGGCAAGGTGAAGGAGGTGCYGGAC

1081 C (p.Leu67Pro) 6794 STK11 TCGGAGACGCTGTGCAGGAGG]

NM_002241.4(KCNJ10):c.418T ['TGGCTTCCGCTACATCAGTGAGGAAYGTCCA

1082 >C (p.Cysl40Arg) 3766 KCNJ10 CTGGCCATTGTGCTTCTTAT']

NM_001172567.1(MYD88):c.31 ['TCTGTAGGCCGACTGCTCGAGCTGCYTACCA

1083 7T>C (p.Leul06Pro) 4615 MYD88 AGCTGGGCCGCGACGACGTG]

1084 NM_000466.2(PEXl):c.l991T> 5189 PEX1 ['CCATCTGTTGTCCTGCTGGATGACCYTGACC C (p.Leu664Pro) TCATTGCTGGACTGCCTGCT']

NM_001303.3(COX10):c.2T>C ['GGAGCGGCCCCAGACTCGTAAATTAYGGCC

1085 (p.MetlThr) 1352 COX10 GCATCTCCGCACACTCTCTCC]

NM_001300.5 (KLF6) : c.346T>C ['TGTCAGCAGCGAATCCTCTGACAGCYCCGA

1086 (p.Serl l6Pro) 1316 KLF6 GGAACTTTCTCCCACGGCCAA']

NM_001300.5 (KLF6) : c.190T>C ['CAAATTTGACAGCCAGGAAGATCTGYGGAC

1087 (p.Trp64Arg) 1316 KLF6 CAAAATCATTCTGGCTCGGGA]

NM_001300.5 (KLF6) : c.506T>C ['CTGTGGGGTTGCGTGCCCGGGGAGCYGCCC

1088 (p.Leul69Pro) 1316 KLF6 TCGCCAGGGAAGGTGCGCAGC]

NM_000085.4(CLCNKB):c. l294 ['CGGGTACTTCATGCCCATCTTTGTCYATGGT

1089 T>C (p.Tyr432His) 1188 CLCN B GAGTCTGGGGTCCTGAGGTT']

NM_000214.2(JAGl):c.110T>C ['TGTGGGGCCTCGGGTCAGTTCGAGTYGGAG

1090 (p.Leu37Ser) 182 JAG1 ATCCTGTCCATGCAGAACGTG]

NM_003865.2(HESXl):c.77T>C ['ACTTGCTCCTTTTCAATTGAGAGAAYCTTAG

1091 (p.Ile26Thr) 8820 HESX1 GACTGGACCAGAAGAAAGAC]

NM_003865.2(HESXl):c.357+2 ['TCATTATTGGGTGAAAAAACTTCCCDCCTGG

1092 T>C 8820 HESX1 TTTTGAGTAAAAGCAGTTCT']

NM_002618.3 (PEX 13 ) :c .977T> ['CTTGATGGCCAAACAACAGGACTTAYACCT

1093 C (p.Ile326Thr) 5194 PEX 13 GCGAATTATGTCAAAATTCTT']

NM_000303.2(PMM2):c.395T> ['AATGGGATGTTAAACGTGTCCCCTAYTGGA

1094 C (p.Ilel32Thr) 5373 PMM2 AGAAGCTGCAGCCAAGAAGAA']

NM_000303.2(PMM2):c.l31T> ['AGGCAGAAGATCAAAATCGGAGTGGYAGGC

1095 C (p.Val44Ala) 5373 PMM2 GGATCGGACTTTGAGAAAGTG]

NM_000104.3(CYPlBl):c.2T>C ['CGCCTTCTCCTCTCTGTCCCCAGCAYGGGCA

1096 (p.MetlThr) 1545 CYP1B1 CCAGCCTCAGCCCGAACGAC]

NM_032977.3(CASP10):c.440T ['AAAGACTCGCTTCCCAAAACTGAAAYGGTG

1097 >C (p.Metl47Thr) 843 C ASP 10 AGTGGGTCATACAGAATGGGT']

NM_003999.2(OSMR):c.2072T> ['GGTTCAGAATGTTGCAAATACAAAAYTGAC

1098 C (p.Ile691Thr) 9180 OSMR AACCCGGAAGAAAAGGCATTG]

NM_000314.6(PTEN):c.370T>C ['TGACAATCATGTTGCAGCAATTCACBGTAAA

1099 (p.Cysl24Arg) 5728 PTEN GCTGGAAAGGGACGAACTGG]

NM_000314.6(PTEN):c.209T>C ['AAAAACCATTACAAGATATACAATCYGTAA

1100 (p.Leu70Pro) 5728 PTEN GTATGTTTTCTTATTTGTATG]

NM_000314.6(PTEN):c.335T>C ['TTTTGTGAAGATCTTGACCAATGGCYAAGTG

1101 (p.Leull2Pro) 5728 PTEN AAGATGACAATCATGTTGCA']

NM_000314.6(PTEN):c.722T>C ['CGACGGGAAGACAAGTTCATGTACTYTGAG

1102 (p.Phe241Ser) 5728 PTEN TTCCCTCAGCCGTTACCTGTG]

NM_006949.3(STXBP2):c.626T ['TTGGCCCACGCCGTCCTGGCCAAGCHGAAC

1103 >C (p.Leu209Pro) 6813 STXBP2 GCCTTCAAGGCAGACACTCCC]

NM_000358.2(TGFBI):c. l619T> ['AACCGGGAAGGAGTCTACACAGTCTYTGCT

1104 C (p.Phe540Ser) 7045 TGFBI CCCACAAATGAAGCCTTCCGA']

NM_000350.2(ABCA4):c.l622T ['CAGCTCACCCAACGTGCCCTCTCTCYACTGG

1105 >C (p.Leu541Pro) 24 ABCA4 AGGAAAACATGTTCTGGGCC]

1106 NM_000350.2(ABCA4):c.5819T 24 ABCA4 ['GGAAATAAAACTGACATCTTAAGGCYACAT >C (p.Leul940Pro) GAACTAACCAAGGTAAGGGAA]

NM_000860.5(HPGD):c.577T>C ['CTTTGTTAACACAGCCATCCTTGAAYCAATT

1107 (p.Serl93Pro) 3248 HPGD GAAAAAGAAGAAAACATGGG]

NM_000223.3 (KRT 12) :c .386T> ['CTTTCTGGATCAGAAAAAGAAACTAYGCAA

1108 C (p.Metl29Thr) 3859 KRT12 AATCTTAATGATAGATTAGCT']

NM_000503.5(EYAl):c.l459T> ['GTTGACACTGGCCCTGAAAGCACTCYCGCTC

1109 C (p.Ser487Pro) 2138 EYA1 ATTCACTCCCGGTGAGGCTC]

NM_000261.1(MYOC):c.l309T ['TGCCTTCATCATCTGTGGCACCTTGYACACC

1110 >C (p.Tyr437His) 4653 MYOC GTCAGCAGCTACACCTCAGC]

NM_000261.1(MYOC):c.l297T ['GTCAGTCGCCAATGCCTTCATCATCYGTGGC

1111 >C (p.Cys433Arg) 4653 MYOC ACCTTGTACACCGTCAGCAG]

NM_130838.1(UBE3A):c.389T> ['GATTATTCCCCTTTAATCCGTGTTAYTGGAA

1112 C (p.Ilel30Thr) 7337 UBE3A GAGTTTTTTCTAGTGCTGAG]

M_000474.3 (TWIST 1 ) : c.392T ['TCGCTGAACGAGGCGTTCGCCGCGCYGCGG

1113 >C (p.Leul31Pro) 7291 TWIST 1 AAGATCATCCCCACGCTGCCC]

NM_000192.3(TBX5):c.l61T>C ['TCCTTCTTGCAGGGCATGGAGGGAAYCAAA

1114 (p.Ile54Thr) 6910 TBX5 GTGTTTCTCCATGAAAGAGAA]

NM_002905.3(RDH5):c.841T>C ['GACTGCTCGACACCCCCGAACCCGCBACAG

1115 (p.Tyr281His) -1 - CCCAGGTTGGGATGCCAAGCT']

NM_001089.2(ABCA3):c.302T> ['GTCACTGAGACAGTGCGCAGGGCACYTGTG

1116 C (p.LeulOlPro) 21 ABC A3 ATCAACATGCGAGGTGAGACA']

NM_001089.2(ABCA3):c.4658T ['ATGGACCCCGTGGCCCGGCGCCTGCYTTGG

1117 >C (p.Leul553Pro) 21 ABC A3 GACACCGTGGCACGAGCCCGA']

NM_001089.2(ABCA3):c.977T> ['ATCGCCGCCTCCTTCATGACCCTGCYCTTCT

1118 C (p.Leu326Pro) 21 ABC A3 GTGTCAAGGTGAGCATGGCG]

NM_005535.2(IL12RBl):c.592T ['CTGCCTCTCCCCAGAGTCCTGCCTCYGCCCC

1119 >C (p.Cysl98Arg) 3594 IL12RB1 CTGGAGATGAATGTGGCCCA]

NM_005055.4(RAPSN):c.41T>C ['ACCAAGCAGCAGATCGAGAAGGGGCYCCAG

1120 (p.Leul4Pro) 5913 RAPSN CTGTACCAGTCCAACCAGACA]

NM_005055.4(RAPSN):c.848T> ['ATCATGACCGAGATCGGAAACCGCCYGGGG

1121 C (p.Leu283Pro) 5913 RAPSN CAGGTGCAGGCGCTGCTGGGT']

NM_005055.4(RAPSN):c.416T> ['AATGCCTTCCTGGGCCTCAGCGTCTYCCAGA

1122 C (p.Phel39Ser) 5913 RAPSN AGGCCCTGGAGAGCTTCGAG]

NM_005570.3(LMANl):c.2T>C ['CTCCTCCGCGTTCCAGAATCCAAGAYGGCG

1123 (p.MetlThr) 3998 LMAN1 GGATCCAGGCAAAGGGGTCTC]

NM_000430.3(PAFAHlBl):c.50 PAFAHIB ['CAGCGGCAAGCTTCTGGCTTCCTGTYCTGCA

1124 5T>C (p.Serl69Pro) 5048 1 GATATGACCATTAAACTATG]

NM_000430.3(PAFAHlBl):c92 PAFAHIB ['GGCTATGAAGAGGCATATTCAGTTTYTAAA

1125 T>C (p.Phe31Ser) 5048 1 AAGGAAGCTGAATTAGATGTG]

NM_006261.4(PROPl):c.263T> ['CAGTTGGAACAGCTGGAGTCAGCCTYTGGG

1126 C (p.Phe88Ser) 5626 PROP1 AGGAACCAGTACCCCGACATC]

NM_175929.2(FGF14):c.449T> ['GAACTTTTTACCCCTGAATGCAAGTYTAAAG

1127 C (p.Phel50Ser) 2259 FGF14 AATCTGTTTTTGAAAATTAT']

1128 NM_004970.2(IGFALS):c.l618T 3483 IGFALS ['GTGGCTGGAGGGTAACCCCTGGGACYGTGG >C (p.Cys540Arg) CTGCCCTCTCAAGGCGCTGCG]

NM_005379.3 (MYO 1 A) : c.2728 ['CCCTTGCCTGTTCCGTCCCTAGACTYCTTCTC

1129 T>C (p.Ser910Pro) 4640 MY01A GGATTCTCCTCCTGACCAA]

NM_006302.2(MOGS):c. l954T> ['GCACTGGGCCCCAGAGCTAGGAGTCYTTGC

1130 C (p.Phe652Leu) 7841 MOGS AGACTTTGGGAACCACACAAA']

NM_001009944.2(PKDl):c.2534 ['TACGTGCCCACCAACGGCTCAGCCTYGGTGC

1131 T>C (p.Leu845Ser) 5310 PKD1 TCCAGGTGGACTCTGGTGCC]

NM_004329.2(BMPRlA):c.370T ['AGCCCAGCTACGCCGGACAATAGAAYGTTG

1132 >C (p.Cysl24Arg) 657 BMPR1A TCGGACCAATTTATGTAACCA']

NM_004329.2(BMPR1 A):c.1409 ['CCGAGTGATCCGTCATACGAAGATAYGCGT

1133 T>C (p.Met470Thr) 657 BMPR1A GAGGTTGTGTGTGTCAAACGT']

NM_000452.2(SLC10A2):c.728 ['GTGGCGGGTTACTCCCTGGGGTTTCYTCTGG

1134 T>C (p.Leu243Pro) 6555 SLC10A2 CTAGAATTGCTGGTCTACCC]

NM_030662.3 (MAP2K2) : c.400T ['CAACTCGCCGTACATCGTGGGCTTCYACGGG

1135 >C (p.Tyrl34His) 5605 MAP2K2 GCCTTCTACAGTGACGGGGA']

NM_033337.2(CAV3):c.260T>C ['CTGCTGGGCGTCCCACTGGCCCTGCHCTGGG

1136 (p.Leu87Pro) 859 CAV3 GCTTCCTGTTCGCCTGCATC]

NM_000388.3 (CASR) : c.2417T> ['CCGGAGAACTTCAATGAAGCCAAGTHCATC

1137 C (p.Phe806Ser) 846 CASR ACCTTCAGCATGCTCATCTTC]

NM_000388.3 (CASR) : c.382T>C ['AATTGATTCTTTGAACCTTGATGAGYTCTGC

1138 (p.Phel28Leu) 846 CASR AACTGCTCAGAGCACATTCC]

NM_000388.3(CASR):c. l835T> ['GAGTTTCTGTCGTGGACGGAGCCCTYTGGGA

1139 C (p.Phe612Ser) 846 CASR TCGCACTCACCCTCTTTGCC]

NM_000388.3 (CASR) : c.2641 T> ['GCGTTGCAGCACCGCAGCTCACGCTYTCAA

1140 C (p.Phe881Leu) 846 CASR GGTGGCTGCCCGGGCCACGCT']

NM_000388.3(CASR):c.374T>C ['CAAAACAAAATTGATTCTTTGAACCYTGATG

1141 (p.Leul25Pro) 846 CASR AGTTCTGCAACTGCTCAGAG']

NM_000388.3 (C ASR) : c.2362T> ['CACCTGCCTGCTGGCTGCCATCTGCYTCTTC

1142 C (p.Phe788Leu) 846 CASR TTTGCCTTCAAGTCCCGGAA']

NM_000388.3 (C ASR) : c.38T>C ['AGCTGCTGCTGGGTCCTCTTGGCACYCACCT

1143 (p.Leul3Pro) 846 CASR GGCACACCTCTGCCTACGGG]

NM_030653.3(DDXl l):c.2271+ ['CTGGCATATTCCAGGTGCATCCAGGYGCGG

1144 2T>C 1663 DDX11 GCGTCATGCTGGGCTTGGGTC]

NM_001001557.2(GDF6):c.866T 39225 ['TTCACCAGATCCCAGCGCAAGAACCYGTTC

1145 >C (p.Leu289Pro) 5 GDF6 GCAGAGATGCGCGAGCAGCTG]

NM_000557.4(GDF5):c.1322T> ['TGCGAGTTCCCATTGCGCTCCCACCYGGAGC

1146 C (p.Leu441Pro) -1 - CCACGAATCATGCAGTCATC]

NM_000392.4(ABCC2):c. l967+ ['TGATTCGGAAGCCACAGTCCGAGAGYGAGT

1147 2T>C 1244 ABCC2 TGCCTTCTTTCCATCCTAATG]

NM_000396.3(CTSK):c.926T>C ['AACTGGGGAAACAAAGGATATATCCYCATG

1148 (p.Leu309Pro) 1513 CTSK GCTCGAAATAAGAACAACGCC]

NM_000304.3(PMP22):c.47T>C ['ATCATCGTCCTCCACGTCGCGGTGCYGGTGC

1149 (p.Leul6Pro) 5376 PMP22 TGCTGTTCGTCTCCACGATC]

1150 NM_000304.3 (PMP22) : c.82T>C 5376 PMP22 ['ATATCTATCTGATTCTCTCTAGCAAYGGATC (p.Trp28Arg) GTGGGCAATGGACACGCAAC]

NM_001453.2(FOXCl):c.335T> ['ATCTACCAGTTCATCATGGACCGCTHCCCCT

1151 C (p.Phel l2Ser) 2296 FOXC1 TCTACCGGGACAACAAGCAG]

NM_001451.2(FOXFl):c.l l38T ['CCAAGACATCAAGCCTTGCGTGATGYGAGG

1152 >C (p.Ter380Arg) 2294 FOXF1 CTGCCGCCGCAGGCCCTCCTG]

NM_006432.3(NPC2):c.l99T>C ['CTCTTTTTTTCTCTTAGATATTCAGYCTAAAA

1153 (p.Ser67Pro) 10577 NPC2 GCAGCAAGGCCGTGGTGCA']

NM_001127221.1 (C ACNA1 A) :c ['CTGAATGTGTTCTTGGCCATCGCTGYGGACA

1154 .2141T>C (p.Val714Ala) 773 CACNA1A ATCTGGCCAACGCCCAGGAG]

NM_001127221.1 (C ACNA1 A) :c ['GGGTACCGCATGGAGATGTCCATTTYCTACG

1155 .4469T>C (p.Phel490Ser) 773 CACNA1A TCGTCTACTTTGTGGTGTTC']

NM_001127221.1 (C ACNA1 A) :c ['ATGCTCTTCTTCATCTATGCCATCAYTGGGA

1156 .5126T>C (p.Ilel709Thr) 773 CACNA1A TGCAGGTGAGTGTCGTGTCC]

NM_000901.4(NR3C2):c.2771T ['CAGAGCTGGCAGAGGTTCTACCAACYGACC

1157 >C (p.Leu924Pro) 4306 NR3C2 AAGCTGCTGGACTCCATGCAT']

NM_000901.4(NR3C2):c.2936T ['GTGGAGTCGGGGAACGCCAAGCCGCYCTAC

1158 >C (p.Leu979Pro) 4306 NR3C2 TTCCACCGGAAGTGACTGCCC]

NM_000339.2(SLC12A3):c.2576 ['CTCACCCTCCTCATTCCCTATCTCCYTGGCC

1159 T>C (p.Leu859Pro) 6559 SLC12A3 GCAAGAGGAGGTGGAGCAAA']

NM_000339.2(SLC12A3):c. l261 ['CTGGGGTGCCTGCGAGGGGCTGGCCYGCAG

1160 T>C (p.Cys421Arg) 6559 SLC12A3 CTATGGCTGGAACTTCACCGA]

NM_000339.2(SLC12A3):c. l868 [TCGGTACAGGCTGGCTCCTACAACCYGGCCC

1161 T>C (p.Leu623Pro) 6559 SLC12A3 TCAGCTACTCGGTGGGCCTC]

NM_000163.4(GHR):c.341T>C ['TCTGCTGGGGAAAACAGCTGTTACTYTAATT

1162 (p.Phel l4Ser) 2690 GHR CATCGTTTACCTCCATCTGG]

NM_000163.4(GHR):c.512T>C ['AGTTTAACTGGGATTCATGCAGATAYCCAA

1163 (p.Ilel71Thr) 2690 GHR GTGAGATGGGAAGCACCACGC]

NM_000525.3(KCNJll):c.440T ['ACTGAGGAGTGCCCACTGGCCATCCYGATC

1164 >C (p.Leul47Pro) 3767 KCNJ11 CTCATCGTGCAGAACATCGTG]

NM_000525.3(KCNJll):c.l24T ['CCGCTTTGTGTCCAAGAAAGGCAACYGCAA

1165 >C (p.Cys42Arg) 3767 KCNJ11 CGTGGCCCACAAGAACATCCG]

NM_001122764.1 (PPOX) :c .35T ['ACCGTGGTCGTGCTGGGCGGAGGCAYCAGC

1166 >C (p.Ilel2Thr) 5498 PPOX GGCTTGGCCGCCAGTTACCAC]

NM_000182.4(H ADH A) : c.1025 ['AAAGAATCAAAGGCCTTGATGGGACYCTAC

1167 T>C (p.Leu342Pro) 3030 HADHA CATGGTCAGGTCCTGTGCAAG]

NM_003476.4(CSRP3):c.l31T> ['CTGGCAGTGGCCTGCAGGAAGGCTCYTGAC

1168 C (p.Leu44Pro) 8048 CSRP3 AGCACGACAGTCGCGGCTCAT']

NM_001204.6(BMPR2):c.367T> ['TTTCTGCTGTTGTAGCACAGATTTAHGTAAT

1169 C (p.Cysl23Arg) 659 BMPR2 GTCAACTTTACTGAGAATTT']

NM_000336.2(SCNNlB):c. l858 ['CATCCCAGGCACCCCGCCCCCCAACYATGA

1170 T>C (p.Tyr620His) 6338 SCNN1B CTCCCTGCGTCTGCAGCCGCT']

NM_002181.3(IHH):c.569T>C ['TCAAAGGCCCACGTGCATTGCTCCGYCAAGT

1171 (p. Vail 90 Ala) 3549 IHH CCGGTGAGCCGCCGCCGGGG]

1172 NM_000193.3 (SHH) : c.349T>C 6469 SHH ['TTTGGCCATCTCGGTGATGAACCAGBGGCCA (p.Trpl l7Arg) GGAGTGAAACTGCGGGTGAC]

NM_000193.3 (SHH):c.995T>C ['GACCGCCGGCTCCTGCCCGCCGCTGYGCAC

1173 (p.Val332Ala) 6469 SHH AGCGTGACCCTAAGCGAGGAG]

NM_000179.2(MSH6):c.2633T> ['AAAATTATAGGGATCATGGAAGAAGBTGCT

1174 C (p.Val878Ala) 2956 MSH6 GATGGTTTTAAGTCTAAAATC]

NM_000098.2(CPT2):c.l342T> ['AACCCTCACTATTGACTGCGTCCAGYTTCAG

1175 C (p.Phe448Leu) 1376 CPT2 AGAGGAGGCAAAGAATTCCT']

NM_007315.3(STATl):c.2117T ['GGAACTGGATATATCAAGACTGAGTYGATT

1176 >C (p.Leu706Ser) 6772 STAT1 TCTGTGTCTGAAGTGTAAGTG]

NM_007315.3(STATl):c. l799T ['AAGGACCAGCAGCCGGGGACCTTCCYGCTG

1177 >C (p.Leu600Pro) 6772 STAT1 CGGTTCAGTGAGAGCTCCCGG]

NM_024420.2(PLA2G4A):c.331 ['AGGGACAGCAACATTTACTGTATCTYCTATG

1178 T>C (p.Serl l lPro) 5321 PLA2G4A AAGGTGGGAGAAAAGAAAGA]

NM_000352.4(ABCC8):c.394T> ['CTATCACAACATCGAGACTTCCAACBTCCCC

1179 C (p.Phel32Leu) 6833 ABCC8 AAGCTGCTAATTGGTAGGTG]

NM_033163.3(FGF8):c.l l8T>C ['GCTGGGCAGGGAGCTCGCTTCCCTGYTCCGG

1180 (p.Phe40Leu) 2253 FGF8 GCTGGCCGGGAGCCCCAGGG]

NM_153767.3(KCNJl):c.l013T ['AACATCTTTCTCATTATAAAGGCACRTGGCA

1181 >C (p.Met338Thr) 3758 KCNJ1 CAGTGAGGGGTCTCCACTTC]

NM_000095.2(COMP):c.982T> ['AACCCACCCTGTCATCCAGGACAACYGCCC

1182 C (p.Cys328Arg) 1311 COMP GCTGGTGCGGAACCCAGACCA']

NM_000095.2(COMP):c.l042T> ['GGACGAGGACAAGTGGGGCGATGCGYGCGA

1183 C (p.Cys348Arg) 1311 COMP CAACTGCCGGTCCCAGAAGAA]

NM_002047.2(GARS):c.548T>C ['ATCCTGGAGATCGATTGCACCATGCYCACCC

1184 (p.Leul83Pro) 2617 GARS CTGAGCCAGTTTTAAAGTGA']

NM_000435.2(NOTCH3):c. l363 ['CCTCGACCGCATAGGCCAGTTCACCYGTATC

1185 T>C (p.Cys455Arg) 4854 NOTCH3 TGTATGGCAGGTGGGTGGTG]

NM_001166107.1(HMGCS2):c.5 ['CTGCTACGGTGGTACTGCCTCCCTCYTCAAT

1186 20T>C (p.Phel74Leu) 3158 HMGCS2 GCTGCCAACTGGATGGAGTC]

NM_001038.5(SCNNlA):c.l477 ['CCAGCTCTCTGCTGGTTACTCACGAYGGCCC

1187 T>C (p.Trp493Arg) 6337 SCNN1A TCGGTGACATCCCAGGTAGA']

NM_000161.2(GCH 1 ) : c.662T>C ['ATGGTAATGCGAGGTGTACAGAAAAYGAAC

1188 (p.Met221Thr) 2643 GCH1 AGCAAAACTGTGACCAGCACA]

NM_000059.3(BRCA2):c.7529T ['CGCGTCTTTCCACAGCCAGGCAGTCYGTATC

1189 >C (p.Leu2510Pro) 675 BRCA2 TTGCAAAAACATCCACTCTG]

NM_000180.3 (GUCY2D) : c.1694 ['GGAGACAGGGTTTGGCTGAAGAAATYCCCA

1190 T>C (p.Phe565Ser) 3000 GUCY2D GGGGATCAGCACATAGCTATC]

NM_000180.3 (GUCY2D) : c.2846 ['AATGGGCAGCGACACGCGGCAGAGAYCGCC

1191 T>C (p.Ile949Thr) 3000 GUCY2D AACATGTCACTGGACATCCTC]

NM_198056.2(SCN5A):c.3963+ ['CTGTCACGATTTGAGGGCATGAGGGYAAGA

1192 2T>C 6331 SCN5A GAGGTGGCTGCCTTCCCACCA']

NM_000335.4(SCN5A):c.5380T ['GAGTGAGGACGACTTCGATATGTTCYATGA

1193 >C (p.Tyrl794His) 6331 SCN5A GATCTGGGAGAAATTTGACCC]

1194 NM_000023.2(SGCA):c.524T>C 6442 SGCA ['CCCGGAGAGCTTCAGCTGCTCAACGYCACCT (p.Vall75Ala) CTGCCTTGGACCGTGGGGGC]

NM_002427.3(MMP13):c.224T> ['AGGCTCCGAGAAATGCAGTCTTTCTYCGGCT

1195 C (p.Phe75Ser) 4322 MMP13 TAGAGGTGACTGGCAAACTT']

NM_002427.3(MMP13):c.221T> ['GAGAGGCTCCGAGAAATGCAGTCTTYCTTC

1196 C (p.Phe74Ser) 4322 MMP13 GGCTTAGAGGTGACTGGCAAA']

NM_002427.3(MMP13):c.272T> ['CTTGACGATAACACCTTAGATGTCAYGAAA

1197 C (p.Met91Thr) 4322 MMP13 AAGCCAAGATGCGGGGTTCCT']

NM_004525.2(LRP2):c.7564T> ['CTCCTTTTGTATGACTAGGTACCTGYACTGG

1198 C (p.Tyr2522His) 4036 LRP2 GCTGACTGGGATACACATGC]

NM_000211.4(ITGB2):c.446T> ['GATGACCTCAGGAATGTCAAGAAGCYAGGT

1199 C (p.Leul49Pro) 3689 ITGB2 GGCGACCTGCTCCGGGCCCTC]

NM_000211.4(ITGB2):c.412T> ['GTACTATCTGATGGACCTCTCCTACYCCATG

1200 C (p.Serl38Pro) 3689 ITGB2 CTTGATGACCTCAGGAATGT']

NM_005502.3(ABCAl):c.4429T ['CAAAATCAAGAAGATGCTGCCTGTGYGTCC

1201 >C (p.Cysl477Arg) 19 ABCAl CCCAGGGGCAGGGGGGCTGCC]

NM_005502.3(ABCAl):c.6026T ['TTGACTGGGAGAGAACACGTGGAGTYCTTT

1202 >C (p.Phe2009Ser) 19 ABCAl GCCCTTTTGAGAGGAGTCCCA']

NM_130439.3(MXIl):c.552+2T ['AACAAAGCCAAAGCACACATCAAGGYGAGA

1203 >C 4601 MXI1 ATTTTTACTTTCAGATTTGCA']

['GTCTTTAGATTTACAGTCCAATGCTYCACTC

1204 m.5874T>C 4579 MT-TY AGCCATTTTACCTCACCCCC]

['CCAACCCCATGGCCTCCATGACTTTYTCAAA

1205 m.7512T>C 4574 MT-TS1 AAGGTATTAGAAAAACCATT']

['AGCCAACCCCATGGCCTCCATGACTYTTTCA

1206 m.7510T>C 4574 MT-TS1 AAAAGGTATTAGAAAAACCA']

['GCCAACCCCATGGCCTCCATGACTTYTTCAA

1207 m.7511T>C 4574 MT-TS1 AAAGGTATTAGAAAAACCAT']

['CCTCCTCAAAGCAATACACTGAAAABGTTTA

1208 m.616T>C 4558 MT-TF GACGGGCTCACATCACCCCA']

['TATCACACCCCATCCTAAAGTAAGGYCAGCT

1209 _m.4409T>C 4569 MT-TM AAATAAGCTATCGGGCCCAT']

['AAAGATTAAGAGAACCAACACCTCTYTACA

1210 m.8356T>C 4566 MT-TK GTGAAATGCCCCAACTAAATA]

['AAAGGATAACAGCTATCCATTGGTCYTAGG

1211 m.l2297T>C 4568 MT-TL2 CCCCAAAAATTTTGGTGCAAC]

['CCGGTAATCGCATAAAACTTAAAACYTTAC

1212 m.3271T>C 4567 MT-TL1 AGTCAGAGGTTCAATTCCTCT']

['GGTTTGTTAAGATGGCAGAGCCCGGYAATC

1213 m.3250T>C 4567 MT-TL1 GCATAAAACTTAAAACTTTAC]

['TAAAACTTTACAGTCAGAGGTTCAAYTCCTC

1214 m.3290T>C 4567 MT-TL1 TTCTTAACAACATACCCATG]

['AAATATGTCTGATAAAAGAGTTACTYTGATA

1215 m.4290T>C 4565 MT-TI GAGTAAATAATAGGAGCTTA]

1216 m.4291T>C 4565 MT-TI ['AATATGTCTGATAAAAGAGTTACTTYGATAG AGTAAATAATAGGAGCTTAA]

['ATCTATTGATGAGGGTCTTACTCTTYTAGTA

1217 m.9997T>C 4563 MT-TG TAAATAGTACCGTTAACTTC]

['GGTCTTACTCTTTTAGTATAAATAGYACCGT

1218 m.l0010T>C 4563 MT-TG TAACTTCCAATTAACTAGTT']

['GCTTAAACCCCCTTATTTCTAGGACYATGAG

1219 m.4336T>C 4572 MT-TQ AATCGAACCCATCCCTGAGA']

['CGGACTACAACCACGACCAATGATAYGAAA

1220 m.l4709T>C 4556 MT-TE AACCATCGTTGTATTTCAACT']

['TCAACAGAAACAAAGCATACATCATBATTCT

1221 _m.14674T>C 4556 MT-TE CGCACGGACTACAACCACGA']

['GGGACTTAAACCCACAAACACTTAGYTAAC

1222 m.5692T>C 4570 MT-TN AGCTAAGCACCCTAATCAACT']

['GCACCCTAATCAACTGGCTTCAATCYACTTC

1223 m.5728T>C 4570 MT-TN TCCCGCCGCCGGGAAAAAAG]

[TCAACAATAGGGTTTACGACCTCGAYGTTGG

1224 m.2991T>C 4550 MT-RNR2 ATCAGGACATCCCGATGGTG]

['ATCTTCAGCAAACCCTGATGAAGGCYACAA

1225 m.l291T>C 4549 MT-RNR1 AGTAAGCGCAAGTACCCACGT']

['CTGGGATTAGATACCCCACTATGCTYAGCCC

1226 m.l095T>C 4549 MT-RNR1 TAAACCTCAACAGTTAAATC]

['TTATAACAAACCCTGAGAACCAAAAYGAAC

1227 m.8528T>C -1 - GAAAATCTGTTCGCTTCATTC]

['AGCCTACTCATTCAACCAATAGCCCBGGCCG

1228 m.8993T>C 4508 MT-ATP6 TACGCCTAACCGCTAACATT']

['ATTAACCTTCCCTCTACACTTATCAYCTTCA

1229 m.9101T>C 4508 MT-ATP6 CAATTCTAATTCTACTGACT']

['ATCCAAGCCTACGTTTTCACACTTCBAGTAA

1230 m.9176T>C 4508 MT-ATP6 GCCTCTACCTGCACGACAAC]

['AAACCTAGCCATGGCCATCCCCTTAYGAGC

1231 m.8851T>C 4508 MT-ATP6 GGGCACAGTGATTATAGGCTT']

['TACGTTTTCACACTTCTAGTAAGCCYCTACC

1232 m.9185T>C 4508 MT-ATP6 TGCACGACAACACATAATGA']

['ATAGGCTAAATCCTATATATCTTAAYGGCAC

1233 m.7587T>C 4513 MT-C02 ATGCAGCGCAAGTAGGTCTA']

['GGTATGGTCTGAGCTATGATATCAAYTGGCT

1234 m.6742T>C 4512 MT-COl TCCTAGGGTTTATCGTGTGA']

['AAAGAACCATTTGGATACATAGGTAYGGTC

1235 m.6721T>C 4512 MT-COl TGAGCTATGATATCAATTGGC]

['CATGAAACATCCTATCATCTGTAGGYTCATT

1236 m.7275T>C 4512 MT-COl CATTTCTCTAACAGCAGTAA']

['CATCAAGCCCGAATGATATTTCCTAYTCGCC

1237 m.l5572T>C 4519 MT-CYB TACACAATTCTCCGATCCGT']

1238 m.l5197T>C 4519 MT-CYB ['GGCCACAGTAATTACAAACTTACTAYCCGCC ATCCCATACATTGGGACAGA]

['CATCTCCGCATGATGAAACTTCGGCYCACTC

1239 m.l4849T>C 4519 MT-CYB CTTGGCGCCTGCCTGATCCT']

['GCTGTAGTATATCCAAAGACAACCAYCATTC

1240 NC_012920.1 :m.14484T>C 4541 MT-ND6 CCCCTAAATAAATTAAAAAA']

['GTAGTATATCCAAAGACAACCATCAYTCCCC

1241 _m.i4487T>C 4541 MT-ND6 CTAAATAAATTAAAAAAACT']

['ATCAGTTCTTCAAATATCTACTCATYTTCCT

1242 m.l2706T>C 4540 MT-ND5 AATTACCATACTAATCTTAG]

['CTCACACCTCATATCCTCCCTACTAYGCCTA

1243 m.l0563T>C 4539 MT-ND4L GAAGGAATAATACTATCGCT']

['ATATTGTGCCTATTGCCATACTAGTYTTTGC

1244 m.l0663T>C 4539 MT-ND4L CGCCTGCGAAGCAGCGGTNG]

['TTACGAGTGCGGCTTCGACCCTATAYCCCCC

1245 m.l0191T>C 4537 MT-ND3 GCCCGCGTCCCTTTCTCCAT']

['ACAACTCAACGGCTACATAGAAAAAYCCAC

1246 m.l0158T>C 4537 MT-ND3 CCCTTACGAGTGCGGCTTCGA']

['CAAGCAACCGCATCCATAATCCTTCYAATAG

1247 m.4681T>C 4536 MT-ND2 CTATCCTCTTCAACAATATA]

['TACCCCCGATTCCGCTACGACCAACYCATAC

1248 m.4160T>C 4535 MT-ND1 ACCTCCTATGAAAAAACTTC]

['GCTTACCGAACGAAAAATTCTAGGCYATAT

1249 m.3394T>C 4535 MT-ND1 ACAACTACGCAAAGGCCCCAA']

['GGTTCAATTCCTCTTCTTAACAACABACCCA

1250 m.3308T>C 4535 MT-ND1 TGGCCAACCTCCTACTCCTC]

['ACTAGTCTCAGGCTTCAACATCGAAYACGCC

1251 m.3949T>C 4535 MT-ND1 GCAGGCCCCTTCGCCCTATT']

NM_003140.2(SRY):c.326T>C ['CTTACTGAAGCCGAAAAATGGCCATYCTTCC

1252 (p.Phel09Ser) 6736 SRY AGGAGGCACAGAAATTACAG]

NM_003140.2(SRY):c.203T>C ['GTGAAGCGACCCATGAACGCATTCAYCGTG

1253 (p.Ile68Thr) 6736 SRY TGGTCTCGCGATCAGAGGCGC]

NM_021083.2(XK):c.880T>C ['ACTCTATACTGGTATCAACATGTTCNGCTGG

1254 (p.Cys294Arg) 7504 XK TCTGCTGTACAGCTGAAAAT']

NM_000354.5 (SERPINA7) : c.74 ['CACCAGATGGAACAATACTATCACCYAGTG

1255 0T>C (p.Leu247Pro) 6906 SERPINA7 GATATGGAATTGAACTGCACA']

M_000044.3 (AR) : c.2033 T>C ['TGTCAGCCCATCTTTCTGAATGTCCYGGAAG

1256 (p.Leu678Pro) 367 AR CCATTGAGCCAGGTGTAGTG]

M_000044.3 (AR) : c.2423 T>C ['ATCACCCCCCAGGAATTCCTGTGCAYGAAA

1257 (p.Met808Thr) 367 AR GCACTGCTACTCTTCAGCATT']

M_000044.3(AR):c.2596T>C ['CTACCAGCTCACCAAGCTCCTGGACYCCGTG

1258 (p.Ser866Pro) 367 AR CAGCCTGTAAGCAAACGATG]

NM_000451.3 (SHOX) :c .877T>C ['GAAGCACGCGGAGGCCCTGGGGCTCYGACC

1259 (p.Ter293Arg) 6473 SHOX CGCCGCGCAGCCCCCCGCGCG]

1260 NM_000330.3(RSl):c.286T>C -1 - ['TTGAGCCGGGCCTTGTTTGCAGTCCRCGAAG (p.Trp96Arg) AATACCAGCCCACATACTGC]

NM_000330.3(RSl):c.38T>C ['ATAGAAGGCTTTTTGTTATTACTTCYCTTTG

1261 (p.Leul3Pro) 6247 RSI GCTATGAAGGTATGTGCTAT']

NM_000330.3(RSl):c.667T>C ['CCGAGCTGAGGCAGGCATCAGGCACRCTTG

1262 (p.Cys223Arg) -1 - CTGACGCACTCCAGCAGCTCC]

NM_002764.3 (PRP S 1 ) :c .344T> ['ATCTCAGCCAAGCTTGTTGCAAATAYGCTAT

1263 C (p.Metl l5Thr) 5631 PRPS1 CTGTAGCAGGTGCAGATCAT']

NM_002764.3(PRPSl):c.455T> ['AATTTGTATGCAGAGCCGGCTGTCCYAAAGT

1264 C (p.Leul52Pro) 5631 PRPS1 GGATAAGGGAGAATATCTCT']

NM_002764.3 (PRP S 1 ) :c .869T> ['TTTCCTTTCTTGCCTTTCTAGGTGAYTGACAT

1265 C (p.Ile290Thr) 5631 PRPS1 CTCTATGATCCTTGCAGAA']

NM_000291.3(PGKl):c.263T>C ['CCAGTTGCTGTAGAACTCAAATCTCYGCTGG

1266 (p.Leu88Pro) 5230 PGK1 GCAAGTAAGTGCCAGGCTCT']

NM_000291.3(PGKl):c.946T>C ['CACCTCTACCCCTCAGGGCTTGGACYGTGGT

1267 (p.Cys316Arg) 5230 PGK1 CCTGAAAGCAGCAAGAAGTA']

NM_000291.3(PGKl):c.758T>C ['CATCATTTTGGCTCCCCTGTGTAGAYTGGCA

1268 (p.Ile253Thr) 5230 PGK1 CTTCTCTGTTTGATGAAGAG]

NM_001122606.1 (L AMP2) :c .96 ['CATTGCAAATAACAATCTCAGCTACYGGGA

1269 1T>C (p.Trp321Arg) 3920 LAMP2 TGCCCCCCTGGGAAGTTCTTA']

NM_000206.2(IL2RG) : c.343 T> ['ATTCTCTGAAGAAATCACTTCTGGCYGTCAG

1270 C (p.Cysl l5Arg) 3561 IL2RG TTGCAAAAAAAGGAGATCCA']

NM_000206.2(IL2RG):c.452T> ['ACACAGATGCTAAAACTGCAGAATCYGGGT

1271 C (p.Leul51Pro) 3561 IL2RG AATTTGGAAAGAAAGGGTCAA']

NM_000194.2(HPRT 1 ) : c.122T> ['GAAAGGGTGTTTATTCCTCATGGACYAATTA

1272 C (p.Leu41Pro) 3251 HPRT1 TGGACAGGTAAGTAAGATCT']

NM_000194.2(HPRT 1 ) : c.170T> ['CTTGCTCGAGATGTGATGAAGGAGAYGGGA

1273 C (p.Met57Thr) 3251 HPRT1 GGCCATCACATTGTAGCCCTC]

NM_000132.3(F8):c.6554T>C ['ATTCGCAGCACTCTTCGCATGGAGTYGATGG

1274 (p.Leu2185Ser) 2157 F8 GCTGTGATTTAAATAGTAAG']

NM_000132.3(F8):c.985T>C ['GGACCTTGGACAGTTTCTACTGTTTYGTCAT

1275 (p.Cys329Arg) 2157 F8 ATCTCTTCCCACCAACATGG]

NM_000132.3(F8):c.5372T>C ['AGAGCAGAAGTTGAAGATAATATCAYGGTG

1276 (p.Metl791Thr) 2157 F8 AGTTAAGGACAGTGGAATTAC]

NM_000132.3(F8):c.l754T>C ['CCTTTCAATATATGTAATTAACAGAYAATGT

1277 (p.Ile585Thr) 2157 F8 CAGACAAGAGGAATGTCATC]

NM_000132.3(F8):c.935T>C ['TCCTTGGAAATCTCGCCAATAACTTYCCTTA

1278 (p.Phe312Ser) 2157 F8 CTGCTCAAACACTCTTGATG]

NM_000132.3(F8):c.980T>C ['TTGATGGACCTTGGACAGTTTCTACYGTTTT

1279 (p.Leu327Pro) 2157 F8 GTCATATCTCTTCCCACCAA']

NM_000132.3(F8):c.l l74T>C ['CTCTCCTTCCTTTATCCAAATTCGCYCAGTTG

1280 (p.Ser392Pro) 2157 F8 CCAAGAAGCATCCTAAAAC]

NM_000132.3(F8):c.l417T>C ['ATCAGGAATCTTGGGACCTTTACTTYATGGG

1281 (p.Tyr473His) 2157 F8 GAAGTTGGAGACACACTGTT']

1282 NM_000132.3(F8):c.l481T>C 2157 F8 ['AATCAAGCAAGCAGACCATATAACAYCTAC (p.Ile494Thr) CCTCACGGAATCACTGATGTC]

NM_000132.3(F8):c.l729T>C ['CCCTCTCCTCATCTGCTACAAAGAAYCTGTA

1283 (p.Ser577Pro) 2157 F8 GATCAAAGAGGAAACCAGGT']

NM_000132.3(F8):c.l958T>C ['CAGTTGTCAGTTTGTTTGCATGAGGYGGCAT

1284 (p.Val653Ala) 2157 F8 ACTGGTACATTCTAAGCATT']

['TTCTGTCTTCTTCTCTGGATATACCYTCAAAC

1285 NM_000132.3(F8):c.2029T>C 2157 F8 ACAAAATGGTCTATGAAGA']

['GTTTCTTTACTTGGGCAAAGGACAGYGGGCC

1286 NM_000132.3(F8):c.6193T>C 2157 F8 CCAAAGCTGGCCAGACTTCA']

NM_007325.4(GRIA3):c.2117T> ['GTGTACGAGAAAATGTGGTCTTACAYGAAA

1287 C (p.Met706Thr) 2892 GRIA3 TCAGCGGAGCCATCTGTGTTT']

NM_000402.4(G6PD):c.1058T> ['GAGGGCGAGGCCACCAAAGGGTACCYGGAC

1288 C (p.Leu353Pro) 2539 G6PD GACCCCACGGTGCCCCGCGGG]

NM_000402.4(G6PD):c.1054T> ['TGGAGAGGGCGAGGCCACCAAAGGGYACCT

1289 C (p.Tyr352His) 2539 G6PD GGACGACCCCACGGTGCCCCG]

NM_001097642.2(GJBl):c.397T ['GGTCCACATCTCAGGGACACTGTGGYGGAC

1290 >C (p.Trpl33Arg) 2705 GJB1 CTATGTCATCAGCGTGGTGTT']

NM_000166.5 (GJB 1 ) :c .407T>C ['TCAGGGACACTGTGGTGGACCTATGYCATC

1291 (p.Vall36Ala) 2705 GJB1 AGCGTGGTGTTCCGGCTGTTG]

NM_000032.4(ALAS2):c.595T> ['TGTGTCCGTCTGGTGTAGTAATGATYACCTG

1292 C (p.Tyrl99His) 212 ALAS2 GGCATGAGCCGACACCCTCA']

NM_020061.5(OPNlLW):c.607 ['CTGGCCCCACGGCCTGAAGACTTCAYGCGG

1293 T>C (p.Cys203Arg) 5956 0PN1LW CCCAGACGTGTTCAGCGGCAG]

NM_000513.2(OPNlMW):c.607 ['CTGGCCCCACGGCCTGAAGACTTCAYGCGG

1294 T>C (p.Cys203Arg) 2652 OPN1MW CCCAGACGTGTTCAGCGGCAG]

NM_000513.2(OPNlMW):c.529 ['GGCCATCGTGGGCATTGCCTTCTCCYGGATC

1295 T>C (p.Trpl77Arg) 2652 OPN1MW TGGGCTGCTGTGTGGACAGC]

NM_000273.2(GPR143):c.397T> ['GCTGTTGTACAGTGCCTGCTTCTGGHGGCTG

1296 C (p.Trpl33Arg) 4935 GPR143 TTTTGCTATGCAGTGGATGC]

NM_000133.3(F9):c.52T>C ['AGAATCACCAGGCCTCATCACCATCYGCCTT

1297 (p.CyslSArg) 2158 F9 TTAGGATATCTACTCAGTGC]

NM_000133.3(F9):c.l058T>C ['TTCCTCAAATTTGGATCTGGCTATGYAAGTG

1298 (p.Val353Ala) 2158 F9 GCTGGGGAAGAGTCTTCCAC]

NM_000133.3(F9):c.l l44T>C ['AGTTCCACTTGTTGACCGAGCCACAHGTCTT

1299 (p.Cys382Arg) 2158 F9 CGATCTACAAAGTTCACCAT']

NM_000133.3(F9):c.l328T>C ['TGTGCAATGAAAGGCAAATATGGAAYATAT

1300 (p.Ile443Thr) 2158 F9 ACCAAGGTATCCCGGTATGTC]

NM_000133.3(F9):c.l357T>C ['TACCAAGGTATCCCGGTATGTCAACYGGATT

1301 (p.Trp453Arg) 2158 F9 AAGGAAAAAACAAAGCTCAC]

NM_000133.3(F9):c.82T>C ['TTTAGGATATCTACTCAGTGCTGAAYGTACA

1302 (p.Cys28Arg) 2158 F9 GGTTTGTTTCCTTTTTTAAA']

['CTGAATTTTGGAAGCAGTATGTTGGYAAGC

1303 NM_000133.3(F9):c.277+2T>C 2158 F9 AATTCATTTTATCCTCTAGCT']

1304 NM_000133.3(F9):c.l031T>C 2158 F9 ['ATTGCTGACAAGGAATACACGAACAYCTTC (p.Ile344Thr) CTCAAATTTGGATCTGGCTAT']

NM_000169.2(GLA):c.484T>C ['CATTGATGCCCAGACCTTTGCTGACYGGGGA

1305 (p.Trpl62Arg) -1 - GTAGATCTGCTAAAATTTGA']

NM_000169.2(GLA):c.806T>C ['TTATTTCATTCTTTTTCTCAGTTAGYGATTGG

1306 (p.Val269Ala) -1 - CAACTTTGGCCTCAGCTGG]

NM_015107.2(PHF8):c.836T>C ['CCAACAAATGCCAATCTGACTCTCTYTGAGT

1307 (p.Phe279Ser) 23133 PHF8 GCTGGAGCAGTTCCTCTAAT']

NM_033290.3(MIDl):c.l877T> ['TATGATGCTTTGAACTCCATCCACCYCTACA

1308 C (p.Leu626Pro) 4281 MIDI CCTTCGACGTCGCATTTGCG]

NM_033290.3(MIDl):c.884T>C ['TTCAAGGTGATGAGGCTTCGCAAACYGGCT

1309 (p.Leu295Pro) 4281 MIDI CAGCAGATTGCAAACTGCAAA']

M_000444.5 (PHEX) : c.755T>C ['CAGTATCGGGATGCCCTTTACAAGTYCATGG

1310 (p.Phe252Ser) 5251 PHEX TGGATACTGCCGTGCTTTTA']

M_000444.5 (PHEX) : c.1664T> ['CTCATAGGATTTCCAGCAGGAGAGCYCCAG

1311 C (p.Leu555Pro) 5251 PHEX AAGCCTTTCTTTTGGGGAACA]

NM_001205019.1(GK):c. l525T> ['AGAAAGTGAAATTCGTTATTCTACAYGGAA

1312 C (p.Trp509Arg) 2710 GK GAAAGCTGTGATGAAGTCAAT']

NM_000475.4(NR0Bl):c.890T> ['AACTGCTGGGCGTCCCTGCTCATGCYTGAGC

1313 C (p.Leu297Pro) 190 NR0B1 TGGCCCAGGACCGCTTGCAG]

NM_000531.5 (OTC) : c.332T>C ['CTTCTGGGAGGACATCCTTGTTTTCYTACCA

1314 (p.Leull lPro) 5009 OTC CACAAGATATTCATTTGGGT']

NM_000531.5 (OTC) : c.134T>C ['CTGAAGGGCCGTGACCTTCTCACTCYAAAA

1315 (p.Leu45Pro) 5009 OTC AACTTTACCGGAGAAGAAATT']

NM_000531.5 (OTC) : c.717+2T> ['TTGGCAGAGCAGTATGCCAAAGAGGYATGC

1316 C 5009 OTC TCTTTACATGTAAAGCTATTA]

NM_001399.4(EDA):c.l81T>C ['CCTCCACCTGCTGACGTTGTGCTGCYACCTA

1317 (p.Tyr61His) 1896 EDA GAGTTGCGCTCGGAGTTGCG]

NM_001015877.1 (PHF6) : c.2T> ['CATTCTAAAGGCAATTTAAAAATCAYGTCA

1318 C (p.MetlThr) 84295 PHF6 AGCTCAGTTGAACAGAAAAAA']

NM_001128834.2(PLPl):c.487T ['CATCACCTATGCCCTGACCGTTGTGYGGCTC

1319 >C (p.Trpl63Arg) 5354 PLP1 CTGGTGTTTGCCTGCTCTGC]

NM_001128834.2(PLPl):c.671T ['CCTGGCAAGGTTTGTGGCTCCAACCYTCTGT

1320 >C (p.Leu224Pro) 5354 PLP1 CCATCTGCAAAACAGCTGAG]

NM_001128834.2(PLPl):c.560T ['AACACCTGGACCACCTGCCAGTCTAYTGCCT

1321 >C (p.Ilel87Thr) 5354 PLP1 TCCCCAGCAAGACCTCTGCC]

NM_001128834.2(PLPl):c.710T ['ATTTTCCTGCAGTTCCAAATGACCTYCCACC

1322 >C (p.Phe237Ser) 5354 PLP1 TGTTTATTGCTGCATTTGTG]

NM_000116.4(TAZ):c.352T>C ['CTCCCACTTCTTCAGCTTGGGCAAGYGTGTG

1323 (p.Cysl l8Arg) 6901 TAZ CCTGTGTGCCGAGGTGAGCT']

NM_000377.2(WAS):c.244T>C ['CTTCGTGAAGGATAACCCCCAGAAGYCCTA

1324 (p.Ser82Pro) 7454 WAS CTTCATCCGCCTTTACGGCCT']

NM_000377.2(WAS):c.809T>C ['AACCTCGACCCAGATCTGCGGAGTCYGTTCT

1325 (p.Leu270Pro) 7454 WAS CCAGGGCAGGAATCAGCGAG]

1326 NM_182680.1(AMELX):c.2T>C -1 - ['CTTACATTTCAGAACCATCAAGAAAYGGGG (p.MetlThr) ACCTGGATTTTATTTGCCTGC]

NM_000074.2(CD40LG) : c.464T ['ACCATGAGCAACAACTTGGTAACCCYGGAA

1327 >C (p.Leul55Pro) 959 CD40LG AATGGGAAACAGCTGACCGTT']

NM_139058.2(ARX):c.98T>C 17030 ['TCCTCCTACTGCATCGACAGCATCCYGGGCC

1328 (p.Leu33Pro) 2 ARX GGAGGAGCCCGTGCAAAATG]

NM_001109878.1(TBX22):c.641 ['TGATCATTTCTCCTCCAGATCATTCYGCAAT

1329 T>C (p.Leu214Pro) 50945 TBX22 CCATGCATAAGTACAAACCC]

NM_000061.2(BTK):c.2T>C ['GGTGAACTCCAGAAAGAAGAAGCTAYGGCC

1330 (p.MetlThr) 695 BTK GCAGTGATTCTGGAGAGCATC]

NM_000061.2(BTK):c. l223T>C ['AAGGACCTGACCTTCTTGAAGGAGCYGGGG

1331 (p.Leu408Pro) 695 BTK ACTGGACAATTTGGGGTAGTG]

NM_000061.2(BTK):c. l516T>C ['GCTGCTAGAGATGTGCAAGGATGTCYGTGA

1332 (p.Cys506Arg) 695 BTK AGCCATGGAATACCTGGAGTC]

NM_000061.2(BTK):c. l625T>C ['GTTGTTAAAGTATCTGATTTCGGCCYGTCCA

1333 (p.Leu542Pro) 695 BTK GGTGAGTGTGGCTTTTTCAT']

NM_000061.2(BTK):c. l741T>C ['CAAGTTCAGCAGCAAATCTGACATTYGGGC

1334 (p.Trp581Arg) 695 BTK TTTTGGTAAGTGGATAAGATT']

NM_000061.2(BTK):c. l955T>C ['TTCAAAATTCTTCTGAGCAATATTCYAGATG

1335 (p.Leu652Pro) 695 BTK TCATGGATGAAGAATCCTGA']

NM_015884.3(MBTPS2):c.l424 ['GATGGACAATGGATTCTAAACTCTTYCTTGG

1336 T>C (p.Phe475Ser) 51360 MBTPS2 ATGCCACCCTTACCTCAGTG]

NM_014009.3 (FOXP3 ) : c.970T> ['GATTCATCCCCACCCTCTGACAGAGYTCCTC

1337 C (p.Phe324Leu) 50943 FOXP3 CACAACATGGACTACTTCAA']

NM_014009.3(FOXP3):c.l099T ['GACACTCAATGAGATCTACCACTGGYTCAC

1338 >C (p.Phe367Leu) 50943 FOXP3 ACGCATGTTTGCCTTCTTCAG]

NM_022567.2(NYX):c.302T>C ['CTGCGCCACAACAACCTGTCCTTCAYCACGC

1339 (p.IlelOlThr) 60506 NYX CCGGCGCCTTCAAGGGCCTG]

NM_003639.4(IKBKG):c.l249T ['CACCCTGCAGATACATGTCATGGAGYGCATT

1340 >C (p.Cys417Arg) 8517 KBKG GAGTAGGGCCGGCCAGTGCA']

NM_006579.2(EBP):c.53T>C ['CCATACTGGCCTCAGCACCTAAGACYGGAC

1341 (p.Leul8Pro) 10682 EBP AACTTTGTACCTAATGACCGC]

NM_003159.2(CDKL5):c.215T> ['CTTCGGACTCTCAAGCAGGAAAACAHTGTG

1342 C (p.Ile72Thr) 6792 CDKL5 GAGTTGAAGGAAGCATTTCGT']

NM_001011658.3(TRAPPC2):c. ['GCCTTAATTATTTCACATATGAGGTYTATTA

1343 248T>C (p.Phe83Ser) -1 - TGCTTCATGACATAAGACAA']

NM_001011658.3(TRAPPC2):c. ['AGTTACCTTTACTAAGAAGGTAAGGRTATGC

1344 238+4T>C -1 - CCCGCAGTGACAAATGCCGA']

NM_003688.3(CASK):c.802T>C ['GGATCCAGCTGAAAGGATCACTGTTYATGA

1345 (p.Tyr268His) 8573 CASK AGCACTGAATCACCCATGGCT']

NM_003688.3(CASK):c.2740T> ['TGAGCTCGTGTGCACAGCCCCACAGYGGGT

1346 C (p.Trp914Arg) 8573 CASK CCCTGTCTCCTGGGTCTATTA']

NM_001159702.2(FHLl):c.457T ['AGGGGAGGACTTCTACTGCGTGACTYGCCA

1347 >C (p.Cysl53Arg) 2273 FHL1 TGAGACCAAGTTTGCCAAGCA']

1348 NM_001159702.2(FHLl):c.310T 2273 FHL1 ['GGAGGACTCCCCCAAGTGCAAGGGGYGCTT >C (p.Cysl04Arg) CAAGGCCATTGTGGCAGGTAC]

NM_001159702.2(FHLl):c.625T ['CACCGCTGTGGAGGACCAGTATTACYGCGT

1349 >C (p.Cys209Arg) 2273 FHL1 GGATTGCTACAAGAACTTTGT']

NM_001363.4(DKCl):c. ll3T>C ['ATACAACACGCTGAAGAATTTCTTANCAAA

1350 (p.Ile38Thr) 1736 DKC1 CCTGAATCCAAAGTTGCTAAG]

NM_178152.2(DCX):c.373T>C ['CTTATTTCTTGCCTTAGGGGAAAGCYATGTC

1351 (p.Tyrl25His) 1641 DCX TGTTCCTCAGACAACTTCTT']

NM_005183.3(CACNAlF):c.226 ['ATCCTGTTGAACGTGTTTCTTGCCAYTGCTG

1352 7T>C (p.Ile756Thr) 778 CACNA1F TGGACAACCTGGCCAGTGGA']

NM_001493.2(GDIl):c.275T>C ['ACAGGGCAGCTGGTAAAGATGCTACYGTAT

1353 (p.Leu92Pro) 2664 GDI1 ACAGAGGTGACTCGCTACCTG]

NM_006517.4(SLC16A2):c. l313 ['ATCATGGCCCCCATTGCATTTGAGCYGGTGG

1354 T>C (p.Leu438Pro) 6567 SLC16A2 GCCCAATGCAGGCCTCACAG]

NM_006517.4(SLC16A2):c.1190 ['CTCCAGGTCCTTTCCTTCCTGCTCCYGGGCC

1355 T>C (p.Leu397Pro) 6567 SLC16A2 TGATGTCCATGATGATTCCC]

NM_006517.4(SLC16A2):c. l481 ['CCCCCCATCATCGGGGCTGTAATCCYCTTCT

1356 T>C (p.Leu494Pro) 6567 SLC16A2 TCGTCCCTCTGATGCATCAA']

NM_004586.2(RPS6KA3):c.803 ['GAAATGCTTACTGGTACACTCCCTTYCCAAG

1357 T>C (p.Phe268Ser) 6197 RPS6KA3 GAAAAGATCGAAAAGAAACA']

NM_000489.4(ATRX):c.4840T> ['AAGTTTTCTTCATACAGTTCTTTTGYGTGAC

1358 C (p.Cysl614Arg) 546 ATRX AAACTGGATTTCAGCACGGC]

NM_000489.4(ATRX):c.6250T> ['GAAGTGGCTTCGAAACATTGACTATYACCGT

1359 C (p.Tyr2084His) 546 ATRX TTAGATGGTTCCACTACTGC]

NM_000489.4(ATRX):c.1226T> ['GATATTAAGAAGGCTCATCTTGCATYGGAA

1360 C (p.Leu409Ser) 546 ATRX GAAGACTTAAATTCCGAGTTT']

NM_000489.4(ATRX):c.6149T> ['CAGTCCCTCATATCTCTGGACTTGAYTGAAG

1361 C (p.Ile2050Thr) 546 ATRX ATTTTCTTGAATTAGCTAGT']

NM_001110556.1(FLNA):c.720

+2T>C 2316 FLNA

NM_001127899.3(CLCN5):c.17 ['AGGTGGGGTGACTCGGATGACTGTTYCTCTT

1362 68T>C (p.Ser590Pro) 1184 CLCN5 GTTGTCATAATGTTTGAACT']

NM_004992.3(MECP2):c.464T> ['GACACATCCCTGGACCCTAATGATTBTGACT

1363 C (p.Phel55Ser) 4204 MECP2 TCACGGTAACTGGGAGAGGG]

NM_001061.4(TBXASl):c.l463 ['TGCCTCGGGGTGCGTCTAGGGCTGCYTGAG

1364 T>C (p.Leu488Pro) 6916 TBXAS1 GTCAAGTTGACACTGCTCCAC]

NM_001061.4(TBXASl):c.248T ['TTTTTTATTCCTCCCAGGTACTATCYTGGTCG

1365 >C (p.Leu83Pro) 6916 TBXAS1 TCGGATGTTTATTGTTATT']

NM_000128.3(Fll):c.901T>C ['TTCTTCATTTTACCATGACACTGATYTCTTGG

1366 (p.Phe301Leu) 2160 Fl l GAGAAGAACTGGATATTGT']

NM_000128.3(Fll):c.l66T>C ['GGTAGTCTGCACTTACCACCCAAGAYGTTTA

1367 (p.Cys56Arg) 2160 Fl l CTCTTCACTTTCACGGCGGA]

NM_000203.4(IDUA):c.l469T> ['AGCCCCGACGGCGAGTGGCGGCGCCYGGGC

1368 C (p.Leu490Pro) 3425 IDUA CGGCCCGTCTTCCCCACGGCA']

1369 NM_000431.3(MVK):c.803T>C 4598 MVK ['ATCGTGGCCCCCCTCCTGACCTCAAYAGATG (p.Ile268Thr) CCATCTCCCTGGAGTGTGAG']

NM_014425.3(INVS):c.l478T> ['TTATGCTTATAGGGAAGAACAGCTTYGCATT

1370 C (p.Leu493Ser) 27130 INVS GGTCCTGCAACAATGGATAC]

NM_000108.4(DLD):c.1178T>C ['GACTACAATTGTGTGCCATCAGTGAYTTACA

1371 (p.Ile393Thr) 1738 DLD CACACCCTGAAGTTGCTTGG']

NM_000170.2(GLDC):c.2T>C ['GGGCAGGGGACGGTGGCCGCGGCCAYGCAG

1372 (p.MetlThr) 2731 GLDC TCCTGTGCCAGGGCGTGGGGG]

NM_000151.3(G6PC):c.229T>C ['AGACTGGCTCAACCTCGTCTTTAAGYGGTAA

1373 (p.Trp77Arg) 2538 G6PC GAACCATATAGAGAGGAGAT']

M_004453.3(ETFDH):c.2T>C ['CCGAGAGTCCTGGTGACTTTGAACAYGCTG

1374 (p.MetlThr) 2110 ETFDH GTGCCGCTAGCCAAGCTGTCC]

NM_000136.2(FANCC):c.l661T ['CTGGCCCGAGAGCTCCTTAAAGAGCYGCGA

1375 >C (p.Leu554Pro) -1 - ACTCAAGTCTAGAAGGCACGC]

NM_000131.4(F7):c.38T>C ['GCCCTCAGGCTCCTCTGCCTTCTGCYTGGGC

1376 (p.Leul3Pro) 2155 F7 TTCAGGGCTGCCTGGCTGCA']

NM_000131.4(F7):c.983T>C ['CCCCTCTGCCTGCCCGAACGGACGTYCTCTG

1377 (p.Phe328Ser) 2155 F7 AGAGGACGCTGGCCTTCGTG]

NM_024649.4(BBSl):c.l553T> ['ACAACCCGTCCTGTCCTGGGGCTGCYGGTCT

1378 C (p.Leu518Pro) -1 - GCTTCCTGTACAACGAGGCG]

NM_000490.4(AVP):c.200T>C ['TGCGCGGACGAGCTGGGCTGCTTCGYGGGC

1379 (p.Val67Ala) 551 AVP ACGGCTGAGGCGCTGCGCTGC]

NM_000490.4(AVP):c.61T>C ['CCTACTGGCCTTCTCCTCCGCGTGCYACTTC

1380 (p.Tyr21His) 551 AVP CAGAACTGCCCGAGGGGCGG]

NM_001692.3(ATP6VlBl):c24 ['GGGACTCAGAGGAGCGGGCAGGTGCYTGAG

1381 2T>C (p.Leu81Pro) 525 ATP6V1B1 GTGGCTGGCACCAAGGCGATT']

NM_003361.3(UMOD):c.649T> ['GGGCGGTGCGCGCATGGCCGAGACCBGCGT

1382 C (p.Cys217Arg) 7369 UMOD GCCAGTCCTGCGCTGCAACAC]

NM_003361.3 (UMOD) :c .376T> ['TAGCCACTGCCACGCCCTGGCCACAYGTGTC

1383 C (p.Cysl26Arg) 7369 UMOD AATGTGGTGGGCAGCTACTT']

NM_003361.3(UMOD):c.943T> ['CAAATCGAATAATGGCAGATGGCACYGCCA

1384 C (p.Cys315Arg) 7369 UMOD GTGCAAACAGGACTTCAACAT']

NM_080911.2(UNG):c.752T>C ['AATCAGAACTCGAATGGCCTTGTTTYCTTGC

1385 (p.Phe251Ser) 7374 UNG TCTGGGGCTCTTATGCTCAG]

NM_199292.2(TH):c.707T>C ['CAGGTGTACCGCCAGCGCAGGAAGCYGATT

1386 (p.Leu236Pro) 7054 TH GCTGAGATCGCCTTCCAGTAC]

NM_001065.3 (TNFRSF1 A) : c.17 TNFRSF1 ['CCACCCTCAAAATAATTCGATTTGCYGTACC

1387 5T>C (p.Cys59Arg) 7132 A AAGTGCCACAAAGGTAGGGG]

NM_001065.3(TNFRSFlA):c.34 TNFRSF1 ['AATGGGTCAGGTGGAGATCTCTTCTYGCACA

1388 9T>C (p.Cysl l7Arg) 7132 A GTGGACCGGGACACCGTGTG]

NM_000546.5(TP53):c.755T>C ['GGCGGCATGAACCGGAGGCCCATCCYCACC

1389 (p.Leu252Pro) 7157 TP53 ATCATCACACTGGAAGACTCC]

NM_000546.5(TP53):c.398T>C ['CAGTACTCCCCTGCCCTCAACAAGAYGTTTT

1390 (p.Metl33Thr) 7157 TP53 GCCAACTGGCCAAGACCTGC]

1391 NM_000546.5(TP53):c.l031T>C 7157 TP53 ['GAGCGCTTCGAGATGTTCCGAGAGCYGAAT (p.Leu344Pro) GAGGCCTTGGAACTCAAGGAT']

NM_001018005.1(TPMl):c.284 ['TCTCTGAACAGACGCATCCAGCTGGYTGAG

1392 T>C (p.Val95Ala) 7168 TPM1 GAAGAGTTGGATCGTGCCCAG]

NM_001159287.1(TPIl):c.832T ['GGGTGGTGCTTCCCTCAAGCCCGAAYTCGTG

1393 >C (p.Phe278Leu) 7167 TPI1 GACATCATCAATGCCAAACA']

NM_003242.5(TGFBR2):c.923T ['AAGCATGAGAACATACTCCAGTTCCYGACG

1394 >C (p.Leu308Pro) 7048 TGFBR2 GCTGAGGAGCGGAAGACGGAG]

NM_000660.5(TGFBl):c.673T> ['CTTTCGCCTTAGCGCCCACTGCTCCYGTGAC

1395 C (p.Cys225Arg) 7040 TGFB1 AGCAGGGATAACACACTGCA']

NM_000660.5(TGFBl):c.241T> ['GCTGCCCGAGGCCGTGCTCGCCCTGYACAA

1396 C (p.Tyr81His) 7040 TGFB1 CAGCACCCGCGACCGGGTGGC]

NM_000660.5 (TGFB 1 ) :c .667T> ['TGAGGGCTTTCGCCTTAGCGCCCACNGCTCC

1397 C (p.Cys223Arg) 7040 TGFB1 TGTGACAGCAGGGATAACAC]

NM_001128177.1(THRB):c.929 ['ATCATCCTCCTCAAAGGCTGCTGCAYGGAG

1398 T>C (p.Met310Thr) 7068 THRB ATCATGTCCCTTCGCGCTGCT']

NM_001128177.1(THRB):c. l33 ['CCGCTTCCTGCACATGAAGGTGGAAYGCCC

1399 6T>C (p.Cys446Arg) 7068 THRB CACAGAACTCTTCCCCCCTTT']

NM_001128177.1(THRB):c. l37 ['CTCTTCCCCCCTTTGTTCTTGGAAGYGTTCG

1400 3T>C (p.Val458Ala) 7068 THRB AGGATTAGACTGACTGGATT']

NM_007313.2(ABLl):c.814T>C ['GAAGCACAAGCTGGGCGGGGGCCAGYACGG

1401 (p.Tyr272His) 25 ABLl GGAGGTGTACGAGGGCGTGTG]

NM_007313.2(ABLl):c.988T>C ['AGGGGTCTGCACCCGGGAGCCCCCGYTCTA

1402 (p.Phe330Leu) 25 ABLl TATCATCACTGAGTTCATGAC]

NM_007313.2(ABLl):c.l l09T> ['ATGGCCACTCAGATCTCGTCAGCCAYGGAG

1403 C (p.Met370Thr) 25 ABLl TACCTGGAGAAGAAAAACTTC]

NM_021961.5(TEADl):c.l261T ['TGAACACGGAGCACAACATCATATTYACAG

1404 >C (p.Tyr?His) 7003 TEAD1 GCTTGTAAAGGACTGAACATG]

NM_001256850.1(TTN):c.2926T ['TGGATACCCATCCCCGACAGTGACAHGGTA

1405 >C (p.Trp976Arg) 7273 TTN CAGGGAAGACTACCAAATCGA']

NM_133378.4(TTN):c.l00163T> ['GAAAACACAGATGACCTGACAACCCYGATC

1406 C (p.Leu33388Pro) -1 - ATCATGGACGTACAGAAACAA']

NM_003235.4(TG):c.3733T>C ['CCCCACAGGCTCTGCCATGCAGCAGYGCCA

1407 (p.Cysl245Arg) 7038 TG ATTGCTGTGCCGCCAGGGCTC]

NM_003235.4(TG):c.3229T>C ['TCTCTCTCCCACAGGCCCGACAACCYGCGAG

1408 (p.Cysl077Arg) 7038 TG AAATCTCGAACCAGTGGGCT']

NM_000733.3(CD3E):c.520+2T ['CGGGTGCTGGCGGCAGGCAAAGGGGYAAGG

1409 >C 916 CD3E CTGTGGAGTCCAGTCAGAGGA]

NM_003000.2(SDHB):c.487T>C ['GCCTTATTTGAAGAAGAAGGATGAAYCTCA

1410 (p.Serl63Pro) 6390 SDHB GGAAGGCAAGCAGCAGTATCT']

NM_003106.3 (SOX2) : c.290T>C ['CCGTTCATCGACGAGGCTAAGCGGCYGCGA

1411 (p.Leu97Pro) -1 - GCGCTGCACATGAAGGAGCAC]

NM_001024858.2(SPTB):c.604T ['TAATGTCACCAACTTTACCTCCAGCYGGAAG

1412 >C (p.Trp202Arg) 6710 SPTB GATGGCTTGGCCTTTAATGC]

1413 NM_001024858.2(SPTB):c.6055 6710 SPTB ['GGTGTGCCAGTTCTCGAGGGATGCCYCTGTG T>C (p.Ser2019Pro) GCTGAGGCGTGGCTGATTGC]

NM_003126.2(SPTAl):c.779T> ['TTGGCTCTCCAGAGACAGAAAGCTCBGTCCA

1414 C (p.Leu260Pro) 6708 SPTA1 ATGCTGCAAACTTACAACGA']

NM_003126.2(SPTAl):c.781T> ['GGCTCTCCAGAGACAGAAAGCTCTGYCCAA

1415 C (p.Ser261Pro) 6708 SPTA1 TGCTGCAAACTTACAACGATT']

NM_003126.2(SPTAl):c.620T> ['AAATTTGAAGACTTCCAAGTGGAGCYGGTA

1416 C (p.Leu207Pro) 6708 SPTA1 GCTAAAGAAGGGAGAGTTGTT']

NM_005633.3(SOSl):c.l294T> ['CGAGATTCAGAAGAATATTGATGGTYGGGA

1417 C (ρ.Τφ432Α¾) 6654 SOS1 GGGAAAAGACATTGGACAGTG]

NM_006920.4(SCNlA):c.3577T ['TGTGGAAGAAGGCAGAGGAAAACAAYGGT

1418 >C (p.Trpl l93Arg) -1 - GGAACCTGAGAAGGACGTGTTT']

NM_006920.4(SCNlA):c.4250T ['TTTGGGTATCTCTCTTTGCTTCAAGYTGTAA

1419 >C (p.Vall417Ala) -1 - GTGAACACTATTTTCTCTGA']

NM_006920.4(SCNlA):c.434T> ['ACTATTTTGACAAACTGTGTGTTTAHGACAA

1420 C (p.Metl45Thr) 6323 SCN1A TGAGTAACCCTCCTGATTGG']

NM_006920.4(SCNlA):c.4462T ['TCTATACTTTGGAGGTCAAGACATCYTTATG

1421 >C (p.Phel488Leu) -1 - ACAGAAGAACAGAAGAAATA']

NM_152296.4(ATPlA3):c.821T ['GGGCTGGAGGTGGGCAAGACGCCCAHCGCC

1422 >C (p.Ile274Thr) 478 ATP 1 A3 ATCGAGATTGAGCACTTCATC]

NM_152296.4(ATPlA3):c.2338 ['CAGCAATATCCCGGAGATCACGCCCYTCCTG

1423 T>C (p.Phe780Leu) 478 ATP 1 A3 CTGTTCATCATGGCCAACAT']

NM_000702.3(ATPlA2):c.2291 ['CCTCAGAATCTCCCCACAGGCCGCCYGATCT

1424 T>C (p.Leu764Pro) 477 ATP1A2 TTGACAACTTGAAGAAATCC]

NM_000702.3(ATPlA2):c.2659 ['ACGGCTACTGGGAATCCGCCTCGACYGGGA

1425 T>C (ρ.Τφ887Α¾) 477 ATP1A2 TGACCGGACCATGAATGATCT']

NM_000702.3 (ATP 1 A2) :c .2192 ['AAGAAGGCTGACATTGGCATTGCCAYGGGC

1426 T>C (p.Met731Thr) 477 ATP1A2 ATCTCTGGCTCTGACGTCTCT']

NM_000702.3(ATPlA2):c.857T ['GGGCGGACACCCATAGCAATGGAGAYTGAA

1427 >C (p.Ile286Thr) 477 ATP1A2 CACTTCATCCAGCTGATCACA']

NM_001035.2(RYR2):c. l298T> ['ATGTTTATGGTTTATTTTAGGGGCCYTGATG

1428 C (p.Leu433Pro) 6262 RYR2 CTCTCAGCAAGAAAGCGAAG]

NM_000540.2(RYRl):c.14693T ['GTGGGTGTCCGGGCTGGCGGAGGCAYTGGG

1429 >C (p.Ile4898Thr) 6261 RYR1 GACGAGATCGAGGACCCCGCG]

NM_000539.3(RHO):c.l33T>C ['GTTCTCCATGCTGGCCGCCTACATGYTTCTG

1430 (p.Phe45Leu) 6010 RHO CTGATCGTGCTGGGCTTCCC]

NM_000321.2(RBl):c. l960+2T> ['CTCTTTCACTGTTTTATAAAAAAGGYTAGTA

1431 C 5925 RBI GATGATTATTTTCAAGAGCA']

NM_000321.2(RBl):c.2134T>C ['TATGATGTGTTCCATGTATGGCATAYGCAAA

1432 (p.Cys712Arg) 5925 RBI GTGAAGAATATAGACCTTAA']

NM_000329.2(RPE65):c.l022T> ['AGATTTGAGTTTGTTTATAATTACTYATATTT

1433 C (p.Leu341Ser) 6121 RPE65 AGCCAATTTACGTGAGAAC]

NM_000322.4(PRPH2):c.554T> ['ATTCAGTGGATCAGCAATCGCTACCYGGACT

1434 C (p.Leul85Pro) 5961 PRPH2 TTTCCTCCAAAGAAGTCAAA']

1435 NM_000322.4(PRPH2):c.2T>C 5961 PRPH2 ['CAACCCGGACTACACTTGGCAAGCAYGGCG (p.MetlThr) CTACTGAAAGTCAAGTTTGAC]

NM_001098668.2(SFTPA2):c.59 72923 ['ACTGAGGGTCCCAGCCCTGGAGACTYCCGC

1436 3T>C (p.Phel98Ser) 8 SFTPA2 TACTCAGATGGGACCCCTGTA']

NM_003018.3(SFTPC):c.218T> ['TTTCCCCAGGTTCTGGAGATGAGCAHTGGGG

1437 C (p.Ile73Thr) 6440 SFTPC CGCCGGAAGCCCAGCAACGC]

NM_003018.3(SFTPC):c.581T> ['AGCACCCTGTGTGGCGAGGTGCCGCYCTACT

1438 C (p.Leul94Pro) 6440 SFTPC ACATCTAGGACGCCTCCGGT']

NM_000055.2(BCHE):c. l004T> ['CTCACTGACATGCCAGACATATTACYTGAAC

1439 C (p.Leu335Pro) 590 BCHE TTGGACAATTTAAAAAAACC]

NM_002739.3(PRKCG):c.355T> ['CCCCACCTTCTGCGACCACTGTGGCYCCCTC

1440 C (p.Serl l9Pro) 5582 PRKCG CTCTACGGGCTTGTGCACCA']

NM_002739.3(PRKCG):c.l927T ['ACAGTGTGGCCGCAGCGGCGAGAACYTTGA

1441 >C (p.Phe643Leu) 5582 PRKCG CAAGTTCTTCACGCGGGCGGC]

NM_000141.4(FGFR2) :c .1018T ['TGTAACTTTTGAGGACGCTGGGGAAYATAC

1442 >C (p.Tyr340His) 2263 FGFR2 GTGCTTGGCGGGTAATTCTAT']

NM_000141.4(FGFR2) :c .1024T ['TTTTGAGGACGCTGGGGAATATACGHGCTTG

1443 >C (p.Cys342Arg) 2263 FGFR2 GCGGGTAATTCTATTGGGAT']

NM_000141.4(FGFR2):c.868T> ['CAGTGATGCCCAGCCCCACATCCAGBGGAT

1444 C (p.Trp290Arg) 2263 FGFR2 CAAGCACGTGGAAAAGAACGG]

NM_000141.4(FGFR2):c.799T> ['CCAAGCCGGACTGCCGGCAAATGCCYCCAC

1445 C (p.Ser267Pro) 2263 FGFR2 AGTGGTCGGAGGAGACGTAGA']

NM_000506.3(F2):c.l l39T>C ['CCTGCTGCCCCTCCCAGGCAGGTGAYGCTTT

1446 (p.Met380Thr) 2147 F2 TCCGGAAGAGTCCCCAGGAG]

NM_000313.3(PROSl):c.l501T ['TTCATTATTTTAAATAGATAATGTABCCAGT

1447 >C (p.Ser501Pro) 5627 PR0S1 GCTGAGGGTTGGCATGTAAA]

NM_002834.3(PTPNll):c.854T> ['TGACCGTGGTCTCTTTTTCTTCTAGNTGATCA

1448 C (p.Phe285Ser) 5781 PTPN11 TACCAGGGTTGTCCTACAC]

NM_002755.3(MAP2Kl):c. l58T ['CAGCAGCGAAAGCGCCTTGAGGCCTYTCTT

1449 >C (p.Phe53Ser) 5604 MAP2K1 ACCCAGAAGCAGAAGGTGGGA']

NM_001042465.1(PSAP):c. l055 ['GCTTTTGACAAAATGTGCTCGAAGCYGCCG

1450 T>C (p.Leu352Pro) 5660 PSAP AAGTCCCTGTCGGAAGAGTGC]

NM_000207.2(INS):c.l43T>C ['TACCTAGTGTGCGGGGAACGAGGCTBCTTCT

1451 (p.Phe48Ser) -1 - ACACACCCAAGACCCGCCGG]

NM_000311.3(PRNP):c.593T>C ['ACCACAACCACCAAGGGGGAGAACTYCACC

1452 (p.Phel98Ser) 5621 PRNP GAGACCGACGTTAAGATGATG]

NM_000371.3(TTR):c.l49T>C ['GGCAGTCCTGCCATCAATGTGGCCGBGCATG

1453 (p.Va OAla) 7276 TTR TGTTCAGAAAGGCTGCTGAT']

NM_000371.3(TTR):c.224T>C ['AGGAAAACCAGTGAGTCTGGAGAGCYGCAT

1454 (p.Leu75Pro) 7276 TTR GGGCTCACAACTGAGGAGGAA']

NM_000371.3(TTR):c.88T>C ['CACCCAGGGCACCGGTGAATCCAAGYGTCC

1455 (p.Cys30Arg) 7276 TTR TCTGATGGTCAAAGTTCTAGA']

NM_000371.3(TTR):c.272T>C ['GAATTTGTAGAAGGGATATACAAAGYGGAA

1456 (p.Val91Ala) 7276 TTR ATAGACACCAAATCTTACTGG]

1457 NM_000371.3(TTR):c.400T>C 7276 TTR ['CACCATTGCCGCCCTGCTGAGCCCCYACTCC (p.Tyrl34His) TATTCCACCACGGCTGTCGT']

NM_000371.3(TTR):c.250T>C ['GCATGGGCTCACAACTGAGGAGGAAYTTGT

1458 (p.Phe84Leu) 7276 TTR AGAAGGGATATACAAAGTGGA]

NM_000371.3(TTR):c.l57T>C ['TGCCATCAATGTGGCCGTGCATGTGHTCAGA

1459 (p.Phe53Leu) 7276 TTR AAGGCTGCTGATGACACCTG]

NM_000371.3(TTR):c.95T>C ['GGCACCGGTGAATCCAAGTGTCCTCYGATG

1460 (p.Leu32Pro) 7276 TTR GTCAAAGTTCTAGATGCTGTC]

NM_000371.3(TTR):c.l91T>C ['GCTGCTGATGACACCTGGGAGCCATYTGCCT

1461 (p.Phe64Ser) 7276 TTR CTGGGTAAGTTGCCAAAGAA']

NM_000371.3(TTR):c.265T>C ['TGAGGAGGAATTTGTAGAAGGGATAYACAA

1462 (p.Tyr89His) 7276 TTR AGTGGAAATAGACACCAAATC]

NM_000217.2(KCNAl):c. l223T ['ATTGCCCTGCCCGTACCTGTCATTGYGTCCA

1463 >C (p.Val408Ala) 3736 KCNA1 ATTTCAACTATTTCTACCAC]

NM_000174.4(GP9):c.212T>C ['CTTCAGTCCGTGCCCCCGGGAGCCTBTGACC

1464 (p.Phe71Ser) 2815 GP9 ACCTGCCCCAGCTGCAGACC]

NM_000174.4(GP9):c.l67T>C ['GCCCTGCCGGCCCGCACCCGCCACCYTCTGC

1465 (p.Leu56Pro) 2815 GP9 TGGCCAACAACAGCCTTCAG]

NM_000174.4(GP9):c.70T>C ['GGCCACCAAGGACTGCCCCAGCCCAYGTAC

1466 (p.Cys24Arg) 2815 GP9 CTGCCGCGCCCTGGAAACCAT']

NM_000174.4(GP9):c.20T>C ['TGTCCCATGCCTGCCTGGGGAGCCCYGTTCC

1467 (p.Leu7Pro) 2815 GP9 TGCTCTGGGCCACAGCAGAG]

NM_001001547.2(CD36):c.760T ['CGATTTTTAAACAGATGCAGCCTCABTTCCA

1468 >C (p.Phe254Leu) 948 CD36 CCTTTTGTTGAGAAAAGCCA']

NM_000212.2(ITGB3):c.2332T> ['CAACCCACTGTATAAAGAGGCCACGYCTAC

1469 C (p.Ser778Pro) -1 - CTTCACCAATATCACGTACCG]

NM_000212.2(ITGB3):c. l76T> ['GCTCCTGTCTTACAGGCCCTGCCTCYGGGCT

1470 C (p.Leu59Pro) 3690 ITGB3 CACCTCGCTGTGACCTGAAG']

NM_000301.3(PLG):c.l771T>C ['AGGGGGGTGTGTGGCCCACCCACATYCCTG

1471 (p.Ser591Pro) 5340 PLG GCCCTGGCAAGTCAGTCTTAG]

NM_001122757.2(POUlFl):c65 ['CAAACTGAAAGCAATATTATCCAAAYGGCT

1472 5T>C (p.Trp219Arg) 5449 POU1F1 GGAGGAAGCTGAGCAAGTAGG]

NM_000293.2(PHKB):c.2923T> ['ACCAACCCTGTCAGATATGACCATGHATGA

1473 C (p.Tyr975His) 5257 PHKB GATGAATTTCTCTCTCCTTGT']

NM_004577.3(PSPH):c.l55T>C ['CTCCCTCCTAGGACACGGCGAGCCAYGGGC

1474 (p.Met52Thr) 5723 PSPH GGGGCAGTGCCTTTCAAAGCT']

NM_000175.3 (GPI) :c .1574T>C ['CTGGGAAAGCAGCTGGCTAAGAAAABAGAG

1475 (p.Ile525Thr) 2821 GPI CCTGAGCTTGATGGCAGTGCT']

NM_000175.3 (GPI) :c .1016T>C ['TTTGGGTGTGAGACACACGCCATGCYGCCCT

1476 (p.Leu339Pro) 2821 GPI ATGACCAGTACCTGCACCGC]

NM_000478.4(ALPL) :c .1306T> ['ACGAGAGAATGTCTCCATGGTGGACYATGG

1477 C (p.Tyr436His) 249 ALPL TGAGACCTCCAGGACCCAGGG]

NM_000478.4(ALPL):c.979T>C ['GATCCTGCGGAAGAACCCCAAAGGCYTCTT

1478 (p.Phe327Leu) 249 ALPL CTTGCTGGTGGAAGGTAGGGA']

1479 NM_018849.2(ABCB4):c. l207T 5244 ABCB4 ['GGAGTTCAATGATGTTCACTTTTCTYACCCT >C (p.Tyr403His) TCTCGAGCTAACGTCAAGGT']

NM_198965.1(PTHLH):c.l79T> ['CAAGATTTACGGCGACGATTCTTCCYTCACC

1480 C (p.Leu60Pro) 5744 PTHLH ATCTGATCGCAGAAATCCAC]

NM_198965.1(PTHLH):c.l31T> ['AGAGCTGTGTCTGAACATCAGCTCCYCCATG

1481 C (p.Leu44Pro) 5744 PTHLH ACAAGGGGAAGTCCATCCAA']

NM_000315.2(PTH):c.52T>C ['AGTTATGATTGTCATGTTGGCAATTYGTTTT

1482 (p.CyslSArg) 5741 PTH CTTACAAAATCGGATGGGAA']

NM_000315.2(PTH):c.67T>C ['GTTGGCAATTTGTTTTCTTACAAAAYCGGAT

1483 (p.Ser23Pro) 5741 PTH GGGAAATCTGTTAAGTAAGT']

NM_003122.4(SPINKl):c.2T>C ['ACCTCTGGACGCAGAACTTCAGCCAYGAAG

1484 (p.MetlThr) 6690 SPINK1 GTAACAGGCATCTTTCTTCTC]

NM_003122.4(SPINKl):c.41T> ['ATCTTTCTTCTCAGTGCCTTGGCCCBGTTGA

1485 C (p.Leul4Pro) 6690 SPINK1 GTCTATCTGGTAAGTGTTGC]

NM_006194.3 (PAX9) : c.62T>C ['GGAGTGTTCGTGAACGGGAGGCCGCYGCCC

1486 (p.Leu21Pro) 5083 PAX9 AACGCCATCCGGCTTCGCATC]

NM_005188.3(CBL):c. ll l lT>C ['TTAATCAAAGGAACAATATGAATTAHACTG

1487 (p.Tyr371His) 867 CBL TGAGATGGGCTCCACATTCCA']

NM_005247.2(FGF3):c.466T>C ['CAGCGCCGAGAGACTGTGGTACGTGYCTGT

1488 (p.Serl56Pro) 2248 FGF3 GAACGGCAAGGGCCGGCCCCG]

NM_005247.2(FGF3):c.l7T>C ['GATGCCACGATGGGCCTAATCTGGCYGCTA

1489 (p.Leu6Pro) 2248 FGF3 CTGCTCAGCCTGCTGGAGCCC]

NM_000222.2(KIT) :c .1676T>C ['CCCATGTATGAAGTACAGTGGAAGGNTGTT

1490 (p.Val559Ala) 3815 KIT GAGGAGATAAATGGAAACAAT']

NM_005249.4(FOXGl):c.643T> ['CATCTACGAGTTCATCATGAAGAACYTCCCT

1491 C (p.Phe215Leu) 2290 FOXG1 TACTACCGCGAGAACAAGCA']

NM_001127500.1(MET):c.3446 ['CAATTTCTGACCGAGGGAATCATCAYGAAA

1492 T>C (p.Metl l49Thr) 4233 MET GATTTTAGTCATCCCAATGTC]

NM_020975.4(RET):c.l858T>C ['CTTCCCTGAGGAGGAGAAGTGCTTCNGCGA

1493 (p.Cys620Arg) 5979 RET GCCCGAAGACATCCAGGGTGA']

NM_020975.4(RET):c.l 900T>C ['CACAGATCCACTGTGCGACGAGCTGNGCCG

1494 (p.Cys634Arg) 5979 RET CACGGTGATCGCAGCCGCTGT']

NM_020975.4(RET):c.2753T>C ['TAGGGTCGGATTCCAGTTAAATGGAYGGCA

1495 (p.Met918Thr) 5979 RET ATTGAATCCCTTTTTGATCAT']

NM_020630.4(RET):c.l852T>C ['CAACTGCTTCCCTGAGGAGGAGAAGNGCTT

1496 (p.Cys618Arg) 5979 RET CTGCGAGCCCGAAGACATCCA']

NM_020630.4(RET):c.l825T>C ['GGGGATTAAAGCTGGCTATGGCACCNGCAA

1497 (p.Cys609Arg) 5979 RET CTGCTTCCCTGAGGAGGAGAA']

NM_013251.3(TAC3):c.269T>C ['ATGCATGACTTCTTTGTGGGACTTAYGGGCA

1498 (p.Met90Thr) 6866 TAC3 AGAGGAGCGTCCAGCCAGGT']

NM_006158.4(NEFL):c.281T>C ['ATCCGCACGCAGGAGAAGGCGCAGCYCCAG

1499 (p.Leu94Pro) 4747 NEFL GACCTCAATGACCGCTTCGCC]

NM_006177.3 (NRL) : c.479T>C ['TGCGGGCGCGACGAGGCGCTGCGGCYGAAG

1500 (p.Leul60Pro) 4901 NRL CAGAGGCGCCGCACGCTGAAG]

1501 NM_000432.3(MYL2):c.52T>C 4633 MYL2 ['AGCCGGGGGCGCCAACTCCAACGTGYTCTC (p.Phel8Leu) CATGTTCGAACAGACCCAAAT']

NM_000257.3(MYH7):c.l046T> ['TTCACTTCAGAGGAGAAAAACTCCAYGTAT

1502 C (p.Met349Thr) 4625 MYH7 AAGCTGACAGGCGCCATCATG]

NM_000257.3(MYH7):c.l594T> ['GCTTCCTCAGCCCATGGGCATCATGYCCATC

1503 C (p.Ser532Pro) 4625 MYH7 CTGGAAGAGGAGTGCATGTT']

NM_000257.3(MYH7):c.5378T> ['AACATGGAACAGACCATTAAGGACCYGCAG

1504 C (p.Leul793Pro) 4625 MYH7 CACCGGCTGGACGAAGCCGAG]

NM_001040113.1(MYHll):c.37 ['GAGGTGGAACATAAGAAGAAGAAGCYGGA

1505 91T>C (p.Leul264Pro) 4629 MYH11 GGCGCAGGTGCAGGAGCTGCAG]

NM_000530.6(MPZ):c.404T>C ['TGTGACGTCAAAAACCCTCCAGACAYAGTG

1506 (p.Ilel35Thr) 4359 MPZ GGCAAGACCTCTCAGGTCACG]

NM_000530.6(MPZ):c.341T>C ['CGCTGGAAGGATGGCTCCATTGTCAYACAC

1507 (p.Ilell4Thr) 4359 MPZ AACCTAGACTACAGTGACAAT']

NM_016835.4(MAPT):c. l839T> ['AGTCCAAGTGTGGCTCAAAGGATAAYATCA

1508 C (p.Asn613=) 4137 MAPT AACACGTCCCGGGAGGCGGCA']

NM_198159.2(MITF):c.l051T> ['GAACAAGGGAACCATCTTAAAAGCAYCCGT

1509 C (p.Ser351Pro) 4286 MITF GGACTATATCCGAAAGTTGCA']

NM_198159.2(MITF):c.l l95T> ['AATGCAGGCTCGAGCTCATGGACTTYCCCTT

1510 C (p.Ser399Pro) 4286 MITF ATTCCATCCACGGGTCTCTG]

NM_000426.3(LAMA2):c.7691T ['ACCAAGAATGAGTCCGGCATCATTCYTTTGG

1511 >C (p.Leu2564Pro) 3908 LAMA2 GAAGTGGAGGGACACCAGCA']

NM_000426.3(LAMA2):c.2584T ['ACAACCCTCTGTACCTGGAGGATCAYGTCA

1512 >C (p.Cys862Arg) 3908 LAMA2 GCCATGCCAATGCAATGACAA']

NM_002435.2(MPI):c.413T>C ['CCCGATGCCAACCACAAGCCAGAGAYGGCC

1513 (p.Metl38Thr) 4351 MPI ATTGCCCTCACCCCCTTCCAG]

NM_000239.2(LYZ):c.221T>C ['GGAGACAGAAGCACTGATTATGGGAYATTT

1514 (p.Ile74Thr) 4069 LYZ CAGATCAATAGCCGCTACTGG]

NM_000239.2(LYZ):c.244T>C ['GATATTTCAGATCAATAGCCGCTACHGGTGT

1515 (p.Trp82Arg) 4069 LYZ AATGATGGCAAAACCCCAGG]

NM_000233.3(LHCGR):c.l627T ['CAATGTGGTGGCCTTCTTCATAATTYGTGCT

1516 >C (p.Cys543Arg) -1 - TGCTACATTAAAATTTATTT']

NM_000233.3(LHCGR):c.l l93T ['AAACTTACAGTGCCTCGTTTTCTCAYGTGCA

1517 >C (p.Met398Thr) -1 - ATCTCTCCTTTGCAGACTTT']

NM_000233.3(LHCGR):c.391T> ['TCCTGTCCCTAATCACAGGAGCATCYGTAAC

1518 C (p.Cysl31Arg) -1 - ACAGGCATCAGAAAGTTTCC]

NM_000233.3(LHCGR):c.l l03T ['GACTTCCTTAGGGTCCTGATTTGGCYGATTA

1519 >C (p.Leu368Pro) -1 - ATATTCTAGCCATCATGGGA']

NM_000233.3(LHCGR):c.l505T ['TCTTCTCTAATTGCTATGTTGCCCCYTGTCGG

1520 >C (p.Leu502Pro) -1 - TGTCAGCAATTACATGAAG]

NM_170707.3(LMNA):c. l589T> ['TGCGGGAACAGCCTGCGTACGGCTCYCATC

1521 C (p.Leu530Pro) 4000 LMNA AACTCCACTGGGGAAGTAAGT']

NM_170707.3(LMNA):c. l l39T> ['GAGATCCACGCCTACCGCAAGCTCTYGGAG

1522 C (p.Leu380Ser) 4000 LMNA GGCGAGGAGGAGAGGTGGGCT']

1523 NM_002292.3(LAMB2):c.961T> 3913 LAMB2 ['CAAACACAACACACGTGGCCTCAACYGCGA C (p.Cys321Arg) GCAGTGTCAGGATTTCTATCG]

NM_000228.2(LAMB3):c.565- ['AAATCCATAAGGTTAAGTTGGACCTRCAGA

1524 3T>C 3914 LAMB 3 GGGAAGGGAAAGAGAAGCGCT']

NM_000421.3(KRT10):c.482T> ['CTGAATGACCGCCTGGCTTCCTACTYGGACA

1525 C (p.Leul61Ser) -1 - AAGTTCGGGCTCTGGAAGAA']

NM_000421.3(KRT10):c.449T> ['CTCTCTGGAAATGAAAAAGTAACCABGCAG

1526 C (p.Metl50Thr) -1 - AATCTGAATGACCGCCTGGCT']

NM_000422.2(KRT17):c.263T> ['CTGGCTGGAGGTGAGAAGGCCACCAHGCAG

1527 C (p.Met88Thr) 3872 KRT17 AACCTCAATGACCGCCTGGCC]

NM_000422.2(KRT17):c.284T> ['ACCATGCAGAACCTCAATGACCGCCHGGCC

1528 C (p.Leu95Pro) 3872 KRT17 TCCTACCTGGACAAGGTGCGT']

NM_000422.2(KRT17):c.296T> ['CTCAATGACCGCCTGGCCTCCTACCYGGACA

1529 C (p.Leu99Pro) 3872 KRT17 AGGTGCGTGCCCTGGAGGAG]

NM_005557.3(KRT16):c.395T> ['CTCAATGACCGCCTGGCCTCCTACCYGGACA

1530 C (p.Leul32Pro) 3868 KRT16 AGGTGCGTGCTCTGGAGGAG]

NM_005557.3(KRT16):c.362T> ['CTGGTGGGCAGTGAGAAGGTGACCAHGCAG

1531 C (p.Metl21Thr) 3868 KRT16 AACCTCAATGACCGCCTGGCC]

NM_000526.4(KRT14):c.l l51T ['ATGATTGGCAGCGTGGAGGAGCAGCYGGCC

1532 >C (p.Leu384Pro) 3861 KRT14 CAGCTCCGCTGCGAGATGGAG]

NM_000526.4(KRT14):c.356T> ['CTGGTGGGCAGTGAGAAGGTGACCAYGCAG

1533 C (p.Metl l9Thr) 3861 KRT14 AACCTCAATGACCGCCTGGCC]

NM_000526.4(KRT14):c.l243T ['GCGGCTGGAGCAGGAGATCGCCACCYACCG

1534 >C (p.Tyr415His) 3861 KRT14 CCGCCTGCTGGAGGGCGAGGA']

NM_153490.2(KRT13):c.356T> ['CTCAACGACCGCCTGGCTTCCTACCYGGAGA

1535 C (p.Leul l9Pro) 3860 KRT13 AGGTGCGCGCCCTGGAGGAG]

NM_002273.3 (KRT8) : c.160T>C ['CTTTCGCGGTGGCCTGGGCGGCGGCHATGGT

1536 (p.Tyr54His) 3856 KRT8 GGGGCCAGCGGCATGGGAGG]

NM_000424.3(KRT5):c.l388T> ['GAGCTCATGAACACCAAGCTGGCCCYGGAC

1537 C (p.Leu463Pro) 3852 KRT5 GTGGAGATCGCCACTTACCGC]

NM_000424.3(KRT5):c.980T>C ['TCTGACACCTCAGTGGTCCTCTCCAHGGACA

1538 (p.Met327Thr) 3852 KRT5 ACAACCGCAACCTGGACCTG]

NM_000424.3(KRT5):c.20T>C ['GCCACCATGTCTCGCCAGTCAAGTGYGTCCT

1539 (p.Val7Ala) 3852 KRT5 TCCGGAGCGGGGGCAGTCGT']

NM_000424.3(KRT5):c.541T>C ['CAAGACCCTCAACAATAAGTTTGCCYCCTTC

1540 (p.Serl81Pro) 3852 KRT5 ATCGACAAGGTGAGCTACGA']

NM_000208.2(INSR):c.779T>C ['TGCGTGGCCTGCCGCAACTTCTACCYGGACG

1541 (p.Leu260Pro) 3643 INSR GCAGGTGTGTGGAGACCTGC]

NM_000208.2(INSR) :c .164T>C ['TTGCATGAGCTGGAGAATTGCTCTGYCATCG

1542 (p.Val55Ala) 3643 INSR AAGGACACTTGCAGATACTC]

NM_002198.2(IRFl):c.31T>C ['CATCACTCGGATGCGCATGAGACCCYGGCT

1543 (p.Trpl lArg) 3659 IRF1 AGAGATGCAGATTAATTCCAA']

NM_000213.3 (ITGB4) : c.467T> ['AACCTCAAGAAGATGGGGCAGAACCYGGGT

1544 C (p.Leul56Pro) 3691 ITGB4 ACGGCAGGGCCAGAGTGGAGG]

1545 NM_000213.3 (ITGB4) : c.1684T> 3691 ITGB4 ['CCGAGGACGCTGCTCCATGGGCCAGYGTGT C (p.Cys562Arg) GTGTGAGCCTGGTTGGACAGG]

NM_000213.3(ITGB4):c. l l2T> ['CTGCAAGAAGGCCCCAGTGAAGAGCYGCAC

1546 C (p.Cys38Arg) 3691 ITGB4 GGAGTGTGTCCGTGTGGATAA]

M_000454.4(SODl):c.338T>C ['ATCTCACTCTCAGGAGACCATTGCAYCATTG

1547 (p.Ilell3Thr) 6647 SOD1 GCCGCACACTGGTGGTAAGT']

M_000454.4(SODl):c.434T>C ['AAGACAGGAAACGCTGGAAGTCGTTYGGCT

1548 (p.Leul45Ser) 6647 SOD1 TGTGGTGTAATTGGGATCGCC]

M_000454.4(SODl):c.455T>C ['CGTTTGGCTTGTGGTGTAATTGGGAYCGCCC

1549 (p.Ilel52Thr) 6647 SOD1 AATAAACATTCCCTTGGATG']

NM_001025107.2(ADAR):c. l88 ['ACCAGACTTTCTTTTTGTAGGTTTCYCTACA

1550 3T>C (p.Leu628Pro) 103 ADAR GTGAGTTAATGAAATACAAC]

NM_001025107.2(ADAR):c.260 ['TCCAAAAAGAACATTTTTCTTCTATYTAAGA

1551 9T>C (p.Phe870Ser) 103 ADAR AGCTCTGCTCCTTCCGTTAC']

NM_002185.3 (IL7R) :c .197T>C ['CCATATTTCAAATTCCAGATTGGTGRTGTTG

1552 (p.Ile66Thr) 3575 IL7R ACATCTGGGTCCTCAAAAGC]

NM_033500.2(HKl):c. l550T>C ['ACTGCAACAGAGAATGGTGACTTCTYGGCC

1553 (p.Leu517Ser) 3098 HK1 CTGGATCTTGGAGGAACCAAT']

NM_000184.2(HBG2):c.- ['CTTCCCCACACTATCTCAATGCAAAYATCTG

1554 228T>C 3048 HBG2 TCTGAAACGGTCCCTGGCTA']

NM_000184.2(HBG2):c. l25T>C ['GTTGTCTACCCATGGACCCAGAGGTYCTTTG

1555 (p.Phe42Ser) 3048 HBG2 ACAGCTTTGGCAACCTGTCC]

NM_000559.2(HBGl):c.- ['TAGCAGTATCCTCTTGGGGGCCCCTYCCCCA

1556 251T>C 3047 HBG1 CACTATCTCAATGCAAATAT']

['TCTCACAAACTAATGAAACCCTGCTYATCTT

1557 NM_000519.3(HBD):c.-127T>C 3045 HBD AAACCAACCTGCTCACTGGA']

NM_000518.4(HBB):c.257T>C ['CACCTGGACAACCTCAAGGGCACCTYTGCC

1558 (p.Phe86Ser) 3043 HBB ACACTGAGTGAGCTGCACTGT']

NM_000518.4(HBB):c.l28T>C ['GTCTACCCTTGGACCCAGAGGTTCTBTGAGT

1559 (p.Phe43Ser) 3043 HBB CCTTTGGGGATCTGTCCACT']

NM_000518.4(HBB):c.337T>C ['ACAGCTCCTGGGCAACGTGCTGGTCYGTGTG

1560 (p.Cysl l3Arg) 3043 HBB CTGGCCCATCACTTTGGCAA']

NM_000518.4(HBB):c.l27T>C ['GGTCTACCCTTGGACCCAGAGGTTCBTTGAG

1561 (p.Phe43Leu) 3043 HBB TCCTTTGGGGATCTGTCCAC']

NM_000518.4(HBB):c.332T>C ['CTCCCACAGCTCCTGGGCAACGTGCYGGTCT

1562 (p.Leull lPro) 3043 HBB GTGTGCTGGCCCATCACTTT']

['GGTGGTGAGGCCCTGGGCAGGTTGGHATCA

1563 NM_000518.4(HBB):c.92+6T>C 3043 HBB AGGTTACAAGACAGGTTTAAG]

NM_000518.4(HBB):c.344T>C ['CTGGGCAACGTGCTGGTCTGTGTGCYGGCCC

1564 (p.Leull5Pro) 3043 HBB ATCACTTTGGCAAAGAATTC]

NM_000517.4(HBA2):c.427T>C ['CACCGTGCTGACCTCCAAATACCGTNAAGCT

1565 (p.Terl43Gln) 3040 HBA2 GGAGCCTCGGTAGCCGTTCC]

NM_000517.4(HBA2):c.2T>C ['CCACAGACTCAGAGAGAACCCACCAYGGTG

1566 (p.MetlThr) 3040 HBA2 CTGTCTCCTGCCGACAAGACC]

1567 NM_000517.4(HBA2):c.89T>C 3040 HBA2 ['GCTGGCGAGTATGGTGCGGAGGCCCYGGAG (p.Leu30Pro) AGGTGAGGCTCCCTCCCCTGC]

NM_006121.3(KRTl):c.482T>C ['CAAGAAGTCACTATCAACCAGAGCCYTCTTC

1568 (p.Leul61Pro) 3848 KRT1 AGCCCCTCAATGTGGAGATT']

NM_006121.3(KRTl):c.l436T> ['ACCAAGCTGGCCCTGGATCTGGAGAYTGCC

1569 C (p.Ile479Thr) 3848 KRT1 ACCTACAGGACCCTCCTGGAG]

NM_006121.3(KRTl):c.l424T> ['GAGCTGATGAACACCAAGCTGGCCCYGGAT

1570 C (p.Leu475Pro) 3848 KRT1 CTGGAGATTGCCACCTACAGG]

NM_001077488.3(GNAS):c.299 ['AAAGTGCAGGACATCAAAAACAACCYGAAA

1571 T>C (p.LeulOOPro) 2778 GNAS GAGGCGATTGAAGTACGTGCT']

NM_000515.4(GHl):c.291+6T> ['AGGAAACACAACAGAAATCCGTGAGYGGAT

1572 C 2688 GH1 GCCTTCTCCCCAGGCGGGGAT']

NM_002087.3 (GRN) : c.2T>C ['TCCTTGGTACTTTGCAGGCAGACCAYGTGGA

1573 (p.MetlThr) 2896 GRN CCCTGGTGAGCTGGGTGGCC]

NM_021957.3(GYS2):c. l447T> ['GGTGATTTTGCACCCAGAGTTTCTAYCCTCC

1574 C (p.Ser483Pro) 2998 GYS2 ACCAGTCCCTTACTACCCAT']

NM_001083112.2(GPD2):c.1904 ['AGGTATAAGAAGAGATTTCATAAGTYTGAT

1575 T>C (p.Phe635Ser) 2820 GPD2 GCAGACCAGAAAGGCTTTATT']

NM_000340. l(SLC2A2):c.1166 ['ATCTTCATGTCAGTGGGACTTGTGCBGCTGG

1576 T>C (p.Leu389Pro) 6514 SLC2A2 TAAGTTTGGTGCCTGCACTG]

NM_005271.3(GLUDl):c.l501T ['GTGTTCTTTTCCCTAATAGGGTGCAYCTGAG

1577 >C (p.Ser501Pro) 2746 GLUD1 AAAGACATCGTGCACTCTGG]

NM_000162.3(GCK):c.391T>C ['CTTCGACTACATCTCTGAGTGCATCYCCGAC

1578 (p.Serl31Pro) 2645 GCK TTCCTGGACAAGCATCAGAT']

NM_001018077.1(NR3Cl):c. l71 ['CTCAACATGTTAGGAGGGCGGCAAGYGATT

1579 2T>C (p.Val571Ala) 2908 NR3C1 GCAGCAGTGAAATGGGCAAAG]

NM_001018077.1(NR3Cl):c.231 ['TCAAATGGAAATATCAAAAAACTTCYGTTTC

1580 8T>C (p.Leu773Pro) 2908 NR3C1 ATCAAAAGTGACTGCCTTAA']

NM_001018077.1(NR3Cl):c.220 ['GGTTGAAAATCTCCTTAACTATTGCYTCCAA

1581 9T>C (p.Phe737Leu) 2908 NR3C1 ACATTTTTGGATAAGACCAT']

NM_002055.4(GFAP):c. l055T> ['CGCCACTTGCAGGAGTACCAGGACCYGCTC

1582 C (p.Leu352Pro) 2670 GFAP AATGTCAAGCTGGCCCTGGAC]

NM_002353.2(TACSTD2):c.557 ['CGGCTCTTCCGCGAGCGCTATCGGCYGCACC

1583 T>C (p.Leul86Pro) 4070 TACSTD2 CCAAGTTCGTGGCGGCCGTG]

NM_000821.6(GGCX):c.896T> ['TTTCTCCCTGCTTTCCTAGGTATGTYCTCCTA

1584 C (p.Phe299Ser) 2677 GGCX CGTCATGCTGGCCAGCAGC]

NM_000145.3(FSHR):c.479T>C ['CAAGATAACATAAACATCCACACAAYTGAA

1585 (p.Ilel60Thr) 2492 FSHR AGAAATTCTTTCGTGGGGCTG]

NM_000145.3(FSHR):c. l634T> ['CTCAATGTCCTGGCCTTTGTGGTCAYCTGTG

1586 C (p.Ile545Thr) 2492 FSHR GCTGCTATATCCACATCTAC]

NM_182925.4(FLT4):c.3131T>C ['AGAGACCTGGCTGCTCGGAACATTCYGCTGT

1587 (p.Leul044Pro) 2324 FLT4 CGGAAAGCGACGTGGTGAAG]

NM_182925.4(FLT4):c.3257T>C ['CTGAAGTGGATGGCCCCTGAAAGCAYCTTC

1588 (p.Ilel086Thr) 2324 FLT4 GACAAGGTGTACACCACGCAG]

