WO2010030359A3 - Inhibiteurs macrocycliques de la sérine protéase de l'hépatite c - Google Patents
Inhibiteurs macrocycliques de la sérine protéase de l'hépatite c Download PDFInfo
- Publication number
- WO2010030359A3 WO2010030359A3 PCT/US2009/005082 US2009005082W WO2010030359A3 WO 2010030359 A3 WO2010030359 A3 WO 2010030359A3 US 2009005082 W US2009005082 W US 2009005082W WO 2010030359 A3 WO2010030359 A3 WO 2010030359A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- protease inhibitors
- serine protease
- present
- macrocyclic hepatitis
- macrocyclic
- Prior art date
Links
- 208000006454 hepatitis Diseases 0.000 title 1
- 231100000283 hepatitis Toxicity 0.000 title 1
- 239000003001 serine protease inhibitor Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 150000002678 macrocyclic compounds Chemical class 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Virology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Analytical Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Peptides Or Proteins (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Priority Applications (23)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP09813360.6A EP2340029B1 (fr) | 2008-09-11 | 2009-09-10 | Inhibiteurs macrocycliques de la sérine protéase de l'hépatite c |
DK09813360.6T DK2340029T3 (da) | 2008-09-11 | 2009-09-10 | Makrocykliske hepatitis-C-serinproteaseinhibitorer |
ES09813360.6T ES2459390T3 (es) | 2008-09-11 | 2009-09-10 | Inhibidores macrocíclicos de la serina proteasa de la hepatitis C |
NZ592170A NZ592170A (en) | 2008-09-11 | 2009-09-10 | Macrocyclic hepatitis c serine protease inhibitors |
AU2009292182A AU2009292182B2 (en) | 2008-09-11 | 2009-09-10 | Macrocyclic hepatitis C serine protease inhibitors |
SI200930895T SI2340029T1 (sl) | 2008-09-11 | 2009-09-10 | Makrocikliäśni inhibitorji serin proteaze hepatitisa c |
EA201170434A EA020580B1 (ru) | 2008-09-11 | 2009-09-10 | Макроциклические ингибиторы сериновых протеаз гепатита с |
PL09813360T PL2340029T3 (pl) | 2008-09-11 | 2009-09-10 | Makrocykliczne inhibitory proteazy serynowej wirusa zapalenia wątroby typu C |
UAA201104324A UA103054C2 (en) | 2008-09-11 | 2009-09-10 | Macrocyclic hepatitis c serine protease inhibitors |
MX2011002486A MX2011002486A (es) | 2008-09-11 | 2009-09-10 | Inhibidores de proteasa de serina macrociclicos de hepatitis c. |
CA2736895A CA2736895C (fr) | 2008-09-11 | 2009-09-10 | Inhibiteurs macrocycliques de la serine protease de l'hepatite c |
BRPI0918724A BRPI0918724B8 (pt) | 2008-09-11 | 2009-09-10 | composto inibidor de protease de serina para hepatite c macrocíclica |
BR122012005261A BR122012005261A8 (pt) | 2008-09-11 | 2009-09-10 | Inibidores de protease de serina para hepatite c macrocíclica no tratamento de infecção por hcv |
ZA2011/01558A ZA201101558B (en) | 2008-09-11 | 2011-02-28 | Macrocyclic hepatitis c serine protease inhibitors |
HK12100145.0A HK1159515A1 (en) | 2008-09-11 | 2012-01-06 | Macrocyclic hepatitis c serine protease inhibitors |
IL218441A IL218441A (en) | 2008-09-11 | 2012-03-01 | (2r, 6s, 13as, 14ar, 16as, z) –n– (cyclopropylsulfonyl) –6– (5-methylpyrazine-2-carboxamido) –16, 5, dioxo-2– (phenanthidrine-6-ylaoxy), 1 , 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 13a, 14, 14a, 15, 16, 16a, hexadechydrocycloprope [e] pyrol [1,2 – a] [1, 4] Diazycyclopenadicin - 14a - Carboxamide, or their Acceptable Salts, Used in the Treatment of HCV Infections in Patients |
