WO2004028610A2 - Medizinische vorrichtung zur arzneimittelabgabe - Google Patents
Medizinische vorrichtung zur arzneimittelabgabe Download PDFInfo
- Publication number
- WO2004028610A2 WO2004028610A2 PCT/EP2003/010480 EP0310480W WO2004028610A2 WO 2004028610 A2 WO2004028610 A2 WO 2004028610A2 EP 0310480 W EP0310480 W EP 0310480W WO 2004028610 A2 WO2004028610 A2 WO 2004028610A2
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- balloon
- substances
- balloons
- tissue
- coated
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/10—Balloon catheters
- A61M25/1002—Balloon catheters characterised by balloon shape
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/54—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/08—Materials for coatings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/08—Materials for coatings
- A61L29/085—Macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/14—Materials characterised by their function or physical properties, e.g. lubricating compositions
- A61L29/16—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/08—Materials for coatings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/16—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/0043—Catheters; Hollow probes characterised by structural features
- A61M25/0045—Catheters; Hollow probes characterised by structural features multi-layered, e.g. coated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/10—Balloon catheters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/10—Balloon catheters
- A61M25/1027—Making of balloon catheters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/41—Anti-inflammatory agents, e.g. NSAIDs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/412—Tissue-regenerating or healing or proliferative agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/416—Anti-neoplastic or anti-proliferative or anti-restenosis or anti-angiogenic agents, e.g. paclitaxel, sirolimus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/43—Hormones, e.g. dexamethasone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/0043—Catheters; Hollow probes characterised by structural features
- A61M2025/0057—Catheters delivering medicament other than through a conventional lumen, e.g. porous walls or hydrogel coatings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/10—Balloon catheters
- A61M25/1002—Balloon catheters characterised by balloon shape
- A61M2025/1004—Balloons with folds, e.g. folded or multifolded
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/10—Balloon catheters
- A61M25/1027—Making of balloon catheters
- A61M25/1029—Production methods of the balloon members, e.g. blow-moulding, extruding, deposition or by wrapping a plurality of layers of balloon material around a mandril
- A61M2025/1031—Surface processing of balloon members, e.g. coating or deposition; Mounting additional parts onto the balloon member's surface
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/10—Balloon catheters
- A61M2025/1043—Balloon catheters with special features or adapted for special applications
- A61M2025/105—Balloon catheters with special features or adapted for special applications having a balloon suitable for drug delivery, e.g. by using holes for delivery, drug coating or membranes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/10—Balloon catheters
- A61M2025/1043—Balloon catheters with special features or adapted for special applications
- A61M2025/1075—Balloon catheters with special features or adapted for special applications having a balloon composed of several layers, e.g. by coating or embedding
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/10—Balloon catheters
- A61M2025/1043—Balloon catheters with special features or adapted for special applications
- A61M2025/1086—Balloon catheters with special features or adapted for special applications having a special balloon surface topography, e.g. pores, protuberances, spikes or grooves
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/10—Balloon catheters
- A61M25/1027—Making of balloon catheters
- A61M25/1038—Wrapping or folding devices for use with balloon catheters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/10—Balloon catheters
- A61M25/104—Balloon catheters used for angioplasty
Definitions
- the invention relates to a medical device for drug delivery for the selective therapy of certain tissue sections or organ parts and a method for producing such drug-coated devices.
- the pharmacotherapy of these diseases is generally carried out by oral or intravenous administration of pharmaceutical substances which are distributed throughout the body and in many cases are undesirable, especially in the case of serious diseases
- Tissue was developed by means of medicinal substances (e.g. antibodies) which bind specifically to diseased tissue while maintaining the route of application or by selective administration, e.g. B. by direct injection into the diseased tissue or by delivery via catheter to the supplying the diseased tissue
- medicinal substances e.g. antibodies
- selective administration e.g. B. by direct injection into the diseased tissue or by delivery via catheter to the supplying the diseased tissue
- catheters are provided with special devices for injecting medicinal products into the arterial wall, for example by means of needles or high injection pressure via a perforation of the catheter wall that lies against the vessel wall.
- drugs in the form of microcapsules for the delayed release of active ingredient are housed loosely in preformed depressions in balloon catheters. After expansion of the balloon, the microcapsules should be pressed into the vessel wall, remain there and slowly release the active ingredient (s).
- Numerous authors also propose to apply drugs embedded in hydrogel to balloon catheters, the Function of the hydrogel as an adhesive, to improve the lubricity or delay the release of the drugs remains open.
- the invention has for its object to provide a device for a limited to certain tissue areas or organ parts drug delivery that exerts a strong therapeutic effect without damaging healthy tissue, the patient is little stressed and can be used and manufactured with little effort.
- the object is achieved with a device designed or manufactured in accordance with the features of claims 1 and 22. Further features and advantageous developments of the invention result from the subclaims.
- the invention provides improved drug-carrying balloon catheters or similar medical devices that are versatile and allow immediate release of the active ingredient in a simple manufacturing process. Surprisingly and contrary to the teaching, no permanent release of active substance from an inert matrix (polymer, hydrogel, microcapsules etc.) or special chemical or physical states of the active substances is necessary or useful. Therefore, no complex techniques for the production or control of depot formulations are required. In many cases, vasoconstrictions hinder the introduction of the balloon into the area of the tissue section to be treated. The diseased tissue sections or organ parts also often have pathological narrowing.
- a balloon catheter is used according to the invention, which has at least one device for slitting stenoses protruding from at least one balloon or sitting on the surface of the balloon Has area of diseased tissue sections or organ parts.
- the device for slitting stenoses can consist of at least one wire-like device, the wire-like device being arranged parallel to the longitudinal axis of the balloon.
- the device consists of at least two wire-like devices and forms a lattice-like construction, the longitudinal axis of the lattice-like construction in turn being arranged parallel or axially parallel to the longitudinal axis of the balloon.
- the device for slitting stenoses to consist of at least one blade-like device or of at least one projection protruding from the balloon or sitting on the surface of the balloon.
- Metals, metal alloys, plastics or combinations thereof are suitable as materials for the manufacture of the blade-like device. In particular, so-called shape memory alloys can also be used.
- calcified vasoconstrictions or in-stent restenoses are slit, which significantly increases the elasticity of the tissue sections treated in this way and also improves the accessibility for the medicinal substances.
- the coating of balloons on catheters with drugs according to the present invention is particularly useful in that after dilating blood vessels or other cavities in the body with the balloons, there is often a need for therapeutic measures to narrow or occlude the balloon prevent pressurized lumens, limit tumor growth, or promote healing processes including collateral circulation.
- This can be achieved by drugs that exert their effect in the immediate vicinity of the balloon surface.
- the drugs adhere firmly to the target on the way to the target - usually through intensely perfused arteries - until the balloon unfolds, are then released to the tissue in an effective dose during the short, often only seconds-long contact time of the deployed balloon and from it in one Recorded way, which avoids the rinsing through the blood flow immediately resuming after deflation of the balloon.
- wires such as those used for guiding catheters, needles and catheters or parts of catheters which are pressed against diseased tissue at least for a short time can also be provided for the coating.
- Preferred catheter materials are polyamides, polyamide mixtures and copolymers, polyethylene terephthalate, polyethylene and copolymers, polyurethane, natural rubber and its derivatives.
- the length and the diameter of the areas of the catheters or balloons intended for pharmacotherapy are not of critical importance for the application, since the dosage is calculated in ⁇ g of active ingredient / mm 2 surface.
- balloons in the range of 2-4 mm in diameter and 1.0-4.0 cm in length are common for coronary dilatations.
- balloons up to> 20 mm in diameter and lengths up to > 10 cm can be used.
- the surfaces to be coated can be smooth (ie without a special structure for receiving the active substances), roughened or provided with structures in any way, special surface structures not being a prerequisite for the adhesion of the active substances, but also not hindering the adhesion.
- the adhesion of the active substances to the balloon surfaces is only achieved through the choice of suitable solvents and, if necessary, additives influencing the adhesion. It is surprisingly firm even on completely smooth balloon surfaces.
- All surfaces can additionally have been or will be coated with substances that improve the lubricity of the products, prevent blood from clotting on the surface or improve other properties of the medical devices, without the materials used for coating having to be released into the environment and without the coating significantly reduces the release of the active substances for the treatment of the target tissue and thus the effectiveness.
- Balloon catheters are formed from very thin plastic tubes by expanding a segment from 1 to approx. 10 cm in length.
- the expanded, very thin-walled balloon membrane is then placed in a plurality of folds arranged longitudinally to the catheter axis and wrapped tightly around the catheter axis, so that the expanded area has a minimally larger diameter than the rest of the catheter when folded.
- the tight folding of the balloon envelope is a prerequisite for the problem-free passage of the balloon catheter through introducer sheaths, guide catheters and e.g. B. severely constricted sections of blood vessels.
- the balloons of catheters can be coated in the folded and unfolded state, whereby an intact, sufficiently uniform coating of the surface is achieved in each case and the active substances also adhere sufficiently firmly to the surface of a balloon catheter coated in the unfolded state.
- a balloon, which is coated in the unfolded state is produced without impairing the coating, for example by using balloon envelopes with preformed folds and bends, the structure of which is not lost in the material due to the expansion and which, after releasing the pressure from the balloon, have the effect that the balloon envelope again folds down at least loosely without any external force being the primary cause. Only then are the pre-formed folds pressed together from the outside or by vacuum. Under no circumstances are wrinkles required to hold the active substance.
- the folding can be brought about by low mechanical forces using very smooth materials, the tools also being able to be wetted, for example, with slippery, biocompatible liquids in which the active ingredients do not dissolve, or at least do not dissolve well.
- the balloons of the fully folded balloon catheter are coated by immersion in low-viscosity active ingredient solutions.
- the solvent and active substance penetrate between the extremely narrow folds and form a surprisingly uniform and dose-reproducible coating that is not damaged by any further work step.
- the solution adhering to the outside or the coating adhering to the outside after the solvent has dried can be left there or removed in a further working step, so that only the active substance hidden by the folds of the balloon is retained.
- a stent After coating, with the balloon folded, a stent can be pushed onto the balloon catheter and pressed onto it. After that, only the sterilization, e.g. B. by means of ethylene oxide, required.
- the work process designed in this way is extremely simple, less susceptible to faults and can also be carried out with mechanically, chemically and physically sensitive coating materials. It has been shown that the Coating according to this method does not lead to any undesired loosening or sticking of the fold and that the active substance applied in this way adheres firmly enough not to be removed on the way through the blood, and on the other hand largely releases the active substance when the balloon in the target tissue inflates.
- the substances are preferably present as a dry solid substance or as an oil on the surfaces of the different medical devices.
- Particles of the smallest size are preferred (in the majority> 5 ⁇ m, preferably> 1 ⁇ m, particularly preferably> 0.1 ⁇ m), particularly preferred are amorphous, non-crystalline structures of the finest particle size which, when in contact with tissue, due to their large surface area despite the generally low water solubility of the medicinal substances dissolve quickly and do not act as microcapsules, ie they spontaneously and quickly dissolve. It is sufficient that there is an effective dose in the form of very small or amorphous particles; Larger particles hardly contribute to the active substance concentration in the tissue, but they do not interfere either.
- the dosage depends on the desired effect and effectiveness of the drug used. It can reach up to 5 ⁇ g / mm 2 , although this is not an upper limit. Lower dosages are easier to implement.
- a matrix substance are low molecular weight (molecular weight ⁇ 5000 D, preferably ⁇ 2000 D) hydrophilic substances such as contrast agents and dyes used in vivo for different diagnostic methods in medicine, sugar and related substances such as sugar alcohols, low molecular weight polyethylene glycols, biocompatible organic and inorganic salts such as e.g. B. benzoates, salts and other derivatives of salicylic acid etc. are suitable.