1589 NM_023110.2(FGFRl):c.899T> 2260 FGFR1 ['CACATCGAGGTGAATGGGAGCAAGAYTGGC C (p.Ile300Thr) CCAGACAACCTGCCTTATGTC']

NM_023110.2(FGFRl):c.1141T ['CCTGTACCTGGAGATCATCATCTATYGCACA

1590 >C (p.Cys381Arg) 2260 FGFR1 GGGGCCTTCCTCATCTCCTG]

NM_000138.4(FBNl):c.4987T> [TCCTGGAATCTGTGGTCCAGGGACAYGTTAC

1591 C (p.Cysl663Arg) 2200 FBN1 AACACCGTTGGCAACTACAC]

NM_000138.4(FBNl):c.3220T> ['CTGTTTTTGTGCAGACATTGACGAAYGCCGC

1592 C (p.Cysl074Arg) 2200 FBN1 ATATCTCCTGACCTCTGTGG]

NM_000138.4(FBNl):c.3793T> ['TATCCCTGGAGAGTACAGGTGCTTGYGTTAT

1593 C (p.Cysl265Arg) 2200 FBN1 GATGGATTCATGGCATCTGA']

NM_000043.4(FAS):c.532T>C ['ATCCAGATCTAACTTGGGGTGGCTTYGTCTT

1594 (p.Cysl78Arg) 355 FAS CTTCTTTTGCCAATTCCACT']

NM_000043.4(FAS):c.651+2T> ['CATGAATCTCCAACTTTAAATCCTGHAGGTA

1595 C 355 FAS TTGAAATAGGTATCAGCTTT']

NM_000129.3(F13Al):c.728T>C ['ATCCTGGACACTTGCCTGTATGTGAYGGACA

1596 (p.Met243Thr) 2162 F13A1 GAGCACAAATGGACCTCTCT']

NM_000186.3 (CFH) : c.1606T>C ['GCTGAATGACACATTGGACTATGAAYGCCA

1597 (p.Cys536Arg) 3075 CFH TGATGGTTATGAAAGCAATAC]

NM_000123.3(ERCC5):c.2573T ['AAGTTAATAAATTTGGCTTATTTGCYTGGAA

1598 >C (p.Leu858Pro) -1 - GTGATTATACCGAAGGAATA']

NM_000122.1(ERCC3):c.296T> ['CCAGTTTACAAATATGCCCAAGACTYCTTGG

1599 C (p.Phe99Ser) 2071 ERCC3 TGGCTATTGCAGAGCCAGTG]

NM_001113755.2(TYMP):c.854 ['CTGGGTCGCTGCGTGGGCCACGCCCYGGAG

1600 T>C (p.Leu285Pro) 1890 TYMP GTGGAGGAGGCGCTGCTCTGC]

NM_000118.3(ENG):c.2T>C ['CGCACAGGCCCCCACGTGGACAGCAYGGAC

1601 (p.MetlThr) 2022 ENG CGCGGCACGCTCCCTCTGGCT']

NM_203342.2(EPB41):c.2T>C [' AAACC AATC AGAAAAC AC AGGAAC AB GC AC

1602 (p.MetlThr) 2035 EPB41 TGCAAGGTTTCTTTGTTGGAT']

NM_001972.2(ELANE):c.211T> ['CAACTTCGTCATGTCGGCCGCGCACYGCGTG

1603 C (p.Cys71Arg) 1991 ELANE GCGAATGTGTGAGTAGCCGG]

NM_000400.3(ERCC2):c.l454T ['ACCATGGCAACCTTCACCATGACGCYGGCA

1604 >C (p.Leu485Pro) 2068 ERCC2 CGGGTCTGCCTCTGCCCTATG]

NM_000281.3(PCBDl):c.244T> ['CCACATCACGCTGAGCACCCATGAGYGTGC

1605 C (p.Cys82Arg) 5092 PCBD1 CGGCCTTTCAGAACGGGACAT']

NM_001927.3(DES):c. l034T>C ['CCCCCTCTCCTGCAGAACGATTCCCYGATGA

1606 (p.Leu345Pro) 1674 DES GGCAGATGCGGGAATTGGAG]

NM_001927.3(DES):c. ll54T>C ['CTCAAGGATGAGATGGCCCGCCATCYGCGC

1607 (p.Leu385Pro) 1674 DES GAGTACCAGGACCTGCTCAAC]

NM_000498.3(CYPl lB2):c.l l57 ['GTTCTGAAGCACCAAGTCTGAGCTCRCCACT

1608 T>C (p.Val386Ala) -1 - CGCTCCAAAAACAGACCCAC]

NM_000498.3(CYPl lB2):c.l382 ['CGGCGCCTGGCAGAGGCAGAGATGCYGCTG

1609 T>C (p.Leu461Pro) -1 - CTGCTGCACCACGTAAGCAGG]

NM_001886.2(CRYBA4):c.281T ['TACCCCGCCGAGAGGCTCACCTCCTYCCGGC

1610 >C (p.Phe94Ser) 1413 CRYBA4 CTGCGGCCTGTGCTGTAAGT']

1611 NM_001886.2(CRYBA4):c.206T 1413 CRYBA4 ['GGCTTCCAAGGGCAGCAGTACATTCYGGAA >C (p.Leu69Pro) CGAGGCGAATATCCAAGCTGG]

NM_000762.5(CYP2A6):c.670T ['GCAACCCCAGCTCTATGAGATGTTCYCTTCG

1612 >C (p.Ser224Pro) -1 - GTGATGAAACACCTGCCAGG]

NM_000165.4(GJAl):c.52T>C ['ACTCCTTGACAAGGTTCAAGCCTACYCAACT

1613 (p.Serl8Pro) 2697 GJA1 GCTGGAGGGAAGGTGTGGCT']

NM_000165.4(GJAl):c.32T>C ['GACTGGAGCGCCTTAGGCAAACTCCYTGAC

1614 (p.LeullPro) 2697 GJA1 AAGGTTCAAGCCTACTCAACT']

M_004004.5 (GJB2) :c .101 T>C ['CTCCTTTGCAGCCACAACGAGGATCVTAATG

1615 (p.Met34Thr) 2706 GJB2 CGAAAAATGAAGAGGACGGT']

M_004004.5(GJB2):c.229T>C ['CTTCCCCATCTCCCACATCCGGCTAYGGGCC

1616 (p.Trp77Arg) 2706 GJB2 CTGCAGCTGATCTTCGTGTC]

M_004004.5(GJB2):c.269T>C ['ATCTTCGTGTCCACGCCAGCGCTCCYAGTGG

1617 (p.Leu90Pro) 2706 GJB2 CCATGCACGTGGCCTACCGG]

NM_005215.3(DCC):c.503T>C ['AAGTGTGAAGTCATTGGGGAGCCCAYGCCA

1618 (p.Metl68Thr) 1630 DCC ACAATCCACTGGCAGAAGAAC]

NM_001849.3(COL6A2):c.2329 ['GAGTGAAAACCTCTACTCCATCGCCYGCGA

1619 T>C (p.Cys777Arg) 1292 COL6A2 CAAGCCACAGCAGGTGCGCAA']

NM_000090.3(COL3Al):c.582+ ['CTGGTCATCCTGGTTCCCCTGTAAGHATAGC

1620 6T>C 1281 COL3A1 CATTGGTGGTGTTTTCTTCC]

NM_000089.3(COLlA2):c.279+ ['GTTGGACTTGGCCCTGGACCAATGGYATGCT

1621 2T>C 1278 COL1A2 TATCTGTTTATCTTAGCCAA']

NM_000089.3(COLlA2):c.3105 ['TTGCAAGGTCTGCCTGGTATCGCTGYAAGTA

1622 +2T>C 1278 COL1A2 AACTGTAGCCATCTCGCACA]

NM_000088.3(COLlAl):c.4391 ['TTCGACGTTGGCCCTGTCTGCTTCCYGTAAA

1623 T>C (p.Leul464Pro) 1277 COL1A1 CTCCCTCCATCCCAACCTGG]

NM_000493.3 (COL 10 Al ) :c .184 ['AAAGGGACTCATGTTTGGGTAGGCCYGTAT

1624 1T>C (p.Leu614Pro) -1 - AAGAATGGCACCCCTGTAATG]

NM_000493.3 (COL 10 Al ) :c .177 ['TGACCCAAGGACTGGAATCTTTACTYGTCAG

1625 1T>C (p.Cys591Arg) -1 - ATACCAGGAATATACTATTT']

NM_000493.3(COL10Al):c.l95 ['CGATCTCACAGAAAATGACCAGGTGYGGCT

1626 1T>C (p.Trp651Arg) -1 - CCAGCTTCCCAATGCCGAGTC]

NM_000493.3(COL10Al):c.201 ['ATACTCCTCTGAGTATGTCCACTCCYCTTTCT

1627 1T>C (p.Ser671Pro) -1 - CAGGATTCCTAGTGGCTCC]

NM_000493.3(COL10Al):c.l79 ['TCAGATACCAGGAATATACTATTTTYCATAC

1628 8T>C (p.Ser600Pro) -1 - CACGTGCATGTGAAAGGGAC]

NM_020549.4(CHAT):c.629T>C ['ATGTATCTCAACAACCGCCTGGCCCYGCCTG

1629 (p.Leu210Pro) 1103 CHAT TCAACTCCAGCCCTGCCGTG]

NM_020549.4(CHAT):c.914T>C ['ATCATGCCGGAGCCTGAGCACGTCABCGTA

1630 (p.Ile305Thr) 1103 CHAT GCCTGCTGCAATCAGGTAAGC]

NM_020549.4(CHAT):c.l007T> ['GATCTGTTCACTCAGTTGAGAAAGAYAGTC

1631 C (p.Ile336Thr) 1103 CHAT AAAATGGCTTCCAACGAGGAC]

NM_001822.5 (CHN1 ) : c.427T>C ['TGCCAAGATGACGATAAACCCAATTYATGA

1632 (p.Tyrl43His) 1123 CHN1 GCACGTAGGATACACAACCTT']

1633 NM_001904.3(CTNNBl):c. l33T 1499 CTNNB1 ['TTCTGGTGCCACTACCACAGCTCCTBCTCTG >C (p.Ser45Pro) AGTGGTAAAGGCAATCCTGA]

NM_004056.4(CA8):c.298T>C ['ACATATATTTTCTTTTTCAGTTCTTYCGGGAG

1634 (p.SerlOOPro) 767 CA8 GACCATTGCCTCAAGGGCA]

NM_016124.4(RHD):c.329T>C ['CCTTCTGGGAAGGTGGTCATCACACYGTTCA

1635 (p.LeullOPro) 6007 RHD GGTATTGGGATGGTGGCTGG]

NM_015865.6(SLC14Al):c.871 ['CTTTGGACTCTGGGGTTTCAACAGCYCTCTG

1636 T>C (p.Ser291Pro) 6563 SLC14A1 GCCTGCATTGCAATGGGAGG]

NM_001250.5(CD40):c.247T>C ['GACACACTGCCACCAGCACAAATACYGCGA

1637 (p.Cys83Arg) 958 CD40 CCCCAGTGCGTGCGCTGTTGG]

NM_000342.3(SLC4Al):c.2317 ['AGTGTGCGGCTCCCCCACAGGCCTGYCCATC

1638 T>C (p.Ser773Pro) 6521 SLC4A1 CTCATGGAGCCCATCCTGTC]

NM_001681.3 (ATP2 A2) :c .1678 ['GGGTAGTGGCAGCGACACACTGCGAYGCCT

1639 T>C (p.Cys560Arg) 488 ATP2A2 GGCCCTGGCCACTCATGACAA']

NM_001082971.1(DDC):c.925T ['TCCCCACAAATGGCTATTGGTGAATYTTGAC

1640 >C (p.Phe309Leu) 1644 DDC TGTTCTGCCATGTGGTAAGT']

NM_031226.2(CYP19Al):c.743 ['ATACAAAAAGTATGAGAAGTCTGTGYAAGT

1641 +2T>C -1 - AATACAACTTTGGAAGATTTA']

NM_000486.5 (AQP2) : c.646T>C ['ACCCCTGGTGGGCGCCATCCTGGGCYCCCTC

1642 (p.Ser216Pro) -1 - CTCTACAACTACGTGCTGTT']

NM_000041.3 (APOE) : c.388T>C ['GCTGGGCGCGGACATGGAGGACGTGYGCGG

1643 (p.Cysl30Arg) 348 APOE CCGCCTGGTGCAGTACCGCGG]

NM_000041.3 (APOE) : c.137T>C ['TGGCAGAGCGGCCAGCGCTGGGAACYGGCA

1644 (p.Leu46Pro) 348 APOE CTGGGTCGCTTTTGGGATTAC]

NM_000039.1(APOAl):c.220T> ['CTCCAGCCTAAAGCTCCTTGACAACYGGGA

1645 C (p.Trp74Arg) -1 - CAGCGTGACCTCCACCTTCAG]

NM_000039.1(APOAl):c.341T> ['CTGAGGCAGGAGATGAGCAAGGATCYGGAG

1646 C (p.Leul l4Pro) -1 - GAGGTGAAGGCCAAGGTGCAG]

NM_000039.1(APOAl):c.593T> ['TACAGCGACGAGCTGCGCCAGCGCTYGGCC

1647 C (p.Leul98Ser) 335 APOAl GCGCGCCTTGAGGCTCTCAAG]

NM_000416.2(IFNGRl):c.260T ['AATATTTCTCATCATTATTGTAATAYTTCTG

1648 >C (p.Ile87Thr) 3459 IFNGR1 ATCATGTTGGTGATCCATCA]

NM_000488.3 (SERPINC 1 ) : c.114 ['TGTCGATCTGTTCAGCCCTGAAAAGYCCAAA

1649 1T>C (p.Ser381Pro) 462 SERPINC 1 CTCCCAGGTTTGTCTAGGAA']

NM_000488.3 (SERPINC 1 ) : c.442 ['GTTTGACACCATATCTGAGAAAACAYCTGAT

1650 T>C (p.Serl48Pro) 462 SERPINC 1 CAGATCCACTTCTTCTTTGC]

NM_000488.3 (SERPINC 1 ) : c.68 ['AAGGTTTATCTTTTGTCCTTGCTGCYCATTG

1651 T>C (p.Leu23Pro) 462 SERPINC 1 GCTTCTGGGACTGCGTGACC]

NM_000488.3 (SERPINC 1 ) : c.667 ['CAGAGCGGCCATCAACAAATGGGTGYCCAA

1652 T>C (p.Ser223Pro) 462 SERPINC 1 TAAGACCGAAGGCCGAATCAC]

NM_000488.3(SERPINCl):c379 ['TTTTGCTATGACCAAGCTGGGTGCCYGTAAT

1653 T>C (p.Cysl27Arg) 462 SERPINC 1 GACACCCTCCAGCAACTGAT']

NM_001085.4(SERPINA3):c23 ['GATAAGAATGTCATCTTCTCCCCACYGAGCA

1654 3T>C (p.Leu78Pro) 12 SERPINA3 TCTCCACCGCCTTGGCCTTC]

1655 NM_000341.3(SLC3Al):c. l400 6519 SLC3A1 ['AATCAGTATGTCAACGTGATGAACAHGCTTC T>C (p.Met467Thr) TTTTCACACTCCCTGGAACT']

NM_000341.3(SLC3Al):c.2033 ['AATCGAGCATGCTATTCCAGTGTACYGAAC

1656 T>C (p.Leu678Pro) -1 - ATACTGTATACCTCGTGTTAG]

NM_000021.3(PSENl):c.749T> ['CCTGAATGGACTGCGTGGCTCATCTYGGCTG

1657 C (p.Leu250Ser) 5663 PSEN1 TGATTTCAGTATATGGTAAA']

NM_000021.3(PSENl):c.338T> ['TTTTATACCCGGAAGGATGGGCAGCYGTAC

1658 C (p.Leul l3Pro) 5663 PSEN1 GTATGAGTTTTGTTTTATTAT']

NM_000021.3(PSENl):c.497T> ['CTTTTCTAGGTCATCCATGCCTGGCBTATTAT

1659 C (p.Leul66Pro) 5663 PSEN1 ATCATCTCTATTGTTGCTG]

NM_000021.3(PSENl):c.254T> ['TATGGCGCCAAGCATGTGATCATGCYCTTTG

1660 C (p.Leu85Pro) 5663 PSEN1 TCCCTGTGACTCTCTGCATG]

NM_001151.3(SLC25A4):c.293 ['GCCTTCAAGGACAAGTACAAGCAGCYCTTC

1661 T>C (p.Leu98Pro) 291 SLC25A4 TTAGGGGGTGTGGATCGGCAT']

NM_001100.3(ACTAl):c.287T> ['TGGCACCACACCTTCTACAACGAGCYTCGCG

1662 C (p.Leu96Pro) 58 ACTA1 TGGCTCCCGAGGAGCACCCC]

NM_001100.3(ACTAl):c.668T> ['AAGGAGAAGCTGTGCTACGTGGCCCYGGAC

1663 C (p.Leu223Pro) 58 ACTA1 TTCGAGAACGAGATGGCGACG]

NM_000485.2(APRT):c.407T>C ['CTCACCCTCCCATCCCCAGGAACCAYGAAC

1664 (p.Metl36Thr) 353 APRT GCTGCCTGTGAGCTGCTGGGC]

NM_000485.2(APRT):c.329T>C ['CACCACTTCCCACTCCAGGCTGAGCYGGAG

1665 (p.LeullOPro) 353 APRT ATTCAGAAAGACGCCCTGGAG]

NM_001614.3(ACTGl):c.l l09T ['TACGACGAGTCGGGCCCCTCCATCGYCCACC

1666 >C (p.Val370Ala) 71 ACTG1 GCAAATGCTTCTAAACGGAC]

NM_000751.2(CHRND):c.283T ['CCGGCTGAAGTGGAATGCTGAAGAAYTTGG

1667 >C (p.Phe95Leu) 1144 CHRND AAACATCAGTGTCCTGCGCCT']

NM_000751.2(CHRND):c.l88T ['GCCCTGGCCCTCACACTCTCCAACCYCATCT

1668 >C (p.Leu63Pro) 1144 CHRND CCCTGGTGAGAGGCCCTCCG]

NM_001039523.2(CHRNAl):c.9 ['CTCTGTCTTACTGTCTTTGACTGTGYTCCTTC

1669 01T>C (p.Phe301Leu) 1134 CHRNA1 TGGTCATCGTGGAGCTGAT']

NM_001004127.2(ALGl l):c.257 44013 ['GGAGAAAGAGTTTTATGGTGTGCTTYAAGA

1670 T>C (p.Leu86Ser) 8 ALG11 GCCCTGCAGAAAAAGTAGGTA']

['AGAGGGAGCTAGGAGGCTAGCATAGRAAGG

AGARAAGGAAAAAGACTTTGA',

'TATAAAGACTGAGGGGCAAACAGCASGGGA

AATGAGGGGCATAGGGATAAG,

'CGCAGACAGAAGGGCTGGGACGGCTRTCAG

1671 CGCCTGTGCTTCCAAGRTAAG,

NM_002036.3(ACKRl):c.- ATCAGGAAGCCTTACCCCACGCCCAYTGCCT 1674 67T>C 2532 ACKR1 GCACAAGCCTCAGGCCTATG]

NM_014053.3(FLVCRl):c.574T ['CAACTGCCTGGGTGCCTGGATCAAGYGCGG

1675 >C (p.Cysl92Arg) 28982 FLVCR1 CAGTGTGCAGCAGCATCTCTT']

NM_004268.4(MED17):c.1112T ['TGTCCGGAGGACCACCTTTATGTCCYAGAGC

1676 >C (p.Leu371Pro) 9440 MED17 ATAATTTGCATCTACTGATT']

1677 NM_024411.4(PDYN):c.632T>C 5173 PDYN ['CTGTACAAACGCTATGGGGGCTTCTYGCGGC (p.Leu211Ser) GCATTCGTCCCAAGCTCAAG']

NM_000018.3 (ACAD VL) :c .848 ['GTGAAGGAGAAGATCACAGCTTTTGYGGTG

1678 T>C (p.Val283Ala) 37 ACADVL GAGAGGGGCTTCGGGGGCATT']

NM_000021.3(PSENl):c.l l75T> ['GGAGATTTCATTTTCTACAGTGTTCYGGTTG

1679 C (p.Leu392Pro) 5663 PSEN1 GTAAAGCCTCAGCAACAGCC]

NM_000083.2(CLCNl):c.857T> ['CCACACTTCTGTGCCCCTGCAGGAGYGCTAT

1680 C (p.Val286Ala) 1180 CLCN1 TTAGCATCGAGGTCACCTCC]

NM_000083.2(CLCNl):c.920T> ['GTTCGGAACTACTGGAGAGGATTCTYTGCA

1681 C (p.Phe307Ser) 1180 CLCN1 GCCACGTTCAGCGCCTTTGTG]

NM_000157.3(GBA):c.703T>C ['CAATGGAGCGGTGAATGGGAAGGGGYCACT

1682 (p.Ser235Pro) 2629 GBA CAAGGGACAGCCCGGAGACAT']

NM_000166.5(GJBl):c.l45T>C ['AGAGAGTGTGTGGGGTGATGAGAAAYCTTC

1683 (p.Ser49Pro) 2705 GJB1 CTTCATCTGCAACACACTCCA]

['ATATCCCCGTTTACACACAAATTCARCTGAT TCACCTGTTCTCGAATAAAG',

1684 'GAACTTATCATTGCTGCTTTTGATTaagatattggtc

NM_000186.3 (CFH) : c.3590T>C aaagagtacaaact',

1686 (p.Vall l97Ala) 3075 CFH 'ttcagctataatatgaataagaacttggaatcaaacatagagatctagtga']

NM_000195.4(HPSl):c.2003T> ['GGGGATGACAGACAGGTGCAGGGCCRGCAG

1687 C (p.Leu668Pro) 3257 HPS1 CTCGTAGCACCTGACAGCCTC]

NM_000195.4(HPSl):c.716T>C ['GCTGGGGTAGAGGTCCTGAACCAGGRGGAT

1688 (p.Leu239Pro) 3257 HPS1 GAGGGCAAGCAGGTCGGCCGG]

NM_000334.4(SCN4A):c.4468T ['CCTCTTCAACATCGGCCTCCTCCTCYTCCTG

1689 >C (p.Phel490Leu) 6329 SCN4A GTCATGTTCATCTACTCCAT']

NM_000352.4(ABCC8):c.257T> ['ACCTTCATGCTGCTCTTCGTCCTGGBGTGTG

1690 C (p.Val86Ala) 6833 ABCC8 AGATTGCAGAGGGCATCCTG]

NM_000352.4(ABCC8):c.404T> ['ATCGAGACTTCCAACTTCCCCAAGCYGCTAA

1691 C (p.Leul35Pro) 6833 ABCC8 TTGGTAGGTGAGGTGTAGGA']

NM_000352.4(ABCC8):c.674T> ['TTCCTGCAGCCCTTCGTGAATCTGCYGTCCA

1692 C (p.Leu225Pro) 6833 ABCC8 AAGGCACCTACTGGTGGATG]

NM_000430.3(PAFAHlBl):c56 PAFAHIB ['ATTACTTCATAATATATTGCTGTTAYGTGTTT

1693 9-10T>C 5048 1 TAGGCCATGACCACAATGT']

NM_000525.3(KCNJll):c.l03T ['CCGTGCCCGCCAGCGGAGGGCCCGCBTTGT

1694 >C (p.Phe35Leu) 3767 KCNJ11 GTCCAAGAAAGGCAACTGCAA']

NM_000525.3(KCNJll):c.755T ['GTGGGTGGCAACAGCATCTTCCTGGYGGCC

1695 >C (p.Val252Ala) 3767 KCNJ11 CCGCTGATCATCTACCATGTC]

NM_000528.3(MAN2Bl):c2426 ['GGCAGCAGCCTGAGAGATGGCTCGCYGGAG

1696 T>C (p.Leu809Pro) 4125 MAN2B1 CTCATGGTGAGTGGGTCAGAG]

NM_001034850.2(FAM134B):c. ['GACTTTTCAGCTCTTTGTCCTAAGGYATTTTT

1697 873+2T>C 54463 FAM134B TGTTTAGTTTTCAATTTGT']

NM_001457.3(FLNB):c.4804T> ['CTACGGGGGTGACGACATCCCACTTYCTCCT

1698 C (p.Serl602Pro) 2317 FLNB TATCGCATCCGAGCCACACA']

NM_002863.4(PYGL):c.2461T> ['CTCCAGTGACCGAACAATTAAAGAAYATGC

1699 C (p.Tyr821His) 5836 PYGL CCAAAACATCTGGAACGTGGA'] NM_003002.3(SDHD):c.284T>C ['CCTTGCTCTGCGATGGACTATTCCCYGGCTG

1700 (p.Leu95Pro) 6392 SDHD CAGCCCTCACTCTTCATGGT']

NM_004385.4(VCAN):c.4004- ['TAAGTATTGTGAAAACTCTGTTTTTHTCAGG

1701 5T>C 1462 VCAN TCGAATGAGTGATTTGAGTG']

NM_004519.3(KCNQ3):c.925T> ['TGAGACCTATGCAGATGCCCTGTGGYGGGG

1702 C (p.Trp309Arg) 3786 KCNQ3 CCTGGTGAGTCACTACCTTGG]

NM_004937.2(CTNS):c.473T>C ['TCCACCCCCTGCAGTGTCATTGGTCYGAGCT

1703 (p.Leul58Pro) 1497 CTNS TCGACTTCGTGGCTCTGAAC]

NM_006329.3(FBLN5):c.649T> ['GAACGAGTGTGCCACCGAGAACCCCYGCGT

1704 C (p.Cys217Arg) 10516 FBLN5 GCAAACCTGCGTCAACACCTA]

NM_006432.3(NPC2):c.295T>C ['TGATGGTTGTAAGAGTGGAATTAACYGCCCT

1705 (p.Cys99Arg) 10577 NPC2 ATCCAAAAAGACAAGACCTA]

NM_007375.3(TARDBP):c.*83T ['CATGGTAAGTATATTGTAAAATACAYATGTA

1706 >C 23435 TARDBP CTAAGAATTTTCAAAATTGG']

NM_013246.2(CLCFl):c.46T>C ['CTCGTGGGGGATGTTAGCGTGCCTGYGCAC

1707 (p.Cysl6Arg) -1 - GGTGCTCTGGCACCTCCCTGC]

NM_013246.2(CLCFl):c.676T> ['CCTGCACCTGGGGGCTCATGGCTTCYGACTT

1708 C (p.Ter226Arg) -1 - CTGACCTTCTCCTCTTCGCT']

NM_024577.3(SH3TC2):c.l982 ['CTGCCCTTTGCCGAGCGCCTGCAGCYCCTCT

1709 T>C (p.Leu661Pro) 79628 SH3TC2 CTGGACACCCTCCTGCCTCT']

NM_172107.2(KCNQ2):c.2T>C ['CCGGGGCGCCTCCCGCCAGGCACCAYGGTG

1710 (p.MetlThr) 3785 KCNQ2 CAGAAGTCGCGCAACGGCGGC]

M_004304.4(ALK):c.3749T>C ['TGCATTTCCTTTCTTCCCAGAGACAYTGCTG

1711 (p.Ilel250Thr) 238 ALK CCAGAAACTGCCTCTTGACC]

NM_000495.4(COL4A5):c.4690 ['TTCCTTCTCCTTTTCCTTTACCAGAYGTGCAG

1712 T>C (p.Cysl564Arg) 1287 COL4A5 TATGTGAAGCTCCAGCTGT']

NM_000495.4(COL4A5):c.4699 ['CTTTTCCTTTACCAGATGTGCAGTAYGTGAA

1713 T>C (p.Cysl567Arg) 1287 COL4A5 GCTCCAGCTGTGGTGATCGC]

NM_000495.4(COL4A5):c.4756 ['CAGTCAGACGATCCAGATTCCCCATYGTCCT

1714 T>C (p.Cysl586Arg) 1287 COL4A5 CAGGGATGGGATTCTCTGTG]

NM_000495.4(COL4A5):c.4803 ['TAAGAAGCTTAAACTTCAAACAGCTYCTATC

1715 +121T>C 1287 COL4A5 CAAGCACTGTGTTCCCCCTC]

NM_000495.4(COL4A5):c.5032 ['AGACTTGAGGACACGAATTAGCCGAYGTCA

1716 T>C (p.Cysl678Arg) 1287 COL4A5 AGTGTGCATGAAGAGGACATA']

NM_005359.5(SMAD4):c.970T> ['ATTTCCTATAGCTCCTGAGTATTGGYGTTCC

1717 C (p.Cys324Arg) 4089 SMAD4 ATTGCTTACTTTGAAATGGA']

NM_005359.5(SMAD4):c. l087T ['GGACCCTTCTGGAGGAGATCGCTTTYGTTTG

1718 >C (p.Cys363Arg) 4089 SMAD4 GGTCAACTCTCCAATGTCCA']

NM_005359.5(SMAD4):c. l598T ['ATTGAAATTCACTTACACCGGGCCCBCCAGC

1719 >C (p.Leu533Pro) 4089 SMAD4 TCCTAGACGAAGTACTTCAT']

NM_020630.4(RET):c.l831T>C ['TAAAGCTGGCTATGGCACCTGCAACNGCTTC

1720 (p.Cys611Arg) 5979 RET CCTGAGGAGGAGAAGTGCTT']

NM_020630.4(RET):c.l888T>C ['ACCACCCCCACCCACAGATCCACTGYGCGA

1721 (p.Cys630Arg) 5979 RET CGAGCTGTGCCGCACGGTGAT'] NM_000060.3(BTD):c.248T>C ['GCTCTCATCAGCCGCCAAGAGGCCTYGGAG

1722 (p.Leu83Ser) 686 BTD CTCATGAACCAGAACCTTGAC]

NM_000060.3(BTD):c.445T>C ['GAACCCATGCCTGGAGCCTCACCGCYTCAAT

1723 (p.Phel49Leu) 686 BTD GACACAGAGGTGATTCCTGC]

NM_000060.3(BTD):c.743T>C ['TTTGGCATCTTCACATGCTTTGATAYATTGTT

1724 (p.Ile248Thr) 686 BTD CTTTGACCCTGCCATCAGA']

NM_000060.3 (BTD) : c.764T>C ['GATATATTGTTCTTTGACCCTGCCAYCAGAG

1725 (p.Ile255Thr) 686 BTD TCCTCAGAGACTACAAGGTG]

NM_000060.3(BTD):c.833T>C ['ACTGCCTGGATGAACCAGCTCCCACYCTTGG

1726 (p.Leu278Pro) 686 BTD CAGCAATTGAGATTCAGAAA']

NM_000060.3(BTD):c. l096T>C ['CCATAGTAAGTTTTTAAAAATTTTGYCAGGC

1727 (p.Ser366Pro) 686 BTD GATCCGTACTGTGAGAAGGA']

NM_000060.3(BTD):c. l214T>C ['GAGATGATGTATGACAATTTCACCCYGGTCC

1728 (p.Leu405Pro) 686 BTD CTGTCTGGGGAAAGGAAGGC]

NM_000060.3(BTD):c. l252T>C ['GGGAAAGGAAGGCTATCTCCACGTCYGTTC

1729 (p.Cys418Arg) 686 BTD CAATGGCCTCTGCTGTTATTT']

NM_000060.3(BTD):c. l267T>C ['TCTCCACGTCTGTTCCAATGGCCTCYGCTGT

1730 (p.Cys423Arg) 686 BTD TATTTACTTTACGAGAGGCC]

NM_000060.3(BTD):c. l459T>C ['CACGGGGATATTTGAGTTTCACCTGYGGGGC

1731 (p.Trp487Arg) 686 BTD AACTTCAGTACTTCCTATAT']

NM_000155.3(GALT):c.265T>C ['TCCTTGTCGGTAGGTGAATCCCCAGBACGAT

1732 (p.Tyr89His) 2592 GALT AGCACCTTCCTGTTTGACAA']

NM_000155.3(GALT):c.328+2T ['TGCAGCCTGATGCCCCCAGTCCAGGYAACCT

1733 >C 2592 GALT GGCTCCAACTGCTGCTGGGG]

NM_000155.3(GALT):c.336T>C ['GATACTCCTTTACCTCAGGACCCAGYGATCA

1734 (p.Serl l2=) 2592 GALT TCCCCTTTTCCAAGCAAAGT']

NM_000155.3(GALT):c.350T>C ['TCAGGACCCAGTGATCATCCCCTTTYCCAAG

1735 (p.Phel l7Ser) 2592 GALT CAAAGTCTGCTCGAGGAGTC]

NM_000155.3 (GALT) :c .374T>C ['TTCCAAGCAAAGTCTGCTCGAGGAGYCTGG

1736 (p.Vall25Ala) 2592 GALT TAACTATGGATTTCCCCTCTT']

NM_000155.3(GALT):c.425T>C ['TGGTCGGATGTAACGCTGCCACTCAHGTCGG

1737 (p.Metl42Thr) 2592 GALT TCCCTGAGATCCGGGCTGTT']

NM_000155.3(GALT):c.452T>C ['TCGGTCCCTGAGATCCGGGCTGTTGYTGATG

1738 (p.Vall51Ala) 2592 GALT CATGGGCCTCAGTCACAGAG]

NM_000155.3(GALT):c.460T>C ['TGAGATCCGGGCTGTTGTTGATGCABGGGCC

1739 (p.Trpl54Arg) 2592 GALT TCAGTCACAGAGGAGCTGGG]

NM_000155.3(GALT):c.482T>C ['GCATGGGCCTCAGTCACAGAGGAGCYGGGT

1740 (p.Leul61Pro) 2592 GALT GCCCAGTACCCTTGGGTGCAG]

NM_000155.3(GALT):c.499T>C ['AGAGGAGCTGGGTGCCCAGTACCCTYGGGT

1741 (p.Trpl67Arg) 2592 GALT GCAGGTTTGTGAGGTCGCCCC]

NM_000155.3(GALT):c.507+2T ['GGTGCCCAGTACCCTTGGGTGCAGGYTTGTG

1742 >C 2592 GALT AGGTCGCCCCTTCCCCTGGA']

NM_000155.3(GALT):c.509T>C ['GAGCTCCGTATCCCTATCTGATAGAHCTTTG

1743 (p.Ilel70Thr) 2592 GALT AAAACAAAGGTGCCATGATG] ΝΜ_000155.3 (GALT) :c .584T>C ['TGACAGGTATGGGCCAGCAGTTTCCYGCCA

1744 (p.Leul95Pro) 2592 GALT GATATTGCCCAGCGTGAGGAG]

NM_000155.3(GALT):c.650T>C ['TATAAGAGTCAGCATGGAGAGCCCCYGCTA

1745 (p.Leu217Pro) 2592 GALT ATGGAGTACAGCCGCCAGGAG]

NM_000155.3(GALT):c.677T>C ['CTAATGGAGTACAGCCGCCAGGAGCYACTC

1746 (p.Leu226Pro) 2592 GALT AGGAAGGTGGGAGAGAGCCAA']

NM_000155.3(GALT):c.687+2T ['AGCCGCCAGGAGCTACTCAGGAAGGYGGGA

1747 >C 2592 GALT GAGAGCCAAGCCCTGTGTCCC]

NM_000155.3(GALT):c.745T>C ['AGTACTGGTCCCCTTCTGGGCAACAYGGCCC

1748 (p.Trp249Arg) 2592 GALT TACCAGACACTGCTGCTGCC]

NM_000155.3 (GALT) :c .967T>C ['CCATTGGCAGCTGCACGCTCATTACBACCCT

1749 (p.Tyr323His) 2592 GALT CCGCTCCTGCGCTCTGCCAC]

NM_000155.3(GALT):c.980T>C ['CACGCTCATTACTACCCTCCGCTCCYGCGCT

1750 (p.Leu327Pro) 2592 GALT CTGCCACTGTCCGGAAATTC]

NM_000155.3 (GALT) :c.1138T> ['GGACAGGGAGACAGCAACCATCGCCYGACC

1751 C (p.Ter380Arg) 2592 GALT ACGCCGACCACAGGGCCTTGA']

NM_207346.2(TSEN54):c.277T 28398 ['AGAAGAGGGCTTCGTGGAGTTGAAGYCTCC

1752 >C (p.Ser93Pro) 9 TSEN54 CGCGGTGAGCGGCGGGCTCGG]

NM_016269.4(LEFl):c.l81T>C ['CATCAAGTCTTCCTTGGTGAACGAGYCTGAA

1753 (p.Ser61Pro) -1 - ATCATCCCGGCCAGCAACGG]

NM_001928.2(CFD) : c.640T>C ['GGGTGACTCCGGGGGCCCGCTGGTGYGCGG

1754 (p.Cys214Arg) 1675 CFD GGGCGTGCTCGAGGGCGTGGT']

NM_001458.4(FLNC):c.752T>C ['CCCAACGTGGATGAGCATTCTGTTAYGACCT

1755 (p.Met251Thr) 2318 FLNC ACCTGTCCCAGTTCCCCAAG']

NM_000781.2(CYPl lAl):c.665 ['ATTTTTGGGGAGCGCCAGGGGATGCYGGAG

1756 T>C (p.Leu222Pro) 1583 CYP11A1 GAAGTAGTGAACCCCGAGGCC]

['ATAATAATGATGGTTGccaacatgcgctgagtgcttaaaa tgtgccaggta',

'ataaataggtaaagggctttagaattgtgcaccatactcacaaccaccctg'

'cgcagcagattctgttattaaaccccttttacagacgaagttgaggctcac', 'agagattatgtaactcactcaagacaacacagataaaagatgaaactgaat

1757

NM_000782.4(CYP24Al):c.l22 ACAAATTCTACTTACTCCTTTGGGTRAAGCAT 1761 6T>C (p.Leu409Ser) 1591 CYP24A1 ATTCACCCAGAACTGTTGC]

NM_001145661.1 (GAT A2) :c .11 ['CAACGGGGACCCTGTCTGCAACGCCYGTGG

1762 17T>C (p.Cys373Arg) 2624 GATA2 CCTCTACTACAAGCTGCACAA']

NM_004523.3(KIFl l):c.2547+2 ['CAGGAACTTCACAACTTATTGGAGGYAATA

1763 T>C 3832 KIF11 ACTTTGTAAGTGGAACTTACT']

NM_000238.3 (KCNH2) : c.1831 T ['GGGCGGCCCCTCCATCAAGGACAAGBATGT

1764 >C (p.Tyr611His) 3757 KCNH2 GACGGCGCTCTACTTCACCTT']

NM_002465.3(MYBPCl):c.706T ['GGAGGAAGAACCCCAGGTGGACGTAYGGGA

1765 >C (p.Trp236Arg) 4604 MYBPC1 GTTGCTGAAGAACGCGAAACC]

1766 NM_002465.3(MYBPCl):c2566 4604 MYBPC1 ['CATTCCAAGACACCTGAAGCAAACCYATAT T>C (p.Tyr856His) CCGCAGAGTTGGAGAAGCTGT']

NM_005211.3(CSFlR):c.2624T> ['AAACTGGTGAAGGATGGATACCAAAYGGCC

1767 C (p.Met875Thr) 1436 CSF1R CAGCCTGCATTTGCCCCAAAG]

NM_005211.3(CSFlR):c.2381T> [TTGACCAATGGTCATGTGGCCAAGAYTGGG

1768 C (p.Ile794Thr) 1436 CSF1R GACTTCGGGCTGGCTAGGGAC]

NM_003392.4(WNT5A):c.544T ['GCCGCGGGACTGGCTCTGGGGCGGCYGCGG

1769 >C (p.Cysl82Arg) 7474 WNT5A CGACAACATCGACTATGGCTA]

NM_005188.3(CBL):c. ll50T>C ['CTCCACATTCCAACTATGTAAAATABGTGCT

1770 (p.Cys384Arg) 867 CBL GAAAATGATAAGGATGTAAA]

NM_005188.3 (CBL) : c.1186T>C ['TGATAAGGATGTAAAGATTGAGCCCYGTGG

1771 (p.Cys396Arg) 867 CBL ACACCTCATGTGCACATCCTG]

NM_006902.4(PRRXl):c.338T> ['CAGCTGCAGGCTTTGGAGCGTGTCTYTGAGC

1772 C (p.Phel l3Ser) 5396 PRRX1 GGACACACTATCCTGATGCT']

NM_001111035.1(ACP5):c.602T ['GCGGCGGCCAGGGAGGACTACGTGCYGGTG

1773 >C (p.Leu201Pro) -1 - GCTGGCCACTACCCCGTGTGG]

NM_000329.2(RPE65):c.l l02T> ['GGCTCCCCAACCTGAAGTTAGGAGAYATGT

1774 C (p.Tyr368His) 6121 RPE65 ACTTCCTTTGAATATTGACAA']

NM_003172.3(SURFl):c.679T> ['TGAGAACAATCCAGAAAGGAACCACYGGCA

1775 C (p.Trp227Arg) 6834 SURF1 TTATCGAGACCTGGAAGCTAT']

NM_002734.4(PRKAR1 A):c.111 ['CATCCTCAAACGAAACATCCAGCAGYACAA

1776 7T>C (p.Tyr373His) 5573 PRKAR1A CAGTTTTGTGTCACTGTCTGT']

NM_002734.4(PRKARlA):c.980 ['CCATCTTTGCTTTCTCCAGGTGAAAYTGCAC

1777 T>C (p.Ile327Thr) 5573 PRKAR1A TACTGATGAATCGTCCTCGT']

NM_003491.3(NAA10):c.l09T> ['GAAATACTACTTCTACCATGGCCTTYCCTGG

1778 C (p.Ser37Pro) 8260 NAA10 CCCCAGGTGGGCAGCTTCTG]

NM_006306.3(SMClA):c.2351T ['GTGTTTGAAGAGTTTTGTCGGGAGAYTGGTG

1779 >C (p.Ile784Thr) 8243 SMC1A TGCGCAACATCCGGGAGTTT']

NM_000377.2(WAS):c.814T>C ['CGACCCAGATCTGCGGAGTCTGTTCYCCAGG

1780 (p.Ser272Pro) 7454 WAS GCAGGAATCAGCGAGGCCCA]

NM_000377.2(WAS):c.881T>C ['ACCTCTAAACTTATCTACGACTTCAYTGAGG

1781 (p.Ile294Thr) 7454 WAS ACCAGGGTGGGCTGGAGGCT']

['TTGGTGCAACTCCAAATAAAAGTAAYAACC

1782 m.l2338T>C 4540 MT-ND5 ATGCACACTACTATAACCACC]

[TCGAATTTGCAATTCAATATGAAAAYCACCT

1783 m.5814T>C 4511 MT-TC CGGAGCTGGTAAAAAGAGGC]

['GACAACAGAGGCTTACGACCCCTTAYTTACC

1784 m.l2201T>C 4564 MT-TH GAGAAAGCTCACAAGAACTG]

NM_001165899.1(PDE4D):c494 ['GGAGATGACTTGATTGTGACTCCATBTGCTC

1785 T>C (p.Phel65Ser) 5144 PDE4D AGGTAAGCACAGCTTGGTGA]

NM_139125.3(MASPl):c. l888T ['GTTACCCGTGGTGCCTCACGCTGAGYGCAA

1786 >C (p.Cys630Arg) 5648 MASP1 AACTAGCTATGAGTCCCGCTC]

NM_007315.3(STATl):c.520T> ['TTTACAAGATGAATATGACTTCAAAYGCAA

1787 C (p.Cysl74Arg) 6772 STAT1 AACCTTGCAGAACAGAGGTAA']

1788 NM_053025.3(MYLK):c.5275T> -1 - ['TGCTGTGAGAGCCATTGGAAGACTGYCCTCT C (p.Serl759Pro) ATGGCAATGATCTCAGGGCT']

NM_001235.3(SERPINHl):c.23 ['TCACCCGTGGTGGTGGCCTCGTCGCYAGGGC

1789 3T>C (p.Leu78Pro) 871 SERPINHl TCGTGTCGCTGGGCGGCAAG]

NM_005921.1(MAP3Kl):c.566T ['GAGGAACGAATGATCAGGGAGAAACBGAA

1790 >C (p.Leul89Pro) 4214 MAP3K1 GGCAACCTGTATGCCAGCCTGG]

NM_005359.5(SMAD4):c. l499T ['GTTGATGACCTTCGTCGCTTATGCAYACTCA

1791 >C (p.Ile500Thr) 4089 SMAD4 GGATGAGTTTTGTGAAAGGC]

NM_000287.3 (PEX6) : c.1601 T> ['CTGTTGCTCACAGCTGTGGACCTTCYGGGCC

1792 C (p.Leu534Pro) 5190 PEX6 GGGACCGTGATGGGCTGGGT']

NM_004153.3 (ORC 1 ) : c.266T>C ['AAGAAACGTGCTCGAGTACAGTGGTYTGTC

1793 (p.Phe89Ser) 4998 ORC1 CGATTCTGTGAAGTCCCTGCC]

NM_006225.3(PLCDl):c.562T> ['CTCGGCTGTCCTGGCTCTGCAGGAGYGTGAC

1794 C (p.Cysl88Arg) 5333 PLCD1 CACTCCCAGACAGACTCCCT']

NM_021252.4(RAB18):c.619T> ['CTGTGGTGGTTATTGCTCTGTGTTAYAAACT

1795 C (p.Ter207Gln) 22931 RAB18 CTGGGAAATTCCATCTCTTG]

NM_002242.4(KCNJ13):c.722T ['TGGTGTAATGGAGTGATAGTACGTTDGTGG

1796 >C (p.Leu241Pro) -1 - AAAGATGAAGAATGGACATTC]

NM_003072.3 (SMARC A4) :c .30 ['CTGCAGCGAGTGCTCTACCGCCACAYGCAG

1797 32T>C (p.MetlOHThr) 6597 SMARCA4 GCCAAGGGCGTGCTGCTGACT']

NM_013339.3(ALG6):c.391T>C ['GAGATTTCTTTTAAGCAACAACAGTRCAAAA

1798 (p.Tyrl31His) 29929 ALG6 CCACTGCAGGTATGTAAATC]

NM_019885.3(CYP26Bl):c.436 ['TTGCCTCTCTGCCTTCCAGGTCTTCYCCAAG

1799 T>C (p.Serl46Pro) 56603 CYP26B1 ATCTTCAGCCACGAGGCCCT']

NM_020433.4(JPH2):c.421T>C ['GTTCACCAACGGCATGCGCCATGGCYACGG

1800 (p.Tyrl41His) 57158 JPH2 AGTACGCCAGAGCGTGCCCTA]

NM_000199.3(SGSH):c.892T>C ['CCCCAGCGTTTTGGGTGCTCCGGGGRTGACA

1801 (p.Ser298Pro) 6448 SGSH CCAGTAAGGGTTCAGCAGTG]

NM_173170.1(IL36RN):c.80T> ['CTTTATCTGCATAATAACCAGCTTCYAGCTG

1802 C (p.Leu27Pro) 26525 IL36RN GAGGGCTGCATGCAGGGAAG]

NM_016599.4(MYOZ2):c.l42T> ['CAGAGACATCATGTTGGAAGAATTAYCCCA

1803 C (p.Ser48Pro) 51778 MYOZ2 TCTCAGTAACCGTGGTGCCAG]

NM_020191.2(MRPS22):c.644T ['CCAATAATTTTCAAGGAAGAAAATCYTAGG

1804 >C (p.Leu215Pro) 56945 MRPS22 GTAAGGTGACTTAGGTTTTAT']

NM_004278.3 (PIGL) :c .500T>C ['TTGTCCTATCCCTCCTCCAGGGCCCYGCACT

1805 (p.Leul67Pro) 9487 PIGL CAGAAGGGAAGTTACCTAAA]

NM_022445.3 (TPK1 ) : c.119T>C ['ATTTTGTTCTTTCTATTTGAAGCTCYTTTAAG

1806 (p.Leu40Pro) 27010 TPK1 AGCCTGTGCCGATGGAGGT']

NM_020634.1(GDF3):c.914T>C ['TGTCCCTTCTCACTGACCATCTCTCYCAACA

1807 (p.Leu305Pro) 9573 GDF3 GCTCCAATTATGCTTTCATG]

NM_017882.2(CLN6):c.200T>C ['CCCATTCTTCCATTTGCTCCGCAGCYGGTAT

1808 (p.Leu67Pro) 54982 CLN6 TCCCTCTCGAGTGGTTTCCA']

NM_024513.3(FYCOl):c.4127T ['TTTGTGAGGTCCAGCACCTACAGCCYGATCC

1809 >C (p.Leul376Pro) 79443 FYCOl CCATCACTGTGGCCGAGGCA']

1810 NM_006147.3(IRF6):c.65T>C 3664 IRF6 ['CTGGTGGCCCAGGTGGATAGTGGCCYCTAC (p.Leu22Pro) CCTGGGCTCATCTGGCTACAC]

NM_025132.3(WDR19):c.2129T ['GGAAATGTTGGCATAGTGATGTCCTYGGAA

1811 >C (p.Leu710Ser) 57728 WDR19 CAAATAAAGGTAAACAGCATG]

NM_025132.3(WDR19):c.20T> ['TTTATTTTTTAGCGTATTTTCTCACYGCTAGA

1812 C (p.Leu7Pro) 57728 WDR19 AAAGACTTGGCTTGGCGCA']

NM_153026.2(PRICKLEl):c.14 14416 ['AAGTAAAAAATACCAGTCTGATATGYACTG

1813 14T>C (p.Tyr472His) 5 PRICKLE 1 GGCACAGTCACAAGATGGACT']

M_014874.3 (MFN2) :c .1392+2 ['GTAGTCCTCAAGGTTTATAAGAATGWGAGT

1814 T>C 9927 MFN2 CATGGAGCAACAGGTCCTCTT']

M_014874.3(MFN2):c.647T>C ['GAGCTGGACAGCTGGATTGACAAGTYTTGT

1815 (p.Phe216Ser) 9927 MFN2 CTGGATGCTGATGTGTTTGTG]

NM_016097.4(IER3IPl):c.233T ['GTAAACTCAATTGCAATTGTGTTACYTTTAT

1816 >C (p.Leu78Pro) 51124 IER3IP1 TATTTGGATGAATATCAGTG]

NM_018718.2(CEP41):c.l07T> ['TTCGAGCTTCTCAGTATATTTAGTCRTACTGT

1817 C (p.Met36Thr) 95681 CEP41 TACCTAAAAAGAAAATAAG]

NM_022489.3(INF2):c.310T>C ['CCTGCTGCAGCTCACCTGCGTCAGCYGCGTG

1818 (p.Cysl04Arg) 64423 INF2 CGCGCCGTCATGAACTCGCG]

NM_022489.3 (INF2) :c .383 T>C ['AGCAACCAGGGCTACGTGCGCCAGCYCTCC

1819 (p.Leul28Pro) 64423 INF2 CAGGGTGAGCCGCAGTGTGGG]

NM_018713.2(SLC30A10):c.266 ['GGCGCGCTGAGCAACGCGGTCTTCCYCACC

1820 T>C (p.Leu89Pro) 55532 SLC30A10 GCGCTCTGCTTCACCATCTTC]

NM_058246.3(DNAJB6):c.277T ['CAGTCCATTTGAATTTGGCTTCACAYTCCGT

1821 >C (p.Phe93Leu) 10049 DNAJB6 AACCCAGATGATGTCTTCAG]

NM_024753.4(TTC21B):c.2384 ['CAAAAGAATTATCTTTGCTATGACCYGGCTG

1822 T>C (p.Leu795Pro) 79809 TTC21B AGCTCTTATTAAAATTGAAA']

NM_032446.2(MEGF10):c.2320 ['TGACTGCGACCACATTTCTGGGCAGYGTACT

1823 T>C (p.Cys774Arg) 84466 MEGF10 TGCCGCACTGGATTCATGGG']

NM_032446.2(MEGF10):c.976T ['CGTTCTCTGTGCTGAGACCTGCCAGYGTGTC

1824 >C (p.Cys326Arg) 84466 MEGF10 AACGGAGGGAAGTGTTACCA']

NM_024027.4(COLECll):c.505 ['GAAGCGCTACGCGGACGCCCAGCTGYCCTG

1825 T>C (p.Serl69Pro) 78989 COLEC11 CCAGGGCCGCGGGGGCACGCT']

NM_000035.3(ALDOB):c.l027T ['GCCCCAGAAGAACCCGTGTGAACATRCTGT

1826 >C (p.Tyr343His) 229 ALDOB CCTTTGGCCGCCTGGCAGTTA']

NM_012338.3(TSPAN12):c.734 ['CCTTCTATCATAATACAGAGCCCAGRGCAGA

1827 T>C (p.Leu245Pro) 23554 TSPAN12 GTAATGGTGAGAATCATGGC]

NM_001159772.1(CANTl):c.67 12458 ['CTCCTTGCCCAGGCCGCCCACGTACRGACGC

1828 1T>C (p.Leu224Pro) 3 CANT1 TCGTCCTTCACTGCCAGCCA']

NM_001006657.1(WDR35):c.78 ['TGGCATGTACGTAGTAGGCATCCAGYGGAA

1829 1T>C (p.Trp261Arg) 57539 WDR35 CCACATGGGCAGCGTGTTAGC]

NM_000420.2(KEL):c.1790T>C ['TCAACAGTACTGCCTGGGGGCTGCCYCGCCT

1830 (p.Leu597Pro) 3792 KEL GTGACAACCATGCCCTCCAG]

NM_001243473.1(B9Dl):c.400+ ['AGGGCCCAGGTCAGAATGAGGACCTRCCGG

1831 2T>C 27077 B9D1 CCAGGTGAGAAGGGCACGTGC]

1832 NM_015175.2(NBEAL2):c.l l63 23218 NBEAL2 ['ATTGCAGTCCATGTAGTCAGAGTGCYGACCT T>C (p.Leu388Pro) GCATCATGAGTGACTCCCCC']

NM_000196.3(HSDl lB2):c.l01 ['GCTGGCAGCTCGGCCCCGCCGCCGCYATTAC

1833 2T>C (p.Tyr338His) 3291 HSD11B2 CCCGGCCAGGGCCTGGGGCT']

NM_024599.5(RHBDF2):c.557T ['GCTTACCGCCCCCCTCCCTTCCAGAYTGTGG

1834 >C (p.Ilel86Thr) 79651 RHBDF2 ATCCGCTGGCCCGGGGCCGG]

NM_001256714.1(DNAAF3):c.3 35290 ['GGCTCTGTGGATGGACGGCACCTGCYGCGG

1835 86T>C (p.Leul29Pro) 9 DNAAF3 ACCCTGTCCCGAGCGAAGTTC]

NM_020894.2(UVSSA):c.94T>C ['GAAAATGAAGGAACTGAAGAAAATTYGCAA

1836 (p.Cys32Arg) 57654 UVSSA GTATGTCTTAGGGTTCAGTAA']

NM_004453.3 (ETFDH) :c.1130T ['TTGTTTCCTCAGTCTATACCAAAACYCACCT

1837 >C (p.Leu377Pro) 2110 ETFDH TTCCTGGTGGTTTACTAATT']

NM_024306.4(FA2H):c.707T>C ['CTCATCGAGTACCTCATCCACCGCTYCCTGT

1838 (p.Phe236Ser) 79152 FA2H TCCACATGAAGCCCCCCAGC]

NM_001004127.2(ALGl l):c.l l4 ['AAAATAAACATTCCATTTGATGAATYAAAG

1839 2T>C (p.Leu381Ser) -1 - AATTATTTGTCTGAAGCAACA]

NM_021167.4(GATADl):c.304T ['TCGGCTCAGAAACACTAAATACAAAYCTGC

1840 >C (p.Serl02Pro) 57798 GAT AD 1 TCCGGCTGCTGAAAAGAAAGT']

NM_016042.3(EXOSC3):c.712T ['AGTATTTGGAATGAATGGAAGAATAYGGGT

1841 >C (p.Trp238Arg) 51010 EXOSC3 TAAGGCAAAAACCATCCAGCA']

NM_001018005.1(TPMl):c.515 ['CAGGTGGCCCGTAAGCTGGTCATCAYTGAG

1842 T>C (p.Ilel72Thr) 7168 TPM1 AGCGACCTGGAACGTGCAGAG]

NM_001018005.1(TPMl):c.842 ['GAGCTGGACCACGCTCTCAACGATAYGACT

1843 T>C (p.Met281Thr) 7168 TPM1 TCCATGTAAACGTTCATCCAC]

NM_033360.3(KRAS):c.211T>C ['GGAGTACAGTGCAATGAGGGACCAGYACAT

1844 (p.Tyr71His) 3845 KRAS GAGGACTGGGGAGGGCTTTCT']

NM_006218.2(PIK3CA):c. l258T ['TTTTTCTTTGTTTTTTAAGGAACACYGTCCAT

1845 >C (p.Cys420Arg) 5290 PIK3CA TGGCATGGGGAAATATAAA']

NM_006265.2(RAD21):c.l753T ['TGAATCTATCAGTTTGCTTGAGTTAYGTCGA

1846 >C (p.Cys585Arg) -1 - AATACGAACAGAAAACAAGC]

NM_000222.2(KIT):c.l859T>C ['ATTAAGTCAGATGCGGCCATGACTGYCGCT

1847 (p.Val620Ala) 3815 KIT GTAAAGATGCTCAAGCGTAAG]

NM_000076.2(CDKNlC):c.827T ['CGCGCGCTGTCGCCCGCAGATTTCTYCGCCA

1848 >C (p.Phe276Ser) 1028 CDKN1C AGCGCAAGAGATCAGCGCCT']

NM_005691.3(ABCC9):c.3058T ['AGACTATTGGCTGGCCACATGGACAYCGGA

1849 >C (p.Serl020Pro) 10060 ABCC9 GTACAGTATAAACAATACTGG]

NM_012343.3(NNT):c.2930T>C ['ATGCCTGGTCAGCTTAATGTGCTGCYGGCTG

1850 (p.Leu977Pro) 23530 NNT AGGCTGGTGTGCCATATGAC]

NM_024110.4(CARD14):c.467T ['GTGCTGCTGCGGCGGTGCCAGCAGCYGCAG

1851 >C (p.Leul56Pro) 79092 CARD14 GAGCACCTGGGCCTGGCCGAG]

NM_000492.3 (CFTR) :c .1400T> ['GATGGGTTTTATTTCCAGACTTCACYTCTAA

1852 C (p.Leu467Pro) 1080 CFTR TGGTGATTATGGGAGAACTG]

NM_000518.4(HBB):c.2T>C ['CACTAGCAACCTCAAACAGACACCANGGTG

1853 (p.MetlThr) 3043 HBB CATCTGACTCCTGAGGAGAAG]

1854 NM_000518.4(HBB):c.*110T>C 3043 HBB ['CCTTGAGCATCTGGATTCTGCCTAAHAAAAA ACATTTATTTTCATTGCAAT']

['AGTTGGTGGTGAGGCCCTGGGCAGGNTGGT

1855 NM_000518.4(HBB):c.92+2T>C 3043 HBB ATCAAGGTTACAAGACAGGTT']

NM_000206.2(IL2RG):c.455T> ['ACCACATATGCACACATATCTCCAGYGATCC

1856 C (p.Vall52Ala) 3561 IL2RG CCTGGGCTCCAGAGAACCTA']

NM_000244.3 (MENl ) :c .518T>C ['GCTGTGGTTGGGGCCTGCCAGGCCCYGGGT

1857 (p.Leul73Pro) 4221 MENl CTCCGGGATGTCCACCTCGCC]

NM_000256.3(MYBPC3):c.2374 ['CCGCCATCGTAGGCAGGCGGCTCCCVCTGTA

1858 T>C (p.Trp792Arg) 4607 MYBPC3 CTGTGCAGGAGTCCTCTCCC]

NM_002501.3(NFIX):c.l79T>C ['GAGGAGCGGGCGGTGAAGGACGAGCYGCTG

1859 (p.Leu60Pro) 4784 NFIX GGCGAGAAGCCCGAGATCAAG]

NM_005022.3(PFNl):c.341T>C ['CCTCCTCCAGCGCTAGTCCTGCTGAYGGGCA

1860 (p.Metll4Thr) 5216 PFN1 AAGAAGGTGTCCACGGTGGT']

NM_001172567.1(MYD88):c.81 ['CTTGCAGGTGCCCATCAGAAGCGACYGATC

1861 8T>C (p.Leu273Pro) 4615 MYD88 CCCATCAAGTACAAGGCAATG]

NM_001161581.1(POClA):c.39 ['GCCAGTGATGACAAGACTGTTAAGCYGTGG

1862 8T>C (p.Leul33Pro) 25886 POC1A GACAAGAGCAGCCGGGAATGT']

NM_005270.4(GLI2):c.4663T>C ['CCCCCGAAACTCCTTGACCCTGCCCYCCATC

1863 (p.Serl555Pro) 2736 GLI2 CCCGCAGGCATCAGCAACAT']

NM_152296.4(ATPlA3):c.2431 ['CTCCTCCGCCTAGGTCCCTGCCATCYCACTG

1864 T>C (p.Ser811Pro) 478 ATP 1 A3 GCGTACGAGGCTGCCGAAAG]

NM_022787.3(NMNATl):c.838 ['GAGAAACACTGCAGAAGCTAAGACAYAGGA

1865 T>C (p.Ter280Gln) 64802 NMNAT1 ATTCTACAGCATGATATTTCA']

NM_005340.6(HINTl):c.250T> ['ACACTTAATGATTGTTGGCAAGAAAYGTGCT

1866 C (p.Cys84Arg) 3094 HINT1 GCTGATCTGGGCCTGAATAA']

NM_000155.3(GALT):c.416T>C ['TTCCACCCCTGGTCGGATGTAACGCYGCCAC

1867 (p.Leul39Pro) 2592 GALT TCATGTCGGTCCCTGAGATC]

NM_000155.3 (GALT) :c .386T>C ['CTCCCGTCACCACCCAGTAAGGTCAYGTGCT

1868 (p.Metl29Thr) 2592 GALT TCCACCCCTGGTCGGATGTA']

NM_000155.3(GALT):c.680T>C ['ATGGAGTACAGCCGCCAGGAGCTACYCAGG

1869 (p.Leu227Pro) 2592 GALT AAGGTGGGAGAGAGCCAAGCC]

NM_007294.3(BRCAl):c.4986+ ['GCCTGACCCCAGAAGAATTTGTGAGBGTATC

1870 6T>C 672 BRCA1 CATATGTATCTCCCTAATGA']

NM_007294.3(BRCAl):c.5074+ ['CTACTCATGTTGTTATGAAAACAGGYATACC

1871 2T>C 672 BRCA1 AAGAACCTTTACAGAATACC]

NM_007294.3(BRCAl):c.5207T ['GGTTTCTTTCAGCATGATTTTGAAGBCAGAG

1872 >C (p.Vall736Ala) 672 BRCA1 GAGATGTGGTCAATGGAAGA']

NM_002437.4(MPV17):c.186+2 ['TGAAGCCCTGTTGAGGGGAGAACTTRCCAC

1873 T>C 4358 MPV17 AAAGCCACAGCCCAGGGACAC]

NM_002769.4(PRS S 1 ) :c .116T> ['GAGGAGAATTCTGTCCCCTACCAGGYGTCCC

1874 C (p.Val39Ala) -1 - TGAATTCTGGCTACCACTTC]

NM_004211.3(SLC6A5):c. l444 ['GATTTTCTTCTCTTTATCTGCTGCAYGGGGA

1875 T>C (p.Trp482Arg) 9152 SLC6A5 GGCCTGATCACTCTCTCTTC]

1876 NM_005211.3(CSFlR):c.2297T> 1436 CSF1R ['TTCTCCAGCCAAGTAGCCCAGGGCAYGGCC C (p.Met766Thr) TTCCTCGCTTCCAAGAATGTG]

NM_005211.3(CSFlR):c.2546T> ['TATGGCATCCTCCTCTGGGAGATCTYCTCAC

1877 C (p.Phe849Ser) 1436 CSF1R TTGGTGAGCCACTGGGCCCA']

NM_005211.3(CSFlR):c.2603T> ['CTGGTGAACAGCAAGTTCTATAAACBGGTG

1878 C (p.Leu868Pro) 1436 CSF1R AAGGATGGATACCAAATGGCC]

NM_006796.2(AFG3L2):c. l997 ['ATTTTTCAGATTGTTCAGTTTGGCABGAATG

1879 T>C (p.Met666Thr) 10939 AFG3L2 AAAAGGTTGGGCAAATCTCC]

NM_018713.2(SLC30A10):c. l04 ['GTAAGTGGAAAGATTATTGCCACCCYGCAC

1880 6T>C (p.Leu349Pro) 55532 SLC30A10 ATCAAGTATCCTAAGGACAGG]

NM_018713.2(SLC30A10):c.500 ['GCGGAGGGCTGTGTCCCCGGCGCTTYCGGG

1881 T>C (p.Phel67Ser) 55532 SLC30A10 GGGCCTCAGGGCGCGGAGGAC]

NM_000060.3 (BTD) : c.212T>C ['TATGAGCATCCATCCATCCTGAGTCYGAACC

1882 (p.Leu71Pro) 686 BTD CTCTGGCTCTCATCAGCCGC]

NM_000495.4(COL4A5):c.438+ ['TTTCCTGGTTTACAGGGTCCTCCAGYAAGTT

1883 2T>C 1287 COL4A5 ATAAAATTTGGGATTATGAT']

NM_000282.3(PCCA):c.491T>C ['CAGGCAGCAGAAGATGTCGTTTTCAYTGGA

1884 (p.Ilel64Thr) 5095 PCCA CCTGACACACATGCTATTCAA']

NM_000532.4(PCCB):c.1556T> ['ACACGTGCCCGAATCTGCTGTGACCYGGAT

1885 C (p.Leu519Pro) 5096 PCCB GTCTTGGCCAGCAAGAAGGTA]

NM_001099274.1(TINF2):c.860 ['CATAAGGAGCGCCCCACAGTCATGCYGTTTC

1886 T>C (p.Leu287Pro) 26277 TINF2 CCTTTAGGAATCTCGGCTCA']

NM_001099274.1(TINF2):c.862 ['TAAGGAGCGCCCCACAGTCATGCTGYTTCCC

1887 T>C (p.Phe288Leu) 26277 TINF2 TTTAGGAATCTCGGCTCACC]

NM_001363.4(DKCl):c. l049T> ['TCAATGCCTGTAGCTATTGCATTAAYGACCA

1888 C (p.Met350Thr) 1736 DKC1 CAGCGGTCATCTCTACCTGC]

NM_001363.4(DKCl):c. ll93T> ['AAGCTGATGATCAAGCAGGGCCTTCYGGAC

1889 C (p.Leu398Pro) 1736 DKC1 AAGCATGGGAAGCCCACAGAC]

M_004614.4(TK2):c.l56+2T> ['CAGGAAAAAGAGAAAAAATCAGTGGYAAG

1890 C 7084 TK2 TCCCTCTTTTATGTGTACTCTC']

M_004614.4(TK2):c.644T>C ['GAATACCTGGAAGCAATTCACCATCYCCAT

1891 (p.Leu215Pro) 7084 TK2 GAGGAGTGGCTCATCAAAGGC]

NM_024312.4(GNPTAB):c.l208 ['ATCGAAGGGCTGTCCCAGAAGTTTAYTTACC

1892 T>C (p.Ile403Thr) 79158 GNPTAB TAAATGATGATGTCATGTTT']

NM_024312.4(GNPTAB):c.3002 ['TTTGCCTTCTCTTATTTTTATTATCYCATGAG

1893 T>C (p.LeulOOlPro) 79158 GNPTAB TGCAGTGCAGCCACTGAAT']

NM_198253.2(TERT):c.3043T> ['CCGCCATCCTCTCAGGTTTCACGCAYGTGTG

1894 C (p.Cysl015Arg) 7015 TERT CTGCAGCTCCCATTTCATCA']

NM_207352.3 (CYP4V2) : c.1021 28544 ['TACAACTGCAGCTGCAATAAACTGGYCCTTA

1895 T>C (p.Ser341Pro) 0 CYP4V2 TACCTGTTGGGTTCTAACCC']

NM_207352.3(CYP4V2):c.655T 28544 ['TGCTCAAAGTAATGATGATTCCGAGYATGTC

1896 >C (p.Tyr219His) 0 CYP4V2 CGTGCAGTTTATAGGTAAAT']

NM_000335.4(SCN5A):c.5504T ['GCCAAGCCCAACCAGATAAGCCTCAYCAAC

1897 >C (p.Ilel835Thr) 6331 SCN5A ATGGACCTGCCCATGGTGAGT']

1898 NM_001111.4(ADAR):c.2615T> 103 ADAR ['CTCGGCCGCAAGATTCTGGCCGCCAYCATTA C (p.Ile872Thr) TGAAAAAAGACTCTGAGGAC]

NM_004281.3(BAG3):c.l385T> ['ATCGAAGAGTATTTGACCAAAGAGCYGCTG

1899 C (p.Leu462Pro) 9531 BAG3 GCCCTGGATTCAGTGGACCCC]

NM_183075.2(CYP2Ul):c.784T 11361 ['TTTTATGTCACGAGGCCTAGAAATCYGTCTG

1900 >C (p.Cys262Arg) 2 CYP2U1 AACAGTCAAGTCCTCCTGGT']

NM_006177.3 (NRL) : c.287T>C ['TTGGGGCTGAGTCCTGAAGAGGCCAYGGAG

1901 (p.Met96Thr) 4901 NRL CTGCTGCAGGGTCAGGGCCCA']

M_000344.3(SMNl):c.388T>C ['AACCTGTGTTGTGGTTTACACTGGAYATGGA

1902 (p.Tyrl30His) 6606 SMN1 AATAGAGAGGAGCAAAATCT']

NM_152692.4(C1GALT1C1):C.5 C1GALT1 ['AGGAGGAATTGTCTTAAGTGTAGAAYCAAT

1903 77T>C (p.Serl93Pro) 29071 CI GAAAAGACTTAACAGCCTTCT']

NM_024531.4(SLC52A2):c.368 ['TTAGCACTGGCCTTTGTGCTGGCACYGGCAT

1904 T>C (p.Leul23Pro) 79581 SLC52A2 GCTGTGCCTCGAATGTCACT']

NM_001253816.1(SLC52A2):c.l ['GCTCACTGCAGGTCCTTGGCAGGGCYGGGC

1905 016T>C (p.Leu339Pro) 79581 SLC52A2 GGCCTCTCTCTGCTGGGCGTG]

NM_002609.3(PDGFRB):c.l973 ['TCGGAGCTGAAGATCATGAGTCACCYTGGG

1906 T>C (p.Leu658Pro) 5159 PDGFRB CCCCACCTGAACGTGGTCAAC]

NM_020822.2(KCNTl):c.2386T ['CAACAGCTATGAAGACGCCAAGGCCYACGG

1907 >C (p.Tyr796His) 57582 KCNT1 GTTCAAGAACAAGCTGATCAT']

NM_001369.2(DNAH5):c. l l21T ['ACTATAGATCATTTTAATTGCATTTRTAAGT

1908 >C (p.Ile374Thr) 1767 DNAH5 GTAGGAATAGCATCCATCAT']

NM_017802.3(DNAAF5):c.2384 ['GTCCAGTACCTGTACCGAGAGTTGCYGGTTC

1909 T>C (p.Leu795Pro) 54919 DNAAF5 ACCTTGACGATCCAGAGAGG]

NM_006383.3 (CIB2) :c.272T>C ['GAGGGGAACCTCACTTTCAACGACTYTGTG

1910 (p.Phe91Ser) 10518 CIB2 GACATGTTTTCCGTGCTCTGC]

NM_006383.3(CIB2):c.368T>C ['ACAGACTTCAACACTGACAACTTCAYCTGCA

1911 (p.Ilel23Thr) 10518 CIB2 AGGAGGACCTGGAGCTGACG]

NM_005334.2(HCFCl):c.- ['TTAGTTGTTACTTCTTCACACAAGAYGGCGG

1912 970T>C 3054 HCFC1 CTCCCAGGGAGGAGGCATGA']

NM_178012.4(TUBB2B):c.350T 34773 ['GGAGCCGAGCTGGTCGACTCGGTCCYGGAT

1913 >C (p.Leul l7Pro) 3 TUBB2B GTGGTGAGGAAGGAGTCAGAG]

NM_000431.3(MVK):c.764T>C ['GTGGCTGGCGTCAGAAACAGGCTGCYCAAG

1914 (p.Leu255Pro) 4598 MVK GTGACTCTTGTTCCCTTCTTG]

NM_000431.3 (MVK) :c .122T>C ['TTGAACTTGAGAACATTCCTCCGGCYTCAAC

1915 (p.Leu41Pro) 4598 MVK CCCACAGCAATGGGAAAGTG]

NM_000431.3 (MVK) :c.1039+2T ['GTGGCATCACACTCCTCAAGCCAGGYATCCC

1916 >C 4598 MVK GGGGGTAGGTGGGCCAGGCT']

NM_000431.3 (MVK) :c.1094T> ['AAGCAGGCCCTGACCAGCTGTGGCTYTGAC

1917 C (p.Phe365Ser) 4598 MVK TGCTTGGAAACCAGCATCGGT']

NM_004055.4(CAPN5):c.731T> ['ACAGCAGCTGACATGGAGGCCCGCCYGGCG

1918 C (p.Leu244Pro) 726 CAPN5 TGCGGCCTGGTAAAGGGCCAC]

NM_133497.3(KCNV2):c.491T> 16952 ['GCCGTCTTCCAGCTGGTCTACAATTYCTACC

1919 C (p.Phel64Ser) 2 KCNV2 TGTCCGGGGTGCTGCTGGTG']

1920 NM_006567.3(FARS2):c.986T> 10667 FARS2 ['ATGATCCTCTACGACATCCCTGATAYCCGTC C (p.Ile329Thr) TCTTCTGGTGTGAGGACGAG']

NM_020376.3(PNPLA2):c.757+ ['GCCTGCGCTTTCTGCAGCGGAACGGYGCGC

1921 2T>C 57104 PNPLA2 GGACCCGGGCGGGAGAGGGCG]

M_018344.5(SLC29A3):c.607 ['TATGAGGAACTCCCAGGCACTGATAYCAGG

1922 T>C (p.Ser203Pro) 55315 SLC29A3 TGAGAGCCAGGGTCCGGGCAG]

NM_012275.2(IL36RN):c. ll5+6 ['TGCAGGGAAGGTCATTAAAGGTTGGYGATG

1923 T>C 26525 IL36RN AAACATGACCCACTTTCCTTG]

['TTCACACTTCTAGTAAGCCTCTACCYGCACG

1924 m.9191T>C 4508 MT-ATP6 ACAACACATAATGACCCACC]

NM_000108.4(DLD) : c.140T>C ['GTAGTTGATGCTGATGTAACAGTTAYAGGTT

1925 (p.Ile47Thr) 1738 DLD CTGGTCCTGGAGGATATGTT']

NM_000080.3(CHRNE):c.223T> ['AGAGGAGACTCTCACCACTAGCGTCYGGAT

1926 C (p.Trp75Arg) -1 - TGGAATCGTGAGTCAAATCTG]

NM_004376.5(COX15):c.l030T ['TGCCATTACAGTGCTCTACTTCCTCBCTCGG

1927 >C (p.Ser344Pro) 1355 COX15 AGAATTCCCCTTCCTAGAAG']

NM_004333.4(BRAF):c. l403T> ['GGACAAAGAATTGGATCTGGATCATYTGGA

1928 C (p.Phe468Ser) 673 BRAF ACAGTCTACAAGGGAAAGTGG]

NM_004333.4(BRAF):c. l454T> [TTAGGTGATGTGGCAGTGAAAATGTYGAAT

1929 C (p.Leu485Ser) 673 BRAF GTGACAGCACCTACACCTCAG]

NM_005188.3(CBL):c. l201T>C ['GATTGAGCCCTGTGGACACCTCATGYGCAC

1930 (p.Cys401Arg) 867 CBL ATCCTGTCTTACATCCTGGCA']

NM_002834.3(PTPNll):c.211T> ['CTATGACCTGTATGGAGGGGAGAAABTTGC

1931 C (p.Phe71Leu) 5781 PTPN11 CACTTTGGCTGAGTTGGTCCA']

NM_002834.3(PTPNll):c.853T> ['AAATAGATATAAAAACATCCTGCCCBGTAA

1932 C (p.Phe285Leu) 5781 PTPN11 GTATCAATATTCCGCTCAGTA']

NM_002880.3(RAFl):c.769T>C ['AGGTTCCCTCTCCCAGAGGCAGAGGYCGAC

1933 (p.Ser257Pro) 5894 RAF1 ATCCACACCTAATGTCCACAT']

NM_002880.3(RAFl):c.l423T> ['AGTCCTTAACAAGCATTGAGATATAYTTCTC

1934 C (p.Phe475Leu) 5894 RAF1 CATGAAGGCTTAACAGTGAA']

NM_005633.3(SOSl):c.806T>C ['GGCC ATATAGAAGATACAGTAGAAAB GAC A

1935 (p.Met269Thr) 6654 SOS1 GATGAAGGCAGTCCCCATCCA']

NM_005633.3(SOSl):c.l649T> ['ATATCTTTACAGTACCGGAGTACACYGGAA

1936 C (p.Leu550Pro) 6654 SOS1 AGGATGCTTGATGTAACAATG]

NM_005633.3(SOSl):c.2104T> ['TCGGCACTGGGTAGAGCACCACTTCYATGAT

1937 C (p.Tyr702His) 6654 SOS1 TTTGAAAGAGATGCATATCT']

NM_002755.3(MAP2Kl):c.388T ['CAACTCTCCGTACATCGTGGGCTTCYATGGT

1938 >C (p.Tyrl30His) 5604 MAP2K1 GCGTTCTACAGCGATGGCGA]

['TTTCAAGCCAACCCCATGGCCTCCAYGACTT

1939 NC_012920.1 :m.7505T>C 4574 MT-TS1 TTTCAAAAAGGTATTAGAAA']

NM_000084.4(CLCN5):c.674T> ['GTGGCTTGCTGCTGTGGGAACATCCYGTGCC

1940 C (p.Leu225Pro) 1184 CLCN5 ACTGCTTCAACAAATACAGG]

NM_000530.6(MPZ):c.89T>C ['GCAGTGCTGTCCCCGGCCCAGGCCAYCGTG

1941 (p.Ile30Thr) 4359 MPZ GTTTACACCGACAGGGAGGTC]

1942 NM_000530.6(MPZ):c.244T>C 4359 MPZ ['CCCTCATTCCTCATAGATCTTCCACYATGCC (p.Tyr82His) AAGGGACAACCCTACATTGA']

NM_000530.6(MPZ):c.266T>C ['CACTATGCCAAGGGACAACCCTACAHTGAC

1943 (p.Ile89Thr) 4359 MPZ GAGGTGGGGACCTTCAAAGAG]

NM_000748.2(CHRNB2):c.923T ['TACCTCATGTTCACCATGGTGCTTGYCACCT

1944 >C (p.Val308Ala) 1141 CHRNB2 TCTCCATCGTCACCAGCGTG]

NM_003611.2(OFDl):c. ll l+2T ['CGGGGTATACTGGATACACTCAAGGYATCG

1945 >C 8481 OFD1 GATTTAGGCGTATCTGTGTCA']

NM_003611.2(OFDl):c.274T>C ['AAGATGTGGCTATGAATATTCACTTYCTGTT

1946 (p.Ser92Pro) 8481 OFD1 TTCTTTCCAGAAAGTGGTTT']

NM_024408.3 (NOTCH2) : c.1117 ['GCCCCACCCTGTGACAGGTCTCCTGYGTCAT

1947 T>C (p.Cys373Arg) 4853 NOTCH2 CTGGATGATGCATGCATCAG]

NM_024408.3(NOTCH2):c. l438 [TCTGGATAAGATTGGAGGCTTCACAYGTCTG

1948 T>C (p.Cys480Arg) 4853 NOTCH2 TGCATGCCAGGTAAATGGGC]

NM_000540.2(RYRl):c.9242T> ['CCCCGCTGCCCTTCTAGGACAGTGAYGAAGT

1949 C (p.Met3081Thr) 6261 RYR1 CAGGCCCTGAGATCGTGAAG]

NM_000096.3(CP):c.650T>C ['AAAGAAAAACATATTGACCGAGAATYTGTG

1950 (p.Phe217Ser) 1356 CP GTGATGTTTTCTGTGGTGGAT']

NM_000096.3(CP):c.548T>C ['GTGACTAGGATTTACCATTCCCACABTGATG

1951 (p.Ilel83Thr) 1356 CP CTCCAAAAGATATTGCCTCA']

NM_000540.2(RYRl):c.1205T> ['CAGGAGGAGTCCCAGGCCGCCCGCAYGATC

1952 C (p.Met402Thr) 6261 RYR1 CACAGCACCAATGGCCTATAC]

NM_006517.4(SLC16A2):c. l253 ['TTCGGGGGCCTTATCGTCGTCTGTCYTTTCCT

1953 T>C (p.Leu418Pro) 6567 SLC16A2 GGGCCTTTGCGATGGCTTC]

NM_000096.3(CP):c. ll23T>C ['CCGTGGGAAGCATGTTAGACACTACYACAT

1954 (p.Tyr375His) 1356 CP TGCCGCTGAGGAAATCATCTG]

NM_002739.3(PRKCG):c.391T> ['CGGGCTTGTGCACCAGGGCATGAAAHGCTC

1955 C (p.Cysl31Arg) 5582 PRKCG CTGTGAGTGACCTGGGCCTTG]

NM_000116.4(TAZ):c.310T>C ['GACCCCTGCAGCTGCAGACATCTGCYTCACC

1956 (p.Phel04Leu) 6901 TAZ AAGGAGCTACACTCCCACTT']

NM_000138.4(FBNl):c.2341T> ['CAGTCTCCTTTGTGACAATGGACAAYGTAGA

1957 C (p.Cys781Arg) 2200 FBN1 AATACTCCTGGAAGTTTTGT']

NM_000138.4(FBNl):c.4222T> ['CTTTCTGGCTGTAGACCTTGATGAGYGCTCT

1958 C (p.Cysl408Arg) 2200 FBN1 GAGAACCTGAATCTCTGTGG]

NM_000256.3(MYBPC3):c.l351 ['GTAGCACGGAGCTCTTTGTGAAAGGYGGGC

1959 +2T>C 4607 MYBPC3 CTGGGACCTGAGGATGTGGGA']

NM_000256.3(MYBPC3):c3392 ['GACGCGGAAGTAGTAGCCATTGCCARTGAT

1960 T>C (p.Ilel l31Thr) 4607 MYBPC3 GAGCTCTGGCACCACGCAGTG]

NM_000256.3(MYBPC3):c.821+ ['CCTCCTATCAGCCTTCCGCCGCACGYGAGTG

1961 2T>C 4607 MYBPC3 GCCATCCTCAGGGCCTGGGG]

NM_000257.3(MYH7):c.l370T> ['ACCAAGCAGCCACGCCAGTACTTCAYAGGA

1962 C (p.Ile457Thr) 4625 MYH7 GTCCTGGACATCGCTGGCTTC]

NM_000257.3(MYH7):c.2093T> ['ATGCACCAGCTGCGCTGCAATGGTGYGCTG

1963 C (p.Val698Ala) 4625 MYH7 GAGGGCATCCGCATCTGCAGG]

1964 NM_000257.3(MYH7):c.2546T> 4625 MYH7 ['AAGAGTGCAGAAAGAGAGAAGGAGAYGGC C (p.Met849Thr) CTCCATGAAGGAGGAGTTCACA]

NM_000257.3(MYH7):c.2555T> ['GAAAGAGAGAAGGAGATGGCCTCCAHGAA

1965 C (p.Met852Thr) 4625 MYH7 GGAGGAGTTCACACGCCTCAAA']

NM_000257.3(MYH7):c.602T> ['CAGTACTTTGCTGTTATTGCAGCCAYTGGGG

1966 C (p.Ile201Thr) 4625 MYH7 ACCGCAGCAAGAAGGACCAG]

NM_000257.3(MYH7):c.788T> ['ACAGGAAAGTTGGCATCTGCAGACAYAGAG

1967 C (p.Ile263Thr) 4625 MYH7 ACCTGTGAGTGCCATGAATCT']

NM_000260.3 (MY07A) : c.5573 ['CTCCTGCCCCACGTGCAGCGCTTCCYGCAGT

1968 T>C (p.Leul858Pro) 4647 MY07A CCCGAAAGCACTGCCCACTC]

NM_000441. l(SLC26A4):c.164+ ['GGAGAGCCTGGCCAAGTGCTGCAGGYAGCG

1969 2T>C 5172 SLC26A4 GCCGCGCGGGCCTGCGTAGAG]

M_000441.1 (SLC26 A4) : c.2T> ['TCGCTGTCCTCTGGCTCGCAGGTCABGGCAG

1970 C (p.MetlThr) -1 - CGCCAGGCGGCAGGTCGGAG]

M_000441.1(SLC26A4):c.765+ ['AATGGAGTTCTCTCTATTATCTATGYAAGTG

1971 2T>C 5172 SLC26A4 TTGCTTCTTGCTCCAGGGAT']

NM_000551.3(VHL):c.497T>C ['CTGAAAGAGCGATGCCTCCAGGTTGYCCGG

1972 (p.Vall66Ala) 7428 VHL AGCCTAGTCAAGCCTGAGAAT']

NM_001399.4(EDA):c.2T>C ['AGAGAGTGGGTGTCTCCGGAGGCCAYGGGC

1973 (p.MetlThr) 1896 EDA TACCCGGAGGTGGAGCGCAGG]

NM_001943.3(DSG2):c.523+2T ['CTGTTGAAGAGTTGAGTGCAGCACGYAAGA

1974 >C 1829 DSG2 GTCTTTTTTTTTTTTTTTAAT']

NM_004572.3(PKP2):c.2062T> ['TTGCGGACACTTTTGGCGATCAAGGRCAGAT

1975 C (p.Ser688Pro) 5318 PKP2 ACATCCTTATAACAATGGAA']

NM_005633.3(SOSl):c.l310T> [' ATTGATGGTTGGGAGGGAAAAGAC AB TGGA

1976 C (p.Ile437Thr) 6654 SOS1 CAGTGTTGTAATGAATTTATA']

NM_170707.3(LMNA):c.799T> ['GTATAAGAAGGAGCTGGAGAAGACTYATTC

1977 C (p.Tyr267His) 4000 LMNA TGCCAAGGTGCTTGCTCTCGA']

NM_206933.2(USH2A):c.10561 ['TCTTGAAGATACAATTGTCTTAAACYGGAGA

1978 T>C (p.Trp3521Arg) 7399 USH2A AAACCTATACAATCAAATGG]

NM_206933.2(USH2A):c.l606T ['CGACACAACAAGCCAGCCATATAGAYGCCT

1979 >C (p.Cys536Arg) 7399 USH2A CTGCTCCCAGGAGAGCTTCAC]

NM_206933.2(USH2A):c.5857+ [' GTC G AGG AC GT AC A AC AGG AGC AGGY A A AT

1980 2T>C -1 - ACTTATCTTCAAATGCATATG]

NM_000492.3(CFTR):c.l090T> ['CTGGGCTGTACAAACATGGTATGACYCTCTT

1981 C (p.Ser364Pro) 1080 CFTR GGAGCAATAAACAAAATACA']

NM_000548.3(TSC2):c.5150T> ['CCCTTCGTGGCCCGCCAGATGGCCCYGCACG

1982 C (p.Leul717Pro) 7249 TSC2 CAAATGTGAGTGGGGGTGGG]

NM_000548.3(TSC2):c.2410T> ['CCTCATCCACCGCTGTGCCAGCCAGYGCGTC

1983 C (p.Cys804Arg) 7249 TSC2 GTGGCCTTGTCCATCTGCAG]

NM_000548.3(TSC2):c.3106T> ['GGACATGATGGCTCGATACGTCTTCYCCAAC

1984 C (p.Serl036Pro) 7249 TSC2 TTCACGGCTGTCCCGAAGAG]

NM_000212.2(ITGB3):c.2231T> ['GCCGCCCTGCTCATCTGGAAACTCCYCATCA

1985 C (p.Leu744Pro) -1 - CCATCCACGACCGAAAAGAA']

1986 NM_183415.2(UBE3B):c. l741+ 89910 UBE3B ['AGATGATCTGGGATGGAATTGTAGGYAAGA 2T>C GAAAAGGTGTCTGCTGTTGTT']

NM_005120.2(MED12):c.3493T ['CCTTTTAGCTTGTAGTGAACAGGACYCTGAG

1987 >C (p.Serll65Pro) 9968 MED12 CCAGGGGCCCGGCTTACCTG]

NM_001033053.2(NLRPl):c.230 ['CTAGCCCTCCATACCTGGGAGCAGAYGGGG

1988 T>C (p.Met77Thr) 22861 NLRP1 CTGAGGTCACTGTGCGCCCAA]

NM_025152.2(NUBPL):c.815- ['ATGCCTATATGAACTTTTCTGGTTCYAATGG

1989 27T>C 80224 NUBPL ATGTCTGCTGGGCTCTTTTA']

NM_001288953.1(TTC7A):c.236 ['GCGTGGCAGGGCCTGGGCGAGGTGCYGCAG

1990 6T>C (p.Leu789Pro) 57217 TTC7A GCCCAGGGCCAGAACGAGGCT']

NM_014845.5(FIG4):c.524T>C ['TACAGCTATGATTTGTCCCACTCACYTCAAT

1991 (p.Leul75Pro) 9896 FIG4 ATAATCTCACTGTCTTGCGA']

NM_000059.3(BRCA2):c.2T>C [' ATTGGAGGAATATCGTAGGTAAAAAB GCCT

1992 (p.MetlThr) 675 BRCA2 ATTGGATCCAAAGAGAGGCCA]

NM_000059.3(BRCA2):c.316+2 ['TAGATAAATTCAAATTAGACTTAGGYAAGT

1993 T>C 675 BRCA2 AATGCAATATGGTAGACTGGG]

NM_000059.3(BRCA2):c.67+2T ['TTAAGACACGCTGCAACAAAGCAGGHATTG

1994 >C 675 BRCA2 ACAAATTTTATATAACTTTAT']

NM_000059.3(BRCA2):c.7958T ['AGATGCCTAAGCCCAGAAAGGGTGCYTCTT

1995 >C (p.Leu2653Pro) 675 BRCA2 CAACTAAAATACAGGCAAGTT']

NM_000218.2(KCNQl):c. l016T ['TGCTTCTCTGTCTTTGCCATCTCCTHCTTTGC

1996 >C (p.Phe339Ser) 3784 KCNQ1 GCTCCCAGCGGTAGGTGCC]

NM_000218.2(KCNQl):c. l045T

>C (p.Ser349Pro) 3784 KCNQ1 []

NM_000218.2(KCNQl):c. l052T

>C (p.Phe351Ser) 3784 KCNQ1 []

NM_000218.2(KCNQl):c. l058T

>C (p.Leu353Pro) 3784 KCNQ1 []

NM_000218.2(KCNQl):c. l541T

>C (p.Ile514Thr) 3784 KCNQ1 []

NM_000218.2(KCNQl):c. l661T

>C (p.Val554Ala) 3784 KCNQ1 []

NM_000218.2(KCNQl):c. l700T ['CTTCTCTCCAGGCTGGACCAGTCCABTGGGA

1997 >C (p.Ile567Thr) 3784 KCNQ1 AGCCCTCACTGTTCATCTCC]

NM_000218.2(KCNQl):c.2T>C

(p.MetlThr) 3784 KCNQ1 []

NM_000218.2(KCNQl):c.341T>

C (p.Leul l4Pro) 3784 KCNQ1 []

NM_000218.2(KCNQl):c.560T> ['GGCTGCCGCAGCAAGTACGTGGGCCYCTGG

1998 C (p.Leul87Pro) 3784 KCNQ1 GGGCGGCTGCGCTTTGCCCGG]

NM_000218.2(KCNQl):c.572T>

C (p.Leul91Pro) 3784 KCNQ1 []

NM_000218.2(KCNQl):c.716T>

C (p.Leu239Pro) 3784 KCNQ1 []

NM_000218.2(KCNQl):c.752T> 3784 KCNQ1 [] C (p.Leu251Pro)

NM_000218.2(KCNQl):c.797T>

C (p.Leu266Pro) 3784 KCNQ1 []

NM_000218.2(KCNQ 1 ) : c.824T>

C (p.Phe275Ser) 3784 KCNQ1 []

NM_000218.2(KCNQl):c.910T>

C (p.Trp304Arg) 3784 KCNQ1 []

NM_000218.2(KCNQl):c.913T>

C (p.Trp305Arg) 3784 KCNQ1 []

NM_000492.3 (CFTR) :c .1021 T> ['CCTCCGGAAAATATTCACCACCATCYCATTC

1999 C (p.Ser341Pro) 1080 CFTR TGCATTGTTCTGCGCATGGC]

NM_000492.3(CFTR):c.l853T> ['TTAAAGAAAGCTGACAAAATATTAAYTTTG

2000 C (p.Ile618Thr) 1080 CFTR CATGAAGGTAGCAGCTATTTT']

NM_000492.3(CFTR):c.2780T> ['TACGTGGGAGTAGCCGACACTTTGCYTGCTA

2001 C (p.Leu927Pro) 1080 CFTR TGGGATTCTTCAGAGGTCTA']

NM_000492.3(CFTR):c.3230T> ['GGACGGCAGCCTTACTTTGAAACTCYGTTCC

2002 C (p.Leul077Pro) 1080 CFTR ACAAAGCTCTGAATTTACAT']

NM_007294.3(BRCAl):c. ll5T> ['GATCAAGGAACCTGTCTCCACAAAGNGTGA

2003 C (p.Cys39Arg) 672 BRCA1 CCACATATTTTGCAAGTAAGT']

NM_007294.3(BRCAl):c. l90T> ['GAAAGGGCCTTCACAGTGTCCTTTABGTAAG

2004 C (p.Cys64Arg) 672 BRCA1 AATGATATAACCAAAAGGTA']

NM_007294.3(BRCAl):c.212+2 ['ATGTAAGAATGATATAACCAAAAGGYATAT

2005 T>C 672 BRCA1 AATTTGGTAATGATGCTAGGT']

NM_007294.3(BRCAl):c.2T>C ['TAAAGTTC ATTGGAAC AGAAAGAAAB GGAT

2006 (p.MetlThr) 672 BRCA1 TTATCTGCTCTTCGCGTTGAA]

NM_007294.3(BRCAl):c.4357+ ['CAGAACAAAGCACATCAGAAAAAGGBGTGT

2007 2T>C 672 BRCA1 ATTGTTGGCCAAACACTGATA']

NM_007294.3(BRCAl):c.5291T ['CTCTTCTTCCAGATCTTCAGGGGGCYAGAAA

2008 >C (p.Leul764Pro) 672 BRCA1 TCTGTTGCTATGGGCCCTTC]

NM_007294.3(BRCAl):c.65T>C ['GTCATTAATGCTATGCAGAAAATCTYAGAGT

2009 (p.Leu22Ser) 672 BRCA1 GTCCCATCTGGTAAGTCAGC]

NM_005236.2(ERCC4):c.689T> ['ATGCTTGCTATACAGACTGCTATACYGGACA

2010 C (p.Leu230Pro) 2072 ERCC4 TTTTAAATGCATGTCTAAAG]

NM_005236.2(ERCC4):c.706T> ['TGCTATACTGGACATTTTAAATGCAYGTCTA

2011 C (p.Cys236Arg) 2072 ERCC4 AAGGAACTAAAATGCCATAA]

NM_000435.2(NOTCH3):c.4556 ['GGCGTGCTGGTGCTCACAGTGCTGCYGCCGC

2012 T>C (p.Leul519Pro) 4854 NOTCH3 CAGAGGAGCTACTGCGTTCC]

NM_153704.5(TMEM67):c. l046 ['GGAAATTTTCTCAAGTGGCAAACTTYAGAA

2013 T>C (p.Leu349Ser) 91147 TMEM67 GGAGGTGTTTTACAGGTAAGC]

NM_001142519.1(FAMl l lA):c. ['GTCTAAAAAAGCAGAAAGTCCAGAGYATGT

2014 1531T>C (p.Tyr511His) 63901 FAMl l lA CCATATGTATACTCAAAGAAG]

NM_014795.3(ZEB2):c.3211T> ['GCGCTTCTCACACTCGGGCTCGTACYCGCAG

2015 C (p.Serl071Pro) 9839 ZEB2 CACATGAATCACAGGTATTC]

2016 NM_001199107.1(TBClD24):c. 57465 TBC1D24 ['CCCCTCTGCTACTTCGCCCGGGTCTYTGACG 686T>C (p.Phe229Ser) TCTTCCTGGTGGAGGGCTAC]

NM_022114.3(PRDM16):c.2660 ['GTGGGAGCCCTGAAGGAGAAGTACCYGCGG

2017 T>C (p.Leu887Pro) 63976 PRDM16 CCGTCCCCGCTGCTCTTCCAC]

NM_001130089.1(KARS):c.517 ['AGCTTCTGGGGGAAAGCTCATCTTCYATGAT

2018 T>C (p.Tyrl73His) 3735 KARS CTTCGAGGAGAGGGGGTGAA']

NM_005689.2(ABCB6):c.1067T ['CTCATCTTCTCCCACCTGCACGAGCYCTCAC

2019 >C (p.Leu356Pro) 10058 ABCB6 TGCGCTGGCACCTGGGGCGC]

NM_001070.4(TUB Gl ) :c .1160T ['CCCCTGTTTTCTGCACACCCCAAGCYCTTCG

2020 >C (p.Leu387Pro) 7283 TUBG1 AGAGAACCTGTCGCCAGTAT']

NM_001283009.1(RTELl):c.373 ['CGGGCCCCTCTCAGCAGGCTGTGTGYGCCA

2021 0T>C (p.Cysl244Arg) -1 - GGGCTGTGGGGCAGAGGACGT']

NM_001135021.1(ELMOD3):c.7 ['ATCACCCACATTGCCATCCAGGCCTYGAGA

2022 94T>C (p.Leu265Ser) 84173 ELMOD3 GAGGAGTGTCTCTCCAGGTGA']

NM_001382.3(DPAGTl):c.503T ['CTACCATCTCTCCCCGCAGGAATCCYGTACT

2023 >C (p.Leul68Pro) 1798 DPAGT1 ATGTCTACATGGGGCTGCTG]

['CCATAAAATTCTTCTTAGTAGCTATYACCTT

2024 m.l0237T>C 4537 MT-ND3 CTTATTATTTGATCTAGAAA']

['TCCCTTCCCCTACTCATCGCACTAAYTTACA

2025 m.l l253T>C 4538 MT-ND4 CTCACAACACCCTAGGCTCA']

['ATCCTTCTTGCTCATCAGTTGATGAYACGCC

2026 m.l2811T>C 4540 MT-ND5 CGAGCAGATGCCAACACAGC]

['ATTCAGCTTCCTACACTATTAAAGTYTACCA

2027 m.l4325T>C 4541 MT-ND6 CAACCACCACCCCATCATAC]

NM_000142.4(FGFR3):c.2419T ['ACCCAGCAGTGGGGGCTCGCGGACGNGAAG

2028 >C (p.Ter807Arg) 2261 FGFR3 GGCCACTGGTCCCCAACAATG]

NM_000370.3(TTPA):c.548T>C ['GTAGCCAAGAAGATTGCTGCTGTACYTACG

2029 (p.Leul83Pro) 7274 TTPA GTAAATGTATATTTTAACTGT']

NM_000375.2(UROS):c.l39T>C ['TGAGTTTTTGTCTCTTCCCAGTTTCYCTGAGA

2030 (p.Ser47Pro) 7390 UROS AGGTAAGGCCTGTTGTGAC]

NM_001006657.1(WDR35):c.l5 ['TCTGGCACCATTCAGAGATACAGTCYACCTA

2031 92T>C (p.Leu531Pro) 57539 WDR35 ATGTTGGTTTGATTCAAAAA']

NM_001876.3(CPTlA):c.l451T ['GCAGATGCGCCGATCGTGGCCCACCYTTGG

2032 >C (p.Leu484Pro) 1374 CPT1A GAGGTGAGTTTTCACACTTTT']

NM_004595.4(SMS):c.449T>C ['GACGAAGATTCACCTTATCAAAATAYAAAA

2033 (p.Ilel50Thr) 6611 SMS ATTCTACACTCGAAGCAGTTT']

NM_005211.3(CSFlR):c.2483T> ['AAGTGGATGGCCCCAGAGAGCATCTYTGAC

2034 C (p.Phe828Ser) 1436 CSF1R TGTGTCTACACGGTTCAGAGC]

NM_170707.3(LMNA):c.644T> ['TCCTTCCTCCAACCCTTCCAGGAGCYGCGTG

2035 C (p.Leu215Pro) 4000 LMNA AGACCAAGCGCCGTCATGAG]

NM_194248.2(OTOF):c.3413T> ['CCACCCTCCAACCTCTCCCAGGTGCYGTTCT

2036 C (p.Leul l38Pro) 9381 OTOF GGGGCCTACGGGACCTAAAG]

NM_000540.2(RYRl):c.14762T ['TACAGGGTGGTCTTCGACATCACCTYCTTCT

2037 >C (p.Phe4921Ser) 6261 RYR1 TCTTCGTCATCGTCATCCTG]

2038 NM_000540.2(RYRl):c.7358T> 6261 RYR1 ['GCCGGCAAGGGTGAGGCCCTGCGGAYCCGC C (p.Ile2453Thr) GCCATCCTCCGCTCCCTTGTG]

NM_000540.2(RYRl):c. l0817T ['GAAGTGTCAGCCGTGCTCTACTACCYGGACC

2039 >C (p.Leu3606Pro) 6261 RYR1 AGGTGGGTGGGGCCGGAGGG]

NM_000540.2(RYRl):c.13703T ['TTTTACACCCTGCGGTTCCTTGCCCYCTTCTT

2040 >C (p.Leu4568Pro) 6261 RYR1 GGCATTTGCCATCAACTTC']

NM_000540.2(RYRl):c. l3949T ['CCCGCCCTGCGGTGTCTGAGCCTCCYGCATA

2041 >C (p.Leu4650Pro) 6261 RYR1 CACTGGTGGCCTTTCTCTGC]

NM_000540.2(RYRl):c.14378T ['GTGTGCCCACAGTCCTTCCTGTACCYGGGCT

2042 >C (p.Leu4793Pro) 6261 RYR1 GGTATATGGTGATGTCCCTC]

NM_015896.3(ZMYND10):c.79 ['CTCAGGGCTTAGCAGCAGGTTGTACRGGGC

2043 7T>C (p.Leu266Pro) 51364 ZMYND10 GATCCACACTTGCCCGTCCAA']

NM_018127.6(EL AC2) : c.460T> ['AAAATACCTCGAAGCAATCAAAATAYTTTCT

2044 C (p.Phel54Leu) 60528 ELAC2 GGTCCATTGAAAGGAATAGA']

NM_199355.2(ADAMTS18):c.6 17069 ADAMTSl ['CCTGCGGGTCACCATCCTCACGTACYGTACA

2045 05T>C (p.Leu202Pro) 2 8 AAAGGACAGCAGAGGAGAAG]

NM_023110.2(FGFRl):c.494T> [TCCCCAGAAAAGATGGAAAAGAAATYGCAT

2046 C (p.Leul65Ser) 2260 FGFR1 GCAGTGCCGGCTGCCAAGACA']

NM_001059.2(TACR3):c.766T> ['CCATATTATCGTCATTATACTGGTGYACTGT

2047 C (p.Tyr256His) 6870 TACR3 TTCCCATTGCTCATCATGGG]

NM_002055.4(GFAP):c. l070T> ['TACCAGGACCTGCTCAATGTCAAGCHGGCC

2048 C (p.Leu357Pro) 2670 GFAP CTGGACATCGAGATCGCCACC]

NM_002055.4(GFAP):c. l076T> ['GACCTGCTCAATGTCAAGCTGGCCCYGGAC

2049 C (p.Leu359Pro) 2670 GFAP ATCGAGATCGCCACCTACAGG]

NM_002055.4(GFAP):c. l096T> ['GGCCCTGGACATCGAGATCGCCACCYACAG

2050 C (p.Tyr366His) 2670 GFAP GAAGCTGCTAGAGGGCGAGGA]

NM_002055.4(GFAP):c.221T>C ['CGGGCCAGTGAGCGGGCAGAGATGAYGGAG

2051 (p.Met74Thr) 2670 GFAP CTCAATGACCGCTTTGCCAGC]

NM_002055.4(GFAP):c.247T>C ['GGAGCTCAATGACCGCTTTGCCAGCYACATC

2052 (p.Tyr83His) 2670 GFAP GAGAAGGTTCGCTTCCTGGA']

NM_002055.4(GFAP):c.269T>C ['AGCTACATCGAGAAGGTTCGCTTCCYGGAA

2053 (p.Leu90Pro) 2670 GFAP CAGCAAAACAAGGCGCTGGCT']

NM_002055.4(GFAP):c.290T>C ['TTCCTGGAACAGCAAAACAAGGCGCYGGCT

2054 (p.Leu97Pro) 2670 GFAP GCTGAGCTGAACCAGCTGCGG]

NM_002055.4(GFAP):c.302T>C ['CAAAACAAGGCGCTGGCTGCTGAGCYGAAC

2055 (p.LeulOlPro) 2670 GFAP CAGCTGCGGGCCAAGGAGCCC]

NM_002055.4(GFAP):c.704T>C ['GCCAAGCCAGACCTCACCGCAGCCCYGAAA

2056 (p.Leu235Pro) 2670 GFAP GAGATCCGCACGCAGTATGAG]

NM_002055.4(GFAP):c.739T>C ['CCGCACGCAGTATGAGGCAATGGCGYCCAG

2057 (p.Ser247Pro) 2670 GFAP CAACATGCATGAAGCCGAAGA']

NM_002055.4(GFAP):c.992T>C ['AGTTATCAGGAGGCGCTGGCGCGGCYGGAG

2058 (p.Leu331Pro) 2670 GFAP GAAGAGGGGCAGAGCCTCAAG]

NM_005554.3 (KRT6 A) :c .1406T ['GAGATCGCCACCTACCGCAAGCTGCBGGAG

2059 >C (p.Leu469Pro) 3853 KRT6A GGTGAGGAGTGCAGGTGGGTA']

2060 NM_005554.3(KRT6A):c.521T> 3853 KRT6A ['CAGATCAAGACCCTCAACAACAAGTBTGCC C (p.Phel74Ser) TCCTTCATCGACAAGGTGAGC]

NM_153490.2(KRT13):c.332T> ['AATGAGAAGATCACCATGCAGAACCYCAAC

2061 C fp.Leul llPro) 3860 KRT13 GACCGCCTGGCTTCCTACCTG]

NM_170707.3(LMNA):c. l619T> ['CCATGTCCCCACCAGGAAGTGGCCAYGCGC

2062 C (p.Met540Thr) 4000 LMNA AAGCTGGTGCGCTCAGTGACT']

NM_000218.2(KCNQl):c.1117T

>C (p.Ser373Pro) 3784 KCNQ1 []

NM_000218.2(KCNQl):c. l l35T ['TCCCCCTGCCCGACCTCAGACCGCABGGAG

2063 >C (p.Trp379Arg) 3784 KCNQ1 GTGCTATGCTGCCGAGAACCC]

NM_000218.2(KCNQl):c.1165T

>C (p.Ser389Pro) 3784 KCNQ1 []

NM_000218.2(KCNQl):c.1174T

>C (p.Trp392Arg) 3784 KCNQ1 []

NM_000218.2(KCNQl):c. l550T

>C (p.Ile517Thr) 3784 KCNQ1 []

NM_000218.2(KCNQl):c. l696T

>C (p.Ser566Pro) 3784 KCNQ1 []

NM_000218.2(KCNQl):c. l805T

>C (p.Leu602Pro) -1 - []

NM_000218.2(KCNQl):c.401T>

C (p.Leul34Pro) 3784 KCNQ1 []

NM_000218.2(KCNQl):c.550T> ['CTGGTCCGCCGGCTGCCGCAGCAAGBACGT

2064 C (p.Tyrl84His) 3784 KCNQ1 GGGCCTCTGGGGGCGGCTGCG]

NM_000218.2(KCNQ 1 ) : c.608T>

C (p.Leu203Pro) 3784 KCNQ1 []

NM_000218.2(KCNQl):c.625T>

C (p.Ser209Pro) 3784 KCNQ1 []

NM_000218.2(KCNQ 1 ) : c.742T>

C (p.Trp248Arg) 3784 KCNQ1 []

NM_000218.2(KCNQ 1 ) : c.749T> ['GACCGCCAGGGAGGCACCTGGAGGCHCCTG

2065 C (p.Leu250Pro) 3784 KCNQ1 GGCTCCGTGGTCTTCATCCAC]

NM_000218.2(KCNQ 1 ) : c.829T>

C (p.Ser277Pro) 3784 KCNQ1 []

NM_000218.2(KCNQl):c.832T>

C (p.Tyr278His) 3784 KCNQ1 []

NM_000218.2(KCNQl):c.845T>

C (p.Leu282Pro) 3784 KCNQ1 []

NM_000218.2(KCNQ 1 ) : c.908T>

C (p.Leu303Pro) 3784 KCNQ1 []

NM_000238.3 (KCNH2) : c.122T> ['AACGCTCGGGTGGAGAACTGCGCCGBCATC

2066 C (p.Val41Ala) 3757 KCNH2 TACTGCAACGACGGCTTCTGC]

NM_000238.3 (KCNH2) : c.1238T

>C (p.Leu413Pro) 3757 KCNH2 []

NM_000238.3(KCNH2):c. l279T 3757 KCNH2 [] >C (p.Tyr427His)

NM_000238.3 (KCNH2) : c.1387T

>C (p.Phe463Leu) 3757 KCNH2 []

NM_000238.3 (KCNH2) : c.160T>

C (p.Tyr54His) 3757 KCNH2 []

NM_000238.3(KCNH2):c. l655T ['GAGTACGGCGCGGCCGTGCTGTTCTYGCTCA

2067 >C (p.Leu552Ser) 3757 KCNH2 TGTGCACCTTTGCGCTCATC]

NM_000238.3(KCNH2):c. l691T

>C (p.Leu564Pro) 3757 KCNH2 []

NM_000238.3 (KCNH2) : c.1700T

>C (p.Ile567Thr) 3757 KCNH2 []

NM_000238.3 (KCNH2) : c.1702T

>C (p.Trp568Arg) 3757 KCNH2 []

NM_000238.3(KCNH2):c. l705T

>C (p.Tyr569His) 3757 KCNH2 []

NM_000238.3 (KCNH2) : c.1736T

>C (p.Met579Thr) 3757 KCNH2 []

NM_000238.3(KCNH2):c. l778T ['TGGCTGCACAACCTGGGCGACCAGANAGGC

2068 >C (p.Ile593Thr) 3757 KCNH2 AAACCCTACAACAGCAGCGGC]

NM_000238.3(KCNH2):c. l816T

>C (p.Ser606Pro) 3757 KCNH2 []

NM_000238.3(KCNH2):c. l879T ['CTTCAGCAGCCTCACCAGTGTGGGCHTCGGC

2069 >C (p.Phe627Leu) 3757 KCNH2 AACGTCTCTCCCAACACCAA']

NM_000238.3(KCNH2):c. l889T

>C (p.Val630Ala) 3757 KCNH2 []