HRP20140494AT HRP20140494T1 (hr) | 2008-09-11 | 2014-05-29 | Makrocikliäśki inhibitori serin proteaze hepatitisa c |
IL234969A IL234969A0 (en) | 2008-09-11 | 2014-10-02 | Macrocyclic serine protease inhibitors of jaundice c |
LU92667C LU92667I2 (fr) | 2008-09-11 | 2015-02-25 | Paritaprevir, ou un sel ou ester pharmaceutiquement acceptable qui en dérive (viekirax) |
LTPA2015011C LTC2340029I2 (lt) | 2008-09-11 | 2015-03-04 | Makrocikliniai hepatito C serino proteazės inhibitoriai |
CY2015014C CY2015014I1 (el) | 2008-09-11 | 2015-03-26 | Μακροκυκλικοι αναστολεις της πρωτεασης σερινης της ηπατιτιδας c |
NL300730C NL300730I2 (fr) | 2008-09-11 | 2015-04-08 | |
NO2015014C NO2015014I1 (no) | 2008-09-11 | 2015-04-22 | Paritaprevir, eller et farmasøytisk akseptabelt salt eller ester derav |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US19172508P | 2008-09-11 | 2008-09-11 | |
US61/191,725 | 2008-09-11 | ||
US20968909P | 2009-03-10 | 2009-03-10 | |
US61/209,689 | 2009-03-10 |
Publications (3)
Publication Number | Publication Date |
---|---|
WO2010030359A2 WO2010030359A2 (fr) | 2010-03-18 |
WO2010030359A3 true WO2010030359A3 (fr) | 2010-05-27 |
WO2010030359A8 WO2010030359A8 (fr) | 2011-05-12 |
Family
ID=42005677
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2009/005082 WO2010030359A2 (fr) | 2008-09-11 | 2009-09-10 | Inhibiteurs macrocycliques de la sérine protéase de l'hépatite c |
Country Status (41)
Families Citing this family (54)
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UY32099A (es) | 2008-09-11 | 2010-04-30 | Enanta Pharm Inc | Inhibidores macrocíclicos de serina proteasas de hepatitis c |
US8937150B2 (en) * | 2009-06-11 | 2015-01-20 | Abbvie Inc. | Anti-viral compounds |
CN102741270B (zh) * | 2009-09-28 | 2015-07-22 | 英特穆恩公司 | C型肝炎病毒复制的环肽抑制剂 |
US8933110B2 (en) | 2010-01-25 | 2015-01-13 | Enanta Pharmaceuticals, Inc. | Hepatitis C virus inhibitors |
CA2787309A1 (fr) | 2010-01-25 | 2011-07-28 | Enanta Pharmaceuticals, Inc. | Inhibiteurs du virus de l'hepatite c |
KR101579079B1 (ko) * | 2010-03-10 | 2015-12-21 | 애브비 바하마스 리미티드 | 고체 조성물 |
KR20140003521A (ko) * | 2010-12-30 | 2014-01-09 | 이난타 파마슈티칼스, 인코포레이티드 | 페난트리딘 매크로사이클릭 c형 간염 세린 프로테아제 억제제 |
EP2658859A4 (fr) * | 2010-12-30 | 2014-07-30 | Enanta Pharm Inc | Inhibiteurs macrocycliques de sérine protéase d'hépatite c |
US9044480B1 (en) * | 2011-03-03 | 2015-06-02 | Abbvie Inc. | Compositions and methods for treating HCV |
US8957203B2 (en) | 2011-05-05 | 2015-02-17 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
US10201584B1 (en) | 2011-05-17 | 2019-02-12 | Abbvie Inc. | Compositions and methods for treating HCV |
WO2013040568A1 (fr) | 2011-09-16 | 2013-03-21 | Abbvie Inc. | Méthodes de traitement du vhc |
CN103826627B (zh) * | 2011-10-21 | 2016-02-24 | 艾伯维公司 | 包含至少两种直接抗病毒剂和利巴韦林的组合物在制备治疗hcv的药物中的用途 |
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WO2013059638A1 (fr) * | 2011-10-21 | 2013-04-25 | Abbvie Inc. | Polythérapie (par ex. avec abt-072 ou abt-333) s'utilisant pour traiter le vhc |
AU2015200715A1 (en) * | 2011-10-21 | 2015-03-05 | Abbvie Ireland Unlimited Company | Methods for treating HCV |
US9034832B2 (en) | 2011-12-29 | 2015-05-19 | Abbvie Inc. | Solid compositions |
JP6038179B2 (ja) * | 2012-01-11 | 2016-12-07 | アッヴィ・インコーポレイテッド | Hcvプロテアーゼ阻害剤の製造方法 |
JP2015522022A (ja) | 2012-06-27 | 2015-08-03 | アッヴィ・インコーポレイテッド | Hcvの処置に使用するためのabt−450およびリトナビルおよび例えばabt−072および/またはabt−333の併用処置 |