- contrast medium As a contrast medium, reference is made to the iodinated X-ray contrast medium and the paramagnetic chelates.
- dyes are indocyanine green, fluorescein and methylene blue. Auxiliaries can also serve to improve the shelf life of the products, cause special additional pharmacological effects or serve for quality control.
- the active pharmaceutical ingredients can be adsorbed on particles or applied to the surfaces of suitable medical devices using a low molecular weight matrix.
- the particles are known as biocompatible diagnostics such as ferrites and various contrast agents for sonography.
- Auxiliaries of all kinds can be used in lower or higher doses than the active ingredients.
- the medical devices are coated by means of solutions, suspensions or emulsions of the medicinal substances and auxiliary substances mentioned.
- Solution suspension or emulsion media are, for example, ethanol,
- the application can take place, for example, by dipping, brushing, applying by means of volume measuring devices or spraying in each case at different temperatures and, if appropriate, vapor saturation of the solvents in the atmosphere.
- the process can be repeated several times, if necessary also using different solvents and auxiliary substances.
- the balloons of the completely folded balloon catheter can be coated by immersing them in solutions containing active substances or other measures in a surprisingly uniform, reproducible, dose-controllable manner and without impairing the function of the catheter. Repeated dipping in unsaturated active ingredient solutions does not, contrary to expectations, lead to a complete detachment of the previously applied active ingredient, but to a reproducible increase in the active ingredient content of the balloons.
- the medical devices of various types designed and manufactured according to the invention come into contact with the tissue briefly, ie for seconds, minutes or a few hours.
- it is desirable to pharmacologically treat the tissue in the immediate vicinity of the medical device for example in the case of excessive growth in response to an injury, or to reduce tumor growth, or to promote blood vessel infiltration, or to reduce inflammatory reactions.
- the method described above can achieve a high local drug concentration for an astonishingly long time.
- a major advantage is the extraordinary variety of possible uses for the products and processes described.
- a preferred application is the reduction of the hyperproliferation of the vessel walls induced by the vessel dilation by means of balloon catheters. This is also in the area of possibly implanted stents
- Balloon catheters also treat the areas in need of treatment shortly before and just behind the stent; they can treat the area within existing stents or vessels into which no stent should or cannot be implanted without a new stent implantation. The better one is advantageous compared to the stents which release drug over a long period of time
- Balloon catheters from BMT, Oberpfaffenhofen / Kunststoff, Germany, with the designation Joker Lite, balloon size 2.5 mm x 20 mm, are after maximum Expansion for 1 min. over the entire length of the balloon in ethyl acetate, 18.8 mg paclitaxel / ml, + 1% pharmaceutical olive oil, dipped, dried: paclitaxel content 39 ⁇ g (after extraction with ethanol, HPLC).
- paclitaxel in 9.0 ml acetone; Balloon catheters from BMT, Oberpfaffenhofen / Kunststoff, Germany, with the designation Joker Lite, balloon size 2.5 mm x 20 mm, are in the maximum expanded state for 1 min. dipped over the entire length of the balloon, removed, the solvent is dried at room temperature for 12 h. The balloon is then deflated and folded in with PTFE-coated tools in the usual way.
- a stent of a suitable size can be crimped onto the balloon: 29 ⁇ g paclitaxel on the balloon.
- Example 5 Coating a balloon catheter with paclitaxel in acetone
- the folded balloon sections of the catheters are immersed 5 times, the first time for 1 minute, then 3 hours drying time, then 4 times for 5 seconds each with an interval of 1 hour; then a stent was crimped on and the catheter with stent was sterilized in the usual way with ethylene oxide: paclitaxel content 172 ⁇ g, none detectable by HPLC
- a total of 22 pigs were implanted in the left anterior or lateral coronary artery using the paclitaxel-coated catheter or uncoated catheter stents, with the vessels being slightly overstretched to stimulate restenosis by tissue hyperplasty. After 5 weeks, the animals were reangiographed and the degree of vasoconstriction on the angiograms was measured using an automatic computer program.
- Stenosis percentage reduction in the lumen diameter in the area of the stent compared to the lumen diameter immediately after stent implantation, mean value and statistical significance of the treatment effect.
- the balloons from Example 8 were separated from the balloon catheters over a length of approximately 3 cm and transferred to 1.5 ml of ethanol.
- the paclitaxel content was determined by HPLC. All available coated balloons and a selection of uncoated balloons were examined.
- Example 6 shows that a maximum of 10% of the dose is lost before the balloon is expanded and approximately 10% of the dose remains on the balloon.
- Probucol is introduced at a concentration of 100 mg / ml in acetone; the solution is used to coat the balloon catheter as described in the previous examples.
- Rapamycin is dissolved in a concentration of 10 mg / ml in diethyl ether.
- the balloon portions of the catheters are coated as described in the previous examples; after removal from the coating solution, the balloons should be aligned horizontally as soon as possible and constantly rotated about their longitudinal axis.
- Example 11
- Epothilon B is dissolved in a concentration of 2 mg / ml in ethyl acetate; the solution is used to coat the balloon catheter as described in the previous examples.
- the device 10 consists of a balloon catheter 12 with a catheter 22 and a balloon 14 and a device 24 protruding from the balloon 14 for slitting stenoses at least in the area of the diseased tissue sections or organ parts.
- the device 24 for slitting stenoses consists of six wire-like devices 18 which form a grid-like construction.
- the longitudinal axis of the lattice-like construction is axially parallel to the longitudinal axis of the balloon 14.
- the lattice-like construction is held at both ends by a first and a second connecting element 18, 20.
- the connecting elements 18, 20 not only hold the wire-like devices 18, but also serve to fasten the lattice structure to the catheter 22. Further embodiments with one or more wire-like devices 16 are conceivable.
- the device for slitting stenoses may consist of at least one blade-like device or of at least one projection protruding from the balloon or sitting on the surface of the balloon (not shown).
- Suitable materials for the manufacture of the blade-like device 16 are biocompatible metals such as, for example, stainless steel, metal alloys,
- Shape memory alloys such as nitinol are used.
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Heart & Thoracic Surgery (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Anesthesiology (AREA)
- Biophysics (AREA)
- Pulmonology (AREA)
- Hematology (AREA)
- Molecular Biology (AREA)
- Child & Adolescent Psychology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Surgery (AREA)
- Vascular Medicine (AREA)
- Dermatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Toxicology (AREA)
- Biochemistry (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Cardiology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Materials For Medical Uses (AREA)
- Media Introduction/Drainage Providing Device (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Surgical Instruments (AREA)
Abstract
Description
Claims
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP03750586.4A EP1539267B1 (de) | 2002-09-20 | 2003-09-19 | Medizinische vorrichtung zur arzneimittelabgabe |
JP2004538961A JP4502812B2 (ja) | 2002-09-20 | 2003-09-19 | 医薬品を投与するための医療装置 |
AU2003270229A AU2003270229A1 (en) | 2002-09-20 | 2003-09-19 | Medical device for dispensing medicaments |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE2002144847 DE10244847A1 (de) | 2002-09-20 | 2002-09-20 | Medizinische Vorrichtung zur Arzneimittelabgabe |
DE10244847.7 | 2002-09-20 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2004028610A2 true WO2004028610A2 (de) | 2004-04-08 |
WO2004028610A3 WO2004028610A3 (de) | 2004-06-03 |
Family
ID=31969608
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/DE2003/002871 WO2004028582A1 (de) | 2002-09-20 | 2003-08-26 | Medizinische vorrichtung zur arzneimittelabgabe |
PCT/EP2003/010480 WO2004028610A2 (de) | 2002-09-20 | 2003-09-19 | Medizinische vorrichtung zur arzneimittelabgabe |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/DE2003/002871 WO2004028582A1 (de) | 2002-09-20 | 2003-08-26 | Medizinische vorrichtung zur arzneimittelabgabe |
Country Status (22)
Country | Link |
---|---|
US (7) | US8257305B2 (de) |
EP (9) | EP2857050B1 (de) |
JP (6) | JP2005538812A (de) |
KR (2) | KR101123528B1 (de) |
CN (3) | CN101134120B (de) |
AT (1) | ATE391520T1 (de) |
AU (4) | AU2003269690B2 (de) |
BR (2) | BRPI0314854B8 (de) |
CA (1) | CA2499053C (de) |
CY (1) | CY1112437T1 (de) |
DE (4) | DE10244847A1 (de) |
DK (1) | DK1539266T3 (de) |
ES (3) | ES2620496T3 (de) |
HK (3) | HK1081469A1 (de) |
IL (4) | IL167356A (de) |
MX (1) | MXPA05003041A (de) |
PL (1) | PL217416B1 (de) |
PT (1) | PT1539266E (de) |
RU (1) | RU2316358C2 (de) |
SI (1) | SI1539266T1 (de) |
WO (2) | WO2004028582A1 (de) |
ZA (1) | ZA200502274B (de) |