NM_000238.3(KCNH2):c. l945T

>C (p.Ser649Pro) 3757 KCNH2 []

NM_000238.3(KCNH2):c. l985T

>C (p.Ile662Thr) 3757 KCNH2 []

NM_000238.3 (KCNH2) : c.202T>

C (p.Phe68Leu) 3757 KCNH2 []

NM_000238.3 (KCNH2) : c.2033 T

>C (p.Leu678Pro) 3757 KCNH2 []

NM_000238.3 (KCNH2) : c.206T>

C (p.Leu69Pro) 3757 KCNH2 []

NM_000238.3(KCNH2):c.2078T

>C (p.Leu693Pro) 3757 KCNH2 []

NM_000238.3(KCNH2):c.2309T

>C (p.Val770Ala) 3757 KCNH2 []

NM_000238.3 (KCNH2) : c.2414T ['TGGCCTCCAGGGAAGAATGACATCTBTGGG

2070 >C (p.Phe805Ser) 3757 KCNH2 GAGCCTCTGAACCTGTATGCA]

NM_000238.3(KCNH2):c.2452T

>C (p.Ser818Pro) 3757 KCNH2 []

NM_000238.3(KCNH2):c.2573T 3757 KCNH2 [] >C (p.Ile858Thr)

NM_000238.3(KCNH2):c.257T> ['GCTGCCGCGCAGATCGCGCAGGCACBGCTG

2071 C (p.Leu86Pro) 3757 KCNH2 GGCGCCGAGGAGCGCAAAGTG]

NM_000238.3 (KCNH2) : c.260T>

C (p.Leu87Pro) 3757 KCNH2 []

NM_000238.3(KCNH2):c.287T>

C (p.Ile96Thr) 3757 KCNH2 []

NM_000238.3(KCNH2):c.3146T

>C (p.Leul049Pro) 3757 KCNH2 []

NM_000238.3 (KCNH2) : c.322T>

C (p.Cysl08Arg) 3757 KCNH2 []

NM_000238.3(KCNH2):c.371T> ['AAGAACGAGGATGGGGCTGTC ATCAB GTTC

2072 C (p.Metl24Thr) 3757 KCNH2 ATCCTCAATTTCGAGGTGGTG]

NM_000238.3(KCNH2):c.65T>

C (p.Phe22Ser) 3757 KCNH2 []

NM_000238.3 (KCNH2) : c.86T>

C (p.Phe29Ser) 3757 KCNH2 []

NM_000238.3 (KCNH2) : c.872T>

C (p.Met291Thr) 3757 KCNH2 []

NM_000238.3(KCNH2):c.89T>

C (p.Ile30Thr) 3757 KCNH2 []

NM_000238.3 (KCNH2) : c.92T> ['GCCCCCCTAGGCCGTAAGTTCATCABCGCCA

2073 C (p.Ile31Thr) 3757 KCNH2 ACGCTCGGGTGGAGAACTGC]

NM_000891.2(KCN!2):c.301T>

C (p.CyslOlArg) 3759 KCNJ2 []

NM_000891.2(KCN12):c.650T>

C (p.Leu217Pro) 3759 KCNJ2 []

NM_000335.4(SCN5A):c.l l87T

>C (p.Val396Ala) 6331 SCN5A []

NM_000335.4(SCN5A):c.l l90T

>C (p.Ile397Thr) 6331 SCN5A []

NM_000335.4(SCN5A):c.2018T

>C (p.Leu673Pro) 6331 SCN5A []

NM_000335.4(SCN5A):c.2516T

>C (p.Leu839Pro) 6331 SCN5A []

NM_000335.4(SCN5A):c.2551T

>C (p.Phe851Leu) 6331 SCN5A []

NM_000335.4(SCN5A):c.2743T

>C (p.Cys915Arg) 6331 SCN5A []

NM_000335.4(SCN5A):c.2783T

>C (p.Leu928Pro) 6331 SCN5A []

NM_000335.4(SCN5A):c.278T>

C (p.Phe93Ser) 6331 SCN5A []

NM_000335.4(SCN5A):c.2804T 6331 SCN5A [] >C (p.Leu935Pro)

NM_000335.4(SCN5A):c.2944T ['CAAGCGGACCACCTGGGATTTCTGCYGTGGT

2074 >C (p.Cys982Arg) 6331 SCN5A CTCCTGCGGCAGCGGCCTCA]

NM_198056.2(SCN5A):c.3010T ['TGCCGCCCAGGGCCAGCTGCCCAGCYGCAT

2075 >C (p.Cysl004Arg) 6331 SCN5A TGCCACCCCCTACTCCCCGCC]

NM_000335.4(SCN5A):c.3679T ['TTGTCTGCAGGCCTTCGAGGACATCYACCTA

2076 >C (p.Tyrl227His) 6331 SCN5A GAGGAGCGGAAGACCATCAA]

NM_000335.4(SCN5A):c.3713T

>C (p.Leul238Pro) 6331 SCN5A []

NM_000335.4(SCN5A):c.3745T ['TGCCGACAAGATGTTCACATATGTCYTCGTG

2077 >C (p.Phel249Leu) 6331 SCN5A CTGGAGATGCTGCTCAAGTG]

NM_000335.4(SCN5A):c.3929T

>C (p.Leul310Pro) 6331 SCN5A []

NM_000335.4(SCN5A):c.4027T

>C (p.Phel343Leu) 6331 SCN5A []

NM_000335.4(SCN5A):c.4028T

>C (p.Phel343Ser) 6331 SCN5A []

NM_000335.4(SCN5A):c.4034T

>C (p.Leul345Pro) 6331 SCN5A []

NM_000335.4(SCN5A):c.4046T

>C (p.Ilel349Thr) 6331 SCN5A []

NM_000335.4(SCN5A):c.407T>

C (p.Leul36Pro) 6331 SCN5A []

NM_000335.4(SCN5A):c.4340T

>C (p.Ilel447Thr) 6331 SCN5A []

NM_000335.4(SCN5A):c.4415T [TTTATTGGTGTCATCATTGACAACTBCAACC

2078 >C (p.Phel472Ser) 6331 SCN5A AACAGAAGAAAAAGATACGT']

NM_000335.4(SCN5A):c.4453T

>C (p.Phel485Leu) 6331 SCN5A []

NM_198056.2(SCN5A):c.4493T

>C (p.Metl498Thr) 6331 SCN5A []

NM_000335.4(SCN5A):c.4742T

>C (p.Leul581Pro) 6331 SCN5A []

NM_000335.4(SCN5A):c.4778T

>C (p.Phel593Ser) 6331 SCN5A []

NM_000335.4(SCN5A):c.4952T ['CGCACGCTGCTCTTTGCCCTCATGABGTCCC

2079 >C (p.Metl651Thr) 6331 SCN5A TGCCTGCCCTCTTCAACATC]

NM_000335.4(SCN5A):c.5111T

>C (p.Phel704Ser) 6331 SCN5A []

NM_000335.4(SCN5A):c.5179T

>C (p.Cysl727Arg) 6331 SCN5A []

NM_000335.4(SCN5A):c.544T>

C (p.Cysl82Arg) 6331 SCN5A []

2080 NM_000335.4(SCN5A):c.5471T 6331 SCN5A ['TTTGCCGATGCCCTGTCTGAGCCACYCCGTA >C (p.Leul824Pro) TCGCCAAGCCCAACCAGATA]

NM_198056.2(SCN5A):c.5624T ['GAGATGGACGCCCTGAAGATCCAGAHGGAG

2081 >C (p.Metl875Thr) 6331 SCN5A GAGAAGTTCATGGCAGCCAAC]

NM_000335.4(SCN5A):c.635T> ['AGATACACAACTGAATTTGTGGACCHGGGC

2082 C (p.Leu212Pro) 6331 SCN5A AATGTCTCAGCCTTACGCACC]

NM_000335.4(SCN5A):c.689T>

C (p.Ile230Thr) 6331 SCN5A []

NM_198056.2(SCN5A):c.944T>

C (p.Leu315Pro) 6331 SCN5A []

NM_177976.2(ARL6):c.272T>C ['TTACACAGAGAAGGCCAAGCTATTAYTTTTG

2083 (p.Ile91Thr) 84100 ARL6 TCATTGATAGTAGTGATAGA']

NM_000487.5(ARSA):c.899T>C ['TCCCGAGGCGGCTGCTCCGGTCTCTYGCGGT

2084 (p.Leu300Ser) 410 ARSA GTGGAAAGGGAACGACCTAC]

NM_000267.3(NFl):c.l595T>C ['GAATTAATTACAGGGCTCGTCCAACYGGTCC

2085 (p.Leu532Pro) 4763 NF1 CTCAGTCACACATGCCAGAG]

NM_001042492.2(NFl):c.2288T ['CTTCAGAAAAGAGTGATGGCACTGCBGAGG

2086 >C (p.Leu763Pro) 4763 NF1 CGCATTGAGCATCCCACTGCA']

NM_004990.3(MARS):c. l l08T> ['CCTCACCAGAATCACCCAGGACATTYTCCAG

2087 C (p.Phe370Leu) 4141 MARS CAGTTGCTGAAACGAGGTTT']

NM_004990.3(MARS):c. l568T> ['TTCTATGTCTGGTTTGATGCCACTAYTGGCT

2088 C (p.Ile523Thr) 4141 MARS ATCTGTCCATCACAGCCAAC]

NM_006920.4(SCNlA):c.4729T ['GTTCATTGTGCTATTTACTGGAGAGYGTGTA

2089 >C (p.Cysl577Arg) -1 - CTGAAACTCATCTCTCTACG]

NM_006920.4(SCNlA):c.5113T ['TGAGACCTTTGGCAACAGCATGATCYGCCTA

2090 >C (p.Cysl705Arg) -1 - TTCCAAATTACAACCTCTGC]

NM_006920.4(SCNlA):c.838T> ['CAACCTGAGGAATAAATGTATACAAYGGCC

2091 C (p.Trp280Arg) 6323 SCN1A TCCCACCAATGCTTCCTTGGA']

NM_006920.4(SCNlA):c.269T> ['TGTTGTGTTCCTGTCTTACAGACTTYTATAGT

2092 C (p.Phe90Ser) 6323 SCN1A ATTGAATAAAGGGAAGGCC]

NM_006920.4(SCNlA):c.272T> ['TGTGTTCCTGTCTTACAGACTTTTAYAGTATT

2093 C (p.Ile91Thr) 6323 SCN1A GAATAAAGGGAAGGCCATC]

NM_006920.4(SCNlA):c.3827T ['TATTTCACCAATGCCTGGTGTTGGCYGGACT

2094 >C (p.Leul276Pro) -1 - TCTTAATTGTTGATGTAGGT']

NM_006920.4(SCNlA):c.5522T ['CCAAACAAACTCCAGCTCATTGCCAYGGATT

2095 >C (p.Metl841Thr) -1 - TGCCCATGGTGAGTGGTGAC]

NM_006920.4(SCNlA):c.568T> ['AGATTTTACTTTCCTTCGGGATCCAYGGAAC

2096 C (p.Trpl90Arg) 6323 SCN1A TGGCTCGATTTCACTGTCAT']

NM_002608.2(PDGFB):c.356T> ['ATAGACCGCACCAACGCCAACTTCCYGGTG

2097 C (p.Leul l9Pro) 5155 PDGFB TGGCCGCCCTGTGTGGAGGTG]

NM_000833.4(GRIN2A):c.2T>C ['TTGCAGGGACCGTCAGTGGCGACTAYGGGC

2098 (p.MetlThr) 2903 GRIN2A AGAGTGGGCTATTGGACCCTG]

NM_002474.2(MYHl l):c.3791T ['CTCCCCATCGCTGCACTTGGACTGCDGCTCC

2099 >C (p.Leul264Pro) 4629 MYH11 TGCACCTGCGCCTCCAGCTT']

2100 NM_014139.2(SCNl lA):c.2432 11280 SCN11A ['CTCAACCTCTTCATTGCCTTACTGCYCAATT T>C (p.Leu811Pro) CCTTTAGCAATGAGGAAAGA]

NM_006514.3(SCN10A):c.l661 ['GGAGTCAGGGTTGCTGGGTTGAGGARGAGG

2101 T>C (p.Leu554Pro) 6336 SCN10A GCTTCTAGGGAGGGGGCCTTG]

NM_000179.2(MSH6):c.l346T> ['CTTATTGGAGTCAGTGAACTGGGGCYGGTAT

2102 C (p.Leu449Pro) 2956 MSH6 TCATGAAAGGCAACTGGGCC]

NM_000179.2(MSH6):c.4001+2 ['GAATCAGTCACTACGATTATTTCGGYAACTA

2103 T>C 2956 MSH6 ACTAACTATAATGGAATTAT']

NM_000249.3(MLHl):c. l745T> ['GCTTCTTCCTAGGAGCCAGCACCGCYCTTTG

2104 C (p.Leu582Pro) 4292 MLH1 ACCTTGCCATGCTTGCCTTA']

NM_000249.3 (MLH 1 ) : c.2246T> ['CTGCAGCTTGCTAACCTGCCTGATCHATACA

2105 C (p.Leu749Pro) 4292 MLH1 AAGTCTTTGAGAGGTGTTAA']

NM_000249.3(MLHl):c.229T>C ['ACAGAAAGAAGATCTGGATATTGTAYGTGA

2106 (p.Cys77Arg) 4292 MLH1 AAGGTTCACTACTAGTAAACT']

NM_000249.3(MLHl):c.453+2T ['GGCAATCAAGGGACCCAGATCACGGYAAGA

2107 >C 4292 MLH1 ATGGTACATGGGAGAGTAAAT']

NM_000249.3(MLHl):c.739T>C ['AGCCTTCAAAATGAATGGTTACATABCCAAT

2108 (p.Ser247Pro) 4292 MLH1 GCAAACTACTCAGTGAAGAA']

NM_000249.3 (MLH 1 ) : c.790+2T ['GCATCTTCTTACTCTTCATCAACCGHAAGTT

2109 >C 4292 MLH1 AAAAAGAACCACATGGGAAA']

NM_000251.2(MSH2) :c.1319T> ['TTGTTGGCAGTTTTTGTGACTCCTCYTACTG

2110 C (p.Leu440Pro) 4436 MSH2 ATCTTCGTTCTGACTTCTCC]

NM_000251.2(MSH2):c.2005+2 ['AACAGATGTTCCACATCATTACTGGYAAAA

2111 T>C 4436 MSH2 AACCTGGTTTTTGGGCTTTGT']

NM_000251.2(MSH2):c.2089T> ['GGCCCAAATTGGGTGTTTTGTGCCAYGTGAG

2112 C (p.Cys697Arg) 4436 MSH2 TCAGCAGAAGTGTCCATTGT']

NM_000251.2(MSH2):c.560T>C ['CCTGATAATGATCAGTTCTCCAATCBTGAGG

2113 (p.Leul87Pro) 4436 MSH2 CTCTCCTCATCCAGATTGGA']

NM_000251.2(MSH2):c.595T>C ['CCTCATCCAGATTGGACCAAAGGAAYGTGT

2114 (p.Cysl99Arg) 4436 MSH2 TTTACCCGGAGGAGAGACTGC]

NM_000251.2(MSH2):c.929T>C ['TTGGATATTGCAGCAGTCAGAGCCCBTAACC

2115 (p.Leu310Pro) 4436 MSH2 TTTTTCAGGTAAAAAAAAAA']

NM_007294.3(BRCAl):c.134+2 ['AAAGTGTGACCACATATTTTGCAAGBAAGTT

2116 T>C 672 BRCA1 TGAATGTGTTATGTGGCTCC]

NM_001194998.1(CEP152):c.31 ['TATGAGGAAGACATCCTGACTGTACYTGGG

2117 49T>C (p.Leul050Pro) 22995 CEP 152 GTTCTTTTAAGTGATACCCAA']

NM_001271723.1 (FBX038) : c.6 ['AGGGGTGAATGTTCCTGAAATTCCTYGTATC

2118 16T>C (p.Cys206Arg) 81545 FBX038 CCAATGCTAAGGCACCTTTA']

M_014495.3(ANGPTL3):c.883 ['ACATCGAATAGATGGATCACAAAACYTCAA

2119 T>C (p.Phe295Leu) -1 - TGAAACGTGGGAGAACTACAA']

NM_003184.3(TAF2):c.l945T> ['CTCTCATAGCGGAGCTGATACTGCCRCATAA

2120 C (p.Trp649Arg) 6873 TAF2 AATCAGCTTGCTCAAATTCT']

NM_000016.5(ACADM):c.233T ['TTCTTCTAGTATCCAGTCCCCCTAAYTAGAA

2121 >C (p.Ile78Thr) 34 ACADM GAGCCTGGGAACTTGGTTTA']

2122 NM_000019.3(ACATl):c.730+2 38 ACAT1 ['TTCCTGTCACAGTTACAGTAAAAGGYAGAG T>C ATAATGTTCCAAAAAGGATGA]

NM_000143.3(FH):c. l255T>C ['GAAGCATCCCCCAGCAGCCTGGCTGRGTGT

2123 (p.Ser419Pro) 2271 FH AACACATTTTTAATCTTTGAG]

NM_000169.2(GLA):c.899T>C ['GCTCCTTTATTCATGTCTAATGACCYCCGAC

2124 (p.Leu300Pro) -1 - ACATCAGCCCTCAAGCCAAA]

NM_000202.6(IDS):c.587T>C ['GTGCTGGATGTTCCCGAGGGCACCTYGCCTG

2125 (p.Leul96Ser) 3423 IDS ACAAACAGAGCACTGAGCAA]

NM_000252.2(MTMl):c.688T> [TCTGACTTAACCATAGGTGCTGTCAYGGATT

2126 C (p.Trp230Arg) 4534 MTM1 CATCCAGAAAATAAGACGGT']

NM_000277.1 (P AH) : c.638T>C ['GAGTACAATCACATTTTTCCACTTCYTGAAA

2127 (p.Leu213Pro) 5053 PAH AGTACTGTGGCTTCCATGAA']

M_000404.2(GLBl):c.457+2T ['TTCTTCTCCGCTCCTCCGACCCAGGYAGGTT

2128 >C 2720 GLB1 GTTACAGATGTCTTGAGAAG]

NM_000528.3(MAN2Bl):c2436 ['AGAGATGGCTCGCTGGAGCTCATGGYGAGT

2129 +2T>C 4125 MAN2B1 GGGTCAGAGCCCCATCCGAGC]

NM_000531.5 (OTC) : c.540+2T> ['CTGGCTGATTACCTCACGCTCCAGGHTGGTT

2130 C 5009 OTC TATTTATTTGTCTTACAAAA']

NM_001005741.2(GBA):c.667T ['TTCACCGCTCCATTGGTCTTGAGCCRAGTGG

2131 >C (p.Trp223Arg) 2629 GBA GTGATGTCCAGGGGCTGGCA']

NM_000402.4(G6PD):c.473T>C ['CGCCTCAACAGCCACATGAATGCCCYCCAC

2132 (p.Leul58Pro) 2539 G6PD CTGGGGTCACAGGCCAACCGC]

NM_000402.4(G6PD):c.188T>C ['CACCGATGCACCCATGATGATGAATRTGTGT

2133 (p.Ile63Thr) -1 - GTATCCGACTGATGGAAGGC]

NM_006920.4(SCNlA):c.4251+ ['GGGTATCTCTCTTTGCTTCAAGTTGYAAGTG

2134 2T>C -1 - AACACTATTTTCTCTGAATA']

NM_002225.3(IVD):c.465+2T> ['CAGAAAGAGAAGTATCTCCCGAAGGYGAGG

2135 C 3712 IVD AAATGGAAATGTAATACACGC]

NM_003494.3(DYSF):c.1284+2 ['GAGGTCAGCTTTGCGGGGAAAATGGYAAGG

2136 T>C 8291 DYSF AGCAAGGGAGCAGGAGGGTTC]

NM_004006.2(DMD):c.2380+2T ['CCCTGGTGGAACAGATGGTGAATGGYAATT

2137 >C 1756 DMD ACACGAGTTGATTTAGATAAT']

NM_012463.3 (ATP6V0A2) : c.82 ['ACCCGCATCCAGGATCTCTACACTGYGAGTA

2138 5+2T>C 23545 ATP6V0A2 AGCTGGAAGTGGATTGCCTC]

NM_014795.3(ZEB2):c.73+2T> ['AAGCCAATCCCAGGAGGAAAAACGGYAAG

2139 C 9839 ZEB2 AAGCAGCCCGAACCAAACTTTT']

NM_016725.2(FOLRl):c.493+2 ['ACAAGGGCTGGAACTGGACTTCAGGYGAGG

2140 T>C 2348 FOLRl GCTGGGGTGGGCAGGAATGGA']

NM_000056.3(BCKDHB):c.752 ['CCTGTTCTGTATTTAGCGGAAGAAGYCCCTA

2141 T>C (p.Val251Ala) 594 BCKDHB TAGAACCATACAACATCCCA']

NM_175053.3(KRT74):c.821T> 12139 ['TACTGCATCATACAGACACTTGAGGRACTTG

2142 C (p.Phe274Ser) 1 KRT74 ATTTCTTTGTCCAGTGAGTC]

NM_003764.3(STXll):c.l73T> ['GACATTCAGGATGAAAACCAGCTGCYGGTG

2143 C (p.Leu58Pro) 8676 STX11 GCCGACGTGAAGCGGCTGGGA']

2144 M_001044.4(SLC6 A3 ) : c.671 T 6531 SLC6A3 ['CTCTGCAGACGTGGCGTGCTGCACCYCCACC >C (p.Leu224Pro) AGAGCCATGGCATCGACGAC]

NM_015662.2(IFT172):c.5179T ['CTGATGAATTTCAGCACGTCCTGGCRCACTG

2145 >C (p.Cysl727Arg) -1 - GGCTGTGGGAGGTCTGTGAG]

NM_015662.2(IFT172):c.4607T ['GCGCGTGGCATAGTAATGAGCGATCRGCAG

2146 >C (p.Leul536Pro) 26160 IFT172 CATCGTCTTGAACTCCTCATG]

M_014754.2(PTDSSl):c.794T ['ACCGGGAAGATCAAGAGAGCTGTTCYGCAG

2147 >C (p.Leu265Pro) 9791 PTDSS1 TTCACTCCTGCTAGCTGGACC]

M_014714.3(IFT140):c.4078T ['GGACCCCAAGGAGTCCATCAAGCAGYGTGA

2148 >C (p.Cysl360Arg) 9742 IFT140 GCTGCTCCTGGAGGAACCAGA']

NM_000531.5(OTC):c. l005+2T ['GAAAACAGAAAGTGGACAATCATGGYAAGC

2149 >C 5009 OTC AAGAAACAAGGAATGGAGGAT']

NM_000531.5(OTC):c. l018T>C ['GTTGTGTCATCAGGCTGTCATGGTGYCCCTG

2150 (p.Ser340Pro) 5009 OTC CTGACAGATTACTCACCTCA']

NM_000531.5(OTC):c. l022T>C ['TGTCATCAGGCTGTCATGGTGTCCCYGCTGA

2151 (p.Leu341Pro) 5009 OTC CAGATTACTCACCTCAGCTC]

NM_000531.5(OTC):c. l033T>C ['TGTCATGGTGTCCCTGCTGACAGATBACTCA

2152 (p.Tyr345His) 5009 OTC CCTCAGCTCCAGAAGCCTAA']

NM_000531.5(OTC):c. l43T>C ['CGTGACCTTCTCACTCTAAAAAACTYTACCG

2153 (p.Phe48Ser) 5009 OTC GAGAAGAAATTAAATATATG]

NM 000531.5 (OTC) : c.158T>C ['CTAAAAAACTTTACCGGAGAAGAAABTAAA

2154 (p.Ile53Thr) 5009 OTC TATATGCTATGGCTATCAGCA']

NM_000531.5(OTC):c. l67T>C ['TTTACCGGAGAAGAAATTAAATATAYGCTA

2155 (p.Met56Thr) 5009 OTC TGGCTATCAGCAGATCTGAAA']

NM_000531.5(OTC):c. l88T>C ['TATATGCTATGGCTATCAGCAGATCYGAAAT

2156 (p.Leu63Pro) 5009 OTC TTAGGATAAAACAGAAAGGA']

NM_000531.5 (OTC) : c.227T>C ['GTCCTTGATTTATAGTATTTGCCTTYATTGCA

2157 (p.Leu76Ser) 5009 OTC AGGGAAGTCCTTAGGCATG]

NM_000531.5 (OTC) : c.284T>C ['GAGAAAAGAAGTACTCGAACAAGATYGTCT

2158 (p.Leu95Ser) 5009 OTC ACAGAAACAGGTAAGTCCACT']

NM_000531.5(OTC):c.2T>C ['CGTCCTTTACACAATTAAAAGAAGAYGCTGT

2159 (p.MetlThr) 5009 OTC TTAATCTGAGGATCCTGTTA']

NM_000531.5 (OTC) : c.386+2T> ['TGAAAGTCTCACGGACACGGCCCGGYTTGT

2160 C 5009 OTC AAATATTTTCTTCTCTCCAAA']

NM_000531.5 (OTC) : c.392T>C ['TTTTTCTTGGTTTGCCACAGTGTATYGTCTAG

2161 (p.Leul31Ser) 5009 OTC CATGGCAGATGCAGTATTG]

NM_000531.5 (OTC) : c.394T>C ['TTTCTTGGTTTGCCACAGTGTATTGYCTAGC

2162 (p.Serl32Pro) 5009 OTC ATGGCAGATGCAGTATTGGC]

NM_000531.5 (OTC) : c.416T>C ['TTGTCTAGCATGGCAGATGCAGTATYGGCTC

2163 (p.Leul39Ser) 5009 OTC GAGTGTATAAACAATCAGAT']

NM_000531.5(OTC):c.443T>C ['GCTCGAGTGTATAAAC AATCAGATTB GGAC

2164 (p.Leul48Ser) 5009 OTC ACCCTGGCTAAAGAAGCATCC]

NM_000531.5 (OTC) : c.476T>C ['CTGGCTAAAGAAGCATCCATCCCAAYTATC

2165 (p.Ilel59Thr) 5009 OTC AATGGGCTGTCAGATTTGTAC]

2166 NM_000531.5(OTC):c.479T>C 5009 OTC ['GCTAAAGAAGCATCCATCCCAATTANCAAT (p.Ilel60Thr) GGGCTGTCAGATTTGTACCAT']

NM_000531.5 (OTC) : c.490T>C ['ATCCATCCCAATTATCAATGGGCTGYCAGAT

2167 (p.Serl64Pro) 5009 OTC TTGTACCATCCTATCCAGAT']

NM_000531.5 (OTC) : c.526T>C ['CCATCCTATCCAGATCCTGGCTGATYACCTC

2168 (p.Tyrl76His) 5009 OTC ACGCTCCAGGTTGGTTTATT']

NM_000531.5(OTC):c.536T>C ['CAGATCCTGGCTGATTACCTCACGCYCCAGG

2169 (p.Leul79Pro) 5009 OTC TTGGTTTATTTATTTGTCTT']

NM_000531.5 (OTC) : c.577T>C ['CTCTCTGAAAGGTCTTACCCTCAGCBGGATC

2170 (p.Tipl93Arg) 5009 OTC GGGGATGGGAACAATATCCT']

NM_000531.5 (OTC) : c.602T>C ['TGGATCGGGGATGGGAACAATATCCYGCAC

2171 (p.Leu201Pro) 5009 OTC TCCATCATGATGAGCGCAGCG]

NM_000531.5(OTC):c.663+2T> ['CACCTTCAGGCAGCTACTCCAAAGGYAGGG

2172 C 5009 OTC AAACTTTTTGCCTTGAAACTA']

NM_000531.5(OTC):c.779T>C ['GAAGCAGCGCATGGAGGCAATGTATYAATT

2173 (p.Leu260Ser) 5009 OTC ACAGACACTTGGATAAGCATG]

NM_000531.5(OTC):c.793T>C ['AGGCAATGTATTAATTACAGACACTYGGAT

2174 (p.Trp265Arg) 5009 OTC AAGCATGGGACAAGAAGAGGA']

NM_000531.5(OTC):c.803T>C ['TTAATTACAGACACTTGGATAAGCAYGGGA

2175 (p.Met268Thr) 5009 OTC CAAGAAGAGGAGAAGAAAAAG]

NM_000531.5 (OTC) : c.907T>C ['TGCCTCTGACTGGACATTTTTACACBGCTTG

2176 (p.Cys303Arg) 5009 OTC CCCAGAAAGCCAGAAGAAGT']

NM_000531.5 (OTC) : c.947T>C ['CCAGAAGAAGTGGATGATGAAGTCTYTTAT

2177 (p.Phe316Ser) 5009 OTC TCTCCTCGATCACTAGTGTTC]

NM_000322.4(PRPH2):c.637T> ['CCTGGTGGACGGCGTCCCTTTCAGCYGCTGC

2178 C (p.Cys213Arg) 5961 PRPH2 AATCCTAGCTCGCCACGGCC]

NM_000322.4(PRPH2):c.736T> ['CCACCAGACGGAGGAGCTCAACCTGYGGGT

2179 C (p.Trp246Arg) 5961 PRPH2 GCGTGGCTGCAGGGCTGCCCT']

NM_017415.2(KLHL3):c.l l60T

>C (p.Leu387Pro) 26249 KLHL3 []

NM_017415.2(KLHL3):c.l280T

>C (p.Met427Thr) 26249 KLHL3 []

NM_003859.1(DPMl):c.742T>C ['AGAGTCAATAATCCTTTCAAGAAAGRTACTA

2180 (p.Ser248Pro) -1 - TTTCATTTCCTCCCAACTTG]

NM_004826.3(ECELl):c.2278T ['GGGTTCATGGGTGAGTCCTTGGGACRGTGG

2181 >C (p.Cys760Arg) 9427 ECEL1 AAAGCCCGGCCAAACTCCTCA']

NM_014908.3(DOLK):c.2T>C ['GGCCGGAGATGGGCACTCTCGGGTCRTATCT

2182 (p.MetlThr) 22845 DOLK CTAGACCTGGGGCTTCACGG]

M_000404.2(GLB 1 ) :c .922T>C ['TCTTTTGTTTCCTTGTAGGTACATGYTTATAG

2183 (p.Phe308Leu) 2720 GLB1 GTGGGACCAATTTTGCCTA']

NM_012434.4(SLC17A5):c.500 ['TTAGGAGTTGGACCACTCATTGTACYCAGAG

2184 T>C (p.Leul67Pro) 26503 SLC17A5 CACTAGAAGGACTAGGAGAG]

NM_000211.4(ITGB2):c. l877+2 ['CCCCTCACCCTGTGGCAAGTACATGYGAGTG

2185 T>C 3689 ITGB2 CAGGCGGAGCAGGCAGGGCG]

2186 NM_006702.4(PNPLA6):c.3053 10908 PNPLA6 ['ACCTCCATGTTCACTGGGTCTGCCTYTAACC T>C (p.Phel018Ser) GCAGCATCCATCGGGTCTTC']

NM_176787.4(PIGN):c.808T>C [TCTGAAGGATGACCAGCCCCATGGGRACCT

2187 (p.Ser270Pro) 23556 PIGN ACAAATAAGATATAAAGAATA]

NM_001165899.1(PDE4D):c. l85 ['CCATGTCTCCCAGAGGGGATGAACARTATA

2188 0T>C (p.Ile617Thr) 5144 PDE4D GTCTATGAAGCCCACCTAGTT']

NM_005017.3(PCYTlA):c.571T ['CCTTCTGTCCTCTGTGTTGGAGCAARCATGC

2189 >C (p.Phel91Leu) 5130 PCYT1A CTAACTCAGAAACACATACA']

NM_000090.3(COL3Al):c.951+ ['CAGGACTTCCTGGGGCTGCAGTGAGHATAG

2190 6T>C (p.Gly300_Ala317del) 1281 COL3A1 CTGCTAACATCACACAATTAC]

NM_000090.3(COL3Al):c.2022 ['GCACCTGGAGCTCCAGGAGGCAAGGYAGTA

2191 +2T>C (p.Gly660_Lys674del) 1281 COL3A1 TTTCAATTTATTCTCTACCTT']

NM_000090.3(COL3Al):c.951+ ['CGGCCAGGACTTCCTGGGGCTGCAGHGAGT

2192 2T>C (p.Gly300_Ala317del) 1281 COL3A1 ATAGCTGCTAACATCACACAA']

NM_000090.3(COL3Al):c.3093 ['CGAGATGGATCTCCTGGTGGCAAGGBATAA

2193 +2T>C (p.Glyl014_Lysl031del) 1281 COL3A1 TAAACACATGTGCAATTGATT']

NM_000090.3(COL3Al):c.2337 ['CCAGCTGGCCAGCCTGGAGATAAGGYAACC

2194 +2T>C (p.Gly762_Lys779del) 1281 COL3A1 CTTAATACTACCTGGATATAA']

NM_000090.3(COL3Al):c.l761 ['TTCCCCGGTCCTAAAGGAAATGATGBGAGTT

2195 +2T>C (p.Gly555_Asp587del) 1281 COL3A1 CCTTCATTAATTTCTTCAAT']

NM_000090.3(COL3Al):c.3039

+6T>C

(p.Aspl013_Glyl014insVSSSFY ['CTGGTGAACCTGGAAGAGATGTGAGYAGCA

2196 STSQ) 1281 COL3A1 GTTTTTATTCAACCAGCCAGG]

NM_000090.3(COL3Al):c.4399 ['GGACGTTGGCCCTGTTTGCTTTTTAYAAACC

2197 T>C (p.Terl467Gln) 1281 COL3A1 AAACTCTATCTGAAATCCCA']

NM_000090.3(COL3Al):c.2553 ['CCCCCTGGAGGTTCTGGACCTGCTGYAAGTT

2198 +2T>C (p.Gly816_Ala851del) 1281 COL3A1 CCTTCCTCTTTCTCTGTCTA']

NM_001278503.1(STT3A):c. l87 ['TATACTCCAACTGGGGAGTTCCGTGYGGACC

2199 7T>C (p.Val626Ala) 3703 STT3A GTGAAGGTTCTCCAGTGCTG]

NM_000277.1(PAH):c.691T>C ['TAACATTCCCCAGCTGGAAGACGTTYCTCAG

2200 (p.Ser231Pro) 5053 PAH TTCCTGCAGAGTAAGTCCAC]

NM_007294.3(BRCAl):c.5467+ ['GGACAGAGGACAATGGCTTCCATGGBAAGG

2201 2T>C 672 BRCA1 TGCCTGCATGTACCTGTGCTA']

NM_020347.3 (LZTFL 1 ) : c.260T ['ATACCACTTCTCAGCTTGTGCAAACRGCTGT

2202 >C (p.Leu87Pro) 54585 LZTFL 1 CGCAGAAGTAACACATTGGT']

NM_016381.5(TREXl):c.530T> ['CGCCAGCCACAGCCCTGGTGCCTGGYGGCA

2203 C (p.Vall77Ala) 11277 TREXl CACAATGGTGACCGCTACGAC]

M_015474.3(SAMHDl):c. l l06 ['TTTGTGTTGATAAGCTCTACGGTGTRAAGAG

2204 T>C (p.Leu369Ser) 25939 SAMHDl TTGCGAGTGTGGAACATGTC]

NM_005654.5(NR2Fl):c.755T> ['CAGATCACCGACCAGGTGTCCCTGCYACGC

2205 C (p.Leu252Pro) 7025 NR2F1 CTCACCTGGAGCGAGCTGTTC]

NM_003638.2(ITGA8):c.2982+2 ['TGCCTATATATATTTAAAGATACTCRCTACT

2206 T>C 8516 ITGA8 ATGCTTCCTTCTGGGAGTTT']

2207 NM_000321.2(RBl):c.2663+2T> 5925 RBI ['AGGATCAGATGAAGCAGATGGAAGGYAGG C AACCAGTTTTGAATGTTTTCCA']

NM_000321.2(RBl):c. l472T>C ['CATATGTCTTTATTGGCGTGCGCTCYTGAGG

2208 (p.Leu491Pro) 5925 RBI TTGTAATGGCCACATATAGC]

NM_015884.3(MBTPS2):c.l391 ['GCTATTGTTAATGCAGTACCCTGCTYTGCTT

2209 T>C (p.Phe464Ser) 51360 MBTPS2 TGGATGGACAATGGATTCTA']

NM_001739.1(CA5A):c.697T>C ['TCGGTCAGCGGCGGGGTGGTGAGCGRGCCC

2210 (p.Ser233Pro) 763 CA5A GCGTAGGTCCAGTAATCCCAG]

NM_005051.2(QARS):c. l69T>C ['TCCCTGAGTCGGGAGGCCAAGCCATRTAAC

2211 (p.Tyr57His) 5859 QARS AGGATCCCGGTAGCTTTGTCA']

NM_005356.4(LCK):c. l022T>C ['GGCATCAAGTTGACCATCAACAAACYCCTG

2212 (p.Leu341Pro) 3932 LCK GACATGGCAGCCCAAGTAAGG]

NM_021803.3 (IL21 ) : c.146T>C ['TACCAAGTCATTCACATAATTTTTCRGCTGA

2213 (p.Leu49Pro) 59067 IL21 TCAACAATATCTATAAGTTG]

NM_005861.3(STUBl):c.719T> ['TGTGGCAAGATCAGCTTTGAGCTGAYGCGG

2214 C (p.Met240Thr) -1 - GAGCCGTGCATCACGCCCAGT']

NM_032575.2(GLIS2):c.523T>C ['TCAGAACACTTCCCATCCTCCGCAGYGTAAC

2215 (p.Cysl75Arg) 84662 GLIS2 CAGCTCTTTGAGCTCCTGCA']

NM_001101.3(ACTB):c.224T>C ['CTGAAGTACCCCATCGAGCACGGCAYCGTC

2216 (p.Ile75Thr) 60 ACTB ACCAACTGGGACGACATGGAG]

NM_001101.3(ACTB):c.356T>C ['AACCCCAAGGCCAACCGCGAGAAGAYGACC

2217 (p.Metll9Thr) 60 ACTB CAGGTGAGTGGCCCGCTACCT']

NM_003401.3(XRCC4):c. l27T> ['TACACTTACTGATGGTCATTCAGCAYGGACT

2218 C (p.Trp43Arg) 7518 XRCC4 GGGACAGGTAATACTAAAAA]

NM_000051.3(ATM):c.2638+2T ['CTGGAGAGAGCCAAAGTACCATAGGYAAAT

2219 >C 472 ATM ACATATTTACTACTTGGGATT']

NM_000535.5 (PMS2) : c.2T>C ['CGAGGCGGATCGGGTGTTGCATCCAHGGAG

2220 (p.MetlThr) 5395 PMS2 CGAGCTGAGAGCTCGAGGTGA']

NM_015713.4(RRM2B):c.l90T> ['ATGCCACGTACCTCTTCTGCTGTCCRGAAGG

2221 C (p.Trp64Arg) 50484 RRM2B AAGCCTGTGCCTGTTTATAC]

NM_015713.4(RRM2B):c.368T> ['CTCGATGAGAATTTGAAAGCCATAGRAACA

2222 C (p.Phel23Ser) 50484 RRM2B GCGAGCCTCTGGAACCTGCAC]

NM_003122.4(SPINKl):c.194+2 ['TTAAAAGAAACTCAAGTTTGTACTCRCCGAT

2223 T>C 6690 SPINK1 TTTCAAAACATAACACGCAT']

NM_003122.4(SPINKl):c.l60T> ['AAACATAACACGCATTCATTGGGATRAGTAT

2224 C (p.Tyr54His) 6690 SPINK1 TTCCATCAGTCCCACAGACA']

NM_000219.5(KCNEl):c. l58T>

C (p.Phe53Ser) 3753 KCNE1 []

NM_000219.5(KCNEl):c. l76T> ['GCGGATGTAGCTCAGCATGATGCCCRGGGT

2225 C (p.Leu59Pro) 3753 KCNE1 GAAGAAGCCGAAGAATCCCAG]

NM_000219.5 (KCNE 1 ) : c.259T>

C (p.Trp87Arg) 3753 KCNE1 []

NM_017890.4(VPS13B):c.11119 15768 ['CGTTTGTAAAGCACATCTCCAAAGGYAGCG

2226 +2T>C 0 VPS13B GGTTCCGTTCCTTGTAATAAT']

2227 NM_005026.3(PIK3CD):c.l246T 5293 PIK3CD ['CACCTGCCCTGTCCTTCTGCAGGACYGCCCC >C (p.Cys416Arg) ATTGCCTGGGCCAACCTCAT']

NM_000271.4(NPCl):c.2054T> ['TACATTGGGTTGCCCTTGACCCTCAYTGTGA

2228 C (p.Ile685Thr) 4864 NPC1 TTGAAGTCATCCCGTTCCTG]

NM_002633.2(PGMl):c.l547T> ['GGGAGTGCCGGGGCCACCATTCGGCYGTAC

2229 C (p.Leu516Pro) 5236 PGM1 ATCGATAGCTATGAGAAGGAC]

NM_015599.2(PGM3):c.248T>C ['TTGGTTGATCCTTTGGGTGAAATGTYGGCAC

2230 (p.Leu83Ser) 5238 PGM3 CATCCTGGGAGGAACATGCC]

NM_002136.2(HNRNPAl):c.817 ['GAATTACAACAATCAGTCTTCAAATBTTGGA

2231 T>C (p.Phe273Leu) 3178 HNRNPA1 CCCATGAAGGGAGGAAATTT']

NM_002136.2(HNRNPAl):c.841 ['TTTTGGACCCATGAAGGGAGGAAATYTTGG

2232 T>C (p.Phe281Leu) 3178 HNRNPA1 AGGCAGAAGCTCTGGCCCCTA]

NM_001159287.1(TPIl):c.833T ['GGTGGTGCTTCCCTCAAGCCCGAATYCGTGG

2233 >C (p.Phe278Ser) 7167 TPIl ACATCATCAATGCCAAACAA']

NM_130838.1(UBE3A):c.2T>C ['TCTGACGACATTGAAGCTAGCCGAAYGTAA

2234 (p.MetlThr) 7337 UBE3A GTGTAACTTGGTTGAGACTGT']

NM_130838.1(UBE3A):c.710T> ['ATTGAAACTGCCTTTCTCAATGCACHTGTAT

2235 C (p.Leu237Pro) 7337 UBE3A ATTTGTCACCTAACGTGGAA']

M_000414.3(HSD17B4):c.l54 ['AGTGGAGACTGGAATCCCTTACACAYTGAT

2236 7T>C (p.Ile516Thr) 3295 HSD17B4 CCTAACTTTGCTAGTCTAGCA']

NM_022068.3 (PIEZ02) : c.8215T ['GTCCATTTGATCATTGTCTCTGGTGRGCGAT

2237 >C (p.Ser2739Pro) 63895 PIEZ02 ATAGGAATATTAATTTGGCA']

NM_012079.5(DGATl):c.751+2 ['GCACCTCAGGCCCACAGAGGTCCTCRCCGC

2238 T>C 8694 DGAT1 GGTAGGTCAGATTGTCCGGGT']

NM_003108.3(SOXl l):c.l78T> ['GCCGATGAACGCGTTCATGGTATGGYCCAA

2239 C (p.Ser60Pro) 6664 SOX11 GATCGAACGCAGGAAGATCAT']

NM_021072.3(HCNl):c.814T>C 34898 ['TGATGTATGTATCTAATTAACCTTGRAAGTC

2240 (p.Ser272Pro) 0 HCN1 GTAATAAACGCAAGAGACTG]

NM_001079867.1 (PEX2) : c.739T ['CACCAGTGGCAAAGAATGCGCTCTAYGTGG

2241 >C (p.Cys247Arg) 5828 PEX2 AGAGTGGCCCACCATGCCTCA']

NM_022552.4(DNMT3A):c. l94 ['CTGAATGCCCAAGTCCTTCAGCACCRGGAGC

2242 3T>C (p.Leu648Pro) 1788 DNMT3A CCTGCACCAGCCAGCAGACA']

NM_022552.4(DNMT3A):c.270 ['CGCAAAATACTCCTTCAGCGGAGCGRAGAG

2243 5T>C (p.Phe902Ser) 1788 DNMT3A GTGGCGGATGACTGGCACGCT']

NM_018400.3(SCN3B):c.482T> ['GAGGAAGACCAGAAGGATGTACATCRTGAT

2244 C (p.Metl61Thr) 55800 SCN3B TTCTGAGACCACAGAGGTGAA]

NM_000406.2(GNRHR) : c.392T ['TTCTCCATGTATGCCCCAGCCTTCAYGATGG

2245 >C (p.Metl31Thr) 2798 GNRHR TGGTGATCAGCCTGGACCGC]

NM_001030001.2(RPS29):c.l49 ['GCAGACGCCTACCTTAATGAAACCGRTATCC

2246 T>C (p.Ile50Thr) 6235 RPS29 TTCGCGTACTGACGGAAACA']

NM_177550.4(SLC13A5):c. l463 28411 ['CAGGGTACAGGGCAGCATGATGTACRGCGG

2247 T>C (p.Leu488Pro) 1 SLC13A5 ATTGAGGCCGATGGAGCGAGA']

M_004464.3(FGF5):c.520T>C ['TTTTCAAGAAAATAGCTATAATACCBATGCC

2248 (p.Tyrl74His) 2250 FGF5 TCAGCAATACATAGAACTGA']

2249 NM_000051.3 (ATM) : c.4776+2T 472 ATM ['AGAGGACCCTTTTCACTCTTGGAGGYAATAA >C AAATTTCATCATCTACTATT']

NM_002880.3(RAFl):c.l808T> ['GTGTTGGAGCAGCTCAATGGAAGACRGGAT

2250 C (p.Leu603Pro) 5894 RAF1 CTGAAACAAAGCCCAAGAATG]

NM_000251.2(MSH2):c.942+2T ['GTCAGAGCCCTTAACCTTTTTCAGGBAAAAA

2251 >C 4436 MSH2 AAAAAAAAAAAAAAAAAAAA']

NM_001077620.2(PRCD):c.2T> ['GGGAGGGGATGGGGCAGCTGCGCCAYGTGC

2252 C (p.MetlThr) -1 - ACCACCCTTTTCCTGCTCAGC]

NM_001142800.1(EYS):c.9209T 34600 ['AGCCACAAAGTTTTTATGTGGATCARTATCC

2253 >C (p.Ile3070Thr) 7 EYS TCGGAAAGAATTAGACTGTT']

NM_206933.2(USH2A):c.9751T ['TCCTAAATTGACAGGTGAAGTATGCYGTCCA

2254 >C (p.Cys3251Arg) 7399 USH2A GATGAACAGCACAATCGGGT']

NM_000257.3 (MYH7) :c.4442T> ['GAGGCTCGCTCCCTCAGCACAGAGCYCTTCA

2255 C (p.Leul481Pro) -1 - AACTCAAGAACGCCTATGAG]

NM_000257.3(MYH7):c.4835T> ['GAGACACGCAGCCGCAACGAGGCCCYGAGG

2256 C (p.Leul612Pro) -1 - GTGAAGAAGAAGATGGAAGGA]

NM_000257.3(MYH7):c.4937T> ['GAGGCCCAGAAGCAAGTCAAGAGCCYCCAG

2257 C (p.Leul646Pro) -1 - AGCTTGTTGAAGGTACTCACC]

NM 001199138 (NLRC4):c.10 ['AATCTCATGAAGACCCCTCTCTTTGYGGTCA

2258 22T>C (p.Val341Ala) 58484 NLRC4 TCACTTGTGCAATCCAGATG']

NM_000076.2(CDKNlC):c.*5+2 ['GCGCAAGAGGCTGCGGTGAGCCAAGYGAGT

2259 T>C 1028 CDKN1C ACAGCGCACCTGGGGGGGCGC]

NM_003159.2(CDKL5):c.659T> ['CCTGGAGAAAGTGAAATTGACCAACYTTTT

2260 C (p.Leu220Pro) 6792 CDKL5 ACTATTCAGAAGGTGCTAGGA]

NM_005027.3(PIK3R2):c. l202T ['CTCACCTTCTGCTCCGTTGTGGACCYCATCA

2261 >C (p.Leu401Pro) 5296 PIK3R2 ATCACTACCGCCACGAGTCT']

NM_173596.2(SLC39A5):c.911 28337 ['TTCCTGCTCTTTGTGCTGGAGAACAYGCTGG

2262 T>C (p.Met304Thr) 5 SLC39A5 GGCTTTTGCGGCACCGAGGG]

NM_153334.6(SCARF2):c.l90T ['CCTTGCTGCCTCCAGCCAGCGCAGCRCGTGG

2263 >C (p.Cys64Arg) 91179 SCARF2 GCACCTGGGAGCTGCGAGCA']

NM_001288767.1(ARMC5):c.l9 ['GGGGCACTTGTGACCGGCCCGGCGCYGTAC

2264 28T>C (p.Leu643Pro) 79798 ARMC5 GGCCTGCTGACCTATGTGACC]

NM_001288767.1(ARMC5):c.l3 ['CGTGAGGCCATCAACCGGGCCCGACYGCGG

2265 79T>C (p.Leu460Pro) 79798 ARMC5 GATGCTGGTGGCTTGGATCTA]

['ATAATCCTATTTATTACCTCAGAAGYTTTTTT

2266 NC_012920.1 :m.9478T>C 4514 MT-C03 CTTCGCAGGATTTTTCTGA']

['ACTAGTCACAGCCCTATACTCCCTCYACATA

2267 NC_012920.1 :m.11984T>C 4538 MT-ND4 TTTACCACAACACAATGGGG]

NM_014845.5(FIG4):c.50T>C ['ATCAGCTCGGTCCAGAAGCTGGTTCYGTATG

2268 (p.Leul7Pro) 9896 FIG4 AGACTAGAGCTGTGAGTACC]

NM_003159.2(CDKL5):c.145+2 ['TCAAGAAATTCAAGGACAGTGAAGGYAGAT

2269 T>C 6792 CDKL5 ATATATATATATATATATATA']

NM_002775.4(HTRAl):c.l091T ['CCATCTGATAAGATTAAAAAGTTCCYCACG

2270 >C (p.Leu364Pro) 5654 HTRA1 GAGTCCCATGACCGACAGGCC]

2271 NM_021870.2(FGG):c.l210T>C 2266 FGG ['ATCTTCATAGTGGTTTTCTTCATGGRATACC (p.Ser404Pro) ACCGGGTTTTCCAAGTGGCC]

NM_017617.3(NOTCHl):c. l285 ['TCGAAGGAGCCCAGCGTGTTGATGCRCTTGC

2272 T>C (p.Cys429Arg) 4851 NOTCH 1 CCGCATGCTCGCAGGGGTTG]

NM_024915.3 (GRHL2) :c .1192T ['GATGATTCAGATTGACACATACAGTYATAA

2273 >C (p.Tyr398His) 79977 GRHL2 CAATCGTAGCAATAAACCCAT']

NM_002049.3 (GAT Al ) :c .2T>C ['CGCAGGTTAATCCCCAGAGGCTCCAYGGAG

2274 (p.MetlThr) 2623 GATA1 TTCCCTGGCCTGGGGTCCCTG]

NM_002049.3 (GAT Al ) :c .1240T ['TACTGTGGTGGCTCCGCTCAGCTCAYGAGGG

2275 >C (p.Ter414Arg) 2623 GATA1 CACAGAGCATGGCCTCCAGA']

NM_005859.4(PURA):c.299T>C [' GGC GC GGGCGGC A AC A AG AGCC GCC YT ACT

2276 (p.LeulOOPro) 5813 PURA CTCTCCATGTCAGTGGCCGTG]

NM_032374.4(APOPTl):c.353T ['TTCTGGGCAAACCAGAATTTGACTTYTAGTA

2277 >C (p.Phel l8Ser) 84334 APOPTl AGGTAAGTTTAAGTTTTAGA']

NM_032551.4(KISSlR):c.937T> ['TAAGACCTGGGCTCACTGCATGTCCYACAGC

111% C (p.Tyr313His) 84634 KISS1R AACTCCGCGCTGAACCCGCT']

NM_017696.2(MCM9):c.1732+2 25439 ['AAAGCTTGATACGATTAGCAGAAGGYCTAT

2279 T>C 4 MCM9 TTCATTCAGCGAATGATGCTT']

NM_003159.2(CDKL5):c.602T> ['GACATGTGGTCGGTGGGCTGTATTCYTGGGG

2280 C (p.Leu201Pro) 6792 CDKL5 AGCTTAGCGATGGACAGCCT']

NM_005740.2(DNAL4):c.153+2 ['GAGAAATTCTCCAACAACAACGAGGYATTG

2281 T>C 10126 DNAL4 CCAGCAGTGCAGGCGGCCCCT']

NM_201631.3(TGM5):c.763T>C ['TTCAGGATGGCCACGCTGCCCGTCCRCTCCG

2282 (p.Trp255Arg) 9333 TGM5 CAGGGTTGGCGCCGTCTGTG]

NM_201631.3(TGM5):c. l22T>C ['GCTCCGGTTCCTGAAGTACAGGGTGRGGTTG

2283 (p.Leu41Pro) 9333 TGM5 AAGGCCTGGCCCCGGCGAAC]

NM_001287223.1(SCNl lA):c.3 ['TACCTTCATTCCTTCAAACTGGGACRGCGCA

2284 473T>C (p.Leul l58Pro) 11280 SCN11A CGAAGAGGCCTCAGTGCTCG]

NM_001287223.1(SCNl lA):c.l ['GGGCTCTACTCAGTCTTCTTCTTCAYTGTGG

2285 142T>C (p.Ile381Thr) 11280 SCN11A TCATTTTCCTGGGCTCCTTC]

NM_001302946.1(TRNTl):c.668 ['CATGATCCTGAGACTTTGGAAGCAAYTGCA

2286 T>C (p.Ile223Thr) 51095 TRNT1 GAAAATGCAAAAGGCTTGGCT']

NM_001302946.1(TRNTl):c.497 ['TAATGAATAGGTTTTGATGGCACTTYATTTG

2287 T>C (p.Leul66Ser) 51095 TRNT1 ACTACTTTAATGGTTATGAA']

NM_018136.4(ASPM):c.2419+2 25926 ['ATAGACACCTATGGAAAGATGTGGGYAAGA

2288 T>C 6 ASPM AGACTGCAGAAATCTTGACAT']

NM_022455.4(NSDl):c.5885T> ['TGGGGTCTACGGACAAAAACAGATAYTAAA

2289 C (p.Ilel962Thr) 64324 NSD1 AAGGTTAGAAAAAGCTAAATT']

NM_022455.4(NSDl):c.5989T> ['TCAAGAACATGATATCACTAATTTCYATATG

2290 C (p.Tyrl997His) 64324 NSD1 CTCACCCTAGACAAAGTAAG]

NM_133433.3(NIPBL):c.7062+2 ['AAAAAATATGCTGGATTCATTCATGYATGTA

2291 T>C 25836 NIPBL TTTTAACATTTTATAACCTA']

NM_000525.3(KCNJll):c.988T ['GGAGGACGGACGTTACTCTGTGGACYACTC

2292 >C (p.Tyr330His) 3767 KCNJ11 CAAGTTTGGCAACACCGTCAA']

2293 M_004004.5 (GJB2) :c .107T>C 2706 GJB2 ['CTCTTCATTTTTCGCATTATGATCCYCGTTGT (p.Leu36Pro) GGCTGCAAAGGAGGTGTGG]

NM_130838.1(UBE3A):c.2485T ['CTTTAATGTGCTTTTACTTCCGGAAYACTCA

2294 >C (p.Tyr829His) 7337 UBE3A AGCAAAGAAAAACTTAAAGA]

NM_005682.6(ADGRGl):c.l460 ['GCCATCTTCCTGCACTTCTCCCTGCYCACCT

2295 T>C (p.Leu487Pro) 9289 ADGRG1 GCCTTTCCTGGATGGGCCTC]

NM_000430.3(PAFAHlBl):c.84 PAFAHIB ['CCGAGAGCATGAGCATGTGGTAGAAYGCAT

2296 1T>C (p.Cys281Arg) 5048 1 TTCCTGGGCTCCAGAAAGCTC]

NM_001005360.2(DNM2):c.l86 ['GTGGACAGCTGGAAGGCCTCGTTCCYCCGA

2297 2T>C (p.Leu621Pro) 1785 DNM2 GCTGGCGTCTACCCCGAGAAG]

NM_178151.2(DCX):c.683T>C ['CTGGAGACCGGGGTTGTCAAAAAACYCTAC

2298 (p.Leu228Pro) 1641 DCX ACTCTGGATGGAAAACAGGTA']

NM_178151.2(DCX):c.641T>C ['TCTTTTGAGCAAGTCCTCACTGATAYCACAG

2299 (p.Ile214Thr) 1641 DCX AAGCCATCAAACTGGAGACC]

NM_178151.2(DCX):c.412T>C ['AGACAACTTCTTTAAAAAGGTGGAGYACAC

2300 (p.Tyrl38His) 1641 DCX CAAGAATGTCAATCCCAACTG]

NM_178151.2(DCX):c.272T>C ['TTGCTGGCTGACCTGACGCGATCTCYGTCTG

2301 (p.Leu91Pro) 1641 DCX ACAACATCAACCTGCCTCAG]

NM_178151.2(DCX):c.l28T>C ['TGTAGCTTCTACCGAACCAGAACCTYGCAG

2302 (p.Leu43Ser) 1641 DCX GCACTGAGTAATGAGAAGAAA']

NM_178151.2(DCX):c.2T>C ['AGGTCTCTGAGGTTCCACCAAAATAYGGAA

2303 (p.MetlThr) 1641 DCX CTTGATTTTGGACACTTTGAC]

NM_000252.2(MTMl):c.260T> ['TCTTCTCTAATACTTGATGTTCCTCYGGGTGT

2304 C (p.Leu87Pro) 4534 MTM1 GATCTCGAGAATTGAAAAA']

NM_000252.2(MTMl):c.683T> ['AACTTTCTGACTTAACCATAGGTGCYGTCAT

2305 C (p.Leu228Pro) 4534 MTM1 GGATTCATCCAGAAAATAAG]

NM_000252.2(MTMl):c.958T> ['TCATAATATTCATGTTATGCGGGAAYCTTTA

2306 C (p.Ser320Pro) 4534 MTM1 AAAAAAGTGAAGGACATTGT']

NM_000252.2(MTMl):c.1353+2 ['TGTGTGTGGCAAATGTCAAAACAGGYAAGG

2307 T>C 4534 MTM1 AATATGAGGGATGAAAATACA']

NM_000252.2(MTMl):c.l367T> ['GTTTTTGTTTAGTTCCCTACAGCTTYTGAATT

2308 C (p.Phe456Ser) 4534 MTM1 CAATGAACAATTTTTGATT']

NM_000252.2(MTMl):c.l433T> ['CTGTATAGTTGCCGATTTGGTACTTYCTTATT

2309 C (p.Phe478Ser) 4534 MTM1 CAACTGTGAATCTGCTCGA']

NM_000252.2(MTMl):c.l495T> ['GGTTACAGAAAGGACTGTTTCTTTAYGGTCA

2310 C (p.Trp499Arg) 4534 MTM1 CTGATAAACAGTAATAAAGA]

NM_006579.2(EBP):c.310T>C ['TCTCTTCTTTTCTTCAGGGAAAGAGYATGCC

2311 (p.Tyrl04His) 10682 EBP AAGGGAGACAGCCGATACAT']

NM_152296.4(ATPlA3):c.2270 ['GAGCCTGCCTGTGCCACAGGCCGCCYGATCT

2312 T>C (p.Leu757Pro) 478 ATP 1 A3 TCGACAACCTAAAGAAGTCC]

NM_152296.4(ATPlA3):c.l250 ['GTGGCCCTGTCTCACATCGCTGGGCYCTGCA

2313 T>C (p.Leu417Pro) 478 ATP 1 A3 ATCGCGCTGTCTTCAAGGGT']

NM_152296.4(ATPlA3):c.l l44 ['GAACCGCATGACAGTCGCCCACATGYGGTT

2314 T>C (p.Trp382Arg) 478 ATP 1 A3 TGACAACCAGATCCACGAGGC]

2315 NM_152296.4(ATPlA3):c.l l l2 478 ATP 1 A3 ['ATCTGCTCAGATAAGACAGGGACCCYCACT T>C (p.Leu371Pro) CAGAACCGCATGACAGTCGCC]

NM_004963.3(GUCY2C):c.2782 ['CTTTCTGTCCTTCATTTCAGGTCCCYGTGCTG

2316 T>C (p.Cys928Arg) -1 - CTGGAGTTGTGGGAATCAA']

NM_000109.3 (DMD) :c .1700T> ['GTTCACTGCATCTTCTTTTTCTGAARGCCATG

2317 C (p.Leu567Pro) 1756 DMD CACTAAAAAGGCACTGCAA']

NM_001543.4(NDSTl):c.l918T ['CAGCAACTACCCCAGCTCTGAGACCYTTGA

2318 >C (p.Phe640Leu) 3340 NDST1 GGAGATCCAGTTTTTTAATGG]

NM_001999.3(FBN2):c.3740T> ['GGTGTCACAGCCTCCGTTCATTATCRTACAT

2319 C (p.Metl247Thr) 2201 FBN2 TCATCAATATCTGTGAAAAC]

NM_005154.4(USP8):c.2152T> ['ACCTTCCAAACTGAAGCGCTCCTACYCCTCC

2320 C (p.Ser718Pro) 9101 USP8 CCAGATATAACCCAGGCTAT']

NM_000734.3 (CD247) :c.2T>C ['CCTCTTTCTGAGGGAAAGGACAAGAYGAAG

2321 (p.MetlThr) 919 CD247 TGGAAGGCGCTTTTCACCGCG]

NM_000663.4(ABAT):c.l433T> ['AAATCCATTCGTTTCCGTCCCACGCYGGTCT

2322 C (p.Leu478Pro) 18 ABAT TCAGGGATCACCACGCTCAC]

NM_005211.3(CSFlR):c.2717T> ['ACCCACAGACCCACCTTCCAGCAGAYCTGCT

2323 C (p.Ile906Thr) 1436 CSF1R CCTTCCTTCAGGAGCAGGCC]

NM_005211.3(CSFlR):c.2566T> ['CTTGGCCTTTGCAGGGCTGAATCCCYACCCT

2324 C (p.Tyr856His) 1436 CSF1R GGCATCCTGGTGAACAGCAA']

NM_005211.3(CSFlR):c.2480T> ['GTGAAGTGGATGGCCCCAGAGAGCAYCTTT

2325 C (p.Ile827Thr) 1436 CSF1R GACTGTGTCTACACGGTTCAG]

NM_005211.3(CSFlR):c.2450T> ['TGGGGACTGTCATCCCAGGCCCGCCYGCCTG

2326 C (p.Leu817Pro) 1436 CSF1R TGAAGTGGATGGCCCCAGAG]

NM_005211.3(CSFlR):c.l957T> ['GAACATCGTCAACCTTCTGGGAGCCYGTACC

2327 C (p.Cys653Arg) 1436 CSF1R CATGGAGGTAAGGGCCTTGG]

NM_005211.3(CSFlR):c.l745T> ['AAGTGGGAGTTCCCCCGGAACAACCYGCAG

2328 C (p.Leu582Pro) 1436 CSF1R TTTGGTGAGATGGCAGCTCAT']

NM_001563.3(IMPGl):c.461T> ['AATTCCCAGGAGCACCTGGATCTTCYCCAGC

2329 C (p.Leul54Pro) 3617 IMPG1 AGGTGAGCCTAAACACCACA']

NM_001130823.1(DNMTl):c.l5

31T>C (p.Tyr511His) 1786 DNMT1 []

NM_152515.4(CKAP2L):c.2T>C 15046 ['AGCAGCGGTAGGCCCGGGCCCCACCRTGAC

2330 (p.MetlThr) 8 CKAP2L TCTTCAGTGACAGTTTTTCTT']

NM_170707.3(LMNA):c.1968+2 ['GGCAACTCCAGCCCCCGAACCCAGGNGAGT

2331 T>C 4000 LMNA TGTCTCTGCTTTGTCTCCAAA']

NM_153818.1(PEX10):c.890T> ['AGAAACCCCCTGTGCACCCTGTGCCYGGAG

2332 C (p.Leu297Pro) 5192 PEX10 GAGCGCAGGCACCCAACAGCC]

NM_153818.1(PEX10):c.2T>C ['TCGGGACCACCCGAACCCGCGGCCAYGGCC

2333 (p.MetlThr) 5192 PEX10 CCGGCCGCCGCCAGCCCCCCG]

NM_014305.3(TGDS):c.700T>C ['AATGCTTCTACAACATCAGTAGCATRAAGG

2334 (p.Tyr234His) 23483 TGDS AAGTTTCTTGTTTGAAGCCCT']

NM_000256.3(MYBPC3):c2994 ['GTGAACCTTCTCATCCCTTTCCAGGYGGGAC

2335 +2T>C 4607 MYBPC3 TGGCCCCCTTCCCTGTCCCC]

2336 NM_000256.3(MYBPC3):c.l624 4607 MYBPC3 ['CTCATGTGCCCCCCCAGCCAGGCTCDCCCTG +2T>C CACAATGAGCTCAGCCAGCG]

NM_000257.3 (MYH7) :c.2207T> ['GCGGCCATCCCTGAGGGACAGTTCAHTGAT

2337 C (p.Ile736Thr) 4625 MYH7 AGCAGGAAGGGGGCAGAGAAG]

NM_000138.4(FBNl):c.7754T> ['TGCCAGCATGGCTGCCAGAACATCAYTGGG

2338 C (p.Ile2585Thr) 2200 FBN1 GGCTACAGGTGCAGCTGCCCC]

NM_000371.3 (TTR) :c .190T>C ['GGCTGCTGATGACACCTGGGAGCCAYTTGC

2339 (p.Phe64Leu) 7276 TTR CTCTGGGTAAGTTGCCAAAGA']

NM_000126.3 (ETF A) : c.2T>C ['GAGGTTGCGGCGGAAGCGGAGACCAYGTTC

2340 (p.MetlThr) 2108 ETFA CGAGCGGCGGCTCCGGGGCAG]

NM_006493.2(CLN5):c.2T>C ['GCGGGCCGGGCGCGGGGAGGTGTCAYGCGC

2341 (p.MetlThr) 1203 CLN5 CGGAACCTGCGCTTGGGGCCA]

NM_000543.4(SMPDl):c.475T> ['CTCAGTGCTGAGCCCATCTGAGGCCYGTGGC

2342 C (p.Cysl59Arg) 6609 SMPD1 CTGCTCCTGGGCTCCACCTG]

NM_000501.3(ELN):c.889+2T> ['TTCCTGGAATTGGAGGCATCGCAGGYAACA

2343 C 2006 ELN TCTGTCCCAGCAGGGGGCGGG]

NM_000169.2(GLA):c.758T>C ['TGGACATCTTTTAACCAGGAGAGAAYTGTTG

2344 (p.Ile253Thr) -1 - ATGTTGCTGGACCAGGGGGT']

NM_152743.3(BRATl):c.l76T> 22192 ['GAGCACCCCTGCCTGGTGGAGCTGCYGTCCC

2345 C (p.Leu59Pro) 7 BRAT1 ATGTGCTGAAAGTCCAGGAC]

NM_000152.3 (GAA) :c .896T>C ['CTCTACGGGTCTCACCCTTTCTACCBGGCGC

2346 (p.Leu299Pro) 2548 GAA TGGAGGACGGCGGGTCGGCA]

NM_015384.4(NIPBL):c.7637T> ['AATGTGTCCCAGGGTATTTTATTACYTCTCA

2347 C (p.Leu2546Pro) 25836 NIPBL TGTTAAAACAACATTTGAAG]

NM_005641.3(TAF6):c.212T>C ['ATTCTTTAGCTTCAAGGCGTAGTCADTGTCA

2348 (p.Ile71Thr) 6878 TAF6 CTGGTGGTGAGCTTCTGCCG']

NM_170707.3(LMNA):c.710T> ['ATTGACAATGGGAAGCAGCGTGAGTYTGAG

2349 C (p.Phe237Ser) 4000 LMNA AGCCGGCTGGCGGATGCGCTG]

NM_000527.4(LDLR):c.l468T> ['GGACTGGATCCACAGCAACATCTACYGGAC

2350 C (p.Trp490Arg) 3949 LDLR CGACTCTGTCCTGGGCACTGT']

NM_000081.3 (LYST) :c.772T>C ['CATGAACAATTCTCCATTTGACTTAYGTCAT

2351 (p.Cys258Arg) 1130 LYST GTTTTGTTATCTTTATTAGA]

NM_000256.3(MYBPC3):c3796 ['CTTACAGGGCGAGGCACGGTGTGAGYGCCG

2352 T>C (p.Cysl266Arg) 4607 MYBPC3 CCTGGAGGTGCGAGGTGAGGA']

NM_000256.3(MYBPC3):c.3713 ['TTCAGCAAGCAGGGAGTGTTGACTCYGGAG

2353 T>C (p.Leul238Pro) 4607 MYBPC3 ATTAGAAAGCCCTGCCCCTTT']

NM_000256.3(MYBPC3):c.3330 ['CAGAAAGCCGACAAGAAGACCATGGBGAGC

2354 +2T>C 4607 MYBPC3 CCAGGGTCTGGGGTCCCCACG]

NM_000256.3(MYBPC3):c.l696 ['CGCAAAGGACCAGGCGGTGTTCAAAYGTGA

2355 T>C (p.Cys566Arg) 4607 MYBPC3 GGTCTCAGATGAGAATGTTCG]

NM_000256.3(MYBPC3):c.l456 ['ATCGGAGGAGGGGGCGCAAGTCAAABGGTG

2356 T>C (p.Trp486Arg) 4607 MYBPC3 AGTTCCAGAAGCACGGGGCAT']

NM_000256.3(MYBPC3):c.709T ['TGCCCAGCCTGCCTTCACTGGCAGCYACCGC

2357 >C (p.Tyr237His) 4607 MYBPC3 TGTGAGGTGTCCACCAAGGA']

2358 NM_000256.3(MYBPC3):c.467T 4607 MYBPC3 ['GGAGCCCCCGATGACCCCATTGGCCYCTTCG >C (p.Leul56Pro) TGATGCGGCCACAGGATGGC]

NM_000257.3(MYH7):c.2723T> ['GATGCTGAGGAGCGCTGTGATCAGCYGATC

2359 C (p.Leu908Pro) 4625 MYH7 AAAAACAAGATTCAGCTGGAG]

NM_000257.3 (MYH7) :c.2479T> ['TCGGGCCTTCATGGGGGTCAAGAATYGGCC

2360 C (p.Trp827Arg) 4625 MYH7 CTGGATGAAGCTCTACTTCAA']

NM_000257.3(MYH7):c.l400T> ['GTCCTGGACATCGCTGGCTTCGAGAYCTTCG

2361 C (p.Ile467Thr) 4625 MYH7 ATGTGAGTTGGGACCCCTGG]

NM_000257.3(MYH7):c.l048T> ['CACTTCAGAGGAGAAAAACTCCATGYATAA

2362 C (p.Tyr350His) 4625 MYH7 GCTGACAGGCGCCATCATGCA']

NM_000257.3(MYH7):c.730T> ['CGTCCGGAACGACAACTCCTCCCGCYTCGTG

2363 C (p.Phe244Leu) 4625 MYH7 AGTGGTCCCTGACCTTGGCC]

NM_005159.4(ACTCl):c.755T> ['CTGCCTGATGGCCAAGTCATCACTAYTGGCA

2364 C (p.Ile252Thr) -1 - ATGAGCGCTTCCGCTGTCCT']

NM_030662.3(MAP2K2):c. l69T ['GCAGCAGAAGAAGCGGCTGGAAGCCNTTCT

2365 >C (p.Phe57Leu) 5605 MAP2K2 CACCCAGAAAGCCAAGGTCGG]

NM_000169.2(GLA):c.41T>C ['CCAGAACTACATCTGGGCTGCGCGCYTGCG

2366 (p.Leul4Pro) -1 - CTTCGCTTCCTGGCCCTCGTT']

NM_002294.2(LAMP2):c.864+2 ['TATCTAGACTTTGTCTTTGCTGTGGYGAGTA

2367 T>C 3920 LAMP2 ACAGATTTTTTAAAGTTAGG]

NM_000551.3 (VHL) : c.227T>C ['TCGCGCGAGCCCTCCCAGGTCATCTYCTGCA

2368 (p.Phe76Ser) 7428 VHL ATCGCAGTCCGCGCGTCGTG]

NM_000551.3 (VHL) : c.266T>C ['CCGCGCGTCGTGCTGCCCGTATGGCHCAACT

2369 (p.Leu89Pro) 7428 VHL TCGACGGCGAGCCGCAGCCC]

NM_000551.3 (VHL) : c.473 T>C ['GTTTTTGCCCTTCCAGTGTATACTCHGAAAG

2370 (p.Leul58Pro) 7428 VHL AGCGATGCCTCCAGGTTGTC]

NM_000051.3(ATM):c.8584+2T ['GCAGTGTAGCTACTTCTTCTATTGGYAATCT

2371 >C -1 - TCTTGTACATATAGTAGATT']

NM_058216.2(RAD51C):c.404+ ['AGGTGTTGGAAAAACACAATTATGGYAAAA

2372 2T>C 5889 RAD51C TAAAGTGTTCTCCTTTTAAGG]

NM_000455.4(STKl l):c.545T> ['CACAAGGACATCAAGCCGGGGAACCYGCTG

2373 C (p.Leul82Pro) 6794 STK11 CTCACCACCGGTGGCACCCTC]

NM_001199107.1(TBClD24):c. ['GGACAACACGCAGGTGCCCAGCTACYGCCT

2374 313T>C (p.Cysl05Arg) 57465 TBC1D24 GAATGCACGCGGCGAGGGGGC]

NM_000899.4(KITLG):c.98T>C ['ACTGAAGGGATCTGCAGGAATCGTGYGACT

2375 (p.Val33Ala) 4254 KITLG AATAATGTAAAAGACGTCACT']

NM_001195129.1(PRSS56):c.l l 64696 ['GCAGTGCCTGCAGCGCCGGCGGCGAYGCGG

2376 83T>C (p.Cys395Arg) 0 PRSS56 TCAGTTCTGTTCACCCGGACC]

NM_006888.4(CALMl):c.268T> ['TAGTGAAGAAGAAATCCGTGAGGCAYTCCG

2377 C (p.Phe90Leu) 801 CALM1 AGTCTTTGACAAGGTAATCCA']

NM_017534.5(MYH2):c.5609T> ['GAAGATAGAAAGAATATTCTCAGGCYTCAA

2378 C (p.Leul870Pro) -1 - GATTTGGTAGATAAACTTCAG]

NM_003000.2(SDHB):c.574T>C ['CTACGAGTGCATTCTCTGTGCCTGCYGTAGC

2379 (p.Cysl92Arg) 6390 SDHB ACCAGCTGCCCCAGCTACTG]

2380 NM_000314.6(PTEN):c.406T>C 5728 PTEN ['AAAGGGACGAACTGGTGTAATGATAYGTGC (p.Cysl36Arg) ATATTTATTACATCGGGGCAA]

NM_000051.3(ATM):c.2T>C ['ATGTGTGTTCTGAAATTGTGAACCAYGAGTC

2381 (p.MetlThr) 472 ATM TAGTACTTAATGATCTGCTT']

NM_052867.2(NALCN):c.l526T 25923 ['GGTCCTGGAAAAAAGCTTGGGAGTTYGGTT

2382 >C (p.Leu509Ser) 2 NALCN GTATTTACTGCCAGCCTCTTG]

NM_000314.6(PTEN):c.545T>C ['TATGTGTATTATTATAGCTACCTGTYAAAGA

2383 (p.Leul82Ser) 5728 PTEN ATCATCTGGATTATAGACCA']

NM_005957.4(MTHFR):c. l969T ['ACGCAGGGCGTCAGGACGCAGGGTCRTGGA

2384 >C (p.Ter657Arg) 4524 MTHFR GCCTCCGTTTCTCTCGCATTC]

NM_005957.4(MTHFR):c. l883T ['AACCTGGTGGACAATGACTTCCCACYGGAC

2385 >C (p.Leu628Pro) 4524 MTHFR AACTGCCTCTGGCAGGTGGTG]

NM_005957.4(MTHFR):c.1793T ['CTGTGGATTGAGCGGTGGGGAAAGCYGTAT

2386 >C (p.Leu598Pro) 4524 MTHFR GAGGAGGAGTCCCCGTCCCGC]

NM_005957.4(MTHFR):c. l530+ ['AGCGGGGGCTATGTCTTCCAGAAGGYGTGG

2387 2T>C 4524 MTHFR TAGGGAGGCACGGGGTGCCCC]

NM_005957.4(MTHFR):c.388T> ['CCTGGAGACCATCCTGCACATGACCYGCTGC

2388 C (p.Cysl30Arg) 4524 MTHFR CGTCAGCGCCTGGAGGAGAT']

NM_000264.3 (PTCH 1 ) : c.3168+2 ['AACCCCTGGACGGCCGGGATCATTGYGAGT

2389 T>C 5727 PTCH1 GTATTATAAGGGGCTTTGTGG]

NM_000030.2(AGXT):c.302T>C ['GTGCTGGAGCCTGGGGACTCCTTCCYGGTTG

2390 (p.LeulOlPro) 189 AGXT GGGCCAATGGCATTTGGGGG]

NM_000030.2(AGXT):c.322T>C ['CTTCCTGGTTGGGGCCAATGGCATTYGGGGG

2391 (p.Trpl08Arg) 189 AGXT CAGCGAGCCGTGGACATCGG]

NM_000023.2(SGCA):c.371T>C ['ACTCGGCAGAGGCTGGTGCTGGAGAYTGGG

2392 (p.Ilel24Thr) 6442 SGCA GACCCAGAAGGTACCTCTAGC]

NM_016035.4(COQ4):c. l55T>C ['CGCCATCGCCGCGGAGCCGGCGGCCRACAG

2393 (p.Leu52Ser) 51117 COQ4 CCCTTTCTGCAGCGGGGAGGT']

NM_000510.2(FSHB):c.298T>C ['GTATACATACCCAGTGGCCACCCAGYGTCA

2394 (p.CyslOOArg) 2488 FSHB CTGTGGCAAGTGTGACAGCGA']

NM_007374.2(SIX6):c.l l0T>C ['CGCCTGGGTCGCTTCCTCTGGTCGCYGCCCG

2395 (p.Leu37Pro) 4990 SIX6 TGGCCCCTGCGGCCTGCGAG]

NM_000314.6(PTEN):c.202T>C ['AAAGCATAAAAACCATTACAAGATAHACAA

2396 (p.Tyr68His) 5728 PTEN TCTGTAAGTATGTTTTCTTAT']

NM_001103.3(ACTN2):c.683T> ['GAGAAGCACCTGGATATTCCTAAAAYGTTG

2397 C (p.Met228Thr) 88 ACTN2 GATGCTGAAGGTGAGATGAAA']

NM_005249.4(FOXGl):c.700T> ['GCAGAACTCCATCCGCCACAATCTGYCCCTC

2398 C (p.Ser234Pro) 2290 FOXG1 AACAAGTGCTTCGTGAAGGT']

NM_001165963.1(SCNlA):c.40 ['ATTCCATCCATCATGAATGTGCTTCYGGTTT

2399 55T>C (p.Leul352Pro) -1 - GTCTTATATTCTGGCTAATT']

NM_001165963.1(SCNlA):c.26 ['GCTCTGGGAAATTTAACCCTCGTCTYGGCCA

2400 90T>C (p.Leu897Ser) 6323 SCN1A TCATCGTCTTCATTTTTGCC]

NM_001165963.1(SCNlA):c. l2 ['CTAATAAATTTGATCCTGGCTGTGGHGGCCA

2401 65T>C (p.Val422Ala) 6323 SCN1A TGGCCTACGAGGAACAGAAT']

2402 NM_001165963.1(SCNlA):c. lO 6323 SCN1A ['TTTCTTTTACCCCACTTGCAGCCAAYGTCCA 33T>C (p.Cys345Arg) GAGGGATATATGTGTGTGAA]

NM_001165963.1(SCNlA):c.76 ['AGATGTAATGATCCTGACTGTGTTCYGTCTG

2403 9T>C (p.Cys257Arg) 6323 SCN1A AGCGTATTTGCTCTAATTGG]

NM_001165963.1(SCNlA):c.32 ['TTCCGGTTCAGTGCCACCTCTGCCCYGTACA

2404 3T>C (p.Leul08Pro) 6323 SCN1A TTTTAACTCCCTTCAATCCT']

NM_000426.3(LAMA2):c.8282T ['GCAGAATCAGAACCAGCTCTTTTGAYAGGG

2405 >C (p.Ile2761Thr) 3908 LAMA2 AGCAAGCAGTTCGGGCTTTCA']

NM_001199.3(BMPl):c.*241T> ['GTCTGTGACATTTCCTGTTGTGAAGYAAAAG

2406 C 649 BMP1 AGGGACCCCTGCGTCCTGCT']

NM_001987.4(ETV6):c.l046T> ['CTTTGGGATTACGTCTATCAGTTGCYTTCTG

2407 C (p.Leu349Pro) 2120 ETV6 ACAGCCGGTACGAAAACTTC]

M_004974.3(KCNA2):c.788T> ['ATGAACATCATTGACATTGTGGCCAYCATCC

2408 C (p.Ile263Thr) 3737 KCNA2 CCTACTTCATCACCCTGGGG]

NM_002055.4(GFAP):c.791T>C ['GTGTCCCCCACCTAGTTTGCAGACCYGACAG

2409 (p.Leu264Pro) 2670 GFAP ACGCTGCTGCCCGCAACGCG]

NM_002055.4(GFAP):c.239T>C ['GAGATGATGGAGCTCAATGACCGCTYTGCC

2410 (p.Phe80Ser) 2670 GFAP AGCTACATCGAGAAGGTTCGC]

NM_002055.4(GFAP):c.218T>C ['ACCCGGGCCAGTGAGCGGGCAGAGADGATG

2411 (p.Met73Thr) 2670 GFAP GAGCTCAATGACCGCTTTGCC]

NM_001288953.1(TTC7A):c.l91 ['TTTGCCTGATGCCCATGATGCAGACYCTGGT

2412 2T>C (p.Ser638Pro) 57217 TTC7A AAGAACGAGCTCCTTGGGCC]

NM_000257.3(MYH7):c.5117T> ['TCCCGGAAGCTGGCGGAGCAGGAGCYGATT

2413 C (p.Leul706Pro) -1 - GAGACTAGTGAGCGGGTGCAG]

NM_000257.3 (MYH7) :c.4772T> ['ATGGAACAGGCCAAGCGCAACCACCWGCG

2414 C (p.Leul591Pro) -1 - GGTGGTGGACTCGCTGCAGACC]

NM_016218.2(POLK):c.609T>C ['TGAGTCTTGATGAAGCCTACTTGAAYATAAC

2415 (p.Asn203=) 51426 POLK AAAGCACTTAGAAGAAAGAC]

['TATTTTATAATCAATGAATTTGTTCYTTCTGA

2416 NM_016218.2(POLK):c.*66T>C 51426 POLK TTTTAAGTTTGCAGATTTA']

NM_015662.2(IFT172):c.770T> ['AGTCCTGGGGGCCAGTCTGTTGTGCYAGGA

2417 C (p.Leu257Pro) 26160 IFT172 AGTTATGACAGGTAAGTCCCC]

NM_178454.4(DRAM2):c.79T> 12833 ['GACATCTGCTGCTTTCATATTTTCAYACATT

2418 C (p.Tyr27His) 8 DRAM2 ACTGCAGTAACACTCCACCA']

NM_032790.3(ORAIl):c.581T> ['CTCTTCCTAGCTGAGGTGGTGCTGCYCTGCT

2419 C (p.Leul94Pro) 84876 OR All GGGTCAAGTTCTTGCCCCTC]

NM_001135669.1(XPRl):c.434T ['GAGTTCTACCTCAGTCTAATCCTGCYGCAGA

2420 >C (p.Leul45Pro) 9213 XPR1 ACTATCAGGTACTTAGATTC]

NM_001135669.1(XPRl):c.419T ['AAACTGGCCTTCAGTGAGTTCTACCYCAGTC

2421 >C (p.Leul40Pro) 9213 XPR1 TAATCCTGCTGCAGAACTAT']

NM_001135669.1(XPRl):c.653T ['GACAGACAAAAGGCTATGAAGCGTTYACGT

2422 >C (p.Leu218Ser) 9213 XPR1 GTCCCCCCTTTGGGAGCTGCT']

NM_005859.4(PURA):c.218T>C ['CGGGTGGACATCCAGAACAAGCGCTYCTAC

2423 (p.Phe73Ser) 5813 PURA CTGGACGTGAAGCAGAACGCC]

2424 NM_005859.4(PURA):c.563T>C 5813 PURA ['CTGGGCTCCACGCAGGGCCAGACCAYTGCG (p.Ilel88Thr) CTGCCCGCGCAGGGGCTCATC]

NM_001399.4(ED A) :c .396+2T> ['TCTGACTCCCAGGACGGGCACCAGGKGAGT

2425 C 1896 EDA CACCTAGTAGGGGCGGCGGCG]

NM_001848.2(COL6Al):c.957+ ['TCCAGGGGACCCAAGGGCTACAAGGYGAGC

2426 2T>C 1291 COL6A1 GTGGGCTGCTGGGAGGGGGGA']

M_000454.4(SODl):c.341T>C ['TCACTCTCAGGAGACCATTGCATCAYTGGCC

2427 (p.Ilell4Thr) 6647 SOD1 GCACACTGGTGGTAAGTTTT']

NM_020451.2(SEPNl):c.872+2T ['CTTCTACTACACTGTGATGTTCCGGYGAGTG

2428 >C 57190 SEPN1 GGCCACACTGGCTGGCCTGG]

M_004453.3(ETFDH):c.l001T ['GGTCTAGACTATCAGAATCCATACCYGAGTC

2429 >C (p.Leu334Pro) 2110 ETFDH CATTTAGAGAGTTCCAAAGG]

NM_198056.2(SCN5A):c.4299+ ['CAGCTGTGGACTCCAGGGGGGTAGGYTGCC

2430 6T>C 6331 SCN5A ACAGTGGCTTCTTCCACCAAG]

NM_198056.2(SCN5A):c.2291T ['TTCACAGGGATTTTCACAGCAGAGABGACCT

2431 >C (p.Met764Thr) 6331 SCN5A TCAAGATCATTGCCCTCGAC]

NM_198056.2(SCN5A):c.2047T ['AGAGTTAGAGGAGTCTCGCCACAAGBGTCC

2432 >C (p.Cys683Arg) 6331 SCN5A ACCATGCTGGAACCGTCTCGC]

M_004415.2(DSP):c.4961T>C ['GAAAAGCAGAGGACCCAGGAAGAGCYGAG

2433 (p.Leul654Pro) 1832 DSP GAGGCTCTCTTCTGAGGTCGAG]

NM_000238.3(KCNH2):c.2396T ['CGGGGCGACGTCGTCGTGGCCATCCYGGGT

2434 >C (p.Leu799Pro) 3757 KCNH2 ATGGGGTGGGGGGCGGGCACT']

NM_000238.3(KCNH2):c.2366T ['TTCATCTCCCGGGGCTCCATCGAGAYCCTGC

2435 >C (p.Ile789Thr) 3757 KCNH2 GGGGC G AC GTC GTC GTGGC C]

NM_000238.3(KCNH2):c. l945+ ['CTGCGTCATGCTCATTGGCTGTGAGYGTGCC

2436 6T>C 3757 KCNH2 CAGGGGCGGGCGGCGGGGAG]

NM_000238.3(KCNH2):c. l918T ['TCCCAACACCAACTCAGAGAAGATCBTCTCC

2437 >C (p.Phe640Leu) 3757 KCNH2 ATCTGCGTCATGCTCATTGG]

NM_000238.3 (KCNH2) : c.1282T ['CTACACGGCTGTCTTCACACCCTACYCGGCT

2438 >C (p.Ser428Pro) 3757 KCNH2 GCCTTCCTGCTGAAGGAGAC]

NM_000238.3(KCNH2):c. l25T> ['GCTCGGGTGGAGAACTGCGCCGTCAHCTAC

2439 C (p.Ile42Thr) 3757 KCNH2 TGCAACGACGGCTTCTGCGAG]

NM_000218.2(KCNQl):c. l025T ['GTCTTTGCCATCTCCTTCTTTGCGCYCCCAGC

2440 >C (p.Leu342Pro) 3784 KCNQ1 GGTAGGTGCCCCGTGGGTG]

NM_000218.2(KCNQl):c. l251+ ['CCCAAACCCAAGAAGTCTGTGGTGGYGAGT

2441 2T>C 3784 KCNQ1 AGCCCACCTGCCACCAGGGCA']

NM_130799.2(MENl):c.547T>C ['CCTCGCCCTGTCTGAGGATCATGCCYGGGTA

2442 (p.Trpl83Arg) 4221 MEN1 GTGTTTGGGCCCAATGGGGA']

NM_000138.4(FBNl):c.7531T> ['CACCATTGGCGGCTTCACATGCAAAYGTCCT

2443 C (p.Cys2511Arg) 2200 FBN1 CCCGGATTTACCCAACACCA']

NM_000138.4(FBNl):c.7111T> ['ATGCTGCTGTGACGGAGGGAGAGGCYGGGG

2444 C (p.Trp2371Arg) 2200 FBN1 TCCCCACTGTGAGATCTGCCC]

NM_000138.4(FBNl):c.6274T> ['CTGCTGTGCCTTGAAGGGAGAAGGCYGGGG

2445 C (p.Trp2092Arg) 2200 FBN1 AGACCCCTGCGAGCTCTGCCC]

2446 NM_000138.4(FBNl):c.5746T> 2200 FBN1 ['CACAATTGGTTCCTTCAACTGCCGCYGCAAT C (p.Cysl916Arg) CATGGTTTCATCCTTTCTCA]

NM_000138.4(FBNl):c.5726T> ['GGGAATGGAACTTGCCGGAACACAAYTGGT

2447 C (p.Ilel909Thr) 2200 FBN1 TCCTTCAACTGCCGCTGCAAT']

NM_000138.4(FBNl):c.l468+2T ['TGGACCTCCGTGGGGAGTGTATTGGYACGT

2448 >C 2200 FBN1 GATCCATCCTAGGTTGGCACC]

NM_004572.3(PKP2):c.2386T> ['TCTCATTGAAACTACAGCCTCTGCCYGTTAC

2449 C (p.Cys796Arg) 5318 PKP2 ACATTGAACAACATAATCCA']

NM_004333.4(BRAF):c. l783T> ['AGACCTCACAGTAAAAATAGGTGATYTTGG

2450 C (p.Phe595Leu) 673 BRAF TCTAGCTACAGTGAAATCTCG]

NM_000543.4(SMPDl):c.416T> ['GCCGTGTGCCAATCCATTGTCCACCYCTTTG

2451 C (p.Leul39Pro) 6609 SMPD1 AGGATGACATGGTGGAGGTG]

NM_000016.5(ACADM):c.698T ['GAAGCAGATACCCCAGGAATTCAGAHTGGG

2452 >C (p.Ile233Thr) 34 ACADM AGAAAGGTAAAGTATTTATTA]

M_004453.3(ETFDH):c.l852T ['AGGAGGACCTGCTTACAATGGAATGYAAAC

2453 >C (p.Ter618Gln) 2110 ETFDH TGCAGCTAGCCAGTTTCTTTC]

NM_000255.3 (MUT):c.842T>C ['GCCATTCTGGAGCTGGCCTATACTTYAGCAG

2454 (p.Leu281Ser) 4594 MUT ATGGATTGGAGTACTCTAGA']

NM_000277.1 (PAH) : c.2T>C [' AGACCTC ACTCCCGGGGAGCCAGCAB GTCC

2455 (p.MetlThr) 5053 PAH ACTGCGGTCCTGGAAAACCCA]

NM_000017.3(ACADS):c.l057T ['GGCAGCCATGGCCAAGCTGGCCGCCYCGGA

2456 >C (p.Ser353Pro) 35 ACADS GGCCGCGACCGCCATCAGCCA']

NM_002225.3(IVD):c.295+2T> ['GCGTATTGGGCATCACAGCCCCTGGYGAGT

2457 C 3712 IVD ATAGTGTCTTTCCCTAAAAAG]

NM_000030.2(AGXT):c.2T>C ['CGAGCGGCAGGTTGGGTGCGGACCAYGGCC

2458 (p.MetlThr) 189 AGXT TCTCACAAGCTGCTGGTGACC]

NM_000030.2(AGXT):c.77T>C ['CTCTCCATCCCCAACCAGCTCCTGCYGGGGC

2459 (p.Leu26Pro) 189 AGXT CTGGTCCTTCCAACCTGCCT']

NM_000030.2(AGXT):c.449T>C ['GGCCTGGCCCAGCACAAGCCAGTGCYGCTG

2460 (p.Leul50Pro) 189 AGXT TTCTTAACCCACGGGGAGTCG]

NM_000030.2(AGXT):c.497T>C ['TCGTCCACCGGCGTGCTGCAGCCCCHTGATG

2461 (p.Leul66Pro) 189 AGXT GCTTCGGGGAACTCTGCCAC]

NM_000030.2(AGXT):c.661T>C ['CGCCCCTCCAGGGACCTCGCTCATCYCCTTC

2462 (p.Ser221Pro) 189 AGXT AGTGACAAGGCCAAGTGAGT']

NM_000030.2(AGXT):c.757T>C ['CAAGTGGCTGGCCAACTTCTGGGGCYGTGA

2463 (p.Cys253Arg) 189 AGXT CGACCAGCCCAGGATGTGAGG]

NM_000030.2(AGXT):c.806T>C ['CATCACACAATCCCCGTCATCAGCCYGTACA

2464 (p.Leu269Pro) 189 AGXT GCCTGAGAGAGAGCCTGGCC]

NM_000030.2(AGXT):c.851T>C ['CCAGCGCCATCTCCCACACAGGGCCYGGAG

2465 (p.Leu284Pro) 189 AGXT AACAGCTGGCGCCAGCACCGC]

NM_000030.2(AGXT):c.893T>C ['CAGCACCGCGAGGCCGCGGCGTATCYGCAT

2466 (p.Leu298Pro) 189 AGXT GGGCGCCTGCAGGCACTGGGG]

NM_000030.2(AGXT):c.947T>C ['TGAGCCAGGCCCCTCCTGCAGGCGCYCCGG

2467 (p.Leu316Pro) 189 AGXT CTTCCCACAGTCACCACTGTG]

2468 NM_000030.2(AGXT):c.l076T> 189 AGXT ['AGCCCGCCCTGTGCCCCCCAGGTGCYGCGG C (p.Leu359Pro) ATCGGCCTGCTGGGCTGCAAT']

NM_000030.2(AGXT):c.l l51T> ['GTGACGGAGGCCCTGAGGGCGGCCCYGCAG

2469 C (p.Leu384Pro) 189 AGXT CACTGCCCCAAGAAGAAGCTG]

NM_012203.1(GRHPR):c.203T> [TCCGACCACGTGGACAAGAGGATCCYGGAT

2470 C (p.Leu68Pro) 9380 GRHPR GCTGCAGGTGCACACTGGGTG]

NM_012203.1(GRHPR):c.965T> ['CTGGCTGGCCTGAGAGGGGAGCCGAB GCCT

2471 C (p.Met322Thr) 9380 GRHPR AGTGAACTCAAGCTGTAGCCA']

NM_138413.3(HOGAl):c.533T> 11281 ['GTCCCAGCCAACACAGGGCTGGACCYGCCT

2472 C (p.Leul78Pro) 7 HOGA1 GTGGATGCAGTGGTCACGCTT]

NM_138413.3(HOGAl):c.875T> 11281 ['GGGATCCCAGGGCTGAAGAAAATCAYGGAC

2473 C (p.Met292Thr) 7 HOGA1 TGGTTTGGCTACTATGGAGGC]

NM_004370.5(COL12Al):c.700 ['TTCTTGACTGATGCCTCCTGGAGCAYTGGGG

2474 1T>C (p.Ile2334Thr) 1303 COL12A1 ACGATAATTTTAACAAAGTT']

NM_019074.3(DLL4):c.583T>C ['CCTGTGCAAGAAGCGCAATGACCACYTCGG

2475 (p.Phel95Leu) 54567 DLL4 CCACTATGTGTGCCAGCCAGA']

NM_019074.3 (DLL4) :c .1168T> ['CCAGGGGGCCAACTATGCTTGTGAAYGTCC

2476 C (p.Cys390Arg) 54567 DLL4 CCCCAACTTCACCGGCTCCAA']

NM_015909.3(NBAS):c.3164T> ['TCAGAGCTTTTGGAAAAACATGGACYCGAG

2477 C (p.Leul055Pro) 51594 NBAS AAACCAATTTCATTTGTTAAA]

NM_000263.3 (NAGLU) :c .1208T ['GCCTCCTTCCAGGGCCAGCCCTTCAYCTGGT

2478 >C (p.Ile403Thr) 4669 NAGLU GCATGCTGCACAACTTTGGG']

NM_203290.2(POLRlC):c.436T ['TCTACAGTTTCGTCTCCAGGTCAGAYGCACT

2479 >C (p.Cysl46Arg) 9533 POLR1C CGGAACCCCCATGCTGCTAA']

NM_018359.3(UFSP2):c.868T> ['CCAGGGCATATATGGCTATCATCATYATATG

2480 C (p.Tyr290His) -1 - CAGGATCGCATAGATGACAA']

NM_000310.3(PPTl):c.2T>C ['CCGCGGTCATGTGACACAGCGAAGAYGGCG

2481 (p.MetlThr) 5538 PPT1 TCGCCCGGCTGCCTGTGGCTC]

NM_021007.2(SCN2A):c.l271T ['CTAATAAATTTGATCTTGGCTGTGGYGGCCA

2482 >C (p.Val424Ala) 6326 SCN2A TGGCCTATGAGGAACAGAAT']

NM_021007.2(SCN2A):c.2306T ['GTTGACCTGGCCATCACCATCTGCAYTGTCT

2483 >C (p.Ile769Thr) 6326 SCN2A TAAATACACTCTTCATGGCT']

NM_021007.2(SCN2A):c.4308+ ['TATGCAGCTGTTGATTCACGAAATGYAAGTC

2484 2T>C 6326 SCN2A TAGTTAGAGGGAAATTGTTT']

NM_021007.2(SCN2A):c.4718T ['TGGATTAATCTGGTGTTTATTGTTCYGTTCA

2485 >C (p.Leul573Pro) 6326 SCN2A CTGGAGAATGTGTGCTGAAA']

NM_001165963.1(SCNlA):c.55 ['CAGCTCATTGCCATGGATTTGCCCAHGGTGA

2486 67T>C (p.Metl856Thr) -1 - GTGGTGACCGGATCCACTGT']

NM_001165963.1(SCNlA):c. lO ['AATCCCAATTATGGCTACACAAGCTYTGATA

2487 94T>C (p.Phe365Ser) 6323 SCN1A CCTTCAGTTGGGCTTTTTTG]

NM_001165963.1(SCNlA):c.66 [TCGGCATTGAGAACATTCAGAGTTCYCCGA

2488 2T>C (p.Leu221Pro) 6323 SCN1A GCATTGAAGACGATTTCAGTC]

NM_000806.5(GABRAl):c.788T ['ATTCAAACATACCTGCCATGCATAAYGACA

2489 >C (p.Met263Thr) 2554 GABRA1 GTGATTCTCTCACAAGTCTCC]

2490 NM_014191.3(SCN8A):c.4889T 6334 SCN8A ['GCCCGTATTGGGCGCATCTTGCGTCYGATCA >C (p.Leul630Pro) AAGGCGCCAAAGGGATTCGT']

NM_005249.4(FOXGl):c.673T> [TTACTACCGCGAGAACAAGCAGGGCYGGCA

2491 C (p.Trp225Arg) 2290 FOXG1 GAACTCCATCCGCCACAATCT']

NM_017882.2(CLN6):c.486+2T ['AAGAATCTCAAGCCGGAGACGCTGGYGAGG

2492 >C 54982 CLN6 CCACCTCCTGCTCCCTGCCTG]

NM_002693.2(POLG):c.l808T> ['AGGGAAGCCATCCCAGGTAAGTGCCRTGAG

2493 C (p.Met603Thr) 5428 POLG TTTAGGTGTGACCCGCATCTG]

NM_002693.2(POLG):c.l283T> ['AGGCAGGTAGGAGACACCCATCTCCRGCAT

2494 C (p.Leu428Pro) 5428 POLG GCCGGCCAGAGTCACTGGGTG]

NM_018129.3 (PNPO) : c.2T>C ['GGGTCACGTGGCCGGCGGCCCCCCAYGACG

2495 (p.MetlThr) 55163 PNPO TGCTGGCTGCGGGGCGTCACG]

NM_007254.3(PNKP):c.1029+2 ['ACCCCCACCCCCGCCCCAGGGCCTCRCCGGA

2496 T>C 11284 PNKP TCAAAGGCTGGGAGCTCGAA']

NM_172107.2(KCNQ2):c.583T> ['CTCCCAGGGCAACGTCTTTGCCACAYCTGCG

2497 C (p.Serl95Pro) 3785 KCNQ2 CTCCGGAGCCTGCGCTTCCT']

NM_000026.2(AD SL) :c .340T>C ['TATTCACCTTGGTGCTACTTCTTGCYATGTTG

2498 (p.Tyrl l4His) 158 ADSL GAGACAATACTGTAGGCGC]

NM_000026.2(AD SL) :c .1339T> ['CCAGTTGGATCATTTACTGGATCCTYCTTCT

2499 C (p.Ser447Pro) 158 ADSL TTCACTGGTCGTGCCTCCCA']

NM_001356.4(DDX3X):c.704T> ['GGGTCTGGAAAAACTGCAGCATTTCYGTTGC

2500 C (p.Leu235Pro) 1654 DDX3X CCATCTTGAGTCAGATTTAT']

NM_001356.4(DDX3X):c.l l75T ['TAAAAATTTTTTTTCTTTCAGATGCYGGCTC

2501 >C (p.Leu392Pro) 1654 DDX3X GTGATTTCTTAGATGAATAT']

NM_001356.4(DDX3X):c.l541T ['GACATTTCAAATGTGAAACATGTTAYCAATT

2502 >C (p.Ile514Thr) 1654 DDX3X TTGACTTGCCAAGTGATATT']

NM_020533.2(MCOLNl):c.317 ['ACCATCGCCTTCCGACACCTCTTCCYGCTGG

2503 T>C (p.Leul06Pro) 57192 MCOLN1 GCTACTCGGACGGAGCGGAT']

NM_020533.2(MCOLNl):c. l340 ['TACTGCTTCTGTGGCTGGATCGTGCYGGGGC

2504 T>C (p.Leu447Pro) 57192 MCOLN1 CCTATCATGTGAAGGTACAT']

NM_000083.2(CLCNl):c. l283T ['CCCCGCGAAGCCATCAGTACTTTGTYTGACA

2505 >C (p.Phe428Ser) 1180 CLCN1 ACAATACATGGGTGAAACAC]

NM_003995.3(NPR2):c.226T>C ['CAGCTCCGAACTGGAAGGCGCCTGCYCTGA

2506 (p.Ser76Pro) 4882 NPR2 GTACCTGGCACCGCTGAGCGC]

NM_004700.3 (KCNQ4) : c.808T> ['GGACGCCAACTCCGACTTCTCCTCCYACGCC

2507 C (p.Tyr270His) 9132 KCNQ4 GACTCGCTCTGGTGGGGGAC]

NM_004700.3 (KCNQ4) : c.823 T> ['CTTCTCCTCCTACGCCGACTCGCTCYGGTGG

2508 C (p.Trp275Arg) 9132 KCNQ4 GGGACGGTGCGTGAGGGTCT']

NM_005097.3(LGIl):c. l24T>C ['GGGGAAGAAACCAGCGAAGCCAAAABGCCC

2509 (p.Cys42Arg) 9211 LGI1 TGCCGTGTGTACTTGTACCAA']

NM_005572.3(LMNA):c.936+2T ['CAGCTCAGCCAGCTCCAGAAGCAGGYGATA

2510 >C 4000 LMNA CCCCACCTCACCCCTCTCTCC]

NM_006009.3 (TUB Al A) : c .1226 ['AAACGTGCCTTTGTTCACTGGTACGYTGGGG

2511 T>C (p.Val409Ala) 7846 TUBA1A AGGGGATGGAGGAAGGTGAG]

2512 NM_001081550.1(THOC2):c. l3 57187 THOC2 ['GACGTGTTCAATATGTTCTGTTACCYTGGTC 13T>C (p.Leu438Pro) CTCACCTTTCTCACGATCCC]

NM_001081550.1(THOC2):c.30 ['ACATCAACAGAAAACTCCAAATTTTYCCAC

2513 34T>C (p.Serl012Pro) 57187 THOC2 ACTTCTTTGCTATGATCGAGT']

NM_001081550.1(THOC2):c.23 ['GATTATATAAAGCGAGTGCCTTCAAYTGATG

2514 99T>C (p.Ile800Thr) 57187 THOC2 TACTCTGTAATGAATTTCAT']

NM_001356.4(DDX3X):c.l520T ['CAGGTAGCAGCAAGAGGACTGGACAYTTCA

2515 >C (p.Ile507Thr) 1654 DDX3X AATGTGAAACATGTTATCAAT']

NM_000158.3(GBEl):c.691+2T ['TGAATAAAAATCACAGTTATTACTTRCCAAG

2516 >C 2632 GBE1 GCCTTTGATTCTTGGTAGTA']

NM_000719.6(C ACNA1 C) :c .34 ['ATGAACATCTTCGTGGGCTTCGTCAYCGTCA

2517 97T>C (p.Ilell66Thr) 775 CACNA1C CCTTTCAGGAGCAGGGGGAG]

NM_001105.4(ACVRl):c.587T> ['TGTACATCAGGAAGTGGCTCTGGTCYTCCTT

2518 C (p.Leul96Pro) 90 ACVR1 TTCTGGTACAAAGAACAGTG]

NM_024531.4(SLC52A2):c.935 ['CCCTACGGGCGTCTGGCCTACCACCYGGCTG

2519 T>C (p.Leu312Pro) 79581 SLC52A2 TGGTGCTGGGCAGTGCTGCC]

NM_033409.3(SLC52A3):c.224 11327 ['AGCTGCCTTTCCGAAGTGCCCATCAYCTTCA

2520 T>C (p.Ile75Thr) 8 SLC52A3 CCCTGCTGGGCGTGGGAACC]

NM_033409.3(SLC52A3):c.49T 11327 ['GGTCTGCGTCTTCGGAATGGGCTCCYGGGTG

2521 >C (p.Trpl7Arg) 8 SLC52A3 ACCATCAATGGGCTCTGGGT']

NM_133433.3(NIPBL):c.6108+2 ['CCATACCTTACCACTAAATGTAGTGYAAGTA

2522 T>C 25836 NIPBL TAGAGCTGTCTTATTCTTGT']

NM_002397.4(MEF2C):c.2T>C ['CGTAATCTGAATCTTTTTTCTCCCCDTAGTCC

2523 (p.MetlThr) 4208 MEF2C CCGTTTTTCTTCTCTCTCT']

NM_000124.3(ERCC6):c.2551T ['AATACTCGCTGACCCTGCTTGTGCCRTATTT

2524 >C (ρ.Τφ851Α¾) 2074 ERCC6 TCAACAAAGACTCAACAACA']

NM_000208.2(INSR):c.l610+2T ['GTTCATGCTGTTCTACAAAGAGGCGYAAGT

2525 >C 3643 INSR AGAAGAGTTAGAGAGACGCTG]

NM_000071.2(CBS):c.325T>C ['CTCCCGCCCGCGTTGAAGAACTCACRCTTGG

2526 (p.Cysl09Arg) 875 CBS CCACTGGGAGGCAGAGATGA']

NM_004550.4(NDUFS2):c.875T ['CATTATGCTCTCCACAGTGGAGTGAYGCTTC

2527 >C (p.Met292Thr) 4720 NDUFS2 GGGGCTCAGGCATCCAGTGG]

NM_003119.3(SPG7):c.2228T> ['AAGGAAGTGATAAACTATGAGGACAYTGAG

2528 C (p.Ile743Thr) 6687 SPG7 GCTCTCATTGGCCCGCCGCCC]

NM_000546.5(TP53):c.584T>C ['CACACGCAAATTTCCTTCCACTCGGRTAAGA

2529 (p.Ilel95Thr) 7157 TP53 TGCTGAGGAGGGGCCAGACC]

NM_018972.2(GDAPl):c.347T> ['AGGTTAATGCCTGATAAAGAAAGCAKGTAT

2530 C (p.Metl l6Thr) 54332 GDAPl TACCCACGGGTACAACATTAC]

NM_000070.2(C APN3 ) : c.566T> ['TGCCTGCCAACGTACAACAATCAACYGGTTT

2531 C (p.Leul89Pro) 825 CAPN3 TCACCAAGTCCAACCACCGC]

NM_000070.2(CAPN3):c.1117T ['TTAATTCCTCCATTTTCCCACCAGAYGGAAG

2532 >C (ρ.Τφ373Α¾) 825 CAPN3 GACTGGAGCTTTGTGGACAA']

NM_181534.3(KRT25):c.950T> 14718 ['AAATTGTTCTTTTCATACCGTGGCTRGGAGA

2533 C (p.Leu317Pro) 3 KRT25 GACTGAAGTTCAATTTCCAG']

2534 NM_001002294.2(FMO3):c.560 2328 FM03 ['CCAGGTGTATTCAATGGAAAGCGTGBCCTG T>C (p.Vall87Ala) GTGGTTGGCCTGGGGAATTCG']

NM_001080522.2(CC2D2A):c.l ['GAAATTCAAGCTGAAATAAGTGAACYGTTA

2535 676T>C (p.Leu559Pro) 57545 CC2D2A GAAGAGCACACGGAGGAGTAC]

NM_001080522.2(CC2D2A):c.3 ['TACCAAGTCATATTTTCTTCACAGAYTGATG

2536 596T>C (p.Ilel l99Thr) 57545 CC2D2A GAACATTTAAAATAGATATT']

NM_025114.3(CEP290):c.2343T ['CCTGTAACAAATGTATTAAATATTCRTTCTG

2537 >C (p.Asn781=) 80184 CEP290 AGAATTAATGATACTGGCAC]

NM_030578.3(B9D2):c.l07T>C ['CGTTTGGCCCTCCCGCACGCCTGACRGGAGC

2538 (p.Leu36Pro) 80776 B9D2 TTCCATGCCGCCCCTGCAGT']

M_004304.4(ALK):c.3520T>C ['ACATCCCTCTCTGCTCTGCAGCAAAKTCAAC

2539 (p.Phel l74Leu) 238 ALK CACCAGAACATTGTTCGCTG]

Table 7 Diseases/disorders containging A to G Changes. The table includes human gene mutations that may be corrected by changing a guanine (G) to adenine (A). The gene name, gene symbol, and Gene ID are indicated.