UA119315C2 (uk) | 2012-07-03 | 2019-06-10 | Гіліад Фармассет Елелсі | Інгібітори вірусу гепатиту с |
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TW201408669A (zh) | 2012-08-08 | 2014-03-01 | Merck Sharp & Dohme | Hcv ns3蛋白酶抑制劑 |
AU2012392557B2 (en) | 2012-10-19 | 2017-06-01 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
US9334279B2 (en) | 2012-11-02 | 2016-05-10 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
EP2914613B1 (fr) | 2012-11-02 | 2017-11-22 | Bristol-Myers Squibb Company | Inhibiteurs du virus de l'hépatite c |
US9643999B2 (en) | 2012-11-02 | 2017-05-09 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
WO2014070974A1 (fr) | 2012-11-05 | 2014-05-08 | Bristol-Myers Squibb Company | Inhibiteurs du virus de l'hépatite c |
JP2016505011A (ja) * | 2013-01-10 | 2016-02-18 | ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company | C型肝炎の治療用の大環状ベンゾフランおよびアザベンゾフラン化合物 |
CN105164148A (zh) | 2013-03-07 | 2015-12-16 | 百时美施贵宝公司 | 丙型肝炎病毒抑制剂 |
ES2735355T3 (es) | 2013-03-15 | 2019-12-18 | Gilead Sciences Inc | Inhibidores macrocíclicos y bicíclicos de virus de hepatitis C |
US20150011481A1 (en) | 2013-07-02 | 2015-01-08 | Abbvie Inc. | Methods for Treating HCV |
EP3043803B1 (fr) | 2013-09-11 | 2022-04-27 | Emory University | Compositions à base de nucléotide et de nucléoside et leur utilisations |
WO2015084953A1 (fr) | 2013-12-04 | 2015-06-11 | Abbvie Inc. | Formes cristallines |
WO2015103490A1 (fr) | 2014-01-03 | 2015-07-09 | Abbvie, Inc. | Formes galéniques antivirales solides |
US20150209403A1 (en) | 2014-01-28 | 2015-07-30 | Abbvie Inc. | Dose Adjustment |
US20160074462A1 (en) | 2014-09-11 | 2016-03-17 | Abbvie Inc. | Method of Treating HCV |
US10059969B1 (en) | 2014-10-03 | 2018-08-28 | Abbvie Inc. | Process for the preparation of (S)-2-amino-non-8-enoic acid |
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PE20171061A1 (es) * | 2014-11-10 | 2017-07-21 | Glaxosmithkline Intellectual Property (No 2) Ltd | Composiciones farmaceuticas de accion prolongada para hepatitis c |
WO2016134058A1 (fr) | 2015-02-18 | 2016-08-25 | Abbvie Inc. | Combinaisons utiles pour traiter le virus de l'hépatite c |
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KR20210138684A (ko) | 2019-03-18 | 2021-11-19 | 이난타 파마슈티칼스, 인코포레이티드 | Rsv 억제제로서의 벤조디아제핀 유도체 |
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UY39032A (es) | 2020-01-24 | 2021-07-30 | Enanta Pharm Inc | Compuestos heterocíclicos como agentes antivirales |
CN111378007B (zh) * | 2020-05-08 | 2022-04-12 | 杭州濡湜生物科技有限公司 | 一种采用第二代Hoveyda-Grubbs催化剂制备帕利普韦的方法 |
WO2022010882A1 (fr) | 2020-07-07 | 2022-01-13 | Enanta Pharmaceuticals, Inc, | Dérivés de dihydroquinoxaline et de dihydropyridopyrazine utilisés comme inhibiteurs de rsv |
US11922331B2 (en) | 2020-08-26 | 2024-03-05 | Northrop Grumman Systems Corporation | Machine-learning-based predictive ice detection |
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UY39642A (es) | 2021-02-26 | 2022-09-30 | Enanta Pharm Inc | Compuestos heterocíclicos antivirales |
Citations (3)
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WO2004072243A2 (fr) * | 2003-02-07 | 2004-08-26 | Enanta Pharmaceuticals, Inc. | Inhibiteurs macrocycliques de la serine protease de l'hepatite c |
WO2004093798A2 (fr) * | 2003-04-18 | 2004-11-04 | Enanta Pharmaceuticals, Inc. | Composes macrocycliques de quinoxalinyle inhibant les serine proteases de l'hepatite c |
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