Cited By (57)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2008061642A2 (de) * | 2006-11-23 | 2008-05-29 | Ruebben Alexander | Verfahren zur erzeugung einer bioaktiven oberfläche auf dem ballon eines ballonkatheters |
WO2008089730A2 (de) * | 2007-01-22 | 2008-07-31 | Eurocor Gmbh | Verfahren zur beladung von strukturierten oberflächen |
WO2009066330A1 (en) | 2007-11-21 | 2009-05-28 | Invatec S.R.L. | Balloon for the treatment of stenosis and method for manufacturing the balloon |
US7572245B2 (en) | 2003-09-15 | 2009-08-11 | Atrium Medical Corporation | Application of a therapeutic substance to a tissue location using an expandable medical device |
WO2009018816A3 (de) * | 2007-08-03 | 2010-01-21 | Invatec Technology Center Gmbh | Verbesserte arzneimittelbeschichtete medizinprodukte, deren herstellung und verwendung |
US7750041B2 (en) | 2001-03-26 | 2010-07-06 | Bayer Schering Pharma Aktiengesellschaft | Preparation for the prophylaxis of restenosis |
US7759374B2 (en) | 2002-08-23 | 2010-07-20 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto and analogues thereof |
US7803149B2 (en) | 2002-07-12 | 2010-09-28 | Cook Incorporated | Coated medical device |
US7875638B2 (en) | 2002-08-23 | 2011-01-25 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto, analogues and uses thereof |
EP2285443A2 (de) * | 2008-05-01 | 2011-02-23 | Bayer Schering Pharma AG | Wirkstoffhafttechniken und verfahren für katheterballon |
WO2011044889A1 (de) * | 2009-10-16 | 2011-04-21 | Hemoteq Ag | Verwendung von zusammensetzungen zur beschichtung von katheterballons und beschichtete katheterballons |
US7947015B2 (en) | 1999-01-25 | 2011-05-24 | Atrium Medical Corporation | Application of a therapeutic substance to a tissue location using an expandable medical device |
US8021331B2 (en) | 2003-09-15 | 2011-09-20 | Atrium Medical Corporation | Method of coating a folded medical device |
US8080026B2 (en) | 2003-01-21 | 2011-12-20 | Angioscore, Inc. | Apparatus and methods for treating hardened vascular lesions |
WO2012009412A1 (en) * | 2010-07-16 | 2012-01-19 | Abbott Cardiovascular Systems Inc. | Medical device having tissue engaging member and method for delivery of a therapeutic agent |
DE102011000340A1 (de) | 2010-12-04 | 2012-06-06 | Alexander Rübben | Beschichtung und Beschichtungsverfahren für den Ballon eines Ballonkatheters sowie Ballonkatheter mit beschichtetem Ballon |
WO2012072074A1 (de) | 2010-12-04 | 2012-06-07 | Ruebben Alexander | Beschichtung und beschichtungsverfahren für den ballon eines ballonkatheters sowie ballonkatheter mit beschichtetem ballon |
WO2012084024A1 (en) | 2010-12-21 | 2012-06-28 | Invatec Technology Center Gmbh | Drug eluting balloon for the treatment of stenosis and method for manufacturing the balloon |
US8257305B2 (en) | 2002-09-20 | 2012-09-04 | Bayer Pharma Aktiengesellschaft | Medical device for dispensing medicaments |
US8613721B2 (en) | 2007-11-14 | 2013-12-24 | Medrad, Inc. | Delivery and administration of compositions using interventional catheters |
US8734825B2 (en) | 2008-09-15 | 2014-05-27 | Covidien Lp | Local delivery of water-soluble or water-insoluble therapeutic agents to the surface of body lumens |
US9034362B2 (en) | 2008-09-15 | 2015-05-19 | The Spectranetics Corporation | Local delivery of water-soluble or water-insoluble therapeutic agents to the surface of body lumens |
US9050442B2 (en) | 1999-01-25 | 2015-06-09 | Atrium Medical Corporation | Expandable fluoropolymer device for delivery of therapeutic agents and method of making |
US9056152B2 (en) | 2011-08-25 | 2015-06-16 | Boston Scientific Scimed, Inc. | Medical device with crystalline drug coating |
US9173977B2 (en) | 2010-04-19 | 2015-11-03 | Angioscore, Inc. | Coating formulations for scoring or cutting balloon catheters |
US9180485B2 (en) | 2008-08-29 | 2015-11-10 | Lutonix, Inc. | Methods and apparatuses for coating balloon catheters |
US9351756B2 (en) | 2010-09-21 | 2016-05-31 | Angioscore, Inc. | Method and system for treating valve stenosis |
US9375328B2 (en) | 2001-11-09 | 2016-06-28 | Angioscore, Inc. | Balloon catheter with non-deployable stent |
EP2944332B1 (de) | 2009-07-10 | 2016-08-17 | Boston Scientific Scimed, Inc. | Verwendung von nanokristallen für einen wirkstofffreisetzungsballon |
US9586031B2 (en) | 2005-05-11 | 2017-03-07 | Angioscore, Inc. | Methods and systems for delivering substances into luminal walls |
EP3150236A1 (de) * | 2006-02-09 | 2017-04-05 | B. Braun Melsungen AG | Faltenballonbeschichtungsverfahren |
US9694111B2 (en) | 2006-11-20 | 2017-07-04 | Lutonix, Inc. | Medical device rapid drug releasing coatings comprising a therapeutic agent and a contrast agent |
US9700704B2 (en) | 2006-11-20 | 2017-07-11 | Lutonix, Inc. | Drug releasing coatings for balloon catheters |
US9730820B2 (en) | 2008-09-25 | 2017-08-15 | Abbott Cardiovascular Systems Inc. | Stent delivery system having a fibrous matrix covering with improved stent retention |
US9737640B2 (en) | 2006-11-20 | 2017-08-22 | Lutonix, Inc. | Drug releasing coatings for medical devices |
US9737691B2 (en) | 2006-11-20 | 2017-08-22 | Lutonix, Inc. | Drug releasing coatings for balloon catheters |
US9757351B2 (en) | 2006-11-20 | 2017-09-12 | Lutonix, Inc. | Medical device rapid drug releasing coatings comprising oils, fatty acids and/or lipids |
EP3088013A4 (de) * | 2013-12-26 | 2017-09-13 | Lifetech Scientific (Shenzhen) Co., Ltd. | Medikamentenbeschichteter ballonkatheter |
US9764065B2 (en) | 2006-11-20 | 2017-09-19 | Lutonix, Inc. | Drug releasing coatings for medical devices |
US9937159B2 (en) | 2006-11-20 | 2018-04-10 | Lutonix, Inc. | Treatment of asthma and chronic obstructive pulmonary disease with anti-proliferate and anti-inflammatory drugs |
US9956385B2 (en) | 2012-06-28 | 2018-05-01 | The Spectranetics Corporation | Post-processing of a medical device to control morphology and mechanical properties |
US10046093B2 (en) | 2008-09-15 | 2018-08-14 | The Spectranetics Corporation | Local delivery of water-soluble or water-insoluble therapeutic agents to the surface of body lumens |
US10080821B2 (en) | 2009-07-17 | 2018-09-25 | Boston Scientific Scimed, Inc. | Nucleation of drug delivery balloons to provide improved crystal size and density |
US10086178B2 (en) | 2001-11-09 | 2018-10-02 | Angioscore, Inc. | Balloon catheter with non-deployable stent |
US10117668B2 (en) | 2013-10-08 | 2018-11-06 | The Spectranetics Corporation | Balloon catheter with non-deployable stent having improved stability |
US10195311B2 (en) | 2009-12-18 | 2019-02-05 | Interface Biologics, Inc. | Local delivery of drugs from self assembled coatings |
US10525171B2 (en) | 2014-01-24 | 2020-01-07 | The Spectranetics Corporation | Coatings for medical devices |
US10532189B2 (en) | 2007-08-29 | 2020-01-14 | Invatec Technology Center Gmbh | Controlled expansion balloon catheter |
US10772995B2 (en) | 2004-09-28 | 2020-09-15 | Atrium Medical Corporation | Cross-linked fatty acid-based biomaterials |
US10792312B2 (en) | 2004-09-28 | 2020-10-06 | Atrium Medical Corporation | Barrier layer |
US10814043B2 (en) | 2004-09-28 | 2020-10-27 | Atrium Medical Corporation | Cross-linked fatty acid-based biomaterials |
US10864304B2 (en) | 2009-08-11 | 2020-12-15 | Atrium Medical Corporation | Anti-infective antimicrobial-containing biomaterials |
US10888617B2 (en) | 2012-06-13 | 2021-01-12 | Atrium Medical Corporation | Cured oil-hydrogel biomaterial compositions for controlled drug delivery |
US11083823B2 (en) | 2005-09-28 | 2021-08-10 | Atrium Medical Corporation | Tissue-separating fatty acid adhesion barrier |
US11097035B2 (en) | 2010-07-16 | 2021-08-24 | Atrium Medical Corporation | Compositions and methods for altering the rate of hydrolysis of cured oil-based materials |
US11166929B2 (en) | 2009-03-10 | 2021-11-09 | Atrium Medical Corporation | Fatty-acid based particles |
US11318232B2 (en) | 2018-05-22 | 2022-05-03 | Interface Biologics, Inc. | Compositions and methods for delivering drugs to a vessel wall |
Families Citing this family (163)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6774278B1 (en) | 1995-06-07 | 2004-08-10 | Cook Incorporated | Coated implantable medical device |
EP0975340B2 (de) | 1997-03-31 | 2009-10-28 | Boston Scientific Limited | Verwendung von cytoskelettinhibitoren zur vorbeugung der restenose |
US8177743B2 (en) | 1998-05-18 | 2012-05-15 | Boston Scientific Scimed, Inc. | Localized delivery of drug agents |
US7686824B2 (en) * | 2003-01-21 | 2010-03-30 | Angioscore, Inc. | Apparatus and methods for treating hardened vascular lesions |
US9278015B2 (en) * | 2003-10-16 | 2016-03-08 | Minvasys | Catheter system for stenting and drug treatment of bifurcated vessels |
EP1699527A1 (de) | 2004-01-02 | 2006-09-13 | Advanced Cardiovascular Systems, Inc. | Mit lipoprotein hoher dichte beschichtete medizinprodukte |
US7349971B2 (en) * | 2004-02-05 | 2008-03-25 | Scenera Technologies, Llc | System for transmitting data utilizing multiple communication applications simultaneously in response to user request without specifying recipient's communication information |
US20070027523A1 (en) * | 2004-03-19 | 2007-02-01 | Toner John L | Method of treating vascular disease at a bifurcated vessel using coated balloon |
US8431145B2 (en) * | 2004-03-19 | 2013-04-30 | Abbott Laboratories | Multiple drug delivery from a balloon and a prosthesis |
US20100030183A1 (en) * | 2004-03-19 | 2010-02-04 | Toner John L | Method of treating vascular disease at a bifurcated vessel using a coated balloon |
US8003122B2 (en) * | 2004-03-31 | 2011-08-23 | Cordis Corporation | Device for local and/or regional delivery employing liquid formulations of therapeutic agents |
WO2006026531A1 (en) * | 2004-08-27 | 2006-03-09 | Cordis Corporation | Solvent free amorphous rapamycin |