2A>G CTGGTGGGGAAGAAGTTTTA]

3156 NM_000398.6(CYB5R3):c.719A> 1727 CYB5R3 ['CGCTTCAAGCTCTGGTACACGCTGGRCAG G (p.Asp240Gly) AGCCCCTGAAGGTGAGTGAGGG]

3157 NM_004628.4(XPC):c.413-24A>G 7508 XPC ['ATTATTATTGTTATTACTATTACTGRTTTTT

AAAAATGCTTGTTGATAGAA']

3158 NM_001134363.2(RBM20):c.l909 28299 RBM20 ['TGGCCCAGAAAGGCCGCGGTCTCGTRGTC A>G (p.Ser637Gly) 6 CGGTGAGCCGGTCACTCTCCCC]

3159 NM_000552.3(VWF):c.2384A>G 7450 VWF ['GAGTGTACCAAAACGTGCCAGAACTRTGA (p.Tyr795Cys) CCTGGAGTGCATGAGCATGGGC]

3160 NM_000552.3(VWF):c. l583A>G 7450 VWF ['ACCTGCGGCCTGTGTGGGAATTACARTGG (p.Asn528Ser) C A ACC AGGGC G AC G ACTTC CTT']

3161 NM_144573.3(NEXN):c.l955A>G 91624 NEXN ['ACTTTCCCAGAAGATGGAGGAGAGTRTAT (p.Tyr652Cys) GTGTAAAGCAGTCAACAATAAA']

3162 NM_000267.3(NFl):c.4267A>G 4763 NF1 ['CGAAAGGGGCTTGAAGTTAATGTCARAGG (p.Lysl423Glu) TGAATTATTTTGATAATCTAGC]

3163 NM_000267.3(NFl):c.l642-8A>G 4763 NF1 ['TCTCTTTGTCTTTCTCTTTTTTAAARAATTC

AGGCTCTGCTGGTTCTTCAT']

3164 NM_000267.3 (NF 1 ) :c .1466 A>G 4763 NF1 ['CCTACAGACCTGGAGACAAGAAGCTRTAA (p.Tyr489Cys) GTATCTTCTCTTGTCCATGGTG]

3165 NM_000267.3(NFl):c.5944-5A>G 4763 NF1 ['AAAAACATGTTATTTTCCTTCTTCARCTAG

ATTACAGATCTGCTTGATGTT']

3166 NM_000308.2(CTSA):c.746+3A>G 5476 CTSA ['TACCATGGCCTTCTGGGGAACAGGTRTGG

GATAGGGCAGTTGGGCAATCTC]

3167 NM_000308.2(CTSA):c.200A>G 5476 CTSA ['CTGGCCAAGCAGCCGTCTTTCCGCCRGTAC (p.Gln67Arg) TCCGGCTACCTCAAAGGCTCC]

3168 NM_000308.2(CTSA):c.1238A>G 5476 CTSA ['CTTTAGAAATACCAGATCCTATTATRTAAT (p.Tyr413Cys) GGAGATGTAGACATGGCCTGC]

3169 NM_000308.2(CTSA):c. l411A>G 5476 CTSA ['CTCCCACATCGCCTTTCTCACGATCRAGGT (p.Lys471Glu) AGGGACTGGGCCTGCTGAGAG]

3170 NM_000353.2(TAT):c.236-5A>G 6898 TAT ['TTCCAAACACAGTAGGGTCCCCTTTYTATG

GGAGGAAAACACAAAAGGAGC]

3171 NM_000097.5(CPOX):c.l210A>G 1371 CPOX ['TAATCTGCTGTATGATCGGGGCACARAGTT (p.Lys404Glu) TGGCCTCTTCACTCCAGGATC]

3172 NM_000317.2(PTS):c.l55A>G 5805 PTS ['AACAATCCAAATGGCCATGGGCACARTTA (p.Asn52Ser) TAAAGGTGAGAGAAAAACTGAT']

3173 NM_000317.2(PTS):c.l39A>G 5805 PTS ['ACTGTTTGGGAAATGCAACAATCCARATG (p.Asn47Asp) GCCATGGGCACAATTATAAAGG]

3174 NM_000317.2(PTS):c.347A>G 5805 PTS ['GAAAATGTAGCTGTTTATATCTGGGRCAAC (p.Aspl l6Gly) CTCCAGAAAGTTCTTCCTGTA']

3175 NM_000320.2(QDPR):c.449A>G 5860 QDPR ['CCCCATTTCCCAGGTATGATCGGGTRCGGC (p.Tyrl50Cys) ATGGCCAAGGGTGCTGTTCAC]

3176 NM_173560.3(RFX6):c.224- 22254 RFX6 ['TCTATTTTTCTTTATCATCCCTTCARCTGGC 12A>G 6 AATCAGAAATGCACTTAAAC]

3177 NM_001999.3(FBN2):c.3725- 2201 FBN2 ['TTCATCAATATCTGTGAAAACAGCAYTGC 15A>G AACCACATTGTCAGGTCTGCTT']

3178 NM_001040613.2(TMEM70):c.*7- 54968 TMEM70 ['GATCCTCTCTCTTTTTTTCCCATTTRGGTGT 2A>G GAAATGTTTCTCTTATTCTA']

3179 NM_152416.3(NDUFAF6):c.296A 13768 NDUFAF6 ['AGGGCCTTTAATGTGGAACTGGCTCRGGCT >G (p.Gln99Arg) 2 GGTATTAAGATACCTTAAAAT']

3180 NM_000140.3 (FECH) :c .1137+3 A> 2235 FECH ['ACTAAAACGATTGTAACACTGTAGAYACC G TTAGAGAACAATGGATTTCCAT']

3181 NM_000277.1(PAH):c.lA>G 5053 PAH ['GAGACCTCACTCCCGGGGAGCCAGCDTGT (p.MetlVal) CCACTGCGGTCCTGGAAAACCC]

3182 NM_000277.1(PAH):c.611A>G 5053 PAH ['TCCTTGTATAAAACCCATGCTTGCTRTGAG (p.Tyr204Cys) TACAATCACATTTTTCCACTT']

3183 NM_000277.1(PAH):c.l241A>G 5053 PAH ['ATACCTCGGCCCTTCTCAGTTCGCTRCGAC (p.Tyr414Cys) CCATACACCCAAAGGATTGAG]

3184 NM_000277.1(PAH):c.662A>G 5053 PAH ['CTTGAAAAGTACTGTGGCTTCCATGRAGAT (p.Glu221Gly) AACATTCCCCAGCTGGAAGAC]

3185 NM_000277.1(PAH):c.916A>G 5053 PAH ['TTCTATTTTCCCCCAATTACAGGAARTTGG (p.Ile306Val) CCTTGCCTCTCTGGGTGCACC]

3186 NM_000277.1(PAH):c.l l69A>G 5053 PAH ['TTCCAGCCCCTGTATTACGTGGCAGRGAGT (p.Glu390Gly) TTTAATGATGCCAAGGAGAAA']

3187 NM_000277.1(PAH):c.l065+3A>G 5053 PAH ['TGTCATCCTTTGGTGAATTACAGGTVTGAC

CTTCACAGGAACCAAGGATAG]

3188 NM_000277.1(PAH):c.227A>G 5053 PAH ['AGACCTTCTCGTTTAAAGAAAGATGVGTA (p.Glu76Gly) TGAATTTTTCACCCATTTGGAT']

3189 NM_000130.4(F5):c.l000A>G 2153 F5 ['CATTAAAAACTGCCCAAAGAAAACCRGGA (p.Arg334Gly) ATCTTAAGAAAATAACTCGTGA']

3190 NM_000130.4(F5):c.5189A>G 2153 F5 ['GGCTCTGCCTGTCGGGCTTGGGCCTRCTAC (p.Tyrl730Cys) TCAGCTGTGAACCCAGTAGGT']

3191 NM_000512.4(GALNS):c. l460A> 2588 GALNS ['TTGGTCCCCGCGCAGCCCCAGCTCARCGTG G (p.Asn487Ser) TGCAACTGGGCGGTCATGGTA]

3192 NM_015702.2(MMADHC):c.746A 27249 MMADHC ['ACTCTTTTTGAAACTGATGAACGCTRCCGA >G (p.Tyr249Cys) CATTTAGGATTCTCTGTTGAT']

3193 NM_015141.3(GPDlL):c.370A>G 23171 GPD1L ['TAACTTCTTGGCATCCTTGTAGGGCRTAGA (p.Ilel24Val) CGAGGGCCCCGAGGGGCTGAA']

3194 NM_013319.2(UBIADl):c.305A>G 29914 UBIAD1 ['GTGCACGGGGCCGGTAATTTGGTCARCAC (p.Asnl02Ser) TTACTATGACTTTTCCAAGGGC]

3195 NM_013319.2(UBIADl):c.355A>G 29914 UBIAD1 ['CATTGACCACAAAAAGAGTGATGACRGGA (p.Argl l9Gly) CACTTGTGGACCGAATCTTGGA']

3196 NM_013319.2(UBIADl):c.695A>G 29914 UBIAD1 ['AGCACCGAGGCCATTCTCCATTCCARCAAC (p.Asn232Ser) ACCAGGGACATGGAGTCCGAC]

3197 NM_013319.2(UBIADl):c.335A>G 29914 UBIAD1 ['TACTATGACTTTTCCAAGGGCATTGRCCAC (p.Aspl l2Gly) AAAAAGAGTGATGACAGGACA]

3198 NM_000046.3(ARSB):c.629A>G 411 ARSB ['GTTGCAACAGGATATAAAAATATGTRTTC (p.Tyr210Cys) AACAAACATATTCACCAAAAGG]

3199 NM_006331.7(EMGl):c.257A>G 10436 EMG1 ['CGGGACCCTGGGGAAGCGCGGCCAGRTAT (p.Asp86Gly) CACCCACCAGGTAACTCCAGGG]

3200 NM_000181.3(GUSB):c.l484A>G 2990 GUSB ['CTGCTGCTCTGGTCCTAGGCTCCGTRTGTG (p.Tyr495Cys) GATGTGATCTGTTTGAACAGC]

3201 NM_000067.2(CA2):c.754A>G 760 CA2 ['CTGGCGCCCAGCTCAGCCACTGAAGRACA (p.Asn252Asp) GGCAAATCAAAGCTTCCTTCAA]

3202 NM_000067.2(CA2):c.52A>G 760 CA2 [TCCCCCAGGACCTGAGCACTGGCATVAGG (p.Lysl8Glu) ACTTCCCCATTGCCAAGGGAGA]

3203 M_000404.2(GLBl):c.947A>G 2720 GLB1 ['TTTATAGGTGGGACCAATTTTGCCTRTTGG (p.Tyr316Cys) AATGGTAAGAGCACTTTAATA]

3204 M_000404.2(GLBl):c. l498A>G 2720 GLB1 ['TTTGCAGGGTTTGGTTTCTAACCTGRCTCT (p.Thr500Ala) CAGTTCCAATATCCTCACGGA']

3205 NM_000404.2(GLBl):c. l480- 2720 GLB1 ['GAGAGTCAGGTTAGAAACCAAACCCYGCA 2A>G AAGCAGAAACAGAGCACAGTGA']

3206 M_000404.2(GLBl):c. l772A>G 2720 GLB1 ['ATTAATGGCTTTAACCTTGGCCGCTRTTGG (p.Tyr591Cys) CCAGCCCGGGGCCCTCAGTTG]

3207 NM_203447.3(DOCK8):c.l418A> 81704 D0CK8 ['ACTCTGAGCGTTAGCAGCTTTTTCARGCAG G (p.Lys473Arg) GTATCTCTTCACATTACAGTG]

3208 NM_000275.2(OCA2):c.l465A>G 4948 0CA2 ['TGCCACTGCCATCGGGGACCCTCCARATGT (p.Asn489Asp) CATTATTGTTTCCAACCAAGA']

3209 NM_152778.2(MFSD8):c.362A>G 25647 MFSD8 ['ATTTCCGTGGCAGCCAACTGCCTCTVTGCA (p.Tyrl21Cys) 1 TATCTCCACATCCCAGCTTCT']

3210 NM_139241.3(FGD4):c. l762- 12151 FGD4 ['ACTGTTCATTTTTCTTTTAAATTTARGGTGG 2A>G 2 TTTGTTGGAAATGCTCCGAC]

3211 NM_020223.3(FAM20C):c.l364- 56975 FAM20C ['TGTGACACTTTCTGCCTCTCTCCGCRGGAA 2A>G ACATGGACCGTCACCACTACG]

3212 NM_138387.3(G6PC3):c.346A>G 92579 G6PC3 ['GGCAGGCAGCCCTTCTGGACACTGCRTGA (p.Metl l6Val) TCACAGGAGCAGCCCTCTGGCC]

3213 NM_018122.4(DARS2):c.l33A>G 55157 DARS2 _{TTTTTTTTTTTTTTTTAAAG}^_TTCRGTAGC (p.Ser45Gly) TTTGTTGTCCGGACCAACAC]

3214 NM_000642.2(AGL):c.4260- 178 AGL ['CATCTTTTATTTAACTTAAATTTCARTCATT 12A>G TTGCAGTGATATGGTTTACT']

3215 NM_000642.2(AGL):c.3439A>G 178 AGL ['TCTACTGGGTGAAGGAATTTATGCCRGATA (p.Argl l47Gly) CAATTGTCGGGATGCTGTGTG]

3216 M_145014.2(HYLSl):c.632A>G -1 ['TTAAGCCGAAACCGGGGCAAGACAGRCCG (p.Asp211Gly) GGTAGCCCGGTATTTTGAGTAC]

3217 NM_014362.3(HIBCH):c.365A>G 26275 HIBCH ['GCTCCAGTTTTCTTCAGAGAAGAATRTATG (p.Tyrl22Cys) CTGAATAATGCTGTTGGTATG]

3218 M_014846.3 (KIAAO 196) :c .1411 9897 KIAAO 196 ['TTTTCTTATTTCTGTATTACTAGAARACCTT A>G (p.Asn471Asp) CAAGCTTGGTTCAGAGAGAT']

3219 NM_000505.3(F12):c. l58A>G 2161 F12 ['GAGCCCTGCCACTTCCCCTTCCAGTRCCAC (p.Tyr53Cys) CGGCAGCTGTACCACAAATGT']

3220 NM_001029871.3(RSPO4):c.l94A 34363 RSP04 ['TTCATCCGCCGGGAAGGCATCCGCCRGTA >G (p.Gln65Arg) 7 CGGCAAGTGCCTGCACGACTGT']

3221 NM_017654.3(SAMD9):c.4483A> 54809 SAMD9 ['TAAAAGACTGGAAAGACTTGTTCACRAAG G (p.Lysl495Glu) GAAAAATTGACCAGTGCTTTAA]

3222 NM_152419.2(HGSNAT):c.372- 13805 HGSNAT ['TGTCTTAATTTTACCTAATGTTTGTRGGTTG 2A>G 0 GAATACAGATTTGGAGAATT']

3223 NM_001174089.1(SLC4Al l):c.251 83959 SLC4A11 ['CATGAGCTCCCTGCCCTACATGAAGRTGAT 8A>G (p.Met840Val) CTTTCCCCTCATCATGATCGC]

3224 NM_012073.4(CCT5):c.440A>G 22948 CCT5 ['CAGGCTGCTCGTGTTGCTATTGAACRCCTG (p.Hisl47Arg) GACAAGATCAGCGATAGCGTC]

3225 NM_025114.3(CEP290):c.2991+16 80184 CEP290 ['CACCTGGCCCCAGTTGTAATTGTGARTATC 55A>G TCATACCTATCCCTATTGGCA']

3226 NM_153704.5(TMEM67):c.870- 91147 TMEM67 ['TATTAAAACAGTTGTAACTGTTTATRGGAG 2A>G ACAGAATCTTCCTTGGCTGTT']

3227 NM_153704.5(TMEM67):c.l538A 91147 TMEM67 ['TATCAGGTTTCTTTCTCAGTCACATDTGAA >G (p.Tyr513Cys) ATGGATCATGGAGAAGCACAT']

3228 NM_001041.3(SI):c.350A>G 6476 SI ['GTTGATAATCATGGTTATAACGTTCRAGAC (p.Glnl l7Arg) ATGACAACAACAAGTATTGGT']

3229 NM_015697.7(COQ2):c.890A>G 27235 COQ2 ['TCTGGAGTTATGTGGACACTAATATRTGAT (p.Tyr297Cys) ACTATTTATGCCCATCAGGTA']

3230 NM_015697.7(COQ2):c.683A>G 27235 COQ2 ['GCACTGGGTGTTCTTCTGTGTCTAARTTAC (p.Asn228Ser) TACAGGTATATTAAACGTTTT']

3231 NM_000190.3 (HMB S) : c.1 A>G 3145 HMBS ['CACAGCCTACTTTCCAAGCGGAGCCRTGTC (p.MetlVal) TGGTAACGGCAATGCGGCTGC]

3232 NM_004035.6(ACOXl):c.832A>G 51 ACOX1 ['GAGTAACAAGCTGACTTACGGGACCRTGG (p.Met278Val) TGTTTGTCAGGTCCTTCCTTGT']

3233 NM_004035.6(ACOXl):c.926A>G 51 ACOX1 ['ATCCGATACAGCGCTGTGAGGCACCRGTC (p.Gln309Arg) TGAAATCAAGCCAGGGTAAGGA']

3234 NM_000237.2(LPL):c.548A>G 4023 LPL ['TGCTTTTTTCCCTTTTAAGGCCTCGRTCCAG (p.Aspl83Gly) CTGGACCTAACTTTGAGTAT']

3235 NM_000237.2(LPL):c.953A>G 4023 LPL ['TGCAACAATCTGGGCTATGAGATCARTAA (p.Asn318Ser) AGTCAGAGCCAAAAGAAGCAGC]

3236 NM_001171993.1(HPD):c.362A>G 3242 HPD ['TACATCGGCCAATTCTTGCCTGGATRTGAG (p.Tyrl21Cys) GCCCCAGCGTTCATGGACCCC]

3237 NM_139281.2(WDR36):c.l064A> 13443 WDR36 ['CTTCTTGTCACAAATGGCGCTGACARTGCT G (p.Asn355Ser) 0 CTTAGGGTATTATGATTATTG]

3238 NM_001127255.1(NLRP7):c.2738 -1 ['CTCACAAACCTGGACTTGAGTATCARCCA A>G (p.Asn913Ser) GATAGCTCGTGGATTGTGGATT']

3239 NM_016417.2(GLRX5):c.294A>G 51218 GLRX5 ['TGCTGGACGACCCGGAGCTCCGACARGGT (p.Gln98=) CAGGCCAGTGTGCCGGGCAGGC]

3240 NM_024884.2(L2HGDH):c.293A> 79944 L2HGDH ['ACTGGACATAACAGTGGTGTCATACRTAG G (p.His98Arg) TGGAATTTATTATAAACCTGAG]

3241 NM_000382.2(ALDH3 A2):c.1157 224 ALDH3A2 ['ACATCCAGTGGAGGTGTCACAGGCARTGA A>G (p.Asn386Ser) CGTCATTATGCACTTCACGCTC]

3242 NM_018105.2(THAPl):c.266A>G 55145 THAP1 ['TTTCTTTGTACTGAGCCACATGACARGGTA (p.Lys89Arg) ATATGCATTTTAAAATATTGG]

3243 NM_000785.3(CYP27Bl):c.566A> 1594 CYP27B1 ['GCCCTGGTTCGGGACGTGGCGGGGGRATT G (p.Glul89Gly) TTACAAGTTCGGACTGGAAGGT']

3244 NM_182548.3(LHFPL5):c.380A>G 22266 LHFPL5 ['TTCATCTGCAACACGGCCACAGTCTRTAAG (p.Tyrl27Cys) 2 ATCTGTGCATGGATGCAGCTG]

3245 NM_015040.3 (PIKFYVE) : c.3308 A 20057 PIKFYVE ['TTCAAAGAAATGGAGAACAGGAGGARGA >G (p.Lysl l03Arg) 6 AACAGCTGCTCAGGGATCTCTCT']

3246 NM_138701.3(MPLKIP):c.430A>G 13664 MPLKIP ['GTTGGAAAATTATTTCAAGCCTTCARTGCT (p.Metl44Val) 7 TGAAGATCCTTGGGCTGGCCT']

3247 NM_152783.4(D2HGDH):c. l315A 72829 D2HGDH ['TGCCCTTGTCCCTCCAGGAGATGGTRACCT >G (p.Asn439Asp) 4 GCACCTCAATGTGACGGCGGA]

3248 NM_022912.2(REEPl):c. l83- 65055 REEP1 ['AACTTGTGTTTTCATCTCTCTCTCCRGGTTT 2A>G CCATTCTATTATGAACTAAA']

3249 NM_000060.3(BTD):c.755A>G 686 BTD ['ACATGCTTTGATATATTGTTCTTTGRCCCT (p.Asp252Gly) GCCATCAGAGTCCTCAGAGAC]

3250 NM_022132.4(MCCC2):c.l309A> 64087 MCCC2 ['TGTGGCCTGTGCCCAAGTGCCTAAGDTAA G (p.Ile437Val) CCCTCATCATTGGGGGCTCCTA']

3251 NM_022132.4(MCCC2):c.569A>G 64087 MCCC2 ['GCAGATGTGTTTCCAGATCGAGACCRCTTT (p.Hisl90Arg) GGCCGTACATTCTATAATCAG]

3252 NM_198578.3(LRRK2):c.5096A>G 12089 LRRK2 ['ATCATCCGACTATATGAAATGCCTTRTTTT (p.Tyrl699Cys) 2 CCAATGGGATTTTGGTCAAGA]

3253 NM_198578.3(LRRK2):c.3364A>G 12089 LRRK2 ['TGTGACTAGAAATAAAATATCAGGGRTAT (p.Ilel l22Val) 2 GCTCCCCCTTGAGACTGAAGGA']

3254 NM_000022.2(ADA):c.219-2A>G 100 ADA ['TTCCCAACCCCTTTCTTCCCTTCCCRGGGG

CTGCCGGGAGGCTATCAAAAG]

3255 NM_000022.2(ADA):c.290A>G 100 ADA ['ATGAAGGCCAAAGAGGGCGTGGTGTDTGT (p.Tyr97Cys) GGAGGTGCGGTACAGTCCGCAC]

3256 NM_017780.3(CHD7):c.3082A>G 55636 CHD7 ['TTTAGTAATTGCCCCATTGTCCACARTCCC (p.Ilel028Val) CAACTGGGAAAGGGAATTCCG]

3257 NM_017780.3(CHD7):c.l64A>G 55636 CHD7 ['TTTGCCTCTTTACAGCCATCCCTTCRTCATC (p.His55Arg) CTTCAACTAATCAAAATCAA]

3258 NM_152443.2(RDH12):c.677A>G 14522 RDH12 ['GTCCCAGGCACCGGGGTCACCACCTRCGC (p.Tyr226Cys) 6 AGTGCACCCAGGCGTCGTCCGC]

3259 NM_015335.4(MED13L):c.752A> 23389 MED13L ['TACCCGATGGTGCTAAAAAAGAAAGRAGA G (p.Glu251Gly) ATCGAAAGAGGAAGACGAGTTG]

3260 NM_015335.4(MED13L):c.6068A> 23389 MED13L ['GCTTTTTTTCCCCCCTTCCCTCTAGRTGATA G (p.Asp2023Gly) TGTTTGTTGACCTTCCATTC]

3261 NM_025265.3(TSEN2):c.926A>G 80746 TSEN2 ['TATTTTCAGGCCTTTTTCTTGGTCTRTGCTC (p.Tyr309Cys) TGGGATGTTTAAGTATTTAC]

3262 NM_015384.4(NIPBL):c.7289A>G 25836 NIPBL ['AAAACAGACGTGACTATGCTCTTGTRTATA (p.Tyr2430Cys) GCAGACAATCTAGCCTGTTTT']

3263 NM_207352.3(CYP4V2):c.l091- 28544 CYP4V2 ['GTCATCTTATCTACTTGCTTTCATCRGGGA 2A>G 0 AGTCTGACCGTCCCGCTACAG]

3264 NM_024006.5 (VKORC 1 ) :c .172 A> 79001 VKORC 1 ['CAGCTGTTCGCGCGTCTTCTCCTCCRGGTG G (p.Arg58Gly) TGCACGGGAGTGGGAGGCGTG]

3265 NM_000551.3(VHL):c.491A>G 7428 VHL ['TATACTCTGAAAGAGCGATGCCTCCRGGTT (p.Glnl64Arg) GTCCGGAGCCTAGTCAAGCCT']

3266 NM_000101.3(CYBA):c.281A>G 1535 CYBA ['AATTACTATGTTCGGGCCGTCCTGCRTCTC (p.His94Arg) CTGTGAGTCCCCGTCCCGCAC']

3267 M_014874.3 (MFN2) : c.827 A>G 9927 MFN2 ['TTGTTTGGGCTCCAGGTGCGGCGGCRGCAC (p.Gln276Arg) ATGGAGCGTTGTACCAGCTTC]

3268 NM_015046.5 (SETX) :c .1807 A>G 23064 SETX ['GCAGAAGTCAGATCCACAAAAGTGTYACA (p.Asn603Asp) TGGAGGTGCTTTGAATTTTATG]

3269 NM_005609.2(PYGM):c.lA>G 5837 PYGM ['CAGTCCGGCCCGCCCTCCTGCAGCCVTGTC (p.MetlVal) CCGGCCCCTGTCAGACCAAGA']

3270 NM_033071.3(SYNEl):c.15705- 23345 SYNE1 ['ACTTCACTTCTGTTTTATCCCTGTARTGTTT 12A>G CTGAAGCATGCAGGAGAAAG]

3271 NM_130468.3(CHST14):c.878A>G 11318 CHST14 ['CTGTGCCAGCCTTGTGCCGTGCACTRTGAC (p.Tyr293Cys) 9 TTTGTGGGCTCCTATGAGAGG]

3272 NM_206933.2(USH2A):c. l4020A> 7399 USH2A ['AAAAGTTTTGTATTACGAATTATACRGAAG G (p.Arg4674Gly) ACAAATAGCAACTCAGCCTAG]

3273 NM_000048.3(ASL):c.857A>G 435 ASL ['AGCACGGGAAGCAGCCTGATGCCCCRGAA (p.Gln286Arg) GAAAAACCCCGACAGTTTGGAG]

3274 NM_001875.4(CPSl):c. l010A>G 1373 CPS1 ['CAGGCTTTCATTACTGCTCAGAATCRTGGC (p.His337Arg) TATGCCTTGGACAACACCCTC]

3275 NM_001173464.1(KIF21A):c.2839 55605 KIF21A ['GACCATTTCCAACATGGAGGCAGATRTGA A>G (p.Met947Val) ATAGACTCCTCAAGGTGTGGAA']

3276 NM_000026.2(ADSL):c.736A>G 158 ADSL ['CATCACAGGGCAGACATATACACGARAAG (p.Lys246Glu) TGGATATTGAAGTACTGTCTGT']

3277 NM_024577.3(SH3TC2):c.530- 79628 SH3TC2 ['AGCCATTGCTTTTCTCATTATCCACRGGCC 2A>G ACTTCTTCTGCAGAGCCCTGT']

3278 NM_018249.5(CDK5RAP2):c.4005 55755 CDK5RAP ['AGCATGGGAGATGATTTATCTTTCARTCTC -15A>G 2 AATGGTTAAGGATTGAGGAAG]

3279 NM_000346.3(SOX9):c.517A>G 6662 SOX9 ['GCACAAGAAGGACCACCCGGATTACRAGT (p.Lysl73Glu) ACCAGCCGCGGCGGAGGAAGTC]

3280 M_144596.3(TTC8):c.115-2A>G 12301 TTC8 ['GTTTACTGCCTTCTTAATGCTTTCCRGGAA

6 CCAGATCCTGAATTGCCAGTG]

3281 NM_000243.2(MEFV):c.2080A>G 4210 MEFV ['GAATGGCTACTGGGTGGTGATAATGDTGA (p.Met694Val) AGGAAAATGAGTACCAGGCGTC]

3282 NM_000243.2(MEFV):c.2084A>G 4210 MEFV ['GGCTACTGGGTGGTGATAATGATGADGGA (p.Lys695Arg) AAATGAGTACCAGGCGTCCAGC]

3283 NM_006493.2(CLN5):c.l l21A>G 1203 CLN5 ['GTGCACAAACAGTTCTATTTGTTTTRTAAT (p.Tyr374Cys) TTTGAATATTGGTTTTTACCT']

3284 NM_000483.4(APOC2):c.lA>G -1 ['TCAATGTTCCAGGTCTCTGGACACTRTGGG (p.MetlVal) CACACGACTCCTCCCAGCTCT']

3285 NM_058172.5(ANTXR2):c.l l42A 11842 ANTXR2 ['TGGCCAACTGTGGATGCTTCCTATTDTGGT >G (p.Tyr381Cys) 9 GGTCGAGGGGTTGGAGGAATT']

3286 NM_001128085.1(ASPA):c.692A> -1 ['TATAAAATTATAGAGAAAGTTGATTRCCCC G (p.Tyr231Cys) CGGGATGAAAATGGAGAAATT']

3287 NM_001128085.1(ASPA):c.71A>G -1 - ['ATCTTTGGAGGAACCCATGGGAATGRGCT (p.Glu24Gly) AACCGGAGTATTTCTGGTTAAG]

3288 NM_014365.2(HSPB8):c.421A>G 26353 HSPB8 ['TGGCATTGTTTCTAAGAACTTCACARAGAA (p.Lysl41Glu) AATCCAGTAAGTAACCTGGAG]

3289 NM_000391.3(TPPl):c.857A>G 1200 TPP1 ['CAGTACCTGATGAGTGCTGGTGCCARCATC (p.Asn286Ser) TCCACCTGGGTCTACAGTAGC]

3290 NM_000391.3(TPPl):c.887-10A>G 1200 TPP1 ['TGTCCCTCATGCCGGCCTGGATTTTYTTTTT

TTTTTTTTTTGAGGGATGGG]

3291 NM_182760.3(SUMFl):c.lA>G 28536 SUMF1 ['CGGGTCACATGGCCCGCGGGACAACRTGG (p.MetlVal) 2 CTGCGCCCGCACTAGGGCTGGT']

3292 M_031443.3(CCM2):c.lA>G 83605 CCM2 ['GGCCGCGGGAGCCGCACGCGGCGATRTGG (p.MetlVal) AAGAGGAGGGCAAGAAGGGCAA']

3293 NM_004183.3(BESTl):c.707A>G 7439 BEST1 ['GACTGGATTAGTATCCCACTGGTGTRTACA (p.Tyr236Cys) CAGGTGAGGACTAGGCTGGTG]

3294 NM_004183.3(BESTl):c.680A>G 7439 BEST1 ['ACTCAGTGTGGACACCTGTATGCCTRCGAC (p.Tyr227Cys) TGGATTAGTATCCCACTGGTG]

3295 NM_000158.3(GBEl):c.l634A>G 2632 GBE1 ['TGTAATGCAGGTAATGAATTTGGGCRTCCT (p.His545Arg) GAATGGTTAGACTTCCCAAGA]

3296 NM_000158.3(GBEl):c.l883A>G 2632 GBE1 ['GGTCTTCTTTTCATTTTCAACTTCCRTCCAA (p.His628Arg) GCAAGAGCTACACTGACTAC]

3297 NM_017890.4(VPS13B):c.8978A> 15768 VPS13B ['CTTCTGCCCTGGGCCCTGCTTATCARTGAA G (p.Asn2993Ser) 0 TCCAAATGGGACCTCTGGCTA']

3298 NM_000019.3(ACATl):c.278A>G 38 AC ATI ['GAAGTGAAAGAAGCATACATGGGTARTGT (p.Asn93Ser) TCTACAAGGAGGTGAAGGACAA']

3299 NM_173076.2(ABCA12):c.4139A> 26154 ABCA12 ['CATATTACTTCATTGCTGGGGCCCARTGGA G (p.Asnl380Ser) GCTGGGAAAACTACTACCATG]

3300 NM_030665.3(RAIl):c.4685A>G 10743 RAI1 ['AAGGGGCGTGCCAAGCGACGACGACRGCA (p.Glnl562Arg) GCAGGTGCTGCCCCTGGATCCC]

3301 NM_000271.4(NPCl):c.3467A>G 4864 NPC1 ['AGTCTGAACGCTGTATCCTTGGTCARCCTG (p.Asnl l56Ser) GTGATGGTGAGTCCTCATACA']

3302 NM_000271.4(NPCl):c.3263A>G 4864 NPC1 ['CCCTCCAGTGTGTTTTATGTCTTCTRCGAA (p.Tyrl088Cys) CAGTACCTGACCATCATTGAC]

3303 NM_000543.4(SMPDl):c.l l54A> 6609 SMPD1 ['CTCCGCCTCATCTCTCTCAATATGARTTTTT G (p.Asn385Ser) GTTCCCGTGAGAACTTCTGG']

3304 NM_000226.3(KRT9):c.469A>G 3857 KRT9 ['TCTGACTGCTAATGAGAAGAGCACCRTGC (p.Metl57Val) AGGAACTCAATTCTCGGCTGGC]

3305 NM_000226.3(KRT9):c.482A>G 3857 KRT9 ['GAGAAGAGCACCATGCAGGAACTCADTTC (p.Asnl61Ser) TCGGCTGGCCTCTTACTTGGAT']

3306 NM_176824.2(BBS7):c.968A>G 55212 BBS7 ['ACAGGTCTGACAACAGAGCCCATTCRTAA (p.His323Arg) GGAAAGTGGACCAGGAGAAGAA']

3307 NM_000051.3(ATM):c.3118A>G 472 ATM ['GAGGAAATATATATTCTCTGTAAGARTGG (p.Metl040Val) CCCTAGTAAATTGCCTTAAAAC]

3308 NM_000051.3(ATM):c.7268A>G 472 ATM ['GCTCTCCTGAAAAGAGCCAAAGAGGRAGT (p.Glu2423Gly) AGGTCTCCTTAGGGAACATAAA']

3309 NM_000051.3(ATM):c.8030A>G -1 - ['TATTAGGTGGACCACACAGGAGAATRTGG (p.Tyr2677Cys) AAATCTGGTGACTATACAGTCA]

3310 NM_000487.5(ARSA):c.*96A>G 410 ARSA ['GAGGGGGTTTGTGCCTGATAACGTARTAA

CACCAGTGGAGACTTGCAGATG]

3311 NM_000487.5(ARSA):c.1055 A>G 410 ARSA ['GCCCTGGCTGGGGCCCCACTGCCCARTGTC (p.Asn352Ser) ACCTTGGATGGCTTTGACCTC]

3312 NM_000218.2(KCNQl):c.418A>G 3784 KCNQ1 ['CATCGTCCTGGTCTGCCTCATCTTCRGCGT (p.Serl40Gly) GCTGTCCACCATCGAGCAGTA]

3313 NM_172250.2(MMAA):c.620A>G 16678 MMAA ['GAGTTATCAAGAGATATGAATGCATRCAT (p.Tyr207Cys) 5 CAGGCCATCTCCTACTAGAGGA']

3314 NM_000187.3(HGD):c.l l l2A>G 3081 HGD ['AGTCTACACAGCACAATGACCCCCCRTGG (p.His371Arg) ACCTGATGCTGACTGCTTTGAG]

3315 NM_000187.3(HGD):c.l l02A>G 3081 HGD ['AGGGGGAGGGAGTCTACACAGCACARTGA (p.Met368Val) CCCCCCATGGACCTGATGCTGA']

3316 NM_138477.2(CDANl):c.l796A> 14605 CDAN1 ['CTGAGCTTGAAGATCCAGGAGCTCARTGG G (p.Asn599Ser) 9 TCTTGCCCTGCCCCAGCATGAG]

3317 NM_001079802.1(FKTN):c.l l l2A 2218 FKTN ['GTAAAACTTGATGTTTTTTTCTTCTRTGAA >G (p.Tyr371Cys) GAAACTGATCACATGTGGAAT']

3318 NM_013382.5(POMT2):c.l997A> 29954 POMT2 ['GCTTGAGAAGAGCATGGCTGGGAAGYAGT G (p.Tyr666Cys) GGTGGAAGTAGAGGACCCGGCC]

3319 NM_000529.2(MC2R):c.761A>G 4158 MC2R ['CCAAGTAACCCCTACTGCGCCTGCTRCATG (p.Tyr254Cys) TCTCTCTTCCAGGTGAACGGC]

3320 NM_000383.3(AIRE):c.247A>G 326 AIRE ['CCTGGACTTCTGGAGGGTGCTGTTCRAGGA (p.Lys83Glu) CTACAACCTGGAGCGCTATGG]

3321 NM_020436.3(SALL4):c.2663A>G 57167 SALL4 ['TCGTCTGCTAGCGCTCTTCAGATCCRCGAG (p.His888Arg) CGGACTCACACTGGAGAGAAG]

3322 NM_203288.1(RP9):c.509A>G 6100 RP9 ['CAGTTACTGGAGGATTCTACCTCAGRTGAA (p.Aspl70Gly) GATAGGAGCAGCTCCAGTTCC]

3323 NM_000348.3(SRD5A2):c.692A>G 6716 SRD5A2 ['TTCCTTGGGCTGCGAGCTTTTCACCRCCAT (p.His231Arg) AGGTAAATTTTTCAATAAAAG]

3324 M_006445.3(PRPF8):c.6926A>G 10594 PRPF8 ['CCCAAAGAGTTCTACCACGAGGTGCVCAG (p.His2309Arg) GCCCTCTCACTTCCTCAACTTT']

3325 NM_018319.3(TDPl):c.l478A>G 55775 TDP1 ['TCTGGCCGCAGCAATGCCATGCCACRTATT (p.His493Arg) AAGACATATATGAGGCCTTCT']

3326 M_144773.2(PROKR2):c.629A> 12867 PROKR2 ['AGCCAGGAGAAGATCTTCTGTGGCCRGAT G (p.Gln210Arg) 4 CTGGCCTGTGGATCAGCAGCTC]

3327 NM_001604.5(PAX6):c.l075- 5080 PAX6 ['ACCACAGGTTTGCCTCTCTCCTCACRGCCC 2A>G CCAGTCCCCAGCCAGACCTCC]

3328 NM_000280.4(PAX6):c.l l71A>G 5080 PAX6 ['CAGTCAGCCAATGGGCACCTCGGGCRCCA (p.Thr391Ala) CTTCAACAGGTGAGCCACTGCT']

3329 NM_024426.4(WTl):c.l391A>G 7490 WT1 ['TGTCAGCGAAAGTTCTCCCGGTCCGRCCAC (p.Asp464Gly) CTGAAGACCCACACCAGGACT']

3330 NM_024426.4(WTl):c.l021A>G 7490 WT1 ['TTGCAGCCACAGCACAGGGTACGAGRGCG (p.Ser341Gly) ATAACCACACAACGCCCATCCT']

3331 NM_005957.4(MTHFR):c.971A>G 4524 MTHFR ['CCAGGCCTCCACTTCTACACCCTCARCCGC (p.Asn324Ser) GAGATGGCTACCACAGAGGTG]

3332 NM_001127328.2(ACADM):c.997 34 ACADM ['TAACTCATTCTAGCTAGTTCAACTTYCATT A>G (p.Lys333Glu) GCCATTTCAGCCAGCATAAAT']

3333 NM_001127328.2(ACADM):c.589 34 ACADM ['TATTAATGGTCAGAAGATGTGGATARCCA A>G (p.Thrl97Ala) ACGGAGGAAAAGCTAATTGGTA']

3334 NM_000155.3(GALT):c.940A>G 2592 GALT ['AGGATCAGAGGCTGGGGCCAACTGGRACC (p.Asn314Asp) ATTGGCAGCTGCACGCTCATTA]

3335 NM_000155.3(GALT):c.563A>G 2592 GALT ['TGTTCTAACCCCCACCCCCACTGCCRGGTA (p.Glnl88Arg) AGGGTGTCAGGGGCTCCAGTG]

3336 NM_000250.1(MPO):c.518A>G 4353 MPO ['GTTGCACATCCCGGTGATGGTGCGGYATTT (p.Tyrl73Cys) GTCCTGCTCCGGGCAAGTCAC]

3337 NM_020247.4(ADCK3):c.l541A> 56997 ADCK3 ['TTGGATTTTGGGGCAACGCGGGAATRTGA G (p.Tyr514Cys) CAGATCCTTCACCGACCTCTAC]

3338 NM_000229.1(LCAT):c.463A>G 3931 LCAT ['CACACTGGTGCAGAACCTGGTCAACRATG (p.Asnl55Asp) GCTACGTGCGGGACGAGACTGT']

3339 NM_000403.3 (GALE) : c.101 A>G 2582 GALE ['GGCTACTTGCCTGTGGTCATCGATARCTTC (p.Asn34Ser) CATAATGCCTTCCGTGGTGAG]

3340 NM_001008216.1(GALE):c.308A> 2582 GALE ['GGCGAGTCGGTGCAGAAGCCTCTGGRTTA G (p.Aspl03Gly) TTACAGAGTTAACCTGACCGGG]

3341 NM_000403.3(GALE):c.770A>G 2582 GALE ['AAGGGCCACATTGCAGCCTTAAGGARGCT (p.Lys257Arg) GAAAGAACAGTGTGGCTGCCGG]

3342 NM_000527.4(LDLR):c.2483A>G 3949 LDLR ['AGCATCAACTTTGACAACCCCGTCTRTCAG (p.Tyr828Cys) AAGACCACAGAGGATGAGGTC]

3343 NM_024740.2(ALG9):c.860A>G 79796 ALG9 ['ATTGCACCACTCAACATTGTTTTGTRTAAT (p.Tyr287Cys) GTCTTTACTCCTCATGGACCT']

3344 NM_000375.2(UROS):c.l84A>G 7390 UROS ['TGAAGATTACGGGGGACTCATTTTTRCCAG (p.Thr62Ala) CCCCAGAGCAGTGGAAGCAGC]

3345 NM_000372.4(TYR):c.l25A>G 7299 TYR ['GAATGCTGTCCACCGTGGAGCGGGGRCAG (p.Asp42Gly) GAGTCCCTGTGGCCAGCTTTCA']

3346 NM_000372.4(TYR):c.lA>G 7299 TYR ['AGACCTTGTGAGGACTAGAGGAAGARTGC (p.MetlVal) TCCTGGCTGTTTTGTACTGCCT']

3347 NM_000053.3(ATP7B):c.3809A>G 540 ATP7B ['GTCGCCATGGTGGGGGATGGGGTCADTGA (p.Asnl270Ser) CTCCCCGGCCTTGGCCCAGGCA']

3348 NM_000520.4(HEXA):c.lA>G 3073 HEXA ['CTCCGAGAGGGGAGACCAGCGGGCCVTGA (p.MetlVal) CAAGCTCCAGGCTTTGGTTTTC]

3349 NM_000520.4(HEXA):c.611A>G 3073 HEXA ['AATAAATTGAACGTGTTCCACTGGCRTCTG (p.His204Arg) GTAGATGATCCTTCCTTCCCA]

3350 NM_000356.3 (TCOF 1 ) :c .149 A>G 6949 TCOF1 ['CAGCCCGTAACCCTTCTGGACATCTRTACA (p.Tyr50Cys) CACTGGCAACAGTAAGTGGTG]

3351 M_000144.4(FXN):c.385-2A>G 2395 FXN ['ATGCTTTTTTTCCACCTAATCCCCTRGAGT

GGTGTCTTAACTGTCAAACTG]

3352 NM_016335.4(PRODH) :c.1562 A> 5625 PRODH ['GCCTAGCAGCTGTCCAAAGTACACCYGGT G (p.Gln521Arg) GGTCAGCAGGATGCAGGCCCAG]

3353 M_015474.3(SAMHDl):c.760A> 25939 SAMHD1 ['TAATTCTAATGGAATTAAGCCTGTCRTGGA G (p.Met254Val) ACAATATGGTCTCATCCCTGA]

3354 NM_012464.4(TLLl):c.l885A>G 7092 TLL1 [ACTTCTTACCAAACTTAACGGCACCRTAAC (p.Ile629Val) CACCCCTGGCTGGCCCAAGGA]

3355 NM_000112.3(SLC26A2):c.l273A 1836 SLC26A2 ['GGAAATGTATGCCATTGGCTTTTGTRATAT >G (p.Asn425Asp) CATCCCTTCCTTCTTCCACTG]

3356 NM_138691.2(TMCl):c.l960A>G 11753 TMC1 ['CCTGTCCACAATGCCTGTCTTGTACRTGAT (p.Met654Val) 1 CGTGTCCCTCCCACCATCTTT']

3357 NM_000173.6(GPlBA):c.763A>G 2811 GP1BA ['GAAGCAAGGTGTGGACGTCAAGGCCRTGA (p.Met255Val) CCTCTAATGTGGCCAGTGTGCA']

3358 NM_024996.5(GFMl):c.521A>G 85476 GFM1 ['AACGTTCCGTTTCTAACTTTTATTARCAAA (p.Asnl74Ser) TTGGACCGAATGGGCTCCAAC]

3359 NM_024301.4(FKRP):c.926A>G 79147 FKRP ['GTGGGCGACACGCCCGCCTACCTCTRCGA (p.Tyr309Cys) GGAGCGCTGGACGCCCCCCTGC]

3360 NM_024301.4(FKRP) :c.1387 A>G 79147 FKRP ['TGCCGGCTTCGTGGCGCAGGCGCCTRACA (p.Asn463Asp) ACTACCGCCGCTTCCTGGAGCT']

3361 NM_021020.3(LZTSl):c.355A>G 11178 LZTS1 ['TCCTTTTCCTCTACAGGGCTCCGAGRAGGG (p.Lysl l9Glu) TGCAGTGAGGCCCACAGCCTT']

3362 NM_001005741.2(GBA):c.l226A> 2629 GBA ['CCAGCCGACCACATGGTACAGGAGGBTCT G (p.Asn409Ser) AGGGTAAGGACAAAGGCAAAGA']

3363 NM_000157.3(GBA):c.680A>G 2629 GBA ['ACATCACCCACTTGGCTCAAGACCARTGG (p.Asn227Ser) AGCGGTGAATGGGAAGGGGTCA']

3364 NM_001005741.2(GBA):c.l049A> 2629 GBA ['AAATATGTTCATGGCATTGCTGTACRTTGG G (p.His350Arg) TACCTGGACTTTCTGGCTCCA']

3365 NM_014239.3(EIF2B2):c.638A>G 8892 EIF2B2 ['GTGAATTTGTCCAAAGCAGGTATTGRGAC (p.Glu213Gly) AACTGTCATGACTGATGCTGCC]

3366 NM_015915.4(ATLl):c.773A>G 51062 ATL1 ['CTACAGAACGTCAGAAAACACATCCRTTC (p.His258Arg) CTGTTTCACCAACATTTCCTGT']

3367 NM_015915.4(ATLl):c.l222A>G 51062 ATL1 ['GAAGCTATTCCGAGGGGTGAAGAAGRTGG (p.Met408Val) GTGGGGAAGAATTTAGCCGGCG]

3368 NM_022051.2(EGLNl):c. l l21A>G 54583 EGLN1 ['TTCTGGTCTGACCGTCGCAACCCTCRTGAA (p.His374Arg) GTACAACCAGCATATGCTACA']

3369 NM_015629.3(PRPF31):c.527+3A> 26121 PRPF31 ['GTCACCGCCTCCACCACCCAGGGGTRTGTC G CGCTTCGAGGGAGGCGCCGGG]

3370 NM_001243133.1(NLRP3):c.l880 11454 NLRP3 ['CTGCAGATCCAGCCCAGCCAGCTGGRATT A>G (p.Glu627Gly) 8 GTTCTACTGTTTGTACGAGATG]

3371 NM_020919.3(ALS2):c.2980- 57679 ALS2 ['CTTATTGACGTTACTTTTTGCTCCTRGACA 2A>G AAGTGGCTACGAGCTATAAGC]

3372 NM_175073.2(APTX):c.602A>G 54840 APTX ['GATAAATACCCAAAGGCCCGTTACCRTTG (p.His201Arg) GCTGGTCTTACCGTGGACCTCC]

3373 NM_001002010.2(NT5C3A):c.686 51251 NT5C3A ['CATCCCAATGTCAAAGTTGTGTCCARTTTT A>G (p.Asn229Ser) ATGGATTTTGATGAAACTGTA']

3374 NM_020451.2(SEPNl):c. lA>G 57190 SEPN1 ['CCGGCAGCCGCCGCCAGCCGCAGCCRTGG (p.MetlVal) GCCGGGCCCGGCCGGGCCAACG]

3375 NM_032667.6(BSCL2):c.263A>G -1 - ['TCACTCTGCTCCTTCCCTGTTGCCARTGTCT (p.Asn88Ser) CGCTGACTAAGGGTGGACGT']

3376 NM_153638.2(PANK2):c.700A>G 80025 PANK2 ['GGTATATTTTGAACCCAAAGACATCRCTGC (p.Thr234Ala) TGAAGAAGAAGAGGAAGAAGT']

3377 NM_025243.3(SLC19A3):c.l264A 80704 SLC19A3 ['TGCCTTGGTGATTCAGACCATCATGRCTGT >G (p.Thr422Ala) GATTGTAGTAGATCAGAGAGG]

3378 NM_025243.3(SLC19A3):c.l30A> 80704 SLC19A3 ['TATCCCATATTTATCTGGACCAGATRAAAA G (p.Lys44Glu) CCTGACCAGTGCAGAGGTAAG]

3379 NM_031885.3(BBS2):c.209A>G 583 BBS2 ['CAGACAGCTGACTGCCTGGTTAATGYTGA (p.Asn70Ser) GAAGAGAAACATCAGATTCCAG]

3380 NM_032383.4(HPS3):c.2482-2A>G -1 ['TTTATGAGAAATTCTTTTATGTTTTRGATA

AATGCCTGTAGTCATTATGGC]

3381 NM_021830.4(C10orf2):c.955A>G 56652 C10orf2 ['TGACCTTCGGTCCTGGGAAGCCGCCVAGTT (p.Lys319Glu) GTTTGCACGAAAACTGAACCC]

3382 NM_021830.4(C10orf2):c.l523A> 56652 C10orf2 ['ACAATGCAACATGCAGTCTACGTCTRTGAC G (p.Tyr508Cys) ATTTGTCATGTGATCATCGAC]

3383 NM_006492.2(ALX3):c.608A>G 257 ALX3 ['ACCTGCCCCCAGGTCTGGTTCCAGARCCGC (p.Asn203Ser) AGAGCCAAGTGGCGGAAGCGC]

3384 NM_174916.2(UBRl):c.407A>G 19713 UBR1 ['TTCCAGGACAGTGTTCATAAAAATCRTCGT (p.Hisl36Arg) 1 TACAAGGTAAGAAAATATAAC]

3385 NM_015166.3(MLCl):c.422A>G 23209 MLC1 ['CTAGTCCTGAACCCATCAGCAATAARCGT (p.Asnl41Ser) GAGTTCACACGAGCTTCGCGCA']

3386 NM_013391.3(DMGDH):c.326A> 29958 DMGDH ['CCTGGAATAAACTTGAAGAAAATACRTTA G (p.Hisl09Arg) TGATAGCATCAAACTTTATGAG]

3387 NM_014795.3(ZEB2):c.3356A>G 9839 ZEB2 ['GCTTACTTGCAGAGCATTACCCCTCRGGGG (p.Glnl ll9Arg) TACTCTGACTCGGAGGAGAGG]

3388 M_000441.1 (SLC26 A4) :c.1151 A 5172 SLC26A4 ['GTTGTCATCCAGTCTCTTCCTTAGGRATTC >G (p.Glu384Gly) ATTGCCTTTGGGATCAGCAAC]

3389 M_000441.1 (SLC26 A4) :c.1105 A 5172 SLC26A4 ['TTATGCTATTGCAGTGTCAGTAGGARAAGT >G (p.Lys369Glu) ATATGCCACCAAGTATGATTA']

3390 M_000441.1 (SLC26 A4) :c.2168A 5172 SLC26A4 ['AAGGACACATTCTTTTTGACGGTCCRTGAT >G (p.His723Arg) GCTATACTCTATCTACAGAAC]

3391 M_000441.1 (SLC26 A4) :c.919- 5172 SLC26A4 ['TTTTTAACATCTTTTGTTTTATTTCRGACGA 2A>G TAATTGCTACTGCCATTTCA']

3392 NM_000197.1(HSD17B3):c.703A> 3293 HSD17B3 ['GACCCCATATGCTGTCTCGACTGCARTGAC G (p.Met235Val) AAAGTATCTAAATACAAATGT']

3393 NM_000197.1(HSD17B3):c.389A> 3293 HSD17B3 ['TTGTTTTGCTTCTTTCTGCCAGTCARCAATG G (p.Asnl30Ser) TCGGAATGCTTCCAAACCTT']

3394 NM_022458.3(LMBRl):c.423+525 64327 LMBR1 ['GTTTTGATCTTAGTGTTTATTACAGRAAAT 2A>G GAAGCCATATCTCACTAACTA']

3395 NM_020366.3(RPGRIPl):c.3341A 57096 RPGRIP1 ['CTAAATAAACATTTTCCTTATCAGGRTTCA >G (p.Aspl l l4Gly) GAGAAGATGTGCATTGAAATT']

3396 NM_021625.4(TRPV4):c.998A>G 59341 TRPV4 ['CTGCATGCGCTGGTGGCCATTGCTGRCAAC (p.Asp333Gly) ACCCGTGAGAACACCAAGTTT']

3397 NM_004897.4(MINPPl):c.809A>G 9562 MINPP1 ['TTAAAAAAAGTTGCAGCTACTTTGCRAGTG (p.Gln270Arg) CCAGTAAATGATTTAAATGCA']

3398 NM_020638.2(FGF23):c.211A>G 8074 FGF23 ['TGGCGCACCCCATCAGACCATCTACRGTG (p.Ser71Gly) AGTAGGGCTTCAGGCTGGGAAG]

3399 NM_015071.4(ARHGAP26):c.l250 23092 ARHGAP2 ['GGGCTGTATCGAATTGTGGGTGTCAVCTCC A>G (p.Asn417Ser) 6 AGAGTGCAGAAGTTGCTGAGT']

3400 NM_021615.4(CHST6):c.521A>G 4166 CHST6 ['CGCTCCTACAGCCACGTGGTGCTCARGGA (p.Lysl74Arg) GGTGCGCTTCTTCAACCTGCAG]

3401 NM_021615.4(CHST6):c.329A>G 4166 CHST6 ['TGCGACATGGACGTGTTTGATGCCTRTCTG (p.Tyrl lOCys) CCTTGGCGCCGCAACCTGTCC]

3402 NM_015560.2(OPAl):c.l745A>G 4976 OPA1 ['CTTGAAACTGAATGGAAGAATAACTRTCC (p.Tyr582Cys) TCGCCTGCGGGAACTTGACCGG]

3403 NM_000368.4(TSCl):c.1760 A>G 7248 TSC1 ['AGTATCTTCACTCCCAGTCCTTGTARAATT (p.Lys587Arg) CCACCTCCGACGAGAGTGGGC]

3404 NM_020661.2(AICDA):c.415A>G 57379 AICDA ['CCGCGCCGGGGTGCAAATAGCCATCRTGA (p.Metl39Val) CCTTCAAAGGTGCGAAAGGGCC]

3405 NM_020533.2(MCOLNl):c.406- 57192 MCOLN1 ['ACAGGCCCTCCCCTTCTCTGCCCACRGTAC 2A>G CTGGCGTTGCCTGACGTGTCA']

3406 NM_021102.3(SPINT2):c.488A>G 10653 SPINT2 ['AGGAACTCCTGCAATAACTTCATCTRTGGA (p.Tyrl63Cys) GGCTGCCGGGGCAATAAGAAC]

3407 NM_006610.3 (M ASP2) :c .359 A>G 10747 MASP2 ['GGGAGGGCTGGGGTTTCTCAGGGTCRGGG (p.Aspl20Gly) GGTCCCCAAGGAGTAGCCAGGG, 3410 AGGGGCCAGGCTTGGCCAGGAGGGASATC

AGGCCTGGGTCTTGCCTTCACT',

'GGGCAGGAGAGCACAGACACGGAGCRGGC

CCCTGGCAAGGACACTTTCTAC,

AGCCTGGACATTACCTTCCGCTCCGRCTAC

TCCAACGAGAAGCYGTTCACG]

3411 NM_018965.3(TREM2):c.401A>G 54209 TREM2 ['GCTCTGCCTCCCATAGACCCCCTGGRTCAC (p.Aspl34Gly) CGGGATGCTGGAGATCTCTGG]

3412 NM_007375.3(TARDBP):c.l009A 23435 TARDBP ['AGCACTACAGAGCAGTTGGGGTATGRTGG >G (p.Met337Val) GCATGTTAGCCAGCCAGCAGAA']

3413 NM_007375.3(TARDBP):c.506A> 23435 TARDBP ['GTAATGTCACAGCGACATATGATAGRTGG G (p.Aspl69Gly) ACGATGGTGTGACTGCAAACTT']

3414 NM_007375.3(TARDBP):c.l028A 23435 TARDBP ['GGTATGATGGGCATGTTAGCCAGCCRGCA >G (p.Gln343Arg) GAACCAGTCAGGCCCATCGGGT']

3415 NM_007375.3(TARDBP):c.787A> 23435 TARDBP ['CGTTCATATATCCAATGCCGAACCTRAGCA G (p.Lys263Glu) CAATAGCAATAGACAGTTAGA']

3416 NM_015247.2(CYLD):c.2240 A>G 1540 CYLD ['ATCAACAGTAACCTGAAATTTGCAGRGGT (p.Glu747Gly) TAGTGATACTCACCTGTGGTAT']

3417 NM_001128425.1(MUTYH):c.536 4595 MUTYH ['AATCAACTCTGGGCTGGCCTGGGCTRCTAT A>G (p.Tyrl79Cys) TCTCGTGGCCGGCGGCTGCAG]

3418 NM_001128425.1(MUTYH):c. l241 4595 MUTYH ['TCCGTGACCTGGGAGCCCTCAGAGCRGCTT A>G (p.Gln414Arg) CAGCGCAAGGCCCTGCTGCAG]

3419 NM_170784.2(MKKS):c. llOA>G 8195 MKKS ['TTGAAAAGAATTGTAACATCATGCTRTGGC (p.Tyr37Cys) CCCTCAGGTAGGCTGAAGCAG]

3420 NM_170784.2(MKKS):c.169A>G 8195 MKKS ['TGGCTTTGGAGGTTACGTGTGTACARCCTC (p.Thr57Ala) ACAGTCCTCAGCTCTGCTCAG]

3421 NM_004795.3(KL):c.578A>G 9365 KL ['GTGCAGCCCGTGGTCACCCTGTACCRCTGG (p.Hisl93Arg) GACCTGCCCCAGCGCCTGCAG]

3422 NM_014625.3(NPHS2):c.479A>G 7827 NPHS2 ['CTTTTCTTTTTTTTGCCCTGCCTGGRTACCT (p.Aspl60Gly) ACCACAAGGTTGACCTTCGT']

3423 NM_015713.4(RRM2B):c.322- 50484 RRM2B ['CACCTCCTGACTAAAGCGCTCCACCBAAG 2A>G AAGATAAGGAAAATAGATATAT']

3424 NM_006343.2(MERTK):c.l605- 10461 MERTK ['GAAGTATCTTTGTTTTCATTCACCCRGGAA 2A>G TGCATTCACAGAGGAGGATTC]

3425 NM_014585.5(SLC40Al):c.470A> 30061 SLC40A1 ['GCTACTGCAATCACAATCCAAAGGGRTTG G (p.Aspl57Gly) GATTGTTGTTGTTGCAGGAGAA']

3426 NM_004924.4(ACTN4):c.763A>G 81 ACTN4 ['CGTGAACACGGCCCGGCCCGACGAGRAGG (p.Lys255Glu) CCATAATGACCTATGTGTCCAG]

3427 NM_012193.3 (FZD4) :c .1024 A>G -1 ['CAAATGGGGTCATGAAGCCATTGAARTGC (p.Met342Val) ACAGCTCTTATTTCCACATTGC]

3428 NM_012193.3(FZD4):c.766A>G -1 ['GTTTTCCTACCCTGAGCGCCCCATCRTATT (p.Ile256Val) TCTCAGTATGTGCTATAATAT']

NM_004239.3(TRIPll):c.202- 9321 TRIP 11

2A>G

3429 NM_004239.3(TRIPll):c.2102A>G 9321 TRIP 11 ['AGTGTTTTTTTCCAGAGAAAGCTGAYTGTT (p.Asn701Ser) ACCAGCAAGACATTCTTCTAA']

3430 NM_012434.4(SLC17A5):c.548A> 26503 SLC17A5 ['CAGGGTGTTACATTTCCAGCCATGCRTGCC G (p.Hisl83Arg) ATGTGGTCTTCTTGGGCTCCC]

3431 NM_001099274.1(TINF2):c.838A> 26277 TINF2 ['ATGGGCCTCCACTAGGGGAGGCCATDAGG G (p.Lys280Glu) AGCGCCCCACAGTCATGCTGTT']

3432 NM_012415.3(RAD54B):c.l778A> 25788 RAD54B ['AGAGTTGAACAAAAGGCAGGGGTGAYTGC G (p.Asn593Ser) ACAGTTTTTTAAGAGCTCCTAT']

3433 NM_014946.3(SPAST):c.l688- 6683 SPAST ['TAAGTGCCTGACTTTTATGTTTTACRGAAC 2A>G TAAAACCAGAACAGGTGAAGA']

3434 M_014946.3(SPAST):c.l322A>G 6683 SPAST ['AGTCTTATACTTGTATTTCCTCTAGRTGAA (p.Asp441Gly) GTTGATAGCCTTTTGTGTGAA']

3435 M_014946.3(SPAST):c.l245+4A 6683 SPAST ['TGCAAGTTTAACTTCAAAATACGTGRGTGC >G TCTGTTTCCAATATTGTCGTA]

3436 M_014946.3(SPAST):c.l l57A>G 6683 SPAST ['CTGTTACTCTTTGGTCCACCTGGGARTGGG (p.Asn386Ser) AAGACAATGCTGGTAAGGGTT']

3437 M_014946.3 (SP AST) :c .1216 A>G 6683 SPAST ['AGAATCGAATGCAACCTTCTTTAATRTAAG (p.Ile406Val) TGCTGCAAGTTTAACTTCAAA']

3438 NM_182643.2(DLCl):c.2875A>G 10395 DLC1 ['ACACCTGGATGTGGACAACGACCGARCCA (p.Thr959Ala) CACCCAGCGACCTGGACAGCAC]

3439 M_194456.1(KRITl):c.410A>G 889 KRIT1 ['TGCCCAATTTTTTACTGCTTACAAGRTATT (p.Aspl37Gly) ATGCGAGTCTGTAGTGAATCC]

3440 NM_005094.3(SLC27A4):c.899A> 10999 SLC27A4 ['CCAGGAAACATCGTGGGAATCGGCCRGTG G (p.Gln300Arg) CCTGCTGCATGGCATGACGGTG]

3441 NM_004211.3(SLC6A5):c.l472A> 9152 SLC6A5 ['GGAGGCCTGATCACTCTCTCTTCTTRCAAC G (p.Tyr491Cys) AAATTCCACAACAACTGCTAC]

3442 NM_004211.3 (SLC6 A5) :c.1526A> 9152 SLC6A5 ['GACACTCTAATTGTCACCTGCACCARCAGT G (p.Asn509Ser) GCCACAAGCATCTTTGCCGGC]

3443 NM_014270.4(SLC7A9):c.695A>G 11136 SLC7A9 ['GCGTTTTACAATGGACTCTGGGCCTRTGAT (p.Tyr232Cys) GGATGGTGAGGTGTCCTGAGA']

3444 NM_139025.4(ADAMTS13):c.l58 11093 ADAMTS1 ['GAGCCTGTGTGTGTCGGGCAGCTGCRGGG 2A>G (p.Arg528Gly) 3 TAGGCGTGTGTGGACATTGGCG]

3445 NM_002894.2(RBBP8):c.l009A>G 5932 RBBP8 ['TGTATTTGGAGCTACCTCTAGTATCRAAAG (p.Lys337Glu) TGGTTTAGATTTGAATACAAG]

3446 NM_005682.6(ADGRGl):c.263A> 9289 ADGRG1 ['TCCTTCCCTGACCCCAGGGGCCTCTRCCAC G (p.Tyr88Cys) TTCTGCCTCTACTGGAACCGA']

3447 NM_006502.2(POLH):c.1603 A>G 5429 POLH ['AGGAACTGAGCCCTTCTTTAAGCAGRAAA (p.Lys535Glu) GTCTGCTTCTAAAGCAGAAACA']

3448 NM_000334.4(SCN4A):c.4774A>G 6329 SCN4A ['CATCTCCTTCCTCATCGTGGTCAACRTGTA (p.Metl592Val) CATCGCCATCATCCTGGAGAA']

3449 NM_000334.4(SCN4A):c.3478A>G 6329 SCN4A ['CGCCCTCCTAGGCGCCATCCCCTCCRTCAT (p.Ilel l60Val) GAATGTGCTGCTTGTCTGCCT']

3450 NM_000334.4(SCN4A):c.421A>G 6329 SCN4A ['GTTCAGCATGTTCATCATGATCACCRTCTT (p.Ilel41Val) GACCAACTGCGTATTCATGAC]

3451 NM_003907.2(EIF2B5):c.271A>G 8893 EIF2B5 ['CCTGACTGCCACAGGTGTACAGGAARCAT (p.Thr91Ala) TTGTCTTTTGTTGCTGGAAAGC]

3452 NM_001128227.2(GNE):c.604A>G 10020 GNE ['CAGTGCAGAGCAGCACCTGATATCCRTGT (p.Met202Val) GTGAGGACCATGATCGCATCCT']

3453 NM_001029.3(RPS26):c.lA>G 6231 RPS26 ['CCTCTCTCCGGTCCGTGCCTCCAAGDTGGT (p.MetlVal) GAGTCTTCTTGCGTGGTGAGG]

3454 NM_012082.3(ZFPM2):c.l969A>G -1 ['TCAAACTAAGAAGCTCTCCACCTCCRGTAA (p.Ser657Gly) CAATGATGACAAAATTAATGG]

3455 NM_012082.3(ZFPM2):c.89A>G 23414 ZFPM2 ['GATGAGGAAGAAGAATGTCCATCAGRGGA (p.Glu30Gly) AACAGACATCATCTCCAAAGGA']

3456 NM_012082.3(ZFPM2):c.2527A>G -1 ['AAAGTGTTTATCTCAGTCTGAGCGGRCGAC (p.Thr843Ala) CACGTCTCCCAAAAGGCTGCT']

3457 NM_194248.2(OTOF):c.766-2A>G 9381 OTOF ['TCTGGCTCCCCCTTCTCCTGCCTGCRGGTC

AGCATCACGGTGATCGAGGCC]

3458 NM_003705.4(SLC25A12):c.l769 8604 SLC25A12 ['GCTCGAGTGTTTCGATCCTCTCCCCRGTTT A>G (p.Gln590Arg) GGTGTTACCTTGGTCACTTAT']

3459 NM_004621.5(TRPC6):c.428A>G 7225 TRPC6 ['AATGCCCTACAGTTGGCAGTGGCCARTGA (p.Asnl43Ser) GCATCTGGAAATTACAGAACTT']

3460 NM_152384.2(BBS5):c.522+3A>G 12988 BBS5 ['TTTGGAATTTATCCAGTGATCAGGTRTTGT

0 GCAAAGAGCTAGTGAACCTTT']

3461 NM_152384.2(BBS5):c.547A>G 12988 BBS5 ['GGGCAATTTAGGAACCTTTTTTATTRCCAA (p.Thrl83Ala) 0 TGTGAGAATTGTGTGGCATGC]

3462 NM_001257342.1(BCSlL):c.232A 617 BCS1L ['CCACAGTACCCGTACTCAGCACCTCRGTGT >G (p.Ser78Gly) CGAGACTTCGTACCTTCAGCA]

3463 NM_004328.4(BCSlL):c. l48A>G 617 BCS1L ['GGCATTCCGGCGCCATTACATGATCRCACT (p.Thr50Ala) GGAAGTCCCTGCTCGAGACAG]

3464 NM_003839.3(TNFRSFl lA):c.508 8792 TNFRSF11 ['TGCCTTTTCCTCCACGGACAAATGCRGACC A>G (p.Argl70Gly) A CTGGACCAAGTAAGTAACAAC]

3465 NM_030761.4(WNT4):c.647A>G 54361 WNT4 ['TGCCACGGGGTGTCAGGCTCCTGTGRGGT (p.Glu216Gly) AAAGACGTGCTGGCGAGCCGTG]

3466 NM_022817.2(PER2):c. l984A>G 8864 PER2 ['GCTGGCACTGCCGGGCAAGGCAGAGRGTG (p.Ser662Gly) TGGCGTCGCTCACCAGCCAGTG]

3467 NM_002977.3(SCN9A):c. l964A>G -1 ['TAGGGCACGACCAATCAAATACACARGAA (p.Lys655Arg) AAGGCGTTGTAGTTCCTATCTC]

3468 NM_002977.3(SCN9A):c. l84A>G 6335 SCN9A ['GGAAGCTGGCAAACAGCTGCCCTTCRTCT (p.Ile62Val) ATGGGGACATTCCTCCCGGCAT']

3469 NM_002977.3(SCN9A):c.29A>G 6335 SCN9A ['GCAATGTTGCCTCCCCCAGGACCTCRGAGC (p.GlnlOArg) TTTGTCCATTTCACAAAACAG]

3470 NM_001457.3(FLNB):c.604A>G 2317 FLNB ['GCCTGTGGATAATGCACGAGAAGCCRTGC (p.Met202Val) AGCAGGCAGATGACTGGCTGGG]

3471 NM_003060.3(SLC22A5):c.632A> 6584 SLC22A5 ['GTAGGCATGGGCCAGATCTCCAACTRTGT G (p.Tyr211Cys) GGCAGCATTTGTCCTGGGTATG]

3472 NM_000369.2(TSHR):c.l856A>G 7253 TSHR ['CCGCAGTACAACCCAGGGGACAAAGRTAC (p.Asp619Gly) CAAAATTGCCAAGAGGATGGCT']

3473 NM_000369.2(TSHR):c.548A>G 7253 TSHR ['TCTCTTCTCTCTGTTGGTTGTAGGARGCTG (p.Lysl83Arg) TACAACAATGGCTTTACTTCA']

3474 NM_001430.4(EPASl):c. l603A>G 2034 EPAS1 ['GGAGACACTGGCACCCTATATCCCCRTGG (p.Met535Val) ACGGGGAAGACTTCCAGCTAAG]

3475 NM_024009.2(GJB3):c.421A>G 2707 GJB3 ['GTTCAGCCTCATCTTCAAGCTCATCRTTGA (p.Ilel41Val) GTTCCTCTTCCTCTACCTGCT']

3476 NM_024009.2(GJB3):c.497A>G 2707 GJB3 ['ATGCCGCGCCTGGTGCAGTGTGCCADCGT (p.Asnl66Ser) GGCCCCCTGCCCCAACATCGTG]

3477 NM_001080463.1(DYNC2Hl):c.l l 79659 DYNC2H1 ['TGTTTTTTTGCTTTTGTAGGTTGCCRTGGGT 284A>G (p.Met3762Val) CAAGGTCAAGCTGATTTAGC]

3478 NM_001080463.1(DYNC2Hl):c.90 79659 DYNC2H1 ['CGCATGCCACCTGATGTAATTAGAGRTATT 44A>G (p.Asp3015Gly) CTTGAAGGAGTTTTAAGGTTG]

3479 NM_001080463.1(DYNC2Hl):c.46 79659 DYNC2H1 ['GTTGACCCATCTCTGTTCCCTTCACRGGTA 10A>G (p.Glnl537Arg) AGGGGGCTTACGTGTAGAAGC]

3480 NM_001080463.1(DYNC2Hl):c.59 79659 DYNC2H1 ['TGGTCCAAGTGGTGCTGGAAAATCARCGC 59A>G (p.Thrl987Ala) TTTGGAGAATGTTAAGGGCTGC]

3481 NM_007035.3 (KERA) :c.740 A>G 11081 KERA ['GTGGCCTTTTTGAGACTAAATCACARCAAA (p.Asn247Ser) CTGTCAGATGAGGGTCTCCCA]

3482 NM_003722.4(TP63):c.697A>G 8626 TP63 ['TATCCGCGCCATGCCTGTCTACAAARAAGC (p.Lys233Glu) TGAGCACGTCACGGAGGTGGT']

3483 NM_003722.4(TP63):c.1052A>G 8626 TP63 ['CGGATCTGTGCTTGCCCAGGAAGAGRCAG (p.Asp351Gly) GAAGGCGGATGAAGATAGCATC]

3484 NM_003722.4(TP63):c.1054A>G 8626 TP63 ['GATCTGTGCTTGCCCAGGAAGAGACRGGA (p.Arg352Gly) AGGCGGATGAAGATAGCATCAG]

3485 NM_003742.2(ABCBl l):c.890A> 8647 ABCB11 ['AGAACAGTGGCTGCTTTTGGTGGTGRGAA G (p.Glu297Gly) AAGAGAGGTTGAAAGGTTGGTT]

3486 NM_006702.4(PNPLA6):c.3034A> 10908 PNPLA6 ['GGACCTCACGTACCCAGTCACCTCCRTGTT G (p.Metl012Val) CACTGGGTCTGCCTTTAACCG]

3487 NM_006412.3 ( AGP AT2) : c.589- 10555 AGPAT2 ['GTACACCACGGGGACGATGGGCACCYGCA 2A>G GGCAGGGAGACGCACAGCTGAG]

3488 NM_001084.4(PLOD3):c.668A>G 8985 PLOD 3 ['AAGTCTCGGATCTTTCAGAACCTCARCGGG (p.Asn223Ser) GCTTTAGGTGAGGAGGAAGAC]

3489 NM_138554.4(TLR4):c.896A>G 7099 TLR4 ['GCATACTTAGACTACTACCTCGATGRTATT (p.Asp299Gly) ATTGACTTATTTAATTGTTTG]

3490 NM_001130978.1(DYSF):c.3892A 8291 DYSF ['GGGCCAGGTGCAGGAGACATCAAGGRTCC >G (p.Ilel298Val) TGGATGAGGTGAGCTGGGCGTG]

3491 NM_001130978.1(DYSF):c.5264A 8291 DYSF ['CTTTTTTGTCTTCTCTCTGGGGCAGRGGCT >G (p.Glul755Gly) GGCAGGATCCCAAACCCACAC]

3492 NM_003494.3(DYSF):c3443- 8291 DYSF ['CAGCTCTTAACCACTCCAGCCACTCRCTCT

33A>G GGCACCTCTGTTTTTTCCCTT']

3493 NM_003494.3(DYSF):c.l285- 8291 DYSF ['AACTTGTCCCCTCCCTGTGTCTTCTRGCTGT 2A>G GCAGCAAGATCTTGGAGAAG]

3494 NM_005450.4(NOG):c.665A>G 9241 NOG ['CGCTGCGGCTGGATTCCCATCCAGTRCCCC (p.Tyr222Cys) ATCATTTCCGAGTGCAAGTGC]

3495 NM_004629.1(FANCG):c.925- 2189 FANCG ['GATACAATTTTTTTCTTTCTCTTTTRGGCCT 2A>G TGAATGTCCCATGCAGTTCC]

3496 NM_001701.3(BAAT):c.226A>G 570 BAAT ['AGGGGATTATATGGGAGTCCACCCCRTGG (p.Met76Val) GTCTCTTCTGGTCTCTGAAACC]

3497 NM_006892.3(DNMT3B):c.2450A 1789 DNMT3B ['TTTGGCTTTCCTGTGCACTACACAGRCGTG >G (p.Asp817Gly) TCCAACATGGGCCGTGGTGCC]

3498 NM_001360.2(DHCR7):c.839A>G 1717 DHCR7 ['GCTGCTTCTGTCTTGCAGGCCATCTRCGTG (p.Tyr280Cys) ATTGACTTCTTCTGGAACGAA']

3499 NM_001360.2(DHCR7):c.lA>G 1717 DHCR7 ['AAGGTTCTCTTTCTTGCAGGGCCCARTGGC (p.MetlVal) TGCAAAATCGCAACCCAACAT']

3500 NM_032119.3(ADGRVl):c.18131 84059 ADGRV1 ['TATCATCAGAGCATGTCACAGATCTRTGGA A>G (p.Tyr6044Cys) CTCATTCATGGTGACCTGTAA]

3501 M_004984.2(KIF5A):c.767A>G 3798 KIF5A ['GTGCTGGACGAGGCAAAGAATATCARCAA (p.Asn256Ser) GTCACTGTCAGCTCTGGGCAAT']

3502 M_004984.2(KIF5A):c.827A>G 3798 KIF5A ['GTCTCCTTCCTCCCCCAGAAAAGCTRTGTT (p.Tyr276Cys) CCATATCGTGACAGCAAAATG]

3503 NM_007373.3(SHOC2):c.4A>G 8036 SHOC2 ['TTTTGTCCAGGCTTGAGTCACCATGRGTAG (p.Ser2Gly) TAGTTTAGGAAAAGAAAAAGA']

3504 NM_016203.3(PRKAG2):c.1148A> 51422 PRKAG2 ['TACTCCTTGATCAAAAATAAAATCCRCAG G (p.His383Arg) ATTGCCCGTTATTGACCCTATC]

3505 NM_016203.3 (PRKAG2) : c.1589 A> 51422 PRKAG2 ['GTCCTGCTTTTCTCTTTGCAGGTCCRTCGG G (p.His530Arg) CTGGTGGTGGTAAATGAAGCA']

3506 NM_003816.2(ADAM9):c.411- 8754 ADAM9 ['TTAAAATTTGTATACGTGTAATGCARCATT 8A>G CAGAGGATTGCTGCATTTAGA]

3507 NM_003002.3(SDHD):c.341A>G 6392 SDHD ['GGCCTTGGACAAGTTGTTACTGACTRTGTT (p.Tyrl l4Cys) CATGGGGATGCCTTGCAGAAA]

3508 NM_003002.3(SDHD):c.l49A>G 6392 SDHD ['GAATGGTGTGGAGTGCAGCACATACRCTT (p.His50Arg) GTCACCGAGCCACCATTGTATG]

3509 NM_003002.3(SDHD):c.lA>G 6392 SDHD ['ATGACCTTGAGCCCTCAGGAACGAGDTGG (p.MetlVal) CGGTTCTCTGGAGGCTGAGTGC]

3510 NM_002485.4(NBN):c.511A>G 4683 NBN ['TCAGTAAAATATTCTGGCTTTACAAYTGGA (p.Ilel71Val) CGTCCACAAATGAGTGCACAT']

3511 NM_170695.3(TGIFl):c.838A>G 7050 TGIF1 ['TTCCTGTACAGCTGGGCCAAACCCARCCCT (p.Thr280Ala) AGGGAGGCCACTGTCTCCTAA']

3512 NM_002408.3(MGAT2):c.785A>G 4247 MGAT2 ['CTTATACTTTTCCTAGAAGAGGATCRCTAC (p.His262Arg) TTAGCCCCAGACTTTTACCAT']

3513 NM_002408.3(MGAT2):c.952A>G 4247 MGAT2 ['GAAAACTTGGAAATCCACAGAGCACRATA (p.Asn318Asp) TGGGTCTAGCCTTGACCCGGAA']

3514 NM_005422.2(TECTA):c.5609A> 7007 TECTA ['CAGTCCAATGGCACGCATATCATGTRTAA G (p.Tyrl870Cys) AAACACACTCTGGATCGAAAGC]

3515 NM_012233.2(RAB3GAPl):c.649- 22930 RAB3GAP ['GGTATTGTCTTTGCATGTATTTCCTRGGGA 2A>G 1 TGTCCTTTAACTCCATTGCCT']

3516 NM_005025.4(SERPINIl):c. l013A 5274 SERPINI1 ['GAGATTTTTCTTTCCAAAGCAATTCRCAAG >G (p.His338Arg) TCCTTCCTAGAGGTTAATGAA']

3517 NM_001040667.2(HSF4):c.256A> 3299 HSF4 ['AGACGGTTTTCGGAAGGTGGTGAGCRTCG G (p.Ile86Val) AGCAGGGCGGCCTGCTTAGGCC]

3518 NM_001008211.1(OPTN):c.l433A 10133 OPTN ['GTTTACTGTTCTGATTTTCATGCTGRAAGA >G (p.Glu478Gly) GCAGCGAGAGAGAAAATTCAT']

3519 NM_000492.3(CFTR):c.2738A>G 1080 CFTR ['GTGATTATCACCAGCACCAGTTCGTRTTAT (p.Tyr913Cys) GTGTTTTACATTTACGTGGGA']

3520 NM_000492.3(CFTR):c.3717+4A> 1080 CFTR ['CTCAATAAGTCCTGGCCAGAGGGTGRGAT G TTGAACACTGCTTGCTTTGTTA]

3521 NM_000492.3 (CFTR) : c.1666 A>G 1080 CFTR ['ACTGAGTGGAGGTCAACGAGCAAGARTTT (p.Ile556Val) CTTTAGCAAGGTGAATAACTAA']

3522 NM_000492.3(CFTR):c.326A>G 1080 CFTR ['TTACTGGGAAGAATCATAGCTTCCTRTGAC (p.Tyrl09Cys) CCGGATAACAAGGAGGAACGC]

3523 NM_000492.3(CFTR):c.273+4A>G 1080 CFTR ['TGGAATCTTTTTATATTTAGGGGTARGGAT

CTCATTTGTACATTCATTATG]

3524 NM_000492.3(CFTR):c.3254A>G 1080 CFTR ['CTGTTCCACAAAGCTCTGAATTTACRTACT (p.Hisl085Arg) GCCAACTGGTTCTTGTACCTG]

3525 NM_000492.3 (CFTR) : c.3700 A>G 1080 CFTR ['CATATTAGAGAACATTTCCTTCTCANTAAG (p.Ilel234Val) TCCTGGCCAGAGGGTGAGATT']

3526 NM_000492.3(CFTR):c.650A>G 1080 CFTR ['GCACTCCTCATGGGGCTAATCTGGGRGTTG (p.Glu217Gly) TTACAGGCGTCTGCCTTCTGT']

3527 NM_001005360.2(DNM2):c. l684A 1785 DNM2 ['CCTCCACCCTCAGGAGAAAGAGAAGRAGT >G (p.Lys562Glu) ACATGCTGCCTCTGGACAACCT']

3528 NM_001814.4(CTSC):c.857A>G 1075 CTSC ['TCTCAGACCCCAATCCTAAGCCCTCRGGAG (p.Gln286Arg) GTTGTGTCTTGTAGCCAGTAT']

3529 NM_001814.4(CTSC):c.l235A>G 1075 CTSC ['AATCATGCTGTTCTGCTTGTGGGCTRTGGC (p.Tyr412Cys) ACTGACTCAGCCTCTGGGATG]

3530 NM_001814.4(CTSC):c.l040A>G 1075 CTSC ['CGTTATTACTCCTCTGAGTACCACTRTGTA (p.Tyr347Cys) GGAGGTTTCTATGGAGGCTGC]

3531 M_005144.4(HR):c.-218A>G 55806 HR ['TCCGACCCCTCCAACCTGCGGCCCTRGAGC

GCCCCCGCCGCCCCGGGGGAA']

3532 NM_172107.2(KCNQ2):c.851A>G 3785 KCNQ2 ['ACCACCATTGGCTACGGGGACAAGTRCCC (p.Tyr284Cys) CCAGACCTGGAACGGCAGGCTC]

3533 NM_001303.3(COX10):c.l007A>G 1352 COX10 ['GCCCTGAGCTGGGGCCTCCGTGAAGDCTA (p.Asp336Gly) CTCCCGGGGCGGCTACTGCATG]

3534 NM_006214.3 (PHYH) :c .135 -2 A>G 5264 PHYH ['AGAACGTTATTATCCAGAGTATACCYAAA

GGAGAAAAAGAATCCCAAAATA']

3535 NM_002284.3(KRT86):c.340A>G -1 ['GGAGAAGGAGCAGATCAAGTCCCTCVACA (p.Asnl l4Asp) GCAGGTTCGCGGCCTTCATCGA']

3536 NM_003865.2(HESXl):c.541A>G 8820 HESX1 ['TCTAATGGCGAAAAAAAATTTCAACRCAA (p.Thrl81Ala) ATCTGCTGGAATAGATAGAAAA']

3537 NM_000303.2(PMM2):c.563A>G 5373 PMM2 ['TTTGATGTCTTTCCTGATGGATGGGRCAAG (p.Aspl88Gly) AGATACTGTCTGCGACATGTG]

3538 NM_000288.3(PEX7):c.340- 5191 PEX7 ['TCTTTTGCTTTCTAAACACTTTTCARTGTTT 10A>G TTAGGTGTATAGTGTTGATT']

3539 M_004044.6(ATIC):c.l277A>G 471 ATIC ['CTCATCGTAGCCACCATTGCTGTCARGTAC (p.Lys426Arg) ACTCAGTCTAACTCTGTGTGC]

3540 NM_000314.6(PTEN):c.368A>G 5728 PTEN ['GATGACAATCATGTTGCAGCAATTCRCTGT (p.Hisl23Arg) AAAGCTGGAAAGGGACGAACT']

3541 NM_000314.6(PTEN):c.278A>G 5728 PTEN ['GTTGCACAATATCCTTTTGAAGACCRTAAC (p.His93Arg) CCACCACAGCTAGAACTTATC]

3542 NM_000314.6(PTEN):c.755A>G 5728 PTEN ['CCTCAGCCGTTACCTGTGTGTGGTGRTATC (p.Asp252Gly) AAAGTAGAGTTCTTCCACAAA']

3543 NM_018488.2(TBX4):c.l592A>G 9496 TBX4 ['TCCTTGTCCCGAGAATCTTCCTTACRGTAC (p.Gln531Arg) CATTCAGGAATGGGGACTGTG]

3544 NM_000223.3(KRT12):c.403A>G 3859 KRT12 ['AGAAACTATGCAAAATCTTAATGATRGAT (p.Argl35Gly) TAGCTTCCTACCTGGATAAGGT']

3545 NM_000503.5(EYAl):c. l639A>G 2138 EYA1 ['TGAGAGAATAATTCAAAGGTTTGGARGAA (p.Arg547Gly) AAGTGGTGTATGTTGTTATAGG]

3546 NM 000261.1 (MYOC) : c.1010 A>G 4653 MYOC ['GTGTACTCGGGGAGCCTCTATTTCCRGGGC (p.Gln337Arg) GCTGAGTCCAGAACTGTCATA']

3547 NM 000261.1 (MYOC) : c.1267 A>G 4653 MYOC ['ACAAACCTGGGAGACAAACATCCGTRAGC (p.Lys423Glu) AGTCAGTCGCCAATGCCTTCAT']

3548 M_000474.3(TWISTl):c.466A>G 7291 TWIST1 ['GACCCTCAAGCTGGCGGCCAGGTACRTCG (p.Ilel56Val) ACTTCCTCTACCAGGTCCTCCA']

3549 NM_001089.2(ABCA3):c. l702A> 21 ABC A3 ['ACAGATCACCGTCCTGCTGGGCCACRACG G (p.Asn568Asp) GTGCCGGGAAGACCACCACCCT']

3550 NM_005055.4(RAPSN):c.-210A>G 5913 RAPSN ['ATTCCTCAGAGGCCATGTGGCCCCARCTGG CAGCGACAGCTGCAGACGGGC]

3551 NM_198217.2(INGl):c.515A>G 3621 ING1 ['AACGAACCCACGTACTGTCTGTGCARCCA (p.Asnl72Ser) GGTCTCCTATGGGGAGATGATC]

3552 NM_000430.3(PAFAHlBl):c.446A 5048 PAFAH1B ['GATTTTGAACGAACTCTTAAAGGACRTAC >G (p.Hisl49Arg) 1 AGACTCTGTACAGGACATTTCA']

3553 NM_000579.3(CCR5):c- -1 ['TACGGGGAGAGTGGAGAAAAAGGGGRCA 301+246A>G CAGGGTTAATGTGAAGTCCAGGA']

3554 NM_000264.3(PTCHl):c.2479A>G -1 ['ACTTTACGACCTACACAGGAGTTTCRGTAA (p.Ser827Gly) CGTGAAGTATGTCATGTTGGA']

3555 NM_001184.3 ( ATR) : c.2022 A>G 545 ATR ['TCTGCTGCTGCAATAAGATAAAAAAYCCA (p.Gly674=) CTAACACAACTAGCCCGGATTA]

3556 NM_005982.3(SIXl):c.386A>G 6495 SIX1 ['ATCTGGGACGGCGAGGAGACCAGCTRCTG (p.Tyrl29Cys) CTTCAAGGAGAAGTCGAGGGGT']

3557 NM_006267.4(RANBP2):c.l966A> 5903 RANBP2 ['AGAAGACGCACACATAACTTTTGCTRTATT G (p.Ile656Val) GGATGCAGTAAATGGAAATAT']

3558 NM_001001557.2(GDF6):c.l271A 39225 GDF6 ['CCGCCCAGCTGCTGCGTGCCCACCARATTG >G (p.Lys424Arg) 5 ACTCCCATCAGCATTCTATAC]

3559 NM_000557.4(GDF5):c.517A>G 8200 GDF5 ['ACCCCCCATCACACCCCACGAGTACVTGCT (p.Metl73Val) CTCGCTGTACAGGACGCTGTC]

3560 NM_000392.4(ABCC2):c.4145A> 1244 ABCC2 ['CGAGAGAAGCTGACCATCATCCCCCRGGT G (p.Glnl382Arg) GAGCTCTAGAACTTACTCGGGC]

3561 NM_000396.3(CTSK):c.990A>G 1513 CTSK ['ACCTGGCCAGCTTCCCCAAGATGTGRCTCC (p.Ter330Trp) AGCCAGCCAAATCCATCCTGC]

3562 NM_001127221.1 (C ACN Al A) : c .4 773 CACNA1A ['AACGTCTTCAACATCCTCATCGTCTRCATG 151A>G (p.Tyrl384Cys) CTATTCATGTTCATCTTCGCC]

3563 NM_000178.2(GSS):c.656A>G 2937 GSS ['CAAGAGAAGGAAAGAAACATATTTGRCCA (p.Asp219Gly) GCGTGCCATAGAGAATGAGCTA']

3564 NM_000901.4(NR3C2):c.2327A>G 4306 NR3C2 ['ACGCTCAACCGCTTAGCAGGCAAACRGAT (p.Gln776Arg) GATCCAAGTCGTGAAGTGGGCA']

3565 NM_000901.4(NR3C2):c.2915A>G 4306 NR3C2 ['ATCAGCGACCAGCTGCCCAAGGTGGRGTC (p.Glu972Gly) GGGGAACGCCAAGCCGCTCTAC]

3566 M_004407.3 (DMP 1 ) : c.1 A>G 1758 DMP1 ['CCAGGTAGAGGTATCACACCCAACTRTGA (p.MetlVal) AGATCAGCATCCTGCTCATGTT']

3567 NM_004999.3(MYO6):c.737A>G 4646 MY06 ['CAAGGCAAAGAGGAAAGAAATTATCRTAT (p.His246Arg) CTTTTATAGGTTGTGTGCTGGT']

3568 NM_000256.3(MYBPC3):c.l75A> 4607 MYBPC3 ['CGCCAGCAACAAGTACGGCCTGGCCRCAG G (p.Thr59Ala) AGGGCACACGGCATACGCTGAC]

3569 NM_000163.4(GHR):c.594A>G 2690 GHR ['TGGAGTATGAACTTCAATACAAAGARGTA (p.Glul98=) AATGAAACTAAATGGAAAATGG]

3570 NM_000525.3(KCNJl l):c.509A>G 3767 KCNJ11 ['ATCATGCTTGGCTGCATCTTCATGARGACT (p.Lysl70Arg) GCCCAAGCCCACCGCAGGGCT']

3571 NM_000525.3(KCNJl l):c.776A>G 3767 KCNJ11 ['CTGGTGGCCCCGCTGATCATCTACCRTGTC (p.His259Arg) ATTGATGCCAACAGCCCACTC]

3572 NM_000182.4(H ADH A) : c .180+3 A 3030 HADHA ['GAAAAAAACTGCAAATTAAATGAGAYACC >G TTTGAATTGGGAGAGTTAATTC']

3573 NM_005263.3(GFIl):c.l l45A>G 2672 GFI1 ['GGCAAGGCATTCAGCCAGAGCTCCARCCT (p.Asn382Ser) CATCACCCACAGCCGCAAACAC]

3574 NM_005263.3(GFIl):c.l208A>G 2672 GFI1 ['CCCTTCGGCTGCGACCTCTGTGGGARGGGT (p.Lys403Arg) TTCCAGAGGAAGGTGGACCTC]

3575 NM_001893.4(CSNKlD):c.l30A> 1453 CSNK1D ['TGCCATCAAGCTTGAATGTGTCAAARCCA G (p.Thr44Ala) AACACCCTCAGCTCCACATTGA']

3576 NM_006204.3(PDE6C):c.l363A>G 5146 PDE6C ['AAACAGAAAGGACATTGCTCAGGAARTGC (p.Met455Val) TCATGAACCAAACCAAAGCCAC]

3577 NM_006204.3(PDE6C):c.l483- 5146 PDE6C ['TGAAACAACCCATCCTTATTTCAACRGAAA 2A>G GAGGACTTGCCAGACCCACGC]

3578 NM_003476.4(CSRP3):c.206A>G 8048 CSRP3 ['TGCTATGGGCGCAGATATGGCCCCARAGG (p.Lys69Arg) GATCGGGTATGGACAAGGCGCT']

3579 NM_005591.3(MREllA):c.350A> 4361 MRE11A ['GTGAACTATCAAGATGGCAACCTCARCAT G (p.Asnl l7Ser) TTCAATTCCAGTGTTTAGTATT']

3580 NM_000107.2(DDB2):c.730A>G 1643 DDB2 ['TTGGAATCTCAGAATGCACAAAAAGRAAG (p.Lys244Glu) TGACGCATGTGGCCCTGAACCC]

3581 NM_001204.6(BMPR2):c.l454A> 659 BMPR2 ['AAGGAGACAATCGAAGACTGTTGGGRCCA G (p.Asp485Gly) GGATGCAGAGGCTCGGCTTACT']

3582 NM_000336.2(SCNNlB):c.863A> 6338 SCNN1B ['ACAGAGAAGGCACTTCCTTCGGCCARCCC G (p.Asn288Ser) TGGAACTGAATTCGGTGAGTTT']

3583 M_000447.2(PSEN2):c.715A>G 5664 PSEN2 ['CTACCTCATCATGATCAGTGCGCTCRTGGC (p.Met239Val) CCTAGTGTTCATCAAGTACCT']

3584 NM_002181.3(IHH):c.284A>G 3549 IHH ['CCAGACATCATCTTCAAGGACGAGGRGAA (p.Glu95Gly) CACAGGCGCCGACCGCCTCATG]

3585 NM_000310.3(PPTl):c.236A>G 5538 PPT1 ['ACTTCTCTCTGGCTTCTTTTTTAGGRCGTGG (p.Asp79Gly) AGAACAGCTTCTTCTTGAAT']

3586 NM_003051.3(SLC16Al):c.610A> 6566 SLC16A1 ['GCGACCAATCGGGCCCAAGCCAACCRAGG G (p.Lys204Glu) CAGGGAAAGATAAGTCTAAAGC]

3587 NM_005587.2(MEF2A):c.788A>G 4205 MEF2A ['TCTCCCCCTCCACCAGGTGGTGGTARTCTT (p.Asn263Ser) GGAATGAACAGTAGGAAACCA']

3588 NM_000098.2(CPT2):c.638A>G 1376 CPT2 ['TACCTGGTCAATGCGTATCCCCTGGRTATG (p.Asp213Gly) TCCCAGTATTTTCGGCTTTTC]

3589 NM_000098.2(CPT2):c.359A>G 1376 CPT2 ['TTTTTAGGACCCTGGTTTGATATGTRCCTA (p.Tyrl20Cys) TCTGCTCGAGACTCCGTTGTT']

3590 NM_001079668.2(NKX2-l):c.464- 7080 NKX2-1 ['TCGCCGGGCCCATGAAGCGGGAGACHGTA 2A>G AGCGACAAACGCACAGCGTCGG]

3591 NM_004387.3(NKX2-5):c.896A>G 1482 NKX2-5 ['AACTTCGTGAACTTCGGCGTCGGGGRCTTG (p.Asp299Gly) AATGCGGTTCAGAGCCCCGGG]

3592 NM_004387.3(NKX2-5):c.547A>G 1482 NKX2-5 ['GCTGAAACTCACGTCCACGCAGGTCRAGA (p.Lysl83Glu) TCTGGTTCCAGAACCGGCGCTA]

3593 NM_178138.4(LHX3):c.332A>G 8022 LHX3 ['GTGCGCCGCGCCCAGGACTTCGTGTRCCAC (p.Tyrl l lCys) CTGCACTGCTTTGCCTGCGTC]

3594 NM_001698.2(AUH):c.263-2A>G 549 AUH ['CTTGTACTTTTTTTCCCCTTTAACTRGGAAT TGTGGTGCTTGGAATAAACA]

3595 NM_001698.2(AUH):c.943-2A>G 549 AUH ['ACATATTTAATATTTTGTTTTTCTTRGACCA

TTCCAACAAAAGACAGACTT']

3596 NM_001876.3(CPTlA):c. l361A>G 1374 CPT1A ['ATGTGTGTTTCACGTAGGTGGTTTGRCAAG (p.Asp454Gly) TCGTTCACGTTTGTTGTCTTC]

3597 NM_001876.3(CPTlA):c. l079A>G 1374 CPT1A ['CGGCTGCTGAAGCCCCGGGAGATGGRGCA (p.Glu360Gly) GCAGATGCAGAGGATCCTGGAC]

3598 NM_001876.3(CPTlA):c. l493A>G 1374 CPT1A ['TCCATTGACAGCCTCCAGCTGGGCTRTGCG (p.Tyr498Cys) GAGGATGGGCACTGCAAAGGC]

3599 NM_000352.4(ABCC8):c.4270A> 6833 ABCC8 ['CACCCTGCGCTCACGCCTCTCCATCRTCCT G (p.Ilel424Val) GCAGGACCCCGTCCTCTTCAG]

3600 NM_000352.4(ABCC8):c.215A>G 6833 ABCC8 ['ACATGGCTTCATTTCCCTGGGCACARCCTG (p.Asn72Ser) CGGTGGATCCTGACCTTCATG]

3601 NM_002180.2(IGHMBP2):c.638A> 3508 IGHMBP2 ['TCTCAGAAAGAACTTGCCATCATCCRTGGA G (p.His213Arg) CCTCCTGGCACTGGGAAAACC]

3602 NM_033163.3(FGF8):c.298A>G 2253 FGF8 ['GAAGCACGTGCAGGTCCTGGCCAACRAGC (p.LyslOOGlu) GCATCAACGCCATGGCAGAGGA']

3603 NM_006180.4(NTRK2):c.2165A> 4915 NTRK2 ['TCCCGGGACGTGTACAGCACTGACTRCTAC G (p.Tyr722Cys) AGGGTGAGTAGCTGTGCAGAT']

3604 NM_033028.4(BBS4):c.l57-2A>G 585 BBS4 ['TCAGAAGCATTTTTCTCCCTCTTTCRGGCT

GTTATCAAAGAACAGCTTCAA']

3605 NM_000409.3(GUCAlA):c.296A> 2978 GUCA1A ['AAGCTCCGCTGGTACTTCAAGCTCTRTGAT G (p.Tyr99Cys) GTAGATGGCAACGGCTGCATT']

3606 M_000344.3(SMNl):c.815A>G 6606 SMN1 ['TTAATTTCATGGTACATGAGTGGCTRTCAT (p.Tyr272Cys) ACTGGCTATTATATGGTAAGT']

3607 M_000344.3(SMNl):c.784A>G 6606 SMN1 ['TCTTGATGATGCTGATGCTTTGGGARGTAT (p.Ser262Gly) GTTAATTTCATGGTACATGAG]

3608 NM_000095.2(COMP):c. l358A>G 1311 COMP ['CGGGACAACTGTCCCACGGTGCCTARCAG (p.Asn453Ser) TGCCCAGGAGGACTCAGACCAC]

3609 NM_000095.2(COMP):c. l418A>G 1311 COMP ['GGTGATGCCTGCGACGACGACGACGRCAA (p.Asp473Gly) TGACGGAGTCCCTGACAGTCGG]

3610 NM_002047.2(GARS):c.374A>G 2617 GARS ['GATATTGTAGACCGAGCAAAAATGGRAGA (p.Glul25Gly) TACCCTGAAGAGGAGGTTTTTC]

3611 NM_001166107.1(HMGCS2):c.500 3158 HMGCS2 ['GGCATAGATACCACCAATGCCTGCTRCGG A>G (p.Tyrl67Cys) TGGTACTGCCTCCCTCTTCAAT']

3612 NM_000161.2(GCHl):c.671A>G 2643 GCH1 ['CGAGGTGTACAGAAAATGAACAGCARAAC (p.Lys224Arg) TGTGACCAGCACAATGTTGGGT']

3613 NM_001024630.3(RUNX2):c.598A 860 RUNX2 ['ATCTGCAGGCAAGAGTTTCACCTTGRCCAT >G (p.Thr200Ala) AACCGTCTTCACAAATCCTCC]

3614 NM_000423.2(KRT2):c.556A>G 3849 KRT2 ['AGAGCGTGAGCAGATCAAAACTCTCDACA (p.Asnl86Asp) ACAAATTTGCCTCCTTCATTGA']

3615 NM_000215.3 ( JAK3 ) : c.299 A>G 3718 JAK3 ['GATGCCAGCACCCAAGTCCTGCTGTRCAG (p.TyrlOOCys) GATTCGGTAGGAAGTGCCCCCC]

3616 NM_000335.4(SCN5A):c.3971A>G 6331 SCN5A ['CTCTGTCCACTTGAGGTGGTGGTCARTGCC (p.Asnl324Ser) CTGGTGGGCGCCATCCCGTCC]

3617 NM_000335.4(SCN5A):c.5381A>G 6331 SCN5A ['AGTGAGGACGACTTCGATATGTTCTRTGAG (p.Tyrl794Cys) ATCTGGGAGAAATTTGACCCA]

3618 NM_001014797.2(KCNMAl):c. l3 3778 KCNMA1 ['AAGGACTTTCTGCACAAGGACCGGGRTGA 01A>G (p.Asp434Gly) CGTCAATGTGGAGATCGTTTTT']

3619 NM_004380.2(CREBBP):c.3524A> 1387 CREBBP ['TATAATCGCAAGACATCCCGAGTCTRTAA G (p.Tyrl l75Cys) GTTTTGCAGTAAGCTTGCAGAG]

3620 NM_000023.2(SGCA):c.410A>G 6442 SGCA ['GGCCCCCTGCTGCCATACCAAGCCGRGTTC (p.Glul37Gly) CTGGTGCGCAGCCACGATGCG]

3621 NM_002835.3(PTPN12):c.l82A>G 5782 PTPN12 ['GGAGAAAAAGAAGAAAATGTTAAAARGA (p.Lys61Arg) ACAGATACAAGGACATACTGCCA']

3622 NM_000211.4(ITGB2):c.l052A>G 3689 ITGB2 ['GGGGAGCTGTCTGAGGACTCCAGCARTGT (p.Asn351Ser) GGTCCAACTCATTAAGAATGCT']

3623 NM_005502.3(ABCAl):c. l790A> 19 ABCA1 ['GTCTGGGGGGGCTTCGCCTACTTGCRGGAT G (p.Gln597Arg) GTGGTGGAGCAGGCAATCATC]

3624 NM_005502.3(ABCAl):c.2804A> 19 ABCA1 ['CAGATCACCTCCTTCCTGGGCCACARTGGA G (p.Asn935Ser) GCGGGGAAGACGACCACCATG]

3625 m.5843A>G 4579 MT-TY ['CTCGGAGCTGGTAAAAAGAGGCCTARCCC

CTGTCTTTAGATTTACAGTCCA']

3626 m.7445A>G -1 ['AAGAACCCGTATACATAAAATCTAGVCAA

AAAAGGAAGGAATCGAACCCCC]

3627 m.8344A>G 4566 MT-TK ['ACCTTTTAAGTTAAAGATTAAGAGARCCA

ACACCTCTTTACAGTGAAATGC]

3628 m.8296A>G 4566 MT-TK ['ACCCCCTCTACCCCCTCTAGAGCCCRCTGT

AAAGCTAACTTAGCATTAACC]

3629 m.12320 A>G 4568 MT-TL2 ['TCTTAGGCCCCAAAAATTTTGGTGCRACTC

CAAATAAAAGTAATAACCATG]

3630 m.3243A>G 4567 MT-TL1 ['AGAACAGGGTTTGTTAAGATGGCAGRGCC

CGGTAATCGCATAAAACTTAAA']

3631 m.3252A>G 4567 MT-TL1 ['TTTGTTAAGATGGCAGAGCCCGGTARTCGC

ATAAAACTTAAAACTTTACAG]

3632 m.3251A>G 4567 MT-TL1 ['GTTTGTTAAGATGGCAGAGCCCGGTRATC

GCATAAAACTTAAAACTTTACA']

3633 m.3260A>G 4567 MT-TL1 ['GATGGCAGAGCCCGGTAATCGCATARAAC

TTAAAACTTTACAGTCAGAGGT']

3634 m.3274A>G 4567 MT-TL1 ['GTAATCGCATAAAACTTAAAACTTTRCAGT

CAGAGGTTCAATTCCTCTTCT']

3635 m.4317A>G 4565 MT-TI ['GATAGAGTAAATAATAGGAGCTTAARCCC

CCTTATTTCTAGGACTATGAGA']

3636 m.4269A>G 4565 MT-TI ['GCATTCCCCCTCAAACCTAAGAAATRTGTC

TGATAAAAGAGTTACTTTGAT']

3637 m.4295A>G 4565 MT-TI ['TGTCTGATAAAAGAGTTACTTTGATRGAGT

AAATAATAGGAGCTTAAACCC]

3638 m.4300A>G 4565 MT-TI ['GATAAAAGAGTTACTTTGATAGAGTRAAT AATAGGAGCTTAAACCCCCTTA]

3639 m. l0044A>G 4563 MT-TG ['CTTCCAATTAACTAGTTTTGACAACRTTCA

AA A A AG AGT A AT A A ACTTC GC ']

3640 m.7526A>G 4555 MT-TD ['TCCATGACTTTTTCAAAAAGGTATTRGAAA

AACCATTTCATAACTTTGTCA']

3641 m. l0438A>G 4573 MT-TR ['AGTTTAAACAAAACGAATGATTTCGRCTC

ATTAAATTATGATAATCATATT']

3642 m. l555A>G 4549 MT-RNR1 ['ACCCCTACGCATTTATATAGAGGAGRCAA

GTCGTAACATGGTAAGTGTACT']

3643 m.827A>G 4549 MT-RNR1 ['CACCCCCACGGGAAACAGCAGTGATNARC

CTTTAGCAATAAACGAAAGTTT']

3644 m. l5579A>G 4519 MT-CYB ['CCCGAATGATATTTCCTATTCGCCTRCACA

ATTCTCCGATCCGTCCCTAAC]

3645 m.14495 A>G 4541 MT-ND6 ['TCCAAAGACAACCATCATTCCCCCTRAATA

AATTAAAAAAACTATTAAACC]

3646 m. l2770A>G 4540 MT-ND5 ['CTATTCCAACTGTTCATCGGCTGAGRGGGC

GTAGGAATTATATCCTTCTTG]

3647 m. l l084A>G 4538 MT-ND4 ['CTCCCTACAAATCTCCTTAATTATARCATT

CACAGCCACAGAACTAATCAT']

3648 m.3397A>G 4535 MT-ND1 ['TACCGAACGAAAAATTCTAGGCTATRTAC

AACTACGCAAAGGCCCCAACGT']

3649 m.4136A>G 4535 MT-ND1 ['CTGTTCTTATGAATTCGAACAGCATRCCCC

CGATTCCGCTACGACCAACTC]

3650 m.3796A>G 4535 MT-ND1 ['CCGTTTACTCAATCCTCTGATCAGGNTGAG

CATCAAACTCAAACTACGCCC,

3654 ATAAGTGGCTCCTTTAACCTCTCCDCCCTT

ATCACAACACAAGAACACCT',

CCCCCTTGACCTTGCCGAAGGGGANTCCG

AACTAGTCTCAGGCTTCAACA',

'CGAATACGCCGCAGGCCCCTTCGCCNTATT

CTTCATAGCCGAATACACAAA,

TTTTGTCACCAAGACCCTACTTCTNACCTC

CCTGTTCTTATGAATTCGAA']