EP3345632A1 (de) * | 2005-02-18 | 2018-07-11 | Abraxis BioScience, LLC | Arzneimittel mit verbesserter hydrophobie zur einarbeitung in medizinische vorrichtungen |
US7763198B2 (en) * | 2005-04-12 | 2010-07-27 | Abbott Cardiovascular Systems Inc. | Method for retaining a vascular stent on a catheter |
US20080243068A1 (en) * | 2005-12-29 | 2008-10-02 | Kamal Ramzipoor | Methods and apparatus for treatment of venous insufficiency |
US7919108B2 (en) * | 2006-03-10 | 2011-04-05 | Cook Incorporated | Taxane coatings for implantable medical devices |
US8888800B2 (en) | 2006-03-13 | 2014-11-18 | Pneumrx, Inc. | Lung volume reduction devices, methods, and systems |
US8157837B2 (en) * | 2006-03-13 | 2012-04-17 | Pneumrx, Inc. | Minimally invasive lung volume reduction device and method |
US9402633B2 (en) | 2006-03-13 | 2016-08-02 | Pneumrx, Inc. | Torque alleviating intra-airway lung volume reduction compressive implant structures |
US8153181B2 (en) * | 2006-11-14 | 2012-04-10 | Boston Scientific Scimed, Inc. | Medical devices and related methods |
EP2322235A1 (de) * | 2006-11-20 | 2011-05-18 | Lutonix, Inc. | Wirkstofffreisetzende Beschichtungen für medizinische Vorrichtungen |
US8414525B2 (en) | 2006-11-20 | 2013-04-09 | Lutonix, Inc. | Drug releasing coatings for medical devices |
US8998846B2 (en) | 2006-11-20 | 2015-04-07 | Lutonix, Inc. | Drug releasing coatings for balloon catheters |
US20080140002A1 (en) * | 2006-12-06 | 2008-06-12 | Kamal Ramzipoor | System for delivery of biologically active substances with actuating three dimensional surface |
EP2491962A1 (de) * | 2007-01-21 | 2012-08-29 | Hemoteq AG | Medizinprodukt zur Behandlung von Verschlüssen von Körperdurchgängen und zur Prävention drohender Wiederverschlüsse |
DE102007008479A1 (de) * | 2007-02-21 | 2008-09-04 | Orlowski, Michael, Dr. | Beschichtetes Expandierbares System |
JP2008206702A (ja) * | 2007-02-26 | 2008-09-11 | Nipro Corp | カテーテル用バルーン |
JP2008305262A (ja) * | 2007-06-08 | 2008-12-18 | Konica Minolta Business Technologies Inc | サーバ及びシンクライアント環境でのプリンタ紹介方法 |
US9370642B2 (en) | 2007-06-29 | 2016-06-21 | J.W. Medical Systems Ltd. | Adjustable-length drug delivery balloon |
US9192697B2 (en) | 2007-07-03 | 2015-11-24 | Hemoteq Ag | Balloon catheter for treating stenosis of body passages and for preventing threatening restenosis |
DE102007034991A1 (de) * | 2007-07-26 | 2009-01-29 | Biotronik Vi Patent Ag | Verfahren zur Herstellung eines gecrimpten Stents, Verwendung einer Polymerbeschichtung und Medizinprodukte |
CN101883605A (zh) * | 2007-09-06 | 2010-11-10 | 波士顿科学西美德公司 | 用于传递局部用治疗剂至心脏瓣膜的方法和装置 |
US8992471B2 (en) * | 2007-11-05 | 2015-03-31 | Nanocopoeia, Inc. | Coated devices and method of making coated devices that reduce smooth muscle cell proliferation and platelet activity |
DE102008008263A1 (de) | 2008-02-08 | 2009-08-13 | Thomas Kuczera | Restenoseprophylaxe |
DE102008008926A1 (de) * | 2008-02-13 | 2009-08-20 | Biotronik Vi Patent Ag | System zum Einbringen einer intraluminalen Endoprothese und Verfahren zur Herstellung eines derartigen Systems |
EP2262547B1 (de) | 2008-03-06 | 2013-01-09 | Boston Scientific Scimed, Inc. | Ballonkathetervorrichtungen mit in lösungsmittel quellbarem polymer |
AU2014240352B2 (en) * | 2008-03-31 | 2016-05-19 | Cardinal Health 529, Llc | Device for local and/or regional delivery employing liquid formulations of therapeutic agents |
US8409601B2 (en) * | 2008-03-31 | 2013-04-02 | Cordis Corporation | Rapamycin coated expandable devices |
US9114125B2 (en) * | 2008-04-11 | 2015-08-25 | Celonova Biosciences, Inc. | Drug eluting expandable devices |
DE202008006190U1 (de) | 2008-05-06 | 2008-07-17 | Sellin, Lothar | Restenoseprophylaxe |
DE202008007347U1 (de) | 2008-05-31 | 2008-10-16 | Orlowski, Benjamin Daniel | Kupfer Stent |
DE112009001065A5 (de) | 2008-05-31 | 2011-04-14 | Lothar Sellin | Medizinische Einrichtung und Verfahren zu ihrer Herstellung |
DE102008034826A1 (de) * | 2008-07-22 | 2010-01-28 | Alexander Rübben | Verfahren zur Erzeugung einer bioaktiven Oberfläche auf dem Ballon eines Ballonkatheters |
US9067045B2 (en) | 2008-07-25 | 2015-06-30 | Cook Medical Technologies Llc | Balloon catheter and method for making same |
US8642063B2 (en) | 2008-08-22 | 2014-02-04 | Cook Medical Technologies Llc | Implantable medical device coatings with biodegradable elastomer and releasable taxane agent |
EP2331187A4 (de) * | 2008-09-02 | 2011-09-28 | By Pass Inc | Mikroporöser ballonkatheter |
US8367090B2 (en) * | 2008-09-05 | 2013-02-05 | Abbott Cardiovascular Systems Inc. | Coating on a balloon comprising a polymer and a drug |
US8632605B2 (en) | 2008-09-12 | 2014-01-21 | Pneumrx, Inc. | Elongated lung volume reduction devices, methods, and systems |
US8128951B2 (en) | 2008-09-15 | 2012-03-06 | Cv Ingenuity Corp. | Local delivery of water-soluble or water-insoluble therapeutic agents to the surface of body lumens |
US8226603B2 (en) | 2008-09-25 | 2012-07-24 | Abbott Cardiovascular Systems Inc. | Expandable member having a covering formed of a fibrous matrix for intraluminal drug delivery |
US8049061B2 (en) | 2008-09-25 | 2011-11-01 | Abbott Cardiovascular Systems, Inc. | Expandable member formed of a fibrous matrix having hydrogel polymer for intraluminal drug delivery |
US8076529B2 (en) | 2008-09-26 | 2011-12-13 | Abbott Cardiovascular Systems, Inc. | Expandable member formed of a fibrous matrix for intraluminal drug delivery |
DE102009059070A1 (de) | 2008-12-19 | 2010-07-01 | Lothar Sellin | Medizinische Einrichtung und Verfahren zu ihrer Herstellung |
IT1394523B1 (it) * | 2009-01-09 | 2012-07-05 | Invatec Technology Ct Gmbh | Dispositivo medicale con rilascio di farmaco |
IT1394522B1 (it) * | 2009-01-09 | 2012-07-05 | Invatec Technology Ct Gmbh | Dispositivo medicale con rilascio di farmaco |
DE102009011931A1 (de) | 2009-03-10 | 2010-09-16 | Innora Gmbh | Vorrichtung zur Applikation von Wirkstoffen auf die Wand eines Körpergefäßes |
US20100261662A1 (en) * | 2009-04-09 | 2010-10-14 | Endologix, Inc. | Utilization of mural thrombus for local drug delivery into vascular tissue |
WO2010120620A1 (en) | 2009-04-13 | 2010-10-21 | Cook Incorporated | Coated balloon catheter |
EP2243501A1 (de) | 2009-04-24 | 2010-10-27 | Eurocor Gmbh | Schellack- und paclitaxel-beschichtete Katheterballons |
SG175373A1 (en) | 2009-04-28 | 2011-11-28 | Surmodics Inc | Devices and methods for delivery of bioactive agents |
US20100285085A1 (en) * | 2009-05-07 | 2010-11-11 | Abbott Cardiovascular Systems Inc. | Balloon coating with drug transfer control via coating thickness |
DE202009006632U1 (de) | 2009-05-07 | 2009-07-16 | Sellin, Lothar | Beschichtung von medizinischen Oberflächen |
CN104622599B (zh) | 2009-05-18 | 2017-04-12 | 纽姆克斯股份有限公司 | 细长的肺减容装置在部署过程中的横截面变化 |
US9265633B2 (en) | 2009-05-20 | 2016-02-23 | 480 Biomedical, Inc. | Drug-eluting medical implants |
WO2010136604A1 (en) * | 2009-05-29 | 2010-12-02 | Dsm Ip Assets B.V. | Transfer matrix for transferring a bioactive agent to body tissue |
ES2676537T3 (es) * | 2009-06-02 | 2018-07-20 | Concept Medical Inc. | Rejuvenecimiento de la arteria coronaria mediante la mejora del flujo sanguíneo con la ayuda de la inserción de nano-bolas (nanopartículas encapsuladas) que contienen agentes terapéuticos por medio de un dispositivo no implantable para tejidos y, de esta forma, proporcionar liberación en el tejido para tratar el ciclo de célula requerido |
CN102711674A (zh) | 2009-08-26 | 2012-10-03 | 大塚医疗器械有限公司 | 管腔内留置用医疗设备及其制造方法 |
EP2452701A4 (de) | 2009-08-27 | 2014-04-23 | Terumo Corp | Medizinische vorrichtung zur abgabe von arzneimitteln |
DE202009014776U1 (de) | 2009-11-02 | 2010-03-11 | Sellin, Lothar | Beschichtung |
EP2501431B1 (de) * | 2009-11-19 | 2020-01-08 | Wellinq Medical B.V. | Eluirender, erweiterbarer medizinischer ballonkatheter mit niederprofil |
US20120330132A1 (en) | 2009-12-07 | 2012-12-27 | Paul Sorajja | Device for the Delineation of Cardiovascular or Other Anatomical Structures |
US8951595B2 (en) * | 2009-12-11 | 2015-02-10 | Abbott Cardiovascular Systems Inc. | Coatings with tunable molecular architecture for drug-coated balloon |
US20110144577A1 (en) * | 2009-12-11 | 2011-06-16 | John Stankus | Hydrophilic coatings with tunable composition for drug coated balloon |
US8480620B2 (en) * | 2009-12-11 | 2013-07-09 | Abbott Cardiovascular Systems Inc. | Coatings with tunable solubility profile for drug-coated balloon |
DE202009017490U1 (de) | 2009-12-22 | 2010-04-08 | Sellin, Lothar | Weihrauch- und/oder Boswelliasäuren Beschichtung |
US9199066B2 (en) | 2010-03-12 | 2015-12-01 | Quattro Vascular Pte Ltd. | Device and method for compartmental vessel treatment |
CN102946936B (zh) * | 2010-03-30 | 2016-05-04 | 火花医学研究有限公司 | 药物释放医用导管、管和装置 |
EP2380605A1 (de) | 2010-04-19 | 2011-10-26 | InnoRa Gmbh | Verbesserte Formulierungen für wirkstoffbeschichtete medizinische Vorrichtungen |
EP2383000A1 (de) | 2010-04-19 | 2011-11-02 | InnoRa Gmbh | Limusbeschichtete medizinische Vorrichtungen |
DE102010022588A1 (de) | 2010-05-27 | 2011-12-01 | Hemoteq Ag | Ballonkatheter mit einer partikelfrei Wirkstoff-abgebenden Beschichtung |
EP2611474A1 (de) | 2010-06-03 | 2013-07-10 | Capsulution Pharma AG | Beschichtung eines medikamentenbeschichteten medizinprodukts |
WO2011151413A1 (en) | 2010-06-03 | 2011-12-08 | Capsulution Pharma Ag | Coating of a drug-eluting medical device |
WO2012003293A1 (en) * | 2010-06-30 | 2012-01-05 | Surmodics, Inc. | Lipid coating for medical devices delivering bioactive agent |
WO2012031236A1 (en) | 2010-09-02 | 2012-03-08 | Boston Scientific Scimed, Inc. | Coating process for drug delivery balloons using heat-induced rewrap memory |
US20120078227A1 (en) | 2010-09-23 | 2012-03-29 | Boston Scientific Scimed, Inc. | Drug Coated Balloon Composition with High Drug Transfer to Vessel |
RU2521690C2 (ru) * | 2010-11-02 | 2014-07-10 | Заза Александрович Кавтеладзе | Устройство для передачи лекарственных веществ на стенку кровеносного сосуда |
DE102010055560B4 (de) * | 2010-12-23 | 2017-02-23 | Heraeus Medical Gmbh | Beschichtungsvorrichtung |
DE202011002713U1 (de) | 2011-02-14 | 2011-04-14 | Sellin, Lothar | Biologisch abbaubare medizinische Beschichtung und deren Verwendung |
DE102011100122A1 (de) | 2011-04-26 | 2012-10-31 | Eurocor Gmbh | Katheterballon beschichtet mit Rapamycin und Schellack |
SG10201606406PA (en) * | 2011-04-28 | 2016-09-29 | Abraxis Bioscience Llc | Intravascular delivery of nanoparticle compositions and uses thereof |
WO2012156914A2 (en) | 2011-05-15 | 2012-11-22 | By-Pass, Inc. | Microporous balloon catheter, delivery system, and methods of manufacture and use |
US9757497B2 (en) | 2011-05-20 | 2017-09-12 | Surmodics, Inc. | Delivery of coated hydrophobic active agent particles |
US10213529B2 (en) | 2011-05-20 | 2019-02-26 | Surmodics, Inc. | Delivery of coated hydrophobic active agent particles |
US9861727B2 (en) | 2011-05-20 | 2018-01-09 | Surmodics, Inc. | Delivery of hydrophobic active agent particles |
CN102847200B (zh) * | 2011-06-28 | 2014-09-17 | 先健科技(深圳)有限公司 | 静电自组装载药层的制备方法 |
WO2013007273A1 (en) | 2011-07-08 | 2013-01-17 | Cardionovum Sp.Z.O.O. | Balloon surface coating |
WO2013022458A1 (en) | 2011-08-05 | 2013-02-14 | Boston Scientific Scimed, Inc. | Methods of converting amorphous drug substance into crystalline form |
ES2527276T3 (es) | 2011-09-29 | 2015-01-22 | Cardionovum Gmbh | Balón con superficie recubierta |
WO2013053809A1 (en) | 2011-10-14 | 2013-04-18 | Innora Gmbh | Improved formulations for drug-coated medical devices |
DE202011106744U1 (de) | 2011-10-15 | 2011-11-11 | Lothar Sellin | Bessere Bioverfügbarkeit von Shellac/Paclitaxel Beschichtungen |
WO2013079476A1 (de) | 2011-11-30 | 2013-06-06 | Bayer Materialscience Ag | Arzneimittelbeschichtetes medizinisches gerät und verfahren zu dessen herstellung |
WO2013091722A1 (en) | 2011-12-23 | 2013-06-27 | Innora Gmbh | Drug-coated medical devices |
DE102012001188A1 (de) * | 2012-01-24 | 2013-07-25 | Qualimed Innovative Medizinprodukte Gmbh | Ballonkatheter |
JP2015505497A (ja) | 2012-02-01 | 2015-02-23 | クアトロ・ヴァスキュラー・ピーティーイー・リミテッド | 血管の区画による拡張のためのデバイス |
US9179936B2 (en) | 2012-02-08 | 2015-11-10 | Quattro Vascular Pte Ltd. | Constraining structure with non-linear axial struts |
US9216033B2 (en) | 2012-02-08 | 2015-12-22 | Quattro Vascular Pte Ltd. | System and method for treating biological vessels |
US9220759B2 (en) | 2012-02-23 | 2015-12-29 | Abbott Cardiovascular Systems Inc. | Treatment of diabetic patients with a drug eluting stent and adjunctive therapy |
US20150112256A1 (en) * | 2012-03-09 | 2015-04-23 | Clearstream Technologies Limited | Medical balloon with radiopaque identifier for precisely identifying the working surface |
JP6042876B2 (ja) | 2012-03-27 | 2016-12-14 | テルモ株式会社 | コーティング組成物および医療機器 |
CN104168927B (zh) | 2012-03-27 | 2016-10-05 | 泰尔茂株式会社 | 涂布组合物及医疗器械 |
US20130259921A1 (en) * | 2012-03-30 | 2013-10-03 | Abbott Cardiovascular Systems Inc. | Treatment Of Diabetic Patients With A Stent And An Adjunctive Drug Formulation |
US9220584B2 (en) | 2012-03-30 | 2015-12-29 | Abbott Cardiovascular Systems Inc. | Treatment of diabetic patients with a stent and locally administered adjunctive therapy |
EP2872192B1 (de) * | 2012-07-10 | 2020-12-23 | Bayer Pharma Aktiengesellschaft | Katheter mit medikamentenbeschichtung |
WO2014008875A1 (de) | 2012-07-12 | 2014-01-16 | Cardionovum Gmbh | Katheterballon, verfahren zur herstellung eines beschichteten katheterballons sowie verwendung des pharmakologischen wirkstoffs |
WO2014029442A1 (en) | 2012-08-23 | 2014-02-27 | Cardionovum Gmbh | Balloon surface coating for valvuloplasty |
JP6068921B2 (ja) * | 2012-10-19 | 2017-01-25 | ホソカワミクロン株式会社 | 薬剤溶出型デバイスの製造方法 |
US10881839B2 (en) | 2012-10-26 | 2021-01-05 | Urotronic, Inc. | Drug-coated balloon catheters for body lumens |
US10898700B2 (en) | 2012-10-26 | 2021-01-26 | Urotronic, Inc. | Balloon catheters for body lumens |
US10806830B2 (en) | 2012-10-26 | 2020-10-20 | Urotronic, Inc. | Drug-coated balloon catheters for body lumens |
US11938287B2 (en) | 2012-10-26 | 2024-03-26 | Urotronic, Inc. | Drug-coated balloon catheters for body lumens |
US10850076B2 (en) | 2012-10-26 | 2020-12-01 | Urotronic, Inc. | Balloon catheters for body lumens |
CN104936629A (zh) | 2012-10-26 | 2015-09-23 | 优敦力公司 | 用于非血管狭窄的药物涂层球囊导管 |
US11504450B2 (en) | 2012-10-26 | 2022-11-22 | Urotronic, Inc. | Drug-coated balloon catheters for body lumens |
JP2013066727A (ja) * | 2012-10-30 | 2013-04-18 | Japan Stent Technology Co Ltd | ステントの製造方法 |
US11246963B2 (en) | 2012-11-05 | 2022-02-15 | Surmodics, Inc. | Compositions and methods for delivery of hydrophobic active agents |
CA2890205C (en) | 2012-11-05 | 2020-12-22 | Surmodics, Inc. | Composition and method for delivery of hydrophobic active agents |
IE20130079A1 (en) | 2013-02-13 | 2014-09-10 | Patrick T Prendergast | Method for loading dilatable catheter balloons and dilatation catheters obtained therefrom |
DE202013002567U1 (de) | 2013-03-18 | 2013-05-07 | Lothar Sellin | NABP - Beschichtung |
WO2014177221A1 (en) | 2013-05-02 | 2014-11-06 | Cardionovum Gmbh | Balloon surface coating |
US9660244B2 (en) * | 2013-09-06 | 2017-05-23 | Johnson Controls Technology Company | System and method for establishing connections of a battery module |
WO2015061790A2 (en) | 2013-10-25 | 2015-04-30 | Pneumrx, Inc. | Genetically-associated chronic obstructive pulmonary disease treatment |
US20150190618A1 (en) | 2014-01-09 | 2015-07-09 | Medtronic Vascular, Inc. | Balloon Catheter With Elastomeric Sheath and Methods |
CN106163602B (zh) | 2014-04-01 | 2019-11-01 | 泰尔茂株式会社 | 球囊涂敷方法、涂敷层控制方法及球囊涂敷装置 |
JP2015195962A (ja) * | 2014-04-01 | 2015-11-09 | テルモ株式会社 | バルーンコーティング方法 |
DE102014106422A1 (de) | 2014-05-08 | 2015-11-12 | Dot Gmbh | Verfahren, Vorrichtung und Zusammensetzung zur Herstellung von beschichteten Ballonkathetern |
KR101656852B1 (ko) * | 2014-06-16 | 2016-09-19 | 주식회사 제노스 | 풍선 카테터, 그 제조 방법, 및 풍선 카테터의 풍선 코팅용 조성물 |
US9655998B2 (en) | 2014-08-07 | 2017-05-23 | Cook Medical Technologies Llc | Encapsulated drug compositions and methods of use thereof |
US9180226B1 (en) | 2014-08-07 | 2015-11-10 | Cook Medical Technologies Llc | Compositions and devices incorporating water-insoluble therapeutic agents and methods of the use thereof |
US11241520B2 (en) | 2014-08-07 | 2022-02-08 | Cook Medical Technologies Llc | Compositions and devices incorporating water-insoluble therapeutic agents and methods of the use thereof |
US10390838B1 (en) | 2014-08-20 | 2019-08-27 | Pneumrx, Inc. | Tuned strength chronic obstructive pulmonary disease treatment |
US9675734B2 (en) | 2014-08-29 | 2017-06-13 | Invatec S.P.A. | Medical balloon coated with therapeutic agent, carboxylic acid, and salt thereof |
JP6820745B2 (ja) | 2014-10-28 | 2021-01-27 | 株式会社Jimro | 薬剤溶出型ステント |
EP3220994B1 (de) | 2014-11-17 | 2021-01-06 | TriReme Medical, LLC | Ballonkathetersystem |
CN118320191A (zh) | 2015-04-24 | 2024-07-12 | 优敦力公司 | 用于非血管狭窄的药物涂布的球囊导管 |
US11904072B2 (en) | 2015-04-24 | 2024-02-20 | Urotronic, Inc. | Drug coated balloon catheters for nonvascular strictures |
CN104922735B (zh) * | 2015-06-24 | 2017-03-22 | 浙江巴泰医疗科技有限公司 | 一种药物球囊的制备方法 |
GB201512030D0 (en) * | 2015-07-09 | 2015-08-19 | Jmedtech Pte Ltd | Composition |
EP3368133B1 (de) * | 2015-10-30 | 2020-04-01 | Acotec Scientific Co. Ltd | Arteriovenöser shunt mit medikamentenbeschichtetem ballonkatheter |
US11147952B2 (en) * | 2016-04-28 | 2021-10-19 | Medtronic Vascular, Inc. | Drug coated inflatable balloon having a thermal dependent release layer |
DE102016110815B4 (de) | 2016-06-13 | 2018-05-17 | Dot Gmbh | Beschichteter Ballonkatheter und Zusammensetzung zur Beschichtung des Ballonkatheters |
WO2018008518A1 (ja) | 2016-07-04 | 2018-01-11 | 株式会社カネカ | バルーンカテーテルおよびその製造方法 |
US10898446B2 (en) | 2016-12-20 | 2021-01-26 | Surmodics, Inc. | Delivery of hydrophobic active agents from hydrophilic polyether block amide copolymer surfaces |
US11931536B2 (en) * | 2017-07-26 | 2024-03-19 | Dk Medical Technology Co., Ltd. | Surface liquefied drug-coated balloon |
CN107998458B (zh) * | 2017-12-22 | 2021-02-19 | 鼎科医疗技术(苏州)有限公司 | 球囊药物涂层及药物球囊 |
CN109985280B (zh) * | 2017-12-29 | 2022-06-21 | 先健科技(深圳)有限公司 | 药物球囊及其制备方法 |
DE102018123050B4 (de) * | 2018-09-19 | 2020-08-13 | Alexander Ruebben | Wirkstoffbeschichtung für Ballons von Ballonkathetern |
JP2022521000A (ja) | 2019-02-22 | 2022-04-04 | ウロトロニック・インコーポレイテッド | 体腔用薬物コーティングバルーンカテーテル |
DE102020101197A1 (de) | 2020-01-20 | 2021-07-22 | Charité - Universitätsmedizin Berlin | Medizinprodukt zur Arzneimittelabgabe mit verstärkter Wirkung |
US11717653B2 (en) | 2020-05-29 | 2023-08-08 | Medtronic Vascular, Inc. | Drug-coated angioplasty balloons |
CN115531055A (zh) * | 2020-10-22 | 2022-12-30 | 上海三友医疗器械股份有限公司 | 椎间融合器及其使用方法 |
WO2023054762A1 (ko) * | 2021-09-30 | 2023-04-06 | 경상국립대학교병원 | 생체 흡수성 혈관 스캐폴드과 약물 용출성 스텐트 삽입 후 발생한 관상동맥 재협착증의 치료 방법 |
CN114939226B (zh) * | 2022-07-25 | 2022-11-25 | 中南大学 | 应用于胰肠吻合术的胰酶灭活支架引流管及其制备方法 |
CN117883178A (zh) * | 2024-01-17 | 2024-04-16 | 天津市鹰泰利安康医疗科技有限责任公司 | 一种基于不可逆电穿孔的泡沫细胞消融装置及应用 |
Citations (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1992011890A1 (en) * | 1991-01-04 | 1992-07-23 | Medtronic, Inc. | Releasable coatings on balloon catheters |
WO1992015282A2 (en) * | 1991-02-28 | 1992-09-17 | Indiana University Foundation | Composition and method for delivery of drugs |
DE4225553C1 (de) * | 1992-08-03 | 1994-05-11 | Michael Dr Rudolf | Ballonkatheter |
US5320634A (en) * | 1990-07-03 | 1994-06-14 | Interventional Technologies, Inc. | Balloon catheter with seated cutting edges |
US5370614A (en) * | 1991-01-04 | 1994-12-06 | Medtronic, Inc. | Method for making a drug delivery balloon catheter |