3655 NM_003334.3(UBAl):c.l639A>G 7317 UBA1 ['AATGAATCCACATATCCGGGTGACARGCC (p.Ser547Gly) ACCAGAACCGTGTGGGTCCTGA']

3656 NM_000354.5(SERPINA7):c.623- 6906 SERPINA7 ['GATCAAAAGGATTTGCCCACTGGGCYTAA 2A>G AATACAAAGAAAAGAGAGGTGT']

3657 M_000044.3(AR):c.2291A>G 367 AR ['ACCAATGTCAACTCCAGGATGCTCTRCTTC (p.Tyr764Cys) GCCCCTGATCTGGTTTTCAAT']

3658 M_000044.3(AR):c.2362A>G 367 AR ['CCGGATGTACAGCCAGTGTGTCCGARTGA (p.Met788Val) GGCACCTCTCTCAAGAGTTTGG]

3659 M_000044.3(AR):c.2632A>G 367 AR ['GATTGCGAGAGAGCTGCATCAGTTCRCTTT (p.Thr878Ala) TGACCTGCTAATCAAGTCACA]

3660 M_000044.3(AR):c.2708A>G 367 AR ['ATGATGGCAGAGATCATCTCTGTGCRAGT (p.Gln903Arg) GCCCAAGATCCTTTCTGGGAAA]

3661 NM_002764.3(PRPSl):c.341A>G 5631 PRPS1 ['CCAATCTCAGCCAAGCTTGTTGCAARTATG (p.Asnl l4Ser) CTATCTGTAGCAGGTGCAGAT']

3662 NM_000194.2(HPRTl):c.602A>G 3251 HPRT1 ['CTTGACTATAATGAATACTTCAGGGRTTTG (p.Asp201Gly) AATGTAAGTAATTGCTTCTTT']

3663 NM_000194.2(HPRTl):c.l55A>G 3251 HPRT1 ['TGTAGGACTGAACGTCTTGCTCGAGRTGTG (p.Asp52Gly) ATGAAGGAGATGGGAGGCCAT']

3664 NM_000132.3(F8):c.872A>G 2157 F8 ['CCTGAAGTGCACTCAATATTCCTCGRAGGT (p.Glu291Gly) CACACATTTCTTGTGAGGAAC]

3665 NM_000132.3(F8):c.5183A>G 2157 F8 ['GCTGCAGTGGAGAGGCTCTGGGATTRTGG (p.Tyrl728Cys) GATGAGTAGCTCCCCACATGTT']

3666 NM_000132.3(F8):c.5821A>G 2157 F8 ['TTCTCTGTGTCCTTCTCCAGCAATCRATGG (p.Asnl941Asp) CTACATAATGGATACACTACC]

3667 NM_000132.3(F8):c.328A>G 2157 F8 ['TACAGTGGTCATTACACTTAAGAACRTGGC (p.Metl lOVal) TTCCCATCCTGTCAGTCTTCA]

3668 NM_000132.3(F8):c.398A>G 2157 F8 ['TTTCTTCCTGCTATAGGAGCTGAATRTGAT (p.Tyrl33Cys) GATCAGACCAGTCAAAGGGAG]

3669 NM_000132.3(F8):c.404A>G 2157 F8 ['CCTGCTATAGGAGCTGAATATGATGRTCA (p.Aspl35Gly) GACCAGTCAAAGGGAGAAAGAA]

3670 NM_000132.3(F8):c.940A>G 2157 F8 ['GGAAATCTCGCCAATAACTTTCCTTRCTGC (p.Thr314Ala) TCAAACACTCTTGATGGACCT']

3671 NM_000132.3(F8):c.l226A>G 2157 F8 ['TGGGTACATTACATTGCTGCTGAAGRGGA (p.Glu409Gly) GGACTGGGACTATGCTCCCTTA]

3672 NM_000132.3(F8):c.l331A>G 2157 F8 ['CAGCGGATTGGTAGGAAGTACAAAARAGT (p.Lys444Arg) CCGATTTATGGCATACACAGAT']

3673 NM_000132.3(F8):c.l418A>G 2157 F8 ['TCAGGAATCTTGGGACCTTTACTTTRTGGG (p.Tyr473Cys) GAAGTTGGAGACACACTGTTG]

3674 NM_000132.3(F8):c.l660A>G 2157 F8 ['TCGGTGCCTGACCCGCTATTACTCTRGTTT (p.Ser554Gly) CGTTAATATGGAGAGAGATCT']

3675 NM_000132.3(F8):c.l682A>G 2157 F8 ['TCTAGTTTCGTTAATATGGAGAGAGRTCTA (p.Asp561Gly) GCTTCAGGACTCATTGGCCCT']

3676 NM_000132.3(F8):c.l892A>G 2157 F8 ['GAGGATCCAGAGTTCCAAGCCTCCARCAT (p.Asn631Ser) CATGCACAGTGAGTAAAGCAGC]

3677 NM_000132.3(F8):c.5600A>G 2157 F8 ['TTCCCTCCCTAGGAAAAAGATGTGCRCTCA (p.Hisl867Arg) GGCCTGATTGGACCCCTTCTG]

3678 NM_000132.3(F8):c.5822A>G 2157 F8 ['TCTCTGTGTCCTTCTCCAGCAATCARTGGC (p.Asnl941Ser) TACATAATGGATACACTACCT']

3679 NM_000132.3(F8):c.6113A>G 2157 F8 ['AGCACACTTTTTCTGGTGTACAGCARTAGT (p.Asn2038Ser) GAGTAGCAATGTGGGCAGAGG]

3680 NM_000132.3(F8):c.6278A>G 2157 F8 ['AAGTGTTATTTTAATTGGTAGGTGGRTCTG (p.Asp2093Gly) TTGGCACCAATGATTATTCAC]

3681 NM_000132.3(F8):c.6371A>G 2157 F8 ['TACATCTCTCAGTTTATCATCATGTRTAGT

CTTGATGGGAAGAAGTGGCAG]

3682 NM_000132.3(F8):c.6794A>G 2157 F8 ['ATGAAAGTCACAGGAGTAACTACTCRGGG (p.Gln2265Arg) AGTAAAATCTCTGCTTACCAGC]

3683 NM_000132.3(F8):c.l04A>G 2157 F8 ['GGTGCAGTGGAACTGTCATGGGACTRTAT (p.Tyr35Cys) GCAAAGTGATCTCGGTGAGCTG]

3684 NM_000402.4(G6PD):c.466A>G 2539 G6PD ['CAACTCCTATGTGGCTGGCCAGTACRATGA (p.Asnl56Asp) TGCAGCCTCCTACCAGCGCCT']

3685 NM_000402.4(G6PD):c.583A>G 2539 G6PD ['GCTCCGGGCTCCCAGCAGAGGCTGGRACC (p.Asnl95Asp) GCATCATCGTGGAGAAGCCCTT']

3686 NM_002049.3(GATAl):c.653A>G 2623 GATA1 ['ACAGCCACTCCACTGTGGCGGAGGGRCAG (p.Asp218Gly) GACAGGCCACTACCTATGCAAC]

3687 NM_001097642.2(GJBl):c. l94A> 2705 GJB1 ['CAGCCTGGCTGCAACAGCGTTTGCTRTGAC G (p.Tyr65Cys) CAATTCTTCCCCATCTCCCAT']

3688 NM_000166.5(GJBl):c.614A>G 2705 GJB1 ['GCCTCTGGCATCTGCATCATCCTCARTGTG (p.Asn205Ser) GCCGAGGTGGTGTACCTCATC]

3689 NM_000032.4(ALAS2):c.1702A>G 212 ALAS2 ['CCGTCCTGTACACTTTGAGCTCATGRGTGA (p.Ser568Gly) GTGGGAACGTTCCTACTTCGG]

3690 NM_000202.6(IDS):c.404A>G 3423 IDS ['GGCTATGTGACCATGTCGGTGGGAARAGT (p.Lysl35Arg) CTTTCACCCTGGTACTGCTCCA']

3691 NM_000292.2(PHKA2):c.896A>G 5256 PHKA2 ['TATGGATGCTGTCGCTTCCTTCGAGRTGGT (p.Asp299Gly) TATAAAACTCCAAGAGAGGTT']

3692 NM_000292.2(PHKA2):c.565A>G 5256 PHKA2 ['TTATGGAATGTGGGAGCGTGGAGATRAGA (p.Lysl89Glu) CTAATCAGGGCATCCCGGAATT']

3693 NM_000351.4(STS):c. l331A>G 412 STS ['CGCTCCGATCATGAGTTTCTCTTCCRTTAC (p.His444Arg) TGCAACGCCTACTTAAATGCT']

3694 NM_000133.3(F9):c.278A>G 2158 F9 ['TTCAATTTCTTAACCTATCTCAAAGRTGGA (p.Asp93Gly) GATCAGTGTGAGTCCAATCCA']

3695 NM_000133.3(F9):c.329A>G 2158 F9 ['TGTTTAAATGGCGGCAGTTGCAAGGRTGA (p.Aspl lOGly) CATTAATTCCTATGAATGTTGG]

3696 NM_000133.3(F9):c.917A>G 2158 F9 ['CGAATTATTCCTCACCACAACTACARTGCA (p.Asn306Ser) GCTATTAATAAGTACAACCAT']

3697 NM_000133.3(F9):c.l l80A>G 2158 F9 ['TACAAAGTTCACCATCTATAACAACRTGTT (p.Met394Val) CTGTGCTGGCTTCCATGAAGG]

3698 NM_000133.3(F9):c.l231A>G 2158 F9 ['AGGTAGAGATTCATGTCAAGGAGATRGTG (p.Ser411Gly) GGGGACCCCATGTTACTGAAGT']

3699 NM_000266.3 (NDP) :c .131 A>G 4693 NDP ['CCTCGACGCTGCATGAGGCACCACTRTGTG (p.Tyr44Cys) GATTCTATCAGTCACCCATTG]

3700 NM_000266.3 (NDP) :c .1 A>G 4693 NDP ['TCTAGAGAAGTTTTTCCTTACAACARTGAG (p.MetlVal) AAAACATGTACTAGCTGCATC]

3701 NM_000266.3(NDP):c.l25A>G 4693 NDP ['TCGGACCCTCGACGCTGCATGAGGCRCCA (p.His42Arg) CTATGTGGATTCTATCAGTCAC]

3702 NM_000169.2(GLA):c.886A>G -1 ['GGCTATCATGGCTGCTCCTTTATTCRTGTC (p.Met296Val) TAATGACCTCCGACACATCAG]

3703 NM_000169.2(GLA):c. l01A>G -1 ['ATCCCTGGGGCTAGAGCACTGGACARTGG (p.Asn34Ser) ATTGGCAAGGACGCCTACCATG]

3704 NM_000169.2(GLA):c.644A>G -1 - ['GAGTCATATCTGTTTTCACAGCCCARTTAT (p.Asn215Ser) ACAGAAATCCGACAGTACTGC']

3705 NM_000169.2(GLA):c.1228A>G -1 ['AAGGTTAAGAAGTCACATAAATCCCRCAG (p.Thr410Ala) GCACTGTTTTGCTTCAGCTAGA]

3706 NM_000169.2(GLA):c.815A>G -1 ['TCTTTTTCTCAGTTAGTGATTGGCARCTTTG (p.Asn272Ser) GCCTCAGCTGGAATCAGCAA']

3707 NM_153252.4(BRWD3):c.4786A> 25406 BRWD3 ['AGAAGATAAAGAGAAAAAAGAAACARAA G (p.Lysl596Glu) 5 GAGAAATCTCATTTATCCACCTC]

3708 M_004463.2(FGDl):c. l396A>G 2245 FGD1 ['GCAGAAACTGGCCCCCTTCCTCAAGRTGTA (p.Met466Val) TGGTGAGTATGTGAAGAACTT']

3709 NM_000054.4(AVPR2):c.614A>G 554 AVPR2 ['GCGGAGCCCTGGGGCCGTCGCACCTRTGT (p.Tyr205Cys) CACCTGGATTGCCCTGATGGTG]

3710 NM_000054.4(AVPR2):c.839A>G 554 AVPR2 ['ATGACGCTAGTGATTGTGGTCGTCTRTGTG (p.Tyr280Cys) CTGTGCTGGGCACCCTTCTTC]

3711 NM_000276.3(OCRL):c.l436A>G 4952 OCRL ['ATCAAGTTCATCCCCACTTATAAGTRTGAC (p.Tyr479Cys) TCTAAAACAGACCGGTGGGAT']

3712 NM_000397.3(CYBB):c.302A>G 1536 CYBB ['CAACTGGACAGGAATCTCACCTTTCRTAAA (p.HislOlArg) ATGGTGGCATGGATGATTGCA']

3713 NM_000397.3(CYBB):c.l499A>G 1536 CYBB ['GCTGTGCACCATGATGAGGAGAAAGRTGT (p.Asp500Gly) GATCACAGGCCTGAAACAAAAG]

3714 NM_001205019.1(GK):c.880A>G 2710 GK ['TGGAACAGGATGTTTCTTACTATGTRATAC (p.Asn294Asp) AGGCCATAAGGTTGGTTTTTT']

3715 NM_005710.2(PQBPl):c.l94A>G 10084 PQBP1 ['CGGCCCCACAGCGGGCTCCCTTACTRCTGG (p.Tyr65Cys) AATGCAGACACAGACCTTGTA]

3716 NM_198270.3(NHS):c.853-2A>G 4810 NHS ['CTGAACCTGATTGTACTTTGTTTGCRGTCC

CATCCCCCAGAGGATGAAGAT']

3717 NM_000252.2(MTMl):c.566A>G 4534 MTM1 ['CACCATTGGAGAATAACTTTTATTARTAAG (p.Asnl89Ser) TGCTATGAGCTCTGTGACACT']

3718 NM_000252.2(MTMl):c. ll90A>G 4534 MTM1 ['GCCATGCTGATGTTGGATAGCTTCTRTAGG (p.Tyr397Cys) AGCATTGAAGGGTTCGAAATA]

3719 NM_000252.2(MTMl):c. l261- 4534 MTM1 ['TAATTAAAACAAATTATCTTCATCARTTTA 10A>G TTCAGCGAATAGGTCATGGTG]

3720 NM_001015877.1(PHF6):c.700A> 84295 PHF6 ['AGGAAAACTGCATATATTTAATGCCRAGA G (p.Lys234Glu) AGGCAGCTGCCCATTATAAGTG]

3721 NM_001015877.1(PHF6):c.686A> 84295 PHF6 ['GAAAATGAAGCACGAGGAAAACTGCRTAT G (p.His229Arg) ATTTAATGCCAAGAAGGCAGCT']

3722 NM_001015877.1(PHF6):c.769A> 84295 PHF6 ['CACAGTCCAGCTCACAACAACATCARGAG G (p.Arg257Gly) CAGAATTTGGAGACTTTGATAT']

3723 NM_000117.2(EMD):c.1 A>G 2010 EMD ['GCCTCCGCCTGAGCCCGCACCCGCCRTGG (p.MetlVal) ACAACTACGCAGATCTTTCGGA']

3724 NM_004006.2(DMD):c.2317A>G 1756 DMD ['GGCCATAGAGCGAGAAAAAGCTGAGRAGT (p.Lys773Glu) TCAGAAAACTGCAAGATGCCAG]

3725 NM_004006.2(DMD):c.8734A>G 1756 DMD ['TCTACGAAAGCAGGCTGAGGAGGTCRATA (p.Asn2912Asp) CTGAGTGGGAAAAATTGAACCT']

3726 NM_004006.2(DMD):c.8762A>G 1756 DMD ['ACTGAGTGGGAAAAATTGAACCTGCRCTC (p.His2921Arg) CGCTGACTGGCAGAGAAAAATA]

3727 NM_004006.2(DMD):c.835A>G 1756 DMD ['TCCCCCAAACCCTTCTCTGCAGATCRCGGT (p.Thr279Ala) CAGTCTAGCACAGGGATATGA']

3728 NM_004006.2(DMD):c.9225- 1756 DMD ['TCGATCGCACTTCAGTTATGATAAAYTGAC 285A>G CTTGTTATGTGATCAATAATC]

3729 NM_000033.3(ABCDl):c.443A>G 215 ABCD1 ['ATCGCCCTCCCTGCTACCTTCGTCARCAGT (p.Asnl48Ser) GCCATCCGTTACCTGGAGGGC]

3730 NM_003588.3(CUL4B):c.901- 8450 CUL4B ['TTTGATTTCTTTTTTTTTCATTGGCRGATCA 2A>G TGATCAGGAGCATTTTTTTG]

3731 NM_000061.2(BTK):c.l288A>G 695 BTK ['GAGAGGCCAGTACGACGTGGCCATCRAGA (p.Lys430Glu) TGATCAAAGAAGGCTCCATGTC]

3732 NM_000061.2(BTK):c.l082A>G 695 BTK ['AGCACCATCCCTGAGCTCATTAACTRCCAT (p.Tyr361Cys) CAGCACAACTCTGCAGGTGAG]

3733 NM_000061.2(BTK):c.919A>G 695 BTK ['GGGGAAAGAAGGAGGTTTCATTGTCRGAG (p.Arg307Gly) ACTCCAGCAAAGCTGGCAAATA']

3734 NM_000061.2(BTK):c.l766A>G 695 BTK ['CACCTTCTAGGGGTTTTGATGTGGGRAATT (p.Glu589Gly) TACTCCCTGGGGAAGATGCCA']

3735 NM_003413.3(ZIC3):c.l213A>G 7547 ZIC3 ['CTACACGCACCCGAGCTCCCTGCGCRAAC (p.Lys405Glu) ACATGAAGGTAATTACCTCTTT']

3736 NM_001037811.2(HSD17B10):c.71 3028 HSD17B10 ['GCCATCATCGAGAACCCATTCCTCARTGGA 3A>G (p.Asn238Ser) GAGGTCATCCGGCTGGATGGG]

3737 NM_003639.4(TKBKG):c. l219A>G 8517 IKBKG ['CAAGTGCCAGTATCAGGCCCCTGATRTGG (p.Met407Val) ACACCCTGCAGATACATGTCAT']

3738 NM_003639.4(TKBKG):c. l259A>G 8517 IKBKG ['ATACATGTCATGGAGTGCATTGAGTRGGG (p.Ter420Trp) CCGGCCAGTGCAAGGCCACTGC]

3739 M_005448.2(BMP15):c.704A>G 9210 BMP15 ['TTGGACATTGCCTTCTTGTTACTCTRTTTCA (p.Tyr235Cys) ATGATACTCATAAAAGCATT']

3740 NM_005120.2(MED12):c.3020A> 9968 MED 12 ['AAGGTGAAGAACACCATCTACTGCARCGT G (p.Asnl007Ser) GGAGCCATCGGAATCAAATATG]

3741 NM_003688.3(CASK):c.2129A>G 8573 CASK ['GGCAAGAAAAAGAAGCAGTACAAAGRTA (p.Asp710Gly) AATATTTGGCAAAGCACAATGCA]

3742 NM_001363.4(DKCl):c.361A>G 1736 DKC1 ['ACTTCGGGTGGAGAAGACAGGGCACRGTG (p.Serl21Gly) GTACTCTGGATCCCAAGGTGAC]

3743 NM_001363.4(DKCl):c.l069A>G 1736 DKC1 ['ATTAATGACCACAGCGGTCATCTCTRCCTG (p.Thr357Ala) CGACCATGGTATAGTAGCCAA']

3744 NM_000307.4(POU3F4):c.1000A> 5456 POU3F4 ['GTTCTGTAATCGAAGACAAAAAGAGRAAA G (p.Lys334Glu) GAATGACTCCGCCAGGGGATCA']

3745 NM_004429.4(EFNBl):c.472A>G 1947 EFNB1 ['GGGCGGTGTGTGCCGCACACGCACCRTGA (p.Metl58Val) AGATCATCATGAAGGTTGGGCA']

3746 NM_000489.4(ATRX):c.4826A>G 546 ATRX ['TTCTTATAGGTGGTAAGTTTTCTTCRTACA (p.Hisl609Arg) GTTCTTTTGTGTGACAAACTG]

3747 NM_000489.4(ATRX):c.5579A>G 546 ATRX ['TTCTTTTGATCAGGTGTGGGCAATAVTAGT (p.Asnl860Ser) GAAGGTGGAAGAGGAAAGGCA']

3748 NM_000489.4(ATRX):c.6488A>G 546 ATRX ['GGACAAACTAAGCCTGTTTATGTATRTAGG (p.Tyr2163Cys) TTCTTAGCTCAGGTAGGTTTA]

3749 NM_000489.4(ATRX):c.6811A>G 546 ATRX ['AGAAGAAGAGTTGACTGAAGAAGAARGA (p.Arg2271Gly) AAAGCAGCTTGGGCTGAGTATGA]

3750 NM_000052.6(ATP7A):c.3911A>G 538 ATP7A ['GTAGCAATGGTGGGAGATGGAATCARTGA (p.Asnl304Ser) CTCCCCAGCTCTGGCAATGGCT']

3751 NM_004992.3(MECP2):c.410A>G 4204 MECP2 ['GGAAAAGCCTTTCGCTCTAAAGTGGRGTT (p.Glul37Gly) GATTGCGTACTTCGAAAAGGTA']

3752 NM_000137.2(FAH):c. l l41A>G 2184 FAH ['CATAGACCTGGGGAATGGTCAGACCRGGA (p.Arg381Gly) AGTTTCTGCTGGACGGGGATGA']

3753 NM_000137.2(FAH):c.836A>G 2184 FAH ['CCCTTTGCTGTGCCCAACCCGAAGCRGGTA (p.Gln279Arg) AGCACATTCTCTGCAGGAAGC]

3754 NM_002769.4(PRSSl):c.68A>G -1 ['GCTGCCCCCTTTGATGATGATGACARGATC (p.Lys23Arg) GTTGGGGGCTACAACTGTGAG]

3755 NM_002769.4(PRSSl):c. l61A>G -1 ['CACTTCTGTGGTGGCTCCCTCATCARCGAA (p.Asn54Ser) CAGTGGGTGGTATCAGCAGGC]

3756 NM_000373.3(UMPS):c.286A>G 7372 UMPS ['AACCAATCAAATTCCAATGCTTATTRGAAG (p.Arg96Gly) GAAAGAAACAAAGGATTATGG]

3757 NM_001918.3(DBT):c.l355A>G 1629 DBT ['ATGAATGTGAGCTGGTCAGCTGATCRCAG (p.His452Arg) AGTTATTGATGGTGCTACAATG]

3758 NM_000108.4(DLD):c.214A>G 1738 DLD ['TTGGTTGTAGACAGTCTGCATTGAGRAAA (p.Lys72Glu) ATGAAACACTTGGTGGAACATG]

3759 NM_000108.4(DLD):c.l483A>G 1738 DLD ['CTTGCAGACCTTATCAGAAGCTTTTRGAGA (p.Arg495Gly) AGCAAATCTTGCTGCGTCATT']

3760 NM_000108.4(DLD):c.l081A>G 1738 DLD ['CATTGGTGATGTAGTTGCTGGTCCARTGCT (p.Met361Val) GGCTCACAAAGCAGAGGATGA']

3761 NM_000481.3(AMT):c.l25A>G 275 AMT ['CGCAGGACACCGCTCTATGACTTCCRCCTG (p.His42Arg) GCCCACGGCGGGAAAATGGTG]

3762 NM_000151.3(G6PC):c.230+4A>G 2538 G6PC ['GGCTCAACCTCGTCTTTAAGTGGTARGAAC

CATATAGAGAGGAGATCAGCA']

3763 NM_000532.4(PCCB):c.l304A>G 5096 PCCB ['CAGCATTTGGATCTGTTTTAGGCCTRTGGA (p.Tyr435Cys) GGTGCCTATGATGTCATGAGC]

3764 NM_000387.5(SLC25A20):c.713A 788 SLC25A20 ['CCAGATGTGCTCAAGTCTCGATTCCRGACT >G (p.Gln238Arg) GGTGAGTGGAAGGTAGTGGGG]

3765 NM_004360.3(CDHl):c.2512A>G 999 CDH1 ['TCTGCTCGTGTTTGACTATGAAGGARGCGG (p.Ser838Gly) TTCCGAAGCTGCTAGTCTGAG]

3766 NM_004360.3(CDHl):c.l018A>G 999 CDH1 ['GTCGATCTCTCTGCAGAGTTTCCCTDCGTA (p.Thr340Ala) TACCCTGGTGGTTCAAGCTGC]

3767 NM_003361.3(UMOD):c.383A>G 7369 UMOD ['TGCCACGCCCTGGCCACATGTGTCARTGTG (p.Asnl28Ser) GTGGGCAGCTACTTGTGCGTA']

3768 NM_000463.2(UGTlAl):c.992A> -1 ['GCTGATGCTTTGGGCAAAATCCCTCRGACA G (p.Gln331Arg) GTAAGAAGATTCTATACCATG]

3769 NM_000463.2(UGTlAl):c.l085- -1 ['TGACATCCTCCCTATTTTGCATCTCRGGTC 2A>G ACCCGATGACCCGTGCCTTTA]

3770 NM_000463.2(UGTlAl):c.l070A> -1 - ['ACGATACTTGTTAAGTGGCTACCCCRAAAC G (p.Gln357Arg) GATCTGCTTGGTATGTTGGGC]

3771 NM_000463.2(UGTlAl):c.l l98A> -1 ['GCCCTTGTTTGGTGATCAGATGGACVATGC G (p.Asn400Asp) AAAGCGCATGGAGACTAAGGG]

3772 NM_001382.3(DPAGTl):c.509A> 1798 DPAGT1 ['TCTCTCCCCGCAGGAATCCTGTACTRTGTC G (p.Tyrl70Cys) TACATGGGGCTGCTGGCAGTG]

3773 NM_001007792.1(NTRKl):c.986A 4914 NTRK1 ['CCCACCCACGTCAACAACGGCAACTRCAC >G (p.Tyr329Cys) GCTGCTGGCTGCCAACCCCTTC]

3774 NM_001007792.1(NTRKl):c.l651 4914 NTRK1 ['CTGCACCGAGGGCCGCCCCCTGCTCRTGGT A>G (p.Met551Val) CTTTGAGTATATGCGGCACGG]

3775 NM_000363.4(TNNI3):c.569A>G 7137 TNNI3 ['CTCCAGGAAAACCGGGAGGTGGGAGRCTG (p.Aspl90Gly) GCGCAAGAACATCGATGCACTG]

3776 NM_000363.4(TNNI3):c.532A>G 7137 TNNI3 ['GCGGGCCCACCTCAAGCAGGTGAAGRAGG (p.Lysl78Glu) AGGACACCGAGAAGGTGAGTGT']

3777 NM_001018005.1(TPMl):c.539A> 7168 TPM1 ['ATTGAGAGCGACCTGGAACGTGCAGDGGA G (p.Glul80Gly) GCGGGCTGAGCTCTCAGAAGGG]

3778 NM_001159287.1(TPIl):c.622A>G 7167 TPI1 ['CCTGGCCTATGAGCCTGTGTGGGCCRTTGG (p.Ile208Val) TACTGGCAAGACTGCAACACC]

3779 NM_000359.2(TGMl):c.l469A>G 7051 TGM1 ['AATGGCCTGGTCTACATGAAGTACGRCAC (p.Asp490Gly) GCCTTTCATTTTTGCTGAGGTG]

3780 NM_001024847.2(TGFBR2):c. l47 7048 TGFBR2 ['CCCTGTGTTTGCTGGCTTTCTTCACRGAAG 2-2A>G TAAAAGATTATGAGCCTCCAT']

3781 NM_003242.5(TGFBR2):c.1273 A> 7048 TGFBR2 ['GCTATAGGTGGGAACTGCAAGATACRTGG G (p.Met425Val) CTCCAGAAGTCCTAGAATCCAG]

3782 NM_004612.3(TGFBRl):c. l l99A> 7046 TGFBR1 ['CATTTTGAATCCTTCAAACGTGCTGRCATC G (p.Asp400Gly) TATGCAATGGGCTTAGTATTC]

3783 NM_001128177.1(THRB):c.l324A 7068 THRB ['CTGCCATGCCAGCCGCTTCCTGCACRTGAA >G (p.Met442Val) GGTGGAATGCCCCACAGAACT']

3784 NM_001128177.1(THRB):c.l327A 7068 THRB ['CCATGCCAGCCGCTTCCTGCACATGRAGGT >G (p.Lys443Glu) GGAATGCCCCACAGAACTCTT']

3785 NM_001128177.1(THRB):c.l009A 7068 THRB ['AACCTTGAATGGGGAAATGGCAGTGRCAC >G (p.Thr337Ala) GGGGCCAGCTGAAAAATGGGGG]

3786 NM_033360.3(KRAS):c.l3A>G 3845 KRAS ['AGGCCTGCTGAAAATGACTGAATATRAAC (p.Lys5Glu) TTGTGGTAGTTGGAGCTGGTGG]

3787 NM_005343.2(HRAS):c.350A>G -1 ['GTGCCCATGGTGCTGGTGGGGAACARGTG (p.Lysl l7Arg) TGACCTGGCTGCACGCACTGTG]

3788 NM_001063.3(TF):c.956A>G 7018 TF ['GACCTGCTGTTTAAGGACTCTGCCCRCGGG (p.His319Arg) TTTTTAAAAGTCCCCCCCAGG]

3789 NM_001063.3(TF):c.l936A>G 7018 TF ['CTTTTGTTTGTTCCGGTCGGAAACCRAGGA (p.Lys646Glu) CCTTCTGTTCAGAGATGACAC]

3790 NM_212472.2(PRKARlA):c.891+3 5573 PRKARIA ['ATGAGTTCTTCATTATTTTAGAGGTRAAGA A>G ACTCAGAATTTAATACTTGAA']

3791 NM_212472.2(PRKARlA):c.lA>G 5573 PRKARIA ['GTGTGTTTTTTTCTCGCAGAGAACCRTGGA (p.MetlVal) GTCTGGCAGTACCGCCGCCAG]

3792 NM_000362.4(TIMP3):c.572A>G -1 - ['GCCTGCATCCGGCAGAAGGGCGGCTRCTG (p.Tyrl91Cys) CAGCTGGTACCGAGGATGGGCC]

3793 NM_000367.3(TPMT):c.719A>G 7172 TPMT ['GATTACAGGTGTGAGCCACCGCACCNAGC (p.Tyr240Cys) C A ATTTT GAGT ATTTTT A A A AG ,

3795 'TAACATGTTACTCTTTCTTGTTTCARGTAAA

ATATGCAATATACRTYGTCT',

AGGTTGATGCTTTTGAAGAACGACAKAAAA

GTTGGGGAATTGACTGTCTTT']

3796 NM_198253.2(TERT):c.2315A>G 7015 TERT ['TCTACCTTGACAGACCTCCAGCCGTRCATG (p.Tyr772Cys) CGACAGTTCGTGGCTCACCTG]

3797 NM_000073.2(CD3G):c. lA>G 917 CD3G ['CTTTTGCCGGAGGACAGAGACTGACRTGG (p.MetlVal) AACAGGGGAAGGGCCTGGCTGT']

3798 NM_000899.4(KITLG):c.l07A>G 4254 KITLG ['ATCTGCAGGAATCGTGTGACTAATARTGTA (p.Asn36Ser) AAAGACGTCACTAAATTGGTA]

3799 NM_001024858.2(SPTB):c.lA>G 6710 SPTB ['GCGGAGCTGCTAAGAGCCTGCTGACRTGA (p.MetlVal) CATCGGCCACAGAGTTTGAAAA']

3800 NM_003126.2(SPTAl):c.l43A>G 6708 SPTA1 ['GAGCGGGTCGCTGAGAGGGGTCAGARGCT (p.Lys48Arg) TGAGGATTCCTATCACTTACAA']

3801 NM_005633.3(SOSl):c.l654A>G 6654 SOS1 ['TTTACAGTACCGGAGTACACTGGAARGGA (p.Arg552Gly) TGCTTGATGTAACAATGCTACA']

3802 NM_003041.3(SLC5A2):c.l961A> -1 ['GACCCGAGCTGGGCCCGTGTGGTCARCCT G (p.Asn654Ser) CAATGCCCTGCTCATGATGGCA']

3803 NM_000343.3(SLC5Al):c.83A>G 6523 SLC5A1 ['CACGAGCTCATTCGCAATGCAGCCGRTATC (p.Asp28Gly) TCCATCATCGTTATCTACTTC]

3804 NM_000702.3(ATPlA2):c. l033A> 477 ATP1A2 ['TCTCTACCAGGTGTGCCTGACCCTGRCAGC G (p.Thr345Ala) CAAGCGCATGGCACGGAAGAA']

3805 NM_003124.4(SPR):c.448A>G 6697 SPR ['CTTCCCGGACAGTCCTGGCCTCAACRGAAC (p.Argl50Gly) CGTGGTTAACATCTCGTCCCT']

3806 NM_001161766.1 ( AHCY) :c .344 A> 191 AHCY ['CTCACCAACCTCATCCACACCAAGTRCCCG G (p.Tyrl l5Cys) CAGCTTCTGCCAGGTGAGCAG]

3807 NM_001035.2(RYR2):c.l2602A>G 6262 RYR2 ['TGCGAGGACACCATCTTTGAAATGCRGCT (p.Gln4201Arg) GGCGGCTCAGATCTCGGAGTCG]

3808 NM_000540.2(RYRl):c.14387 A>G 6261 RYRl ['CAGTCCTTCCTGTACCTGGGCTGGTRTATG (p.Tyr4796Cys) GTGATGTCCCTCTTGGGACAC]

3809 NM_000540.2(RYRl):c.14647- 6261 RYRl ['CTCTGTCTCAAAAAAAAAAAAAAACRTAT 1449A>G GTAAAGTTGTTCCCAAATGCCA']

3810 NM_000540.2(RYRl):c.l3909A>G 6261 RYRl ['GGTGTACTACTTCCTGGAGGAAAGCRCAG (p.Thr4637Ala) GCTACATGGAACCCGCCCTGCG]

3811 NM_000539.3(RHO):c.533A>G 6010 RHO ['TCTCCCTACCTGCCTGTCCTCAGGTRCATC (p.Tyrl78Cys) CCCGAGGGCCTGCAGTGCTCG]

3812 NM_000539.3(RHO):c.569A>G 6010 RHO ['GGCCTGCAGTGCTCGTGTGGAATCGRCTAC (p.Aspl90Gly) TACACGCTCAAGCCGGAGGTC]

3813 NM_000539.3(RHO):c.886A>G 6010 RHO ['CATGACCATCCCAGCGTTCTTTGCCRAGAG (p.Lys296Glu) CGCCGCCATCTACAACCCTGT']

3814 NM_000539.3(RHO):c.44A>G 6010 RHO ['CCTAACTTCTACGTGCCCTTCTCCARTGCG (p.Asnl5Ser) ACGGGTGTGGTACGCAGCCCC]

3815 NM_000321.2(RBl):c.2490- 5925 RBI ['AAGGGTGCTGTGGATCAGGGAAATGRTGA 1398A>G GTATGAAGCTGTTTTAAATTCT']

3816 NM_000536.3(RAG2):c. l l5A>G 5897 RAG2 ['CTTTGGACAAAAAGGCTGGCCCAAARGAT (p.Arg39Gly) CCTGCCCCACTGGAGTTTTCCA']

3817 M_000448.2(RAGl):c.2735A>G 5896 RAG1 ['GAGTGCCCAGAATCCCTCTGCCAGTRCAGT (p.Tyr912Cys) TTCAATTCACAGCGTTTTGCT']

3818 M_000448.2(RAGl):c.1286A>G 5896 RAG1 ['TTTGCTGACAAAGAAGAAGGTGGAGRTGT (p.Asp429Gly) GAAGTCCGTGTGCATGACCTTG]

3819 NM_000925.3(PDHB):c.395A>G 5162 PDHB ['ATAAACTCAGCTGCCAAGACCTACTRCAT (p.Tyrl32Cys) GTCTGGTGGCCTTCAGCCTGTG]

3820 NM_000055.2(BCHE):c.293A>G 590 BCHE ['GCAAATTCTTGCTGTCAGAACATAGRTCAA (p.Asp98Gly) AGTTTTCCAGGCTTCCATGGA]

3821 NM_000055.2(BCHE):c.467A>G 590 BCHE ['ACTGGAACATCATCTTTACATGTTTDTGAT (p.Tyrl56Cys) GGCAAGTTTCTGGCTCGGGTT']

3822 NM_005360.4(MAF):c.890A>G 4094 MAF ['CTGAAGCAGAAGAGGCGGACCCTGARAAA (p.Lys297Arg) CCGCGGCTATGCCCAGTCCTGC]

3823 NM_002739.3(PRKCG):c.380A>G 5582 PRKCG ['TCCCTCCTCTACGGGCTTGTGCACCRGGGC (p.Glnl27Arg) ATGAAATGCTCCTGTGAGTGA']

3824 NM_002739.3(PRKCG):c. l081A> 5582 PRKCG ['CTTCCTCATGGTTCTAGGAAAAGGCRGTTT G (p.Ser361Gly) TGGGAAGGTTGGATTCCTGGG]

3825 NM_000141.4(FGFR2):c.983A>G 2263 FGFR2 ['ACGGACAAAGAGATTGAGGTTCTCTRTATT (p.Tyr328Cys) CGGAATGTAACTTTTGAGGAC]

3826 NM_000141.4(FGFR2):c.1124 A>G 2263 FGFR2 ['AAGGAGATTACAGCTTCCCCAGACTRCCT (p.Tyr375Cys) GGAGATAGCCATTTACTGCATA']

3827 NM_000141.4(FGFR2):c.874A>G 2263 FGFR2 ['TGCCCAGCCCCACATCCAGTGGATCRAGC (p.Lys292Glu) ACGTGGAAAAGAACGGCAGTAA']

3828 NM_000141.4(FGFR2):c. l576A>G 2263 FGFR2 ['ACTGTTCATAGATGATGCCACAGAGRAAG (p.Lys526Glu) ACCTTTCTGATCTGGTGTCAGA']

3829 NM_000313.3(PROSl):c.773A>G 5627 PROS1 ['AACATGTGTGCTCAGCTTTGTGTCARTTAC (p.Asn258Ser) CCTGGAGGTTACACTTGCTAT']

3830 NM_000313.3 (PROS 1 ) :c .586 A>G 5627 PROS1 ['AAATGGTTTTGTTATGCTTTCAAATRAGAA (p.Lysl96Glu) AGATTGTAAAGGTAAGAGCAG]

3831 NM_002834.3(PTPNl l):c.922A>G 5781 PTPN11 ['GCCTGTTTCAGATTACATCAATGCARATAT (p.Asn308Asp) CATCATGGTAAGCTTTGCTTT']

3832 NM_002834.3(PTPNl l):c.923A>G 5781 PTPN11 ['CCTGTTTCAGATTACATCAATGCAAVTATC (p.Asn308Ser) ATCATGGTAAGCTTTGCTTTT']

3833 NM_002834.3(PTPNl l):c.836A>G 5781 PTPN11 ['CAAGAAAACAAAAACAAAAATAGATVTA (p.Tyr279Cys) AAAACATCCTGCCCTGTAAGTAT']

3834 NM_002834.3(PTPNl l):c.l82A>G 5781 PTPN11 ['CACATCAAGATTCAGAACACTGGTGNTTA (p.Asp61Gly) CTATGACCTGTATGGAGGGGAG]

3835 NM_002834.3(PTPNl l):c.l88A>G 5781 PTPN11 ['AAGATTCAGAACACTGGTGATTACTRTGA (p.Tyr63Cys) CCTGTATGGAGGGGAGAAATTT']

3836 NM_002834.3(PTPNl l):c.227A>G 5781 PTPN11 ['GGGGAGAAATTTGCCACTTTGGCTGNGTT (p.Glu76Gly) GGTCCAGTATTACATGGAACAT']

3837 NM_002834.3(PTPNl l):c.236A>G 5781 PTPN11 ['TTTGCCACTTTGGCTGAGTTGGTCCRGTAT (p.Gln79Arg) TACATGGAACATCACGGGCAA]

3838 NM_002834.3(PTPNl l):c.l529A> 5781 PTPN11 ['TCAGGGATGGTCCAGACAGAAGCACVGTA G (p.Gln510Arg) CCGATTTATCTATATGGCGGTC]

3839 NM_002755.3(MAP2Kl):c.389A> 5604 MAP2K1 ['AACTCTCCGTACATCGTGGGCTTCTRTGGT G (p.Tyrl30Cys) GCGTTCTACAGCGATGGCGAG]

3840 NM_006006.4(ZBTB16):c. l849A> 7704 ZBTB16 ['CCAGCGCTCCCGGGACTACTCGGCCRTGAT G (p.Met617Val) CAAGCACCTGAGAACGCACAA]

3841 NM_000311.3(PRNP):c.385A>G 5621 PRNP ['AGTGGTGGGGGGCCTTGGCGGCTACRTGC (p.Metl29Val) TGGGAAGTGCCATGAGCAGGCC]

3842 NM_000311.3(PRNP):c.650A>G 5621 PRNP ['GTGGTTGAGCAGATGTGTATCACCCRGTAC (p.Gln217Arg) GAGAGGGAATCTCAGGCCTAT']

3843 NM_000311.3(PRNP):c.547A>G 5621 PRNP ['CTTTGTGCACGACTGCGTCAATATCRCAAT (p.Thrl83Ala) CAAGCAGCACACGGTCACCAC]

3844 NM_000311.3(PRNP):c.560A>G 5621 PRNP ['TGCGTCAATATCACAATCAAGCAGCRCAC (p.Hisl87Arg) GGTCACCACAACCACCAAGGGG]

3845 NM_000371.3 (TTR) : c.401 A>G 7276 TTR ['ACCATTGCCGCCCTGCTGAGCCCCTRCTCC (p.Tyrl34Cys) TATTCCACCACGGCTGTCGTC]

3846 NM_000371.3 (TTR) : c.238 A>G 7276 TTR ['GTCTGGAGAGCTGCATGGGCTCACARCTG (p.Thr80Ala) AGGAGGAATTTGTAGAAGGGAT']

3847 NM_000371.3(TTR):c. l85A>G 7276 TTR ['AGAAAGGCTGCTGATGACACCTGGGRGCC (p.Glu62Gly) ATTTGCCTCTGGGTAAGTTGCC]

3848 NM_000371.3(TTR):c.205A>G 7276 TTR ['CCAGACTTTCACACCTTATAGGAAARCCA (p.Thr69Ala) GTGAGTCTGGAGAGCTGCATGG]

3849 NM_000371.3 (TTR) : c.379 A>G 7276 TTR ['CGACTCCGGCCCCCGCCGCTACACCRTTGC (p.Ilel27Val) CGCCCTGCTGAGCCCCTACTC]

3850 NM_000371.3 (TTR) : c.113 A>G 7276 TTR ['TGTCCTCTGATGGTCAAAGTTCTAGRTGCT (p.Asp38Gly) GTCCGAGGCAGTCCTGCCATC]

3851 NM_000217.2(KCNAl):c.676A>G 3736 KCNA1 ['CACAGACCCCTTCTTCATCGTGGAARCGCT (p.Thr226Ala) GTGTATCATCTGGTTCTCCTT']

3852 NM_000217.2(KCNAl):c.763A>G 3736 KCNA1 ['GACGGACTTCTTCAAAAACATCATGRACTT (p.Asn255Asp) CATAGACATTGTGGCCATCAT']

3853 NM_002693.2(POLG):c.2864A>G 5428 POLG ['AAAATCTTCAACTACGGCCGCATCTRTGGT (p.Tyr955Cys) GCTGGGCAGCCCTTTGCTGAG]

3854 NM_002693.2(POLG):c.2591A>G 5428 POLG ['GAGCCCACATGGCTCACCGCCAGCARTGC (p.Asn864Ser) CCGGGTATGTGACCTCTGTACC]

3855 NM_000174.4(GP9):c.l82A>G 2815 GP9 ['ACCCGCCACCTTCTGCTGGCCAACARCAGC (p.Asn61Ser) CTTCAGTCCGTGCCCCCGGGA']

3856 NM_000174.4(GP9):c.l lOA>G 2815 GP9 ['CTGGAAACCATGGGGCTGTGGGTGGRCTG (p.Asp37Gly) CAGGGGCCACGGACTCACGGCC]

3857 NM_006206.4(PDGFRA):c.1664A 5156 PDGFRA ['CCTGGTCATTTATAGAAACCGAGGTRTGA >G (p.Tyr555Cys) AATTCGCTGGAGGGTCATTGAA']

3858 NM_000301.3(PLG):c. l l2A>G 5340 PLG ['GGGGGCTTCACTGTTCAGTGTCACTRAGAA (p.Lys38Glu) GCAGCTGGGAGCAGGAAGTAT']

3859 NM_000293.2(PHKB):c.306-2A>G 5257 PHKB ['GTTTCATGAGTTATCTCTCTCACCCRGGCG

AATTGATGATGACAAGGGAAG]

3860 NM_000175.3(GPI):c. l028A>G 2821 GPI ['ACACACGCCATGCTGCCCTATGACCRGTAC (p.Gln343Arg) CTGCACCGCTTTGCTGCGTAC]

3861 NM_002633.2(PGMl):c.343A>G 5236 PGM1 ['CAAAGCCATTGGTGGGATCATTCTGRCAG (p.Thrl l5Ala) CCAGTCACAACCCAGGGGGCCC]

3862 NM_006218.2(PIK3CA):c.3140A> 5290 PIK3CA ['TTCATGAAACAAATGAATGATGCACDTCA G (p.Hisl047Arg) TGGTGGCTGGACAACAAAAATG]

3863 NM_006218.2(PIK3CA):c.l634A> 5290 PIK3CA ['CGAGATCCTCTCTCTGAAATCACTGVGCAG G (p.Glu545Gly) GAGAAAGATTTTCTATGGAGT']

3864 NM_000478.4(ALPL):c.1250A>G 249 ALPL ['CCCTTCACTGCCATCCTGTATGGCARTGGG (p.Asn417Ser) CCTGGCTACAAGGTGGTGGGC]

3865 NM_018849.2(ABCB4):c.523A>G 5244 ABCB4 ['AGAAATAAACAGGTATAAGATGTGARTTC (p.Thrl75Ala) AGTCCTCAAATAAACCTACTAT',

3867 'TTCTATATGAAAGTGTGACATTAACRATGT

ACCTACTCTGTTAGCCGCGYA',

'TTTCCTGTCGTAGAATAGCATGAAARAACT

TCTGCCTAATTTTCCTGATCT']

3868 NM_001083116.1(PRFl):c.755A> 5551 PRF1 ['CTGGCCCTGGAAGGGCTCACGGACARCGA G (p.Asn252Ser) GGTGGAGGACTGCCTGACTGTC]

3869 NM_198965.1(PTHLH):c.534A>G 5744 PTHLH ['TTCCTTCTTTTTGCAGGAGGCATTGRAATT (p.Terl78Trp) TTCAGCAGAGACCTTCCAAGG]

3870 NM_000316.2(PTHlR):c.668A>G 5745 PTH1R ['CTGCACTGCACGCGCAACTACATCCRCATG (p.His223Arg) CACCTGTTCCTGTCCTTCATG]

3871 NM_003122.4(SPINKl):c.l01A>G 6690 SPINK1 ['TTCCATTTTTAGGCCAAATGTTACARTGAA (p.Asn34Ser) CTTAATGGATGCACCAAGATA]

3872 NM_006194.3(PAX9):c.271A>G 5083 PAX9 ['CGTGGTGAAACACATCCGGACCTACRAGC (p.Lys91Glu) AGAGAGACCCCGGCATCTTCGC]

3873 NM_013953.3 (P AX8) :c .160 A>G -1 ['CGACATCTCTCGCCAGCTCCGCGTCRGCCA (p.Ser54Gly) TGGCTGCGTCAGCAAGATCCT']

3874 NM_005188.3(CBL):c.l l44A>G 867 CBL ['GATGGGCTCCACATTCCAACTATGTRAAAT (p.Lys382Glu) ATGTGCTGAAAATGATAAGGA]

3875 NM_000222.2(KIT):c.2459A>G 3815 KIT ['GGTCTAGCCAGAGACATCAAGAATGRTTC (p.Asp820Gly) TAATTATGTGGTTAAAGGAAAC]

3876 NM_000222.2(KIT):c.2386A>G 3815 KIT ['GTGTATTCACAGAGACTTGGCAGCCRGAA (p.Arg796Gly) ATATCCTCCTTACTCATGGTCG]

3877 NM_000222.2(KIT):c.1924 A>G 3815 KIT ['ACGGGAAGCCCTCATGTCTGAACTCRAAG (p.Lys642Glu) TCCTGAGTTACCTTGGTAATCA']

3878 NM_001005862.2(ERBB2):c.2480 2064 ERBB2 ['CGGAACGTGCTGGTCAAGAGTCCCARCCA A>G (p.Asn827Ser) TGTCAAAATTACAGACTTCGGG]

3879 NM_001127500.1(MET):c.3743A> 4233 MET ['GATTTTGGTCTTGCCAGAGACATGTRTGAT G (p.Tyrl248Cys) AAAGAATACTATAGTGTACAC]

3880 NM_001127500.1(MET):c.3335A> 4233 MET ['ACAGGGCATTTTGGTTGTGTATATCVTGGG G (p.Hisl l l2Arg) ACTTTGTTGGACAATGATGGC]

3881 NM_001127500.1(MET):c.3785A> 4233 MET ['AGTGTACACAACAAAACAGGTGCAARGCT G (p.Lysl262Arg) GCCAGTGAAGTGGATGGCTTTG]

3882 NM_002524.4(NRAS):c.l82A>G 4893 NRAS ['TTGGACATACTGGATACAGCTGGACNAGA (p.Gln61Arg) AGAGTACAGTGCCATGAGAGAC]

3883 NM_004333.4(BRAF):c.l801A>G 673 BRAF ['AGGTGATTTTGGTCTAGCTACAGTGVAATC (p.Lys601Glu) TCGATGGAGTGGGTCCCATCA']

3884 NM_004333.4(BRAF):c.l781A>G 673 BRAF ['GAAGACCTCACAGTAAAAATAGGTGDTTT (p.Asp594Gly) TGGTCTAGCTACAGTGAAATCT']

3885 NM_004333.4(BRAF):c.770A>G 673 BRAF ['GACTTTTGTCGAAAGCTGCTTTTCCRGGGT (p.Gln257Arg) TTCCGCTGTCAAACATGTGGT']

3886 NM_004333.4(BRAF):c.l495A>G 673 BRAF ['TACACCTCAGCAGTTACAAGCCTTCRAAA (p.Lys499Glu) ATGAAGTAGGAGTACTCAGGTG]

3887 NM_004333.4(BRAF):c.l502A>G 673 BRAF ['CAGCAGTTACAAGCCTTCAAAAATGNAGT (p.Glu501Gly) AGGAGTACTCAGGTGAGCTTGT']

3888 NM_004333.4(BRAF):c.l741A>G 673 BRAF ['CATCCACAGAGACCTCAAGAGTAATVGTA (p.Asn581Asp) TCCTTCCTGAAATTTGTCTGCG]

3889 NM_000270.3 (PNP) :c .383 A>G 4860 PNP ['CTGAACCCCAAGTTTGAGGTTGGAGRTATC (p.Aspl28Gly) ATGCTGATCCGTGACCATATC]

3890 NM_000270.3(PNP):c.575A>G 4860 PNP ['CAACGTGAGCTACAGGAAGGCACCTRTGT (p.Tyrl92Cys) GATGGTGGCAGGCCCCAGCTTT']

3891 NM_000258.2(MYL3):c.445A>G 4634 MYL3 ['CGACAAGGAGGGCAATGGCACTGTCRTGG (p.Metl49Val) GTGCTGAGCTTCGCCACGTGCT']

3892 NM_000257.3(MYH7):c.2333A>G 4625 MYH7 ['CTGGGGCTGCTGGAGGAAATGAGGGRCGA (p.Asp778Gly) GAGGCTGAGCCGCATCATCACG]

3893 NM_000257.3(MYH7):c.2717A>G 4625 MYH7 ['CTGGCAGATGCTGAGGAGCGCTGTGRTCA (p.Asp906Gly) GCTGATCAAAAACAAGATTCAG]

3894 NM_002470.3(MYH3):c. l385A>G 4621 MYH3 ['AGACAACACTTCATTGGTGTTTTGGRCATT (p.Asp462Gly) GCAGGCTTTGAAATCTTTGAG]

3895 NM_000530.6(MPZ):c.286A>G 4359 MPZ ['CTACATTGACGAGGTGGGGACCTTCRAAG (p.Lys96Glu) AGCGCATCCAGTGGGTAGGGGA]

3896 NM_000530.6(MPZ):c.242A>G 4359 MPZ ['TCCCCTCATTCCTCATAGATCTTCCRCTAT (p.His81Arg) GCCAAGGGACAACCCTACATT']

3897 NG_012123.1 :g.2493A>G 6347 CCL2 ['GAAAAGAAAGTCTTCTGGAAAGTGAYAGC

TGTCTGCCTCCCACTTCTGCTC]

3898 RMRP:n.71A>G 6023 RMRP ['TGTTCCTCCCCTTTCCGCCTAGGGGRAAGT

CCCCGGACCTCGGGCAGAGAG]

3899 NM_005006.6(NDUFSl):c.755A> 4719 NDUFS1 ['TTTCTCAGAAAGACAGAATCCATTGRTGTA G (p.Asp252Gly) ATGGATGCGGTTGGAAGTAAT']

3900 NM_005912.2(MC4R):c.508A>G 4160 MC4R ['GACAGTTAAGCGGGTTGGGATCATCRTAA (p.Ilel70Val) GTTGTATCTGGGCAGCTTGCAC]

3901 NM_005912.2(MC4R):c.821A>G 4160 MC4R ['ATATTCTACATCTCTTGTCCTCAGARTCCA (p.Asn274Ser) TATTGTGTGTGCTTCATGTCT']

3902 NM_005912.2(MC4R):c.289A>G 4160 MC4R ['GGCTGATATGCTGGTGAGCGTTTCARATGG (p.Asn97Asp) ATCAGAAACCATTGTCATCAC]

3903 NM_005912.2(MC4R):c.l85A>G 4160 MC4R ['CTGGGTGTCATCAGCTTGTTGGAGARTATC (p.Asn62Ser) TTAGTGATTGTGGCAATAGCC]

3904 NM_000900.3(MGP):c.62-2A>G 4256 MGP ['AAGATTCCATGCTTTCATGTGATTCHGAAA

TTAAAAAAAAAAGATTCATTA]

3905 NM_012064.3 (MIP) :c .401 A>G 4284 MIP ['AGCGTGGGCCAGGCAACCACAGTGGRGAT (p.Glul34Gly) CTTCCTGACGCTCCAGTTCGTG]

3906 NM_000233.3(LHCGR):c. l733A> -1 ['AAAATGGCAATCCTCATCTTCACCGRTTTC G (p.Asp578Gly) ACCTGCATGGCACCTATCTCT']

3907 NM_000233.3(LHCGR):c. l691A> -1 ['CCAGAATTAATGGCTACCAATAAAGRTAC G (p.Asp564Gly) AAAGATTGCTAAGAAAATGGCA']

3908 NM_000894.2(LHB):c.221A>G 3972 LHB ['CAGGCGGTCCTGCCGCCCCTGCCTCRGGTG (p.Gln74Arg) GTGTGCACCTACCGTGATGTG]

3909 NM_000238.3(KCNH2):c.l408A> 3757 KCNH2 ['CATGTTCATTGTGGACATCCTCATCRACTT G (p.Asn470Asp) CCGCACCACCTACGTCAATGC]

3910 NM_001754.4(RUNXl):c.328A>G 861 RUNX1 ['GCTGCCTACGCACTGGCGCTGCAACRAGA (p.Lysl lOGlu) CCCTGCCCATCGCTTTCAAGGT']

3911 NM_170707.3(LMNA):c.608A>G 4000 LMNA ['AACAGGCTGCAGACCATGAAGGAGGDACT (p.Glu203Gly) GGACTTCCAGAAGAACATCTAC]

3912 NM_000421.3(KRT10):c. l315A>G -1 ['TGAATACCAACAACTCCTGGATATTDAGA (p.Lys439Glu) TCCGACTGGAGAATGAAATTCA']

3913 NM_000421.3(KRT10):c. l374- -1 ['CCGCCGCGTCCGCCGCCTCCGGAACYAAA 2A>G CGGGGTGAGGTCACATTCGGTT']

3914 NM_000422.2(KRT17):c.274A>G 3872 KRT17 ['TGAGAAGGCCACCATGCAGAACCTCVATG (p.Asn92Asp) ACCGCCTGGCCTCCTACCTGGA']

3915 NM_000422.2(KRT17):c.275A>G 3872 KRT17 ['GAGAAGGCCACCATGCAGAACCTCARTGA (p.Asn92Ser) CCGCCTGGCCTCCTACCTGGAC]

3916 NM_005557.3(KRT16):c.374A>G 3868 KRT16 ['GAGAAGGTGACCATGCAGAACCTCARTGA (p.Asnl25Ser) CCGCCTGGCCTCCTACCTGGAC]

3917 NM_000526.4(KRT14):c.368A>G 3861 KRT14 ['GAGAAGGTGACCATGCAGAACCTCARTGA (p.Asnl23Ser) CCGCCTGGCCTCCTACCTGGAC]

3918 NM_000424.3 (KRT5) :c .1424 A>G 3852 KRT5 ['ATCGCCACTTACCGCAAGCTGCTGGRGGG (p.Glu475Gly) CGAGGAATGCAGGTGAGTAGAC]

3919 NM_000418.3(IL4R):c.223A>G 3566 IL4R ['CTGTGTCTGCAGAGCCCACACGTGTNTCCC (p.Ile75Val) TGAGAACAACGGAGGCGCGGG]

3920 NM_001079817.1(INSR):c.l459A> 3643 INSR ['CCAGGAGAGAAACGACATTGCCCTGRAGA G (p.Lys487Glu) CCAATGGGGACCAGGCATCCTG]

3921 NM_000208.2(INSR):c.707A>G 3643 INSR ['TGCACCGCCGAAGGCCTCTGTTGCCRCAGC (p.His236Arg) GAGTGCCTGGGCAACTGTTCT']

3922 NM_000208.2(INSR):c.1466A>G 3643 INSR ['AGAAACGACATTGCCCTGAAGACCARTGG (p.Asn489Ser) GGACCAGGCATCCTGTAAGTCA']

3923 NM_000208.2(INSR):c. ll24-2A>G 3643 INSR ['CTTCTAGCTCAGCTGCCAGATTGTCYAAGG

AAAGGAGAGAATATCCAGTGG]

3924 NM_000208.2(INSR):c.1372A>G 3643 INSR ['TCAGGGGAAACTCTTCTTCCACTATRACCC (p.Asn458Asp) CAAACTCTGCTTGTCAGAAAT']

3925 M_000454.4(SODl):c.l31A>G 6647 SOD1 ['ATTAAAGGACTGACTGAAGGCCTGCRTGG (p.His44Arg) ATTCCATGTTCATGAGTTTGGA]

3926 M_000454.4(SODl):c.302A>G 6647 SOD1 ['GATGGTGTGGCCGATGTGTCTATTGRAGAT (p.GlulOlGly) TCTGTGATCTCACTCTCAGGA']

3927 M_000454.4(SODl):c.l40A>G 6647 SOD1 ['CTGACTGAAGGCCTGCATGGATTCCRTGTT (p.His47Arg) CATGAGTTTGGAGATAATACA]

3928 M_000454.4(SODl):c.242A>G 6647 SOD1 ['ATCTGATGCTTTTTCATTATTAGGCRTGTT (p.His81Arg) GGAGACTTGGGCAATGTGACT']

3929 NM_000183.2(HADHB):c.788A>G 3032 HADHB ['GCACAGGATGAAGGACTCCTTTCTGRTGTG (p.Asp263Gly) GTACCCTTCAAAGTACCAGGT']

3930 NM_000523.3(HOXD13):c.974A> 3239 HOXD13 ['GAGAGACAAGTGACCATTTGGTTTCRGAA G (p.Gln325Arg) CCGAAGAGTGAAGGACAAGAAA']

3931 NM_000545.6(HNFlA):c.365A>G 6927 HNF1A ['CGTGTGGCGAAGATGGTCAAGTCCTRCCT (p.Tyrl22Cys) GCAGCAGCACAACATCCCACAG]

3932 NM_000519.3(HBD):c.-81A>G 3045 HBD ['CTGGAGCAGGGAGGACAGGACCAGCRTAA

AAGGCAGGGCAGAGTCGACTGT']

3933 NM_000518.4(HBB):c.l99A>G 3043 HBB ['CCCTAAGGTGAAGGCTCATGGCAAGRAAG (p.Lys67Glu) TGCTCGGTGCCTTTAGTGATGG]

3934 NM_000518.4(HBB):c.59A>G 3043 HBB ['GTTACTGCCCTGTGGGGCAAGGTGARCGT (p.Asn20Ser) GGATGAAGTTGGTGGTGAGGCC]

3935 NM_000518.4(HBB):c.-81A>G 3043 HBB ['GGGAGGGCAGGAGCCAGGGCTGGGCVTA

AAAGTCAGGGCAGAGCCATCTAT']

3936 NM_000518.4(HBB):c.-50-29A>G 3043 HBB ['GAGGGCAGGAGCCAGGGCTGGGCATRAAA

GTCAGGGCAGAGCCATCTATTG]

3937 NM_000518.4(HBB):c.-78A>G 3043 HBB ['AGGGCAGGAGCCAGGGCTGGGCATAVAA

GTCAGGGCAGAGCCATCTATTGC]

3938 NM_000518.4(HBB):c.*113A>G 3043 HBB ['TGAGCATCTGGATTCTGCCTAATAARAAAC

ATTTATTTTCATTGCAATGAT']

3939 NM_000518.4(HBB):c.*112A>G 3043 HBB ['TTGAGCATCTGGATTCTGCCTAATADAAAA

CATTTATTTTCATTGCAATGA']

3940 NM_000518.4(HBB):c.*l l lA>G 3043 HBB ['CTTGAGCATCTGGATTCTGCCTAATRAAAA

ACATTTATTTTCATTGCAATG]

3941 NM_000518.4(HBB):c.80A>G 3043 HBB ['GTGAACGTGGATGAAGTTGGTGGTGNGGC (p.Glu27Gly) CCTGGGCAGGTTGGTATCAAGG]

3942 NM_000518.4(HBB):c.247A>G 3043 HBB ['TGGCCTGGCTCACCTGGACAACCTCVAGG (p.Lys83Glu) GCACCTTTGCCACACTGAGTGA]

3943 NM_000517.4(HBA2):c.lA>G 3040 HBA2 ['CCCACAGACTCAGAGAGAACCCACCRTGG (p.MetlVal) TGCTGTCTCCTGCCGACAAGAC]

3944 NM_000517.4(HBA2):c.*92A>G 3040 HBA2 ['CACCGGCCCTTCCTGGTCTTTGAATRAAGT

CTGAGTGGGCAGCAGCCTGTG]

3945 NM_000517.4(HBA2):c.96-2A>G 3040 HBA2 ['CACCCCTCACTCTGCTTCTCCCCGCRGGAT

GTTCCTGTCCTTCCCCACCAC]

3946 NM_006121.3(KRTl):c.l445A>G 3848 KRT1 ['GCCCTGGATCTGGAGATTGCCACCTRCAG (p.Tyr482Cys) GACCCTCCTGGAGGGAGAAGAA]

3947 NM_001077488.3(GNAS):c.lA>G 2778 GNAS ['GCGCCCCGCCGCCGCCGCCGCCGCCRTGG (p.MetlVal) GCTGCCTCGGGAACAGTAAGAC]

3948 NM_000516.5(GNAS):c.680A>G 2778 GNAS ['ACCAGCATGTTTGACGTGGGTGGCCDGCG (p.Gln227Arg) CGATGAACGCCGCAAGTGGATC]

3949 NM_000515.4(GHl):c.413A>G 2688 GH1 ['GGCGCCTCTGACAGCAACGTCTATGRCCTC (p.Aspl38Gly) CTAAAGGACCTAGAGGAAGGC]

3950 NM_000823.3(GHRHR):c.985A>G 2692 GHRHR ['TTGTCTTTCCTGCAGGCGTCTCTCCRAGTC (p.Lys329Glu) GACACTTTTCCTGATCCCACT']

3951 NM_002890.2(RASAl):c.1198A>G 5921 RASA1 ['GACCAATGAAAATATTCAGCGATTTRAAA (p.Lys400Glu) TATGTCCAACGCCAAACAATCA']

3952 NM_002890.2(RASAl):c.1201 A>G 5921 RASA1 ['CAATGAAAATATTCAGCGATTTAAARTAT (p.Ile401Val) GTCCAACGCCAAACAATCAGTT']

3953 NM_000406.2(GNRHR):c.317A>G 2798 GNRHR ['GATGGGATGTGGAACATTACAGTCCRATG (p.Glnl06Arg) GTATGCTGGAGAGTTACTCTGC]

3954 NM_000406.2(GNRHR):c.851A>G 2798 GNRHR ['TTTACTGTCTGCTGGACTCCCTACTRTGTC (p.Tyr284Cys) CTAGGAATTTGGTATTGGTTT']

3955 NM_000407.4(GPlBB):c.338A>G -1 ['GCCGGCCGCCCCGAGCGTGCGCCCTDCCG (p.Tyrl l3Cys) CGACCTGCGTTGCGTGGCGCCC]

3956 NM_021957.3(GYS2):c.l l6A>G 2998 GYS2 ['TTTGAAGTTGCTTGGGAAGTGACCARTAA (p.Asn39Ser) AGGTTTGTACTGCTCCTGAAGG]

3957 NM_001146040.1(GLRAl):c.920A 2741 GLRA1 ['CCTCCACCCCCACTCTAGGTGTCCTVTGTG >G (p.Tyr307Cys) AAAGCCATTGACATTTGGATG]

3958 NM_001146040.1(GLRAl):c.910A 2741 GLRA1 ['CTCCGGCTCTCGAGCATCTCTGCCCRAGGT >G (p.Lys304Glu) AAGTCCCATTGCCCAAGAGCA']

3959 NM_000171.3(GLRAl):c.523A>G 2741 GLRA1 ['CCCCATGGACTTGAAGAATTTCCCCRTGGA (p.Metl75Val) TGTCCAGACATGTATCATGCA']

3960 NM_000162.3(GCK):c.641A>G 2645 GCK ['ACGGTGGCCACGATGATCTCCTGCTRCTAC (p.Tyr214Cys) GAAGACCATCAGTGCGAGGTC]

3961 NM_000145.3(FSHR):c.l345A>G 2492 FSHR ['AGGCTGTGATGCTGCTGGCTTTTTCRCTGT (p.Thr449Ala) CTTTGCCAGTGAGCTGTCAGT']

3962 NM_182925.4(FLT4):c.3104A>G 2324 FLT4 ['CGCCTCCCCGCACCCCAGTGCATCCRCAGA (p.Hisl035Arg) GACCTGGCTGCTCGGAACATT']

3963 NM_023110.2(FGFRl):c.1121 A>G 2260 FGFR1 ['CCGGCAGTGATGACCTCGCCCCTGTRCCTG (p.Tyr374Cys) GAGATCATCATCTATTGCACA]

3964 NM_006894.5(FMO3):c.l82A>G 2328 FM03 ['AGCATTTACAAATCAGTCTTTTCCARCTCT (p.Asn61Ser) TCCAAAGAGATGATGTGTTTC]

3965 NM_001002294.2(FMO3):c.923A> 2328 FM03 ['AAGCCTAACGTGAAGGAATTCACAGRGAC G (p.Glu308Gly) CTCGGCCATTTTTGAGGATGGG]

3966 NM_212482.1(FNl):c.2918A>G 2335 FN1 ['ACCGGGCTGTCCCCTGGGGTCACCTRTTAC (p.Tyr973Cys) TTCAAAGTCTTTGCAGTGAGC]

3967 NM_000142.4(FGFR3):c. l948A>G 2261 FGFR3 ['CGTGCACAACCTCGACTACTACAAGVAGA (p.Lys650Glu) CAACCAACGTGAGCCCGGCCCT']

3968 NM_000142.4(FGFR3):c.1118A>G 2261 FGFR3 ['GAGGCTGACGAGGCGGGCAGTGTGTRTGC (p.Tyr373Cys) AGGCATCCTCAGCTACGGGGTG]

3969 NM_000142.4(FGFR3):c.1612A>G 2261 FGFR3 ['GTGCAGGCGCCCAGCAGGTTGATGAYGTT (p.Ile538Val) TTTGTGTTTCCCGATCATCTTC']

3970 NM_000142.4(FGFR3):c. l619A>G 2261 FGFR3 ['GCCCTGCGTGCAGGCGCCCAGCAGGBTGA (p.Asn540Ser) TGATGTTTTTGTGTTTCCCGAT']

3971 NM_000142.4(FGFR3):c.833A>G 2261 FGFR3 ['GACGTGGAGTTCCACTGCAAGGTGTRCAG (p.Tyr278Cys) TGACGCACAGCCCCACATCCAG]

3972 NM_000138.4(FBNl):c.6431A>G 2200 FBN1 ['GTCTGTAAACATGGACAGTGCATCARTAC (p.Asn2144Ser) AGATGGTTCCTATCGCTGCGAG]

3973 NM_000138.4(FBNl):c.3128A>G 2200 FBN1 ['ATACCCAGCCTCTGCACCCACGGCARGTG (p.Lysl043Arg) CAGAAACACCATTGGCAGCTTT']

3974 NM_000138.4(FBNl):c.2261A>G 2200 FBN1 ['TATAAATGTATATGCAATTCAGGATRTGAA (p.Tyr754Cys) GTGGATTCAACTGGGAAAAAC]

3975 NM_000146.3(FTL):c.-160A>G 2512 FTL ['CCGCGGGTCTGTCTCTTGCTTCAACRGTGT

TTGGACGGAACAGATCCGGGG]

3976 NM_000043.4(FAS):c.695A>G 355 FAS ['TTTTCAGATGTTGACTTGAGTAAATRTATC (p.Tyr232Cys) ACCACTATTGCTGGAGTCATG]

3977 NM_000043.4(FAS):c.763A>G 355 FAS ['AGGCTTTGTTCGAAAGAATGGTGTCRATG (p.Asn255Asp) AAGCCAAAATAGATGAGATCAA']

3978 NM_000043.4(FAS):c.353A>G 355 FAS ['TTTCTAGGCTTAGAAGTGGAAATAARCTGC (p.Asnl l8Ser) ACCCGGACCCAGAATACCAAG]

3979 NM_000129.3(F13Al):c.851A>G 2162 F13A1 ['CTCGTTGGATCCTGGGACAATATCTRTGCC (p.Tyr284Cys) TATGGCGTCCCCCCATCGGCC]

3980 NM_000121.3 (EPOR) :c .1460 A>G 2057 EPOR ['GGCTTATCCGATGGCCCCTACTCCARCCCT (p.Asn487Ser) TATGAGAACAGCCTTATCCCA]

3981 NM_207034.2(EDN3):c.335A>G 1908 EDN3 ['GACAAGGAGTGTGTCTACTATTGCCRCCTG (p.Hisll2Arg) GACATCATTTGGATCAACACT']

3982 NM_001257988.1(TYMP):c.665A> 1890 TYMP ['CAGAGCGGACAGCCCCTCCACGAGTYTCT G (p.Lys222Arg) TACTGAGAATGGAGGCTTTGGG]

3983 NM_003286.2(TOPl):c.l598A>G -1 ['GTAGAGTTTGACTTCCTCGGGAAGGRCTCC (p.Asp533Gly) ATCAGATACTATAACAAGGTC]

3984 NM_001943.3(DSG2):c.797A>G 1829 DSG2 ['GTTCAGATTCGTATTTTGGATGTCARTGAC (p.Asn266Ser) AATATACCTGTAGTAGAAAAT']

3985 NM_001943.3(DSG2):c. l880- 1829 DSG2 ['TCTGTGTTCAATTTTGTGTCTGTACRGTGG 2A>G TACCACTTTTACTGCTGATGT']

3986 NM_024422.4(DSC2):c.631-2A>G 1824 DSC2 ['TTTCTCCTTATTTTACTCTCTTCACRGATAA

TTGCCTTTGCAACAACTCCA']

3987 NG_012088.1 :g.2209A>G 3586 IL10 ['CCAGGATGGTCTCGATCTCCTGACCYTATG

ATCCGCCCGCCTTGGCCTCCC]

3988 NM_000498.3(CYPl lB2):c.l492A -1 ['GAGGCCTGGCACGTCCCCCCTCCTCRCTTT >G (p.Thr498Ala) CAGAGCGATTAACTAGTCTTG]

3989 NM_000941.2(POR):c.l733A>G 5447 POR ['CGCCGCTCGGATGAGGACTACCTGTRCCG (p.Tyr578Cys) GGAGGAGCTGGCGCAGTTCCAC]

3990 NM_000941.2(POR):c.l5A>G 5447 POR ['CTAACAGTTTCATGATCAACATGGGRGACT (p.Gly5=) CCCACGTGGACACCAGCTCCA]

3991 NM_001885.2(CRYAB):c.358A>G 1410 CRYAB ['TGGTTTCATCTCCAGGGAGTTCCACRGGAA (p.Argl20Gly) ATACCGGATCCCAGCTGATGT']

3992 NM_021954.3(GJA3):c.l88A>G 2700 GJA3 ['AACACCCAGCAGCCGGGCTGCGAGARCGT (p.Asn63Ser) CTGCTACGACAGGGCCTTCCCC]

3993 M_004004.5(GJB2):c.218A>G 2706 GJB2 ['TACGATCACTACTTCCCCATCTCCCRCATC (p.His73Arg) CGGCTATGGGCCCTGCAGCTG]

3994 NM_001735.2(C5):c.l l l5A>G 727 C5 ['CGTCTACCCCCTCACCCAATCTACCYTGAT (p.Lys372Arg) GGGATATGGAATCCCAGGCTT']

3995 NM_001848.2(COL6Al):c.362A> 1291 COL6A1 ['CTCAAAAGCAGCGTGGACGCGGTCARGTA G (p.Lysl21Arg) CTTTGGGAAGGGCACCTACACC]

3996 NM_000093.4(COL5Al):c.655- 1289 COL5A1 ['TTTTCATGAGCGTCTCTTCTTTTCCRGGGTG 2A>G ACATCCAGCAGCTGCTCTTT']

3997 NM_000089.3(COLlA2):c.226- 1278 COL1A2 ['TATAATTTTTTTTTTTTACTTCTCTRGAACT 2A>G TTGCTGCTCAGTATGATGGA']

3998 NM_000089.3(COLlA2):c.70+717 1278 COL1A2 ['GAGTGGGTACATTCTGAAAAGTAATRTAA A>G GTGTCTCAATTCACTTTCTAGT']

3999 M_001844.4(COL2Al):c.4172A> 1280 COL2A1 ['ACGGAAGGCTCCCAGAACATCACCTRCCA G (p.Tyrl391Cys) CTGCAAGAACAGCATTGCCTAT']

4000 M_001844.4(COL2Al):c.2974A> 1280 COL2A1 ['CGGTCTGCCTGGGCAACGTGGTGAGRGAG G (p.Arg992Gly) GATTCCCTGGCTTGCCTGGCCC]

4001 NM_000493.3(COL10Al):c. l790A -1 ['TTTACTTGTCAGATACCAGGAATATRCTAT >G (p.Tyr597Cys) TTTTCATACCACGTGCATGTG]

4002 NM_004385.4(VCAN):c.4004- 1462 VCAN ['GTATTGTGAAAACTCTGTTTTTTTCDGGTC 2A>G GAATGAGTGATTTGAGTGTAA']

4003 NM_020549.4(CHAT):c.1444 A>G 1103 CHAT ['CGTCAGCGAGCTCCCCGCCCCCCGGVGGC (p.Arg482Gly) TGCGGTGGAAATGCTCCCCGGA']

4004 NM_000078.2(CETP):c.l376A>G 1071 CETP ['AACAGCAAAGGCGTGAGCCTCTTCGRCAT (p.Asp459Gly) CATCAACCCTGAGATTATCACT']

4005 NM_000083.2(CLCNl):c.l655A>G 1180 CLCN1 ['GTGATTTGCTTCGAATTAACGGGTCDGATT (p.Gln552Arg) GCTCACATCCTGCCCATGATG]

4006 NM_000083.2(CLCNl):c.382A>G 1180 CLCN1 ['CTTTCTGGTGCTTCTGGGACTGCTGRTGGC (p.Metl28Val) TCTGGTCAGCTGGAGCATGGA']

4007 M_199440.1(HSPDl):c.86A>G 3329 HSPD1 ['CATCTCACTCGGGCTTATGCCAAAGRTGTA (p.Asp29Gly) AAATTTGGTGCAGATGCCCGA']

4008 NM_001904.3(CTNNBl):c.95A>G 1499 CTNNB1 ['CACTGGCAGCAACAGTCTTACCTGGNCTCT (p.Asp32Gly) GGAATCCATTCTGGTGCCACT']

4009 NM_001904.3(CTNNBl):c.l21A> 1499 CTNNB1 ['CTCTGGAATCCATTCTGGTGCCACTNCCAC G (p.Thr41Ala) AGCTCCTTCTCTGAGTGGTAA']

4010 NM_007294.3(BRCAl):c.211A>G 672 BRCA1 ['TTTATGTAAGAATGATATAACCAAARGGT (p.Arg71Gly) ATATAATTTGGTAATGATGCTA']

4011 NM_001202.3(BMP4):c.278A>G 652 BMP4 ['GATCTTTACCGGCTTCAGTCTGGGGRGGAG (p.Glu93Gly) GAGGAAGAGCAGATCCACAGC]

4012 NM_000342.3(SLC4Al):c.l66A>G 6521 SLC4A1 ['CACCACATCACACCCGGGTACCCACRAGG (p.Lys56Glu) TGAGGACCCCAGCCTCCTCCGT']

4013 NM_000342.3(SLC4Al):c.2509A> 6521 SLC4A1 ['GAAGACCTGGCGCATGCACTTATTCRCGG G (p.Thr837Ala) GCATCCAGATCATCTGCCTGGC]

4014 NM_001681.3(ATP2A2):c.2300A> 488 ATP2A2 ['TTCATCCGCTACCTCATCTCGTCCARCGTC G (p.Asn767Ser) GGGGAAGTTGTCTGGTAGGTC]

4015 NM_000486.5(AQP2):c.203A>G 359 AQP2 ['GGCCACATAAGCGGGGCCCACATCAVCCC (p.Asn68Ser) TGCCGTGACTGTGGCCTGCCTG]

4016 NM_000041.3(APOE):c.237-2A>G 348 APOE ['GACACCCTCCCGCCCTCTCGGCCGCRGGGC

GCTGATGGACGAGACCATGAA]

4017 NM_000041.3 (APOE) :c.490 A>G 348 APOE ['CGCCTCCCACCTGCGCAAGCTGCGTVAGC (p.Lysl64Glu) GGCTCCTCCGCGATGCCGATGA']

4018 NM_000041.3(APOE):c.l78A>G 348 APOE ['TTGGGATTACCTGCGCTGGGTGCAGRCACT (p.Thr60Ala) GTCTGAGCAGGTGCAGGAGGA']

4019 NM_000040.1(APOC3):c.280A>G 345 APOC3 ['GGATTTGGACCCTGAGGTCAGACCARCTTC (p.Thr94Ala) AGCCGTGGCTGCCTGAGACCT']

4020 NM_000040.1(APOC3):c.232A>G 345 APOC3 ['CCTGAAAGACTACTGGAGCACCGTTRAGG (p.Lys78Glu) ACAAGTTCTCTGAGTTCTGGGA']

4021 NM_001042425.1(TFAP2A):c.751 7020 TFAP2A ['GTCGCTGCTGGGCGGAGTGCTCCGGVGGT A>G (p.Arg251Gly) GAGGCCCGGCACGGCCCCGCCC]

4022 NM_000488.3(SERPINCl):c.655A 462 SERPINC1 ['TGCAGAGCAATCCAGAGCGGCCATCRACA >G (p.Asn219Asp) AATGGGTGTCCAATAAGACCGA']

4023 NM_001085.4(SERPINA3):c.l240 12 SERPINA3 ['TACAGACACCCAGAACATCTTCTTCRTGAG A>G (p.Met414Val) CAAAGTCACCAATCCCAAGCA]

4024 NM_001148.4(ANK2):c.4373A>G 287 ANK2 ['TGCATGGCATCTTGGGGCGGAAAGGRATC (p.Glul458Gly) AGAGTCAGATCAAGAACAGGAG]

4025 NM_001145.4(ANG):c. l21A>G -1 ['CTTCCTGACCCAGCACTATGATGCCRAACC (p.Lys41Glu) ACAGGGCCGGGATGACAGATA']

4026 NM_001145.4(ANG):c.208A>G -1 ['ACCCTGCAAAGACATCAACACATTTRTTCA (p.Ile70Val) TGGCAACAAGCGCAGCATCAA]

4027 M_000484.3(APP):c.2146A>G 351 APP ['GGGCGGTGTTGTCATAGCGACAGTGRTCG (p.Ile716Val) TCATCACCTTGGTGATGCTGAA']

4028 M_000484.3(APP):c.2078A>G 351 APP ['TTTGTTTTCAAGGTGTTCTTTGCAGRAGAT (p.Glu693Gly) GTGGGTTCAAACAAAGGTGCA]

4029 M_000484.3(APP):c.2140A>G 351 APP ['CATGGTGGGCGGTGTTGTCATAGCGRCAG (p.Thr714Ala) TGATCGTCATCACCTTGGTGAT']

4030 NM_000021.3(PSENl):c.488A>G 5663 PSEN1 ['AAATGCTTTCTTTTCTAGGTCATCCRTGCC (p.Hisl63Arg) TGGCTTATTATATCATCTCTA']

4031 NM_000021.3(PSENl):c.415A>G 5663 PSEN1 ['GCACTCAATTCTGAATGCTGCCATCRTGAT (p.Metl39Val) CAGTGTCATTGTTGTCATGAC]

4032 NM_000021.3(PSENl):c.436A>G 5663 PSEN1 ['CATCATGATCAGTGTCATTGTTGTCNTGAC (p.Metl46Val) TATCCTCCTGGTGGTTCTGTA']

4033 NM_000021.3(PSENl):c.839A>G 5663 PSEN1 ['GTTGAAACAGCTCAGGAGAGAAATGVAAC

GCTTTTTCCAGCTCTCATTTAC]

(p.Glu280Gly)

4034 NM_000021.3(PSENl):c.998A>G 5663 PSEN1 ['CAAGACACTGTTGCAGAGAATGATGRTGG (p.Asp333Gly) CGGGTTCAGTGAGGAATGGGAA]

4035 NM_000034.3 (ALDO A) : c.386 A>G 226 ALDOA ['CCCCTTCCTCTTCTCTTAGGGTTGGRTGGG (p.Aspl29Gly) CTGTCTGAGCGCTGTGCCCAG]

4036 NM_000477.5(ALB):c.714-2A>G 213 ALB ['CATTTTGATTGGCGATTTTCTTTTTDGGGC

AGTAGCTCGCCTGAGCCAGAG]

4037 NM_001151.3(SLC25A4):c.311A> 291 SLC25A4 ['AAGCAGCTCTTCTTAGGGGGTGTGGRTCG G (p.Aspl04Gly) GCATAAGCAGTTCTGGCGCTAC]

4038 NM_013411.4(AK2):c.lA>G 204 AK2 ['GTGGCAGTGAGAGACTTCGGCGGACRTGG (p.MetlVal) CTCCCAGCGTGCCAGCGGCAGA']

4039 NM_013411.4(AK2):c.494A>G 204 AK2 ['AACCCTCCAAAAGAGCCCATGAAAGRTGA (p.Aspl65Gly) CGTATGTAAACTCAGGACAAAA]

4040 NM_000476.2(AKl):c.491A>G 203 AK1 ['GCCACAGAACCCGTCATCGCCTTCTRTGAG (p.Tyrl64Cys) AAACGTGGCATTGTGCGCAAG]

4041 NM_001100.3(ACTAl):c.350A>G 58 ACTA1 ['GAGGCCCCCCTCAATCCCAAGGCCARCCG (p.Asnl l7Ser) CGAGAAGATGACCCAGATCATG]

4042 NM_001103.3(ACTN2):c.26A>G 88 ACTN2 ['ATGAACCAGATAGAGCCCGGCGTGCRGTA (p.Gln9Arg) CAACTACGTGTACGACGAGGAT']

4043 NM_005159.4(ACTCl):c. l088A>G -1 ['CAGCAAATGTGGATTAGCAAGCAAGRGTA (p.Glu363Gly) CGATGAGGCAGGCCCATCCATT']

4044 NM_005159.4(ACTCl):c.373A>G -1 ['CAACCGGGAGAAGATGACTCAGATCRTGT (p.Metl25Val) TTGAGACCTTCAATGTCCCTGC]

4045 NM_018109.3(MTPAP):c.l432A> 55149 MTPAP ['TGATTCTTCTCCTCTGTACATTCAGRATCC G (p.Asn478Asp) ATTTGAAACTTCTCTCAACAT']

4046 NM_016955.3(SEPSECS):c.l001A 51091 SEPSECS ['TTATTGTCACTTGGATCAAATGGCTRTAAG >G (p.Tyr334Cys) AAGCTACTAAAAGAAAGAAAG]

4047 NM_014053.3(FLVCRl):c.361A> 28982 FLVCR1 ['GATCTTCAGCCTGTACTCGCTGGTCRACGC G (p.Asnl21Asp) CTTTCAGTGGATCCAGTACAG]

4048 NM_000021.3(PSENl):c.697A>G 5663 PSEN1 ['ATATCTCATTATGATTAGTGCCCTCDTGGC (p.Met233Val) CCTGGTGTTTATCAAGTACCT']

4049 NM_000207.2(INS):c.323A>G -1 ['TGCTCCCTCTACCAGCTGGAGAACTRCTGC (p.Tyrl08Cys) AACTAGACGCAGCCCGCAGGC]

4050 NM_000334.4(SCN4A):c.4078A>G 6329 SCN4A ['GAAGCAGGCCTTCGACATCACCATCRTGA (p.Metl360Val) TCCTCATCTGCCTCAACATGGT']

4051 NM_000334.4(SCN4A):c.4108A>G 6329 SCN4A ['CCTCATCTGCCTCAACATGGTCACCRTGAT (p.Metl370Val) GGTGGAGACAGACAACCAGAG]

4052 NM_000518.4(HBB):c.316-2A>G 3043 HBB ['TTCATACCTCTTATCTTCCTCCCACVGCTCC

TGGGCAACGTGCTGGTCTGT']

4053 NM_000525.3(KCNJl l):c. l55A>G 3767 KCNJ11 ['GTGGCCCACAAGAACATCCGGGAGCRGGG (p.Gln52Arg) CCGCTTCCTGCAGGACGTGTTC]

4054 NM_000525.3(KCNJl l):c.544A>G 3767 KCNJ11 ['AGCCCACCGCAGGGCTGAGACCCTCRTCTT (p.Ilel82Val) CAGCAAGCATGCGGTGATCGC]

4055 NM_000525.3(KCNJl l):c.886A>G 3767 KCNJ11 ['GGAAGGCGTGGTGGAAACCACGGGCVTCA (p.Ile296Val) CCACCCAGGCCCGCACCTCCTA]

4056 NM_000525.3(KCNJl l):c.989A>G 3767 KCNJ11 ['GAGGACGGACGTTACTCTGTGGACTRCTCC (p.Tyr330Cys) AAGTTTGGCAACACCGTCAAA]

4057 NM_000528.3(MAN2Bl):c.l831- 4125 MAN2B1 ['CCCATCTGTGGACCCTTTTCTGCCCRGCAC 2A>G ATCCGGGCAACGTTTGATCCT']

4058 NM_000639.2(FASLG):c.466A>G 356 FASLG ['ATTTATTTCAGGCAAGTCCAACTCARGGTC (p.Argl56Gly) CATGCCTCTGGAATGGGAAGA']

4059 NM_000920.3(PC):c.l705A>G 5091 PC ['CCCGGGGCTGCTGCTGATGGACACGRCCTT (p.Thr569Ala) CAGGGACGCCCACCAGTCACT']

4060 NM_001017420.2(ESCO2):c.l l32- 15757 ESC02 ['AATGGGTTTCTTTTTTTACCCCCCARTTATA 7A>G 0 GGACGCTGGTCAGAAACATT']

4061 NM_001017420.2(ESCO2):c.l674- 15757 ESC02 ['ATTAAATCATCTTTTCTTCTCTTTTRGGAAT 2A>G 0 TGCTTCATGTTTGGCTGTTT']

4062 NM_001129765.1(NSDHL):c.l046 50814 NSDHL ['GAGAGAGCCAAAAAGGCCATGGGCTVCCA A>G (p.Tyr349Cys) GCCACTAGTGACCATGGATGAT']

4063 NM_001701.3(BAAT):c.967A>G 570 BAAT ['AGAGGCCCAGGGGCAATTCCTCTTCRTTGT (p.Ile323Val) AGGAGAAGGTGATAAGACTAT']

4064 NM_002977.3(SCN9A):c.406A>G 6335 SCN9A ['ATTCAGCATGCTCATCATGTGCACTRTTCT (p.Ilel36Val) GACAAACTGCATATTTATGAC]

4065 M_004004.5(GJB2):c.487A>G 2706 GJB2 ['CTATGTCATGTACGACGGCTTCTCCRTGCA (p.Metl63Val) GCGGCTGGTGAAGTGCAACGC]

4066 NM_004519.3 (KCNQ3 ) :c .1403 A> 3786 KCNQ3 ['GAACCAAAGCCTGTTGGCTTAAACARTAA G (p.Asn468Ser) AGAGCGTTTCCGCACGGCCTTC]

4067 NM_004519.3 (KCNQ3 ) :c .2462 A> 3786 KCNQ3 ['AGAGATGATTATGTGTTCGGCCCCARTGG G (p.Asn821Ser) GGGGTCGAGCTGGATGAGGGAG]

4068 NM_004519.3 (KCNQ3 ) :c .914 A>G 3786 KCNQ3 ['AAAGAGGAGTTTGAGACCTATGCAGRTGC (p.Asp305Gly) CCTGTGGTGGGGCCTGGTGAGT']

4069 NM_004525.2(LRP2):c.770-2A>G 4036 LRP2 ['TGTAACTCTCTCTTTTTCCCCCCACRGAAA

GCGGTCCTCATGATGTTCATA']

4070 NM_007375.3(TARDBP):c.l055A 23435 TARDBP ['CAGAACCAGTCAGGCCCATCGGGTARTAA >G (p.Asn352Ser) CCAAAACCAAGGCAACATGCAG]

4071 NM_007375.3 (TARDBP) :c .800 A> 23435 TARDBP ['AATGCCGAACCTAAGCACAATAGCARTAG G (p.Asn267Ser) ACAGTTAGAAAGAAGTGGAAGA]

4072 NM_012434.4(SLC17A5):c.406A> 26503 SLC17A5 ['ATATGTTGCCAGCAAAATAGGGGGGDAAA G (p.Lysl36Glu) TGCTGCTAGGATTTGGGATCCT']

4073 NM_012463.3(ATP6V0A2):c.732- 23545 ATP6V0A ['AGACTGTGTTCAACTCTTGTCTTCCRGCTA 2A>G 2 CCACTGCCACGTGTACCCCTA']

4074 M_014043.3(CHMP2B):c.85A>G 25978 CHMP2B ['GTTACGAGGTACACAGAGGGCTATARTCA (p.Ile29Val) GAGATCGAGCAGCTTTAGAGAA']

4075 NM_018136.4(ASPM):c.2761- 25926 ASPM ['AGCAAAATTATAATATTGGAATATARTATC 25A>G 6 TGGAACTTATTTCTTTATAGG]

4076 NM_022081.5(HPS4):c.461A>G 89781 HPS4 ['ATTCTGAAAAACACCAGTGATCTGCRTAA

GATTTTCAATTCCCTCTGGAAC]

(p.Hisl54Arg)

4077 NM_024649.4(BBSl):c.l340- -1 ['GTCAGCCTCTGGGACCCTTCTCCACRGCCA 2A>G TGCACCGGGCCTTCCAGACAG]

4078 NM_032520.4(GNPTG):c.610- 84572 GNPTG ['TGCTGCCCCTGCATCCTCCACCTTCRGGGC 2A>G CATGAGAAGTTGCTGAGGACA]

4079 NM_172107.2(KCNQ2):c.lA>G 3785 KCNQ2 ['CCCGGGGCGCCTCCCGCCAGGCACCRTGG (p.MetlVal) TGCAGAAGTCGCGCAACGGCGG]

4080 NM_172107.2(KCNQ2):c.356A>G 3785 KCNQ2 ['GTGTTTTCCACCATCAAGGAGTATGRGAA (p.Glul l9Gly) GAGCTCGGAGGGGGCCCTCTAC]

4081 NM_172107.2(KCNQ2):c.622A>G 3785 KCNQ2 ['CCTGCGCTTCCTGCAGATTCTGCGGRTGAT (p.Met208Val) CCGCATGGACCGGCGGGGAGG]

4082 NM_172107.2(KCNQ2):c.635A>G 3785 KCNQ2 ['CAGATTCTGCGGATGATCCGCATGGRCCG (p.Asp212Gly) GCGGGGAGGCACCTGGAAGCTG]

4083 NM_172107.2(KCNQ2):c.773A>G 3785 KCNQ2 ['GTGTACTTGGCAGAGAAGGGGGAGARCGA (p.Asn258Ser) CCACTTTGACACCTACGCGGAT']

4084 NM_172107.2(KCNQ2):c.l764- 3785 KCNQ2 ['ATGCTTTGGGGTCTCTGTTCCCGGTRGAGT 2A>G GGACCAGATCGTGGGGCGGGG]

4085 NM_000495.4(COL4A5):c. lA>G 1287 COL4A5 ['AAGGAGCTGCGGGAGCCGGAGAAGARTG (p.MetlVal) AAACTGCGTGGAGTCAGCCTGGC]

4086 NM_000495.4(COL4A5):c.466- 1287 COL4A5 ['AGAACTTCCATTGATGGCTTCTTTTRGGGT 2A>G GAACCAGGTAGTATAATTATG]

4087 NM_000495.4(COL4A5):c.547- 1287 COL4A5 ['TCATTTTCTTTACTCACTTTATAACRGGGC 2A>G CTACCTGGTCCCACTGGTATA']

4088 NM_000495.4(COL4A5):c.610- 1287 COL4A5 ['ATTTTCTCTTTTGTCTTCTCTTCTTRGGGCC 2A>G CTCCTGGTCCACCAGGACTT']

4089 NM_000495.4(COL4A5):c.892- 1287 COL4A5 ['GCCCTATCATTTCTTTGTATCCTATRGGGT 2A>G AAACCAGGCAAAGATGGAGAA']

4090 NM_000495.4(COL4A5):c. l340- 1287 COL4A5 ['TTGCTATCCTTTCTTTATCTTACTCRGGTGA 2A>G TGAGATATGTGAACCAGGCC]

4091 NM_000495.4(COL4A5):c.2042- 1287 COL4A5 ['TTCTTTGAACGTTTTCCTTTCAATARCTGCT 18A>G GTTTCTCCATAGGTGACCCT']

4092 NM_000495.4(COL4A5):c.2147- 1287 COL4A5 ['GTTAAAAAATGACTTATCATTTTACRGGCT 2A>G TTCCTGGAATTCCAGGACCTC]

4093 NM_000495.4(COL4A5):c.2394A> 1287 COL4A5 ['GCTTAGATGGGCTCCCTGGACCAAARGGT G (p.Lys798=) ATGGAGGCTGTCACTGCATCTC]

4094 NM_000495.4(COL4A5):c.2510- 1287 COL4A5 ['CAGATACATCTTTTAAAACTGCTTCRGTAC 33A>G TTATTAATATTGATATTGTAT']

4095 NM_000495.4(COL4A5):c.2692A> 1287 COL4A5 ['ATTCTTCAAAGGTACCAAAGGTGAARTGG G (p.Met898Val) GTATGATGGGACCTCCAGGCCC]

4096 NM_000495.4(COL4A5):c.2746A> 1287 COL4A5 ['AGGACCTTTGGGAATTCCTGGCAGGRGTG G (p.Ser916Gly) GTGTACCTGGTCTTAAAGGTAA']

4097 NM_000495.4(COL4A5):c.3107- 1287 COL4A5 ['ATATTATATATCACATATTTTCAACRGGGC 2A>G CTCAGGGTGTGGAAGGGCCTC]

4098 NM_000495.4(COL4A5):c.3455- 1287 COL4A5 ['AACTGGGTGTAACCTGCTGTACTCARTTTT 9A>G TTAGGTGGTGGAGGTCATCCT']

4099 NM_000495.4(COL4A5):c.3605- 1287 COL4A5 ['TCTTCTAATTATACTTTACTTTCATRGGCCA 2A>G AAAGGGTGATGGAGGATTAC]

4100 NM_000495.4(COL4A5):c.3925- 1287 COL4A5 ['GTAACATTAATGATTTTATTTATTCRGGGT 2A>G AATCCTGGCCGGCCGGGTCTC]

4101 NM_000495.4(COL4A5):c.3998- 1287 COL4A5 ['ATAAAACTGTATGTACCTTCTGTGCDGGCA 2A>G TGAAAGGACCCAGTGGAGTAC]

4102 NM_000495.4(COL4A5):c.4790A> 1287 COL4A5 ['GGATGGGATTCTCTGTGGATTGGTTRTTCC G (p.Tyrl597Cys) TTCATGATGGTATTTTACACT']

4103 NM_000495.4(COL4A5):c.4977- 1287 COL4A5 ['CTGATTGTCTTATTTCTTATTTCCCRGTAAA 2A>G CCTCAGTCAGAAACGCTGAA']

4104 NM_005359.5(SMAD4):c.425- 4089 SMAD4 ['TTTCATTTGTTTTCCCCTTTAAACARTTAAG 6A>G ATCTCTCAGGATTAACACTG']

4105 NM_005359.5(SMAD4):c.989A>G 4089 SMAD4 ['TATTGGTGTTCCATTGCTTACTTTGRAATG (p.Glu330Gly) GATGTTCAGGTAGGAGAGACA']

4106 NM_020630.4(RET):c. l996A>G 5979 RET ['CCACTGCTACCACAAGTTTGCCCACVAGCC (p.Lys666Glu) ACCCATCTCCTCAGCTGAGAT']

4107 NM_020630.4(RET):c.2342A>G 5979 RET ['CTGTCAGAGTTCAACGTCCTGAAGCRGGTC (p.Gln781Arg) AACCACCCACATGTCATCAAA']

4108 NM_000060.3(BTD):c.l94A>G 686 BTD ['TATTATGTGGCTGCCGTGTATGAGCRTCCA (p.His65Arg) TCCATCCTGAGTCTGAACCCT']

4109 NM_000060.3(BTD):c.278A>G 686 BTD ['CTCATGAACCAGAACCTTGACATCTRTGAA (p.Tyr93Cys) CAGCAAGTGATGACTGCAGCC]

4110 NM_000060.3(BTD):c.356A>G 686 BTD ['CCAGAAGATGGCATTCATGGATTCARCTTT (p.Asnl l9Ser) ACAAGAACATCCATTTATCCA']

4111 NM_000060.3(BTD):c.364A>G 686 BTD ['TGGCATTCATGGATTCAACTTTACARGAAC (p.Argl22Gly) ATCCATTTATCCATTTTTGGA]

4112 NM_000060.3(BTD):c.515A>G 686 BTD ['AGGGGAGATATGTTCTTGGTGGCCARTCTT (p.Asnl72Ser) GGGACAAAGGAGCCTTGTCAT']

4113 NM_000060.3(BTD):c.583A>G 686 BTD ['CCCAAAAGATGGGAGATACCAGTTCRACA (p.Asnl95Asp) CAAATGTCGTGTTCAGCAATAA']

4114 NM_000060.3(BTD):c.584A>G 686 BTD ['CCAAAAGATGGGAGATACCAGTTCARCAC (p.Asnl95Ser) AAATGTCGTGTTCAGCAATAAT']

4115 NM_000060.3(BTD):c.641A>G 686 BTD ['CTTGTTGACCGCTACCGTAAACACARCCTC (p.Asn214Ser) TACTTTGAGGCAGCATTCGAT']

4116 NM_000060.3(BTD):c.880A>G 686 BTD ['GAAAGCTTTTGCTGTTGCCTTTGGCRTCAA (p.Ile294Val) CGTTCTGGCAGCTAATGTCCA]

4117 NM_000060.3(BTD):c.l205A>G 686 BTD ['TTTCACTCTGAGATGATGTATGACARTTTC (p.Asn402Ser) ACCCTGGTCCCTGTCTGGGGA']

4118 NM_000060.3(BTD):c.l313A>G 686 BTD ['AGGCCCACCTTATCCAAAGAGCTGTRTGCC (p.Tyr438Cys) CTGGGGGTCTTTGATGGGCTT']

4119 NM_000060.3(BTD):c.l619A>G 686 BTD ['ACGGCGGCTCTCTATGGGCGCTTGTRTGAG (p.Tyr540Cys) AGGGACTAGGAAAAGTGTGTG]

4120 NM_000155.3 (GALT) : c.1 A>G 2592 GALT ['TTCCAGCGGATCCCCCGGTGGCCTCRTGTC (p.MetlVal) GCGCAGTGGAACCGATCCTCA']

4121 NM_000155.3(GALT):c.67A>G 2592 GALT ['GTCAGAGGCGGACGCCGCAGCAGCARCCT (p.Thr23Ala) TCCGGGCAAACGGTAACTGCAC]

4122 NM_000155.3(GALT):c.253-2A>G 2592 GALT ['GTGCTTCTAGCCTATCCTTGTCGGTRGGTG AATCCCCAGTACGATAGCACC]

4123 NM_000155.3(GALT):c.290A>G 2592 GALT ['TACGATAGCACCTTCCTGTTTGACARCGAC (p.Asn97Ser) TTCCCAGCTCTGCAGCCTGAT']

4124 NM_000155.3(GALT):c.308A>G 2592 GALT ['TTTGACAACGACTTCCCAGCTCTGCRGCCT (p.Glnl03Arg) GATGCCCCCAGTCCAGGTAAC]

4125 NM_000155.3(GALT):c.379A>G 2592 GALT ['ATCTTTTCTCCCGTCACCACCCAGTRAGGT (p.Lysl27Glu) CATGTGCTTCCACCCCTGGTC]

4126 NM_000155.3(GALT):c.424A>G 2592 GALT ['CTGGTCGGATGTAACGCTGCCACTCRTGTC (p.Metl42Val) GGTCCCTGAGATCCGGGCTGT']

4127 NM_000155.3(GALT):c.565-2A>G 2592 GALT ['TTCTTCTCTGCTTTTGCCCCTTGACRGGTAT

GGGCCAGCAGTTTCCTGCCA']

4128 NM_000155.3(GALT):c.574A>G 2592 GALT ['TTTTGCCCCTTGACAGGTATGGGCCRGCAG (p.Serl92Gly) TTTCCTGCCAGATATTGCCCA']

4129 NM_000155.3(GALT):c.626A>G 2592 GALT ['CGTGAGGAGCGATCTCAGCAGGCCTVTAA (p.Tyr209Cys) GAGTCAGCATGGAGAGCCCCTG]

4130 NM_000155.3(GALT):c.752A>G 2592 GALT ['GTCCCCTTCTGGGCAACATGGCCCTVCCAG (p.Tyr251Cys) ACACTGCTGCTGCCCGTCGGC]

4131 NM_000155.3 (GALT) : c.812 A>G 2592 GALT ['CGGCTACCTGAGCTGACCCCTGCTGRGCGT (p.Glu271Gly) GATGGTCAGTCTCCCAAGTAG]

4132 NM_000155.3(GALT):c.821-2A>G 2592 GALT ['AGGCTGAGAGTCAGGCTCTGATTCCRGAT

CTAGCCTCCATCATGAAGAAGC]

4133 NM_000155.3(GALT):c.854A>G 2592 GALT ['TCCATCATGAAGAAGCTCTTGACCARGTAT (p.Lys285Arg) GACAACCTCTTTGAGACGTCC]

4134 NM_000155.3(GALT):c.968A>G 2592 GALT ['CATTGGCAGCTGCACGCTCATTACTRCCCT (p.Tyr323Cys) CCGCTCCTGCGCTCTGCCACT']

4135 NM_000155.3(GALT):c. l001A>G 2592 GALT ['CTCCTGCGCTCTGCCACTGTCCGGARATTC (p.Lys334Arg) ATGGTTGGCTACGAAATGCTT']

4136 NM_000155.3(GALT):c. l048A>G 2592 GALT ['GCTTGCTCAGGCTCAGAGGGACCTCRCCCC (p.Thr350Ala) TGAGCAGGTCAGGACTCAGAA']

4137 NM_000155.3(GALT):c. l l32A>G 2592 GALT ['GCAGAAGGACAGGGAGACAGCAACCRTCG (p.Ile378Val) CCTGACCACGCCGACCACAGGG]

4138 NM_000553.4(WRN):c.403A>G 7486 WRN ['GTTGCTTGAAAATAAAGCAGTTAAARAGG (p.Lysl35Glu) CAGGTGTAGGAATTGAAGGAGA']

4139 NM_000433.3(NCF2):c.481A>G 4688 NCF2 ['CTTACCCAGACACACTCCATCGCCTYGTCG (p.Lysl61Glu) ATTTTGGAATGTCTGGGCTCA]

4140 NM_198056.2(SCN5A):c. l673A>G 6331 SCN5A ['ACAGCGGGGGAGAGCGAGAGCCACCRCAC (p.His558Arg) ATCACTGCTGGTGCCCTGGCCC]

4141 NM_000074.2(CD40LG):c.386A> 959 CD40LG ['CAAATTGCGGCACATGTCATAAGTGRGGC G (p.Glul29Gly) CAGCAGTAAAACAACATCTGGT']

4142 NM_002863.4(PYGL):c. l016A>G 5836 PYGL ['CCCACCCAGGTGGCCATCCAGCTGARTGA (p.Asn339Ser) CACTCACCCTGCACTCGCGATC]

4143 NM_000142.4(FGFR3):c.1454A>G 2261 FGFR3 ['CCCCTTGGGGAGGGCTGCTTCGGCCRGGT (p.Gln485Arg) GGTCATGGCGGAGGCCATCGGC]

4144 NM_001101.3(ACTB):c.34A>G 60 ACTB ['TGATATCGCCGCGCTCGTCGTCGACVACG (p.Asnl2Asp) GCTCCGGCATGTGCAAGGCCGG]

4145 NM_001202.3(BMP4):c.362A>G 652 BMP4 ['TGGGGGAAGAGACTGACCTTCGTGGYGGA (p.Hisl21Arg) AGCTCCTCACGGTGTTGGCCCG]

4146 NM_000094.3(COL7Al):c.425A> 1294 COL7A1 ['CAGCTGGCCCGACCTGGTGTCCCCARGGT G (p.Lysl42Arg) GATCCCTACCCCTACCATGCCT']

NM_001130823.1(DNMTl):c. l532 1786 DNMT1 []

A>G (p.Tyr511Cys)

4147 NM_000138.4(FBNl):c.5096A>G 2200 FBN1 ['AGAAGAAGTTTGTGCTACAGAAACTRCTA (p.Tyrl699Cys) TGCTGACAACCAGACCTGTGAT']

4148 NM_000138.4(FBNl):c.5087A>G 2200 FBN1 ['CTAGATATGAGAAGAAGTTTGTGCTRCAG (p.Tyrl696Cys) AAACTACTATGCTGACAACCAG]

4149 NM_000138.4(FBNl):c.5099A>G 2200 FBN1 ['AGAAGTTTGTGCTACAGAAACTACTRTGCT (p.Tyrl700Cys) GACAACCAGACCTGTGATGGA]

4150 NM_001244710.1(GFPTl):c.43A> 2673 GFPT1 ['TTACTTAAACTACCATGTTCCTCGARCGAG G (p.Thrl5Ala) ACGAGAAATCCTGGAGACCCT']

4151 NM_002292.3(LAMB2):c.440A>G 3913 LAMB2 ['CTGGAGGCTGAGTTTCATTTCACACRCCTC (p.Hisl47Arg) ATTATGACCTTCAAGGTGCCT']

4152 NM_005211.3(CSFlR):c. l754- 1436 CSF1R ['GACTTAAGGGACCTGTGTGCGTGGCRGGT 2A>G AAGACCCTCGGAGCTGGAGCCT']

4153 NM_005247.2(FGF3):c.146A>G 2248 FGF3 ['GGGGCGCCCCGGCGCCGCAAGCTCTRCTG (p.Tyr49Cys) CGCCACGAAGTACCACCTCCAG]

4154 NM_005247.2(FGF3):c.317A>G 2248 FGF3 ['GCCATGAACAAGAGGGGACGACTCTRTGC (p.Tyrl06Cys) TTCGGTGAGTCCAGGCTGTCAC]

4155 NM_005188.3(CBL):c.l l l2A>G 867 CBL ['TAATCAAAGGAACAATATGAATTATRCTG (p.Tyr371Cys) TGAGATGGGCTCCACATTCCAA']

4156 NM_000313.3(PROSl):c.701A>G 5627 PROS1 ['TGTGAATGCCCCGAAGGCTACAGATRTAA (p.Tyr234Cys) TCTCAAATCAAAGTCTTGTGAA']

4157 NM_000329.2(RPE65):c.1292A>G 6121 RPE65 ['TACCAGAAGTATTGTGGGAAACCTTRCAC (p.Tyr431Cys) ATATGCGTATGGACTTGGCTTG]

4158 NM_001040142.1(SCN2A):c.4419 6326 SCN2A ['TGAATCTTTTCATTGGTGTCATCATRGATA A>G (p.Ilel473Met) ACTTCAACCAACAGAAAAAGA']

4159 NM_001040142.1(SCN2A):c.754A 6326 SCN2A ['GTCAGTGAAGAAGCTTTCTGATGTCRTGAT >G (p.Met252Val) CTTGACTGTGTTCTGTCTAAG]

4160 NM_004612.3(TGFBRl):c. l34A> 7046 TGFBR1 ['TTCTGCCACCTCTGTACAAAAGACARTTTT G (p.Asn45Ser) ACTTGTGTGACAGATGGGCTC]

4161 NM_003688.3(CASK):c.2168A>G 8573 CASK ['TTTGATCAATTAGATCTTGTCACATRTGAA (p.Tyr723Cys) GAAGTAGTAAAACTGCCAGCA]

4162 NM_015884.3(MBTPS2):c.l523A> 51360 MBTPS2 ['GGTGGCAGTGTACTTTTGGCTGCCARTGTG G (p.Asn508Ser) ACCCTGGGACTCTGGATGGTT']

4163 m. l0450A>G 4573 MT-TR ['ACGAATGATTTCGACTCATTAAATTRTGAT

AATCATATTTACCAAATGCCC]

4164 m.5816A>G 4511 MT-TC ['GAATTTGCAATTCAATATGAAAATCRCCTC

GGAGCTGGTAAAAAGAGGCCT']

4165 m.608A>G 4558 MT-TF ['GTAGCTTACCTCCTCAAAGCAATACRCTGA AAATGTTTAGACGGGCTCACA]