US5571086A (en) * | 1992-11-02 | 1996-11-05 | Localmed, Inc. | Method and apparatus for sequentially performing multiple intraluminal procedures |
US5626562A (en) * | 1994-11-28 | 1997-05-06 | Devices For Vascular Intervention | Drug delivery catheter |
EP0829238A1 (de) * | 1996-09-13 | 1998-03-18 | Interventional Technologies Inc | Vorrichtung zum Einscheiden und Aufdehnen von Bluttgefässen, mit einem sich verjüngenden Ballon |
US5792158A (en) * | 1995-11-15 | 1998-08-11 | Lary; Banning Gray | University dilator with expandable incisor |
WO2000044414A1 (en) * | 1999-01-28 | 2000-08-03 | Union Carbide Chemicals & Plastics Technology Corporation | Lubricious medical devices |
WO2000045744A1 (en) * | 1999-02-03 | 2000-08-10 | Boston Scientific Limited | Surface protection method for stents and balloon catheters for drug delivery |
US6306151B1 (en) * | 1998-03-31 | 2001-10-23 | Interventional Technologies Inc. | Balloon with reciprocating stent incisor |
US20020123505A1 (en) * | 1998-09-24 | 2002-09-05 | Mollison Karl W. | Medical devices containing rapamycin analogs |
Family Cites Families (352)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4101984A (en) | 1975-05-09 | 1978-07-25 | Macgregor David C | Cardiovascular prosthetic devices and implants with porous systems |
US4247352A (en) | 1976-11-29 | 1981-01-27 | North American Philips Corporation | Method of bonding crystal layers to insulating substrates |
DE2721752C2 (de) | 1977-05-13 | 1983-12-29 | Siemens AG, 1000 Berlin und 8000 München | In einen menschlichen oder tierischen Körper implantierbares Gerät zur Infusion einer medizinischen Flüssigkeit |
PL114463B2 (en) | 1978-12-20 | 1981-01-31 | Zaklad Aparatury Spawalniczej | Punching device in particular for boiler heads |
DE2909439A1 (de) | 1979-03-08 | 1980-09-18 | Schering Ag | Neue nichtionische roentgenkontrastmittel |
US4479795A (en) | 1979-06-29 | 1984-10-30 | The Procter & Gamble Company | Antimicrobial polymer compositions |
US4343788A (en) | 1979-06-29 | 1982-08-10 | The Procter & Gamble Company | Antimicrobial polymer compositions |
US4305926A (en) | 1979-09-13 | 1981-12-15 | Johannes Everse | Immobilization of Streptokinase |
IE51564B1 (en) | 1980-03-27 | 1987-01-21 | Nat Res Dev | Antimicrobial surgical implants |
JPS5881601A (ja) | 1981-11-11 | 1983-05-17 | 毛利 正巳 | ずれ落ちないガ−タ付靴下 |
US4502159A (en) | 1982-08-12 | 1985-03-05 | Shiley Incorporated | Tubular prostheses prepared from pericardial tissue |
US4769013A (en) | 1982-09-13 | 1988-09-06 | Hydromer, Inc. | Bio-effecting medical material and device |
FR2540128B1 (fr) | 1983-01-27 | 1986-02-21 | Rhone Poulenc Spec Chim | Compositions organopolysiloxaniques contenant des polyacyloxysilanes et durcissant tres rapidement en elastomeres en presence d'accelerateur du type hydroxyde metallique |
US4573476A (en) | 1983-11-14 | 1986-03-04 | Ruiz Oscar F | Angiographic catheter |
US5197977A (en) | 1984-01-30 | 1993-03-30 | Meadox Medicals, Inc. | Drug delivery collagen-impregnated synthetic vascular graft |
US5108424A (en) | 1984-01-30 | 1992-04-28 | Meadox Medicals, Inc. | Collagen-impregnated dacron graft |
US5456663A (en) | 1984-05-25 | 1995-10-10 | Lemelson; Jerome H. | Drugs and methods for treating diseases |
US4879135A (en) | 1984-07-23 | 1989-11-07 | University Of Medicine And Dentistry Of New Jersey | Drug bonded prosthesis and process for producing same |
GB8422876D0 (en) | 1984-09-11 | 1984-10-17 | Secr Defence | Silicon implant devices |
US4677143A (en) | 1984-10-01 | 1987-06-30 | Baxter Travenol Laboratories, Inc. | Antimicrobial compositions |
WO1986007541A1 (en) | 1985-06-19 | 1986-12-31 | Yasushi Zyo | Composition which can impart antithrombotic ability and medical apparatus to be in contact with blood |
SE8504501D0 (sv) * | 1985-09-30 | 1985-09-30 | Astra Meditec Ab | Method of forming an improved hydrophilic coating on a polymer surface |
US4733665C2 (en) | 1985-11-07 | 2002-01-29 | Expandable Grafts Partnership | Expandable intraluminal graft and method and apparatus for implanting an expandable intraluminal graft |
US4917686A (en) | 1985-12-16 | 1990-04-17 | Colorado Biomedical, Inc. | Antimicrobial device and method |
US6051405A (en) | 1986-09-24 | 2000-04-18 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Constructs encoding recombinant antibody-toxin fusion proteins |
US5059211A (en) | 1987-06-25 | 1991-10-22 | Duke University | Absorbable vascular stent |
US4909799A (en) | 1987-09-18 | 1990-03-20 | Olav Thulesius | Methods for preventing thrombosis; and surgical implant having reduced platelet deposition characteristics |
US5098977A (en) | 1987-09-23 | 1992-03-24 | Board Of Regents, The University Of Texas System | Methods and compositions for providing articles having improved biocompatability characteristics |
US4886062A (en) | 1987-10-19 | 1989-12-12 | Medtronic, Inc. | Intravascular radially expandable stent and method of implant |
US5019601A (en) | 1987-12-29 | 1991-05-28 | Cuno, Incorporated | Elastomeric composition containing therapeutic agents and articles manufactured therefrom |
US5019096A (en) | 1988-02-11 | 1991-05-28 | Trustees Of Columbia University In The City Of New York | Infection-resistant compositions, medical devices and surfaces and methods for preparing and using same |
US5157049A (en) | 1988-03-07 | 1992-10-20 | The United States Of America As Represented By The Department Of Health & Human Services | Method of treating cancers sensitive to treatment with water soluble derivatives of taxol |
US4950256A (en) | 1988-04-07 | 1990-08-21 | Luther Medical Products, Inc. | Non-thrombogenic intravascular time release catheter |
US4994047A (en) | 1988-05-06 | 1991-02-19 | Menlo Care, Inc. | Multi-layer cannula structure |
US5770198A (en) | 1988-05-18 | 1998-06-23 | The Research Foundation Of The State Of New York | Platelet-specific chimeric 7E3 immunoglobulin |
US5182317A (en) | 1988-06-08 | 1993-01-26 | Cardiopulmonics, Inc. | Multifunctional thrombo-resistant coatings and methods of manufacture |
US5019393A (en) | 1988-08-03 | 1991-05-28 | New England Deaconess Hospital Corporation | Biocompatible substance with thromboresistance |
US5019090A (en) | 1988-09-01 | 1991-05-28 | Corvita Corporation | Radially expandable endoprosthesis and the like |
US5053048A (en) | 1988-09-22 | 1991-10-01 | Cordis Corporation | Thromboresistant coating |
US5298255A (en) | 1988-10-28 | 1994-03-29 | Terumo Kabushiki Kaisha | Antithrombic medical material, artificial internal organ, and method for production of antithrombic medical material |
US5165952A (en) | 1989-01-18 | 1992-11-24 | Becton, Dickinson And Company | Anti-infective and antithrombogenic medical articles and method for their preparation |
US4925668A (en) | 1989-01-18 | 1990-05-15 | Becton, Dickinson And Company | Anti-infective and lubricious medical articles and method for their preparation |
US6146358A (en) | 1989-03-14 | 2000-11-14 | Cordis Corporation | Method and apparatus for delivery of therapeutic agent |
US4907643A (en) * | 1989-03-22 | 1990-03-13 | C F Braun Inc. | Combined heat exchanger system such as for ammonia synthesis reactor effluent |
US5004461A (en) | 1989-03-23 | 1991-04-02 | Wilson Joseph E | Methods for rendering plastics thromboresistant and product |
US5147302A (en) | 1989-04-21 | 1992-09-15 | Scimed Life Systems, Inc. | Method of shaping a balloon of a balloon catheter |
US5019604A (en) * | 1989-04-26 | 1991-05-28 | Lemole Gerald M | Protective gel composition |
CA2031520A1 (en) | 1989-04-28 | 1990-10-29 | Thomas P. Fondy | Cytochalasin compositions and therapeutic methods |
US5051257A (en) | 1989-05-09 | 1991-09-24 | Pietronigro Dennis D | Antineoplastic solution and method for treating neoplasms |
WO1990013332A1 (en) | 1989-05-11 | 1990-11-15 | Cedars-Sinai Medical Center | Stent with sustained drug delivery |
US5049131A (en) | 1989-05-31 | 1991-09-17 | Ashridge Ag | Balloon catheter |
US4997643A (en) | 1989-07-12 | 1991-03-05 | Union Carbide Chemicals And Plastics Company Inc. | Polymeric salt delivery systems |
US5318587A (en) | 1989-08-25 | 1994-06-07 | C. R. Bard, Inc. | Pleated balloon dilatation catheter and method of use |
US5232685A (en) | 1989-11-03 | 1993-08-03 | Schering Aktiengesellschaft | Nonionic x-ray contrast medium with high iodine content |
US5067491A (en) | 1989-12-08 | 1991-11-26 | Becton, Dickinson And Company | Barrier coating on blood contacting devices |
US5059166A (en) | 1989-12-11 | 1991-10-22 | Medical Innovative Technologies R & D Limited Partnership | Intra-arterial stent with the capability to inhibit intimal hyperplasia |
US5135516A (en) | 1989-12-15 | 1992-08-04 | Boston Scientific Corporation | Lubricious antithrombogenic catheters, guidewires and coatings |
US5304121A (en) | 1990-12-28 | 1994-04-19 | Boston Scientific Corporation | Drug delivery system making use of a hydrogel polymer coating |
US5843089A (en) | 1990-12-28 | 1998-12-01 | Boston Scientific Corporation | Stent lining |
US5674192A (en) | 1990-12-28 | 1997-10-07 | Boston Scientific Corporation | Drug delivery |
EP0441516B1 (de) | 1990-02-08 | 1995-03-29 | Howmedica Inc. | Aufblasbarer Dilatator |
DE69110787T2 (de) | 1990-02-28 | 1996-04-04 | Medtronic, Inc., Minneapolis, Minn. | Intraluminale prothese mit wirkstoffeluierung. |
WO1991017724A1 (en) | 1990-05-17 | 1991-11-28 | Harbor Medical Devices, Inc. | Medical device polymer |
US5092841A (en) | 1990-05-17 | 1992-03-03 | Wayne State University | Method for treating an arterial wall injured during angioplasty |
US5407683A (en) | 1990-06-01 | 1995-04-18 | Research Corporation Technologies, Inc. | Pharmaceutical solutions and emulsions containing taxol |
US5120322A (en) | 1990-06-13 | 1992-06-09 | Lathrotec, Inc. | Method and apparatus for treatment of fibrotic lesions |
US5196024A (en) | 1990-07-03 | 1993-03-23 | Cedars-Sinai Medical Center | Balloon catheter with cutting edge |
US5112457A (en) | 1990-07-23 | 1992-05-12 | Case Western Reserve University | Process for producing hydroxylated plasma-polymerized films and the use of the films for enhancing the compatiblity of biomedical implants |
US5455040A (en) | 1990-07-26 | 1995-10-03 | Case Western Reserve University | Anticoagulant plasma polymer-modified substrate |
US5163952A (en) | 1990-09-14 | 1992-11-17 | Michael Froix | Expandable polymeric stent with memory and delivery apparatus and method |
US5222971A (en) | 1990-10-09 | 1993-06-29 | Scimed Life Systems, Inc. | Temporary stent and methods for use and manufacture |
US5244654A (en) | 1990-11-08 | 1993-09-14 | Cordis Corporation | Radiofrequency plasma biocompatibility treatment of inside surfaces of medical tubing and the like |
US6524274B1 (en) | 1990-12-28 | 2003-02-25 | Scimed Life Systems, Inc. | Triggered release hydrogel drug delivery system |
CA2098984C (en) | 1990-12-28 | 2002-03-05 | Ronald Sahatjian | Drug delivery system |
WO1992011895A1 (en) | 1990-12-28 | 1992-07-23 | Boston Scientific Corporation | Balloon drug delivery system |
US5893840A (en) | 1991-01-04 | 1999-04-13 | Medtronic, Inc. | Releasable microcapsules on balloon catheters |
WO1992012717A2 (en) | 1991-01-15 | 1992-08-06 | A composition containing a tetracycline and use for inhibiting angiogenesis | |
US5762638A (en) | 1991-02-27 | 1998-06-09 | Shikani; Alain H. | Anti-infective and anti-inflammatory releasing systems for medical devices |
US5344411A (en) | 1991-02-27 | 1994-09-06 | Leonard Bloom | Method and device for inhibiting HIV, hepatitis B and other viruses and germs when using a catheter in a medical environment |
GB2254345B (en) | 1991-03-28 | 1995-06-14 | Grace W R & Co | Creping aid |
DE4115950A1 (de) | 1991-05-16 | 1992-11-19 | Herberts Gmbh | Fluessige gemische von photoinitiatoren, verfahren zu deren herstellung und deren verwendung |
NL9101159A (nl) | 1991-07-03 | 1993-02-01 | Industrial Res Bv | Vormvast te maken uitzetbare ring, cylinder of huls. |
US5356433A (en) | 1991-08-13 | 1994-10-18 | Cordis Corporation | Biocompatible metal surfaces |
SE9102778D0 (sv) | 1991-09-25 | 1991-09-25 | Siemens Elema Ab | Implanterbar medicinsk anordning |
US6515009B1 (en) | 1991-09-27 | 2003-02-04 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
US5811447A (en) | 1993-01-28 | 1998-09-22 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
US5464450A (en) | 1991-10-04 | 1995-11-07 | Scimed Lifesystems Inc. | Biodegradable drug delivery vascular stent |
WO1993006792A1 (en) | 1991-10-04 | 1993-04-15 | Scimed Life Systems, Inc. | Biodegradable drug delivery vascular stent |
US5500013A (en) | 1991-10-04 | 1996-03-19 | Scimed Life Systems, Inc. | Biodegradable drug delivery vascular stent |
US5234457A (en) | 1991-10-09 | 1993-08-10 | Boston Scientific Corporation | Impregnated stent |
DE4135193C1 (de) | 1991-10-22 | 1993-03-11 | Schering Ag Berlin Und Bergkamen, 1000 Berlin, De | |
JP3093375B2 (ja) | 1991-11-01 | 2000-10-03 | 株式会社東海メディカルプロダクツ | 抗血栓性物質の固定化方法 |
US5264220A (en) | 1991-11-12 | 1993-11-23 | Long David M Jr | Method of extending the vascular dwell-time of particulate therapeutic and particulate diagnostic agents |
US5302397A (en) | 1991-11-19 | 1994-04-12 | Amsden Brian G | Polymer-based drug delivery system |
US5270047A (en) | 1991-11-21 | 1993-12-14 | Kauffman Raymond F | Local delivery of dipyridamole for the treatment of proliferative diseases |
AU3221993A (en) | 1991-11-27 | 1993-06-28 | Phanos Technologies, Inc. | Compounds, compositions and methods for binding bio-affecting substances to surface membranes of bio-particles |
JPH07502274A (ja) | 1991-12-10 | 1995-03-09 | ラシユ−プレスビタリアン−セントルークス・メデイカル・センター | 多薬剤耐性を低下させる方法および組成物 |
CA2086642C (en) | 1992-01-09 | 2004-06-15 | Randall E. Morris | Method of treating hyperproliferative vascular disease |
US5176626A (en) | 1992-01-15 | 1993-01-05 | Wilson-Cook Medical, Inc. | Indwelling stent |
US5605896A (en) | 1992-02-25 | 1997-02-25 | Recordati S.A., Chemical And Pharmaceutical Company | Bicyclic heterocyclic derivatives having α1 adrenergic and 5HT1A activities |
US5217493A (en) | 1992-03-11 | 1993-06-08 | Board Of Regents, The University Of Texas System | Antibacterial coated medical implants |
US5282823A (en) | 1992-03-19 | 1994-02-01 | Medtronic, Inc. | Intravascular radially expandable stent |
US5571166A (en) | 1992-03-19 | 1996-11-05 | Medtronic, Inc. | Method of making an intraluminal stent |
US5599352A (en) | 1992-03-19 | 1997-02-04 | Medtronic, Inc. | Method of making a drug eluting stent |
US5209799A (en) | 1992-04-17 | 1993-05-11 | Inverventional Technologies, Inc. | Method for manufacturing a folding balloon catheter |
US5288711A (en) | 1992-04-28 | 1994-02-22 | American Home Products Corporation | Method of treating hyperproliferative vascular disease |
US5383927A (en) | 1992-05-07 | 1995-01-24 | Intervascular Inc. | Non-thromogenic vascular prosthesis |
US5629008A (en) | 1992-06-02 | 1997-05-13 | C.R. Bard, Inc. | Method and device for long-term delivery of drugs |
US5383928A (en) | 1992-06-10 | 1995-01-24 | Emory University | Stent sheath for local drug delivery |
DE4222380A1 (de) | 1992-07-08 | 1994-01-13 | Ernst Peter Prof Dr M Strecker | In den Körper eines Patienten perkutan implantierbare Endoprothese |
JPH0663145A (ja) | 1992-08-19 | 1994-03-08 | Buaayu:Kk | 血管内投薬用バルーンカテーテル |
DK0752885T3 (da) | 1992-09-25 | 2003-11-03 | Neorx Corp | Terapeutisk inhibitor for celler i den glatte karmuskulatur |
US5578075B1 (en) | 1992-11-04 | 2000-02-08 | Daynke Res Inc | Minimally invasive bioactivated endoprosthesis for vessel repair |
US5449382A (en) | 1992-11-04 | 1995-09-12 | Dayton; Michael P. | Minimally invasive bioactivated endoprosthesis for vessel repair |
US5342348A (en) | 1992-12-04 | 1994-08-30 | Kaplan Aaron V | Method and device for treating and enlarging body lumens |
US5443458A (en) | 1992-12-22 | 1995-08-22 | Advanced Cardiovascular Systems, Inc. | Multilayered biodegradable stent and method of manufacture |
EP0604022A1 (de) | 1992-12-22 | 1994-06-29 | Advanced Cardiovascular Systems, Inc. | Mehrschichtiges resorbierbares Stent und Verfahren zu dessen Herstellung |
US5419760A (en) | 1993-01-08 | 1995-05-30 | Pdt Systems, Inc. | Medicament dispensing stent for prevention of restenosis of a blood vessel |
US5229172A (en) | 1993-01-19 | 1993-07-20 | Medtronic, Inc. | Modification of polymeric surface by graft polymerization |
US5981568A (en) | 1993-01-28 | 1999-11-09 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
EP1447098A3 (de) | 1993-01-28 | 2005-06-29 | Boston Scientific Limited | Therapeutische Inhibitoren der glatten Gefässmuskulaturzellen |
US6491938B2 (en) | 1993-05-13 | 2002-12-10 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
US5370613A (en) | 1993-02-11 | 1994-12-06 | Helmy; Ali M. | Catheter apparatus for delivering drugs to the penis |
EP0693924B2 (de) | 1993-02-22 | 2008-04-09 | Abraxis BioScience, Inc. | Verfahren für die in-vivo-verabreichung von biologischen substanzen und hierfür verwendbare zusammensetzungen |
US5916596A (en) | 1993-02-22 | 1999-06-29 | Vivorx Pharmaceuticals, Inc. | Protein stabilized pharmacologically active agents, methods for the preparation thereof and methods for the use thereof |
US5976534A (en) | 1993-02-25 | 1999-11-02 | Zymogenetics, Inc. | Inhibition of intimal hyperplasia using antibodies to PDGF receptors and heparin |
JPH08507715A (ja) | 1993-03-18 | 1996-08-20 | シーダーズ サイナイ メディカル センター | 生体人工部材のための薬剤導入性および放出性重合性コーティング |
US5534288A (en) | 1993-03-23 | 1996-07-09 | United States Surgical Corporation | Infection-resistant surgical devices and methods of making them |
US5607463A (en) | 1993-03-30 | 1997-03-04 | Medtronic, Inc. | Intravascular medical device |
US5985307A (en) | 1993-04-14 | 1999-11-16 | Emory University | Device and method for non-occlusive localized drug delivery |
WO1994023787A1 (en) | 1993-04-22 | 1994-10-27 | Rammler David H | Sampling balloon catheter |
US5464650A (en) | 1993-04-26 | 1995-11-07 | Medtronic, Inc. | Intravascular stent and method |
SE9301422D0 (sv) | 1993-04-28 | 1993-04-28 | Kabi Pharmacia Ab | Method and means for inhibiting posterior capsule opacification |
US5531715A (en) | 1993-05-12 | 1996-07-02 | Target Therapeutics, Inc. | Lubricious catheters |
CA2162587C (en) | 1993-05-13 | 2008-07-08 | Kunz, Lawrence Leroy | Therapeutic inhibitor of vascular smooth muscle cells |
US20030203976A1 (en) | 1993-07-19 | 2003-10-30 | William L. Hunter | Anti-angiogenic compositions and methods of use |
US5886026A (en) | 1993-07-19 | 1999-03-23 | Angiotech Pharmaceuticals Inc. | Anti-angiogenic compositions and methods of use |
KR101222904B1 (ko) | 1993-07-19 | 2013-01-17 | 안지오테크 파마슈티칼즈, 인코포레이티드 | 항맥관형성 조성물, 당해 조성물로 피복된 스텐트 및 당해 스텐트의 제조방법 |
ES2255477T5 (es) | 1993-07-29 | 2010-04-08 | The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Uso de paclitaxel y sus derivados en la fabricacion de un medicamento para el tratamiento de reestenosis. |
US5567495A (en) | 1993-08-06 | 1996-10-22 | The Trustees Of Columbia University In The City Of New York | Infection resistant medical devices |
DE69429670T2 (de) | 1993-08-23 | 2002-08-22 | Boston Scientific Corp., Natick | Verbesserter ballonkatheter |
US5746745A (en) | 1993-08-23 | 1998-05-05 | Boston Scientific Corporation | Balloon catheter |
US5380299A (en) | 1993-08-30 | 1995-01-10 | Med Institute, Inc. | Thrombolytic treated intravascular medical device |
US5738901A (en) | 1993-09-20 | 1998-04-14 | Scimed Life Systems, Inc. | Catheter balloon with retraction coating |
US5496276A (en) | 1993-09-20 | 1996-03-05 | Scimed Life Systems, Inc. | Catheter balloon with retraction coating |