4166 NM_172337.2(OTX2):c.674A>G 5015 OTX2 ['CTGATTGAGATGGCTGGTGACTGCAYTGG (p.Asn225Ser) TACCCATGGGACTGAGTGTGGC]

4167 NM_001376.4(DYNClHl):c.917A 1778 DYNC1H1 ['CTCCTGACTCTGGATATCTTGAAACRTGGC >G (p.His306Arg) AAGCGCTTCCATGCCACCGTC]

4168 NM_001376.4(DYNClHl):c.2011 1778 DYNC1H1 ['GAAGCGGGTGGAAGATGTCCTTGGCRAGG A>G (p.Lys671Glu) GCTGGGAGAATCACGTGGAGGG]

4169 NM_001376.4(DYNClHl):c.2909 1778 DYNC1H1 ['CTAAGAATAACCAATCAGGTAATCTRCTTG A>G (p.Tyr970Cys) AATCCACCAATTGAAGAGTGC]

4170 NM_004380.2(CREBBP):c.2728A> 1387 CREBBP ['ACTGTAGGGGTGCTCTGGGTTTGGGHAGC G (p.Thr910Ala) ACTGGGCACTGAGCCAGGAGTC]

4171 NM_000459.4(TEK):c.2690A>G 7010 TEK ['ATGCTCTCTTCCTTCCCTCCAGGCTVCTTGT (p.Tyr897Cys) ACCTGGCCATTGAGTACGCG]

4172 NM_001354.5(AKRlC2):c.235A> 1646 AKR1C2 ['AGATGGCAGTGTGAAGAGAGAAGACRTAT G (p.Ile79Val) TCTACACTTCAAAGGTACTGTG]

4173 NM_007315.3(STATl):c.604A>G 6772 STAT1 ['ACAAGAACAGCTGTTACTCAAGAAGRTGT (p.Met202Val) ATTTAATGCTTGACAATAAGAG]

4174 NM_007315.3(STATl):c.494A>G 6772 STAT1 ['GAGCATGAAATCAAGAGCCTGGAAGRTTT (p.Aspl65Gly) ACAAGATGAATATGACTTCAAA']

4175 NM_007315.3(STATl):c.862A>G 6772 STAT1 ['GTTGGAGGAATTGGAACAGAAATACRCCT (p.Thr288Ala) ACGAACATGACCCTATCACAAA]

4176 NM_002052.4(GATA4):c.928A>G 2626 GATA4 ['CCTCCAGGTCCCCAGGCCTCTTGCARTGCG (p.Met310Val) GAAAGAGGGGATCCAAACCAG]

4177 NM_014191.3(SCN8A):c.5302A>G 6334 SCN8A ['CATGTACATTGCCATCATCCTGGAGRACTT (p.Asnl768Asp) CAGTGTAGCCACAGAGGAAAG]

4178 NM_000209.3(PDXl):c.533A>G 3651 PDX1 ['TACATCTCACGGCCGCGCCGGGTGGRGCT (p.Glul78Gly) GGCTGTCATGTTGAACTTGACC]

4179 NM_000890.3(KCNJ5):c.472A>G 3762 KCNJ5 ['CATTGGGTATGGCTTCCGAGTCATCRCAGA (p.Thrl58Ala) GAAGTGTCCAGAGGGGATTAT']

4180 NM_000256.3(MYBPC3):c.2234A 4607 MYBPC3 ['ACGGTCGAGGGGGCAGAGAAGGAAGRTG >G (p.Asp745Gly) AGGGCGTCTACACGGTCACAGTG]

4181 NM_005359.5(SMAD4):c.l498A> 4089 SMAD4 ['TGTTGATGACCTTCGTCGCTTATGCRTACT G (p.Ile500Val) CAGGATGAGTTTTGTGAAAGG]

4182 NM_005359.5(SMAD4):c.l500A> 4089 SMAD4 ['TTGATGACCTTCGTCGCTTATGCATRCTCA G (p.Ile500Met) GGATGAGTTTTGTGAAAGGCT']

4183 NM_001184.3 ( ATR) : c.6431 A>G 545 ATR ['TATCAATTTTTGACTGCTTTTTCACRATTGA (p.Gln2144Arg) TCTCTCGAATTTGTCATTCT']

4184 NM_153427.2(PITX2):c.262A>G 5308 PITX2 ['CCCCAACCGCCCCCAGGTTTGGTTCRAGAA (p.Lys88Glu) TCGTCGGGCCAAATGGAGAAA']

4185 NM_005257.5(GATA6):c. l354A> 2627 GATA6 ['CTGTGCCAACTGTCACACCACAACTRCCAC G (p.Thr452Ala) CTTATGGCGCAGAAACGCCGA]

4186 NM_005257.5(GATA6):c. l396A> 2627 GATA6 ['AAACGCCGAGGGTGAACCCGTGTGCVATG G (p.Asn466Asp) CTTGTGGACTCTACATGAAACT']

4187 M_000414.3(HSD17B4):c.650A> 3295 HSD17B4 ['CTTGTGGAAGCCCTGAAGCCAGAGTRTGT G (p.Tyr217Cys) GGCACCTCTTGTCCTTTGGCTT']

4188 NM_004153.3(ORCl):c.380A>G 4998 ORC1 ['GCCTGTGACAGCAACATTAATGCGGRGAC (p.Glul27Gly) CATCATTGGCCTTGTTCGGGTA']

4189 NM_002552.4(ORC4):c.521A>G 5000 ORC4 ['CATCATAAAAACCAAACACTTCTCTRTAAT (p.Tyrl74Cys) CTTTTTGACATTTCTCAGTCT']

4190 NM_004656.3(BAPl):c.2057- 8314 BAP1 ['GCTCCACTAGGTTGGCCAGCATGCCYGCG 2A>G AAGAGGTAGAGACCCTTGAGCA']

4191 NM_004656.3(BAPl):c.438-2A>G 8314 BAP1 ['TCAGGGAGGTGGCGTGGCTCGGGCCYGGG

GAAAAACAGAGTCAGGGCCCAA']

NM_003590.4(CUL3):c.l238A>G 8452 CUL3 []

(p.Asp413Gly)

4192 NM_004813.2(PEX16):c.992A>G 9409 PEX16 ['TACTTGCCCACCTGGCAGAAAATCTRCTTC (p.Tyr331Cys) TACAGTTGGGGCTGACAGACC]

4193 M_004544.3 (NDUFA10) :c .1 A>G 4705 NDUFA10 ['TTGATCCTGAGCTGACCGGGTAGCCRTGGC (p.MetlVal) CTTGCGGCTCCTGAAGCTGGC]

4194 M_004544.3(NDUFA10):c.425A 4705 NDUFA10 ['TGGTTGTACAGCAGTCGCCTGCTGCRGTAC >G (p.Glnl42Arg) TCAGATGCCTTGGAGCACTTG]

4195 NM_006796.2(AFG3L2):c.l996A> 10939 AFG3L2 ['TATTTTTCAGATTGTTCAGTTTGGCDTGAA G (p.Met666Val) TGAAAAGGTTGGGCAAATCTC]

4196 NM_006796.2(AFG3L2):c.l847A> 10939 AFG3L2 ['TATTTACCAAAAGAACAATACCTCTRTACC G (p.Tyr616Cys) AAAGAGCAGCTCTTGGATAGG]

4197 NM_001199397.1(NEKl):c.869- 4750 NEK1 ['CAAAATTCTTTGTATCTTTTCATCTRGCTA 2A>G AAAGACCAGCTTCAGGACAAA']

4198 NM_006587.3 (CORIN) :c .949 A>G 10699 CORIN ['GAATCTGTTTCACTGTCACACAGGCRAGTG (p.Lys317Glu) CCTTAATTACAGCCTTGTGTG]

4199 NM 006587.3 (CORIN) :c .1414 A>G 10699 CORIN ['CATGAATTTGCCCTACAACAGTACARGTTA (p.Ser472Gly) TCCAAATTATTTTGGCCACAG]

4200 NM_015560.2(OPAl):c.l294A>G 4976 OPA1 ['AGCTTACATGCAGAATCCTAATGCCRTCAT (p.Ile432Val) ACTGTGTATTCAAGGTAAATC]

4201 NM_021625.4(TRPV4):c.l805A>G 59341 TRPV4 ['CGTGGGCTGAAGCTGACGGGGACCTRTAG (p.Tyr602Cys) CATCATGATCCAGAAGGTACGG]

4202 NM_021625.4(TRPV4):c.590A>G 59341 TRPV4 ['TCTACGGGGAAGACCTGCCTGCCCARGGC (p.Lysl97Arg) CTTGCTGAACCTGAGCAATGGC]

4203 NM_021625.4(TRPV4) :c.826 A>G 59341 TRPV4 ['GGCCCGTGGGCGCTTCTTCCAGCCCRAGG (p.Lys276Glu) ATGAGGGGGGCTACTTCTACTT']

4204 NM_024022.2(TMPRSS3):c.308A> 64699 TMPRSS3 ['GTCTCGGATTGCAAAGACGGGGAGGRCGA G (p.Aspl03Gly) GTACCGCTGTGGTAAGGTCATG]

4205 NM_016599.4(MYOZ2):c.738A>G 51778 MYOZ2 ['GATGGATATCTGAGAATATTCCTATRGTGA (p.Ile246Met) TAACAACCGAACCTACAGATG]

NM_017415.2(KLHL3):c. l670A>G 26249 KLHL3 []

(p.Tyr557Cys)

4206 NM_019109.4(ALGl):c. l l29A>G 56052 ALG1 ['GTCCTCCAGTGGCCTGGACCTGCCCRTGAA (p.Met377Val) GGTGGTGGACATGTTCGGGTG]

4207 NM_031885.3(BBS2):c.472-2A>G 583 BBS2 ['GCTAATGGTTTGGGGTTTTATTTTCRGGTT ACTGGAGACAATGTTAATTCC]

4208 NM_006886.3(ATP5E):c.35A>G -1 ['TACCTTCTCTCATTTTCTCCCAGCTRCATCC (p.Tyrl2Cys) GATACTCCCAGATCTGTGCA']

4209 NM_022445.3(TPKl):c.656A>G 27010 TPK1 ['CACAACACCAGACCCGTCGTAGGTAYTGG (p.Asn219Ser) AAGTACTGACCAATGTTCCAAA']

4210 NM_000017.3(ACADS):c. l031A> 35 ACADS ['CTCTGACTGTACCCCCATGTTTAGGRGGCA G (p.Glu344Gly) GCCATGGCCAAGCTGGCCGCC]

4211 NM_016013.3(NDUFAFl):c.758A 51103 NDUFAF1 ['GGGGGACCCTACTGGCAGGAGGTCARGGT >G (p.Lys253Arg) AACAGCATAAATCTTCATTGTT']

4212 NM_032580.3 (HES7) :c .172 A>G 84667 HES7 ['GAACCCGAAGCTGGAGAAAGCGGAGRTAT (p.Ile58Val) TGGAGTTCGCCGTGGGCTACTT']

4213 NM_024887.3 (DHDD S) : c.124 A>G 79947 DHDDS ['GGACGGGAACCGTCGCTATGCCAAGRAGT (p.Lys42Glu) GCCAGGTGGAGCGGCAGGAAGG]

4214 NM_024700.3(SNIPl):c.l097A>G 79753 SNIP1 ['CTCAAATTTGGATTCAGTAGCAGAGRATA (p.Glu366Gly) CGTCTTGCTCCATGAGTCGTCG]

4215 NM_206933.2(USH2A):c.7595- 7399 USH2A ['AATTGAACACCTCTCCTTTCCCAAGRTAAG 2144A>G AGATCATCTTTAAGAAAAGGC]

4216 NM_016952.4(CDON):c.2368A>G 50937 CDON ['GTTTTTGTTTTCCCTCAAAGGTTCARCATA (p.Thr790Ala) CAAATTTAGGGTCATTGCCAT']

4217 NM_020435.3(GJC2):c.-167A>G 57165 GJC2 ['AGACCCTGAGGCCGAGGGGGGAACARTGG

GGCCCTTGAGGGCCCCTCCTCC]

4218 NM_024549.5(TCTNl):c.221- 79600 TCTN1 ['TGGATCCTACCCCTCTTTTTTCTGCRGTTGC 2A>G TGTTCTCTGTGTCTGTGACT']

4219 NM_031427.3(DNALl):c.449A>G 83544 DNALl ['CTCGAAGACCTGGTGTTTGTAGGCARTCCC (p.Asnl50Ser) TTGGAAGAGAAACATTCTGCT']

4220 M_145046.4(CALR3):c.245A>G 12597 CALR3 ['AGTTTTCCCTTTATTGCTGAACGGTYTGAA (p.Lys82Arg) 2 GCGTGCAGAGATGGCATAGAA']

4221 NM_020320.3 (RARS2) :c .1024 A>G 57038 RARS2 ['AATGGACAAGTATAATTTTGATACARTGAT (p.Met342Val) ATATGTGGTAAGTAATCAGAA']

4222 NM_020320.3(RARS2):c.35A>G 57038 RARS2 ['CTCTGCGCGCTCCGGGATCCATACCYGGC (p.Glnl2Arg) AAGCAATAGCGCGGCGAAAGCC]

4223 NM_001017361.2(KHDC3L):c.lA 15428 KHDC3L ['TGTCTCCTGCAGGACCGGCCGCAGCRTGG >G (p.MetlVal) 8 ACGCTCCCAGGCGGTTTCCGAC]

4224 NM_024753.4(TTC21B):c.2758- 79809 TTC21B ['TAATCGTGCCAGTTCCAACATAATCYGTAG 2A>G AGCAAAGGGCTAGATTCATCA]

4225 NM_001145901.1(SARS2):c.l l75 54938 SARS2 ['TTCGTCCTTGACCGCAGGGTCCTGGRTATG A>G (p.Asp392Gly) CCCACCCAAGAACTGGGCCTC]

4226 NM_000552.3(VWF):c.3437A>G 7450 VWF ['AACGGGTATGAGTGTGAGTGGCGCTRTAA (p.Tyrl l46Cys) CAGCTGTGCACCTGCCTGTCAA']

4227 NM_014985.3(CEP152):c.2000A> 22995 CEP152 ['ACCTTACCTATCCACAGCTTCTTGTYTGTC G (p.Lys667Arg) ATGGTCAAAATCTTGTACCAT']

4228 NM_024809.4(TCTN2):c. l506- 79867 TCTN2 ['GCTGAGAAATGTCTTACTCTCTTGCRGGGA 2A>G GAATGCTGTTGAAAGACTTGA']

4229 NM_198994.2(TGM6):c.980A>G 34364 TGM6 ['CGGACCCTGGAGGACCTGACAGAAGRCAG (p.Asp327Gly) 1 CATGTGGTGGGTCCTGCCCCCA']

4230 NM_052873.2(IFT43):c.lA>G 11275 IFT43 ['GAAGTGACGTCAGGCGGCCGCGGAGRTGG (p.MetlVal) 2 AGGATTTGCTCGACTTGGACGA']

4231 NM_201269.2(ZNF644):c.2014A> 84146 ZNF644 ['AACATTTGGATCAACCTCACAATCARGTA G (p.Ser672Gly) GTTTTTCAAAAATTCATAAGCG]

4232 NM_201269.2(ZNF644):c.l759A> 84146 ZNF644 ['GTAGTAAAAGGACACATCTTACATAYGTA G (p.Ile587Val) GGTAGCTGATTTTTTGGATGAT']

4233 NM_018699.3(PRDM5):c.320A>G 11107 PRDM5 ['TTTCAGGAAGGAGAAAACATTTTCTRTTTG (p.Tyrl07Cys) GCAGTTGAAGATATAGAAACA']

4234 NM_001198799.2(ASCCl):c.953A 51008 ASCC1 ['CTATAGTTCTCTGGGGGACTTACCAYTGGG >G (p.Asn318Ser) GTCTTTCCTGAATAGTGTATT']

4235 NM_007055.3(POLR3A):c.2554A> 11128 POLR3A ['ACCAACTGAGTTTTTCTTCCACACARTGGC G (p.Met852Val) CGGCCGGGAAGGTCTAGTCGA']

4236 NM_001256047.1(C19orfl2):c.391 83636 C19orfl2 ['TACTGGATCTCGGCCCGCAGCTCCTYGGTG A>G (p.Lysl31Glu) ACGTAGTTCACCAGCATGGCC]

4237 M_016464.4(TMEM138):c.287A 51524 TMEM138 ['TACTTTGCCCTCAGCATCTCCCTTCRTGTCT >G (p.His96Arg) GGGTCATGGTAAGAGTGGCA']

4238 M_016464.4(TMEM138):c.389A 51524 TMEM138 ['TTCCTCCCCACAGCAGCAGTGTTGTRCTGC >G (p.Tyrl30Cys) TACTTCTATAAACGGACAGCC]

4239 NM_177965.3(C8orf37):c.545A>G 15765 C8orf37 ['AAAGGAACACGGGCATATGCCTGCCRGTG (p.Glnl82Arg) 7 TAGCTGGAGAACTATTGAAGAA']

4240 NM_001004334.3(GPR179):c.659A 44043 GPR179 ['CCCAAGTGGCCGCAGGCAGATGGATRTGT >G (p.Tyr220Cys) 5 GGGGGACACGCAGCAGGTGAGG]

4241 NM_004963.3(GUCY2C):c.l l60A 2984 GUCY2C ['AGCAGTGAGACATACTTTCTTGGTGYCCAC >G (p.Asp387Gly) AGAGGTATACAGAAGCACCAT']

4242 NM_024110.4(CARD14):c.425A> 79092 CARD14 ['AGCCTGCAGGAGGAGCTGAACCAGGRAAA G (p.Glul42Gly) GGGGCAGAAGGAGGTGCTGCTG]

4243 NM_018105.2(THAPl):c.70A>G 55145 THAP1 ['CAAGGACAAGCCCGTTTCTTTCCACRAGTG (p.Lys24Glu) AGGACCCTGCGCGCCTCGCGG]

4244 NM_000933.3 (PLCB4) :c.1868 A>G 5332 PLCB4 ['AACAAACGGCAAATGAGTCGCATTTRCCC (p.Tyr623Cys) CAAGGGAGGCCGAGTCGATTCC]

4245 NM_001172646.1(PLCB4):c.986A 5332 PLCB4 ['CACTACTTCATCAGTTCTTCCCATAVCACT >G (p.Asn329Ser) TATCTCACTGGCAGACAGTTC]

4246 NM_005850.4(SF3B4):c.lA>G 10262 SF3B4 ['GGGAGACGGCGGGATCTCTTTCGCCRTGG (p.MetlVal) CTGCCGGGCCGATCTCCGAGCG]

4247 M_014714.3(IFT140):c.932A>G 9742 IFT140 ['TGGGACATAGAACGAGGAGAGAATTRTAT (p.Tyr311Cys) ACTGAGTCCAGATGAGAAGTTT']

4248 NM_000258.2(MYL3):c.517A>G 4634 MYL3 ['GACAGAAGACGAAGTGGAGAAGTTGRTGG (p.Metl73Val) CTGGGCAAGAGGACTCCAATGG]

4249 NM_032578.3(MYPN):c.59A>G 84665 MYPN ['ATATCTCAGCTTCTAAGAGAGAGCTRTTTA (p.Tyr20Cys) GCTGAAACCAGACATCGGGGA']

4250 NM_001018005.1(TPMl):c.742A> 7168 TPM1 ['TGAGTTTGCGGAGAGGTCAGTAACTRAAT G (p.Lys248Glu) TGGAGAAAAGCATTGATGACTT']

4251 NM_005006.6(NDUFSl):c.l783A> 4719 NDUFS1 ['AGCTGCTTACACAGAGAAGTCTGCTRCAT G (p.Thr595Ala) ATGTCAACACTGAGGGTAGAGC']

4252 NM_033360.3(KRAS):c.439A>G 3845 KRAS ['AATTCCTTTTATTGAAACATCAGCARAGAC (p.Lysl47Glu) AAGACAGGTAAGTAACACTGA]

4253 NM_014236.3(GNPAT):c. l556A> 8443 GNPAT ['GAAGATGAACTCATCTGCAAAAACAHCAC G (p.Asp519Gly) GTAGGAAGCGAAAGCAACTGTA']

4254 NM_017565.3(FAM20A):c.813- -1 ['GGCACCCGTCGGAAGTCCAGAATCCYGCA 2A>G AGAGAGGAAGCTCTGTTCCATC]

4255 NM_017565.3(FAM20A):c.590- 54757 FAM20A ['AGGCTTTCTCATCTTGACTGTAATCYGCAA 2A>G AGGAGGAGAAGGGCAATGAGA']

4256 NM_017636.3(TRPM4):c.2741A> 54795 TRPM4 ['CTGCTTCACATCTTCACGGTCAACARACAG G (p.Lys914Arg) CTGGGGCCCAAGATCGTCATC]

4257 NM_000076.2(CDKNlC):c.832A> 1028 CDKN1C ['GCTGTCGCCCGCAGATTTCTTCGCCRAGCG G (p.Lys278Glu) CAAGAGATCAGCGCCTGAGAA]

4258 NM_022912.2(REEPl):c.304- 65055 REEP1 ['AGTGTGCCTCTGTTTTTCCTTTGACRGGAA 2A>G ATCGATGATTGTCTGGTCCAA']

4259 NM_000053.3(ATP7B):c.2305A>G 540 ATP7B ['TGTGACATTCTTCGACACGCCCCCCRTGCT (p.Met769Val) CTTTGTGTTCATTGCCCTGGG]

4260 NM_000053.3(ATP7B):c.3620A>G 540 ATP7B ['GTCCACACCCATGCTCTGCAGCGTGYGCA (p.Hisl207Arg) CAGCCAGGGCAGCCTCCTGCTT']

4261 NM_000492.3(CFTR):c.3140- 1080 CFTR ['ACATTTTGTGTTTATGTTATTTGCARTGTTT 26A>G TCTATGGAAATATTTCACAG]

4262 NM_000570.4(FCGR3B):c. l94A> 2215 FCGR3B ['GCTCGAGGCCTGGCTTGAGATGAGGYTCT G (p.Asn65Ser) CATTGTGAAACCACTGTGTGGA]

4263 NM_198253.2(TERT):c.2705A>G 7015 TERT ['TATGGCTGCGTGGTGAACTTGCGGARGAC (p.Lys902Arg) AGTGGTGAACTTCCCTGTAGAA']

4264 NM_005022.3(PFNl):c.350A>G 5216 PFN1 ['GTTGATCAAACCACCGTGGACACCTYCTTT (p.Glul l7Gly) GCCCATCAGCAGGACTAGCGC]

4265 NM_005349.3(RBPJ):c. l88A>G 3516 RBPJ ['GTTGCACAGAAGTCATATGGAAATGRAAA (p.Glu63Gly) AAGGTAAGATTATTTTTCTGGT']

4266 NM_005349.3(RBPJ):c.505A>G 3516 RBPJ ['GATAAAAGTCATCTCCAAACCTTCCRAAA (p.Lysl69Glu) AGAAGCAGTCATTGAAAAATGC]

4267 NM_022787.3(NMNATl):c.817A> 64802 NMNAT1 ['GGTCATCCTGGCCCCTTTGCAGAGARACAC G (p.Asn273Asp) TGCAGAAGCTAAGACATAGGA]

4268 NM_020921.3(NIN):c.3665A>G 51199 NIN ['CACAGAAACATCAAAAAGTAGGTCCYGTT (p.Glnl222Arg) TCTTTTCAGAAGCTCGATCACA']

4269 NM_020921.3 (NIN) :c .5126 A>G 51199 NIN ['AAAATCTCTAGTGTTCTAAGCTACARCGAA (p.Asnl709Ser) AAACTGCTGAAAGAAAAGGAA']

4270 NM_005340.6(HINTl):c.152A>G 3094 HINT1 ['GACATTTCCCCTCAAGCACCAACACRTTTT (p.His51Arg) CTGGTGATACCCAAGAAACAT']

4271 NM_005050.3(ABCD4):c.956A>G 5826 ABCD4 ['GAGCTGGGTGAAGCAGCTGATGAGGYAGA (p.Tyr319Cys) TGCACACAAAGGCATTCTGGAC]

4272 NM_000155.3(GALT):c.950A>G 2592 GALT ['GCTGGGGCCAACTGGAACCATTGGCRGCT (p.Gln317Arg) GCACGCTCATTACTACCCTCCG]

4273 NM_007294.3(BRCAl):c.213- 672 BRCA1 ['ACTTGCTGAGTGTGTTTCTCAAACARTTTA 12A>G ATTTCAGGAGCCTACAAGAAA]

4274 NM_007294.3(BRCAl):c.4096+3A 672 BRCA1 ['GCAAAGCATGGATTCAAACTTAGGTRTTG >G GAACCAGGTTTTTGTGTTTGCC]

4275 NM_007294.3(BRCAl):c.5194- 672 BRCA1 ['TGATGGGTTGTGTTTGGTTTCTTTCVGCAT 2A>G GATTTTGAAGTCAGAGGAGAT']

4276 NM_007294.3(BRCAl):c.5453A> 672 BRCA1 ['GTGCAGCCAGATGCCTGGACAGAGGRCAA G (p.Aspl818Gly) TGGCTTCCATGGTAAGGTGCCT']

4277 NM_000059.3(BRCA2):c.l799A> 675 BRCA2 ['TATGCTATACATGATGAAACATCTTRTAAA G (p.Tyr600Cys) GGAAAAAAAATACCGAAAGAC]

4278 NM_000059.3(BRCA2):c.476- 675 BRCA2 ['ACAATTTTCCCCTTTTTTTACCCCCRGTGGT 2A>G ATGTGGGAGTTTGTTTCATA']

4279 NM_000059.3 (BRC A2) :c .8168 A> 675 BRCA2 ['AAAGTGGCCATTATTGAACTTACAGNTGG G (p.Asp2723Gly) GTGGTATGCTGTTAAGGCCCAG]

4280 NM_000059.3(BRCA2):c.8633- 675 BRCA2 ['GAATTAATAATCCTTTTGTTTTCTTDGAAA 2A>G ACACAACAAAACCATATTTAC]

4281 NM_000060.3(BTD):c.629A>G 686 BTD ['AATAATGGAACCCTTGTTGACCGCTRCCGT (p.Tyr210Cys) AAACACAACCTCTACTTTGAG]

4282 NM_000060.3(BTD):c.968A>G 686 BTD ['ACCCCTCTGGAGTCCTTTTGGTACCRTGAC (p.His323Arg) ATGGAAAATCCCAAAAGTCAC]

4283 NM_000155.3(GALT):c.857A>G 2592 GALT ['ATCATGAAGAAGCTCTTGACCAAGTRTGA (p.Tyr286Cys) CAACCTCTTTGAGACGTCCTTT']

4284 NM_000060.3(BTD):c.l28A>G 686 BTD ['TGTTACGTGGTTGCCCTGGGAGCCCRCACC (p.His43Arg) GGGGAGGAGAGCGTGGCTGAC]

4285 NM_002437.4(MPV17):c.262A>G 4358 MPV17 ['CACCACCAAAGTGGATGCACTGAAGRAGA (p.Lys88Glu) TGTTGTTGGATCAGGTGAGCAG]

4286 NM_002769.4(PRSSl):c.65A>G -1 ['GTTGCTGCCCCCTTTGATGATGATGRCAAG (p.Asp22Gly) ATCGTTGGGGGCTACAACTGT']

4287 NM_005211.3(CSFlR):c.2320- 1436 CSF1R ['GACTAACCCTGCAGTGCTTTCCCTCRGTGC 2A>G ATCCACCGGGACGTGGCAGCG]

4288 NM_024312.4(GNPTAB):c.118- 79158 GNPTAB ['GAAAACGTTTCTTTTTCTTTGTTCTRGGTG 2A>G GTTCTGGAATGGAGCCGAGAT']

4289 NM_000495.4(COL4A5):c.3107- 1287 COL4A5 ['AAATATTATATATCACATATTTTCARCAGG 4A>G GCCTCAGGGTGTGGAAGGGCC]

4290 NM_000282.3(PCCA):c.862A>G 5095 PCCA ['TGGGAATGCTTTATGGCTTAATGAANGAG (p.Arg288Gly) AGTGCTCAATTCAGAGAAGAAA']

4291 NM_000288.3(PEX7):c.854A>G 5191 PEX7 ['TCTCTTCTTGAAACAGTGGAGCATCRTACA (p.His285Arg) GAGTTTACTTGTGGTTTAGAC]

4292 NM_000532.4(PCCB):c.l606A>G 5096 PCCB ['ACAACGTCCTTGGAGAAAACATGCARATA (p.Asn536Asp) TTCCATTGTAAACAAATCAAAG]

4293 NM_000553.4(WRN):c.2089- 7486 WRN ['TCAAAGGAAAAATACATTTAAGATTVTAA 3024A>G GTCTGGTTATAAGCTTAAAAAG]

4294 NM_001039958.1(MESP2):c.271A 14587 MESP2 ['GCGGCAGAGCGCCAGCGAGCGGGAGRAA >G (p.Lys91Glu) 3 CTGCGCATGCGCACGCTGGCCCG]

4295 NM_001099274.1(TINF2):c.850A> 26277 TINF2 ['TAGGGGAGGCCATAAGGAGCGCCCCRCAG G (p.Thr284Ala) TCATGCTGTTTCCCTTTAGGAA]

4296 NM_001099274.1(TINF2):c.871A> 26277 TINF2 ['CCCCACAGTCATGCTGTTTCCCTTTRGGAA G (p.Arg291Gly) TCTCGGCTCACCAACCCAGGT']

4297 NM_001363.4(DKCl):c.l l5A>G 1736 DKC1 ['ACAACACGCTGAAGAATTTCTTATCRAACC (p.Lys39Glu) TGAATCCAAAGTTGCTAAGTT']

4298 NM_001363.4(DKCl):c.l27A>G 1736 DKC1 ['AGAATTTCTTATCAAACCTGAATCCRAAGT (p.Lys43Glu) TGCTAAGTTGGACACGTCTCA']

4299 NM_001363.4(DKCl):c.l96A>G 1736 DKC1 ['GAATTTTGATAAGCTGAATGTAAGGRCAA (p.Thr66Ala) CACACTATACACCTCTTGCATG]

4300 NM_001363.4(DKCl):c.941A>G 1736 DKC1 ['GTAAATGCCATCTGCTATGGGGCCARGATT (p.Lys314Arg) ATGCTTCCAGGTGTTCTTCGA']

4301 M_004614.4(TK2):c.l73A>G 7084 TK2 ['GCATGTCGTCTTCCCACTTGCAATAYTGCC (p.Asn58Ser) CTCGACACAGATCTGGCAAAA]

4302 M_004614.4(TK2):c.278A>G 7084 TK2 ['AACCAACAACCCACTCACCAGAGGAYTGT (p.Asn93Ser) GGCCACGGACATTTCTCCACTT']

4303 M_004614.4(TK2):c.562A>G 7084 TK2 ['AGTTTACCTTCGGACCAATCCTGAGRCTTG (p.Thrl88Ala) TTACCAGAGGTTAAAGAAGAG]

4304 NM_024312.4(GNPTAB):c.1285- 79158 GNPTAB ['TTTATTTTCTCTTTGGTTTTATCGTRGGTTT 2A>G ATTTGACATGGCCTGTGCCA']

4305 NM_024312.4(GNPTAB):c.2867A 79158 GNPTAB ['TTCACATCGCGGAAAGTCCCTGCTCRCATG >G (p.His956Arg) CCTCACATGATTGACCGGATT']

4306 NM_024312.4(GNPTAB):c.3458A 79158 GNPTAB ['AGGAAGTTTGTTTGCCTGAATGACARCATT >G (p.Asnl l53Ser) GACCACAATCATAAAGATGCT']

4307 NM_024312.4(GNPTAB):c.2783A 79158 GNPTAB ['AGCAAAAATACTGGGAGGCAACTAARAGA >G (p.Lys928Arg) TACATTTGCAGATTCCCTCAGA']

4308 NM_198253.2(TERT):c.2537A>G 7015 TERT ['TCCACGCTGCTCTGCAGCCTGTGCTRCGGC (p.Tyr846Cys) GACATGGAGAACAAGCTGTTT']

4309 NM_198578.3(LRRK2):c.3342A>G 12089 LRRK2 ['TAGAGAAACTGGAGCAGCTCATTTTRGAA (p.Leul ll4=) 2 GGGTAAGAAAGAGCTCATTAAA']

4310 NM_198578.3(LRRK2):c.5605A>G 12089 LRRK2 ['TTTGGCTGACCTGCCTAGAAATATTRTGTT (p.Metl869Val) 2 GAATAATGATGAGTTGGAATT']

4311 NM_207352.3 (CYP4 V2) :c .367 A>G 28544 CYP4V2 ['TTCAAAGCAAATTGACAAATCCTCTRTGTA (p.Metl23Val) 0 CAAGTTTTTAGAACCATGGCT']

4312 NM_207352.3(CYP4V2):c.761A>G 28544 CYP4V2 ['CTTATGTTTAAAGAAGGATGGGAACRCAA (p.His254Arg) 0 AAAGAGCCTTCAGATCCTACAT']

4313 NR_001566.1 (TERC) : n.37 A>G 7012 TERC ['GGTGGGCCTGGGAGGGGTGGTGGCCDTTT

TTTGTCTAACCCTAACTGAGAA']

4314 NR_001566.1(TERC):n.48A>G 7012 TERC ['GAGGGGTGGTGGCCATTTTTTGTCTRACCC

TAACTGAGAAGGGCGTAGGCG]

4315 NM_007171.3(POMTl):c.430A>G 10585 POMT1 ['CATGTGTTTCCTCTTTGAAACAGAGRATGC (p.Asnl44Asp) TCTCATCACTCAGTCAAGGCT']

4316 NM_003863.3(DPM2):c.68A>G 8818 DPM2 ['GCCGTTAGCCTGATCATCTTCACCTRCTAC (p.Tyr23Cys) ACCGCCTGGGTGATTCTCTTG]

4317 NM_000030.2(AGXT):c.1020 A>G 189 AGXT ['GGAGAGACATCGTCAGCTACGTCATRGAC (p.Ile340Met) CACTTCGACATTGAGATCATGG]

4318 NM_031418.2(ANO3):c.2053A>G 63982 AN03 ['TTATGTTCTATTTCAGTGTCATCCTRGTGG (p.Ser685Gly) CTGTTTGATAGACCTCTGCCT']

4319 NM_183075.2(CYP2Ul):c.l l39A> 11361 CYP2U1 ['CCTTTTTACATAGAAAAGGTTCATGRAGAA G (p.Glu380Gly) 2 ATTGAAAGAGTCATTGGCGCC]

4320 NM_003094.3(SNRPE):c.lA>G 6635 SNRPE ['GGTGTGCTCTTTGTGAAATTCCACCRTGGC (p.MetlVal) GTACCGTGGCCAGGGTCAGAA']

4321 M_000344.3(SMNl):c.389A>G 6606 SMN1 ['ACCTGTGTTGTGGTTTACACTGGATRTGGA (p.Tyrl30Cys) AATAGAGAGGAGCAAAATCTG]

4322 NM_012082.3(ZFPM2):c.2209A>G -1 ['CATGCAGAGAACCATGCGCACACGCRAGC (p.Lys737Glu) GCAGAAAGATGTATGAGATGTG]

4323 NM_006364.2(SEC23A):c.2104A> 10484 SEC23A ['TGTTCAGTGTCAATGTATCTTGGCAYTGGA G (p.Met702Val) AATCTGGAGTGAAGAATTTCC]

4324 NM_001139.2(ALOX12B):c.l562A 242 ALOX12B ['ACCCTCCACGGCTGCGTCACTCGGGYAAT >G (p.Tyr521Cys) AATAGGTGATGATCTCCGTCAC]

4325 NM_001004434.2(SLC30A2):c. l61 7780 SLC30A2 ['GTGACTGTCAGGACCCTTCTGAGCAYGGC A>G (p.His54Arg) AGTGATGGTTGCTCTGGGCAGC]

4326 NM_001168272.1(ITPRl):c. l759A 3708 ITPR1 ['CACTATCACTGCCCTGCTCCACAATRATCG >G (p.Asn587Asp) GAAACTCCTGGAAAAACACAT']

4327 m.15923 A>G -1 ['ATAAACTAATACACCAGTCTTGTAARCCG

GAGATGAAAACCTTTTTCCAAG]

4328 NM_007332.2(TRPAl):c.2564A>G -1 ['TTTTTTTACTTTTCTAGATTTGAAARTTGTG (p.Asn855Ser) GAATTTTTATTGTTATGTTG]

4329 NM_014254.2(TMEM5):c.l016A> 10329 TMEM5 ['CCGGTCGGAGTAAACACAGAATGCTRTCG G (p.Tyr339Cys) AATCTATGAGGCTTGCTCCTAT']

4330 NM_144577.3(CCDC114):c.487- 93233 CCDC114 ['ACTGATTTTTTTCTCCTCCCCCCACRGGAG 2A>G ATCCACCACCTGCATCACCTG]

4331 NM_000834.3(GRIN2B):c.2172- 2904 GRIN2B ['GGATTTGTTTGCTTTTTTCCTGTACRGGAA 2A>G ACTGGATGCCTTCATCTATGA']

4332 NM_018486.2(HDAC8):c.539A>G 55869 HDAC8 ['ATTCTCTACGTGGATTTGGATCTGCRCCAT (p.Hisl80Arg) GGAGATGGTAAGCCCTTTGGT']

4333 NM_018486.2(HDAC8):c.l001A> 55869 HDAC8 ['ACACTATCCTCTGAGATCCCAGATCRTGAG G (p.His334Arg) GTAAGTAAGGCTCTGACAAGT']

4334 NM_178012.4(TUBB2B):c.767A> 34773 TUBB2B ['GCAGACCTGCGCAAGCTGGCGGTGARCAT G (p.Asn256Ser) 3 GGTGCCCTTCCCTCGCCTGCAC]

4335 NM_006888.4(CALMl):c.293A>G 801 CALM1 ['ATTGCTGAATGTTCACAGGATGGCARTGGT (p.Asn98Ser) TATATCAGTGCAGCAGAACTA]

4336 NM_172107.2(KCNQ2):c.l636A> 3785 KCNQ2 ['GCCCCACCCACCCCCCTGCAGTGTCRTGCG G (p.Met546Val) GTTCCTGGTGTCCAAGCGGAA]

4337 NM_001866.2(COX7B):c.41-2A>G 1349 COX7B ['TGTATTCTTTTTTCGTTTTCCTGTARGTTCG

AAGCATTCAGCAAACAATGG]

4338 NM_001099922.2(ALG13):c.339A 79868 ALG13 ['TGAACAATCATCAGCTGGAACTGGCRAAG >G (p.Alal l3=) CAGCTACACAAAGAGGGTCATC]

4339 NM_001083614.1(EARS2):c.502A 12445 EARS2 ['CCCCATCAGGTATGACAATCGGTGCRGGA >G (p.Argl68Gly) 4 ACATGAGCCAGGAGCAGGTGGC]

4340 NM_001083614.1(EARS2):c.l93A 12445 EARS2 ['TGCCTTGTACAACTACATCTTTGCTRAGAA >G (p.Lys65Glu) 4 GTACCAGGGGAGCTTCATCCT']

4341 NM_033109.4(PNPTl):c. ll60A>G 87178 PNPT1 ['ACCCTTCATGGATCAGCATTATTTCRAAGA (p.Gln387Arg) GGACAAACACAGGTAATTTAT']

4342 NM_033109.4(PNPTl):c. l424A>G 87178 PNPT1 ['CCTTTCACCATAAGAGTTACATCTGRAGTC (p.Glu475Gly) CTAGAGTCAAATGGTATGGTA]

4343 NM_000390.2(CHM):c. l520A>G 1121 CHM ['ATTTTTTTTTTAACAGATTTGGTTCRTTTGA (p.His507Arg) CTTGCACATCTTCTAAAACA']

4344 NM_181690.2(AKT3):c.686A>G 10000 AKT3 ['TTGTGTTTTGTGATGGAATATGTTARTGGG (p.Asn229Ser) GGCGAGGTGAGTCAAGAAGTA']

4345 NM_006567.3(FARS2):c.431A>G 10667 FARS2 ['CCCAGCAGGAAGAAGGGGGACAACTRTTA (p.Tyrl44Cys) CCTGAATCGGACTCACATGCTG]

4346 NM_001410.2(MEGF8):c.7099A> 1954 MEGF8 ['CAAGTGCCGGGAATCATTTCACGGGRGTC G (p.Ser2367Gly) CGCTGGGCGGCCAGCAGTGCTA]

4347 NM_003124.4(SPR):c.596-2A>G 6697 SPR ['CCTCATCGTCTCCTTTTCATCCTCTRGGTCC

TCTGGACACAGACATGCAGC]

4348 NM_005609.2(PYGM):c.l52A>G 5837 PYGM ['GACCGCAATGTGGCCACCCCACGAGRCTA (p.Asp51Gly) CTACTTTGCTCTGGCCCATACC]

4349 NM_004247.3 (EFTUD2) : c.623 A> 9343 EFTUD2 ['TTACTTAGTATTTGCTTTTCAGGACRTGTG G (p.His208Arg) AATTTCTCTGATGAGGTCACA']

4350 NM_001310338.1(MGMEl):c.743 92667 MGME1 ['GCTGTTCAACATGAAACCTTAAACTRTATA A>G (p.Tyr248Cys) GGTCTGCTGGACTGTGTGGCT']

4351 NM_001128085.1(ASPA):c.433- -1 ['AAGAAAGACGTTTTTGATTTTTTTCRGACT

2A>G TCTCTGGCTCCACTACCCTGC]

4352 NM_000108.4(DLD):c.l444A>G 1738 DLD ['TGGAGCATCCTGTGAAGATATAGCTRGAG (p.Arg482Gly) TCTGTCATGCACATCCGGTAAT']

4353 NM_007215.3(POLG2):c.l l05A>G 11232 POLG2 ['ACTAACATTAAGAACAAACAAACCCNTAT (p.Arg369Gly) TTTTAGTTTCCCAAGTCTATCT']

4354 NM_004333.4(BRAF):c.2126A>G 673 BRAF ['AGAGATGAGAGACCACTCTTTCCCCRAGT (p.Gln709Arg) AAGTAAAAGCTTCATGCTATCC]

4355 NM_004985.4(KRAS):c.65A>G 3845 KRAS ['GTAGGCAAGAGTGCCTTGACGATACDGCT (p.Gln22Arg) AATTCAGAATCATTTTGTGGAC]

4356 NM_004985.4(KRAS):c.458A>G 3845 KRAS ['ACTTTTTATGTATTTCAGGGTGTTGDTGAT (p.Aspl53Gly) GCCTTCTATACATTAGTTCGA]

4357 NM_002834.3(PTPNl l):c.l24A>G 5781 PTPN11 ['TAGTAAAAGTAACCCTGGAGACTTCRCAC (p.Thr42Ala) TTTCCGTTAGGTAAGTTGGAAT']

4358 NM_002834.3(PTPNl l):c.l72A>G 5781 PTPN11 ['AGCTGTCACCCACATCAAGATTCAGNACA (p.Asn58Asp) CTGGTGATTACTATGACCTGTA']

4359 NM_002834.3(PTPNl l):c.767A>G 5781 PTPN11 ['TTTCTTTCTTTCCAGACACTACAACRACAG (p.Gln256Arg) GAGTGCAAACTTCTCTACAGC]

4360 NM_002834.3(PTPNl l):c.844A>G 5781 PTPN11 ['CAAAAACAAAAATAGATATAAAAACRTCC (p.Ile282Val) TGCCCTGTAAGTATCAATATTC]

4361 NM_002834.3(PTPNl l):c.l510A> 5781 PTPN11 ['GATGGTGCGGTCTCAGAGGTCAGGGRTGG G (p.Met504Val) TCCAGACAGAAGCACAGTACCG]

4362 NM_002880.3(RAFl):c.524A>G 5894 RAF1 ['ACTTGTGGCTACAAATTTCATGAGCRCTGT (p.Hisl75Arg) AGCACCAAAGTACCTACTATG]

4363 NM_002880.3(RAFl):c.l279A>G 5894 RAF1 ['AATTGTGACCCAGTGGTGCGAGGGCRGCA (p.Ser427Gly) GCCTCTACAAACACCTGCATGT']

4364 NM_005633.3(SOSl):c.508A>G 6654 SOS1 ['TATTAAAGTGGCAATGTGTGCTGACRAGG (p.Lysl70Glu) TAGGAAACTGAGCTTTTCTATT']

4365 NM_030662.3 (M AP2K2) :c .181 A> 5605 MAP2K2 ['GCGGCTGGAAGCCTTTCTCACCCAGRAAG G (p.Lys61Glu) CCAAGGTCGGCGAACTCAAAGA']

4366 NM_024334.2(TMEM43):c.271A> 79188 TMEM43 ['GGAGAATGAAGGAAGGCTGGTGCACRTCA G (p.Ile91Val) TTGGCGCCTTACGGACATCCAA']

4367 NM_000084.4(CLCN5):c.l637A>G 1184 CLCN5 ['CTGATGGCTGCAGCCATGACAAGCARGTG (p.Lys546Arg) GGTGGCAGATGCTCTTGGGCGG]

4368 NM_000084.4(CLCN5):c.815A>G 1184 CLCN5 ['CCTTCTTTCTTCTAGGTCAGCTACTRTTTTC (p.Tyr272Cys) CCCTCAAAACATTGTGGCGT']

4369 NM_000095.2(COMP):c. l760A>G 1311 COMP ['GGCGTGGACTTCGAGGGCACGTTCCRTGT (p.His587Arg) GAACACGGTCACGGATGACGAC]

4370 NM_000530.6(MPZ):c.389A>G 4359 MPZ ['AATGGCACGTTCACTTGTGACGTCARAAA (p.Lysl30Arg) CCCTCCAGACATAGTGGGCAAG]

4371 NM_000530.6(MRZ):c.347A>G 4359 MPZ ['AAGGATGGCTCCATTGTCATACACARCCTA (p.Asnl l6Ser) GACTACAGTGACAATGGCACG]

4372 NM_003611.2(OFDl):c.260A>G 8481 OFD1 ['GCAGATCACTTACAAAGATGTGGCTDTGA (p.Tyr87Cys) ATATTCACTTTCTGTTTTCTTT']

4373 NM_003611.2(OFDl):c.290A>G 8481 OFD1 ['TATTCACTTTCTGTTTTCTTTCCAGRAAGTG (p.Glu97Gly) GTTTGGCAAAAGAAAAGGTA']

4374 NM_003611.2(OFDl):c.382-2A>G 8481 OFD1 ['TAAAAGTGAAATATTTTCTTTTAACRGGTT

TCAGGATCTGATAAAGAAAAT']

4375 NM_003977.3(AIP):c.721A>G 9049 AIP ['GCTGCTGCTCAACTACTGCCAGTGCDAGCT (p.Lys241Glu) GGTGGTCGAGGAGTACTACGA']

4376 NM_006158.4(NEFL):c.293A>G 4747 NEFL ['GAGAAGGCGCAGCTCCAGGACCTCARTGA (p.Asn98Ser) CCGCTTCGCCAGCTTCATCGAG]

4377 NM_024312.4(GNPTAB):c.3053A 79158 GNPTAB ['ATATCTCAAGTCTTTGATGAAGTTGRTACA >G (p.Aspl018Gly) GATCAATCTGGTGTCTTGTCT']

4378 NM_025137.3(SPGl l):c. l457- 80208 SPG11 ['TAAAGCTAACTTTTATTTTTCCTATRGAGA 2A>G ATGGACTCTCTCTGATTTTGT']

4379 NM_025137.3(SPGl l):c.2608A>G 80208 SPG11 ['ACAAGAATCCATCCTTCTCCCCAGGRTAAG (p.Ile870Val) TCCAGAAGGCAAGTGTGAGAG]

4380 NM_025137.3(SPGl l):c.2833A>G 80208 SPG11 ['GAATGAAATTTTAGATAAGCTGGCCRGGT (p.Arg945Gly) ATTATAACTGTTGAACTAATAC]

4381 NM_025137.3(SPGl l):c.6477+4A> 80208 SPG11 ['CAGTGAGGAGTATGGGCTGGTGGTARGTA G GCCCCCTCAACCCCAGTCTCCA']

4382 NM_212472.2(PRKARlA):c.l78- 5573 PRKARIA ['ATTTTGCAAACTCGTAATTTCTTTCRGGAG 2A>G GAGGCAAAACAGATTCAGAAT']

4383 NM_006231.3 (POLE) : c.4444+3 A> 5426 POLE ['CCAGTTCAGCTACCTGGAACCAGGTRTGG G CCTGCACCAGCCGCCCATCATG]

4384 NM_003156.3(STIMl):c.251A>G 6786 STIM1 ['GACGATGATGCCAATGGTGATGTGGRTGT (p.Asp84Gly) GGAAGAAAGTGATGAGGTGAGC]

4385 NM_003156.3(STIMl):c.326A>G 6786 STIM1 ['CCAACAGTGAAACACAGCACCTTCCRTGG (p.Hisl09Arg) TGAGGATAAGCTCATCAGCGTG]

4386 NM_001128425.1(MUTYH):c.934- 4595 MUTYH ['GGCTAAGAGCTGTTCCTGCTCCACCYGAG

2A>G AGGCACAGGGTTGAGTGTCATA']

4387 NM_133499.2(SYNl):c.l699A>G 6853 SYN1 ['GGCGGAGCCGGGCCAGAGACGGATGYCTG (p.Thr567Ala) ACGGGTAGCCTGTGGGGGGCCC]

4388 NM_021629.3(GNB4):c.265A>G 59345 GNB4 ['TATTTGGGATAGCTATACAACAAATRAGG (p.Lys89Glu) TAGAATTTCTTCATAATTCTTT']

4389 NM_138425.3(C12orf57):c.lA>G 11324 C12orf57 ['CTGAACCTAGAGCTTCAGACGCCCTRTGGC (p.MetlVal) 6 GTCCGCCTCGACCCAACCGGC]

4390 NM_000096.3(CP):c.2953A>G 1356 CP ['GGGAGATGAAGTCAACTGGTATCTGRTGG (p.Met985Val) GAATGGGCAATGAAATAGACTT']

4391 NM_000057.3(BLM):c. l088-2A>G 641 BLM ['AATATTAACAACATAATTATTTTATRGCTA

GACAGATAAGTTTACAGCAGC]

4392 NM_000257.3(MYH7):c.5807A>G 4625 MYH7 ['TTTCAAAAGGGCTTGAATGAGGAGTRGCT (p.Terl936Trp) TTGCCACATCTTGATCTGCTCA']

4393 NM_152263.3(TPM3):c.505A>G 7170 TPM3 ['GGATCTTTTCCTGTAGGTGGCTCGTRAGTT (p.Lysl69Glu) GGTGATCATTGAAGGAGACTT']

4394 NM_152263.3(TPM3):c.733A>G 7170 TPM3 ['AGAGACCCGTGCTGAGTTTGCTGAGRGAT (p.Arg245Gly) CGGTAGCCAAGCTGGAAAAGAC]

4395 NM_000096.3(CP):c.l209-2A>G 1356 CP ['GCATTAAACACTTTTTTCCCCCTGCRGTGA

CTCAGCGGTGTTTTTTGAACA']

4396 NM_002739.3(PRKCG):c.76A>G 5582 PRKCG ['CCTGTTTTGCAGAAAGGGGGCCCTGRGGC (p.Arg26Gly) AGAAGGTGGTCCACGAAGTCAA']

4397 NM_000138.4(FBNl):c.l l48- 2200 FBN1 ['GTGTTTTGTTTTGTTGTGTTTTTCTRGAGGA 2A>G TTTCAACAAGCTGTGCTCTG]

4398 NM_000138.4(FBNl):c.3058A>G 2200 FBN1 ['ACCCGGATTTGCCACAAAAGAAATTRCAA (p.Thrl020Ala) ATGGAAAGCCTTTCTTCAAAGG]

4399 NM_000169.2(GLA):c.1153 A>G -1 ['GGCCTGTAATCCTGCCTGCTTCATCRCACA (p.Thr385Ala) GCTCCTCCCTGTGAAAAGGAA]

4400 NM_000256.3(MYBPC3):c.l224- 4607 MYBPC3 ['ACTTCAACGGCCCCTTCTGTTCTACRGCAA 2A>G GTAAGTTCCCCTCTGGATGGC]

4401 NM_000256.3(MYBPC3):c.l814A 4607 MYBPC3 ['GTCAGCCTCGTCGGCAGGTGTGACGYCGT >G (p.Asp605Gly) CAATGGTCAGTTTGTGGACCCT']

4402 NM_000256.3(MYBPC3):c.l928- 4607 MYBPC3 ['CTCTGAACTACATTGTGTCTTCTGCRGAAC 2A>G CTCCCAAGATCCACCTGGACT']

4403 NM_000256.3(MYBPC3):c.2309- 4607 MYBPC3 ['GGGCCGCAGGTGCGTCTGGCACGTCBGGA 2A>G TGGGGTGGGATGGACCCACATC]

4404 NM_000256.3(MYBPC3):c.26- 4607 MYBPC3 ['GTGGCTTCTTGCTAAAAGCTGAGACYGAA 2A>G GGGCCAGGTGGAGGCTACAGCG]

4405 NM_000256.3(MYBPC3):c.927- 4607 MYBPC3 ['GGCCACAGCCTAGACTGCGGGACACRGGG 2A>G ACTCGAAGCTGGAGGCACCAGC]

4406 NM_000257.3(MYH7):c.2206A>G 4625 MYH7 ['AGCGGCCATCCCTGAGGGACAGTTCRTTG (p.Ile736Val) ATAGCAGGAAGGGGGCAGAGAA']

4407 NM_000257.3(MYH7):c.2681A>G 4625 MYH7 ['CTCCCCTCTGTTCCTCACCTTCAGGDACAA (p.Glu894Gly) GACAACCTGGCAGATGCTGAG]

4408 NM_000260.3 (MY07 A) :c .1344- 4647 MY07A ['CCTTACCCCATCCCTGTGCCCCTGCRGCTT 2A>G TGAGCAGCTCTGCATCAACTT']

4409 NM_000260.3(MYO7A):c.6029A> 4647 MY07A ['GTGCCAGGGAAGGATCCCATGGCCGRTTC G (p.Asp2010Gly) CATCTTCCACTATTACCAGGTG]

4410 NM_000260.3(MYO7A):c.6439- 4647 MY07A ['CTCTCTATGCCCTTTCTGCTCCCCCRGGAT 2A>G ATCCTCACCACTCATCCCTTC]

4411 M_000441.1 (SLC26 A4) :c . -3 - -1 ['CCCTCCTCGCTGTCCTCTGGCTCGCRGGTC 2A>G ATGGCAGCGCCAGGCGGCAGG]

4412 M_000441.1 (SLC26 A4) :c.1149+3 5172 SLC26A4 ['ATTACACCATCGATGGGAACCAGGTDTGG A>G GTGCCCTTTTGCTGAACTGGTT']

4413 NM_000551.3(VHL):c.467A>G 7428 VHL ['GATTTGGTTTTTGCCCTTCCAGTGTRTACTC (p.Tyrl56Cys) TGAAAGAGCGATGCCTCCAG]

4414 NM_002294.2(LAMP2):c.65-2A>G 3920 LAMP2 ['AAATATTATTTTTTTAAATGAATCCRGGAG

CTGTGCGGTCTTATGCATTGG]

4415 M_004004.5(GJB2):c.1 A>G 2706 GJB2 ['CAGAGCAAACCGCCCAGAGTAGAAGRTGG (p.MetlVal) ATTGGGGCACGCTGCAGACGAT']

4416 M_004004.5(GJB2):c.617A>G 2706 GJB2 ['GTGTCTGGAATTTGCATCCTGCTGARTGTC (p.Asn206Ser) ACTGAATTGTGTTATTTGCTA']

4417 NM_033360.3(KRAS):c.l82A>G 3845 KRAS ['TTGGATATTCTCGACACAGCAGGTCNAGA (p.Gln61Arg) GGAGTACAGTGCAATGAGGGAC]

4418 NM_006218.2(PIK3CA):c.l637A> 5290 PIK3CA ['GATCCTCTCTCTGAAATCACTGAGCRGGAG G (p.Gln546Arg) AAAGATTTTCTATGGAGTCAC]

4419 NM_006218.2(PIK3CA):c.3073A> 5290 PIK3CA ['TGATGACATTGCATACATTCGAAAGRCCCT G (p.Thrl025Ala) AGCCTTAGATAAAACTGAGCA']

4420 NM_032119.3(ADGRVl):c.14973- 84059 ADGRV1 ['TTCTTCATGATTTAATTTTTTTCCCRGATCA 2A>G GGTTTCATTGTTGCTGAAAT']

4421 NM_033056.3(PCDH15):c.l998- 65217 PCDH15 ['TTATTTGTTTGTTTGTTTTGTCACTRGCACG 2A>G GGGATTCTAACCTTAGGGAA']

4422 NM_138691.2(TMCl):c.l763+3A> 11753 TMC1 ['ATCTTCAACCAAGGCATGATCTGGTRGGCC G 1 AGCTGTTGGACAGCTTATCAC]

4423 NM_206933.2(USH2A):c. l2067- 7399 USH2A ['CAACTTAACCTGTTAATTTTCTTACRGGGA 2A>G ACAAGCCATCAAGCCCACCTG]

4424 NM_206933.2(USH2A):c. l2295- 7399 USH2A ['CCCGTCACTGAAGATGTTGTATGTCYACAG 2A>G AAGGACAGAAGCAAAAGGGAT']

4425 NM_206933.2(USH2A):c. l841- 7399 USH2A ['ATAATGCATAACCTTTCCCTGATGCRGGAA 2A>G GGAACTGTGAGCTGTGCAAGG]

4426 NM_206933.2(USH2A):c.8559- 7399 USH2A ['GATGTTCCTGCTTGTCTTTTGCTTTRGATAT 2A>G GAGCTTCTGAGACGTAAAAT']

4427 NM_032415.5(CARDl l):c.401A> 84433 CARD11 ['GGCCTCACGCACTTCCTGATGAACGRGGTC G (p.Glul34Gly) ATCAAGCTGCAGCAGCAGATG]

4428 NM_000548.3(TSC2):c.226-2A>G 7249 TSC2 ['CACCGCTGTCCCCTCTGCTGGTGACRGCAC

GCAGTGGAAGCACTCTGGAAG]

4429 NM_000548.3(TSC2):c. l444-2A>G 7249 TSC2 ['TCATTGGCCTCCCTTGTGCCTGTGCRGGAG

GAGCTGATTAACTCAGTGGTC]

4430 NM_000548.3(TSC2):c.2546-2A>G 7249 TSC2 ['CCCTGACCACCCTCTCCATTACCGCDGCTC

TGGCCAGGCTGCCGCACCTCT']

4431 NM_130466.3(UBE3B):c.545- 89910 UBE3B ['TTTGTTCTCACTGTTTTCTTTCTTTRGGTGA 2A>G AAGTCTTCGACCAGCGATGA']

4432 NM_005430.3(WNTl):c.624+4A> 7471 WNT1 ['CAACAACGAGGCAGGCCGTACGGTGRGCT G TTGAGAGGCTCCGCACCCTAAG]

4433 NM_001893.4(CSNKlD):c.l37A> 1453 CSNK1D ['AAGCTTGAATGTGTCAAAACCAAACRCCC G (p.His46Arg) TCAGCTCCACATTGAGAGCAAA']

4434 NM_018972.2(GDAPl):c.368A>G 54332 GDAP1 ['AGCATGTATTACCCACGGGTACAACRTTAC (p.Hisl23Arg) CGAGAGCTGCTTGACTCCTTG]

4435 NM_032237.4(POMK):c.773A>G 84197 POMK ['CATGGGGATTTCGTGGCTCCAGAGCRACT (p.Gln258Arg) GTGGCCCTATGGAGAGGACGTG]

4436 NM_201647.2(STAMBP):c.l25A> 10617 STAMBP ['CGTCGGTACTTCCGCTCTGGAGTTGRGATT G (p.Glu42Gly) ATCCGAATGGCATCCATTTAC]

4437 NM_001946.3(DUSP6):c.566A>G 1848 DUSP6 ['ACTACCATCCGAGTCTGTTGCACTAYTGGG (p.Asnl89Ser) GTCTCGGTCAAGGTCAGACTC]

4438 NM_003867.3(FGF17):c.560A>G 8822 FGF17 ['TACCAAGGCCAGCTGCCCTTCCCCARCCAC (p.Asnl87Ser) GCCGAGAAGCAGAAGCAGTTC]

4439 NM_013281.3(FLRT3):c.l016A>G -1 ['GGGCTCATGTGCCAAGCCCCAGAAARGGT (p.Lys339Arg) TCGTGGGATGGCTATTAAGGAT']

4440 NM_015560.2(OPAl):c.l l46A>G 4976 OPA1 ['TTTTTATTTTTCCTGAGTAGACCATRTCCTT (p.Ile382Met) AAATGTAAAAGGCCCTGGAC]

4441 NM_030964.3(SPRY4):c.530A>G 81848 SPRY4 ['CCGGCGGTCCCACCCGAGCTGGACARGCA (p.Lysl77Arg) CTTCTTGCTGTGCGAGGCCTGT']

4442 NM_002972.3(SBFl):c. l249A>G 6305 SBF1 ['AAGGCCATGCCCTCCAGCACCTTCAYCAG (p.Met417Val) GAAATCGTCCTCTACCAGCCCA]

4443 NM_002972.3(SBFl):c.4768A>G 6305 SBF1 ['TACATGTAATTGTGGAACACAGGCGYCCT (p.Thrl590Ala) CTTGCTCAGCCGGTCCACATAC]

4444 NM_006876.2(B4GATl):c.l l68A> 11041 B4GAT1 ['GTTCCATCCCCAAAAGGAGGCTGAARATC G (p.Asn390Asp) AGCACAATAAGATCCTATATCG]

4445 NM_000059.3(BRCA2):c.517- 675 BRCA2 ['AAAATAAACTATTTTCTTTCCTCCCVGGGT 2A>G CGTCAGACACCAAAACATATT']

4446 NM_000059.3(BRCA2):c.6938- 675 BRCA2 ['ATGTAATATAAAATAATTGTTTCCTRGGCA 2A>G CAATAAAAGATCGAAGATTGT']

4447 NM_000059.3(BRCA2):c.7008- 675 BRCA2 ['AACTTATATATTTTCTCCCCATTGCDGCAC 2A>G AACTAAGGAACGTCAAGAGAT']

4448 NM_000059.3(BRCA2):c.7806- 675 BRCA2 ['GATAATATTCTACTTTTATTTGTTCRGGGC 2A>G TCTGTGTGACACTCCAGGTGT']

4449 NM_000059.3(BRCA2):c.8754+4A 675 BRCA2 ['AGCAGACCCAGCTTACCTTGAGGTGRGAG >G AGTAAGAGGACATATAATGAGG]

4450 NM_000059.3(BRCA2):c.9118- 675 BRCA2 ['GTTGAATTTTTGTTTTGTTTTCTGTRGGTTT 2A>G CAGATGAAATTTTATTTCAG]

4451 NM_000059.3(BRCA2):c.9649- 675 BRCA2 ['TAGGCTACGTTTTCATTTTTTTATCRGATGT

2A>G CTTCTCCTAATTGTGAGATA]

NM_000218.2(KCNQl):c.l070A> 3784 KCNQ1 []

G (p.Gln357Arg)

4452 NM_000218.2(KCNQl):c.l085A> 3784 KCNQ1 ['AAGGTGCAGCAGAAGCAGAGGCAGARGC G (p.Lys362Arg) ACTTCAACCGGCAGATCCCGGCG]

4453 NM_000218.2(KCNQl):c.l576A> 3784 KCNQ1 ['TCGACGCATGCAGTACTTTGTGGCCVAGA G (p.Lys526Glu) AGAAATTCCAGGTAAGCCCTGT']

NM_000218.2(KCNQl):c.l756A> 3784 KCNQ1 []

G (p.Asn586Asp)

4454 NM_000218.2(KCNQl):c.332A>G 3784 KCNQ1 ['CGCACCCACGTCCAGGGCCGCGTCTRCAA (p.Tyrl l lCys) CTTCCTCGAGCGTCCCACCGGC]

NM_000218.2(KCNQl):c.344A>G 3784 KCNQ1 []

(p.Glul l5Gly)

4455 NM_000218.2(KCNQl):c.773A>G 3784 KCNQ1 ['CTCCTGGGCTCCGTGGTCTTCATCCVCCGC (p.His258Arg) CAGGTGGGTGGCCCGGGTTAG]

4456 NM_000218.2(KCNQl):c.944A>G 3784 KCNQ1 ['CAGGTCACAGTCACCACCATCGGCTNTGG (p.Tyr315Cys) GGACAAGGTGCCCCAGACGTGG]

NM_000218.2(KCNQl):c.964A>G 3784 KCNQ1 []

(p.Thr322Ala)

4457 NM_000492.3 (CFTR) : c.1393 - 1080 CFTR ['CCTAATAATGATGGGTTTTATTTCCRGACT 2A>G TCACTTCTAATGGTGATTATG]

4458 NM_000492.3(CFTR):c.1766+3 A> 1080 CFTR ['ACAGAAAAAGAAATATTTGAAAGGTVTGT G TCTTTGAATACCTTACTTATAA']

4459 NM_000492.3(CFTR):c. lA>G 1080 CFTR ['CAGGGACCCCAGCGCCCGAGAGACCRTGC (p.MetlVal) AGAGGTCGCCTCTGGAAAAGGC]

4460 NM_000492.3(CFTR):c.2989- 1080 CFTR ['ACCAACATGTTTTCTTTGATCTTACDGTTG 2A>G TTATTAATTGTGATTGGAGCT']

4461 NM_000492.3(CFTR):c.579+3A>G 1080 CFTR ['ACAACCTGAACAAATTTGATGAAGTNTGT

ACCTATTGATTTAATCTTTTAG]

4462 NM_007294.3(BRCAl):c.l22A>G 672 BRCA1 ['GAACCTGTCTCCACAAAGTGTGACCRCAT (p.His41Arg) ATTTTGCAAGTAAGTTTGAATG]

4463 NM_007294.3 (BRCA1 ) :c .1 A>G 672 BRCA1 ['TTAAAGTTCATTGGAACAGAAAGAARTGG (p.MetlVal) ATTTATCTGCTCTTCGCGTTGA']

4464 NM_007294.3(BRCAl):c.212+3A> 672 BRCA1 ['TGTAAGAATGATATAACCAAAAGGTRTAT G AATTTGGTAATGATGCTAGGTT']

4465 NM_007294.3(BRCAl):c.4097- 672 BRCA1 ['TCTGAACCTCTGTTTTTGTTATTTAVGGTG 2A>G AAGCAGCATCTGGGTGTGAGA']

4466 NM_007294.3(BRCAl):c.4485- 672 BRCA1 ['GTTTTCTCCTTCCATTTATCTTTCTRGGTCA

2A>G TCCCCTTCTAAATGCCCATC]

4467 NM_007294.3(BRCAl):c.4987- 672 BRCA1 ['ATAATGGAATATTTGATTTAATTTCRGATG 2A>G CTCGTGTACAAGTTTGCCAGA]

4468 NM_007294.3(BRCAl):c.5053A> 672 BRCA1 ['AACTAATCTAATTACTGAAGAGACTRCTCA G (p.Thrl685Ala) TGTTGTTATGAAAACAGGTAT']

4469 NM_007294.3(BRCAl):c.5407- 672 BRCA1 ['AATGCTCTTTCCTTCCTGGGGATCCDGGGT 2A>G GTCCACCCAATTGTGGTTGTG]

4470 NM_000540.2(RYRl):c.97A>G 6261 RYR1 ['CGCTACCGTGCTCAAGGAGCAGCTCRAGC (p.Lys33Glu) TCTGCCTGGCCGCCGAGGGCTT']

4471 NM_015250.3(BICD2):c.2321A>G 23299 BICD2 ['CGGCAGCTGGCGGCTGCTGAGGACGRGAA (p.Glu774Gly) GAAGACGCTGAACTCGCTGCTG]

4472 NM_006012.2(CLPP):c.270+4A>G 8192 CLPP ['CATCGTGTGCGTCATGGGCCCGGTGRGCG

CCCCGCGCCGGGACCCTCCCCA]

4473 NM_004656.3(BAPl):c.277A>G 8314 BAP1 ['AGGAGCACGCTCAGCAAGGCATGAGHTGC (p.Thr93Ala) ACAAGAGTTGGGTATCAGCTGT']

4474 NM_004315.4(ASAHl):c.965+4A> 427 ASAH1 ['AGGAATCATTGGATGTATATGAGTARGTA G GGTTTGTTAAAGCAAAAGAAGT']

4475 NM_000100.3(CSTB):c. l69-2A>G 1476 CSTB ['GCTTCGCTCACTCCGCTCTCTTCCCRGGTG

CACGTCGGCGACGAGGACTTC]

4476 NM_015268.3(DNAJC13):c.2564A 23317 DNAJC13 ['TTAAAATCTAGGTATGAATTTTTCARTGAG >G (p.Asn855Ser) CTTTATCATCGCTTCTTGCTC]

4477 NM_001003722.1(GLEl):c.433- 2733 GLE1 ['CTTAAAAAAAAAAAAAAAAAAAAAARCCT 10A>G TTTCAGGAGGGCCTGAGGCTAT']

4478 NM_001142519.1(FAMl llA):c. l5 63901 FAM111A ['TTCCAGAAAATAGTTCACAACCCTGDTGTG 83A>G (p.Asp528Gly) ATTACCTATGACACTGAATTT']

4479 NM_001142519.1(FAMl llA):c. lO 63901 FAM111A ['GCATAGAACAACGTTTGGGAAAGTARCAA 12A>G (p.Thr338Ala) AAAATTCTTCTTCGATTAAAGT']

4480 NM_001927.3(DES):c.l289-2A>G 1674 DES ['CTGAGTGTGCGATGGACCCTGTTACRGAA

ACCAGCCCTGAGCAAAGGGGTT']

4481 NM_014795.3(ZEB2):c.3134A>G 9839 ZEB2 ['AAACACAAGCACCACCTTATCGAGCRCTC (p.Hisl045Arg) AAGGCTTCACTCGGGCGAGAAG]

4482 NM_002163.2(IRF8):c.322A>G 3394 IRF8 ['CCAACTGGACATTTCCGAGCCATACRAAG (p.Lysl08Glu) TTTACCGAATTGTTCCTGAGGA']

4483 NM_002163.2(IRF8):c.238A>G 3394 IRF8 ['CAAAGCTGAACCAGCCACTTGGAAGRCGA (p.Thr80Ala) GGTTACGCTGTGCTTTGAATAA']

4484 NM_001287.5(CLCN7):c.296A>G 1186 CLCN7 ['TGTCCCGGCCTGCAGAGCTTGGACTRTGAC (p.Tyr99Cys) AACAGTGAGAACCAGCTGTTC]

4485 NM_001127217.2(SMAD9):c. l27A 4093 SMAD9 ['AGAGAAGGCAGTGGACTCTCTAGTGRAGA >G (p.Lys43Glu) AGTTAAAGAAGAAGAAGGGAGC]

4486 NM_002246.2(KCNK3):c.575A>G 3777 KCNK3 ['TGGACCTTCTTCCAGGCCTACTACTRCTGC (p.Tyrl92Cys) TTCATCACCCTCACCACCATC]

4487 NM_080605.3(B3GALT6):c.lA>G 12679 B3GALT6 ['CGCCACGCCCGCCGCAGCAGCTTCAYGGC (p.MetlVal) 2 GCCCGCGCCGGGCCGGCGGCCC]

4488 NM_080605.3(B3GALT6):c.l93A> 12679 B3GALT6 ['CGGCGCTCGGCGGCGCGGGGCGCGCYGGC G (p.Ser65Gly) 2 CACCAGCACTGCCAGGAAGGCG]

4489 NM_000388.3(CASR):c.85A>G 846 CASR ['CGGGCCAGACCAGCGAGCCCAAAAGRAGG (p.Lys29Glu) GGGACATTATCCTTGGGGGGCT']

4490 NM_003793.3(CTSF):c.962A>G 8722 CTSF ['GGGACCCTGCTCTCCCTCTCTGAACRGGGT (p.Gln321Arg) GAGCATCTCGCTCTACTCCTC]

4491 NM_003793.3(CTSF):c.692A>G 8722 CTSF ['GAGATCACTGAACTTGGTGACTCCAYACT (p.Tyr231Cys) GAGCTGTGCCACGGTCCAGGGC]

4492 NM_022114.3(PRDM16):c.2447A> 63976 PRDM16 ['GGCAGCCGGGCCCGTGCCAGCCAAARCGG G (p.Asn816Ser) CGGCGGGCGGGAGCCCCGCAAG]

4493 NM_173551.4(ANKS6):c.l322A> 20328 ANKS6 ['GGGCAGCACTGGGATGCTCCAGGGCYGTC G (p.Gln441Arg) 6 GGACCTTCGAGTGGGGCAGGGG]

4494 NM_005689.2(ABCB6):c.508A>G 10058 ABCB6 ['GAACTTGGCCCTGGTGTCTTGGAACRGCCC (p.Serl70Gly) ACAGTGGTGGTGGGCAAGGGC]

4495 NM_001070.4(TUBGl):c.275A>G 7283 TUBG1 ['AAGCTCTACAACCCAGAGAACATCTRCCT (p.Tyr92Cys) GTCGGAACATGGAGGAGGAGCT']

4496 NM_001613.2(ACTA2):c. l45A>G 59 ACTA2 ['ACCTTTTTAGGGGGTGATGGTGGGARTGG (p.Met49Val) GACAAAAAGACAGCTACGTGGG]

4497 NM_031157.2(HNRNPAl):c.956A 3178 HNRNPA1 ['AGCTACAATGATTTTGGGAATTACARCAAT >G (p.Asn319Ser) CAGTCTTCAAATTTTGGACCC]

4498 NM_020117.9(LARS):c.1118A>G 51520 LARS ['CTTAATAGTTAGCATTGGGAGAACAYAGA (p.Tyr373Cys) TCACCTTGTATGATGTTAAAGG]

4499 NM_001651.3(AQP5):c.367A>G 362 AQP5 ['CTAACCCGCTATCCCCTTGCAGCTCRACAA (p.Asnl23Asp) CAACACAACGCAGGGCCAGGC]

4500 m. l3637A>G 4540 MT-ND5 ['ATAATTCTTCTCACCCTAACAGGTCRACCT

CGCTTCCCCACCCTTACTAAC]

4501 NM_000081.3 (LYST) : c.10127 A>G 1130 LYST ['GGGAAGGCTTCTGTTCAAGCGATCARTGTT (p.Asn3376Ser) TTTCATCCTGCTGTAAGTGAC]

4502 NM_000142.4(FGFR3):c.2421A>G 2261 FGFR3 ['CCAGCAGTGGGGGCTCGCGGACGTGNAGG (p.Ter807Trp) GCCACTGGTCCCCAACAATGTG]

4503 NM_000207.2(INS):c.*59A>G -1 ['TCCTGCACCGAGAGAGATGGAATAARGCC

CTTGAACCAGCCCTGCTGTGCC]

4504 NM_000370.3 (TTP A) : c.191 A>G 7274 TTPA ['CTGCGCGCCCGGGATTTCGATCTGGRCCTG (p.Asp64Gly) GCCTGGCGGGTAAGCGTGCGT']

4505 NM_001006657.1(WDR35):c.2912 57539 WDR35 ['AAACCTTTACGTGTCAAGAAGCTCTRTGTA A>G (p.Tyr971Cys) CTGTCAGCCTTACTTATAGAG]

4506 NM_004595.4(SMS):c.443A>G 6611 SMS ['GTATATGACGAAGATTCACCTTATCRAAAT (p.Glnl48Arg) ATAAAAATTCTACACTCGAAG]

4507 NM_005259.2(MSTN):c.458A>G -1 ['AAAATACAATACAATAAAGTAGTAARGGC (p.Lysl53Arg) CCAACTATGGATATATTTGAGA]

4508 NM_000784.3(CYP27Al):c. l061A 1593 CYP27A1 ['TGGGCCCTGTACCACCTCTCAAAGGRCCCT >G (p.Asp354Gly) GAGATCCAGGAGGCCTTGCAC]

4509 NM_000784.3(CYP27Al):c.776A> 1593 CYP27A1 ['TCACTCTATGCCACCTTCCTCCCCARGTGG G (p.Lys259Arg) ACTCGCCCCGTGCTGCCTTTC]

4510 NM_000540.2(RYRl):c.l0100A>G 6261 RYRl ['ATCCCAACTATCGGGCGGCTGCGCARGAG (p.Lys3367Arg) GGCAGGGAAGGTGGTGTCCGAG]

4511 NM_000540.2(RYRl):c.l4572A>G 6261 RYRl ['CTACCTGTACACCGTGGTGGCCTTCRACTT (p.Asn4858Asp) CTTCCGCAAGTTCTACAACAA]

4512 NM_000540.2(RYRl):c.l4740A>G 6261 RYR1 ['CGCGGGTGACGAATACGAGCTCTACRGGG (p.Arg4914Gly) TGGTCTTCGACATCACCTTCTT']

4513 NM_000540.2(RYRl):c.l4591A>G 6261 RYR1 ['GCCTTCAACTTCTTCCGCAAGTTCTRCAAC (p.Tyr4864Cys) AAGAGCGAGGATGAGGATGAA']

4514 NM_002336.2(LRP6):c. l298A>G 4040 LRP6 ['GATCGAATAGAAGTGACAAGGCTCARTGG (p.Asn433Ser) GACCATGAGGAAGATCTTGATT']

4515 NM_001257235.1(ALG13):c.8A>G 79868 ALG13 ['GTTATAAACGAAAAGTTGATGAACARTCA (p.Asn3Ser) TCAGCTGGAACTGGCAAAGCAG]

4516 NM_001015879.1(AURKC):c.379- 6795 AURKC ['CAGGGTGACTTTTCTTTGCACCCACRGATA 2A>G ATAGAGGAGTTGGCAGATGCC]

4517 NM_012160.4(FBXL4):c.l694A>G 26235 FBXL4 ['AATTGTACCAGGTTACAGCAGCTGGRCAT (p.Asp565Gly) ATTAGGTAAGGTTACAATATAT']

4518 NM_020988.2(GNAOl):c.521A>G 2775 GNAOl ['GCCGACTACCAGCCCACCGAGCAGGRCAT (p.Aspl74Gly) CCTCCGAACCAGGGTCAAAACC]

4519 NM_001927.3 (DES) :c .1024 A>G 1674 DES ['GACCTGGGTTCCCCCTCTCCTGCAGRACGA (p.Asn342Asp) TTCCCTGATGAGGCAGATGCG]

4520 NM_001927.3(DES):c.l333A>G 1674 DES ['GGGTTCTGAGGTCCATACCAAGAAGRCGG (p.Thr445Ala) TGATGATCAAGACCATCGAGAC]

4521 NM_001927.3(DES):c.735+3A>G 1674 DES ['TCCTTAAGAAAGTGCATGAAGAGGTRTAC

CTTGGCCCCTCTTCCTGGGGTC]

4522 NM_002055.4(GFAP):c.l097A>G 2670 GFAP ['GCCCTGGACATCGAGATCGCCACCTRCAG (p.Tyr366Cys) GAAGCTGCTAGAGGGCGAGGAG]

4523 NM_002055.4(GFAP):c.l l l2A>G 2670 GFAP ['ATCGCCACCTACAGGAAGCTGCTAGDGGG (p.Glu371Gly) CGAGGAGAACCGGTGAGCCCTC]

4524 NM_002055.4(GFAP):c.l l21A>G 2670 GFAP ['TACAGGAAGCTGCTAGAGGGCGAGGRGAA (p.Glu374Gly) CCGGTGAGCCCTCATCACAGCC]

4525 NM_002055.4(GFAP):c.230A>G 2670 GFAP ['GAGCGGGCAGAGATGATGGAGCTCARTGA (p.Asn77Ser) CCGCTTTGCCAGCTACATCGAG]

4526 NM_002055.4(GFAP):c.770A>G 2670 GFAP ['AACATGCATGAAGCCGAAGAGTGGTRCCG (p.Tyr257Cys) CTCCAAGGTAGCCCTGCCTGTG]

4527 NM_002055.4(GFAP):c.835A>G 2670 GFAP ['CAACGCGGAGCTGCTCCGCCAGGCCRAGC (p.Lys279Glu) ACGAAGCCAACGACTACCGGCG]

4528 NM_005554.3(KRT6A):c.511A>G 3853 KRT6A ['GGAGCGTGAACAGATCAAGACCCTCDACA (p.Asnl71Asp) ACAAGTTTGCCTCCTTCATCGA]

4529 NM_005554.3(KRT6A):c.512A>G 3853 KRT6A ['GAGCGTGAACAGATCAAGACCCTCAVCAA (p.Asnl71Ser) CAAGTTTGCCTCCTTCATCGAC]

4530 NM_005557.3(KRT16):c.373A>G 3868 KRT16 ['TGAGAAGGTGACCATGCAGAACCTCRATG (p.Asnl25Asp) ACCGCCTGGCCTCCTACCTGGA']

4531 NM_170707.3(LMNA):c.640- 4000 LMNA ['TTTTGGTTTCTGTGTCCTTCCTCCAVCCCTT 10A>G CCAGGAGCTGCGTGAGACCA']

NM_000218.2(KCNQl):c.l061A> 3784 KCNQ1 []

G (p.Lys354Arg)

NM_000218.2(KCNQl):c.l l38A> 3784 KCNQ1 [] G (p.Arg380Gly)

NM_000218.2(KCNQl):c.l l93A> 3784 KCNQ1 []

G (p.Lys398Arg)

NM_000218.2(KCNQl):c.l640A> 3784 KCNQ1 []

G (p.Gln547Arg)

NM_000218.2(KCNQl):c.l669A> 3784 KCNQ1 []

G (p.Lys557Glu)

NM_000218.2(KCNQl):c.l705A> 3784 KCNQ1 []

G (p.Lys569Glu)

NM_000218.2(KCNQl):c.l793A> 3784 KCNQ1 []

G (p.Lys598Arg)

NM_000218.2(KCNQl):c.430A>G 3784 KCNQ1 []

(p.Thrl44Ala)

NM_000218.2(KCNQl):c.440A>G 3784 KCNQ1 []

(p.Glnl47Arg)

NM_000218.2(KCNQl):c.548A>G 3784 KCNQ1 []

(p.Lysl83Arg)

4532 NM_000218.2(KCNQl):c.592A>G 3784 KCNQ1 ['GCGGCTGCGCTTTGCCCGGAAGCCCRTTTC (p.Ilel98Val) CATCATCGGTGAGTCATGCCT']

4533 NM_000218.2(KCNQl):c.652A>G 3784 KCNQ1 ['CATGGTGGTCCTCTGCGTGGGCTCCRAGGG (p.Lys218Glu) GCAGGTGTTTGCCACGTCGGC]

4534 NM_000218.2(KCNQl):c.820A>G 3784 KCNQ1 ['CCTGTACATCGGCTTCCTGGGCCTCRTCTT (p.Ile274Val) CTCCTCGTACTTTGTGTACCT']

NM_000218.2(KCNQl):c.842A>G 3784 KCNQ1 []

(p.Tyr281Cys)

NM_000218.2(KCNQl):c.931A>G 3784 KCNQ1 []

(p.Thr311Ala)

NM_000218.2(KCNQl):c.950A>G 3784 KCNQ1 []

(p.Asp317Gly)

NM_000238.3(KCNH2):c.l205A> 3757 KCNH2 []

G (p.His402Arg)

NM_000238.3(KCNH2):c.l259A> 3757 KCNH2 []

G (p.Tyr420Cys)

4535 NM_000238.3(KCNH2):c.l280A> 3757 KCNH2 ['ATCTACACGGCTGTCTTCACACCCTVCTCG G (p.Tyr427Cys) GCTGCCTTCCTGCTGAAGGAG]

NM_000238.3(KCNH2):c.l28A>G 3757 KCNH2 []

(p.Tyr43Cys)

NM_000238.3 (KCNH2) :c .1424 A> 3757 KCNH2 []

G (p.Tyr475Cys)

4536 NM_000238.3(KCNH2):c.l478A> 3757 KCNH2 ['CACCCCGGCCGCATCGCCGTCCACTNCTTC G (p.Tyr493Cys) AAGGGCTGGTTCCTCATCGAC]

NM_000238.3(KCNH2):c.l502A> 3757 KCNH2 []

G (p.Asp501Gly)

4537 NM_000238.3(KCNH2):c.l685A> 3757 KCNH2 ['ATGTGCACCTTTGCGCTCATCGCGCVCTGG G (p.His562Arg) CTAGCCTGCATCTGGTACGCC]

4538 NM_000238.3 (KCNH2) :c .1711 A> 3757 KCNH2 ['CTGGCTAGCCTGCATCTGGTACGCCVTCGG G (p.Ile571Val) CAACATGGAGCAGCCACACAT']

4539 NM_000238.3 (KCNH2) :c .1720 A> 3757 KCNH2 ['CTGCATCTGGTACGCCATCGGCAACVTGG G (p.Met574Val) AGCAGCCACACATGGACTCACG]

NM_000238.3 (KCNH2) :c .1724 A> 3757 KCNH2 []

G (p.Glu575Gly)

4540 NM_000238.3(KCNH2):c.l73A>G 3757 KCNH2 ['GAGCTGTGCGGCTACTCGCGGGCCGVGGT (p.Glu58Gly) GATGCAGCGACCCTGCACCTGC]

NM_000238.3 (KCNH2) :c .1747 A> 3757 KCNH2 []

G (p.Ile583Val)

NM_000238.3 (KCNH2) :c .1762 A> 3757 KCNH2 []

G (p.Asn588Asp)

NM_000238.3 (KCNH2) :c .1777 A> 3757 KCNH2 []

G (p.Ile593Val)

NM_000238.3(KCNH2):c.l783A> 3757 KCNH2 []

G (p.Lys595Glu)

NM_000238.3(KCNH2):c.l790A> 3757 KCNH2 []

G (p.Tyr597Cys)

NM_000238.3 (KCNH2) :c .1826 A> 3757 KCNH2 []

G (p.Asp609Gly)

NM_000238.3 (KCNH2) :c .1847 A> 3757 KCNH2 []

G (p.Tyr616Cys)

NM_000238.3(KCNH2):c.l885A> 3757 KCNH2 []

G (p.Asn629Asp)

4541 NM_000238.3(KCNH2):c.l886A> 3757 KCNH2 ['AGCCTCACCAGTGTGGGCTTCGGCANCGT G (p.Asn629Ser) CTCTCCCAACACCAACTCAGAG]

NM_000238.3(KCNH2):c.l897A> 3757 KCNH2 []

G (p.Asn633Asp)

4542 NM_000238.3(KCNH2):c.l898A> 3757 KCNH2 ['GTGGGCTTCGGCAACGTCTCTCCCADCACC G (p.Asn633Ser) AACTCAGAGAAGATCTTCTCC]

NM_000238.3(KCNH2):c.l903A> 3757 KCNH2 []

G (p.Asn635Asp)

NM_000238.3 (KCNH2) :c .1910 A> 3757 KCNH2 []

G (p.Glu637Gly)

NM_000238.3 (KCNH2) :c .1912 A> 3757 KCNH2 []

G (p.Lys638Glu)

4543 NM_000238.3(KCNH2):c.l933A> 3757 KCNH2 ['AGAGAAGATCTTCTCCATCTGCGTCDTGCT G (p.Met645Val) CATTGGCTGTGAGTGTGCCCA]

NM_000238.3(KCNH2):c.209A>G 3757 KCNH2 []

(p.His70Arg)

4544 NM_000238.3(KCNH2):c.2131A> 3757 KCNH2 ['GCACGCCTGGTCCTACACCAACGGCRTCG G (p.Ile711Val) ACATGAACGCGGTGAGGCCACC]

NM_000238.3(KCNH2):c.2266A> 3757 KCNH2 [] G (p.Met756Val)

NM_000238.3(KCNH2):c.2510A> 3757 KCNH2 []

G (p.Asp837Gly)

NM_000238.3(KCNH2):c.2591A> 3757 KCNH2 []

G (p.Asp864Gly)

NM_000238.3(KCNH2):c.286A>G 3757 KCNH2 []

(p.Ile96Val)

4545 NM_000238.3 (KCNH2) :c .301 A>G 3757 KCNH2 ['CAAAGTGGAAATCGCCTTCTACCGGDAAG (p.LyslOlGlu) ATGGTAGGAGCGGGCCGGGGCG]

4546 NM_000238.3 (KCNH2) :c .3118 A> 3757 KCNH2 ['TCGGCGGCCCCGGGGCGACGTGGAGRGCA G (p.Serl040Gly) GGCTGGATGCCCTCCAGCGCCA]

NM_000238.3(KCNH2):c.3233A> 3757 KCNH2 []

G (p.Tyrl078Cys)

NM_000238.3(KCNH2):c.3343A> 3757 KCNH2 []

G (p.Metl l l5Val)

NM_000238.3(KCNH2):c.652A>G 3757 KCNH2 []

(p.Met218Val)

NM_000238.3 (KCNH2) :c .82 A>G 3757 KCNH2 []

(p.Lys28Glu)

NM_000891.2(KCNJ2):c.220A>G 3759 KCNJ2 []

(p.Thr74Ala)

NM_000891.2(KCNJ2):c.223A>G 3759 KCNJ2 []

(p.Thr75Ala)

NM_000891.2(KCNJ2):c.233A>G 3759 KCNJ2 []

(p.Asp78Gly)

NM_000891.2(KCNJ2):c.574A>G 3759 KCNJ2 []

(p.Thrl92Ala)

4547 NM_000891.2(KCNJ2):c.913A>G 3759 KCNJ2 ['CATACTGGAAGGCATGGTGGAAGCCVCTG (p.Thr305Ala) CCATGACGACACAGTGCCGTAG]

NM_172201.1 (KCNE2) :c.269 A>G 9992 KCNE2 []

(p.Glu90Gly)

4548 NM_172201.1(KCNE2):c.281A>G 9992 KCNE2 ['CAGTACATTGTAGAGGACTGGCAGGRAAA (p.Glu94Gly) GTACAAGAGCCAAATCTTGAAT']

NM_000335.4(SCN5A):c. l217A>G 6331 SCN5A []

(p.Asn406Ser)

NM_000335.4(SCN5A):c. l502A>G 6331 SCN5A []

(p.Asp501Gly)

NM_000335.4(SCN5A):c.2249A>G 6331 SCN5A []

(p.Gln750Arg)

NM_198056.2(SCN5A):c.2527A>G 6331 SCN5A []

(p.Thr843Ala)

NM_000335.4(SCN5A):c.2780A>G 6331 SCN5A []

(p.Asn927Ser)

NM_000335.4(SCN5A):c.3164A>G 6331 SCN5A [] (p.Aspl055Gly)

NM_000335.4(SCN5A):c.343A>G 6331 SCN5A []

(p.Serll5Gly)

NM_000335.4(SCN5A):c.3755A>G 6331 SCN5A []

(p.Glul252Gly)

4549 NM_000335.4(SCN5A):c.376A>G 6331 SCN5A ['AAAGGATATGAGTGAACCAGAATCTYCAC (p.Lysl26Glu) AGCCGCTCTCCGGATGGGGTGG]

4550 NM_198056.2(SCN5A):c.4000A>G 6331 SCN5A ['TGCCCTGGTGGGCGCCATCCCGTCCRTCAT (p.Ilel334Val) GAACGTCCTCCTCGTCTGCCT']

NM_000335.4(SCN5A):c.4223A>G 6331 SCN5A []

(p.Tyrl408Cys)

NM_000335.4(SCN5A):c.4252A>G 6331 SCN5A []

(p.Lysl418Glu)

NM_000335.4(SCN5A):c.4291A>G 6331 SCN5A []

(p.Argl431Gly)

NM_198056.2(SCN5A):c.4346A>G 6331 SCN5A []

(p.Tyrl449Cys)

NM_000335.4(SCN5A):c.4412A>G 6331 SCN5A []

(p.Asnl471Ser)

4551 NM_198056.2(SCN5A):c.4478A>G 6331 SCN5A ['ATCTTCATGACAGAGGAGCAGAAGARGTA (p.Lysl493Arg) CTACAATGCCATGAAGAAGCTG]

NM_000335.4(SCN5A):c.4489A>G 6331 SCN5A []

(p.Metl497Val)

NM_000335.4(SCN5A):c.4577A>G 6331 SCN5A []

(p.Lysl526Arg)

4552 NM_198056.2(SCN5A):c.4978A>G 6331 SCN5A ['GATGTCCCTGCCTGCCCTCTTCAACRTCGG (p.Ilel660Val) GCTGCTGCTCTTCCTCGTCAT']

NM_000335.4(SCN5A):c.5138A>G 6331 SCN5A []

(p.Aspl713Gly)

NM_000335.4(SCN5A):c.5161A>G 6331 SCN5A []

(p.Asnl721Asp)

NM_000335.4(SCN5A):c.5297A>G 6331 SCN5A []

(p.Tyrl766Cys)

NM_198056.2(SCN5A):c.5302A>G 6331 SCN5A []

(p.Ilel768Val)

NM_000335.4(SCN5A):c.5317A>G 6331 SCN5A []

(p.Asnl773Asp)

NM_000335.4(SCN5A):c.5318A>G 6331 SCN5A []

(p.Asnl773Ser)

NM_000335.4(SCN5A):c.5366A>G 6331 SCN5A []

(p.Aspl789Gly)

NM_000335.4(SCN5A):c.5402A>G 6331 SCN5A []

(p.Aspl801Gly)

NM_000335.4(SCN5A):c.5513A>G 6331 SCN5A [] (p.Aspl838Gly)

NM_198056.2(SCN5A):c.5726A>G 6331 SCN5A []

(p.Glnl909Arg)

4553 NM_000335.4(SCN5A):c.688A>G 6331 SCN5A ['CCGAGTCCTCCGGGCCCTGAAAACTRTATC (p.Ile230Val) AGTCATTTCAGGTGAAAATCA]

NM_000335.4(SCN5A):c.715A>G 6331 SCN5A []

(p.Ile239Val)

NM_000335.4(SCN5A):c.89A>G 6331 SCN5A []

(p.Glu30Gly)

4554 NM_000383.3(AIRE):c.254A>G 326 AIRE ['TTCTGGAGGGTGCTGTTCAAGGACTRCAAC (p.Tyr85Cys) CTGGAGCGCTATGGCCGGCTG]

4555 NM_006920.4(SCNlA):c. l876A>G 6323 SCN1A ['ACGCAACAGCAACCTGAGTCAGACCRGTA (p.Ser626Gly) GGTCATCCCGGATGCTGGCAGT']

4556 NM_006920.4(SCNlA):c.4352A>G -1 ['GAAGAAAGTCTGTACATGTATCTTTRCTTT (p.Tyrl451Cys) GTTATTTTCATCATCTTTGGG]

4557 NM_000165.4(GJAl):c.617A>G 2697 GJA1 ['TGTTTCCTCTCTCGCCCCACGGAGARAACC (p.Lys206Arg) ATCTTCATCATCTTCATGCTG]

4558 NM_000833.4(GRIN2A):c.l l23- 2903 GRIN2A ['AGCTGTGTCTTTGTGTTTGTGCTGCRGGTG 2A>G GGCAAGTGGGAGAACCATACG]

4559 NC_000007.14:g.62535490A>G -1 ['GGAGAGTTTTGAGGCCTGTGGTTGARATG

GAAATATCTTCACAGAAAAACT']

4560 NM_004595.4(SMS):c.983A>G 6611 SMS ['AATCTGACAGAAGCACTGTCGCTCTVTGA (p.Tyr328Cys) AGAACAGCTGGGGCGCCTGTAT']

4561 NM_001256864.1(DNAJC6):c.801- 9829 DNAJC6 ['CAAGAGAGTGCCAACCTTCTGTTTCRGATA 2A>G CCTGGGCTATATGTGTGACCT']

4562 NM_001204316.1(PRLR):c.635A> 5618 PRLR ['GTCCAGGTTCGCTGCAAACCAGACCRTGG G (p.His212Arg) ATACTGGAGTGCATGGAGTCCA']

4563 NM_012243.2(SLC35A3):c.886A> 23443 SLC35A3 ['TTGGCTTCAAGATTTTGTGCCAACCRGGTA G (p.Ser296Gly) AAATGTTCTTTTCTATTTTTT']

4564 NM_000179.2(MSH6):c.3439- 2956 MSH6 ['AAAGACCTTTTCCTCCCTCATTCACRGGCT 2A>G GGCTTATTAGCTGTAATGGCC]

4565 NM_000249.3(MLHl):c.l l3A>G 4292 MLH1 ['AATGCTATCAAAGAGATGATTGAGARCTG (p.Asn38Ser) GTACGGAGGGAGTCGAGCCGGG]

4566 NM_000249.3(MLHl):c.l22A>G 4292 MLH1 ['TTTTCTGTTTGATTTGCCAGTTTAGRTGCA (p.Asp41Gly) AAATCCACAAGTATTCAAGTG]

4567 NM_000249.3(MLHl):c.l559- 4292 MLH1 ['TTTTTGGTTTTATTTTTTGTTTTGCNGTTCT 2A>G CCGGGAGATGTTGCATAACC]

4568 NM_000249.3(MLHl):c.l990- 4292 MLH1 ['TTGAGGTATTGAATTTCTTTGGACCRGGTG 2A>G AATTGGGACGAAGAAAAGGAA]

4569 NM_000249.3(MLHl):c.208-2A>G 4292 MLH1 ['TTTACTCATCTTTTTGGTATCTAACVGAAA

GAAGATCTGGATATTGTATGT']

4570 NM_000249.3(MLHl):c.544A>G 4292 MLH1 ['TGGGAAAATTTTGGAAGTTGTTGGCRGGT (p.Argl82Gly) ACAGTCCAAAATCTGGGAGTGG]

4571 NM_000249.3(MLHl):c.545+3A> 4292 MLH1 ['AAAATTTTGGAAGTTGTTGGCAGGTRCAGT G CCAAAATCTGGGAGTGGGTCT']

4572 NM_000249.3(MLHl):c.546-2A>G 4292 MLH1 ['TCTTACTCTTTTGTTTTTCTTTTCCVGGTAT

TCAGTACACAATGCAGGCAT']

4573 NM_000249.3(MLHl):c.589-2A>G 4292 MLH1 ['TTGTGTCTTCTGCTGTTTGTTTATCRGCAAG

GAGAGACAGTAGCTGATGTT']

4574 NM_000249.3(MLHl):c.677+3A> 4292 MLH1 ['GATTTTTTTATATAGGTTATCGACABACCG G ACTAACAGCATTTCCAAAGAT']

4575 NM_000249.3(MLHl):c.791-2A>G 4292 MLH1 ['ACTGGTTGCTTTCTTTTTATTGTTTRGATCG

TCTGGTAGAATCAACTTCCT']

4576 NM_000249.3(MLHl):c.883A>G 4292 MLH1 ['AAACACACACCCATTCCTGTACCTCVGGTA (p.Ser295Gly) ATGTAGCACCAAACTCCTCAA']

4577 NM_000249.3(MLHl):c.884+4A> 4292 MLH1 ['CACACCCATTCCTGTACCTCAGGTARTGTA G GCACCAAACTCCTCAACCAAG]

4578 NM_000251.2(MSH2):c.l277- 4436 MSH2 ['TTTGTTTGTTTTACTACTTTCTTTTVGGAAA 2A>G ACACCAGAAATTATTGTTGG']

4579 NM_000251.2(MSH2):c.1511 - 4436 MSH2 ['CTTTTTCTTTTCTTCTTGATTATCARGGCTT 2A>G GGACCCTGGCAAACAGATTA']

4580 NM_000251.2(MSH2):c.1660 A>G 4436 MSH2 ['GAAGAATGGTGTTAAATTTACCAACNGGT (p.Ser554Gly) TTGCAAGTCGTTATTATATTTT']

4581 NM_000535.5(PMS2):c.lA>G 5395 PMS2 ['CCGAGGCGGATCGGGTGTTGCATCCDTGG (p.MetlVal) AGCGAGCTGAGAGCTCGAGGTG]

4582 NM_000535.5(PMS2):c.989-2A>G 5395 PMS2 ['ATAAATATGTTTTCTTTTTTGCCTTRGAATG

CGTTGATATCAATGTTACTC]

4583 NM_000059.3(BRCA2):c.426- 675 BRCA2 ['TAAGGGATTTGCTTTGTTTTATTTTRGTCCT 2A>G GTTGTTCTACAATGTACACA']

4584 NM_024876.3(ADCK4):c.857A>G 79934 ADCK4 ['CAGCAGGAGCTGGCTTGGGAGTGTGRCTA (p.Asp286Gly) CCGTCGTGAGGCGGCTTGTGCC]

4585 NM_006005.3(WFSl):c.l385A>G 7466 WFS1 ['TACACGCGCAGGGCCCTGGCCACCGRGGT (p.Glu462Gly) CACCGCCGGCCTGCTATCGCTG]

4586 NM_000019.3 (AC AT 1 ) : c.472 A>G 38 AC ATI ['GGCAGGTGGGATGGAGAGCATGTCCRATG (p.Asnl58Asp) TTCCATATGTAATGAACAGAGG]

4587 NM_000050.4(ASSl):c.496-2A>G 445 ASS1 ['TCCACCTGTGCTGTCTCTTTCCTGCRGCAA

CACGGGATTCCCATCCCGGTC]

4588 NM_000117.2(EMD):c.450-2A>G 2010 EMD ['CCCACTTGCTCCCCTCTTTTGCCTCRGGGA

ACGCCCCATGTACGGCCGGGA']

4589 NM_000153.3(GALC):c.334A>G 2581 GALC ['GC ATAATGC ATGTGGGAGGGCTCAGB GCC (p.Thrl l2Ala) GTCTGAATAGAGGAGAGCAAAA]

4590 NM_000155.3(GALT):c.905-2A>G 2592 GALT ['CCCCACTGTCTCTCTTCTTTCTGTCRGGGG

CTCCCACAGGATCAGAGGCTG]

4591 NM_000159.3 (GCDH) :c .542 A>G 2639 GCDH ['CTCCTGGGCTGCTTCGGGCTCACAGRGCCC (p.Glul81Gly) AACAGCGGAAGTGACCCCAGC]

4592 NM_000169.2(GLA):c.509A>G -1 ['TGGGGAGTAGATCTGCTAAAATTTGRTGGT (p.Aspl70Gly) TGTTACTGTGACAGTTTGGAA']

4593 NM_000169.2(GLA):c.548-2A>G -1 - ['TATTTTACCCATTGTTTTCTCATACRGGTTA TAAGCACATGTCCTTGGCCC]

4594 NM_000169.2(GLA):c.647A>G -1 ['TCATATCTGTTTTCACAGCCCAATTRTACA (p.Tyr216Cys) GAAATCCGACAGTACTGCAAT']

4595 NM_000232.4(SGCB):c.1 A>G 6443 SGCB ['GCTCGGCGGCGGCGGGCGCGGGAAGRTGG (p.MetlVal) CGGCAGCGGCGGCGGCGGCTGC]

4596 NM_000255.3(MUT):c.l445-2A>G 4594 MUT ['TAAAATTTTTCTTTGGGAAATTACCRGGTT

CTGAAGTAATTGTTGGAGTAA']

4597 NM_000277.1 (P AH) :c .533 A>G 5053 PAH ['AGTGGGCAGCCCATCCCTCGAGTGGDATA (p.Glul78Gly) CATGGAGGAAGAAAAGAAAACA']

4598 NM_000277.1(PAH):c.974A>G 5053 PAH ['CAGATTGACTTTCCATTCCAGATTTRCTGG (p.Tyr325Cys) TTTACTGTGGAGTTTGGGCTC]

4599 NM_000328.2(RPGR):c.l55-2A>G 6103 RPGR ['TGATTATTTCTTTTTCCCTCCTACCRGGAA

ATAATAAACTTTACATGTTTG]

4600 NM_000350.2(ABCA4):c.4540- 24 ABCA4 ['ATTAACGTGGGTGTCTCATTGCCTCRGAGA 2A>G ACACAGCGCAGCACGGAAATT']

4601 NM_000350.2(ABCA4):c.67-2A>G 24 ABCA4 ['TTCTCTCTTTTTGTTTTGTTTTTCCRGATTC

GCTTTGTGGTGGAACTCGTG]

4602 NM_000487.5(ARSA):c.1108- 410 ARSA ['CCCCGTGACCCCTGACTCTGCCCCCRGAGC 2A>G CCTCGGCAGTCTCTCTTCTTC]

4603 NM_000489.4(ATRX):c.l34-2A>G 546 ATRX ['TAATGTTCTTTATTTCTTCTTTTTTRGATAA

AATCAGTGGTTCTGGAAGTA]

4604 NM_000489.4(ATRX):c.536A>G 546 ATRX ['TGCACTGCTTGTGGACAACAGGTCARTCAT (p.Asnl79Ser) TTTCAAAAAGATTCCATTTAT']

4605 NM_000512.4(GALNS):c.1171 A> 2588 GALNS ['CTTCTATTACCGTGGCGACACGCTGRTGGC G (p.Met391Val) GGCCACCCTCGGGCAGCACAA']

4606 NM_000521.3(HEXB):c.l243- 3074 HEXB ['ATGTATTGCAATTTGTAACGTTAATRGCTT 2A>G GCGCCGGGCACAATAGTTGAA']

4607 NM_000531.5(OTC):c.238A>G 5009 OTC ['ATAGTATTTGCCTTTATTGCAAGGGRAGTC (p.Lys80Glu) CTTAGGCATGATTTTTGAGAA']

4608 NM_000551.3(VHL):c.233A>G 7428 VHL ['GAGCCCTCCCAGGTCATCTTCTGCARTCGC (p.Asn78Ser) AGTCCGCGCGTCGTGCTGCCC]

4609 NM_001848.2(COL6Al):c.805- 1291 COL6A1 ['CCAACCTTGACCTGTTTTGTGTTCCRGGGA 2A>G GAACGAGGCAAGCCGGGGCTC]

4610 NM_001918.3(DBT):c.773-2A>G 1629 DBT ['AATGAATAACAATTTAATGCTTTTCRGGCT

TTCAAAAAGCAATGGTCAAGA']

4611 NM_003482.3(KMT2D):c.5645- 8085 KMT2D ['TCAACAGTGTCCTTCATTCCCCCACRGAAC 2A>G TGCCCAAGATGGAATCCAAGG]

4612 NM_003494.3(DYSF):c.l398- 8291 DYSF ['CAGGCCCTCTCTGCTCCCTTGCTCTRGGGA 2A>G CCGCCTGACTCACAATGACAT']

4613 NM_004006.2(DMD):c.1332-9 A>G 1756 DMD ['AAGAGGTCATAATAGGCTTCTTTCAVATTT

TCAGTTTACATAGAGTTTTAA]

4614 NM_004006.2(DMD):c.3432+3A> 1756 DMD ['AGTGGGATCACATGTGCCAACAGGTRTAG G ACAATCTCTTTCACTGTGGCTT']

4615 NM_004006.2(DMD):c.6763-2A>G 1756 DMD ['AAACGTTGTTGCATTTGTCTGTTTCRGTTA CTGGTGGAAGAGTTGCCCCTG]

4616 NM_004006.2(DMD):c.9224+6193 1756 DMD ['AGCTGTGAATGCTTCATTCAGGCCCRAGTA 4A>G AATATAGGAAGAGGTGTAGTG]

4617 NM_004006.2(DMD):c.9225- 1756 DMD ['GCTGTGAATGCTTCATTCAGGCCCARGTAA 647A>G ATATAGGAAGAGGTGTAGTGG]

4618 NM_004006.2(DMD):c.9650-2A>G 1756 DMD ['TGTTGCAATTTTCTTCTTCCTTTGTRGACCT

TTTCAAGCAAGTGGCAAGTT']

4619 NM_015560.2(OPAl):c.983A>G 4976 OPA1 ['GAGATGATGACACGTTCTCCAGTTAVGGT (p.Lys328Arg) AAGAACATAGGCCGTCTCAGTG]

4620 NM_144997.5(FLCN):c. l433- 20116 FLCN ['TTGCTCTGCCCCTGCCCTTCTCCCCRGTGG 2A>G 3 GCCCCACCATCCTGAATAAGA]

4621 M_144997.5(FLCN):c.250-2A>G 20116 FLCN ['AGATTTACTTTTCCTTTTCATGGACRGGGC

3 TGCCGGTCACTTGCTGCAGGG]

4622 NM_000146.3(FTL):c.lA>G 2512 FTL ['GTTAGCTCCTTCTTGCCAACCAACCRTGAG (p.MetlVal) CTCCCAGATTCGTCAGAATTA']

4623 NM_024531.4(SLC52A2):c.914A> 79581 SLC52A2 ['GTGCAGAGCTTTTCCTGCTTACCCTRCGGG G (p.Tyr305Cys) CGTCTGGCCTACCACCTGGCT']

4624 NM_001743.5(CALM2):c.293A>G 805 CALM2 ['TACTAAATTTTTTGCTAGGATGGCADTGGC (p.Asn98Ser) TATATTAGTGCTGCAGAACTT']

4625 M_014754.2(PTDSSl):c. l058A> 9791 PTDSS1 ['ACACAGTGCAAGCGCGTAGGAACACRATG G (p.Gln353Arg) CTGGGTGTTTGGGTGAGTAATC]

4626 NM_052844.3(WDR34):c.l307A> 89891 WDR34 ['GGACCAGCGCACAGCAAACAGATACYTGA G (p.Lys436Arg) GGGAGAGCTGCAGCGAAGTCAA']

4627 NM_001130010.2(C15orf41):c.281 84529 C15orf41 ['TACTTCTGTTTTATAAAGGTGGACTVTGCG A>G (p.Tyr94Cys) CCCTCATTAATGGCTCGGCTT']

4628 NM_001290048.1(ATL3):c.521A> 25923 ATL3 ['AATTTCATCCATTGCCAGACGACCGYATTC G (p.Tyrl74Cys) TGTGAAGAGCTTTAAAAAAGA']

4629 NM_000531.5(OTC):c.l034A>G 5009 OTC ['GTCATGGTGTCCCTGCTGACAGATTRCTCA (p.Tyr345Cys) CCTCAGCTCCAGAAGCCTAAA']

4630 NM_000531.5(OTC):c.l22A>G 5009 OTC ['AATAAAGTGCAGCTGAAGGGCCGTGRCCT (p.Asp41Gly) TCTCACTCTAAAAAACTTTACC]

4631 NM_000531.5(OTC):c.l55A>G 5009 OTC ['ACTCTAAAAAACTTTACCGGAGAAGRAAT (p.Glu52Gly) TAAATATATGCTATGGCTATCA']

4632 NM_000531.5 (OTC) :c .1 A>G 5009 OTC ['TCGTCCTTTACACAATTAAAAGAAGDTGCT (p.MetlVal) GTTTAATCTGAGGATCCTGTT']

4633 NM_000531.5(OTC):c.268A>G 5009 OTC ['CTTAGGCATGATTTTTGAGAAAAGARGTA (p.Ser90Gly) CTCGAACAAGATTGTCTACAGA']

4634 NM_000531.5(OTC):c.277A>G 5009 OTC ['GATTTTTGAGAAAAGAAGTACTCGARCAA (p.Thr93Ala) GATTGTCTACAGAAACAGGTAA']

4635 NM_000531.5(OTC):c.350A>G 5009 OTC ['TGTTTTCTTACCACACAAGATATTCDTTTG (p.Hisll7Arg) GGTGTGAATGAAAGTCTCACG]

4636 NM_000531.5(OTC):c.377A>G 5009 OTC ['TTGGGTGTGAATGAAAGTCTCACGGRCAC (p.Aspl26Gly) GGCCCGGTTTGTAAATATTTTC]

4637 NM_000531.5(OTC):c.387-2A>G 5009 OTC ['GATTATCTTTTTCTTGGTTTGCCACNGTGT ATTGTCTAGCATGGCAGATGC]

4638 NM_000531.5(OTC):c.481A>G 5009 OTC ['TAAAGAAGCATCCATCCCAATTATCRATG (p.Asnl61Asp) GGCTGTCAGATTTGTACCATCC]

4639 NM_000531.5(OTC):c.482A>G 5009 OTC ['AAAGAAGCATCCATCCCAATTATCARTGG (p.Asnl61Ser) GCTGTCAGATTTGTACCATCCT']

4640 NM_000531.5(OTC):c.503A>G 5009 OTC ['ATCAATGGGCTGTCAGATTTGTACCVTCCT (p.Hisl68Arg) ATCCAGATCCTGGCTGATTAC]

4641 NM_000531.5(OTC):c.524A>G 5009 OTC ['TACCATCCTATCCAGATCCTGGCTGDTTAC (p.Aspl75Gly) CTCACGCTCCAGGTTGGTTTA']

4642 NM_000531.5(OTC):c.527A>G 5009 OTC ['CATCCTATCCAGATCCTGGCTGATTRCCTC (p.Tyrl76Cys) ACGCTCCAGGTTGGTTTATTT']

4643 NM_000531.5(OTC):c.541-2A>G 5009 OTC ['TCATCTCCTTCATCCCGTGCCTTTTRGGAA

CACTATAGCTCTCTGAAAGGT']

4644 NM_000531.5(OTC):c.542A>G 5009 OTC ['TCTCCTTCATCCCGTGCCTTTTAGGRACAC (p.Glul81Gly) TATAGCTCTCTGAAAGGTCTT']

4645 NM_000531.5(OTC):c.548A>G 5009 OTC ['TCATCCCGTGCCTTTTAGGAACACTRTAGC (p.Tyrl83Cys) TCTCTGAAAGGTCTTACCCTC]

4646 NM_000531.5(OTC):c.595A>G 5009 OTC ['CCTCAGCTGGATCGGGGATGGGAACRATA (p.Asnl99Asp) TCCTGCACTCCATCATGATGAG]

4647 NM_000531.5(OTC):c.596A>G 5009 OTC ['CTCAGCTGGATCGGGGATGGGAACARTAT (p.Asnl99Ser) CCTGCACTCCATCATGATGAGC]

4648 NM_000531.5(OTC):c.613A>G 5009 OTC ['TGGGAACAATATCCTGCACTCCATCRTGAT (p.Met205Val) GAGC GC AGC G A A ATTC GG A AT']

4649 NM_000531.5(OTC):c.716A>G 5009 OTC ['AAGTTGGC AGAGC AGT ATGCC AAAGD GGT (p.Glu239Gly) ATGCTCTTTACATGTAAAGCTA]

4650 NM_000531.5 (OTC) :c .717+3 A>G 5009 OTC ['TGGCAGAGCAGTATGCCAAAGAGGTRTGC

TCTTTACATGTAAAGCTATTAT']

4651 NM_000531.5(OTC):c.718-2A>G 5009 OTC ['TTTAACCAGCGTGTTTATGTATGCTRGAAT

GGTACCAAGCTGTTGCTGACA']

4652 NM_000531.5(OTC):c.788A>G 5009 OTC ['CATGGAGGCAATGTATTAATTACAGRCAC (p.Asp263Gly) TTGGATAAGCATGGGACAAGAA']

4653 NM_000531.5(OTC):c.790A>G 5009 OTC ['TGGAGGCAATGTATTAATTACAGACRCTTG (p.Thr264Ala) GATAAGCATGGGACAAGAAGA]

4654 NM_000531.5(OTC):c.905A>G 5009 OTC ['GCTGCCTCTGACTGGACATTTTTACDCTGC (p.His302Arg) TTGCCCAGAAAGCCAGAAGAA']

4655 NM_000531.5(OTC):c.929A>G 5009 OTC ['CACTGCTTGCCCAGAAAGCCAGAAGRAGT (p.Glu310Gly) GGATGATGAAGTCTTTTATTCT']

4656 NM_000531.5(OTC):c.988A>G 5009 OTC ['ACTAGTGTTCCCAGAGGCAGAAAACRGAA (p.Arg330Gly) AGTGGACAATCATGGTAAGCAA']

4657 NM_000322.4(PRPH2):c.422A>G 5961 PRPH2 ['GGGCTCAAGAACGGCATGAAGTACTRCCG (p.Tyrl41Cys) GGACACAGACACCCCTGGCAGG]

NM_003590.4(CUL3):c.l207- 8452 CUL3 []

26A>G

NM_003590.4(CUL3):c.l376A>G 8452 CUL3 [] (p.Lys459Arg)

NM_003590.4(CUL3):c.l377+3A> 8452 CUL3 []

G

4658 NM_017415.2(KLHL3):c.232A>G 26249 KLHL3 ['AGCCTGCAGCCCCTACTTCTGTGCGDTGTT (p.Met78Val) CACAGGTATGGTGAGTGGCCA]

NM_017415.2(KLHL3):c.926A>G 26249 KLHL3 []

(p.Gln309Arg)

4659 NM_005763.3(AASS):c.874A>G 10157 AASS ['CTCACATCAGTATTAAAACGACTTAYGTA (p.Ile292Val) GCGCTCCGGATGTTTGTCATAC]

4660 NM_000203.4(IDUA):c. l874A>G 3425 IDUA ['TCCTACCGAGTTCGAGCCCTGGACTRCTGG (p.Tyr625Cys) GCCCGACCAGGCCCCTTCTCG]

4661 NM_000546.5(TP53):c.736A>G 7157 TP53 ['GTGTAACAGTTCCTGCATGGGCGGCVTGA (p.Met246Val) ACCGGAGGCCCATCCTCACCAT']

4662 M_194442.2(LBR):c.l639A>G 3930 LBR ['GCCATGATGAGATCACCCAAGTAATYGGG (p.Asn547Asp) GTGGCGAACAAAGCCCCACCAT']

4663 NM_000090.3(COL3Al):c.2284- 1281 COL3A1 ['ATTAAAAAATATTTTTATTTCCTCTRGGGT 2A>G (p.Gly762_Lys779del) CCTACTGGTCCTATTGGTCCT']

4664 NM_000090.3(COL3Al):c.997- 1281 COL3A1 ['TCTTGAAATTGTATTTAATTTTTTCRGGGC 2A>G (p.Gly333_Lys350del+) CCTCCTGGTCCTCCTGGAACT']

4665 NM_000090.3(COL3Al):c.3418- 1281 COL3A1 ['CATTGTGATGTCATGATACTTTCTTDGGGA 2A>G CCTGTTGGACCCAGTGGACCT']

(p. Argl 139_Glyl 140insVSSTERY

YRSTCFRCLHFRKIFWHCDVMI LSW)

4666 NM_000090.3(COL3Al):c.997- 1281 COL3A1 ['AAAAGAGCTCTTGAAATTGTATTTARTTTT 10A>G (p.Pro332_Gly333insFFQ) TTCAGGGCCCTCCTGGTCCTC]

4667 NM_000090.3(COL3Al):c. l870- 1281 COL3A1 ['ACAGAGTGTATCATTATACTTTTCTDGGGG 2A>G (p.Gly624_Gln641del) CCTGGTGGTGACAAAGGAGAC]

4668 NM_000090.3(COL3Al):c.3202- 1281 COL3A1 ['CTTCTCAATTGAATGTTTTCATCTTRGGGC 2A>G (p.Glyl068_Prol085del) CCTGCTGGCCCTGCTGGTGCT']

4669 NM_000090.3(COL3Al):c. l762- 1281 COL3A1 ['AGTAAATACCGACCACTTCTTCTTTRGGGT 2A>G (p.Gly588_Gln605del) GCTCCTGGTAAGAATGGAGAA']

4670 NM_003611.2(OFDl):c.935+706A 8481 OFD1 ['CTTTTTGGCAATAATGAAAAGGTAARTTGA >G TCAAGAGAGAGGAAATAGGCA']

4671 M_014740.3 (EIF4 A3 ) :c .809 A>G 9775 EIF4A3 ['AGTGATGGTCAGTGTGTCGTAGAGGYCAC (p.Asp270Gly) ACAGAGTGTCAAATTTCCACTC]

4672 NM_001040436.2(YARS2):c.l303 51067 YARS2 ['TTTGTTACTTGTTGGTGATTTATGCYGACT A>G (p.Ser435Gly) CCGCCTTCTGTTATCATTCGA']

4673 NM_000277.1 (P AH) :c .1157 A>G 5053 PAH ['ACTGTCACGGAGTTCCAGCCCCTCTRTTAC (p.Tyr386Cys) GTGGCAGAGAGTTTTAATGAT']

4674 NM_000277.1(PAH):c.812A>G 5053 PAH ['TTCCACTGCACACAGTACATCAGACDTGG (p.His271Arg) ATCCAAGCCCATGTATACCCCC]

4675 NM_004820.3(CYP7Bl):c.889A>G 9420 CYP7B1 ['ATTGCCCAGAACATAGTTGGAATAGYGTT (p.Thr297Ala) TGCCACAGAGGCCCAGAGAAAG] 4676 NM_024301.4(FKRP):c.lA>G 79147 FKRP ['CCAGCTAGCCCCAGACTTCGGCCCCRTGCG (p.MetlVal) GCTCACCCGCTGCCAGGCTGC]

4677 NM_001955.4(EDNl):c.271A>G 1906 EDN1 ['GTATGGACTTGGAAGCCCTAGGTCCRAGA (p.Lys91Glu) GAGCCTTGGAGAATTTACTTCC]

4678 NM_198947.3(FAMl l lB):c.l879A 37439 FAM111B ['TAATGTATACTGTATGTTTACCCAARGAAG >G (p.Arg627Gly) 3 TTTCCTATCAGAGGTTTGGAA']

4679 NM_001282227.1(CECRl):c.l232 51816 CECR1 ['GCCCATGAAGACCTCATAGAAATCAYAGG A>G (p.Tyr411Cys) ACAAGCCTTTGGCACCAAACAT']

4680 NM_033419.4(PGAP3):c.914A>G 93210 PGAP3 ['TGATTCCTTCAGCAGGTACAGGCTGYCATC (p.Asp305Gly) TTCCAGAAAGCTGTGGGCCAA]

4681 NM_007294.3(BRCAl):c.l35- 672 BRCA1 ['TGTTCTTTCTTTCTTTATAATTTATRGATTT 2A>G TGCATGCTGAAACTTCTCAA']

4682 NM_007294.3(BRCAl):c.4676- 672 BRCA1 ['AAATTAAACTTCTCCCATTCCTTTCRGAGG

2A>G GAACCCCTTACCTGGAATCTG]

4683 M_015474.3(SAMHDl):c.l l53A 25939 SAMHD1 ['GGAAATGACAATCAAGTTTCTTACAYTGT >G (p.Met385Val) ATCAATAATGTTGCCAACTTTG]

4684 NM_015474.3(SAMHDl):c.l411- 25939 SAMHD1 ['TTTTGGAAGAGATTCATAGTCCTCCYGGAA 2A>G AACACAAGACTCCCCATGTTA']

4685 NM_000097.5(CPOX):c.980A>G 1371 CPOX ['ACCAATGCCCCGCCGTTCTCCACGAYGGG (p.His327Arg) CTATAAAGAAGTAATCATCACA]

4686 NM_012338.3(TSPAN12):c.413A> 23554 T SPAN 12 ['AAGCCACCGATATCTAGGTAATCCAYAAT G (p.Tyrl38Cys) TTGTCATCCTGGCTTTCAAAGT']

4687 NM_000406.2(GNRHR):c.94A>G 2798 GNRHR ['GTCACTCGGATCTTTCCAGACAAGGYCAG (p.Thr32Ala) AGTGGGGAGGTTGCCCTGCATC]

4688 NM_199189.2(MATR3):c. l864A> 9782 MATR3 ['TGGTTCCCAGAAGACTGAGAGTTCARCCG G (p.Thr622Ala) AAGGTAAAGAACAAGAAGAGAA']

4689 NM_003181.3(T):c.512A>G 6862 T ['CTGTGGACCCCCAACTCTCACTATGYGGAT (p.Hisl71Arg) TCGAGGCTCATACTTATGCAA']

4690 NM_000321.2(RBl):c.l927A>G 5925 RBI ['AGCCTTCCAGACCCAGAAGCCATTGRAAT (p.Lys643Glu) CTACCTCTCTTTCACTGTTTTA]

4691 NM_002234.3(KCNA5):c.l43A>G 3741 KCNA5 ['GCTGGGCTCAGCGATGGGCCCAAGGRGCC (p.Glu48Gly) GGCGCCAAAGGGGCGCGGCGCG]

4692 NM_178014.3(TUBB):c.895A>G 20306 TUBB ['CCAGCAGGTCTTCGATGCCAAGAACRTGA (p.Met299Val) 8 TGGCTGCCTGTGACCCCCGCCA']

4693 NM_000136.2(FANCC):c.-78- 2176 FANCC ['TGCTTCTATTTGTTCCCTTTCTTACRGATTT 2A>G AATGTGTGCCGACCATTTCC]

4694 NM_000546.5(TP53):c.488A>G 7157 TP53 ['CTCCGTCATGTGCTGTGACTGCTTGYAGAT (p.Tyrl63Cys) GGCCATGGCGCGGACGCGGGT']

4695 NM_000546.5(TP53):c.659A>G 7157 TP53 ['TTTCGACATAGTGTGGTGGTGCCCTVTGAG (p.Tyr220Cys) CCGCCTGAGGTCTGGTTTGCA]

4696 NM_000546.5(TP53):c.701A>G 7157 TP53 ['GGCTCTGACTGTACCACCATCCACTRCAAC (p.Tyr234Cys) TACATGTGTAACAGTTCCTGC]

4697 NM_002878.3(RAD51D):c.lA>G -1 ['CACAGTCCGACCCTGAGCACGCCCAYGTT (p.MetlVal) CCCCGCAGGCCGGAACAGCCCC] 4698 NM_058216.2(RAD51C):c.706- 5889 RAD51C ['ATCTAATATTATCTCTTCTGTATTTRGGTTC 2A>G GACTAGTGATAGTGGATGGT']

4699 NM_015713.4(RRM2B):c.556A>G 50484 RRM2B ['TCTACAGCAGCAAAGGCCACCACTCYTTC (p.Argl86Gly) CCCTGGGAGACATAAAATCGTT']

4700 NM_015713.4(RRM2B):c.581A>G 50484 RRM2B ['AAAAGATCCTGAGAAGAAAACTCCTYCTA (p.Glul94Gly) CAGCAGCAAAGGCCACCACTCT']

4701 NM_000219.5(KCNEl):c.242A>G 3753 KCNE1 ['CACTCGAACGACCCATTCAACGTCTDCATC (p.Tyr81Cys) GAGTCCGATGCCTGGCAAGAG]

4702 NM_000271.4(NPCl):c.l832A>G 4864 NPC1 ['TTCACTGCTGAACGAAGTATTGAAGRTGA (p.Asp611Gly) ACTAAATCGTGAAAGTGACAGT']

4703 NM_000257.3(MYH7):c. l952A>G 4625 MYH7 ['CTGGGGCTGTGTCCCACTCACCCTGYGCAG (p.His651Arg) AGCTGACACAGTCTGAAAGGA']

4704 NM_000540.2(RYRl):c.7043A>G 6261 RYR1 ['GGGTGGCCAGGCGAGAGCGTGGAGGRGA (p.Glu2348Gly) ACGCCAATGTGGTGGTGCGGCTG]

4705 NM_058216.2(RAD51C):c.l027- 5889 RAD51C ['TTTGTATATATATTTTTTATCTTTCRGCCTC 2A>G AGGGATTTAGAGATACTGTT']

4706 NM_130838.1(UBE3A):c. l694- 7337 UBE3A ['TGTATTTTTAAAAATCATTTCTTATRGGTA 2A>G TGTTCACATACGATGAATCTA]

4707 NM_022168.3(IFIHl):c.l009A>G 64135 IFIH1 ['TCCTTGGCAATGTAAACAGCCACTCYGGTT (p.Arg337Gly) TTTCCACTCCCTGTAGGGAGG]

4708 NM_022068.3(PIEZO2):c.2134A> 63895 PIEZ02 ['GCCACACAGAACAGGAACAGCACCAYGTA G (p.Met712Val) GATGATTTTGTACATTACGATT']

4709 NM_001164342.2(ZBTB20):c.l787 26137 ZBTB20 ['ACCGCCAAACAGAACTACGTCAAGCRCAT A>G (p.His596Arg) GTTCGTACACACAGGTGAGTGT']

4710 NM_001128159.2(VPS53):c.2084A 55275 VPS53 ['TGCCTGATACTACGTCCATCTCACCYGTTC >G (p.Gln695Arg) TGCTCCCACCATGCTAATTGG]

4711 NM_003108.3(SOXl l):c.347A>G 6664 SOX11 ['AAGCACATGGCCGACTACCCCGACTRCAA (p.Tyrl l6Cys) GTACCGGCCCCGGAAAAAGCCC]

4712 NM_020435.3(GJC2):c.-170A>G 57165 GJC2 ['TTCAGACCCTGAGGCCGAGGGGGGARCAA

TGGGGCCCTTGAGGGCCCCTCC]

4713 NM_004817.3(TJP2):c.l992-2A>G 9414 TJP2 ['GATTTACTTCCCGTGGTTTCTTCTCRGAGC

TGAACAAATGGCCAGTGTTCA']

4714 NM_017565.3(FAM20A):c.720- -1 ['GGTGTCTCCTCATCTCGCTGCTGTCYGGAA 2A>G GGAAGGAAGGAATCACGCCCT']

4715 NM_002764.3(PRPSl):c.343A>G 5631 PRPS1 ['AATCTCAGCCAAGCTTGTTGCAAATRTGCT (p.Metl l5Val) ATCTGTAGCAGGTGCAGATCA']

4716 NM_000216.2(ANOSl):c.lA>G 3730 ANOS1 ['TCGCCCTCGCCCTCGACCCGCAGCCRTGGT (p.MetlVal) GCCCGGGGTGCCCGGCGCGGT']

4717 NM_031229.2(RBCKl):c.1160 A> 10616 RBCK1 ['TGGTGCTTCTTTGAGGATGATGTCARTGAG G (p.Asn387Ser) TTCACCTGCCCTGTGTGTTTC]

4718 NM_015599.2(PGM3):c.737A>G 5238 PGM3 ['CACAAAGTCAGCTCCACATAAATGAYTGA (p.Asn246Ser) GTTTGCCCTTGGACCCATCATT']

4719 NM_015599.2(PGM3):c.l352A>G 5238 PGM3 ['TTTCTCTCACACCTGAACTTTAAGTYGTCT (p.Gln451Arg) GTTTGGAAGATCTGTATAGAG] 4720 NM_000535.5(PMS2):c.904-2A>G 5395 PMS2 ['CTTTTCTACTCCTTGTATTTTGTGCRGGTCT

GCAGACTCGTGAATGAGGTC]

4721 NM_000546.5(TP53):c.358A>G 7157 TP53 ['GGGCTTCTTGCATTCTGGGACAGCCDAGTC (p.Lysl20Glu) TGTGACTTGCACGGTCAGTTG]

4722 NM_000546.5(TP53):c.842A>G 7157 TP53 ['CGTGTTTGTGCCTGTCCTGGGAGAGDCCGG (p.Asp281Gly) CGCACAGAGGAAGAGAATCTC]

4723 NM_001128425.1(MUTYH):c. ll87 4595 MUTYH ['CCCCTGCCTGGCTGCCCTCCCTCTCRGGTC -2A>G TGCTGGCAGGACTGTGGGAGT']

4724 NM_000546.5(TP53):c. ll01-2A>G 7157 TP53 ['TCTCCTCCCTGCTTCTGTCTCCTACRGCCAC

CTGAAGTCCAAAAAGGGTCA']

4725 NM_000314.6(PTEN):c.493-2A>G 5728 PTEN ['GGCTTCTCTTTTTTTTCTGTCCACCRGGGA

GTAACTATTCCCAGTCAGAGG]

4726 NM_000051.3(ATM):c.3994-2A>G 472 ATM ['ATATATTTTAATTTTGTGCCCTTGCRGATT

GATCACTTATTCATTAGTAAT']

4727 NM_000314.6(PTEN):c.403A>G 5728 PTEN ['TGGAAAGGGACGAACTGGTGTAATGRTAT (p.Ilel35Val) GTGCATATTTATTACATCGGGG]

4728 NM_000249.3(MLHl):c.l l7-2A>G 4292 MLH1 ['TAAATTATTTTCTGTTTGATTTGCCDGTTTA

GATGCAAAATCCACAAGTAT']

4729 NM_025150.4(TARS2):c.695+3A> 80222 TARS2 ['GGTCCAACAGCAACAGTATATGGGTRAGA G GTTGTCAAGATTAAGGCAAACA']

4730 NM_206933.2(USH2A):c. l0544A> 7399 USH2A ['TGGACCAAAATAGACAATCTTGAAGVTAC G (p.Asp3515Gly) AATTGTCTTAAACTGGAGAAAA']

4731 NM_000834.3(GRIN2B):c. l238A> 2904 GRIN2B ['CATCTGAGCATTGTGACCCTGGAGGRGGC G (p.Glu413Gly) ACCATTTGTCATTGTGGAAAGT']

4732 NM_004830.3(MED23):c.3638A> 9439 MED23 ['TGTAGCTATACGTTAGCTCTTGCACRTGCT G (p.Hisl213Arg) GTGTGGCACCATTCTAGCATC]

4733 NM_003159.2(CDKL5):c.l25A>G 6792 CDKL5 ['GAAACACATGAAATTGTGGCGATCARGAA (p.Lys42Arg) ATTCAAGGACAGTGAAGGTAGA']

4734 NM_003159.2(CDKL5):c.380A>G 6792 CDKL5 ['CTAATCAAGGCTATTCACTGGTGCCRTAAG (p.Hisl27Arg) AATGATATTGTCCATCGAGGT']

4735 NM_003159.2(CDKL5):c.578A>G 6792 CDKL5 ['AGCGCTCCCTATGGAAAGTCCGTGGRCAT (p.Aspl93Gly) GTGGTCGGTGGGCTGTATTCTT']

4736 NM_198282.3(TMEM173):c.461A 34006 TMEM173 ['TGACCATGCCAGCCCATGGGCCACGYTGA >G (p.Asnl54Ser) 1 AATTCCCTTTTTCACACACTGC]

4737 NM_032018.6(SPRTN):c.350A>G 83932 SPRTN ['CTCCTGCATGAAATGATACATGCCTRTTTA (p.Tyrl l7Cys) TTTGTCACTAATAACGACAAA]

4738 NM_001759.3(CCND2):c.838A>G 894 CCND2 ['GGAGGATGAACTGGACCAAGCCAGCRCCC (p.Thr280Ala) CTACAGACGTGCGGGATATCGA']

4739 NM_007315.3(STATl):c.854A>G 6772 STAT1 ['AGGGTCATGTTCGTAGGTGTATTTCYGTTC (p.Gln285Arg) CAATTCCTCCAACTTTTTAAG]

4740 NM_139276.2(STAT3):c.l l75A>G 6774 STAT3 ['GTTGGATTCTTCCATGTTCATCACTYTTGT (p.Lys392Arg) GTTTGTGCCCAGAATGTTAAA']

4741 NM_001037811.2(HSD17B10):c.25 3028 HSD17B10 ['GATGCCTGCACAGTTGACAGCTACAYCCA 7A>G (p.Asp86Gly) CACGGCCAAACTTTCCTTTTGC] 4742 NM_005726.5(TSFM):c.57+4A>G 10102 TSFM ['CGCGCGGACCGGGAGCTACCCGGTGRGAA

GTCCTGGTGCTGGTACCGACCT']

4743 NM_000166.5(GJBl):c.580A>G 2705 GJB1 ['CGAGAAAACCGTCTTCACCGTCTTCRTGCT (p.Metl94Val) AGCTGCCTCTGGCATCTGCAT']

4744 NM_001077494.3(NFKB2):c.2594 4791 NFKB2 ['TTACCCCCAGCAGAGGTGAAGGAAGRCAG A>G (p.Asp865Gly) TGCGTACGGGAGCCAGTCAGTG]

4745 NC_012920.1 :m.5559A>G 4578 MT-TW ['TGTTACAGAAATTAAGTATTGCAACYTACT

GAGGGCTTTGAAGGCTCTTGG]

4746 NC_012920.1 :m.l3514A>G 4540 MT-ND5 ['TTCCTCACAGGTTTCTACTCCAAAGRCCAC

ATCATCGAAACCGCAAACATA']

4747 NM_007315.3(STATl):c.2018A>G 6772 STAT1 ['GTAATACTTTCCAAAGGCATGGTCTYTGTC (p.Lys673Arg) AATATTTGGATACAGATACTT']

4748 NM_007315.3(STATl):c.l909A>G 6772 STAT1 ['GGGAAAGTAACAGCAGAAAGTTCTTYCTT (p.Lys637Glu) CGTGTAGGGTTCAACCGCATGG]

4749 NM_000060.3(BTD):c.683A>G 686 BTD ['GCATTCGATGTTCCTCTTAAAGTGGRTCTC (p.Asp228Gly) ATCACCTTTGATACCCCCTTT']

4750 NM_004992.3(MECP2):c.27-2A>G 4204 MECP2 ['TACTTACATACTTGTTTAACACTTCRGGGA

AGAAAAGTCAGAAGACCAGGA']

4751 NM_004992.3(MECP2):c378- 4204 MECP2 ['CTTGTGTCTTTCTGTTTGTCCCCACNGTCCC 2A>G CAGGGAAAAGCCTTTCGCTC]

4752 NM_003159.2(CDKL5):c.l00- 6792 CDKL5 ['TTTCCTTCTGCTTCTTTTCCCTTGCRGGAAA 2A>G CACATGAAATTGTGGCGATC]

4753 NM_003159.2(CDKL5):c.464- 6792 CDKL5 ['ACAACTTTGGACTTTGCTATCTTTCRGGTT 2A>G TTGCTCGTAATCTGTCAGAAG]

4754 NM_003159.2(CDKL5):c.978- 6792 CDKL5 ['GATATACTTCTTTTGTTTTTAACATRGAAA 2A>G CCAAGCCGGCAAAAGTACTGC]

4755 NM_032492.3(JAGNl):c.485A>G 84522 JAGN1 ['TTGGCAGTGCAAGTGCATGCCTGGCRGTTG (p.Glnl62Arg) TACTACAGCAAGAAGCTCCTA]

4756 NM_178517.3(PIGW):c.499A>G 28409 PIGW ['AACTGAGCTCTATGGGACAGGAGCARTGG (p.Metl67Val) 8 ATTTTGGAGTAGGTGGCTTTGT']

4757 NM_004387.3(NKX2-5):c.461A>G 1482 NKX2-5 ['TCGCAGGCGCAGGTCTATGAGCTGGRGCG (p.Glul54Gly) GCGCTTCAAGCAGCAGCGGTAC]

4758 NM_005859.4(PURA):c.289A>G 5813 PURA ['CGCCGAGGTGGGCGCGGGCGGCAACRAGA (p.Lys97Glu) GCCGCCTTACTCTCTCCATGTC]

4759 M_004046.5(ATP5Al):c.962A>G 498 ATP5A1 ['GCGGAGCAACAGAGACATCTGACGGHAAG (p.Tyr321Cys) CAACAGCCTATGGTACAGAATA']

4760 NM_000038.5(APC):c.l744-2A>G 324 APC ['GATGACCCATATTCTGTTTCTTACTRGGAA

TCAACCCTCAAAAGCGTATTG]

4761 NM_000751.2(CHRND):c. l319A> 1144 CHRND ['TTCAATGAGCTGAAGCCAGCTGTGGWTGG G (p.Asp440Gly) GGCAAACTTCATTGTTAACCAC]

4762 NM_130466.3(UBE3B):c.lA>G 89910 UBE3B ['GCAGGGTTTGTGCAAGTTTGCAAACRTGTT (p.MetlVal) CACCCTGTCTCAGACCTCGAG]

4763 NM_003159.2(CDKL5):c.211A>G 6792 CDKL5 ['AATGCTTCGGACTCTCAAGCAGGAARACA (p.Asn71Asp) TTGTGGAGTTGAAGGAAGCATT'] 4764 NM_003159.2(CDKL5):c.404- 6792 CDKL5 ['AATTTTTTTTTTATCTTGACACTCCRGATAT 2A>G AAAACCAGAAAATCTCTTAA']

4765 NM_003159.2(CDKL5):c.449A>G 6792 CDKL5 ['TTAATCAGCCACAATGATGTCCTAARACTG (p.Lysl50Arg) TGTGACTTTGGTAAGTTAAAA']

4766 NM_001813.2(CENPE):c.4063A>G 1062 CENPE ['ACTTCAAGGGCTTCTTTTATCGTTTYAAGG (p.Lysl355Glu) TTGTCTCTTTCCTTGGTTAGA']

4767 NM_023073.3(C5orf42):c.3290- 65250 C5orf42 ['ATTTTACCAAATTTTTGTATTTGATRGATC 2A>G CCATTGAAGAGGAAGATGCAA']

4768 NM_002977.3(SCN9A):c.2215A>G -1 ['GTGTTTAAAACTATGCAAATGGTAAYTGC (p.Ile739Val) AAGATCTACAAAAGGATCCATT']

4769 NM_002354.2(EPCAM):c.556- 4072 EPCAM ['TATTAGTATTAATTTGTATTATTCANTTTTT 14A>G TTCCCCAGTATGAGAATAAT']

4770 NM_002354.2(EPCAM):c.492- 4072 EPCAM ['TTAATACAGATTTTAAATTCTTTACRGTGC 2A>G ACTTCAGAAGGAGATCACAAC]

4771 NM_000053.3(ATP7B):c.l22A>G 540 ATP7B ['ATCCAGACCACCTTCATAGCCAACAYTGTC (p.Asn41Ser) AAAAGCAAAACTCTTCTTCAT']

4772 NM_022455.4(NSDl):c.4498- 64324 NSD1 ['ATGTGGGACATTATTTTTTCTTTGCRAGGG 3A>G AGAACTAATGCCTCACAGGAC]

4773 NM_022455.4(NSDl):c.5893- 64324 NSD1 ['TAAGTCAGGAGGTATTTCTTGTTCTRGGGT 2A>G GAATTTGTGAATGAGTATGTG]

4774 NM_022455.4(NSDl):c.6059A>G 64324 NSD1 ['AAAGGAAACTATGCTCGGTTCATGARTCA (p.Asn2020Ser) TTGCTGCCAGCCCAACTGTGAA']

4775 NM_022455.4(NSDl):c.6356A>G 64324 NSD1 ['GGTGAAATCACAAAGGAGCGAGAAGRTGA (p.Asp2119Gly) GTGTTTTAGTTGTGGGGATGCT']

4776 NM_133433.3(NIPBL):c.737A>G 25836 NIPBL ['AATCCTAGACATGGTTCAAGTGAGGRCTA (p.Asp246Gly) CCTACACATGGTGCACAGGCTA']

4777 NM_133433.3(NIPBL):c.5428- 25836 NIPBL ['TGTTTTTTTCTCTTCATTTTTCTTTRGCTTG 2A>G ATATGCAACGAGGTGTTCAT']

4778 NM_005249.4(FOXGl):c.757A>G 2290 FOXG1 ['CCACTACGACGACCCGGGCAAGGGCRACT (p.Asn253Asp) ACTGGATGCTGGACCCGTCGAG]

4779 NM_004380.2(CREBBP):c.4508A> 1387 CREBBP ['AAGCCAAAACGACTGCAGGAGTGGTRCAA G (p.Tyrl503Cys) AAAGATGCTGGACAAGGCGTTT']

4780 NM_004380.2(CREBBP):c3983- 1387 CREBBP ['CTCACCTGCTCCTTCTGGACTTCCTRGGGC 2A>G TGCAGACCACAAGACTGGGAA']

4781 NM_001083962.1(TCF4):c.991- 6925 TCF4 ['TTTTTTTTTTCTCCTTATTGTTTTARGATCT 2A>G ATTCTCCAGATCACACTAAC]

4782 NM_178151.2(DCX):c.l027-2A>G 1641 DCX ['TTAACTTTGTCTCTTCTCTTCTTATRGGACC

TGTACCTGCCTCTGTCCTTG]

4783 NM_178151.2(DCX):c.607A>G 1641 DCX ['TGTGCGTGTGCTTCTGAACAAGAAGRCAG (p.Thr203Ala) CCCACTCTTTTGAGCAAGTCCT']

4784 NM_178151.2(DCX):c.538A>G 1641 DCX ['GGAGAACAAGGACTTTGTGCGCCCCRAGC (p.Lysl80Glu) TGGTTACCATCATCCGCAGTGG]

4785 NM_178151.2(DCX):c.520A>G 1641 DCX ['CAACAGTGCACAGGCCAGGGAGAACRAGG (p.Lysl74Glu) ACTTTGTGCGCCCCAAGCTGGT'] 4786 NM_178151.2(DCX):c.451A>G 1641 DCX ['CAATCCCAACTGGTCTGTCAACGTADAAA (p.Lysl51Glu) CATCTGCCAATATGAAAGCCCC]

4787 NM_178151.2(DCX):c.413A>G 1641 DCX ['GACAACTTCTTTAAAAAGGTGGAGTRCAC (p.Tyrl38Cys) CAAGAATGTCAATCCCAACTGG]

4788 NM_000252.2(MTMl):c.301A>G 4534 MTM1 ['AATTGAAAAAATGGGAGGCGCGACARGTA (p.SerlOlGly) GAGGAGAAAATTCCTATGGTCT']

4789 NM_000252.2(MTMl):c343- 4534 MTM1 ['ACTGTCATACTTCTCCTTTGCCCCCRGGAC 2A>G ATGAGAAACCTGAGGTTCGCT']

4790 NM_000252.2(MTMl):c529- 4534 MTM1 ['GACTTGAATTTCTTTTTTTCCTCACRGGGCT 2A>G TGCCCAATCACCATTGGAGA']

4791 NM_000252.2(MTMl):c.550A>G 4534 MTM1 ['ACAGGGCTTGCCCAATCACCATTGGRGAA (p.Argl84Gly) TAACTTTTATTAATAAGTGCTA']

4792 NM_000252.2(MTMl):c.629A>G 4534 MTM1 ['TTGGTGGTTCCGTATCGTGCCTCAGRTGAT (p.Asp210Gly) GACCTCCGGAGAGTTGCAACT']

4793 NM_000252.2(MTMl):c.1406A>G 4534 MTM1 ['CAATTTTTGATTATAATTTTGGATCRTCTGT (p.His469Arg) ATAGTTGCCGATTTGGTACT']

4794 NM_003159.2(CDKL5):c.62A>G 6792 CDKL5 ['TTTGAGATCCTTGGGGTTGTAGGTGRAGGT (p.Glu21Gly) AAGTTGGAATTTTTGCGTTCC]

4795 NM_006306.3(SMClA):c.3254A> 8243 SMC1A ['GTGGCTACCAACATTGATGAGATCTRTAA G (p.Tyrl085Cys) GGCCCTGTCCCGCAATAGCAGT']

4796 NM_006306.3(SMClA):c.616- 8243 SMC1A ['CCTGCCACCATTCCCCTGTTTGCACRGGCT 2A>G GACCGGTACCAGCGCCTGAAG]

4797 NM_003937.2(KYNU):c.592A>G 8942 KYNU ['GCCTAACTTGATTTAGGGGGAAGAARCCT (p.Thrl98Ala) TAAGAATAGAGGATATCCTTGA']

4798 NM_005343.2(HRAS):c.l82A>G -1 ['TTGGACATCCTGGATACCGCCGGCCNGGA (p.Gln61Arg) GGAGTACAGCGCCATGCGGGAC]

4799 NM_012275.2(IL36RN):c.l04A>G 26525 IL36RN ['CTAGCTGGAGGGCTGCATGCAGGGARGGT (p.Lys35Arg) CATTAAAGGTTGGTGATGAAAC]

4800 NM_152296.4(ATPlA3):c.2318A> 478 ATP 1 A3 ['TCCATTGCCTACACCCTGACCAGCADTATC G (p.Asn773Ser) CCGGAGATCACGCCCTTCCTG]

4801 NM_000891.2(KCNJ2):c.953A>G 3759 KCNJ2 ['CAGTGCCGTAGCTCTTATCTAGCAARTGAA (p.Asn318Ser) ATCCTGTGGGGCCACCGCTAT']

4802 NM_017909.3(RMNDl):c.713A>G 55005 RMND1 ['TACACTTACAGTTTTGTCTTTCACAYTCCA (p.Asn238Ser) AAACACAGCAGCTCCTTCCCT']

4803 NM_005154.4(USP8):c.2150A>G 9101 USP8 ['GAACCTTCCAAACTGAAGCGCTCCTDCTCC (p.Tyr717Cys) TCCCCAGATATAACCCAGGCT']

4804 NM_014191.3(SCN8A):c.667A>G 6334 SCN8A ['CAATGTTTCAGCTCTACGCACTTTCRGGGT (p.Arg223Gly) ACTGAGGGCTTTGAAAACTAT']

4805 NM_021830.4(C10orf2):c.l754A> 56652 C10orf2 ['CCCCAGGCAAGCCAGGAAGCAGACARTGT G (p.Asn585Ser) TCTGATCCTGCAGGACAGGAAG]

4806 NM_001164405.1 (BHLHA9) : c.211 72785 BHLHA9 ['GTCCAAGGCGCGGCGCATGGCCGCCRACG A>G (p.Asn71Asp) 7 TGCGGGAGCGCAAGCGCATCCT']

4807 NM_002887.3(RARS):c.5A>G 5917 RARS ['GAGTGAGACGCTGATGGGAGGATGGRCGT (p.Asp2Gly) ACTGGTGTCTGAGTGCTCCGCG] 4808 NM_002887.3(RARS):c.lA>G 5917 RARS ['TGGCGAGTGAGACGCTGATGGGAGGRTGG (p.MetlVal) ACGTACTGGTGTCTGAGTGCTC]

4809 NM_005861.3(STUBl):c. l94A>G 10273 STUB1 ['CCGCTGGTGGCCGTGTATTACACCARCCGG (p.Asn65Ser) GCCTTGTGCTACCTGAAGATG]

4810 NM_005211.3(CSFlR):c.2655- 1436 CSF1R ['ATGGGCATCCTCTGTCCTATCTCCCRGATA 2A>G CAGCATCATGCAGGCCTGCTG]

4811 NM_032228.5(FARl):c.1094 A>G 84188 FAR1 ['CATAAGGCCCCAGCATTCCTGTATGRTATC (p.Asp365Gly) TACCTCAGGATGACTGGAAGA']

4812 NM_020461.3(TUBGCP6):c.2546A 85378 TUBGCP6 ['GCCATCCCAGGCAGGCGAGTGTTGCYCTG >G (p.Glu849Gly) CAGACCCAGAATCACAGCCTTG]

4813 NM_014305.3(TGDS):c.269A>G 23483 TGDS ['TTTGTGAAACTGCTTTTTGAAACAGRGAAA (p.Glu90Gly) ATAGATATAGTACTACATTTT']

4814 NM_014305.3(TGDS):c.892A>G 23483 TGDS ['TCTGTTTTGTTTTCCAAGACCCACCRATGA (p.Asn298Asp) CATGAGATACCCAATGAAGTC]

4815 NM_000118.3 (ENG) : c.1273 -2 A>G 2022 ENG ['GCTCGACAGGATATTGACCACCGCCYGCG

GGGATAAAGCCAGGGAGCTGGT']

4816 NM_005360.4(MAF):c.l72A>G 4094 MAF ['CATCGCCGGGGGCTCGCTGTCCTCCRCCCC (p.Thr58Ala) CATGAGCACGCCGTGCAGCTC]

4817 NM_002238.3(KCNHl):c.l399A> 3756 KCNH1 ['ACCTCTAGCACTTCTCTATGCCACCRTCTT G (p.Ile467Val) CGGGAATGTGACGACTATTTT']

4818 NM_172362.2(KCNHl):c.l508A> 3756 KCNH1 ['TTCGGGAATGTGACGACTATTTTCCRACAG G (p.Gln503Arg) ATGTATGCCAACACCAACAGA']

4819 NM_003392.4(WNT5A):c.257A>G 7474 WNT5A ['GGACAGAAGAAACTGTGCCACTTGTRTCA (p.Tyr86Cys) GGACCACATGCAGTACATCGGA']

4820 NM_001199252.2(SGOLl):c.67A> -1 ['GCCAAGTTTTTATTCCTTTTCTCTTYCATTC G (p.Lys23Glu) GCTTCTTTATGTCTTCAAGA']

4821 NM_000256.3(MYBPC3):c.2906- 4607 MYBPC3 ['ACTTAGCTACCCACTCTATACCCACRGAAC 2A>G GGCCACGGCTTCAGCTGCCCA']

4822 NM_000256.3(MYBPC3):c.l213A 4607 MYBPC3 ['GCTCAAGAATGGCCAGGAGATCCAGRTGA >G (p.Met405Val) GCGGCAGGTGCAGCCTGGGGTG]

4823 NM_005188.3(CBL):c.l228-2A>G 867 CBL ['TGTTACTATCTTTTGCTTCTTCTGCRGGAAT

CAGAAGGTCAGGGCTGTCCT']

4824 NM_000257.3(MYH7):c.5326A>G 4625 MYH7 ['TTCTTCATGCGCTCCAGGTGGGCGCYGGTG (p.Serl776Gly) TCCTGCTCCTTCTTCAGCTCC]

4825 NM_000257.3(MYH7):c.2708A>G 4625 MYH7 ['CAAGACAACCTGGCAGATGCTGAGGRGCG (p.Glu903Gly) CTGTGATCAGCTGATCAAAAAC]

4826 NM_000257.3(MYH7):c. l727A>G 4625 MYH7 ['AATATCAAGGGGAAGCCTGAAGCCCRCTT (p.His576Arg) CTCCCTGATCCACTATGCCGGC]

4827 NM_000257.3(MYH7):c. l496A>G 4625 MYH7 ['CACCACATGTTTGTGCTGGAGCAGGRGGA (p.Glu499Gly) GTACAAGAAGGAGGGCATCGAG]

4828 NM_000257.3(MYH7):c.2539A>G 4625 MYH7 ['GCTGCTGAAGAGTGCAGAAAGAGAGRAGG (p.Lys847Glu) AGATGGCCTCCATGAAGGAGGA]

4829 NM_000257.3(MYH7):c. l954A>G 4625 MYH7 ['CTTTCAGACTGTGTCAGCTCTGCACRGGGT (p.Arg652Gly) GAGTGGGACACAGCCCCAGCC] 4830 NM_000257.3(MYH7):c. ll57A>G 4625 MYH7 ['CTTCCAGAGGCTGACAAGTCTGCCTRCCTC (p.Tyr386Cys) ATGGGGCTGAACTCAGCCGAC]

4831 NM_000501.3(ELN):c.800-2A>G 2006 ELN ['TACATTGCACTGTCCCCATCTCAACRGGTG

CTGGAGCAGCCGGAGTCCTCC]

4832 NM_000117.2(EMD):c.266-2A>G 2010 EMD ['TCTGCTACCGCTGCCCCCCTTCCCARGGCT

ACAATGACGACTACTATGAAG]

4833 NM_000191.2(HMGCL):c.698A>G 3155 HMGCL ['GTGCCTCTGGCTGCCCTGGCTGTCCRCTGC (p.His233Arg) CATGACACCTATGGTCAAGCC]

4834 NM_207352.3(CYP4V2):c.l393A> 28544 CYP4V2 ['CTACGTGCCCTTCTCTGCTGGCCCCRGGAA G (p.Arg465Gly) 0 CTGTATAGGTTTGTATCCATC]

4835 NM_013382.5(POMT2):c.l726- 29954 POMT2 ['GTCAGCAGGGTGGTCTCTATTCCACRGGGC 2A>G CTACGCTTCTCAGGGGTCAAT']

4836 NM_000169.2(GLA):c.802-2A>G -1 ['TTTGAATTATTTCATTCTTTTTCTCRGTTAG

TGATTGGCAACTTTGGCCTC']

4837 NM_020166.4(MCCCl):c.l37- 56922 MCCC1 ['GTGTGATTTTCATGGTGTTTTAAACRGGAA 2A>G GAAACATTACCAAGGTCCTCA']

4838 NM_006920.4(SCNlA):c.2557- 6323 SCN1A ['AATATATATTAATCTTTCATTTTCCRGCTG 2A>G CGAGTTTTCAAGTTGGCAAAA']

4839 NM_000501.3(ELN):c.890-2A>G 2006 ELN ['CCTCACCCTCTGTGGCTGTGTTTTCRGGCG

TTGGGACTCCAGCTGCAGCTG]

4840 NM_006306.3(SMClA):c.2974- 8243 SMC1A ['TGACATTGCTGGGCCTGGGGCTTACRGGAT 2A>G GCCCAGGCTGAGGAAGAGATC]

4841 NM_001110792.1(MECP2):c.520A 4204 MECP2 ['TGATTTTGACTTCACGGTAACTGGGRGAGG >G (p.Argl74Gly) GAGCCCCTCCCGGCGAGAGCA]

4842 M_004646.3(NPHSl):c.l756A>G 4868 NPHS1 ['CTTGTCCTGGGACAAGGAAGGGGAGRGGT (p.Arg586Gly) GGGAGTGCGAGGGATCCCTCCC]

4843 NM_003002.3(SDHD):c.275A>G 6392 SDHD ['TATTTGAATCCTTGCTCTGCGATGGRCTAT (p.Asp92Gly) TCCCTGGCTGCAGCCCTCACT']

4844 NM_004793.3(LONPl):c.2353A>G 9361 LONP1 ['CACGCTGTTTGTGGAGACATCCCTGRGACG (p.Arg785Gly) GCCACAGGACAAGGATGCCAA]

4845 NC_012920.1 :m.4279A>G 4565 MT-TI ['TCAAACCTAAGAAATATGTCTGATARAAG

AGTTACTTTGATAGAGTAAATA]

4846 NM_005633.3(SOSl):c.l430A>G 6654 SOS1 ['ATTTGCTGTAAATCAAATCATGGGCRGCCA (p.Gln477Arg) AGACTTCCTGGTGCTAGCAAT']

4847 NM_000256.3(MYBPC3):c.l227- 4607 MYBPC3 ['TGCCACTTCCCTGCGGCCCCCACCCRGGTA 2A>G CATCTTTGAGTCCATCGGTGC]

4848 NM_002834.3(PTPNl l):c.661A>G 5781 PTPN11 ['CGATCAGCCCCTTAACACGACTCGTDTAA (p.Ile221Val) ATGCTGCTGAAATAGAAAGCAG]

4849 NM_000257.3(MYH7):c.4664A>G -1 ['TCCCAGGCCTCCCTGGAGCACGAGGRGGG (p.Glul555Gly) CAAGATCCTCCGGGCCCAGCTG]

4850 NM_000257.3(MYH7):c.2792A>G 4625 MYH7 ['AACGAGAGGCTGGAGGATGAGGAGGRGA (p.Glu931Gly) TGAATGCTGAGCTCACTGCCAAG]

4851 NM_000257.3(MYH7):c.2087A>G 4625 MYH7 ['CTGGTCATGCACCAGCTGCGCTGCARTGGT (p.Asn696Ser) GTGCTGGAGGGCATCCGCATC] 4852 NM_000257.3(MYH7):c. l805A>G 4625 MYH7 ['CTGCAGAAGAACAAGGATCCTCTCARTGA (p.Asn602Ser) GACTGTCGTGGGCTTGTATCAG]

4853 NM_000257.3(MYH7):c. l615A>G 4625 MYH7 ['CATGTCCATCCTGGAAGAGGAGTGCRTGTT (p.Met539Val) CCCCAAGGCCACCGACATGAC]

4854 NM_000257.3(MYH7):c. l477A>G 4625 MYH7 ['GCTGCAGCAGTTCTTCAACCACCACRTGTT (p.Met493Val) TGTGCTGGAGCAGGAGGAGTA']

4855 NM_000257.3(MYH7):c. l331A>G 4625 MYH7 ['TTCAACTGGATGGTGACGCGCATCAVTGC (p.Asn444Ser) CACCCTGGAGACCAAGCAGCCA']

4856 NM_000257.3(MYH7):c. l315A>G 4625 MYH7 ['AGGGTGGCATTGATGCGCGTCACCAHCCA (p.Met439Val) GTTGAACATCCTCTCATACACT']

4857 NM_000257.3(MYH7):c. l051A>G 4625 MYH7 ['TTCAGAGGAGAAAAACTCCATGTATRAGC (p.Lys351Glu) TGACAGGCGCCATCATGCACTT']

4858 NM_000257.3(MYH7):c.789A>G 4625 MYH7 ['CAGGAAAGTTGGCATCTGCAGACATRGAG (p.Ile263Met) ACCTGTGAGTGCCATGAATCTG]

4859 NM_000257.3(MYH7):c.617A>G 4625 MYH7 ['ATTGCAGCCATTGGGGACCGCAGCARGAA (p.Lys206Arg) GGACCAGAGCCCGGGCAAGGTA']

4860 NM_000363.4(TNNI3):c.616A>G 7137 TNNI3 ['ACTGAGTGGAATGGAGGGCCGCAAGVAAA (p.Lys206Glu) AGTTTGAGAGCTGAGCCTTCCT']

4861 NM_000363.4(TNNI3):c.547A>G 7137 TNNI3 ['GCAGGTGAAGAAGGAGGACACCGAGRAG (p.Lysl83Glu) GTGAGTGTGGGCTAAGGCCAGGA']

4862 NM_000169.2(GLA):c.370-2A>G -1 ['TGACTCTTTTCCTCCCTCTCATTTCRGGTTC

ACAGCAAAGGACTGAAGCTA']

4863 NM_000051.3(ATM):c.lA>G 472 ATM ['GATGTGTGTTCTGAAATTGTGAACCVTGAG (p.MetlVal) TCTAGTACTTAATGATCTGCT']

4864 NM_000051.3(ATM):c.3154-2A>G 472 ATM ['TATTTAACCACAGTTCTTTTCCCGTRGGCT

GATCCTTATTCAAAATGGGCC]

4865 NM_024675.3(PALB2):c.212- 79728 PALB2 ['AGTTATATACATTTTTTTCCTCCTCRGAAC 2A>G CTAAAAATAAAATATGTGTTT']

4866 NM_024675.3(PALB2):c. l09- 79728 PALB2 ['TTCTGGGGCTGTTTTTGTCTCCTCTRGCGTG 2A>G CCCAAAGAGCTGAAAAGATT']

4867 NM_000546.5(TP53):c.709A>G 7157 TP53 ['CTGTACCACCATCCACTACAACTACRTGTG (p.Met237Val) TAACAGTTCCTGCATGGGCGG]

4868 NM_000455.4(STKl l):c.889A>G 6794 STK11 ['GATGCTTGAGTACGAACCGGCCAAGRGGT (p.Arg297Gly) TCTCCATCCGGCAGATCCGGCA]

4869 NM_017777.3(MKSl):c.l382A>G 54903 MKS1 ['TCTCTGGAACTGGAGGACCTCTCCTRTGTA (p.Tyr461Cys) CGGATACCAGGATCCTTCAAG]

4870 NM_001231.4(CASQl):c.731A>G 844 CASQ1 ['ATGGAAGAGCCTGTGACCATCCCAGRCAA (p.Asp244Gly) GCCCAATAGCGAAGAGGAGATT']

4871 NM_001242896.1(DEPDC5):c.235 9681 DEPDC5 ['GTATGAGCAATCATCTGTTGTTTTCRGGAG 5-2A>G (p.Arg785_Gly839del) GGACGAAGATGGTGTGCAGAT']

4872 NM_001039550.1(DNAJB2):c. l4A 3300 DNAJB2 ['TGACCAGTTGCCATGGCATCCTACTRCGAG >G (p.Tyr5Cys) ATCCTAGACGTGCCGCGAAGT']

4873 NM_007294.3(BRCAl):c.5057A> 672 BRCA1 ['AATCTAATTACTGAAGAGACTACTCRTGTT G (p.Hisl686Arg) GTTATGAAAACAGGTATACCA] 4874 NM_006888.4(CALMl):c.389A>G 801 CALM1 ['GTAGATGAAATGATCAGAGAAGCAGRTAT (p.Aspl30Gly) TGATGGAGACGGACAAGTCAAC]

4875 NM_001082538.2(TCTNl):c.342- 79600 TCTN1 ['TTGTATTATTATTTTTTTAATTTTCRGGGGC 2A>G GACAGCCAGTTTTGTAGTCA']

4876 NM_003000.2(SDHB):c.541-2A>G 6390 SDHB ['TCCTGCCTCTCTTTTCTCCCCATACRGGAC

GGGCTCTACGAGTGCATTCTC]

4877 NM_000143.3(FH):c.700A>G 2271 FH ['AGTGGAACAGCATCCTGAGTATGAGYACG (p.Thr234Ala) TCCAATCTTGATGATCTGTGCA]

4878 NM_000038.5(APC):c.221-2A>G 324 APC ['ATAAAAACTTGTTTCTATTTTATTTRGAGC

TTAACTTAGATAGCAGTAATT']

4879 NM_000314.6(PTEN):c.527A>G 5728 PTEN ['ATTCCCAGTCAGAGGCGCTATGTGTRTTAT (p.Tyrl76Cys) TATAGCTACCTGTTAAAGAAT']

4880 NM_030813.5(CLPB):c.l850A>G 81570 CLPB ['CTGGTCGACGGCTACAATGTGCACTRTGGC (p.Tyr617Cys) GCCCGCTCCATCAAACATGAG]

4881 NM_030813.5(CLPB):c.l222A>G 81570 CLPB ['TCCTGGAACTCGGACATGTCCAGCCHGAT (p.Arg408Gly) GAAGCCCTGTGTGGAAACAAGC]

4882 NM_016069.9(PAM16):c.226A>G -1 ['CTCACCCGTCCCCTCTCCTCTGCAGRACTA (p.Asn76Asp) TGAACACTTATTTAAGGTGAA]

4883 NM_058163.1(TSR2):c. l91A>G 90121 TSR2 ['TACTTAGCTGACTTGGAGCTAGATGRGGTG (p.Glu64Gly) GAAGACTTCCTTGGAGAGCTG]

4884 NM_001031.4(RPS28):c.lA>G 6234 RPS28 ['ATAGGCTGCACACGGCTGGTGTCCAYGAT (p.MetlVal) GGCGGCGCGGCGGCGGTCTGGC]

4885 NM_005957.4(MTHFR):c.1114A> 4524 MTHFR ['TCCCATCTTCTGGGCCTCCAGACCARAGAG G (p.Lys372Glu) TTACATCTACCGTACCCAGGA]

4886 M_014946.3(SPAST):c.l l65A>G 6683 SPAST ['CTTTGGTCCACCTGGGAATGGGAAGRCAA (p.Thr389Ala) TGCTGGTAAGGGTTCTCTTCAA']

4887 NM_000228.2(LAMB3):c.565- 3914 LAMB3 ['TAAATCCATAAGGTTAAGTTGGACCYACA 2A>G GAGGGAAGGGAAAGAGAAGCGC]

4888 NM_000492.3(CFTR):c.3368- 1080 CFTR ['TCATTTACGTCTTTTGTGCATCTATDGGAG 2A>G AAGGAGAAGGAAGAGTTGGTA']

4889 NM_006785.3(MALTl):c. l019- 10892 MALT1 ['AACACCCCCTTTCTTTTTTTTTCAARGCGA 2A>G AGGACAAGGTTGCCCTTTTGA']

4890 NM_004771.3(MMP20):c.611A>G 9313 MMP20 ['GGAGAAGGCCTGGGAGGAGATACACRTTT (p.His204Arg) CGACAATGCTGAGAAGTGGACT']

4891 NM_000918.3(P4HB):c.l l78A>G 5034 P4HB ['CACCCTAGAACTGCTTTCTTTTCAGRTGCC (p.Tyr393Cys) CCATGGTGTGGTCACTGCAAA']

4892 NM_177405.2(CECRl):c.355A>G 51816 CECR1 ['TGCTCGCATCCCGCAGGCTCACCTGYTTCT (p.Thrl l9Ala) CCGGCGTGGAAGAAGTAAGGC]

4893 NM_004990.3(MARS):c.l031A>G 4141 MARS ['TACCACATCATCCATGCTGACATCTRCCGC (p.Tyr344Cys) TGGTTTAACATTTCGTTTGAT']

4894 NM_025132.3(WDR19):c.407- 57728 WDR19 ['TCTGTATAAAAATAATCTCTTTTTCRGGAA 2A>G AACATACTAAGAGAATCACTT']

4895 NM_000314.6(PTEN):c.l39A>G 5728 PTEN ['TGCAGAAAGACTTGAAGGCGTATACRGGA (p.Arg47Gly) ACAATATTGATGATGTAGTAAG] 4896 NM_000314.6(PTEN):c.l82A>G 5728 PTEN ['GTTTTAAGGTTTTTGGATTCAAAGCDTAAA (p.His61Arg) AACCATTACAAGATATACAAT']

4897 NM_000314.6(PTEN):c.254-2A>G 5728 PTEN ['TATTCTGAGGTTATCTTTTTACCACRGTTG

CACAATATCCTTTTGAAGACC]

4898 NM_000314.6(PTEN):c.320A>G 5728 PTEN ['GAACTTATCAAACCCTTTTGTGAAGRTCTT (p.Aspl07Gly) GACCAATGGCTAAGTGAAGAT']

4899 NM_000314.6(PTEN):c.512A>G 5728 PTEN ['CACCAGGGAGTAACTATTCCCAGTCRGAG (p.Glnl71Arg) GCGCTATGTGTATTATTATAGC]

4900 NM_000314.6(PTEN):c.802-2A>G 5728 PTEN ['TTTTCTTTTCTTTTTTTTTTTTTTTDGGACAA

AATGTTTCACTTTTGGGTA']

4901 NM_001103.3(ACTN2):c. l883A> 88 ACTN2 ['ATCCGCGATCAATCCCTGCAGGAGGRGCT G (p.Glu628Gly) GGCTCGCCAGCATGCTAACGAG]

4902 NM_003159.2(CDKL5):c.-162- 6792 CDKL5 ['GCTTTTAATTGTGTTTGTTTTTTTCRGGGAG 2A>G TCATTTAATACTTCATGATT']

4903 NM_003159.2(CDKL5):c.91A>G 6792 CDKL5 ['AGCCTATGGAGTTGTACTTAAATGCRGAC (p.Arg31Gly) ACAAGGCAAGTACATTATTTTT']

4904 NM_003159.2(CDKL5):c.458A>G 6792 CDKL5 ['CACAATGATGTCCTAAAACTGTGTGRCTTT (p.Aspl53Gly) GGTAAGTTAAAAAGAAATTAA']

4905 NM_003159.2(CDKL5):c.2277- 6792 CDKL5 ['ATATGATAAAAATGTCTTCTCATTTRGGAA 2A>G AAGTCCTGAAAATATTAGTCA']

4906 NM_021098.2(CACNAlH):c.4645 8912 CACNA1H ['CATCGTCAGCTTCTTCGTGCTCAACRTGTT A>G (p.Metl549Val) CGTGGGC GTC GTGGTC GAG A A']

4907 NM_003816.2(ADAM9):c.l396- 8754 ADAM9 ['TGTTTAATTTGAATTCTATTTCACTRGTTCC 2A>G TTCCAGGAGGTACTTTATGC]

4908 NM_212472.2(PRKARlA):c.177+3 5573 PRKARIA ['AATACTTTGAGAGGTTGGAGAAGGTRAAA A>G ATAAATGTGGGGAGATGATGAG]

4909 NM_001204830.1(LIPTl):c.535A> -1 ['CCGGACTACTGCCTATCACCATTGCRCTTT G (p.Thrl79Ala) ATTATGTAGTACTGATGGGAC]

4910 NM_001165963.1(SCNlA):c.5264 -1 ['AACCCTGGAAGCTCAGTTAAGGGAGRCTG A>G (p.Aspl755Gly) TGGGAACCCATCTGTTGGAATT']

4911 NM_001165963.1(SCNlA):c.3880- -1 ['TAATTGTTATTATTTTTGTGTGTGCRGGTTT 2A>G CATTGGTCAGTTTAACAGCA']

4912 NM_001165963.1(SCNlA):c.2537 6323 SCN1A ['TTTATTGTGACGCTTAGCCTGGTAGRACTT A>G (p.Glu846Gly) GGACTCGCCAATGTGGAAGGA']

4913 NM_001165963.1(SCNlA):c.2353 6323 SCN1A ['GTCATTGGATAGTGCTCCATGGCCAHGAA A>G (p.Met785Val) AAGAGTATTTAAGACAATACAG]

4914 NM_001165963.1(SCNlA):c.l662 6323 SCN1A ['AGAGGTACTCCTCCCCACACCAGGTRTGG

+3A>G CACTGCTGAGTTTACTGATGCA']

4915 NM_001165963.1(SCNlA):c.l076 6323 SCN1A ['TGTGTGAAAGCTGGTAGAAATCCCADTTA A>G (p.Asn359Ser) TGGCTACACAAGCTTTGATACC]

4916 NM_001165963.1(SCNlA):c.l048 6323 SCN1A ['TTGCAGCCAATGTCCAGAGGGATATRTGT A>G (p.Met350Val) GTGTGAAAGCTGGTAGAAATCC]

4917 NM_001165963.1(SCNlA):c.l046 6323 SCN1A ['ACTTGCAGCCAATGTCCAGAGGGATRTAT A>G (p.Tyr349Cys) GTGTGTGAAAGCTGGTAGAAAT'] 4918 NM_001165963.1(SCNlA):c.433A 6323 SCN1A ['CACTATTTTGACAAACTGTGTGTTTRTGAC >G (p.Metl45Val) AATGAGTAACCCTCCTGATTG]

4919 NM_001165963.1(SCNlA):c.383+ 6323 SCN1A ['TAGCTATTAAGATTTTGGTACATTCRTATC 1A>G CTTTTTCAAGTGATTAATATT']

4920 NM_001605.2(AARS):c.2251A>G 16 AARS [TCGGCACCTGTGACAGCCACAATCCYCCG (p.Arg751Gly) GATACCCTTGGCAATGGCTTCT']

4921 NM_000124.3(ERCC6):c.2830- 2074 ERCC6 ['TATTCTCCATGCTCGCTCCCGGGCCYGCAA 2A>G CAGAGAGAGAGAGACCTCTCA']

4922 NM_000124.3(ERCC6):c.2599- 2074 ERCC6 ['ACTGGGAATGTGTATTTGCTTTGCAVACTC 26A>G CTATCCCCCACCTCCAAACAG]

4923 NM_001110556.1(FLNA):c. l829- 2316 FLNA ['ACTGAGGGGACTGGTGGCTGTTGTCRGGC 2A>G TTCTCGGTGGAAGGGCCATCGC]

4924 NM_006129.4(BMPl):c.808A>G 649 BMP1 ['GGAGACCTATGACTTCGACAGCATCRTGC (p.Met270Val) ATTACGCTCGGAACACATTCTC]

4925 NM_001987.4(ETV6):c.l252A>G 2120 ETV6 ['GGAGCCAGGACAAAGGCTTTTGTTCRGGT (p.Arg418Gly) AGCACTTCCTTTTTCTCCTTTC]

4926 NM_014423.3(AFF4):c.760A>G 27125 AFF4 ['GTCCAATTCAATGTTACAGAAACCCRCTGC (p.Thr254Ala) CTATGTGCGGCCCATGGACGG]

4927 NM_002055.4(GFAP):c.l085A>G 2670 GFAP ['AATGTCAAGCTGGCCCTGGACATCGRGAT (p.Glu362Gly) CGCCACCTACAGGAAGCTGCTA']

4928 NM_002055.4(GFAP):c.256A>G 2670 GFAP ['TGACCGCTTTGCCAGCTACATCGAGRAGGT (p.Lys86Glu) TCGCTTCCTGGAACAGCAAAA']

4929 NM_006017.2(PROMl):c.2077- 8842 PROM1 ['ATTTGCTGTTCTTCACAGCTTTAGGRTATG 521A>G TATCCAATGTTTTCTTCAGGT']

4930 NM_002755.3(MAP2Kl):c.305A> 5604 MAP2K1 ['ACCTTTCTCCAGCTAATTCATCTGGRGATC G (p.Glul02Gly) AAACCCGCAATCCGGAACCAG]

4931 NM_001288953.1(TTC7A):c. l715 57217 TTC7A ['CGTCCCCACAGCCTGATGTTCACCARGGTG A>G (p.Lys572Arg) AAGCTGGAGCAGGTGCTGAAA']

4932 NM_016218.2(POLK):c. l81A>G 51426 POLK ['TGAGCTCAAGAAAGAAAAGCAAGTCRACC (p.Asn61Asp) AACGAATTGAAAATATGATGCA']

4933 NM_016218.2(POLK):c. l385A>G 51426 POLK ['AGAACTGTTACCATTAAGTTGAAGARTGT (p.Asn462Ser) GAATTTTGAAGTAAAAACTCGT']

4934 NM_016218.2(POLK):c. l477A>G 51426 POLK ['ATTTGCCATTGCTAAGGAATTGCTARAAAC (p.Lys493Glu) AGAAATTGATGCTGATTTTCC]

4935 NM_001040431.2(COA3):c.215A> 28958 COA3 ['GGAAATCGAGTAGAAGGTGTAACCAYCTG G (p.Tyr72Cys) GGGAGGTAGGTTCAGGAAACCA']

4936 NM_000891.2(KCNJ2):c.901A>G 3759 KCNJ2 ['TGAAATCGTGGTCATACTGGAAGGCRTGG (p.Met301Val) TGGAAGCCACTGCCATGACGAC]

4937 M_144499.2(GNATl):c.386A>G 2779 GNAT1 ['GACATCATCCAGCGGCTGTGGAAGGRCTC (p.Aspl29Gly) CGGTATCCAGGCCTGTTTTGAG]

4938 NM_018965.3 (TREM2) :c .113 A>G 54209 TREM2 ['CAGTCCCTGCAGGTGTCTTGCCCCTRTGAC (p.Tyr38Cys) TCCATGAAGCACTGGGGGAGG]

4939 NM_194277.2(FRMD7):c.556A>G 90167 FRMD7 ['ACTGGACATAGCAAGGAAGCTGGATRTGT (p.Metl86Val) ATGGCATCAGGCCTCACCCCGC] 4940 NM_001003811.1(TEXl l):c.511A 56159 TEX11 ['TCACTCTCAACAGTAATCTTCTCCAYGGTC >G (p.Metl71Val) AAGTCAGCCTCAGGGGAGCTC]

4941 NM_000921.4(PDE3A):c. l333A>G 5139 PDE3A ['AGTTTCTTCCACTTGGACCACCACCRCCTC (p.Thr445Ala) GGCCACAGGTCTACCCACCTT']

4942 NM_000033.3(ABCDl):c.887A>G 215 ABCD1 ['GCCAACTCGGAGGAGATCGCCTTCTRTGG (p.Tyr296Cys) GGGCCATGAGGTGGGGCAGGTT']

4943 NM_000169.2(GLA):c. l37A>G -1 ['AGGACGCCTACCATGGGCTGGCTGCDCTG (p.His46Arg) GGAGCGCTTCATGTGCAACCTT']

4944 NM_000033.3(ABCDl):c.l992- 215 ABCD1 ['CCCTGACCCTGTCCCTCTCCTGGCCRGGAA 2A>G ATACCACACACACTTGCTACA']

4945 NM_000182.4(HADHA):c.919- 3030 HADHA ['TTGCTCAATTCCAGTCTTTACCACCYAAAA 2A>G AACATATAAAGCACTTGCTCA']

4946 NM_000159.3(GCDH):c.l213A>G 2639 GCDH ['CGAGTATCACGTGATCCGGCACGCCRTGA (p.Met405Val) ACCTGGAGGCCGTGAACACCTA']

4947 NM_004006.2(DMD):c.1150-2A>G 1756 DMD ['ACAATTGTTAACTTCCTTCTTTGTCRGGGG

TACATGATGGATTTGACAGCC]

4948 NM_019109.4(ALGl):c. l l88- 56052 ALG1 ['CTCAGGCTCCCTTGGTTCTCTCTGCRGTTT 2A>G ACATGAGCTGGTGAAACATGA']

4949 NM_004463.2(FGDl):c.2016- 2245 FGD1 ['TCTTTCTTTTTTATTCCCCACCCCARGGACT 2A>G GAGGAGGAGAAGAAAGACTG]

4950 NM_198525.2(KIF7):c.2981A>G 37465 KIF7 ['CTGCTGCTGGCTCTGGGCGCTGCCCYGCCG (p.Gln994Arg) 4 CAGCTGCCCGCTCTTCTCGGA']

4951 NM_020366.3(RPGRIPT):c.3749- 57096 RPGRIP1 ['ATGCTGTTTTTTTCCCTTTCCCAACRGTTGT 2A>G TAGCCCTGAAGATCTGGCTA']

4952 M_003494.3(DYSF):c.3041A>G 8291 DYSF ['GTTCCCCCTCCCCCAGGCTGGGAGTRTAGC (p.Tyrl014Cys) ATCACCATCCCCCCGGAGCGG]

4953 NM_003494.3(DYSF):c.3349- 8291 DYSF ['CTGCCATAACCAGCTTCGTGTCTCCRGGGC 2A>G GGCGTGATGGATGACAAGAGT']

4954 NM_004006.2(DMD):c.4675-2A>G 1756 DMD ['ATTACATTTCATTATAATTCTTTTCRGGTA

ACAGAAAGAAAGCAACAGTTG]

4955 NM_000169.2(GLA):c.620A>G -1 ['GTGTACTCCTGTGAGTGGCCTCTTTRTATG (p.Tyr207Cys) TGGCCCTTTCAAAAGGTGAGA']

4956 NM_022124.5(CDH23):c.l46- -1 ['CTCTGCTCTCTCCCTTGGCTACTCCRGGTTC 2A>G TTCTGTGACCCAGTTGCTGG]

4957 NM_000169.2(GLA):c.801+3A>G -1 ['GGGGTTGGAATGACCCAGATATGGTRAAA

ACTTGAGCCCTCCTTGTTCAAG]

4958 NM_000019.3(ACATl):c.473A>G 38 AC ATI ['GCAGGTGGGATGGAGAGCATGTCCARTGT (p.Asnl58Ser) TCCATATGTAATGAACAGAGGA]

4959 NM_000553.4(WRN):c.561A>G 7486 WRN ['GTCTGGTTAAACACCTCTTAGGTAARCAGC (p.Lysl87=) TCCTGAAAGACAAGTCTATCC]

4960 NM_000050.4(ASSl):c.421-2A>G 445 ASS1 ['GGCTCTGACCCCTTGTCCTATGTCCDGGTC

ATTGCTCCCTGGAGGATGCCT']

4961 NM_020166.4(MCCCl):c.640- 56922 MCCC1 ['TTCTGATCTAACAATCCTCATTCCCYAAGA 2A>G GAGAAAAGATGATTATGACTA'] 4962 NM_004006.2(DMD):c.10554- 1756 DMD ['TCTTTTTTACTTTTTTGATGCCAATRGGAAT 2A>G CTGCAAGCAGAATATGACCG]

4963 NM_017653.3(DYM):c.621-2A>G 54808 DYM ['ACAAGTTTGCTGGTGTATGGAAGACYATA

CAAAAAGGAAAAAAAAATCAAA']

4964 NM_001098398.1(COPA):c.728A> -1 ['TCAGAATCAAAGGCATGGGAGGTTGRTAC G (p.Asp243Gly) CTGCCGGGGCCATTACAACAAT']

4965 NM_005045.3(RELN):c.2288A>G 5649 RELN ['CGTCAGCTAATTACATCTTTCCTTGRCAGC (p.Asp763Gly) TCACAATCCAGGTGAGTGAAG]

4966 NM_207111.3(RNF216):c.l616A> 54476 RNF216 ['TGCCATCTCTTTGATTTTCTGCTCAHAGAA G (p.Tyr539Cys) CTCCTGCTCTTGTTGCACAGC]

4967 NM_001035.2(RYR2):c.568A>G 6262 RYR2 ['CATCTTAGTTAGCGTGTCCTCTGAARGGTA (p.Argl90Gly) CTTGGTAAGTGTGGAAAGTAG]

4968 NM_001035.2(RYR2):c.l l965A>G 6262 RYR2 ['AAATGCAACTGCTTTACCACCAGGTVATGT (p.Asn3989Asp) TGTTAATGGAACGATTGGCAA']

4969 NM_001035.2(RYR2):c.l2290A>G 6262 RYR2 ['GAACCTGCGAAGGACATCGGCTTCARCGT (p.Asn4097Ser) CGCCGTCCTTCTGACAAACCTC]

4970 NM_001035.2(RYR2):c.l2533A>G 6262 RYR2 ['AGACAGTTCATATTTGACGTGGTCARCGA (p.Asn4178Ser) AGGCGGAGAGAAAGAGAAGATG]

4971 NM_000090.3(COL3Al):c.2338- 1281 COL3A1 ['ACAGTGACATGGCTTCTCTTTTTCCRGGGT 2A>G GAAGGTGGTGCCCCCGGACTT']

4972 NM_198056.2(SCN5A):c.4462A>G 6331 SCN5A ['CTTAGGGGGCCAGGACATCTTCATGRCAG (p.Thrl488Ala) AGGAGCAGAAGAAGTACTACAA']

4973 NM_198056.2(SCN5A):c.4453A>G 6331 SCN5A ['CTCTTTGCACTTAGGGGGCCAGGACRTCTT (p.Ilel485Val) CATGACAGAGGAGCAGAAGAA']

4974 NM_198056.2(SCN5A):c.2788- 6331 SCN5A ['GGTGAGCCTGACCCATTATCTCGACRGGTC 2A>G CTGAATCTCTTCCTGGCCTTG]

4975 NM_198056.2(SCN5A):c. l247A>G 6331 SCN5A ['GATGGTGGCTTGGTTTTGCTCCTCAYAGGC (p.Tyr416Cys) CATTGCGACCACGGCCAGGAT']

4976 M_004415.2(DSP):c.l l41-2A>G 1832 DSP ['TTCACTGATCACTCTCATCCTTCACRGTTTT

TTGAAGAGGCGCAGTCTACT']

4977 NM_000238.3(KCNH2):c.2582A> 3757 KCNH2 ['TGGTCCAGCCTGGAGATCACCTTCANCCTG G (p.Asn861Ser) CGAGATGTGAGTTGGCTGCCC]

4978 NM_000238.3(KCNH2):c.l913A> 3757 KCNH2 ['GTCTCTCCCAACACCAACTCAGAGARGAT G (p.Lys638Arg) CTTCTCCATCTGCGTCATGCTC]

4979 NM_000238.3 (KCNH2) :c .1904 A> 3757 KCNH2 ['TTCGGCAACGTCTCTCCCAACACCADCTCA G (p.Asn635Ser) GAGAAGATCTTCTCCATCTGC]

4980 NM_000238.3 (KCNH2) :c .1900 A> 3757 KCNH2 ['GGGCTTCGGCAACGTCTCTCCCAACRCCAA G (p.Thr634Ala) CTCAGAGAAGATCTTCTCCAT']

4981 NM_000238.3(KCNH2):c.l l29- 3757 KCNH2 ['CCACACCTCCGCCTTCCCCGGGTGCRGGTC 2A>G CTGTCCCTGGGCGCCGACGTG]

4982 NM_000238.3(KCNH2):c.296A>G 3757 KCNH2 ['GAGCGCAAAGTGGAAATCGCCTTCTVCCG (p.Tyr99Cys) GAAAGATGGTAGGAGCGGGCCG]

4983 NM_000238.3 (KCNH2) :c .133 A>G 3757 KCNH2 ['GGAGAACTGCGCCGTCATCTACTGCDACG (p.Asn45Asp) ACGGCTTCTGCGAGCTGTGCGG] 4984 NM_001613.2(ACTA2):c. lA>G 59 ACTA2 ['AGAATCCTGTGAAGCAGCTCCAGCTRTGT (p.MetlVal) GTGAAGAAGAGGACAGCACTGC]

4985 NM_000218.2(KCNQl):c.605A>G 3784 KCNQ1 ['GCTCCCCCTCTCCTGCACTCCACAGRCCTC (p.Asp202Gly) ATCGTGGTCGTGGCCTCCATG]

4986 NM_000218.2(KCNQl):c.l033- 3784 KCNQ1 ['GGGAGCCTCCTGTCCATTCCTTCCCVGGGG 2A>G ATTCTTGGCTCGGGGTTTGCC]

4987 NM_000218.2(KCNQl):c.l515- 3784 KCNQ1 ['CAATCTCCTCTCCTCTCTCCACTGCRGGCT 2A>G GCGGGAACACCATCGGGCCAC]

4988 NM_000218.2(KCNQl):c.l787A> 3784 KCNQ1 ['ATCGGCGCCCGCCTGAACCGAGTAGRAGA G (p.Glu596Gly) C A AGGT AGGCTC AC GC GCC GGC ']

4989 NM_000138.4(FBNl):c.7916A>G 2200 FBN1 ['TGCATGTGTCCCGCCGGCTTCCAGTRTGAA (p.Tyr2639Cys) CAGTTCAGTGGAGGATGCCAA']

4990 NM_000138.4(FBNl):c.4337- 2200 FBN1 ['TTTTGCTTTTTTCTCCCTCCCCCCARGATAT 2A>G TGATGAGTGCTCCCTTCCGA']

4991 NM_000138.4(FBNl):c.3344A>G 2200 FBN1 ['GGTCATTTCCATTTTGCAGATATTGRTGAG (p.Aspl l l5Gly) TGTCAGAGAGATCCTCTCCTA]

4992 NM_001943.3(DSG2):c.880A>G 1829 DSG2 ['AGTCAACGTAGAAGTTACGCGCATARAAG (p.Lys294Glu) TGTTCGATGCAGATGAAATAGG]

4993 NM_001927.3 (DES) :c .1324 A>G 1674 DES ['TGAGCAAAGGGGTTCTGAGGTCCATRCCA (p.Thr442Ala) AGAAGACGGTGATGATCAAGAC]

4994 NM_004572.3(PKP2):c.l l71-2A>G 5318 PKP2 ['AGAAATATGCATCTGCTTCTTCCCCRGGTT

AACCAGCTTCGTGGCATCCTC]

4995 NM_001256850.1(TTN):c.45629- -1 ['GATATGAATATTTCACTCTTTTCTCRGGTC 2A>G CTCCCTCACCACCCCTTGACC]

4996 NM_013254.3(TBKl):c.l201A>G 29110 TBK1 ['ACTTCATATTTCAGTTTCCCTCCCTRAAGT (p.Lys401Glu) ACATCCACGTTATGATTTAGA]

4997 NM_030973.3(MED25):c.l l6A>G 81857 MED25 ['TACTTCGAGGGGCTCCGCAAGCACTRCCTG (p.Tyr39Cys) CTCCCGGCCATCGAGTGAGTG]

4998 NM_145207.2(SPATA5):c.l883A> 16637 SPATA5 ['TCTATTTTTCAGGTATCCTGGTCAGRTATA G (p.Asp628Gly) 8 GGAGGACTGGAAAGTATCAAA']

4999 NM_000016.5 ( AC ADM) :c .329 A> 34 ACADM ['ACTTTTGATGCTTGTTTAATTAGTGRAGAA G (p.Glul lOGly) TTGGCTTATGGATGTACAGGG]

5000 NM_000016.5(ACADM):c.797A> 34 ACADM ['CCTAAAGAAAATGTTTTAATTGGTGRCGG G (p.Asp266Gly) AGCTGGTTTCAAAGTTGCAATG]

5001 NM_000532.4(PCCB):c.655-2A>G 5096 PCCB ['GACTGTTCTGGAAATCTTTTATTTCRGGAC

ACCTCCTACCTGTTCATCACT']

5002 M_004453.3(ETFDH):c.929A>G 2110 ETFDH ['CATACCTATGGAGGATCTTTCCTCTRTCAT (p.Tyr310Cys) TTGAATGAAGGTGAACCCCTA]

5003 NM_000255.3(MUT):c.l885A>G 4594 MUT ['AAAAATGGGACAAGATGGCCATGACRGAG (p.Arg629Gly) GAGCAAAAGTTATTGCTACAGG]

5004 NM_000255.3(MUT):c.329A>G 4594 MUT ['TTTAGGCCCTGGACCATCCGCCAGTRTGCT (p.Tyrl lOCys) GGTTTTAGTACTGTGGAAGAA']

5005 NM_000017.3 ( AC AD S) : c.1108 A> 35 ACADS ['TCAGGCCATCCAGATCCTGGGCGGCRTGG G (p.Met370Val) GCTACGTGACAGAGATGCCGGC] 5006 NM_174917.4(ACSF3):c.lA>G 19732 ACSF3 ['TCCAGCTCGGCCGCCTGTCAGTGCARTGCT (p.MetlVal) 2 GCCCCATGTGGTGCTCACCTT']

5007 NM_000531.5(OTC):c.919A>G 5009 OTC ['GACATTTTTACACTGCTTGCCCAGARAGCC (p.Lys307Glu) AGAAGAAGTGGATGATGAAGT']

5008 NM_000030.2(AGXT):c.248A>G 189 AGXT ['ACACTGGTCATCTCTGGCTCGGGACRCTGT (p.His83Arg) GCCCTGGAGGCCGCCCTGGTC]

5009 NM_000030.2(AGXT):c.424-2A>G 189 AGXT ['CACCCACAGCCGTCCCTGCTTCCTCRGGGC (p.Gly_142Glnl45del) CTGGCCCAGCACAAGCCAGTG]

5010 NM_000030.2(AGXT):c.596-2A>G 189 AGXT ['CGTCCCGAGCAAACCACCCATCTACRGGC

ATCGACATCCTGTACTCGGGCT']

5011 NM_000030.2(AGXT):c.777-2A>G 189 AGXT ['TGGACCAAGCCCCCTCGTGTCTTCCRGGTA

CCATCACACAATCCCCGTCAT']

5012 NM_012203.1(GRHPR):c.84-2A>G 9380 GRHPR ['CTCCTGAGGGCCTCCCTTTCCCCGCRGCTG

TGAGGTGGAGCAGTGGGACTC]

5013 NM_012203.1(GRHPR):c.934A>G 9380 GRHPR ['CACCATGTCCTTGTTGGCAGCTAACRACTT (p.Asn312Asp) GCTGGCTGGCCTGAGAGGGGA']

5014 NM_203290.2(POLRlC):c.221A> 9533 POLR1C ['GTGGGAATTGACGCAGCCATTGCCARTGC G (p.Asn74Ser) TTTTCGACGAATTCTGCTAGCT']

5015 NM_006516.2(SLC2Al):c.848A>G 6513 SLC2A1 ['GCTGTGGTGCTGCAGCTGTCCCAGCRGCTG (p.Gln283Arg) TCTGGCATCAACGCTGTGAGT']

5016 NM_006516.2(SLC2Al):c.l9- 6513 SLC2A1 ['ATAACAGTGTGGTTTGTTTCTCCGCRGAAG 2A>G CTGACGGGTCGCCTCATGCTG]

5017 NM_021007.2(SCN2A):c.387- 6326 SCN2A ['ACTTTGTCTTCCTTGACGATATTCTRCTTTA 2A>G TTCAATATGCTCATTATGTG]

5018 NM_021007.2(SCN2A):c.851A>G 6326 SCN2A ['AATAAATGTTTGCAATGGCCTCCAGRTAAT (p.Asp284Gly) TCTTCCTTTGAAATAAATATC]

5019 NM_021007.2(SCN2A):c.4036A>G 6326 SCN2A ['CATGAATGTACTTCTGGTTTGTCTGRTCTTT (p.Ilel346Val) TGGCTAATATTCAGTATCAT']

5020 NM_001165963.1(SCNlA):c.4476 -1 ['TAATTTCAACCAGCAGAAAAAGAAGDTAA

+1A>G GTATTTCTAATATTTTCTCTCC]

5021 NM_001165963.1(SCNlA):c.l277 6323 SCN1A ['ATCCTGGCTGTGGTGGCCATGGCCTRCGAG A>G (p.Tyr426Cys) GAACAGAATCAGGCCACCTTG]

5022 NM_000391.3(TPPl):c.833A>G 1200 TPP1 ['GGGATTGAGGCCAGTCTAGATGTGCRGTA (p.Gln278Arg) CCTGATGAGTGCTGGTGCCAAC]

5023 NM_017882.2(CLN6):c.767A>G 54982 CLN6 ['GGAGAAGAGGAAGAGGCCGTTGCTGYCCA (p.Asp256Gly) GGAAGAGGCGCTTGCGCTTCTG]

5024 NM_002693.2(POLG):c.3470A>G 5428 POLG ['GGGCCCCGCATACCTGGTCAAGAGGYTGG (p.Asnl l57Ser) TGATCTGCAAGGCCAGGGCAGC]

5025 NM_002693.2(POLG):c.2840A>G 5428 POLG ['GTGGGCATCAGCCGTGAGCATGCCARAAT (p.Lys947Arg) CTTCAACTACGGCCGCATCTAT']

5026 NM_002693.2(POLG):c.2636A>G 5428 POLG ['CACAAGGGTGTAGCCAGGTGGGGCCYGCA (p.Gln879Arg) CCATGGCTTTCAACTCACTGCC]

5027 NM_000833.4(GRIN2A):c.2449A> 2903 GRIN2A ['GAGCAGCCAGCTGGACATTGACAACRTGG G (p.Met817Val) CGGGCGTATTCTACATGCTGGC] 5028 NM_000833.4(GRIN2A):c.l930A> 2903 GRIN2A ['CTTCTTCGCTGTCATATTCCTGGCTRGCTA G (p.Ser644Gly) CACAGCCAATCTGGCTGCCTT']

5029 NM_000156.5 (GAMT) : c .1 A>G 2593 GAMT ['GTCGGGTCGCCGTCCAGCCTGCAGCRTGA (p.MetlVal) GCGCCCCCAGCGCGACCCCCAT']

5030 NM_172107.2(KCNQ2):c.848A>G 3785 KCNQ2 ['CTGACCACCATTGGCTACGGGGACARGTA (p.Lys283Arg) CCCCCAGACCTGGAACGGCAGG]

5031 NM_172107.2(KCNQ2):c.611A>G 3785 KCNQ2 ['GCGCTCCGGAGCCTGCGCTTCCTGCRGATT (p.Gln204Arg) CTGCGGATGATCCGCATGGAC]

5032 NM_172107.2(KCNQ2):c.297- 3785 KCNQ2 ['CTGAGAGCGCGCGTTCCCTGCCCCCRGGTT 2A>G CCTCCTGGTTTTCTCCTGCCT']

5033 NM_001105243.1(PCDH19):c.l019 57526 PCDH19 ['GTCACCGTCAGCGTGCTGGACACCARTGA A>G (p.Asn340Ser) CAATCCGCCGGTCATCAACCTG]

5034 NM_001105243.1(PCDH19):c.695 57526 PCDH19 ['CTTAGTATCAAGGTGACCGACTCCADTGA A>G (p.Asn232Ser) CAACAACCCGGTGTTTAGCGAG]

5035 NM_052859.3(RFTl):c.454A>G 91869 RFT1 ['TTC AC AGC AGAAGGTGC ACTGACCTB GAG (p.Lysl52Glu) CTTCACAAACATATGTGCTTGT']

5036 NM_052859.3(RFTl):c. l222A>G 91869 RFT1 ['TCTCCTCCCCAGGTACAATTTTGTGRTGCT (p.Met408Val) GGCCCTGTCCTCCTCATTCCT']

5037 NM_020533.2(MCOLNl):c.l406A 57192 MCOLN1 ['TCTGAGTGCCTGTTCTCGCTCATCARTGGG >G (p.Asn469Ser) GACGACATGTTTGTGACGTTC]

5038 M_004456.4(EZH2):c.458A>G 2146 EZH2 ['TTCATTGAAGAACTAATAAAAAATTRTGAT (p.Tyrl53Cys) GGGAAAGTACACGGGGATAGA']

5039 NM_005045.3(RELN):c.2168A>G 5649 RELN ['ACCACGGATAGAGTAAAAGTTATGGYAAG (p.Tyr723Cys) AGGAGAGCCTGGAACTGCCAAA']

5040 NM_006772.2(SYNGAPl):c.388- 8831 SYNGAP1 ['CCCACCCCATCCCCATTTCCCCCCCRGCAA

2A>G GGCTTCCTGAGCCGACGGCTA']

5041 NM_001080508.2(TBX18):c.487A 9096 TBX18 ['GATAGGCACTGAGATGATCATCACCRAGG >G (p.Lysl63Glu) CCGGCAGGTAATGGGCAAGCTG]

5042 M_004964.2(HDACl):c.461A>G 3065 HDAC1 ['GAGGCATCTGGCTTCTGTTACGTCARTGAT (p.Asnl54Ser) ATCGTCTTGGCCATCCTGGAA']

5043 M_014946.3(SPAST):c.l l68A>G 6683 SPAST ['TGGTCCACCTGGGAATGGGAAGACARTGC (p.Met390Val) TGGTAAGGGTTCTCTTCAAATT']

5044 NM_000314.6(PTEN):c.71A>G 5728 PTEN ['TATCAAGAGGATGGATTCGACTTAGRCTTG (p.Asp24Gly) ACCTGTATCCATTTCTGCGGC]

5045 NM_004380.2(CREBBP):c.4409A> 1387 CREBBP ['GGGTCCTGCAGGTATGTGACAGGGCRCAT G (p.Hisl470Arg) CTGGGCCTGTCCTCCAAGTGAA']

5046 NM_018206.4(VPS35):c. l463A>G 55737 VPS35 ['GATCCAGAAGATTTTGCTGATGAGCRGAG (p.Gln488Arg) CCTTGTGGGCCGCTTCATTCAT']

5047 NM_152296.4(ATPlA3):c.971A>G 478 ATP 1 A3 ['GGCATCATCGTGGCCAATGTCCCAGRGGG (p.Glu324Gly) TCTGCTGGCCACTGTCACTGTA']

5048 NM_172107.2(KCNQ2):c.710A>G 3785 KCNQ2 ['TCTCAGGAGCTGGTCACTGCCTGGTRCATC (p.Tyr237Cys) GGCTTCCTTTGTCTCATCCTG]

5049 NM_001017980.3(VMA21):c. l63+ 20354 VMA21 ['ACTAAATCTTACATATTTGAAGGTARTCTT 4A>G 7 AGACCCATTAAAACAAGATGT'] 5050 NM_000489.4(ATRX):c.740A>G 546 ATRX [TTCTGCAAGAAATGCATTCTACGCARCCTT (p.Asn247Ser) GGTCGAAAGGAGTTGTCCACA]

5051 NM_021147.4(CCNO):c.716A>G 10309 CCNO ['CCCACCATTAGCTTCTTCCTGGAGCRTTTC (p.His239Arg) ACGCACGCTCGCGTGGAGGCG]

5052 NM_031924.4(RSPH3):c.631- 83861 RSPH3 ['CTCTAGAGAATCAGGCCGTCCGAGCYAAC 2A>G AGTGATAGAAAATACTTCTAGA]

5053 NM_000069.2(CACNAlS):c.3526- 779 CACNA1S ['TCGCTTTCCCATCCTTTTCCTTCCCRGGGCT 2A>G ACTTTGGAGACCCCTGGAAT']

5054 NM_000533.4(PLPl):c. lA>G 5354 PLP1 ['CAATTGGAGTCAGAGTCCCAAAGACRTGG (p.MetlVal) GTAAGTTTCAAAAACTTTAGCA']

5055 NM_207352.3(CYP4V2):c.l396A> 28544 CYP4V2 ['CGTGCCCTTCTCTGCTGGCCCCAGGRACTG G (p.Asn466Asp) 0 TATAGGTTTGTATCCATCTGA']

5056 NM_033409.3(SLC52A3):c.403A> 11327 SLC52A3 ['ACAAAGAAGGTGGTGAGGTAGTAGGYGG G (p.Thrl35Ala) 8 GCAGCCGGCTCATGAACGGCAGG]

5057 NM_033409.3(SLC52A3):c.62A>G 11327 SLC52A3 ['CAGGGGCAGCTCTACCCAGAGCCCAYTGA (p.Asn21Ser) 8 TGGTCACCCAGGAGCCCATTCC]

5058 NM_017662.4(TRPM6):c.3173A> 14080 TRPM6 ['CAAGCTGTCTACCTCTTCGTGCAATRTATC G (p.Tyrl058Cys) 3 ATCATGGTGAACCTGTTGATT']

5059 NM_006642.3(SDCCAG8):c.221- 10806 SDCCAG8 ['AATAAACCCTCTGCTTTTGCTCTATRGTTA 2A>G ATCAGCTCAAAGATTTGTTGC]

5060 NM_022455.4(NSDl):c.5990A>G 64324 NSD1 ['CAAGAACATGATATCACTAATTTCTRTATG (p.Tyrl997Cys) CTCACCCTAGACAAAGTAAGT']

5061 NM_000352.4(ABCC8):c.563A>G 6833 ABCC8 ['GGGATGCTGCTCCTCGTGGAGGTCARTGTC (p.Asnl88Ser) ATCAGGGTGAGGGTAAGCAGG]

5062 NM_000275.2(OCA2):c.l427A>G 4948 OCA2 ['GATGGCAGTGGCAGCTCCTCCAATGYTTGT (p.Asn476Ser) GAAGATCACTTCTGCAATCAG]

5063 NM_001848.2(COL6Al):c. l003- 1291 COL6A1 ['ATTTTCTAGTTTTCTTCCTCTTTCCRGGGGG 2A>G AGATGGGGTACCCAGGCCTG]

5064 NM_003560.2(PLA2G6):c.l349- 8398 PLA2G6 ['CAGCATGCCCTGCTCTGTGCCTCACRGAAC 2A>G TACAGGATCTCATGCACATCT']

5065 NM_178151.2(DCX):c.280A>G 1641 DCX ['TGACCTGACGCGATCTCTGTCTGACRACAT (p.Asn94Asp) CAACCTGCCTCAGGGAGTGCG]

5066 NM_000425.4(LlCAM):c.2351A> 3897 L1CAM ['TCCAACACGTCCACCTTCGTGCCCTRTGAG G (p.Tyr784Cys) ATCAAAGTCCAGGCCGTCAAC]

5067 NM_000052.6(ATP7A):c.2173- 538 ATP7A ['TCAATGATTATCATTCCTATATTGCRGTTTT 2A>G TCGGAGGCTGGTACTTCTAC]

5068 NM_020247.4(ADCK3):c.l286A> 56997 ADCK3 ['CTGCTGAAGGGCCACCCCTTCTTCTRTGTG G (p.Tyr429Cys) CCTGAGATTGTGGATGAGCTC]

5069 NM_000143.3(FH):c.554A>G 2271 FH ['AAACAGCAAAGCTCACATACTGACCYGGC (p.Glnl85Arg) TTTTATTAACATGATCGTTGGG]

5070 NM_033109.4(PNPTl):c. l453A>G 87178 PNPT1 ['AAACTTCCGCCACATGCAGATGCCAKAGA (p.Met485Val) AGATGACCCTATAGAAAGAAAA']

5071 NM_005888.3(SLC25A3):c.l58- 5250 SLC25A3 ['TACTTACTTGATTTTTTTTTTTCCARTCAAA 9A>G CAGAGCAGTATAGCTGTGAC] 5072 NM_181426.1(CCDC39):c.610- 33982 CCDC39 ['TTGTGCTGCTTTATCCAATTCTAACYGTCA 2A>G 9 AACAGAGAGCAAAGAACATTT']

5073 NM_153704.5(TMEM67):c.725A> 91147 TMEM67 ['ATTGTTCTGTTGTAGGTATATGCCARTCTA G (p.Asn242Ser) ACATCTTGTCAAGCTCTTGGA']

5074 NM_000166.5(GJBl):c.305A>G 2705 GJB1 ['CACGTGGCTCACCAGCAACACATAGRGAA (p.Glul02Gly) GAAAATGCTACGGCTTGAGGGC]

5075 NM_019098.4(CNGB3):c.l l93A> 54714 CNGB3 ['AATTAAAGTTCGAACTGCCCAATAAYAAC G (p.Tyr398Cys) ATCTCAGATACCTGTGAAAACA']

5076 NM_000070.2(CAPN3):c.l l94- 825 CAPN3 ['CCATATGGCTCTCTCTCTTCTTCCARCCTCT 9A>G CAGGATGTCCTATGAGGATT']

5077 NM_002860.3(ALDH18Al):c2345 5832 ALDH18A [' AGGAAT AGGGAGGTTCTC ATGAAGAB ATT A>G (p.Tyr782Cys) 1 TTAAACTTCCATGCTCTGAGAA]

5078 M_001414.3(EIF2Bl):c.824A>G 1967 EIF2B1 ['CAGAGTGATTAAGGAAGGGGCAGTGYAGT (p.Tyr275Cys) CGACCCACGGATGCTCCTCTTT']

5079 NM_182896.2(ARL13B):c.461A>G 20089 ARL13B ['TGTCTATCTCTGGAAAAATTGGTCARTGAG (p.Asnl54Ser) 4 CACAAGTGCCTGTGTCAGATA']

5080 NM_001134831.1(AHIl):c. l l52- 54806 AHI1 ['TAGTAAGATGAAACAGGCCGTCCACYGTA 2A>G CAAAAAAAGATACTTCCATTAA']

5081 NM_153704.5(TMEM67):c.978+3 91147 TMEM67 ['TCAGTTTTAAAGGAGAAAACCAGGTRAAA A>G GTGTCTAATATCATTAGAGGAT']

5082 NM_015681.3(B9Dl):c.95A>G 27077 B9D1 ['CCAGTCCTGGCCGTACACAAAGCAGYACT (p.Tyr32Cys) TGCAGTAGAGGTCATCATACTC]

5083 M_014049.4(ACAD9):c. lA>G 28976 ACAD 9 ['CTGAGGCTGGGGAACATCGGGCAGCWTGA (p.MetlVal) GCGGCTGCGGGCTCTTCCTGCG]

Table 8. xCas9v3 Mutations (K294R/Q1256K Series)

Q1256K Q1256K Q1256K Q1256K Q1256K

Table 9. xCas9v3 Mutations (A262T/S409I Series)

Table 10. PAM Depletion Scores (xCas9v3.0-3.6 Mutations)

ATC 0.52 0.50 0.45 0.45 0.47 0.42 0.38

ATG 11.38 14.85 23.55 40.11 20.48 30.27 108.77

ATT 0.48 0.46 0.43 0.42 0.43 0.41 0.39

CAA 1.55 2.00 6.63 5.06 3.42 6.29 4.66

CAC 0.57 0.65 0.99 0.75 0.86 0.93 3.20

CAG 15.05 11.83 26.90 26.86 22.15 32.07 137.31

CAT 4.41 6.06 17.67 7.55 6.30 8.13 7.87

CCA 0.48 0.46 0.41 0.43 0.42 0.40 0.39

CCC 0.53 0.51 0.46 0.45 0.45 0.43 0.44

CCG 3.35 2.67 6.87 6.98 4.69 8.56 5.44

CCT 0.53 0.50 0.45 0.49 0.46 0.43 0.38

CGA 9.23 49.45 43.50 106.20 62.04 27.17 116.32

CGC 13.79 8.59 17.62 15.06 12.16 21.40 11.61

CGG 16.85 223.84 46.41 346.14 96.28 90.82 252.73

CGT 12.66 23.87 36.06 42.02 20.18 27.33 179.69

CTA 0.54 0.50 0.45 0.47 0.47 0.45 0.49

CTC 0.51 0.48 0.43 0.44 0.45 0.42 0.38

CTG 5.39 3.40 6.92 8.28 5.95 11.34 4.20

CTT 0.52 0.52 0.46 0.46 0.44 0.44 0.82

GAA 10.98 7.67 14.45 11.25 9.75 11.86 6.86

GAC 0.88 1.35 4.85 2.92 2.40 5.25 4.15

GAG 11.85 55.33 39.91 118.83 109.84 85.83 390.44

GAT 7.69 5.68 10.55 9.22 6.41 11.03 9.53

GCA 0.49 0.49 0.47 0.52 0.53 0.59 0.61

GCC 0.53 0.52 0.50 0.50 0.49 0.46 0.52

GCG 13.68 13.44 22.56 46.72 32.75 35.86 97.69

GCT 0.51 0.50 0.45 0.48 0.46 0.45 0.61

GGA 9.74 82.32 39.45 172.39 102.30 85.53 77.46

GGC 12.21 10.04 17.84 15.18 14.04 27.07 17.46

GGG 18.90 381.76 70.36 281.12 164.21 111.87 718.40

GGT 10.87 22.11 32.25 88.31 40.66 40.16 257.92

GTA 0.56 0.59 0.77 0.72 0.76 1.03 1.55

GTC 0.52 0.51 0.46 0.52 0.49 0.45 0.58

GTG 11.43 16.42 28.54 72.25 33.31 47.65 382.48

GTT 0.48 0.45 0.41 0.43 0.43 0.42 0.76

TAA 0.58 0.67 1.59 0.99 1.04 1.69 1.53

TAC 0.56 0.54 0.51 0.51 0.52 0.50 0.44

TAG 11.34 10.19 15.99 22.04 15.24 27.89 35.59

TAT 0.56 0.64 1.26 0.85 0.89 1.21 2.60 TCA 0.50 0.48 0.43 0.45 0.46 0.45 0.44

TCC 0.50 0.48 0.43 0.46 0.44 0.42 0.47

TCG 10.38 8.24 14.95 15.64 9.96 15.57 34.80

TCT 0.52 0.50 0.45 0.44 0.46 0.41 0.46

TGA 9.68 61.64 44.45 188.12 99.42 46.89 186.41

TGC 13.64 9.07 15.11 11.69 11.22 15.01 8.15

TGG 12.90 223.88 63.67 259.65 115.56 80.51 210.65

TGT 11.53 18.90 31.99 36.30 18.72 21.90 122.87

TTA 0.61 0.57 0.52 0.54 0.51 0.52 0.30

TTC 0.53 0.50 0.44 0.45 0.44 0.43 0.27

TTG 13.57 6.61 10.15 13.27 7.38 14.26 12.24

TTT 0.53 0.49 0.44 0.45 0.48 0.44 0.28

Table 10 Continued. PAM Depletion Scores (xCas9v3.7-3.12 Mutations)

CCG 4.35 5.28 5.57 1.37 0.94 0.83

CCT 0.40 1.04 0.36 1.22 0.67 0.59

CGA 4.47 7.60 5.26 1.35 1.36 2.02

CGC 13.35 10.98 5.45 4.03 5.37 3.66

CGG 6.06 5.52 25.23 31.85 19.44 34.65

CGT 17.13 7.41 17.31 0.63 1.44 0.66

CTA 0.76 0.50 0.50 1.97 1.45 1.05

CTC 0.40 0.26 0.65 0.58 0.45 0.81

CTG 5.64 9.49 6.82 1.35 1.41 2.11

CTT 0.50 0.63 0.68 0.54 0.73 0.88

GAA 9.81 6.07 4.68 2.07 0.87 1.09

GAC 3.91 3.95 2.82 0.44 0.86 0.56

GAG 23.26 21.32 9.88 16.93 18.42 40.73

GAT 5.06 9.85 1.07 0.75 1.06 0.63

GCA 0.56 0.81 0.79 1.46 0.44 0.89

GCC 0.35 0.52 0.71 0.65 3.67 0.73

GCG 16.11 12.53 9.43 1.59 1.98 2.22

GCT 0.42 0.88 0.27 0.66 1.14 0.76

GGA 3.01 18.40 33.07 27.28 16.20 46.82

GGC 6.03 3.83 11.69 8.03 22.56 3.92

GGG 12.16 10.26 15.08 17.30 25.85 128.03

GGT 11.25 13.77 2.94 12.71 16.11 16.22

GTA 1.38 1.08 1.24 0.75 3.52 1.09

GTC 0.96 0.31 0.50 0.93 0.72 0.81

GTG 6.68 17.93 26.86 9.93 9.61 2.72

GTT 0.45 0.33 0.99 0.65 1.61 1.01

TAA 3.04 2.16 1.84 1.21 1.08 0.68

TAC 0.61 0.52 0.68 0.95 0.68 0.86

TAG 4.76 15.71 1.10 8.15 8.25 8.87

TAT 1.62 2.10 1.01 0.73 0.74 0.66

TCA 0.41 0.66 0.58 0.46 0.77 0.68

TCC 0.54 0.29 0.38 1.36 0.86 0.82

TCG 1.41 4.20 9.11 0.84 0.46 0.69

TCT 0.47 0.44 0.38 0.60 1.00 0.94

TGA 22.42 5.39 15.72 1.78 3.13 3.69

TGC 6.78 6.81 11.35 2.41 6.55 4.08

TGG 20.36 11.36 11.56 9.97 21.64 19.87

TGT 10.32 8.82 21.17 0.94 0.79 0.73

TTA 0.65 0.29 0.77 0.94 1.35 0.75 TTC 0.62 1.07 0.55 0.86 1.07 0.58

TTG 8.41 6.07 9.07 0.67 0.56 0.72

TTT 0.43 0.56 0.44 0.68 0.60 0.75

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[00275] All publications, patents, patent applications, publication, and database entries {e.g., sequence database entries) mentioned herein, e.g., in the Background, Summary, Detailed Description, Examples, and/or References sections, are hereby incorporated by reference in their entirety as if each individual publication, patent, patent application, publication, and database entry was specifically and individually incorporated herein by reference. In case of conflict, the present application, including any definitions herein, will control.

EQUIVALENTS AND SCOPE

[00276] Those skilled in the art will recognize, or be able to ascertain using no more than routine experimentation, many equivalents of the embodiments described herein. The scope of the present disclosure is not intended to be limited to the above description, but rather is as set forth in the appended claims.

[00277] Articles such as "a," "an," and "the" may mean one or more than one unless indicated to the contrary or otherwise evident from the context. Claims or descriptions that include "or" between two or more members of a group are considered satisfied if one, more than one, or all of the group members are present, unless indicated to the contrary or otherwise evident from the context. The disclosure of a group that includes "or" between two or more group members provides embodiments in which exactly one member of the group is present, embodiments in which more than one members of the group are present, and embodiments in which all of the group members are present. For purposes of brevity those embodiments have not been individually spelled out herein, but it will be understood that each of these embodiments is provided herein and may be specifically claimed or disclaimed.

[00278] It is to be understood that the invention encompasses all variations, combinations, and permutations in which one or more limitation, element, clause, or descriptive term, from one or more of the claims or from one or more relevant portion of the description, is introduced into another claim. For example, a claim that is dependent on another claim can be modified to include one or more of the limitations found in any other claim that is dependent on the same base claim. Furthermore, where the claims recite a composition, it is to be understood that methods of making or using the composition according to any of the methods of making or using disclosed herein or according to methods known in the art, if any, are included, unless otherwise indicated or unless it would be evident to one of ordinary skill in the art that a contradiction or inconsistency would arise.

[00279] Where elements are presented as lists, e.g., in Markush group format, it is to be understood that every possible subgroup of the elements is also disclosed, and that any element or subgroup of elements can be removed from the group. It is also noted that the term "comprising" is intended to be open and permits the inclusion of additional elements or steps. It should be understood that, in general, where an embodiment, product, or method is referred to as comprising particular elements, features, or steps, embodiments, products, or methods that consist, or consist essentially of, such elements, features, or steps, are provided as well. For purposes of brevity those embodiments have not been individually spelled out herein, but it will be understood that each of these embodiments is provided herein and may be specifically claimed or disclaimed.

[00280] Where ranges are given, endpoints are included. Furthermore, it is to be understood that unless otherwise indicated or otherwise evident from the context and/or the understanding of one of ordinary skill in the art, values that are expressed as ranges can assume any specific value within the stated ranges in some embodiments, to the tenth of the unit of the lower limit of the range, unless the context clearly dictates otherwise. For purposes of brevity, the values in each range have not been individually spelled out herein, but it will be understood that each of these values is provided herein and may be specifically claimed or disclaimed. It is also to be understood that unless otherwise indicated or otherwise evident from the context and/or the understanding of one of ordinary skill in the art, values expressed as ranges can assume any subrange within the given range, wherein the endpoints of the subrange are expressed to the same degree of accuracy as the tenth of the unit of the lower limit of the range.

[00281] In addition, it is to be understood that any particular embodiment of the present invention may be explicitly excluded from any one or more of the claims. Where ranges are given, any value within the range may explicitly be excluded from any one or more of the claims. Any embodiment, element, feature, application, or aspect of the compositions and/or methods of the invention, can be excluded from any one or more claims. For purposes of brevity, all of the embodiments in which one or more elements, features, purposes, or aspects is excluded are not set forth explicitly herein.

Claims

What is claimed is:

1. A recombinant Cas9 protein comprising an amino acid sequence that is at least 80%, identical to the amino acid sequence of a Cas9 as provided by any one of SEQ ID NOs: 9- 262,

wherein the amino acid sequence of the Cas9 protein comprises at least one, at least two, at least three, at least four, at least five, at least six, or at least seven mutations in an amino acid residue selected from the group consisting of amino acid residues 262, 267, 294, 405, 409, 480, 543, 694, 1219, 1224, 1256, and 1362 of the amino acid sequence provided in SEQ ID NO: 9, or in a corresponding amino acid residue in any of the amino acid sequences provided in SEQ ID NOs: 10-262, and

wherein the amino acid sequence of the recombinant Cas9 protein is not identical to the amino acid sequence of a naturally occurring Cas9 protein.

2. The Cas9 protein of claim 1 comprising an amino acid sequence that is at least 85%, at least 90%, at least 92%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or at least 99.5% identical to the amino acid sequence of a Cas9 as provided by any one of SEQ ID NOs: 9-262.

3. The Cas9 protein of claim 1, wherein the Cas9 protein comprises a RuvC and an HNH domain.

4. The Cas9 protein of claim 1, wherein the amino acid sequence of the Cas9 protein comprises at least one, at least two, at least three, at least four, at least five, at least six, or at least seven mutations selected from the group consisting of X262T, X267G, X294R, X405I, X409I, X480K, X543D, X694I, X1219V, X1224K, X1256K, and X1362P of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262, wherein X represents any amino acid.

5. The Cas9 protein of claim 1, wherein the amino acid sequence of the Cas9 protein comprises at least one, at least two, at least three, at least four, at least five, at least six, or at least seven mutations selected from the group consisting of A262T, S267G, K294R, F405I, S409I, E480K, E543D, M694I, E1219V, N1224K, Q1256K, and L1362P of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262.

6. The Cas9 protein of claim 1, wherein the amino acid sequence of the Cas9 protein comprises an X1219V mutation of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10- 262, wherein X represents any amino acid.

7. The Cas9 protein of claim 1, wherein the amino acid sequence of the Cas9 protein comprises an E1219V mutation of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10- 262.

8. The Cas9 protein of claim 1, wherein the amino acid sequence of the Cas9 protein comprises an X294R mutation of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10- 262, wherein X represents any amino acid.

9. The Cas9 protein of claim 1, wherein the amino acid sequence of the Cas9 protein comprises an K294R mutation of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10- 262.

10. The Cas9 protein of claim 1, wherein the amino acid sequence of the Cas9 protein comprises an X1256K mutation of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10- 262, wherein X represents any amino acid.

11. The Cas9 protein of claim 1, wherein the amino acid sequence of the Cas9 protein comprises an Q1256K mutation of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10- 262.

12. The Cas9 protein of claim 1, wherein the amino acid sequence of the Cas9 protein comprises an X694I mutation of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10- 262, wherein X represents any amino acid.

13. The Cas9 protein of claim 1, wherein the amino acid sequence of the Cas9 protein comprises an M694I mutation of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10- 262.

14. The Cas9 protein of claim 1, wherein the amino acid sequence of the Cas9 protein comprises an X543D mutation of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10- 262, wherein X represents any amino acid.

15. The Cas9 protein of claim 1, wherein the amino acid sequence of the Cas9 protein comprises an E543D mutation of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10- 262.

16. The Cas9 protein of claim 1, wherein the amino acid sequence of the Cas9 protein comprises an X480K mutation of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10- 262, wherein X represents any amino acid.

17. The Cas9 protein of claim 1, wherein the amino acid sequence of the Cas9 protein comprises an E480K mutation of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10- 262.

18. The Cas9 protein of claim 1, wherein the amino acid sequence of the Cas9 protein comprises an X409I mutation of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10- 262, wherein X represents any amino acid.

19. The Cas9 protein of claim 1, wherein the amino acid sequence of the Cas9 protein comprises an S409I mutation of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10- 262.

20. The Cas9 protein of claim 1, wherein the amino acid sequence of the Cas9 protein comprises an X262T mutation of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10- 262, wherein X represents any amino acid.

21. The Cas9 protein of claim 1, wherein the amino acid sequence of the Cas9 protein comprises an A262T mutation of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10- 262.

22. A recombinant Cas9 protein comprising an amino acid sequence that is at least 80%, identical to the amino acid sequence of a Cas9 as provided by any one of SEQ ID NOs: 9- 262,

wherein the amino acid sequence of the Cas9 protein comprises at least one, at least two, at least three, at least four, at least five, at least six, or at least seven mutations in an amino acid residue selected from the group consisting of amino acid residues 262, 267, 294, 405, 409, 480, 543, 694, 1219, 1224, 1256, and 1362 of the amino acid sequence provided in SEQ ID NO: 9, or in a corresponding amino acid residue in any of the amino acid sequences provided in SEQ ID NOs: 10-262, and

wherein the amino acid sequence of the recombinant Cas9 protein is not identical to the amino acid sequence of a naturally occurring Cas9 protein.

23. The Cas9 protein of claim 22 comprising an amino acid sequence that is at least 85%, at least 90%, at least 92%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or at least 99.5% identical to the amino acid sequence of a Cas9 as provided by any one of SEQ ID NOs: 9-262.

24. The Cas9 protein of claim 22 or 23, wherein the Cas9 protein comprises a RuvC and an HNH domain.

25. The Cas9 protein of any one of claims 22-24, wherein the amino acid sequence of the Cas9 protein comprises at least one, at least two, at least three, at least four, at least five, at least six, or at least seven mutations selected from the group consisting of X262T, X267G, X294R, X405I, X409I, X480K, X543D, X694I, X1219V, X1224K, X1256K, and X1362P of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262, wherein X represents any amino acid.

26. The Cas9 protein of any one of claims 22-25, wherein the amino acid sequence of the Cas9 protein comprises at least one, at least two, at least three, at least four, at least five, at least six, or at least seven mutations selected from the group consisting of A262T, S267G, K294R, F405I, S409I, E480K, E543D, M694I, E1219V, N1224K, Q1256K, and L1362P of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262.

27. The Cas9 protein of any one of claims 22-26, wherein the amino acid sequence of the Cas9 protein comprises an X1219V mutation of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262, wherein X represents any amino acid.

28. The Cas9 protein of any one of claims 22-27, wherein the amino acid sequence of the Cas9 protein comprises an E1219V mutation of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262.

29. The Cas9 protein of any one of claims 22-28, wherein the amino acid sequence of the Cas9 protein comprises an X480K mutation of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262, wherein X represents any amino acid.

30. The Cas9 protein of any one of claims 22-29, wherein the amino acid sequence of the Cas9 protein comprises an E480K mutation of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262.

31. The Cas9 protein of any one of claims 22-30, wherein the amino acid sequence of the Cas9 protein comprises an X543D mutation of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262, wherein X represents any amino acid.

32. The Cas9 protein of any one of claims 22-31, wherein the amino acid sequence of the Cas9 protein comprises an E543D mutation of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262.

33. The Cas9 protein of any of claims 22-32, wherein the amino acid sequence of the Cas9 protein comprises the mutations X480K, X543D, and X1219V of the amino acid sequence provided in SEQ ID NO: 9, or corresponding mutations in any of the amino acid sequences provided in SEQ ID NOs: 10-262, wherein X represents any amino acid.

34. The Cas9 protein of any of claims 22-32, wherein the amino acid sequence of the Cas9 protein comprises the mutations X262T, X409I, X480K, X543D, X694I, and X1219V of the amino acid sequence provided in SEQ ID NO: 9, or corresponding mutations in any of the amino acid sequences provided in SEQ ID NOs: 10-262, wherein X represents any amino acid.

35. The Cas9 protein of any of claims 22-32, wherein the amino acid sequence of the Cas9 protein comprises the mutations X294R, X480K, X543D, X1219V, X1256K, and X1362P of the amino acid sequence provided in SEQ ID NO: 9, or corresponding mutations in any of the amino acid sequences provided in SEQ ID NOs: 10-262, wherein X represents any amino acid.

36. The Cas9 protein of any of claims 22-32, wherein the amino acid sequence of the Cas9 protein comprises the mutations X294R, X480K, X543D, X1219V, and X1256K of the amino acid sequence provided in SEQ ID NO: 9, or corresponding mutations in any of the amino acid sequences provided in SEQ ID NOs: 10-262, wherein X represents any amino acid.

37. The Cas9 protein of any of claims 22-32, wherein the amino acid sequence of the Cas9 protein comprises the mutations X267G, X294R, X480K, X543D, X1219V, X1224K, and X1256K of the amino acid sequence provided in SEQ ID NO: 9, or corresponding mutations in any of the amino acid sequences provided in SEQ ID NOs: 10-262, wherein X represents any amino acid.

38. The Cas9 protein of any of claims 22-32, wherein the amino acid sequence of the Cas9 protein comprises the mutations X262T, X405I, X409I, X480K, X543D, X694I, and X1219V of the amino acid sequence provided in SEQ ID NO: 9, or corresponding mutations in any of the amino acid sequences provided in SEQ ID NOs: 10-262, wherein X represents any amino acid.

39. The Cas9 protein of any of claims 22-32, wherein the amino acid sequence of the Cas9 protein comprises the mutations E480K, E543D, and E1219V of the amino acid sequence provided in SEQ ID NO: 9, or corresponding mutations in any of the amino acid sequences provided in SEQ ID NOs: 10-262.

40. The Cas9 protein of any of claims 22-32, wherein the amino acid sequence of the Cas9 protein comprises the mutations A262T, S409I, E480K, E543D, M694I, and E1219V of the amino acid sequence provided in SEQ ID NO: 9, or corresponding mutations in any of the amino acid sequences provided in SEQ ID NOs: 10-262.

41. The Cas9 protein of any of claims 22-32, wherein the amino acid sequence of the Cas9 protein comprises the mutations K294R, E480K, E543D, E1219V, Q1256K, and L1362P of the amino acid sequence provided in SEQ ID NO: 9, or corresponding mutations in any of the amino acid sequences provided in SEQ ID NOs: 10-262.

42. The Cas9 protein of any of claims 22-32, wherein the amino acid sequence of the Cas9 protein comprises the mutations K294R, E480K, E543D, E1219V, and Q1256K of the amino acid sequence provided in SEQ ID NO: 9, or corresponding mutations in any of the amino acid sequences provided in SEQ ID NOs: 10-262.

43. The Cas9 protein of any of claims 22-32, wherein the amino acid sequence of the Cas9 protein comprises the mutations S267G, K294R, E480K, E543DE1219V, N1224K, and Q1256K of the amino acid sequence provided in SEQ ID NO: 9, or corresponding mutations in any of the amino acid sequences provided in SEQ ID NOs: 10-262.

44. The Cas9 protein of any of claims 22-32, wherein the amino acid sequence of the Cas9 protein comprises the mutations A262T, F405I, S409I, E480K, E543D, M694I, and E1219V of the amino acid sequence provided in SEQ ID NO: 9, or corresponding mutations in any of the amino acid sequences provided in SEQ ID NOs: 10-262.

45. The Cas9 protein of any one of claims 24-44, wherein the amino acid sequence of the HNH domain is at least 80%, at least 85%, at least 90%, at least 92%, at least 95%, at least 96%), at least 97%, at least 98%>, at least 99%, or at least 99.5% identical to the amino acid sequence of the HNH domain of any of SEQ ID NOs: 9-262.

46. The Cas9 protein of any one of claims 24-45, wherein the amino acid sequence of the HNH domain is identical to the amino acid sequence of the HNH domain of SEQ ID NO: 9.

47. The Cas9 protein of any one of claims 24-46, wherein the amino acid sequence of the RuvC domain is at least 80%, at least 85%, at least 90%, at least 92%, at least 95%, at least 96%), at least 97%, at least 98%, at least 99%, or at least 99.5% identical to the amino acid sequence of the RuvC domain of any of SEQ ID NOs: 9-262.

48. The Cas9 protein of any one of claims 24-47, wherein the amino acid sequence of the RuvC domain is identical to the amino acid sequence of the RuvC domain of SEQ ID NO: 9.

49. The Cas9 protein of any one of claims 22-48, wherein the Cas9 protein comprises a DIOA and/or a H840A mutation of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10- 262.

50. The Cas9 protein of any one of claims 22-48, wherein the Cas9 protein comprises a DlOXi and/or a H840X₂ mutation of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10- 262, wherein X₁ is any amino acid except for D and wherein X₂ is any amino acid except for H.

51. The Cas9 protein of any one of claims 22-50, wherein the Cas9 protein comprises an D10A mutation of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262.

52. The Cas9 protein of claim 51, wherein the Cas9 protein comprises an H at amino acid residue 840 of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding residue in any of the amino acid sequences provided in SEQ ID NOs: 10-262.

53. The Cas9 protein of any one of claims 22-51, wherein the Cas9 protein comprises an H840A mutation of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262.

54. The Cas9 protein of claim 53, wherein the Cas9 protein comprises an D at amino acid residue 10 of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding residue in any of the amino acid sequences provided in SEQ ID NOs: 10-262.

55. The Cas9 protein of any one of claims 22-54, wherein the Cas9 protein exhibits an increased activity on a target sequence that does not comprise the canonical PAM (5 '-NOGS ') at its 3' end as compared to Streptococcus pyogenes Cas9 as provided by SEQ ID NO: 9.

56. A recombinant Cas9 protein comprising an amino acid sequence that is at least 90% identical to the amino acid sequence of Streptococcus pyogenes Cas9 as provided by SEQ ID NO: 9, or to a fragment thereof,

wherein the amino acid sequence of the Cas9 protein comprises at least one, at least two, at least three, at least four, at least five, at least six, or at least seven mutations in an amino acid residue selected from the group consisting of amino acid residues 262, 267, 294, 405, 409, 480, 543, 694, 1219, 1224, 1256, and 1362 of the amino acid sequence provided in SEQ ID NO: 9, wherein the amino acid sequence of the recombinant Cas9 protein is not identical to the amino acid sequence of a naturally occurring Cas9 protein, and

wherein the recombinant Cas9 protein exhibits an increased activity on a target sequence that does not comprise the canonical PAM (5'-NGG-3 ') at its 3' end as compared to Streptococcus pyogenes Cas9 as provided by SEQ ID NO: 9.

57. The Cas9 protein of claim 56, wherein the Cas9 protein comprises a RuvC and an HNH domain.

58. The Cas9 protein of claim 56 or 57, wherein the Cas9 protein exhibits an activity on a target sequence having a 3' end that is not directly adjacent to the canonical PAM sequence (5'-NGG-3 ') that is at least 5-fold, at least 10-fold, at least 50-fold, at least 100-fold, at least 500-fold, at least 1,000-fold, at least 5,000-fold, at least 10,000-fold, at least 50,000-fold, at least 100,000-fold, at least 500,000-fold, or at least 1,000,000-fold increased as compared to the activity of Streptococcus pyogenes Cas9 as provided by SEQ ID NO: 9 on the same target sequence.

59. The Cas9 protein of claim 58, wherein the 3' end of the target sequence is directly adjacent to an AGC, GAG, TTT, GTG, or CAA sequence.

60. The Cas9 protein of claim 58 or 59, wherein the 3' end of the target sequence is directly adjacent to a sequence selected from the group consisting of CAC, GAT, TAA, ACG, CGA, and CGT.

61. The Cas9 protein of any one of claims 56-60, wherein the Cas9 protein activity is measured by a nuclease assay, a deamination assay, or a transcriptional activation assay.

62. The Cas9 protein of claim 61, wherein the transcriptional activation assay is a GFP activation assay.

63. The Cas9 protein of any one of claims 56-62, wherein the amino acid sequence of the Cas9 protein comprises at least one, at least two, at least three, at least four, at least five, at least six, or at least seven mutations selected from the group consisting of X262T, X267G, X294R, X405I, X409I, X480K, X543D, X694I, X1219V, X1224K, X1256K, and X1362P of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262, wherein X represents any amino acid.

64. The Cas9 protein of any one of claims 56-63, wherein the amino acid sequence of the Cas9 protein or the fragment thereof comprises at least one, at least two, at least three, at least four, at least five, at least six, or at least seven mutations selected from the group consisting of A262T, S267G, K294R, F405I, S409I, E480K, E543D, M694I, E1219V, N1224K, Q1256K, and L1362P of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10- 262.

65. The Cas9 protein of any one of claims 56-64, wherein the amino acid sequence of the Cas9 protein or the fragment thereof comprises an X1219V mutation of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262, wherein X represents any amino acid.

66. The Cas9 protein of any one of claims 56-65, wherein the amino acid sequence of the Cas9 protein or the fragment thereof comprises an E1219V mutation of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262.

67. The Cas9 protein of any one of claims 56-66, wherein the amino acid sequence of the Cas9 protein or the fragment thereof comprises an X480k mutation of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262, wherein X represents any amino acid.

68. The Cas9 protein of any one of claims 56-67, wherein the amino acid sequence of the Cas9 protein or the fragment thereof comprises an E480K mutation of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262.

69. The Cas9 protein of any one of claims 56-68, wherein the amino acid sequence of the Cas9 protein or the fragment thereof comprises an X543D mutation of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262, wherein X represents any amino acid.

70. The Cas9 protein of any one of claims 56-69, wherein the amino acid sequence of the Cas9 protein or the fragment thereof comprises an E543D mutation of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262.

71. The Cas9 protein of any of claims 56-70, wherein the amino acid sequence of the Cas9 protein or the fragment thereof comprises the mutations X480K, X543D, and X1219V of the amino acid sequence provided in SEQ ID NO: 9, or corresponding mutations in any of the amino acid sequences provided in SEQ ID NOs: 10-262, wherein X represents any amino acid.

72. The Cas9 protein of any of claims 56-70, wherein the amino acid sequence of the Cas9 protein or the fragment thereof comprises the mutations X262T, X409I, X480K, X543D, X694I, and X1219V of the amino acid sequence provided in SEQ ID NO: 9, or

corresponding mutations in any of the amino acid sequences provided in SEQ ID NOs: 10- 262, wherein X represents any amino acid.

73. The Cas9 protein of any of claims 56-70, wherein the amino acid sequence of the Cas9 protein or the fragment thereof comprises the mutations X294R, X480K, X543D, X1219V, X1256K, and X1362P of the amino acid sequence provided in SEQ ID NO: 9, or corresponding mutations in any of the amino acid sequences provided in SEQ ID NOs: 10- 262, wherein X represents any amino acid.

74. The Cas9 protein of any of claims 56-70, wherein the amino acid sequence of the Cas9 protein or the fragment thereof comprises the mutations X294R, X480K, X543D, X1219V, and X1256K of the amino acid sequence provided in SEQ ID NO: 9, or corresponding mutations in any of the amino acid sequences provided in SEQ ID NOs: 10-262, wherein X represents any amino acid.

75. The Cas9 protein of any of claims 56-70, wherein the amino acid sequence of the Cas9 protein or the fragment thereof comprises the mutations X267G, X294R, X480K, X543D, X1219V, X1224K, and X1256K of the amino acid sequence provided in SEQ ID NO: 9, or corresponding mutations in any of the amino acid sequences provided in SEQ ID NOs: 10- 262, wherein X represents any amino acid.

76. The Cas9 protein of any of claims 56-70, wherein the amino acid sequence of the Cas9 protein or the fragment thereof comprises the mutations X262T, X405I, X409I, X480K, X543D, X694I, and X1219V of the amino acid sequence provided in SEQ ID NO: 9, or corresponding mutations in any of the amino acid sequences provided in SEQ ID NOs: 10- 262, wherein X represents any amino acid.

77. The Cas9 protein of any of claims 56-70, wherein the amino acid sequence of the Cas9 protein or the fragment thereof comprises the mutations E480K, E543D, and E1219V of the amino acid sequence provided in SEQ ID NO: 9, or corresponding mutations in any of the amino acid sequences provided in SEQ ID NOs: 10-262.

78. The Cas9 protein of any of claims 56-70, wherein the amino acid sequence of the Cas9 protein or the fragment thereof comprises the mutations A262T, S409I, E480K, E543D, M694I, and E1219V of the amino acid sequence provided in SEQ ID NO: 9, or

corresponding mutations in any of the amino acid sequences provided in SEQ ID NOs: 10- 262.

79. The Cas9 protein of any of claims 56-70, wherein the amino acid sequence of the Cas9 protein or the fragment thereof comprises the mutations K294R, E480K, E543D, E1219V, Q1256K, and L1362P of the amino acid sequence provided in SEQ ID NO: 9, or corresponding mutations in any of the amino acid sequences provided in SEQ ID NOs: 10- 262.

80. The Cas9 protein of any of claims 56-70, wherein the amino acid sequence of the Cas9 protein or the fragment thereof comprises the mutations K294R, E480K, E543D, E1219V, and Q1256K of the amino acid sequence provided in SEQ ID NO: 9, or corresponding mutations in any of the amino acid sequences provided in SEQ ID NOs: 10-262.

81. The Cas9 protein of any of claims 56-70, wherein the amino acid sequence of the Cas9 protein or the fragment thereof comprises the mutations S267G, K294R, E480K, E543DE1219V, N1224K, and Q1256K of the amino acid sequence provided in SEQ ID NO: 9, or corresponding mutations in any of the amino acid sequences provided in SEQ ID NOs: 10-262.

82. The Cas9 protein of any of claims 56-70, wherein the amino acid sequence of the Cas9 protein or the fragment thereof comprises the mutations A262T, F405I, S409I, E480K, E543D, M694I, and E1219V of the amino acid sequence provided in SEQ ID NO: 9, or corresponding mutations in any of the amino acid sequences provided in SEQ ID NOs: 10- 262.

83. The Cas9 protein of any one of claims 57-82, wherein the amino acid sequence of the HNH domain is at least 80%, at least 85%, at least 90%, at least 92%, at least 95%, at least 96%), at least 97%, at least 98%>, at least 99%, or at least 99.5% identical to the amino acid sequence of the HNH domain of any of SEQ ID NOs: 9-262.

84. The Cas9 protein of any one of claims 57-83, wherein the amino acid sequence of the HNH domain is identical to the amino acid sequence of the HNH domain of SEQ ID NO: 9.

85. The Cas9 protein of any one of claims 57-84, wherein the amino acid sequence of the RuvC domain is at least 80%, at least 85%, at least 90%, at least 92%, at least 95%, at least 96%), at least 97%, at least 98%, at least 99%, or at least 99.5% identical to the amino acid sequence of the RuvC domain of any of SEQ ID NOs: 9-262.

86. The Cas9 protein of any one of claims 57-85, wherein the amino acid sequence of the RuvC domain is identical to the amino acid sequence of the RuvC domain of SEQ ID NO: 9.

87. The Cas9 protein of any one of claims 56-86, wherein the Cas9 protein or the fragment thereof comprises at D10A and/or a H840A mutation in the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262.

88. The Cas9 protein of any one of claims 56-86, wherein the Cas9 protein or the fragment thereof comprises a D10X₁ and/or a H840X₂ mutation of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262, wherein Xi is any amino acid except for D and wherein X₂ is any amino acid except for H.

89. The Cas9 protein of any one of claims 56-88, wherein the Cas9 protein or the fragment thereof comprises an DIOA mutation of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262.

90. The Cas9 protein of claim 89, wherein the Cas9 protein or the fragment thereof comprises an H at amino acid residue 840 of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding residue in any of the amino acid sequences provided in SEQ ID NOs: 10-262.

91. The Cas9 protein of any one of claims 56-89, wherein the Cas9 protein or the fragment thereof comprises an H840A mutation of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262.

92. The Cas9 protein of claim 91, wherein the Cas9 protein or the fragment thereof comprises an D at amino acid residue 10 of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding residue in any of the amino acid sequences provided in SEQ ID NOs: 10-262.

93. A recombinant Cas9 protein comprising an amino acid sequence that is at least 80%, identical to the amino acid sequence of a Cas9 as provided by any one of SEQ ID NOs: 9- 262,

wherein the amino acid sequence of the Cas9 protein comprises at least one, at least two, at least three, at least four, at least five, at least six, or at least seven mutations in an amino acid residue selected from the group consisting of amino acid residues 122, 137, 182, 262, 294, 409, 480, 543, 660, 694, 1219, and 1329 of the amino acid sequence provided in SEQ ID NO: 9, or in a corresponding amino acid residue in any of the amino acid sequences provided in SEQ ID NOs: 10-262, and

wherein the amino acid sequence of the recombinant Cas9 protein is not identical to the amino acid sequence of a naturally occurring Cas9 protein.

94. The Cas9 protein of claim 93, wherein the Cas9 protein comprises a RuvC and an HNH domain.

95. The Cas9 protein of claim 93 or 94, wherein the amino acid sequence of the Cas9 protein comprises at least one, at least two, at least three, at least four, at least five, at least six, or at least seven mutations selected from the group consisting of X262T, X294R, X409I, X480K, X543D, X694I, and X1219V of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10- 262, wherein X represents any amino acid.

96. The Cas9 protein of any one of claims 93-95, wherein the amino acid sequence of the Cas9 protein comprises at least one, at least two, at least three, at least four, at least five, at least six, or at least seven mutations selected from the group consisting of A262T, K294R, S409I, E480K, E543D, M694I, or E1219V of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262.

97. The Cas9 protein of any one of claims 93-96, wherein the amino acid sequence of the Cas9 protein comprises an X1219V mutation of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262.

98. The Cas9 protein of any one of claims 93-97, wherein the amino acid sequence of the Cas9 protein comprises an E1219V mutation of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262.

99. The Cas9 protein of any one of claims 94-98, wherein the amino acid sequence of the HNH domain is at least 80%, at least 85%, at least 90%, at least 92%, at least 95%, at least 96%), at least 97%, at least 98%>, at least 99%, or at least 99.5% identical to the amino acid sequence of the HNH domain of any of SEQ ID NOs: 9-262.

100. The Cas9 protein of any one of claims 94-99, wherein the amino acid sequence of the HNH domain is identical to the amino acid sequence of the HNH domain of SEQ ID NO: 9.

101. The Cas9 protein of any one of claims 94-100, wherein the amino acid sequence of the RuvC domain is at least 80%, at least 85%, at least 90%, at least 92%, at least 95%, at least 96%), at least 97%, at least 98%, at least 99%, or at least 99.5% identical to the amino acid sequence of the RuvC domain of any of SEQ ID NOs: 9-262.

102. The Cas9 protein of any one of claims 94-101, wherein the amino acid sequence of the RuvC domain is identical to the amino acid sequence of the RuvC domain of SEQ ID NO: 9.

103. The Cas9 protein of any one of claims 93-102, wherein the Cas9 protein comprises a DIOA and/or a H840A mutation of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10- 262.

104. The Cas9 protein of any one of claims 93-102, wherein the Cas9 protein comprises an DIOA mutation of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262.

105. The Cas9 protein of claim 104, wherein the Cas9 protein comprises an H at amino acid residue 840 of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding residue in any of the amino acid sequences provided in SEQ ID NOs: 10-262.

106. The Cas9 protein of any one of claims 93-105, wherein the Cas9 protein exhibits an increased activity on a target sequence that does not comprise the canonical PAM (5 '-NOGS ') at its 3' end as compared to Streptococcus pyogenes Cas9 as provided by SEQ ID NO: 9.

107. A recombinant Cas9 protein comprising an amino acid sequence that is at least 90% identical to the amino acid sequence of Streptococcus pyogenes Cas9 as provided by SEQ ID NO: 9, or to a fragment thereof, comprising the RuvC and HNH domains of SEQ ID NO: 9, wherein the amino acid sequence of the Cas9 protein comprises at least one, at least two, at least three, at least four, at least five, at least six, or at least seven mutations in an amino acid residue selected from the group consisting of amino acid residues 122, 137, 182, 262, 294, 409, 480, 543, 660, 694, 1219, and 1329 of the amino acid sequence provided in SEQ ID NO: 9,

wherein the amino acid sequence of the recombinant Cas9 protein is not identical to the amino acid sequence of a naturally occurring Cas9 protein, and

wherein the recombinant Cas9 protein exhibits an increased activity on a target sequence that does not comprise the canonical PAM (5'-NGG-3 ') at its 3' end as compared to Streptococcus pyogenes Cas9 as provided by SEQ ID NO: 9.

108. The Cas9 protein of claim 107, wherein the Cas9 protein comprises a RuvC and an HNH domain.

109. The Cas9 protein of claim 107 or 108, wherein the Cas9 protein exhibits an activity on a target sequence having a 3' end that is not directly adjacent to the canonical PAM sequence (5'-NGG-3 ') that is at least 5-fold, at least 10-fold, at least 50-fold, at least 100-fold, at least 500-fold, at least 1,000-fold, at least 5,000-fold, at least 10,000-fold, at least 50,000-fold, at least 100,000-fold, at least 500,000-fold, or at least 1,000,000-fold increased as compared to the activity of Streptococcus pyogenes Cas9 as provided by SEQ ID NO: 9 on the same target sequence.

110. The Cas9 protein of claim 109, wherein the 3' end of the target sequence is directly adjacent to an AGC, GAG, TTT, GTG, or CAA sequence.

111. The Cas9 protein of any one of claims 107-110, wherein the Cas9 protein activity is measured by a nuclease assay, a deamination assay, or a transcriptional activation assay.

112. The Cas9 protein of claim 111, wherein the transcriptional activation assay is a GFP activation assay.

113. The Cas9 protein of any one of claims 107-112, wherein the amino acid sequence of the Cas9 protein comprises at least one, at least two, at least three, at least four, at least five, at least six, or at least seven mutations selected from the group consisting of X262T, X294R, X409I, X480K, X543D, X694I, and X1219V of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262, wherein X represents any amino acid.

114. The Cas9 protein of any one of claims 107-113, wherein the amino acid sequence of the Cas9 protein or the fragment thereof comprises at least one, at least two, at least three, at least four, at least five, at least six, or at least seven mutations selected from the group consisting of A262T, K294R, S409I, E480K, E543D, M694I, or E1219V of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262.

115. The Cas9 protein of any one of claims 107-114, wherein the amino acid sequence of the Cas9 protein or the fragment thereof comprises an X1219 mutation of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262.

116. The Cas9 protein of any one of claims 107-115, wherein the amino acid sequence of the Cas9 protein or the fragment thereof comprises an X1219V mutation of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262.

117. The Cas9 protein of any one of claims 108-116, wherein the amino acid sequence of the HNH domain is at least 80%, at least 85%, at least 90%, at least 92%, at least 95%, at least 96%), at least 97%, at least 98%>, at least 99%, or at least 99.5% identical to the amino acid sequence of the HNH domain of any of SEQ ID NOs: 9-262.

118. The Cas9 protein of any one of claims 108-117, wherein the amino acid sequence of the HNH domain is identical to the amino acid sequence of the HNH domain of SEQ ID NO: 9.

119. The Cas9 protein of any one of claims 108-118, wherein the amino acid sequence of the RuvC domain is at least 80%, at least 85%, at least 90%, at least 92%, at least 95%, at least 96%), at least 97%, at least 98%, at least 99%, or at least 99.5% identical to the amino acid sequence of the RuvC domain of any of SEQ ID NOs: 9-262.

120. The Cas9 protein of any one of claims 108-119, wherein the amino acid sequence of the RuvC domain is identical to the amino acid sequence of the RuvC domain of SEQ ID NO: 9.

121. The Cas9 protein of any one of claims 107-120, wherein the Cas9 protein or the fragment thereof comprises at D10A and/or a H840A mutation in the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262.

122. The Cas9 protein of any one of claims 107-121, wherein the Cas9 protein comprises an D10A mutation of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262.

123. The Cas9 protein of claim 122, wherein the Cas9 protein comprises an H at amino acid residue 840 of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding residue in any of the amino acid sequences provided in SEQ ID NOs: 10-262.

124. A recombinant Cas9 protein comprising an amino acid sequence that is at least 80%, at least 85%, at least 90%, at least 92%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%), or at least 99.5% identical to the amino acid sequence of a Cas9 as provided by any one of SEQ ID NOs: 9-262,

wherein the amino acid sequence of the Cas9 protein comprises at least one, at least two, at least three, at least four, at least five, at least six, at least seven, at least eight, at least nine, or at least ten mutations in an amino acid residue selected from the group consisting of amino acid residues 23, 108, 115, 141, 180, 230, 257, 262, 267, 284, 294, 324, 409, 455, 466, 474, 480, 543, 554, 654, 694, 711, 727, 763, 1063, 1100, 1219, 1244, 1256, 1289, and 1323 of the amino acid sequence provided in SEQ ID NO: 9, or in a corresponding amino acid residue in any of the amino acid sequences provided in SEQ ID NOs: 10-262, and

wherein the amino acid sequence of the recombinant Cas9 protein is not identical to the amino acid sequence of a naturally occurring Cas9 protein.

125. The Cas9 protein of claim 124, wherein the Cas9 protein comprises a RuvC and an HNH domain.

126. The Cas9 protein of claim 124 or 125, wherein the amino acid sequence of the Cas9 protein comprises at least one, at least two, at least three, at least four, at least five, at least six, at least seven, at least eight, at least nine, or at least ten mutations selected from the group consisting of X23N, X108G, X115H, X141Q, X180N, X230S, X257N, X262T, X267G, X284N, X294R, X324L, X409I, X455F, X466A, X474I, X480K, X543D, X554R, X654L, X694I, X711E, X727P, X763I, X1063V, XI 1001, X1219V, X1244N, X1256K, X1289Q, and X1323S of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262, wherein X represents any amino acid.

127. The Cas9 protein of any one of claims 124-126, wherein the amino acid sequence of the Cas9 protein comprises at least one, at least two, at least three, at least four, at least five, at least six, at least seven, at lest eight, at least nine, or at least ten mutations selected from the group consisting of D23N, E108G, R115H, K141Q, D180N, P230S, D257N, A262T, S267G, D284N, K294R, R324L, S409I, L455F, T466A, T474I, E480K, E543D, K554R, R654L, M694I, A711E, L727P, M763I, I1063V, VI 1001, E1219V, K1244N, Q1256K, K1289Q, and A1323S of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262.

128. The Cas9 protein of any of claims 124-127, wherein the amino acid sequence of the Cas9 protein comprises the mutations XI 15H, X141Q, X267G, X294R, X480K, X543D, X1219V, and X1256K of the amino acid sequence provided in SEQ ID NO: 9, or

corresponding mutations in any of the amino acid sequences provided in SEQ ID NOs: 10- 262, wherein X represents any amino acid.

129. The Cas9 protein of any of claims 124-127, wherein the amino acid sequence of the Cas9 protein comprises the mutations X267G, X294R, X480K, X543D, X1219V, and X1256K of the amino acid sequence provided in SEQ ID NO: 9, or corresponding mutations in any of the amino acid sequences provided in SEQ ID NOs: 10-262, wherein X represents any amino acid.

130. The Cas9 protein of any of claims 124-127, wherein the amino acid sequence of the Cas9 protein comprises the mutations X23N, X108G, X262T, X409I, X480K, X543D, X694I, X727P, X1219V, and X1289Q of the amino acid sequence provided in SEQ ID NO: 9, or corresponding mutations in any of the amino acid sequences provided in SEQ ID NOs: 10-262, wherein X represents any amino acid.

131. The Cas9 protein of any of claims 124-127, wherein the amino acid sequence of the Cas9 protein comprises the mutations X257N, X267G, X294R, X466A, X480K, X543D, X1063V, X1219V, and X1256K of the amino acid sequence provided in SEQ ID NO: 9, or corresponding mutations in any of the amino acid sequences provided in SEQ ID NOs: 10- 262, wherein X represents any amino acid.

132. The Cas9 protein of any of claims 124-127, wherein the amino acid sequence of the Cas9 protein comprises the mutations X409I, X455F, X480K, X543D, X654L, XI 1001, X1219V, and X1323S of the amino acid sequence provided in SEQ ID NO: 9, or corresponding mutations in any of the amino acid sequences provided in SEQ ID NOs: 10- 262, wherein X represents any amino acid.

133. The Cas9 protein of any of claims 124-127, wherein the amino acid sequence of the Cas9 protein comprises the mutations X267G, X294R, X480K, X543D, X1219V, and X1256K of the amino acid sequence provided in SEQ ID NO: 9, or corresponding mutations in any of the amino acid sequences provided in SEQ ID NOs: 10-262, wherein X represents any amino acid.

134. The Cas9 protein of any of claims 124-127, wherein the amino acid sequence of the Cas9 protein comprises the mutations X262T, X324L, X409I, X480K, X543D, X694I, and X1219V of the amino acid sequence provided in SEQ ID NO: 9, or corresponding mutations in any of the amino acid sequences provided in SEQ ID NOs: 10-262, wherein X represents any amino acid.

135. The Cas9 protein of any of claims 124-127, wherein the amino acid sequence of the Cas9 protein comprises the mutations X294R, X480K, X543D, X71 IE, XI 219V, and X1256K of the amino acid sequence provided in SEQ ID NO: 9, or corresponding mutations in any of the amino acid sequences provided in SEQ ID NOs: 10-262, wherein X represents any amino acid.

136. The Cas9 protein of any of claims 124-127, wherein the amino acid sequence of the Cas9 protein comprises the mutations X230S, X267G, X294R, X480K, X543D, X1219V, and X1256K of the amino acid sequence provided in SEQ ID NO: 9, or corresponding mutations in any of the amino acid sequences provided in SEQ ID NOs: 10-262, wherein X represents any amino acid.

137. The Cas9 protein of any of claims 124-127, wherein the amino acid sequence of the Cas9 protein comprises the mutations X180N, X284N, X474I, X480K, X543D, X554R, X763I, X1219V, and X1244N of the amino acid sequence provided in SEQ ID NO: 9, or corresponding mutations in any of the amino acid sequences provided in SEQ ID NOs: 10- 262, wherein X represents any amino acid.

138. The Cas9 protein of any of claims 124-127, wherein the amino acid sequence of the Cas9 protein comprises the mutations X262T, X409I, X480K, X543D, X694I, and X1219V of the amino acid sequence provided in SEQ ID NO: 9, or corresponding mutations in any of the amino acid sequences provided in SEQ ID NOs: 10-262, wherein X represents any amino acid.

139. The Cas9 protein of any of claims 124-127, wherein the amino acid sequence of the Cas9 protein comprises the mutations X267G, X294R, X480K, X543D, X1219V, and X1256K of the amino acid sequence provided in SEQ ID NO: 9, or corresponding mutations in any of the amino acid sequences provided in SEQ ID NOs: 10-262, wherein X represents any amino acid.

140. The Cas9 protein of any of claims 124-127, wherein the amino acid sequence of the Cas9 protein comprises the mutations X230S, X267G, X294R, X480K, X543D, X1219V, and X1256K of the amino acid sequence provided in SEQ ID NO: 9, or corresponding mutations in any of the amino acid sequences provided in SEQ ID NOs: 10-262, wherein X represents any amino acid.

141. The Cas9 protein of any of claims 124-127, wherein the amino acid sequence of the Cas9 protein comprises the mutations X267G, X294R, and X1256K of the amino acid sequence provided in SEQ ID NO: 9, or corresponding mutations in any of the amino acid sequences provided in SEQ ID NOs: 10-262, wherein X represents any amino acid.

142. The Cas9 protein of any of claims 124-127, wherein the amino acid sequence of the Cas9 protein comprises the mutations X262T, and X409I of the amino acid sequence provided in SEQ ID NO: 9, or corresponding mutations in any of the amino acid sequences provided in SEQ ID NOs: 10-262, wherein X represents any amino acid.

143. The Cas9 protein of any of claims 124-127, wherein the amino acid sequence of the Cas9 protein comprises the mutations Rl 15H, K141Q, S267G, K294R, E480K, E543D, E1219V, and Q1256K of the amino acid sequence provided in SEQ ID NO: 9, or

corresponding mutations in any of the amino acid sequences provided in SEQ ID NOs: 10- 262.

144. The Cas9 protein of any of claims 124-127, wherein the amino acid sequence of the Cas9 protein comprises the mutations S267G, K294R, E480K, E543D, E1219V, and Q1256K of the amino acid sequence provided in SEQ ID NO: 9, or corresponding mutations in any of the amino acid sequences provided in SEQ ID NOs: 10-262.

145. The Cas9 protein of any of claims 124-127, wherein the amino acid sequence of the Cas9 protein comprises the mutations D23N, E108G, A262T, S409I, E480K, E543D, M694I, L727P, E1219V, and K1289Q of the amino acid sequence provided in SEQ ID NO: 9, or corresponding mutations in any of the amino acid sequences provided in SEQ ID NOs: 10- 262.

146. The Cas9 protein of any of claims 124-127, wherein the amino acid sequence of the Cas9 protein comprises the mutations D257N, S267G, K294R, T466A, E480K, E543D, I1063V, E1219V, and Q1256K of the amino acid sequence provided in SEQ ID NO: 9, or corresponding mutations in any of the amino acid sequences provided in SEQ ID NOs: 10- 262.

147. The Cas9 protein of any of claims 124-127, wherein the amino acid sequence of the Cas9 protein comprises the mutations S409I, L455F, E480K, E543D, R654L, VI 1001, E1219V, and A1323S of the amino acid sequence provided in SEQ ID NO: 9, or

corresponding mutations in any of the amino acid sequences provided in SEQ ID NOs: 10- 262.

148. The Cas9 protein of any of claims 124-127, wherein the amino acid sequence of the Cas9 protein comprises the mutations S267G, K294R, E480K, E543D, E1219V, and Q1256K of the amino acid sequence provided in SEQ ID NO: 9, or corresponding mutations in any of the amino acid sequences provided in SEQ ID NOs: 10-262.

149. The Cas9 protein of any of claims 124-127, wherein the amino acid sequence of the Cas9 protein comprises the mutations A262T, R324L, S409I, E480K, E543D, M694I, and E1219V of the amino acid sequence provided in SEQ ID NO: 9, or corresponding mutations in any of the amino acid sequences provided in SEQ ID NOs: 10-262.

150. The Cas9 protein of any of claims 124-127, wherein the amino acid sequence of the Cas9 protein comprises the mutations K294R, E480K, E543D, A71 IE, E1219V, and

Q1256K of the amino acid sequence provided in SEQ ID NO: 9, or corresponding mutations in any of the amino acid sequences provided in SEQ ID NOs: 10-262.

151. The Cas9 protein of any of claims 124-127, wherein the amino acid sequence of the Cas9 protein comprises the mutations P230S, S267G, K294R, E480K, E543D, E1219V, and Q1256K of the amino acid sequence provided in SEQ ID NO: 9, or corresponding mutations in any of the amino acid sequences provided in SEQ ID NOs: 10-262.

152. The Cas9 protein of any of claims 124-127, wherein the amino acid sequence of the Cas9 protein comprises the mutations D180N, D284N, T474I, E480K, E543D, K554R, M763I, E1219V, and K1244N of the amino acid sequence provided in SEQ ID NO: 9, or corresponding mutations in any of the amino acid sequences provided in SEQ ID NOs: 10- 262.

153. The Cas9 protein of any of claims 124-127, wherein the amino acid sequence of the Cas9 protein comprises the mutations A262T, S409I, E480K, E543D, M694I, and E1219V of the amino acid sequence provided in SEQ ID NO: 9, or corresponding mutations in any of the amino acid sequences provided in SEQ ID NOs: 10-262.

154. The Cas9 protein of any of claims 124-127, wherein the amino acid sequence of the Cas9 protein comprises the mutations S267G, K294R, E480K, E543D, E1219V, and Q1256K of the amino acid sequence provided in SEQ ID NO: 9, or corresponding mutations in any of the amino acid sequences provided in SEQ ID NOs: 10-262.

155. The Cas9 protein of any of claims 124-127, wherein the amino acid sequence of the Cas9 protein comprises the mutations P230S, S267G, K294R, E480K, E543D, E1219V, and Q1256K of the amino acid sequence provided in SEQ ID NO: 9, or corresponding mutations in any of the amino acid sequences provided in SEQ ID NOs: 10-262.

156. The Cas9 protein of any of claims 124-127, wherein the amino acid sequence of the Cas9 protein comprises the mutations S267G, K294R, and Q1256K of the amino acid sequence provided in SEQ ID NO: 9, or corresponding mutations in any of the amino acid sequences provided in SEQ ID NOs: 10-262.

157. The Cas9 protein of any of claims 124-127, wherein the amino acid sequence of the Cas9 protein comprises the mutations A262T, and S409I of the amino acid sequence provided in SEQ ID NO: 9, or corresponding mutations in any of the amino acid sequences provided in SEQ ID NOs: 10-262.

158. The Cas9 protein of any one of claims 124-157, wherein the amino acid sequence of the HNH domain is at least 80%, at least 85%, at least 90%, at least 92%, at least 95%, at least 96%), at least 97%, at least 98%>, at least 99%, or at least 99.5% identical to the amino acid sequence of the HNH domain of any of SEQ ID NOs: 9-262.

159. The Cas9 protein of any one of claims 125-158, wherein the amino acid sequence of the HNH domain is identical to the amino acid sequence of the HNH domain of SEQ ID NO: 9.

160. The Cas9 protein of any one of claims 125-159, wherein the amino acid sequence of the RuvC domain is at least 80%, at least 85%, at least 90%, at least 92%, at least 95%, at least 96%), at least 97%, at least 98%, at least 99%, or at least 99.5% identical to the amino acid sequence of the RuvC domain of any of SEQ ID NOs: 9-262.

161. The Cas9 protein of any one of claims 125-160, wherein the amino acid sequence of the RuvC domain is identical to the amino acid sequence of the RuvC domain of SEQ ID NO: 9.

162. The Cas9 protein of any one of claims 124-161, wherein the Cas9 protein comprises a D10A and/or a H840A mutation of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10- 262.

163. The Cas9 protein of any one of claims 124-162, wherein the Cas9 protein comprises a DlOXi and/or a H840X₂ mutation of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10- 262, wherein X₁ is any amino acid except for D and wherein X₂ is any amino acid except for H.

164. The Cas9 protein of any one of claims 124-163, wherein the Cas9 protein comprises an D10A mutation of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262.

165. The Cas9 protein of claim 164, wherein the Cas9 protein comprises an H at amino acid residue 840 of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding residue in any of the amino acid sequences provided in SEQ ID NOs: 10-262.

166. The Cas9 protein of any one of claims 124-164, wherein the Cas9 protein comprises an H840A mutation of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262.

167. The Cas9 protein of claim 166, wherein the Cas9 protein comprises an D at amino acid residue 10 of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding residue in any of the amino acid sequences provided in SEQ ID NOs: 10-262.

168. The Cas9 protein of any one of claims 124-167, wherein the Cas9 protein exhibits an increased activity on a target sequence that does not comprise the canonical PAM (5 '-NOGS ') at its 3' end as compared to Streptococcus pyogenes Cas9 as provided by SEQ ID NO: 9.

169. A recombinant Cas9 protein comprising an amino acid sequence that is at least 90% identical to the amino acid sequence of Streptococcus pyogenes Cas9 as provided by SEQ ID NO: 9, or to a fragment thereof,

wherein the amino acid sequence of the Cas9 protein comprises at least one, at least two, at least three, at least four, at least five, at least six, at least seven, at least eight, at least nine, or at least ten mutations in an amino acid residue selected from the group consisting of amino acid residues 23, 108, 115, 141, 180, 230, 257, 262, 267, 284, 294, 324, 409, 455, 466, 474, 480, 543, 554, 654, 694, 711, 727, 763, 1063, 1100, 1219, 1244, 1256, 1289, and 1323 of the amino acid sequence provided in SEQ ID NO: 9,

wherein the amino acid sequence of the recombinant Cas9 protein is not identical to the amino acid sequence of a naturally occurring Cas9 protein, and

wherein the recombinant Cas9 protein exhibits an increased activity on a target sequence that does not comprise the canonical PAM (5'-NGG-3') at its 3' end as compared to Streptococcus pyogenes Cas9 as provided by SEQ ID NO: 9.

170. The Cas9 protein of claim 169, wherein the Cas9 protein comprises a RuvC and an HNH domain.

171. The Cas9 protein of claim 169 or 170, wherein the Cas9 protein exhibits an activity on a target sequence having a 3' end that is not directly adjacent to the canonical PAM sequence (5'-NGG-3 ') that is at least 5-fold, at least 10-fold, at least 50-fold, at least 100-fold, at least 500-fold, at least 1,000-fold, at least 5,000-fold, at least 10,000-fold, at least 50,000-fold, at least 100,000-fold, at least 500,000-fold, or at least 1,000,000-fold increased as compared to the activity of Streptococcus pyogenes Cas9 as provided by SEQ ID NO: 9 on the same target sequence.

172. The Cas9 protein of claim 171, wherein the 3' end of the target sequence is directly adjacent to an AGC, GAG, TTT, GTG, or CAA sequence.

173. The Cas9 protein of claim 171 or 172, wherein the 3' end of the target sequence is directly adjacent to a sequence selected from the group consisting of CAC, GAT, TAA, ACG, CGA, and CGT.

174. The Cas9 protein of any one of claims 169-173, wherein the Cas9 protein activity is measured by a nuclease assay, a deamination assay, or a transcriptional activation assay.

175. The Cas9 protein of claim 174, wherein the transcriptional activation assay is a GFP activation assay.

176. The Cas9 protein of any one of claims 169-175, wherein the amino acid sequence of the Cas9 protein comprises at least one, at least two, at least three, at least four, at least five, at least six, or at least seven mutations selected from the group consisting of X23N, X108G, X115H, X141Q, X180N, X230S, X257N, X262T, X267G, X284N, X294R, X324L, X409I, X455F, X466A, X474I, X480K, X543D, X554R, X654L, X694I, X711E, X727P, X763I, X1063V, XI 1001, X1219V, X1244N, X1256K, X1289Q, and X1323S of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262, wherein X represents any amino acid.

177. The Cas9 protein of any one of claims 169-176, wherein the amino acid sequence of the Cas9 protein or the fragment thereof comprises at least one, at least two, at least three, at least four, at least five, at least six, or at least seven mutations selected from the group consisting of D23N, E108G, R115H, K141Q, D180N, P230S, D257N, A262T, S267G, D284N, K294R, R324L, S409I, L455F, T466A, T474I, E480K, E543D, K554R, R654L, M694I, A711E, L727P, M7631, 11063 V, VI 1001, E1219V, K1244N, Q1256K, K1289Q, and A1323S of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262.

178. The Cas9 protein of any of claims 169-177, wherein the amino acid sequence of the Cas9 protein or the fragment thereof comprises the mutations XI 15H, X141Q, X267G, X294R, X480K, X543D, X1219V, and X1256K of the amino acid sequence provided in SEQ ID NO: 9, or corresponding mutations in any of the amino acid sequences provided in SEQ ID NOs: 10-262, wherein X represents any amino acid.

179. The Cas9 protein of any of claims 169-177, wherein the amino acid sequence of the Cas9 protein or the fragment thereof comprises the mutations X267G, X294R, X480K, X543D, X1219V, and X1256K of the amino acid sequence provided in SEQ ID NO: 9, or corresponding mutations in any of the amino acid sequences provided in SEQ ID NOs: 10- 262, wherein X represents any amino acid.

180. The Cas9 protein of any of claims 169-177, wherein the amino acid sequence of the Cas9 protein or the fragment thereof comprises the mutations X23N, X108G, X262T, X409I, X480K, X543D, X694I, X727P, X1219V, and X1289Q of the amino acid sequence provided in SEQ ID NO: 9, or corresponding mutations in any of the amino acid sequences provided in SEQ ID NOs: 10-262, wherein X represents any amino acid.

181. The Cas9 protein of any of claims 169-177, wherein the amino acid sequence of the Cas9 protein or the fragment thereof comprises the mutations X257N, X267G, X294R, X466A, X480K, X543D, X1063V, X1219V, and X1256K of the amino acid sequence provided in SEQ ID NO: 9, or corresponding mutations in any of the amino acid sequences provided in SEQ ID NOs: 10-262, wherein X represents any amino acid.

182. The Cas9 protein of any of claims 169-177, wherein the amino acid sequence of the Cas9 protein or the fragment thereof comprises the mutations X409I, X455F, X480K, X543D, X654L, XI 1001, X1219V, and X1323S of the amino acid sequence provided in SEQ ID NO: 9, or corresponding mutations in any of the amino acid sequences provided in SEQ ID NOs: 10-262, wherein X represents any amino acid.

183. The Cas9 protein of any of claims 169-177, wherein the amino acid sequence of the Cas9 protein or the fragment thereof comprises the mutations X267G, X294R, X480K, X543D, X1219V, and X1256K of the amino acid sequence provided in SEQ ID NO: 9, or corresponding mutations in any of the amino acid sequences provided in SEQ ID NOs: 10- 262, wherein X represents any amino acid.

184. The Cas9 protein of any of claims 169-177, wherein the amino acid sequence of the Cas9 protein or the fragment thereof comprises the mutations X262T, X324L, X409I, X480K, X543D, X694I, and X1219V of the amino acid sequence provided in SEQ ID NO: 9, or corresponding mutations in any of the amino acid sequences provided in SEQ ID NOs: 10- 262, wherein X represents any amino acid.

185. The Cas9 protein of any of claims 169-177, wherein the amino acid sequence of the Cas9 protein or the fragment thereof comprises the mutations X294R, X480K, X543D, X71 IE, X1219V, and X1256K of the amino acid sequence provided in SEQ ID NO: 9, or corresponding mutations in any of the amino acid sequences provided in SEQ ID NOs: 10- 262, wherein X represents any amino acid.

186. The Cas9 protein of any of claims 169-177, wherein the amino acid sequence of the Cas9 protein or the fragment thereof comprises the mutations X230S, X267G, X294R, X480K, X543D, X1219V, and X1256K of the amino acid sequence provided in SEQ ID NO: 9, or corresponding mutations in any of the amino acid sequences provided in SEQ ID NOs: 10-262, wherein X represents any amino acid.

187. The Cas9 protein of any of claims 169-177, wherein the amino acid sequence of the Cas9 protein or the fragment thereof comprises the mutations X180N, X284N, X474I, X480K, X543D, X554R, X763I, X1219V, and X1244N of the amino acid sequence provided in SEQ ID NO: 9, or corresponding mutations in any of the amino acid sequences provided in SEQ ID NOs: 10-262, wherein X represents any amino acid.

188. The Cas9 protein of any of claims 169-177, wherein the amino acid sequence of the Cas9 protein or the fragment thereof comprises the mutations X262T, X409I, X480K, X543D, X694I, and X1219V of the amino acid sequence provided in SEQ ID NO: 9, or corresponding mutations in any of the amino acid sequences provided in SEQ ID NOs: 10- 262, wherein X represents any amino acid.

189. The Cas9 protein of any of claims 169-177, wherein the amino acid sequence of the Cas9 protein or the fragment thereof comprises the mutations X267G, X294R, X480K, X543D, X1219V, and X1256K of the amino acid sequence provided in SEQ ID NO: 9, or corresponding mutations in any of the amino acid sequences provided in SEQ ID NOs: 10- 262, wherein X represents any amino acid.

190. The Cas9 protein of any of claims 169-177, wherein the amino acid sequence of the Cas9 protein or the fragment thereof comprises the mutations X230S, X267G, X294R, X480K, X543D, X1219V, and X1256K of the amino acid sequence provided in SEQ ID NO: 9, or corresponding mutations in any of the amino acid sequences provided in SEQ ID NOs: 10-262, wherein X represents any amino acid.

191. The Cas9 protein of any of claims 169-177, wherein the amino acid sequence of the Cas9 protein or the fragment thereof comprises the mutations X267G, X294R, and X1256K of the amino acid sequence provided in SEQ ID NO: 9, or corresponding mutations in any of the amino acid sequences provided in SEQ ID NOs: 10-262, wherein X represents any amino acid.

192. The Cas9 protein of any of claims 169-177, wherein the amino acid sequence of the Cas9 protein or the fragment thereof comprises the mutations X262T, and X409I of the amino acid sequence provided in SEQ ID NO: 9, or corresponding mutations in any of the amino acid sequences provided in SEQ ID NOs: 10-262, wherein X represents any amino acid.

193. The Cas9 protein of any of claims 169-177, wherein the amino acid sequence of the Cas9 protein or the fragment thereof comprises the mutations Rl 15H, K141Q, S267G, K294R, E480K, E543D, E1219V, and Q1256K of the amino acid sequence provided in SEQ ID NO: 9, or corresponding mutations in any of the amino acid sequences provided in SEQ ID NOs: 10-262.

194. The Cas9 protein of any of claims 169-177, wherein the amino acid sequence of the Cas9 protein or the fragment thereof comprises the mutations S267G, K294R, E480K, E543D, E1219V, and Q1256K of the amino acid sequence provided in SEQ ID NO: 9, or corresponding mutations in any of the amino acid sequences provided in SEQ ID NOs: 10- 262.

195. The Cas9 protein of any of claims 169-177, wherein the amino acid sequence of the Cas9 protein or the fragment thereof comprises the mutations D23N, E108G, A262T, S409I, E480K, E543D, M694I, L727P, E1219V, and K1289Q of the amino acid sequence provided in SEQ ID NO: 9, or corresponding mutations in any of the amino acid sequences provided in SEQ ID NOs: 10-262.

196. The Cas9 protein of any of claims 169-177, wherein the amino acid sequence of the Cas9 protein or the fragment thereof comprises the mutations D257N, S267G, K294R, T466A, E480K, E543D, I1063V, E1219V, and Q1256K of the amino acid sequence provided in SEQ ID NO: 9, or corresponding mutations in any of the amino acid sequences provided in SEQ ID NOs: 10-262.

197. The Cas9 protein of any of claims 169-177, wherein the amino acid sequence of the Cas9 protein or the fragment thereof comprises the mutations S409I, L455F, E480K, E543D, R654L, VI 1001, E1219V, and A1323S of the amino acid sequence provided in SEQ ID NO: 9, or corresponding mutations in any of the amino acid sequences provided in SEQ ID NOs: 10-262.

198. The Cas9 protein of any of claims 169-177, wherein the amino acid sequence of the Cas9 protein or the fragment thereof comprises the mutations S267G, K294R, E480K, E543D, E1219V, and Q1256K of the amino acid sequence provided in SEQ ID NO: 9, or corresponding mutations in any of the amino acid sequences provided in SEQ ID NOs: 10- 262.

199. The Cas9 protein of any of claims 169-177, wherein the amino acid sequence of the Cas9 protein or the fragment thereof comprises the mutations A262T, R324L, S409I, E480K, E543D, M694I, and E1219V of the amino acid sequence provided in SEQ ID NO: 9, or corresponding mutations in any of the amino acid sequences provided in SEQ ID NOs: 10- 262.

200. The Cas9 protein of any of claims 169-177, wherein the amino acid sequence of the Cas9 protein or the fragment thereof comprises the mutations K294R, E480K, E543D, A71 IE, E1219V, and Q1256K of the amino acid sequence provided in SEQ ID NO: 9, or corresponding mutations in any of the amino acid sequences provided in SEQ ID NOs: 10- 262.

201. The Cas9 protein of any of claims 169-177, wherein the amino acid sequence of the Cas9 protein or the fragment thereof comprises the mutations P230S, S267G, K294R, E480K, E543D, E1219V, and Q1256K of the amino acid sequence provided in SEQ ID NO: 9, or corresponding mutations in any of the amino acid sequences provided in SEQ ID NOs: 10-262.

202. The Cas9 protein of any of claims 169-177, wherein the amino acid sequence of the Cas9 protein or the fragment thereof comprises the mutations D180N, D284N, T474I, E480K, E543D, K554R, M763I, E1219V, and K1244N of the amino acid sequence provided in SEQ ID NO: 9, or corresponding mutations in any of the amino acid sequences provided in SEQ ID NOs: 10-262.

203. The Cas9 protein of any of claims 169-177, wherein the amino acid sequence of the Cas9 protein or the fragment thereof comprises the mutations A262T, S409I, E480K, E543D, M694I, and E1219V of the amino acid sequence provided in SEQ ID NO: 9, or

corresponding mutations in any of the amino acid sequences provided in SEQ ID NOs: 10- 262.

204. The Cas9 protein of any of claims 169-177, wherein the amino acid sequence of the Cas9 protein or the fragment thereof comprises the mutations S267G, K294R, E480K, E543D, E1219V, and Q1256K of the amino acid sequence provided in SEQ ID NO: 9, or corresponding mutations in any of the amino acid sequences provided in SEQ ID NOs: 10- 262.

205. The Cas9 protein of any of claims 169-177, wherein the amino acid sequence of the Cas9 protein or the fragment thereof comprises the mutations P230S, S267G, K294R, E480K, E543D, E1219V, and Q1256K of the amino acid sequence provided in SEQ ID NO: 9, or corresponding mutations in any of the amino acid sequences provided in SEQ ID NOs: 10-262.

206. The Cas9 protein of any of claims 169-177, wherein the amino acid sequence of the Cas9 protein or the fragment thereof comprises the mutations S267G, K294R, and Q1256K of the amino acid sequence provided in SEQ ID NO: 9, or corresponding mutations in any of the amino acid sequences provided in SEQ ID NOs: 10-262.

207. The Cas9 protein of any of claims 169-177, wherein the amino acid sequence of the Cas9 protein or the fragment thereof comprises the mutations A262T, and S409I of the amino acid sequence provided in SEQ ID NO: 9, or corresponding mutations in any of the amino acid sequences provided in SEQ ID NOs: 10-262.

208. The Cas9 protein of any one of claims 170-207, wherein the amino acid sequence of the HNH domain is at least 80%, at least 85%, at least 90%, at least 92%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or at least 99.5% identical to the amino acid sequence of the HNH domain of any of SEQ ID NOs: 9-262.

209. The Cas9 protein of any one of claims 170-208, wherein the amino acid sequence of the HNH domain is identical to the amino acid sequence of the HNH domain of SEQ ID NO: 9.

210. The Cas9 protein of any one of claims 170-209, wherein the amino acid sequence of the RuvC domain is at least 80%, at least 85%, at least 90%, at least 92%, at least 95%, at least 96%), at least 97%, at least 98%, at least 99%, or at least 99.5% identical to the amino acid sequence of the RuvC domain of any of SEQ ID NOs: 9-262.

211. The Cas9 protein of any one of claims 170-210, wherein the amino acid sequence of the RuvC domain is identical to the amino acid sequence of the RuvC domain of SEQ ID NO: 9.

212. The Cas9 protein of any one of claims 169-211, wherein the Cas9 protein or the fragment thereof comprises at D10A and/or a H840A mutation in the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262.

213. The Cas9 protein of any one of claims 169-211, wherein the Cas9 protein or the fragment thereof comprises a D10X₁ and/or a H840X₂ mutation of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262, wherein X₁ is any amino acid except for D and wherein X₂ is any amino acid except for H.

214. The Cas9 protein of any one of claims 169-213, wherein the Cas9 protein or the fragment thereof comprises an D10A mutation of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262.

215. The Cas9 protein of claim 214, wherein the Cas9 protein or the fragment thereof comprises an H at amino acid residue 840 of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding residue in any of the amino acid sequences provided in SEQ ID NOs: 10-262.

216. The Cas9 protein of any one of claims 169-214, wherein the Cas9 protein or the fragment thereof comprises an H840A mutation of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262.

217. The Cas9 protein of claim 216, wherein the Cas9 protein or the fragment thereof comprises an D at amino acid residue 10 of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding residue in any of the amino acid sequences provided in SEQ ID NOs: 10-262.

218. A recombinant Cas9 protein comprising an amino acid sequence that is at least 80%, at least 85%, at least 90%, at least 92%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%), or at least 99.5% identical to the amino acid sequence of a Cas9 as provided by any one of SEQ ID NOs: 9-262,

wherein the amino acid sequence of the Cas9 protein comprises at least one, at least two, at least three, at least four, at least five, at least six, at least seven, at least eight, or at least nine mutations in an amino acid residue selected from the group consisting of amino acid residues 175, 230, 257, 267, 294, 466, 480, 543, 711, 1063, 1207, 1219, and 1256 of the amino acid sequence provided in SEQ ID NO: 9, or in a corresponding amino acid residue in any of the amino acid sequences provided in SEQ ID NOs: 10-262, and

wherein the amino acid sequence of the recombinant Cas9 protein is not identical to the amino acid sequence of a naturally occurring Cas9 protein.

219. The Cas9 protein of claim 218, wherein the Cas9 protein comprises a RuvC and an HNH domain.

220. The Cas9 protein of claim 218 or 219, wherein the amino acid sequence of the Cas9 protein comprises at least one, at least two, at least three, at least four, at least five, at least six, at least seven, at least eight, or at least nine mutations selected from the group consisting of X175T, X230F, X257N, X267G, X294R, X466A, X480K, X543D, X711E, X1207G, X1063V, X1219V, and X1256K of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10- 262, wherein X represents any amino acid.

221. The Cas9 protein of any one of claims 218-220, wherein the amino acid sequence of the Cas9 protein comprises at least one, at least two, at least three, at least four, at least five, at least six, at least seven, at lest eight, or at least nine mutations selected from the group consisting of N175T, P230F, D257N, S267G, K294R, T466A, E480K, E543D, A711E, E1207G, I1063V, E1219V, and Q1256K of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262.

222. The Cas9 protein of any of claims 218-221, wherein the amino acid sequence of the Cas9 protein comprises the mutations X230F, X267G, X294R, X480K, X543D, X1219V, and X1256K of the amino acid sequence provided in SEQ ID NO: 9, or corresponding mutations in any of the amino acid sequences provided in SEQ ID NOs: 10-262, wherein X represents any amino acid.

223. The Cas9 protein of any of claims 218-221, wherein the amino acid sequence of the Cas9 protein comprises the mutations X294R, X480K, X543D, X711E, X1207G, X1219V, and X1256K of the amino acid sequence provided in SEQ ID NO: 9, or corresponding mutations in any of the amino acid sequences provided in SEQ ID NOs: 10-262, wherein X represents any amino acid.

224. The Cas9 protein of any of claims 218-221, wherein the amino acid sequence of the Cas9 protein comprises the mutations X175T, X267G, X294R, X480K, X543D, X1219V, and X1256K of the amino acid sequence provided in SEQ ID NO: 9, or corresponding mutations in any of the amino acid sequences provided in SEQ ID NOs: 10-262, wherein X represents any amino acid.

225. The Cas9 protein of any of claims 218-221, wherein the amino acid sequence of the Cas9 protein comprises the mutations X257N, X267G, X294R, X466A, X480K, X543D, X1063V, X1219V, and X1256K of the amino acid sequence provided in SEQ ID NO: 9, or corresponding mutations in any of the amino acid sequences provided in SEQ ID NOs: 10- 262, wherein X represents any amino acid.

226. The Cas9 protein of any of claims 218-221, wherein the amino acid sequence of the Cas9 protein comprises the mutations X294R, X480K, X543D, X1219V, and X1256K of the amino acid sequence provided in SEQ ID NO: 9, or corresponding mutations in any of the amino acid sequences provided in SEQ ID NOs: 10-262, wherein X represents any amino acid.

227. The Cas9 protein of any of claims 218-221, wherein the amino acid sequence of the Cas9 protein comprises the mutations X294R, and X1256K of the amino acid sequence provided in SEQ ID NO: 9, or corresponding mutations in any of the amino acid sequences provided in SEQ ID NOs: 10-262, wherein X represents any amino acid.

228. The Cas9 protein of any of claims 218-221, wherein the amino acid sequence of the Cas9 protein comprises the mutations P230F, S267G, K294R, E480K, E543D, E1219V, and Q1256K of the amino acid sequence provided in SEQ ID NO: 9, or corresponding mutations in any of the amino acid sequences provided in SEQ ID NOs: 10-262.

229. The Cas9 protein of any of claims 218-221, wherein the amino acid sequence of the Cas9 protein comprises the mutations K294R, E480K, E543D, A71 IE, E1207G, E1219V, and Q1256K of the amino acid sequence provided in SEQ ID NO: 9, or corresponding mutations in any of the amino acid sequences provided in SEQ ID NOs: 10-262.

230. The Cas9 protein of any of claims 218-221, wherein the amino acid sequence of the Cas9 protein comprises the mutations N175T, S267G, K294R, E480K, E543D, E1219V, and Q1256K of the amino acid sequence provided in SEQ ID NO: 9, or corresponding mutations in any of the amino acid sequences provided in SEQ ID NOs: 10-262.

231. The Cas9 protein of any of claims 218-221, wherein the amino acid sequence of the Cas9 protein comprises the mutations D257N, S267G, K294R, T466A, E480K, E543D, I1063V, E1219V, and Q1256K of the amino acid sequence provided in SEQ ID NO: 9, or corresponding mutations in any of the amino acid sequences provided in SEQ ID NOs: 10- 262.

232. The Cas9 protein of any of claims 218-221, wherein the amino acid sequence of the Cas9 protein comprises the mutations K294R, E480K, E543D, E1219V, and Q1256K of the amino acid sequence provided in SEQ ID NO: 9, or corresponding mutations in any of the amino acid sequences provided in SEQ ID NOs: 10-262.

233. The Cas9 protein of any of claims 218-221, wherein the amino acid sequence of the Cas9 protein comprises the mutations K294R, and Q1256K of the amino acid sequence provided in SEQ ID NO: 9, or corresponding mutations in any of the amino acid sequences provided in SEQ ID NOs: 10-262.

234. The Cas9 protein of any one of claims 218-233, wherein the amino acid sequence of the HNH domain is at least 80%, at least 85%, at least 90%, at least 92%, at least 95%, at least 96%), at least 97%, at least 98%>, at least 99%, or at least 99.5% identical to the amino acid sequence of the HNH domain of any of SEQ ID NOs: 9-262.

235. The Cas9 protein of any one of claims 219-234, wherein the amino acid sequence of the HNH domain is identical to the amino acid sequence of the HNH domain of SEQ ID NO: 9.

236. The Cas9 protein of any one of claims 219-235, wherein the amino acid sequence of the RuvC domain is at least 80%, at least 85%, at least 90%, at least 92%, at least 95%, at least 96%), at least 97%, at least 98%, at least 99%, or at least 99.5% identical to the amino acid sequence of the RuvC domain of any of SEQ ID NOs: 9-262.

237. The Cas9 protein of any one of claims 219-236, wherein the amino acid sequence of the RuvC domain is identical to the amino acid sequence of the RuvC domain of SEQ ID NO: 9.

238. The Cas9 protein of any one of claims 218-237, wherein the Cas9 protein comprises a D10A and/or a H840A mutation of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10- 262.

239. The Cas9 protein of any one of claims 218-238, wherein the Cas9 protein comprises a DIOXi and/or a H840X₂ mutation of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10- 262, wherein Xi is any amino acid except for D and wherein X₂ is any amino acid except for H.

240. The Cas9 protein of any one of claims 218-239, wherein the Cas9 protein comprises an D10A mutation of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262.

241. The Cas9 protein of claim 240, wherein the Cas9 protein comprises an H at amino acid residue 840 of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding residue in any of the amino acid sequences provided in SEQ ID NOs: 10-262.

242. The Cas9 protein of any one of claims 218-240, wherein the Cas9 protein comprises an H840A mutation of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262.

243. The Cas9 protein of claim 242, wherein the Cas9 protein comprises an D at amino acid residue 10 of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding residue in any of the amino acid sequences provided in SEQ ID NOs: 10-262.

244. The Cas9 protein of any one of claims 218-243, wherein the Cas9 protein exhibits an increased activity on a target sequence that does not comprise the canonical PAM (5 '-NOGS ') at its 3' end as compared to Streptococcus pyogenes Cas9 as provided by SEQ ID NO: 9.

245. A recombinant Cas9 protein comprising an amino acid sequence that is at least 90% identical to the amino acid sequence of Streptococcus pyogenes Cas9 as provided by SEQ ID NO: 9, or to a fragment thereof,

wherein the amino acid sequence of the Cas9 protein comprises at least one, at least two, at least three, at least four, at least five, at least six, or at least seven mutations in an amino acid residue selected from the group consisting of amino acid residues 175, 230, 257, 267, 294, 466, 480, 543, 711, 1063, 1207, 1219, and 1256 of the amino acid sequence provided in SEQ ID NO: 9,

wherein the amino acid sequence of the recombinant Cas9 protein is not identical to the amino acid sequence of a naturally occurring Cas9 protein, and

wherein the recombinant Cas9 protein exhibits an increased activity on a target sequence that does not comprise the canonical PAM (5'-NGG-3') at its 3' end as compared to Streptococcus pyogenes Cas9 as provided by SEQ ID NO: 9.

246. The Cas9 protein of claim 245, wherein the Cas9 protein comprises a RuvC and an HNH domain.

247. The Cas9 protein of claim 245 or 246, wherein the Cas9 protein exhibits an activity on a target sequence having a 3' end that is not directly adjacent to the canonical PAM sequence (5'-NGG-3 ') that is at least 5-fold, at least 10-fold, at least 50-fold, at least 100-fold, at least 500-fold, at least 1,000-fold, at least 5,000-fold, at least 10,000-fold, at least 50,000-fold, at least 100,000-fold, at least 500,000-fold, or at least 1,000,000-fold increased as compared to the activity of Streptococcus pyogenes Cas9 as provided by SEQ ID NO: 9 on the same target sequence.

248. The Cas9 protein of claim 247, wherein the 3' end of the target sequence is directly adjacent to an AGC, GAG, TTT, GTG, or CAA sequence.

249. The Cas9 protein of claim 247 or 248, wherein the 3' end of the target sequence is directly adjacent to a sequence selected from the group consisting of CAC, GAT, TAA, ACG, CGA, and CGT.

250. The Cas9 protein of any one of claims 246-249, wherein the Cas9 protein activity is measured by a nuclease assay, a deamination assay, or a transcriptional activation assay.

251. The Cas9 protein of claim 250, wherein the transcriptional activation assay is a GFP activation assay.

252. The Cas9 protein of any one of claims 245-251, wherein the amino acid sequence of the Cas9 protein comprises at least one, at least two, at least three, at least four, at least five, at least six, at least seven, at least eight, or at least nine mutations selected from the group consisting of X175T, X230F, X257N, X267G, X294R, X466A, X480K, X543D, X711E, X1207G, X1063V, X1219V, and X1256K of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262, wherein X represents any amino acid.

253. The Cas9 protein of any one of claims 245-252, wherein the amino acid sequence of the Cas9 protein or the fragment thereof comprises at least one, at least two, at least three, at least four, at least five, at least six, at least seven, at least eight, or at least nine mutations selected from the group consisting of N175T, P230F, D257N, S267G, K294R, T466A, E480K, E543D, A711E, E1207G, I1063V, E1219V, and Q1256K of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262.

254. The Cas9 protein of any of claims 245-253, wherein the amino acid sequence of the Cas9 protein or the fragment thereof comprises the mutations X230F, X267G, X294R, X480K, X543D, X1219V, and X1256K of the amino acid sequence provided in SEQ ID NO: 9, or corresponding mutations in any of the amino acid sequences provided in SEQ ID NOs: 10-262, wherein X represents any amino acid.

255. The Cas9 protein of any of claims 245-253, wherein the amino acid sequence of the Cas9 protein or the fragment thereof comprises the mutations X294R, X480K, X543D, X71 IE, X1207G, X1219V, and X1256K of the amino acid sequence provided in SEQ ID NO: 9, or corresponding mutations in any of the amino acid sequences provided in SEQ ID NOs: 10-262, wherein X represents any amino acid.

256. The Cas9 protein of any of claims 245-253, wherein the amino acid sequence of the Cas9 protein or the fragment thereof comprises the mutations X175T, X267G, X294R, X480K, X543D, X1219V, and X1256K of the amino acid sequence provided in SEQ ID NO: 9, or corresponding mutations in any of the amino acid sequences provided in SEQ ID NOs: 10-262, wherein X represents any amino acid.

257. The Cas9 protein of any of claims 245-253, wherein the amino acid sequence of the Cas9 protein or the fragment thereof comprises the mutations X257N, X267G, X294R, X466A, X480K, X543D, X1063V, X1219V, and X1256K of the amino acid sequence provided in SEQ ID NO: 9, or corresponding mutations in any of the amino acid sequences provided in SEQ ID NOs: 10-262, wherein X represents any amino acid.

258. The Cas9 protein of any of claims 245-253, wherein the amino acid sequence of the Cas9 protein or the fragment thereof comprises the mutations X294R, X480K, X543D, X1219V, and X1256K of the amino acid sequence provided in SEQ ID NO: 9, or corresponding mutations in any of the amino acid sequences provided in SEQ ID NOs: 10- 262, wherein X represents any amino acid.

259. The Cas9 protein of any of claims 245-253, wherein the amino acid sequence of the Cas9 protein or the fragment thereof comprises the mutations X294R, and X1256K of the amino acid sequence provided in SEQ ID NO: 9, or corresponding mutations in any of the amino acid sequences provided in SEQ ID NOs: 10-262, wherein X represents any amino acid.

260. The Cas9 protein of any of claims 245-253, wherein the amino acid sequence of the Cas9 protein or the fragment thereof comprises the mutations P230F, S267G, K294R, E480K, E543D, E1219V, and Q1256K of the amino acid sequence provided in SEQ ID NO: 9, or corresponding mutations in any of the amino acid sequences provided in SEQ ID NOs: 10-262.

261. The Cas9 protein of any of claims 245-253, wherein the amino acid sequence of the Cas9 protein or the fragment thereof comprises the mutations K294R, E480K, E543D,

A71 IE, E1207G, E1219V, and Q1256K of the amino acid sequence provided in SEQ ID NO: 9, or corresponding mutations in any of the amino acid sequences provided in SEQ ID NOs: 10-262.

262. The Cas9 protein of any of claims 245-253, wherein the amino acid sequence of the Cas9 protein or the fragment thereof comprises the mutations N175T, S267G, K294R, E480K, E543D, E1219V, and Q1256K of the amino acid sequence provided in SEQ ID NO: 9, or corresponding mutations in any of the amino acid sequences provided in SEQ ID NOs: 10-262.

263. The Cas9 protein of any of claims 245-253, wherein the amino acid sequence of the Cas9 protein or the fragment thereof comprises the mutations D257N, S267G, K294R, T466A, E480K, E543D, I1063V, E1219V, and Q1256K of the amino acid sequence provided in SEQ ID NO: 9, or corresponding mutations in any of the amino acid sequences provided in SEQ ID NOs: 10-262.

264. The Cas9 protein of any of claims 245-253, wherein the amino acid sequence of the Cas9 protein or the fragment thereof comprises the mutations K294R, E480K, E543D, E1219V, and Q1256K of the amino acid sequence provided in SEQ ID NO: 9, or

corresponding mutations in any of the amino acid sequences provided in SEQ ID NOs: 10- 262.

265. The Cas9 protein of any of claims 245-253, wherein the amino acid sequence of the Cas9 protein or the fragment thereof comprises the mutations K294R, and Q1256K of the amino acid sequence provided in SEQ ID NO: 9, or corresponding mutations in any of the amino acid sequences provided in SEQ ID NOs: 10-262.

266. The Cas9 protein of any one of claims 246-265, wherein the amino acid sequence of the HNH domain is at least 80%, at least 85%, at least 90%, at least 92%, at least 95%, at least 96%), at least 97%, at least 98%>, at least 99%, or at least 99.5% identical to the amino acid sequence of the HNH domain of any of SEQ ID NOs: 9-262.

267. The Cas9 protein of any one of claims 246-266, wherein the amino acid sequence of the HNH domain is identical to the amino acid sequence of the HNH domain of SEQ ID NO: 9.

268. The Cas9 protein of any one of claims 246-267, wherein the amino acid sequence of the RuvC domain is at least 80%, at least 85%, at least 90%, at least 92%, at least 95%, at least 96%), at least 97%, at least 98%, at least 99%, or at least 99.5% identical to the amino acid sequence of the RuvC domain of any of SEQ ID NOs: 9-262.

269. The Cas9 protein of any one of claims 247-268, wherein the amino acid sequence of the RuvC domain is identical to the amino acid sequence of the RuvC domain of SEQ ID NO: 9.

270. The Cas9 protein of any one of claims 245-269, wherein the Cas9 protein or the fragment thereof comprises at D10A and/or a H840A mutation in the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262.

271. The Cas9 protein of any one of claims 245-269, wherein the Cas9 protein or the fragment thereof comprises a D10X₁ and/or a H840X₂ mutation of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262, wherein Xi is any amino acid except for D and wherein X₂ is any amino acid except for H.

272. The Cas9 protein of any one of claims 245-271, wherein the Cas9 protein or the fragment thereof comprises an DIOA mutation of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262.

273. The Cas9 protein of claim 272, wherein the Cas9 protein or the fragment thereof comprises an H at amino acid residue 840 of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding residue in any of the amino acid sequences provided in SEQ ID NOs: 10-262.

274. The Cas9 protein of any one of claims 245-272, wherein the Cas9 protein or the fragment thereof comprises an H840A mutation of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262.

275. The Cas9 protein of claim 274, wherein the Cas9 protein or the fragment thereof comprises an D at amino acid residue 10 of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding residue in any of the amino acid sequences provided in SEQ ID NOs: 10-262.

276. A recombinant Cas9 protein comprising an amino acid sequence that is at least 80%, at least 85%, at least 90%, at least 92%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%), or at least 99.5% identical to the amino acid sequence of a Cas9 as provided by any one of SEQ ID NOs: 9-262,

wherein the amino acid sequence of the Cas9 protein comprises at least one, at least two, at least three, at least four, at least five, at least six, or at least seven mutations in an amino acid residue selected from the group consisting of amino acid residues 108, 217, 262, 324, 409, 480, 543, 673, 694, 1219, 1264, and 1365 of the amino acid sequence provided in SEQ ID NO: 9, or in a corresponding amino acid residue in any of the amino acid sequences provided in SEQ ID NOs: 10-262, and wherein the amino acid sequence of the recombinant Cas9 protein is not identical to the amino acid sequence of a naturally occurring Cas9 protein.

277. The Cas9 protein of claim 276, wherein the Cas9 protein comprises a RuvC and an HNH domain.

278. The Cas9 protein of claim 276 or 277, wherein the amino acid sequence of the Cas9 protein comprises at least one, at least two, at least three, at least four, at least five, at least six, at least seven, at least eight, or at least nine mutations selected from the group consisting of X108G, X217A, X262T, X324L, X409I, X480K, X543D, X673E, X694I, X1219V, X1264Y, and X1365I of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10- 262, wherein X represents any amino acid.

279. The Cas9 protein of any one of claims 276-278, wherein the amino acid sequence of the Cas9 protein comprises at least one, at least two, at least three, at least four, at least five, at least six, at least seven, at lest eight, or at least nine mutations selected from the group consisting of E108G, S217A, A262T, R324L, S409I, E480K, E543D, K673E, M694I, E1219V, H1264Y, and L1365I of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10- 262.

280. The Cas9 protein of any of claims 276-279, wherein the amino acid sequence of the Cas9 protein comprises the mutations X108G, X262T, X409I, X480K, X543D, X673E, X694I, X1219V, and X1365I of the amino acid sequence provided in SEQ ID NO: 9, or corresponding mutations in any of the amino acid sequences provided in SEQ ID NOs: 10- 262, wherein X represents any amino acid.

281. The Cas9 protein of any of claims 276-279, wherein the amino acid sequence of the Cas9 protein comprises the mutations X108G, X217A, X262T, X409I, X480K, X543D, X694I, X1219V, and X1365I of the amino acid sequence provided in SEQ ID NO: 9, or corresponding mutations in any of the amino acid sequences provided in SEQ ID NOs: 10- 262, wherein X represents any amino acid.

281. The Cas9 protein of any of claims 276-279, wherein the amino acid sequence of the Cas9 protein comprises the mutations X262T, X324L, X409I, X480K, X543D, X694I, and X1219V of the amino acid sequence provided in SEQ ID NO: 9, or corresponding mutations in any of the amino acid sequences provided in SEQ ID NOs: 10-262, wherein X represents any amino acid.

283. The Cas9 protein of any of claims 276-279, wherein the amino acid sequence of the Cas9 protein comprises the mutations X262T, X409I, X480K, X543D, X694I, X1219V, and X1264Y of the amino acid sequence provided in SEQ ID NO: 9, or corresponding mutations in any of the amino acid sequences provided in SEQ ID NOs: 10-262, wherein X represents any amino acid.

284. The Cas9 protein of any of claims 276-279, wherein the amino acid sequence of the Cas9 protein comprises the mutations X262T, X409I, X480K, X543D, X694I, and X1219V of the amino acid sequence provided in SEQ ID NO: 9, or corresponding mutations in any of the amino acid sequences provided in SEQ ID NOs: 10-262, wherein X represents any amino acid.

285. The Cas9 protein of any of claims 276-279, wherein the amino acid sequence of the Cas9 protein comprises the mutations X262T, X409I, X480K, X543D, X694I, X1219V, and X1365I of the amino acid sequence provided in SEQ ID NO: 9, or corresponding mutations in any of the amino acid sequences provided in SEQ ID NOs: 10-262, wherein X represents any amino acid.

286. The Cas9 protein of any of claims 276-279, wherein the amino acid sequence of the Cas9 protein comprises the mutations X108G, X262T, X409I, X480K, X543D, X673E, X694I, and X1219V of the amino acid sequence provided in SEQ ID NO: 9, or

corresponding mutations in any of the amino acid sequences provided in SEQ ID NOs: 10- 262, wherein X represents any amino acid.

287. The Cas9 protein of any of claims 276-279, wherein the amino acid sequence of the Cas9 protein comprises the mutations X108G, X262T, X409I, X480K, X543D, X694I, X1219V, and X1365I of the amino acid sequence provided in SEQ ID NO: 9, or corresponding mutations in any of the amino acid sequences provided in SEQ ID NOs: 10- 262, wherein X represents any amino acid.

288. The Cas9 protein of any of claims 276-279, wherein the amino acid sequence of the Cas9 protein comprises the mutations X262T, and X409I of the amino acid sequence provided in SEQ ID NO: 9, or corresponding mutations in any of the amino acid sequences provided in SEQ ID NOs: 10-262, wherein X represents any amino acid.

289. The Cas9 protein of any of claims 276-279, wherein the amino acid sequence of the Cas9 protein comprises the mutations E108G, A262T, S409I, E480K, E543D, K673E, M694I, E1219V, and LI 3651 of the amino acid sequence provided in SEQ ID NO: 9, or corresponding mutations in any of the amino acid sequences provided in SEQ ID NOs: 10- 262.

290. The Cas9 protein of any of claims 276-279, wherein the amino acid sequence of the Cas9 protein comprises the mutations E108G, S217A, A262T, S409I, E480K, E543D, M694I, E1219V, and LI 365 of the amino acid sequence provided in SEQ ID NO: 9, or corresponding mutations in any of the amino acid sequences provided in SEQ ID NOs: 10- 262.

291. The Cas9 protein of any of claims 276-279, wherein the amino acid sequence of the Cas9 protein comprises the mutations A262T, R324L, S409I, E480K, E543D, M694I, and E1219V of the amino acid sequence provided in SEQ ID NO: 9, or corresponding mutations in any of the amino acid sequences provided in SEQ ID NOs: 10-262.

292. The Cas9 protein of any of claims 276-279, wherein the amino acid sequence of the Cas9 protein comprises the mutations A262T, S409I, E480K, E543D, M694I, E1219V, and H1264Y of the amino acid sequence provided in SEQ ID NO: 9, or corresponding mutations in any of the amino acid sequences provided in SEQ ID NOs: 10-262.

293. The Cas9 protein of any of claims 276-279, wherein the amino acid sequence of the Cas9 protein comprises the mutations A262T, S409I, E480K, E543D, M694I, and E1219V of the amino acid sequence provided in SEQ ID NO: 9, or corresponding mutations in any of the amino acid sequences provided in SEQ ID NOs: 10-262.

294. The Cas9 protein of any of claims 276-279, wherein the amino acid sequence of the Cas9 protein comprises the mutations A262T, S409I, E480K, E543D, M694I, E1219V, and L1365I of the amino acid sequence provided in SEQ ID NO: 9, or corresponding mutations in any of the amino acid sequences provided in SEQ ID NOs: 10-262.

295. The Cas9 protein of any of claims 276-279, wherein the amino acid sequence of the Cas9 protein comprises the mutations E108G, A262T, S409I, E480K, E543D, K673E, M694I, and E1219V of the amino acid sequence provided in SEQ ID NO: 9, or

corresponding mutations in any of the amino acid sequences provided in SEQ ID NOs: 10- 262.

296. The Cas9 protein of any of claims 276-279, wherein the amino acid sequence of the Cas9 protein comprises the mutations E108G, A262T, S409I, E480K, E543D, M694I, E1219V, and LI 3651 of the amino acid sequence provided in SEQ ID NO: 9, or

corresponding mutations in any of the amino acid sequences provided in SEQ ID NOs: 10- 262.

297. The Cas9 protein of any of claims 276-279, wherein the amino acid sequence of the Cas9 protein comprises the mutations A262T, and S409I of the amino acid sequence provided in SEQ ID NO: 9, or corresponding mutations in any of the amino acid sequences provided in SEQ ID NOs: 10-262.

298. The Cas9 protein of any one of claims 276-297, wherein the amino acid sequence of the HNH domain is at least 80%, at least 85%, at least 90%, at least 92%, at least 95%, at least 96%), at least 97%, at least 98%>, at least 99%, or at least 99.5% identical to the amino acid sequence of the HNH domain of any of SEQ ID NOs: 9-262.

299. The Cas9 protein of any one of claims 277-298, wherein the amino acid sequence of the HNH domain is identical to the amino acid sequence of the HNH domain of SEQ ID NO: 9.

300. The Cas9 protein of any one of claims 277-299, wherein the amino acid sequence of the RuvC domain is at least 80%, at least 85%, at least 90%, at least 92%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or at least 99.5% identical to the amino acid sequence of the RuvC domain of any of SEQ ID NOs: 9-262.

301. The Cas9 protein of any one of claims 277-300, wherein the amino acid sequence of the RuvC domain is identical to the amino acid sequence of the RuvC domain of SEQ ID NO: 9.

302. The Cas9 protein of any one of claims 276-301, wherein the Cas9 protein comprises a DIOA and/or a H840A mutation of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10- 262.

303. The Cas9 protein of any one of claims 276-302, wherein the Cas9 protein comprises a DIOXi and/or a H840X₂ mutation of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10- 262, wherein X₁ is any amino acid except for D and wherein X₂ is any amino acid except for H.

304. The Cas9 protein of any one of claims 276-303, wherein the Cas9 protein comprises an DIOA mutation of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262.

305. The Cas9 protein of claim 304, wherein the Cas9 protein comprises an H at amino acid residue 840 of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding residue in any of the amino acid sequences provided in SEQ ID NOs: 10-262.

306. The Cas9 protein of any one of claims 276-304, wherein the Cas9 protein comprises an H840A mutation of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262.

307. The Cas9 protein of claim 306, wherein the Cas9 protein comprises an D at amino acid residue 10 of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding residue in any of the amino acid sequences provided in SEQ ID NOs: 10-262.

308. The Cas9 protein of any one of claims 276-307, wherein the Cas9 protein exhibits an increased activity on a target sequence that does not comprise the canonical PAM (5 '-NOGS ') at its 3' end as compared to Streptococcus pyogenes Cas9 as provided by SEQ ID NO: 9.

309. A recombinant Cas9 protein comprising an amino acid sequence that is at least 90% identical to the amino acid sequence of Streptococcus pyogenes Cas9 as provided by SEQ ID NO: 9, or to a fragment thereof,

wherein the amino acid sequence of the Cas9 protein comprises at least one, at least two, at least three, at least four, at least five, at least six, or at least seven mutations in an amino acid residue selected from the group consisting of amino acid residues 108, 217, 262, 324, 409, 480, 543, 673, 694, 1219, 1264, and 1365 of the amino acid sequence provided in SEQ ID NO: 9,

wherein the amino acid sequence of the recombinant Cas9 protein is not identical to the amino acid sequence of a naturally occurring Cas9 protein, and

wherein the recombinant Cas9 protein exhibits an increased activity on a target sequence that does not comprise the canonical PAM (5'-NGG-3') at its 3' end as compared to Streptococcus pyogenes Cas9 as provided by SEQ ID NO: 9.

310. The Cas9 protein of claim 309, wherein the Cas9 protein comprises a RuvC and an HNH domain.

311. The Cas9 protein of claim 309 or 310, wherein the Cas9 protein exhibits an activity on a target sequence having a 3' end that is not directly adjacent to the canonical PAM sequence (5'-NGG-3 ') that is at least 5-fold, at least 10-fold, at least 50-fold, at least 100-fold, at least 500-fold, at least 1,000-fold, at least 5,000-fold, at least 10,000-fold, at least 50,000-fold, at least 100,000-fold, at least 500,000-fold, or at least 1,000,000-fold increased as compared to the activity of Streptococcus pyogenes Cas9 as provided by SEQ ID NO: 9 on the same target sequence.

312. The Cas9 protein of claim 311, wherein the 3' end of the target sequence is directly adjacent to an AGC, GAG, TTT, GTG, or CAA sequence.

313. The Cas9 protein of claim 311 or 312, wherein the 3' end of the target sequence is directly adjacent to a sequence selected from the group consisting of CAC, GAT, TAA, ACG, CGA, and CGT.

314. The Cas9 protein of any one of claims 310-313, wherein the Cas9 protein activity is measured by a nuclease assay, a deamination assay, or a transcriptional activation assay.

315. The Cas9 protein of claim 314, wherein the transcriptional activation assay is a GFP activation assay.

316. The Cas9 protein of any one of claims 309-315, wherein the amino acid sequence of the Cas9 protein comprises at least one, at least two, at least three, at least four, at least five, at least six, at least seven, at least eight, or at least nine mutations selected from the group consisting of X108G, X217A, X262T, X324L, X409I, X480K, X543D, X673E, X694I, X1219V, X1264Y, and X1365I of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10- 262, wherein X represents any amino acid.

317. The Cas9 protein of any one of claims 309-316, wherein the amino acid sequence of the Cas9 protein or the fragment thereof comprises at least one, at least two, at least three, at least four, at least five, at least six, at least seven, at least eight, or at least nine mutations selected from the group consisting of E108G, S217A, A262T, R324L, S409I, E480K, E543D, K673E, M694I, E1219V, H1264Y, and L1365I of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262.

318. The Cas9 protein of any of claims 309-317, wherein the amino acid sequence of the Cas9 protein or the fragment thereof comprises the mutations X108G, X262T, X409I, X480K, X543D, X673E, X694I, X1219V, and X1365I of the amino acid sequence provided in SEQ ID NO: 9, or corresponding mutations in any of the amino acid sequences provided in SEQ ID NOs: 10-262, wherein X represents any amino acid.

319. The Cas9 protein of any of claims 309-317, wherein the amino acid sequence of the Cas9 protein or the fragment thereof comprises the mutations X108G, X217A, X262T, X409I, X480K, X543D, X694I, X1219V, and X1365I of the amino acid sequence provided in SEQ ID NO: 9, or corresponding mutations in any of the amino acid sequences provided in SEQ ID NOs: 10-262, wherein X represents any amino acid.

320. The Cas9 protein of any of claims 309-317, wherein the amino acid sequence of the Cas9 protein or the fragment thereof comprises the mutations X262T, X324L, X409I, X480K, X543D, X694I, and X1219V of the amino acid sequence provided in SEQ ID NO: 9, or corresponding mutations in any of the amino acid sequences provided in SEQ ID NOs: 10- 262, wherein X represents any amino acid.

321. The Cas9 protein of any of claims 309-317, wherein the amino acid sequence of the Cas9 protein or the fragment thereof comprises the mutations X262T, X409I, X480K, X543D, X694I, X1219V, and X1264Y of the amino acid sequence provided in SEQ ID NO: 9, or corresponding mutations in any of the amino acid sequences provided in SEQ ID NOs: 10-262, wherein X represents any amino acid.

322. The Cas9 protein of any of claims 309-317, wherein the amino acid sequence of the Cas9 protein or the fragment thereof comprises the mutations X262T, X409I, X480K, X543D, X694I, and X1219V of the amino acid sequence provided in SEQ ID NO: 9, or corresponding mutations in any of the amino acid sequences provided in SEQ ID NOs: 10- 262, wherein X represents any amino acid.

323. The Cas9 protein of any of claims 309-317, wherein the amino acid sequence of the Cas9 protein or the fragment thereof comprises the mutations X262T, X409I, X480K, X543D, X694I, X1219V, and X1365I of the amino acid sequence provided in SEQ ID NO: 9, or corresponding mutations in any of the amino acid sequences provided in SEQ ID NOs: 10- 262, wherein X represents any amino acid.

234. The Cas9 protein of any of claims 309-317, wherein the amino acid sequence of the Cas9 protein or the fragment thereof comprises the mutations X108G, X262T, X409I, X480K, X543D, X673E, X694I, and X1219V of the amino acid sequence provided in SEQ ID NO: 9, or corresponding mutations in any of the amino acid sequences provided in SEQ ID NOs: 10-262, wherein X represents any amino acid.

235. The Cas9 protein of any of claims 309-317, wherein the amino acid sequence of the Cas9 protein or the fragment thereof comprises the mutations X108G, X262T, X409I, X480K, X543D, X694I, X1219V, and X1365I of the amino acid sequence provided in SEQ ID NO: 9, or corresponding mutations in any of the amino acid sequences provided in SEQ ID NOs: 10-262, wherein X represents any amino acid.

326. The Cas9 protein of any of claims 309-317, wherein the amino acid sequence of the Cas9 protein or the fragment thereof comprises the mutations X262T, and X409I of the amino acid sequence provided in SEQ ID NO: 9, or corresponding mutations in any of the amino acid sequences provided in SEQ ID NOs: 10-262, wherein X represents any amino acid.

327. The Cas9 protein of any of claims 309-317, wherein the amino acid sequence of the Cas9 protein or the fragment thereof comprises the mutations E108G, A262T, S409I, E480K, E543D, K673E, M694I, E1219V, and LI 3651 of the amino acid sequence provided in SEQ ID NO: 9, or corresponding mutations in any of the amino acid sequences provided in SEQ ID NOs: 10-262.

328. The Cas9 protein of any of claims 309-317, wherein the amino acid sequence of the Cas9 protein or the fragment thereof comprises the mutations E108G, S217A, A262T, S409I, E480K, E543D, M694I, E1219V, and LI 3651 of the amino acid sequence provided in SEQ ID NO: 9, or corresponding mutations in any of the amino acid sequences provided in SEQ ID NOs: 10-262.

329. The Cas9 protein of any of claims 309-317, wherein the amino acid sequence of the Cas9 protein or the fragment thereof comprises the mutations A262T, R324L, S409I, E480K, E543D, M694I, and E1219V of the amino acid sequence provided in SEQ ID NO: 9, or corresponding mutations in any of the amino acid sequences provided in SEQ ID NOs: 10- 262.

330. The Cas9 protein of any of claims 309-317, wherein the amino acid sequence of the Cas9 protein or the fragment thereof comprises the mutations A262T, S409I, E480K, E543D, M694I, E1219V, and H1264Y of the amino acid sequence provided in SEQ ID NO: 9, or corresponding mutations in any of the amino acid sequences provided in SEQ ID NOs: 10- 262.

331. The Cas9 protein of any of claims 309-317, wherein the amino acid sequence of the Cas9 protein or the fragment thereof comprises the mutations A262T, S409I, E480K, E543D, M694I, and E1219V of the amino acid sequence provided in SEQ ID NO: 9, or

corresponding mutations in any of the amino acid sequences provided in SEQ ID NOs: 10- 262.

332. The Cas9 protein of any of claims 309-317, wherein the amino acid sequence of the Cas9 protein or the fragment thereof comprises the mutations A262T, S409I, E480K, E543D, M694I, E1219V, and LI 3651 of the amino acid sequence provided in SEQ ID NO: 9, or corresponding mutations in any of the amino acid sequences provided in SEQ ID NOs: 10- 262.

333. The Cas9 protein of any of claims 309-317, wherein the amino acid sequence of the Cas9 protein or the fragment thereof comprises the mutations E108G, A262T, S409I, E480K, E543D, K673E, M694I, and E1219V of the amino acid sequence provided in SEQ ID NO: 9, or corresponding mutations in any of the amino acid sequences provided in SEQ ID NOs: 10- 262.

334. The Cas9 protein of any of claims 309-317, wherein the amino acid sequence of the Cas9 protein or the fragment thereof comprises the mutations E108G, A262T, S409I, E480K, E543D, M694I, E1219V, and L1365I of the amino acid sequence provided in SEQ ID NO: 9, or corresponding mutations in any of the amino acid sequences provided in SEQ ID NOs: 10- 262.

335. The Cas9 protein of any of claims 309-317, wherein the amino acid sequence of the Cas9 protein or the fragment thereof comprises the mutations A262T, and S409I of the amino acid sequence provided in SEQ ID NO: 9, or corresponding mutations in any of the amino acid sequences provided in SEQ ID NOs: 10-262.

336. The Cas9 protein of any one of claims 310-335, wherein the amino acid sequence of the HNH domain is at least 80%, at least 85%, at least 90%, at least 92%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or at least 99.5% identical to the amino acid sequence of the HNH domain of any of SEQ ID NOs: 9-262.

337. The Cas9 protein of any one of claims 310-330, wherein the amino acid sequence of the HNH domain is identical to the amino acid sequence of the HNH domain of SEQ ID NO: 9.

338. The Cas9 protein of any one of claims 310-337, wherein the amino acid sequence of the RuvC domain is at least 80%, at least 85%, at least 90%, at least 92%, at least 95%, at least 96%), at least 97%, at least 98%, at least 99%, or at least 99.5% identical to the amino acid sequence of the RuvC domain of any of SEQ ID NOs: 9-262.

339. The Cas9 protein of any one of claims 310-338, wherein the amino acid sequence of the RuvC domain is identical to the amino acid sequence of the RuvC domain of SEQ ID NO: 9.

340. The Cas9 protein of any one of claims 309-339, wherein the Cas9 protein or the fragment thereof comprises at D10A and/or a H840A mutation in the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262.

341. The Cas9 protein of any one of claims 309-339, wherein the Cas9 protein or the fragment thereof comprises a D10X₁ and/or a H840X₂ mutation of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262, wherein X₁ is any amino acid except for D and wherein X₂ is any amino acid except for H.

342. The Cas9 protein of any one of claims 309-341, wherein the Cas9 protein or the fragment thereof comprises an D10A mutation of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262.

343. The Cas9 protein of claim 342, wherein the Cas9 protein or the fragment thereof comprises an H at amino acid residue 840 of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding residue in any of the amino acid sequences provided in SEQ ID NOs: 10-262.

344. The Cas9 protein of any one of claims 309-342, wherein the Cas9 protein or the fragment thereof comprises an H840A mutation of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding mutation in any of the amino acid sequences provided in SEQ ID NOs: 10-262.

345. The Cas9 protein of claim 344, wherein the Cas9 protein or the fragment thereof comprises an D at amino acid residue 10 of the amino acid sequence provided in SEQ ID NO: 9, or a corresponding residue in any of the amino acid sequences provided in SEQ ID NOs: 10-262.

346. A fusion protein comprising the Cas9 protein of any one of claims 1-345, wherein the Cas9 protein or fragment is fused to an effector domain, thus forming a fusion protein.

347. The fusion protein of claim 346, wherein the effector domain is fused to the N-terminus of the Cas9 protein.

348. The fusion protein of claim 346, wherein the effector domain is fused to the C-terminus of the Cas9 protein.

349. The fusion protein of any one of claims 346-348, wherein the Cas9 protein and the effector domain are fused via a linker.

350 The fusion protein of any one of claims 346-349, wherein the effector dimain is a nucleic acid editing-domain.

351. The fusion protein of claim 349 or 350, wherein the linker comprises a (GGGGS)_n (SEQ ID NO: 5), a (G)„, an (EAAAK)_n (SEQ ID NO: 6), a (GGS)„, an

SGSETPGTSESATPES (SEQ ID NO: 7), or an (XP)_n motif, or a combination of any of these, wherein n is independently an integer between 1 and 30.

352. The fusion protein of any one of claims 349-351, wherein the linker comprises a (GGS)₃ motif.

353. The fusion protein of any one of claims 346-352, wherein the effector domain comprises an enzyme domain.

354. The fusion protein of any one of claims 346-353, wherein the effector domain comprises a nuclease domain, a nickase domain, a recombinase domain, a deaminase domain, a methyltransferase domain, a methylase domain, an acetylase domain, an acetyltransferase domain, a transcriptional activator domain, or a transcriptional repressor domain.

355. The fusion protein of claim 354, wherein the effector domain is a domain that comprises nuclease activity, nickase activity, recombinase activity, deaminase activity, methyltransferase activity, methylase activity, acetylase activity, acetyltransferase activity, transcriptional activation activity, or transcriptional repression activity.

356. The fusion protein of claim 350, wherein the effector domain is a deaminase domain.

357. The fusion protein of claim 356, wherein the deaminase is a cytosine deaminase or a cytidine deaminase.

358. The fusion protein of claim 357, wherein the deaminase is an apolipoprotein B mRNA- editing complex (APOBEC) family deaminase.

359. The fusion protein of claim 357, wherein the deaminase is an APOBEC 1 deaminase.

360. The fusion protein of claim 357, wherein the deaminase is an APOBEC2 deaminase.

361. The fusion protein of claim 357, wherein the deaminase is an APOBEC3 deaminase.

362. The fusion protein of claim 357, wherein the deaminase is an APOBEC3A deaminase.

363. The fusion protein of claim 357, wherein the deaminase is an APOBEC3D deaminase.

364. The fusion protein of claim 357, wherein the deaminase is an APOBEC3E deaminase.

365. The fusion protein of claim 357, wherein the deaminase is an APOBEC3F deaminase.

366. The fusion protein of claim 357, wherein the deaminase is an APOBEC3G deaminase.

367. The fusion protein of claim 357, wherein the deaminase is an APOBEC3H deaminase.

368. The fusion protein of claim 357, wherein the deaminase is an APOBEC4 deaminase.

369. The fusion protein of claim 357, wherein the deaminase is an activation-induced deaminase (AID).

370. The fusion protein of any one of claims 350-369, wherein the effector domain is at least 80%, at least 85%, at least 90%, at least 92%, at least 95%, at least 96%, at least 97%, at least 98%), at least 99%, or at least 99.5% identical to the deaminase domain of any one of SEQ ID NOs: 263-281.

371. The fusion protein of claim 353, wherein the enzyme domain is a nuclease domain.

372. The fusion protein of claim 371, wherein the nuclease domain is a Fokl DNA cleavage domain.

373. A dimer of the fusion protein of claim 371 or 372.

374. The fusion protein of any one of claims 346-373, wherein the fusion protein is fused to a second Cas9 protein.

375. The fusion protein of claim 374, wherein the second Cas9 protein is Cas9.

376. The fusion protein of claim 374 or 375, wherein the second Cas9 protein is the Cas9 protein of any one of claims 1-345.

377. The fusion protein of claim 374 or 376, wherein the second Cas9 protein is fused to the N-terminus of the fusion protein.

378. The fusion protein of claim 374 or 376, wherein the second Cas9 protein is fused to the C-terminus of the fusion protein.

379. The fusion protein of any one of claims 375-378, wherein the Cas9 protein and the second Cas9 protein are fused via a second linker.

380. The fusion protein of claim 379, wherein the second linker comprises a (GGGGS)_n (SEQ ID NO: 5), a (G)„, an (EAAAK)_n (SEQ ID NO: 6), a (GGS)„, an

SGSETPGTSESATPES (SEQ ID NO: 7), or an (XP)_n motif, or a combination of any of these, wherein n is independently an integer between 1 and 30.

381. The fusion protein of claim 379, wherein the second linker comprises a (GGS)₃ motif.

382. A fusion protein comprising the Cas9 protein of any one of claims 22-345 fused to a second Cas9 protein.

383. The fusion protein of claim 382, wherein the second Cas9 protein is the Cas9 protein of any one of claims 22-345.

384. The fusion protein of claim 382, wherein the second Cas9 protein is the fusion protein of any one of claims 346-373.

385. The fusion protein of claim 383 or 384, wherein the second Cas9 protein is fused to the N-terminus of the the Cas9 protein.

386. The fusion protein of claim 383 or 384, wherein the second Cas9 protein is fused to the C-terminus of the Cas9 protein.

387. The fusion protein of any one of claims 382-386, wherein the second Cas9 protein and the Cas9 protein are fused via a linker.

388. The fusion protein of claim 387, wherein the linker comprises a (GGGGS)_n(SEQ ID NO: 5), a (G)_n, an (EAAAK)_n (SEQ ID NO: 6), a (GGS)_n, an SGSETPGTSESATPES (SEQ ID NO: 7), or an (XP)_n motif, or a combination of any of these, wherein n is independently an integer between 1 and 30.

389. The fusion protein of claim 387, wherein the linker comprises a (GGS)₃ motif.

390. The fusion protein of claim 387, wherein the linker is an SGSETPGTSESATPES (SEQ ID NO: 7) sequence.

391. A complex comprising the Cas9 protein of any one of claims 22-345 or the fusion protein of any one of claims 346-390, and a guide RNA bound to the Cas9 protein or the Cas9 fusion protein.

392. The complex of claim 391, wherein the guide RNA is about 15-100 nucleotides long and comprises a sequence of at least 10 contiguous nucleotides that is complementary to a target sequence.

393. The complex of claim 392, wherein the guide RNA is 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, or 50 nucleotides long.

394. The complex of any one of claims 391-393, wherein the guide RNA comprises a sequence of 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, or 40 contiguous nucleotides that is complementary to a target sequence.

395. The complex of any one of claims 391-394, wherein the target sequence is a DNA sequence.

396. The complex of claim 395, wherein the target sequence is a sequence in the genome of a mammal.

397. The complex of claim 396, wherein the target sequence is a sequence in the genome of a human.

398. The complex of any one of claims 392-397, wherein the 3' end of the target sequence is not immediately adjacent to the canonical PAM sequence (5'-NGG-3 ').

399. A complex comprising the fusion protein of any one of claims 374-390,

a first guide RNA bound to the Cas9 protein of the fusion protein, and

a second guide RNA bound to the second Cas9 protein of the fusion protein.

400. The complex of claim 399, wherein the first guide RNA is about 15-100 nucleotides long and comprises a sequence of at least 10 contiguous nucleotides that is complementary to a first target sequence and the second guide RNA is about 15-100 nucleotides long and comprises a sequence of at least 10 contiguous nucleotides that is complementary to a second target sequence.

401. The complex of claim 400, wherein the first guide RNA and/or the second guide RNA is 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, or 50 nucleotides long.

402. The complex of any one of claims 399-401, wherein the first guide RNA and the second guide RNA are different.

403. The complex of any one of claims 399-402, wherein the first guide RNA comprises a sequence of 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, or 40 contiguous nucleotides that is complementary to a first target sequence and wherein the second guide RNA comprises a sequence of 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, or 40 contiguous nucleotides that is complementary to a second target sequence.

404. The complex of any one of claims 400-403, wherein the first target sequence and the second target sequence are different.

405. The complex of any one of claims 400-404, wherein the first target sequence and the second target sequence are DNA sequences.

406. The complex of claim 405, wherein the first target sequence and the second target sequence are in the genome of a mammal.

407. The complex of claim 406, wherein the first target sequence and the second target sequence are in the genome of a human.

408. The complex of any one of claims 405-407, wherein the first target sequence is within 30 nucleotides of the second target sequence.

409. The complex of any one of claims 405-408, wherein the 3' end of the first target sequence is not immediately adjacent to the canonical PAM sequence (5'-NGG-3 ').

410. The complex of any one of claims 405-409, wherein the 3' end of the second target sequence is not immediately adjacent to the canonical PAM sequence (5'-NGG-3 ').

411. A method comprising contacting a DNA molecule:

(a) with the Cas9 protein of any one of claims 22-123 or the fusion protein of any one of claims 346-373, and with a guide RNA, wherein the guide RNA is about 15-100 nucleotides long and comprises a sequence of at least 10 contiguous nucleotides that is complementary to a target sequence; or

(b) with the complex of any one of claims 391-410.

412. The method of claim 411, wherein the target sequence is a DNA sequence.

413. The method of claim 411 or 412, wherein the 3' end of the target sequence is not immediately adjacent to the canonical PAM sequence (5'-NGG-3').

414. The method of any one of claims 411, wherein the 3' end of the target sequence is immediately adjacent to an AGC, GAG, TTT, GTG, or CAA sequence.

415. The method of any one of claims 411-414, wherein the target sequence comprises a sequence associated with a disease or disorder.

416. The method of claim 415, wherein the target DNA sequence comprises a point mutation associated with a disease or disorder.

417. The method of claim 416, wherein the activity of the Cas9 protein, the Cas9 fusion protein, or the complex results in a correction of the point mutation.

418. The method of any one of claims 411-417, wherein the target DNA sequence comprises a T→C point mutation associated with a disease or disorder, and wherein the deamination of the mutant C base results in a sequence that is not associated with a disease or disorder.

419. The method of claim 418, wherein the target DNA sequence encodes a protein and wherein the point mutation is in a codon and results in a change in the amino acid encoded by the mutant codon as compared to the wild-type codon.

420. The method of claim 419, wherein the deamination of the mutant C results in a change of the amino acid encoded by the mutant codon.

421. The method of claim 420, wherein the deamination of the mutant C results in the codon encoding the wild-type amino acid.

422. The method of any one of claims 411-421, wherein the contacting is in vivo in a subject.

423. The method of claim 422, wherein the subject has or has been diagnosed with a disease or disorder.

424. The method of any one of claims 418-423, wherein the disease or disorder is cystic fibrosis, phenylketonuria, epidermolytic hyperkeratosis (EHK), Charcot-Marie-Toot disease type 4J, neuroblastoma (NB), von Willebrand disease (vWD), myotonia congenital, hereditary renal amyloidosis, dilated cardiomyopathy (DCM), hereditary lymphedema, familial Alzheimer's disease, HIV, Prion disease, chronic infantile neurologic cutaneous articular syndrome (CINCA), desmin-related myopathy (DRM), a neoplastic disease associated with a mutant PI3KCA protein, a mutant CTNNBl protein, a mutant HRAS protein, or a mutant p53 protein.

425. The method of any one of claims 415-423, wherein the disease or disorder is associated with a T>C or A>G mutation in a gene selected from the genes disclosed in Table 6 and 7, respectively.

426. The method of any one of claims 415-423, wherein the disease or disorder is associated with a T>C or A>G mutation in a gene selected from the genes disclosed in Table 6 and 7, respectively.

427. A kit comprising a nucleic acid construct, comprising

(a) a sequence encoding the Cas9 protein of any one of claims 22-123 or the fusion protein of any one of claims 246-373; and

(b) a heterologous promoter that drives expression of the sequence of (a).

428. The kit of claim 427, further comprising an expression construct encoding a guide RNA backbone, wherein the construct comprises a cloning site positioned to allow the cloning of a nucleic acid sequence identical or complementary to a target sequence into the guide RNA backbone.

429. A polynucleotide encoding the Cas9 protein of any one of claims 22-345 or the fusion protein of any one of claims 346-373.

430. A vector comprising a polynucleotide of claim 429.

431. The vector of claim 430, wherein the vector comprises a heterologous promoter driving expression of polynucleotide.

432. A cell comprising the Cas9 protein of any one of claims 22-345 or the fusion protein of any one of claims 346-373, or a nucleic acid molecule encoding the Cas9 protein of any one of claims 22-345 or the fusion protein of any one of claims 346-373.

433. A mutated Cas9 protein that recognizes a non-canonical PAM sequence selected from the group consisting of AAA, AAC, AAG, AAT, CAA, CAC, CAG, CAT, GAA, GAC, GAG, GAT, TAA, TAC, TAG, TAT, ACA, ACC, ACG, ACT, CCA, CCC, CCG, CCT, GCA, GCC, GCG, GCT, TCA, TCC, TCG, TCT, AGA, AGC, AGT, CGA, CGC, CGT, GGA, GGC, GGT, TGA, TGC, TGT, ATA, ATC, ATG, ATT, CTA, CTC, CTG, CTT, GTA, GTC, GTG, GTT, TTA, TTC, TTG, and TTT.

434. The mutated cas9 protein of claim 433, wherein the mutated Cas9 protein comprises any one of the Cas9 proteins of claims 1-345.