WO1996014895A1 (en) * | 1994-11-14 | 1996-05-23 | Scimed Life Systems, Inc. | Catheter balloon with retraction coating |
TW406020B (en) | 1993-09-29 | 2000-09-21 | Bristol Myers Squibb Co | Stabilized pharmaceutical composition and its method for preparation and stabilizing solvent |
US5531716A (en) | 1993-09-29 | 1996-07-02 | Hercules Incorporated | Medical devices subject to triggered disintegration |
DE4334272C2 (de) | 1993-10-07 | 1996-07-18 | Stemberger Axel Dr | Beschichtung für Biomaterial und seine Verwendung |
US5457113A (en) | 1993-10-15 | 1995-10-10 | Eli Lilly And Company | Methods for inhibiting vascular smooth muscle cell proliferation and restinosis |
US5350361A (en) | 1993-11-10 | 1994-09-27 | Medtronic, Inc. | Tri-fold balloon for dilatation catheter and related method |
US5454886A (en) | 1993-11-18 | 1995-10-03 | Westaim Technologies Inc. | Process of activating anti-microbial materials |
DE4341478C2 (de) | 1993-12-02 | 1998-10-08 | Max Delbrueck Centrum | Mittel zur Antitumortherapie |
ATE354377T1 (de) | 1993-12-02 | 2007-03-15 | Max Delbrueck Centrum | Antitumormittel, enthaltend ein zytostatikum und ein kontrastmittel |
US5397307A (en) | 1993-12-07 | 1995-03-14 | Schneider (Usa) Inc. | Drug delivery PTCA catheter and method for drug delivery |
JP3333211B2 (ja) | 1994-01-26 | 2002-10-15 | レイリー,マーク・エイ | 骨の治療に関する外科的方法で使用される、改良に係る拡張可能な装置 |
DE4408768C1 (de) | 1994-03-15 | 1995-05-04 | Siemens Ag | Verfahren zur Filterung einer digitalen Wertefolge mit verbessertem Rauschverhalten und Schaltungsanordnung zur Durchführung des Verfahrens |
US5510330A (en) | 1994-03-25 | 1996-04-23 | Boehringer Mannheim Gmbh | Combinations of thrombolytically active proteins and non-heparin anticoagulants, and uses thereof. |
DE4412055C1 (de) | 1994-04-07 | 1995-05-18 | Siemens Ag | CMOS-Abschlußwiderstandsschaltung |
US5456666A (en) | 1994-04-26 | 1995-10-10 | Boston Scientific Corp | Medical balloon folding into predetermined shapes and method |
US5554181A (en) | 1994-05-04 | 1996-09-10 | Regents Of The University Of Minnesota | Stent |
JP3631777B2 (ja) | 1994-06-03 | 2005-03-23 | テルモ株式会社 | 薬剤投与カテーテル |
US6123715A (en) | 1994-07-08 | 2000-09-26 | Amplatz; Curtis | Method of forming medical devices; intravascular occlusion devices |
US5649977A (en) | 1994-09-22 | 1997-07-22 | Advanced Cardiovascular Systems, Inc. | Metal reinforced polymer stent |
EP1181904B1 (de) | 1994-10-17 | 2009-06-24 | Kabushikikaisha Igaki Iryo Sekkei | Medikamentenfreisetzender Stent |
US5643580A (en) | 1994-10-17 | 1997-07-01 | Surface Genesis, Inc. | Biocompatible coating, medical device using the same and methods |
DE4446694A1 (de) | 1994-12-09 | 1996-06-13 | Schering Ag | Verwendung von Zusätzen zu Kontrastmitteln zur Verbesserung der Bildgebung |
CA2163837C (en) | 1994-12-13 | 1999-07-20 | Robert K. Perrone | Crystalline paclitaxel hydrates |
US5569198A (en) | 1995-01-23 | 1996-10-29 | Cortrak Medical Inc. | Microporous catheter |
US6017577A (en) | 1995-02-01 | 2000-01-25 | Schneider (Usa) Inc. | Slippery, tenaciously adhering hydrophilic polyurethane hydrogel coatings, coated polymer substrate materials, and coated medical devices |
DE69625799T2 (de) | 1995-02-01 | 2003-10-23 | Schneider (Usa) Inc., Plymouth | Verfahren zur hydrophilisierung von hydrophoben polymeren |
US5599576A (en) | 1995-02-06 | 1997-02-04 | Surface Solutions Laboratories, Inc. | Medical apparatus with scratch-resistant coating and method of making same |
DE19505155A1 (de) | 1995-02-16 | 1996-08-22 | Magna Zippex Autotechnik Gmbh | Verfahren zum Herstellen eines Auskleidungsteiles aus Kunststoff und ein insbesonders nach diesem Verfahren hergestelltes Auskleidungsteil |
US6558798B2 (en) | 1995-02-22 | 2003-05-06 | Scimed Life Systems, Inc. | Hydrophilic coating and substrates coated therewith having enhanced durability and lubricity |
US5571523A (en) | 1995-03-09 | 1996-11-05 | President And Fellows Of Harvard College | Antioxidant-induced apoptosis in vascular smooth muscle cells |
US5681846A (en) | 1995-03-17 | 1997-10-28 | Board Of Regents, The University Of Texas System | Extended stability formulations for paclitaxel |
US5605696A (en) | 1995-03-30 | 1997-02-25 | Advanced Cardiovascular Systems, Inc. | Drug loaded polymeric material and method of manufacture |
DE19514104C2 (de) | 1995-04-13 | 1997-05-28 | Behringwerke Ag | Beschichtung für in den Blutstrom oder in das Gewebe des menschlichen Körpers einbringbares Biomaterial |
US5624704A (en) | 1995-04-24 | 1997-04-29 | Baylor College Of Medicine | Antimicrobial impregnated catheters and other medical implants and method for impregnating catheters and other medical implants with an antimicrobial agent |
IL113926A (en) | 1995-05-31 | 2000-06-01 | Korenstein Rafi | Contrast medium with improved patient's tolerance thereto and its use |
US5820607A (en) | 1995-06-05 | 1998-10-13 | Board Of Regents, University Of Texas Systems | Multipurpose anti-microbial silastic sheath system for the prevention of device-related infections |
US7611533B2 (en) | 1995-06-07 | 2009-11-03 | Cook Incorporated | Coated implantable medical device |
US5772640A (en) | 1996-01-05 | 1998-06-30 | The Trustees Of Columbia University Of The City Of New York | Triclosan-containing medical devices |
US5820917A (en) | 1995-06-07 | 1998-10-13 | Medtronic, Inc. | Blood-contacting medical device and method |
US5609629A (en) | 1995-06-07 | 1997-03-11 | Med Institute, Inc. | Coated implantable medical device |
AU716005B2 (en) | 1995-06-07 | 2000-02-17 | Cook Medical Technologies Llc | Implantable medical device |
US6774278B1 (en) | 1995-06-07 | 2004-08-10 | Cook Incorporated | Coated implantable medical device |
US7550005B2 (en) | 1995-06-07 | 2009-06-23 | Cook Incorporated | Coated implantable medical device |
DE69623592T2 (de) | 1995-06-29 | 2003-05-15 | Macrochem Corp., Lexington | Lipophile und ampiphile filmbildende polymerzusammensetzungen und deren verwendung in systemen zur topischen abgabe von agenzien und verfahren zur abgabe von agenzien an die haut |
US5607475A (en) | 1995-08-22 | 1997-03-04 | Medtronic, Inc. | Biocompatible medical article and method |
ES2153984T3 (es) | 1995-11-08 | 2001-03-16 | Scimed Life Systems Inc | Procedimiento de formacion de balon mediante estrechamiento por estirado en frio. |
AU2150497A (en) | 1996-01-25 | 1997-08-20 | Schering Aktiengesellschaft | Improved concentrated injection and infusion solutions for intravenous adminis tration |
US6441025B2 (en) | 1996-03-12 | 2002-08-27 | Pg-Txl Company, L.P. | Water soluble paclitaxel derivatives |
HU226646B1 (en) | 1996-03-12 | 2009-05-28 | Pg Txl Company | Water soluble pharmaceutical compositions containing taxane derivatives |
US6071285A (en) | 1996-03-25 | 2000-06-06 | Lashinski; Robert D. | Rapid exchange folded balloon catheter and stent delivery system |
US5681522A (en) | 1996-04-01 | 1997-10-28 | Schneider (Usa) Inc. | Method and apparatus for annealing angioplasty balloons to improve re-wrappability thereof |
US5684051A (en) * | 1996-04-24 | 1997-11-04 | Hercules Incorporated | Medical devices with improved elastic response |
JP2000509623A (ja) | 1996-05-03 | 2000-08-02 | イーメッド コーポレイション | 冠状動脈のステントの配置と薬剤の部分的投与の組み合わせ |
AU716764B2 (en) | 1996-06-04 | 2000-03-09 | Cook Incorporated | Implantable medical device |
US20040068241A1 (en) | 1996-06-04 | 2004-04-08 | Fischer Frank J. | Implantable medical device |
DE69722720T2 (de) | 1996-07-24 | 2004-05-13 | Cordis Corp., Miami Lakes | Ballonkatheter und Methode zur Anwendung |
US5954740A (en) | 1996-09-23 | 1999-09-21 | Boston Scientific Corporation | Catheter balloon having raised radial segments |
US5797935A (en) | 1996-09-26 | 1998-08-25 | Interventional Technologies Inc. | Balloon activated forced concentrators for incising stenotic segments |
IT1294967B1 (it) | 1996-10-09 | 1999-04-23 | Ist Farmacoterapico It Spa | Composizione immunogenica da tlp |
PL332820A1 (en) | 1996-10-21 | 1999-10-11 | Nycomed Imaging As | Improved contrast media |
US6197013B1 (en) | 1996-11-06 | 2001-03-06 | Setagon, Inc. | Method and apparatus for drug and gene delivery |
US5893867A (en) | 1996-11-06 | 1999-04-13 | Percusurge, Inc. | Stent positioning apparatus and method |
US6495579B1 (en) | 1996-12-02 | 2002-12-17 | Angiotech Pharmaceuticals, Inc. | Method for treating multiple sclerosis |
US6515016B2 (en) | 1996-12-02 | 2003-02-04 | Angiotech Pharmaceuticals, Inc. | Composition and methods of paclitaxel for treating psoriasis |
US6071616A (en) | 1996-12-05 | 2000-06-06 | Texas Instruments Incorporated | Opaque low reflecting coating aperture on glass |
US5980972A (en) | 1996-12-20 | 1999-11-09 | Schneider (Usa) Inc | Method of applying drug-release coatings |
US5871692A (en) | 1997-01-14 | 1999-02-16 | Steris Corporation | Method and apparatus for cleaning, decontaminating, and sterilizing catheters |
US5868719A (en) | 1997-01-15 | 1999-02-09 | Boston Scientific Corporation | Drug delivery balloon catheter device |
US6491619B1 (en) | 1997-01-31 | 2002-12-10 | Endologix, Inc | Radiation delivery catheters and dosimetry methods |
CA2278586C (en) | 1997-02-20 | 2009-09-22 | Cook Incorporated | Coated implantable medical device |
CA2285391A1 (en) * | 1997-03-27 | 1998-10-01 | Baker Norton Pharmaceuticals, Inc. | Methods and compositions for treatment of ovarian cancer |
EP0975340B2 (de) | 1997-03-31 | 2009-10-28 | Boston Scientific Limited | Verwendung von cytoskelettinhibitoren zur vorbeugung der restenose |
US6240616B1 (en) | 1997-04-15 | 2001-06-05 | Advanced Cardiovascular Systems, Inc. | Method of manufacturing a medicated porous metal prosthesis |
US6273913B1 (en) | 1997-04-18 | 2001-08-14 | Cordis Corporation | Modified stent useful for delivery of drugs along stent strut |
GB9708240D0 (en) | 1997-04-23 | 1997-06-11 | Nycomed Imaging As | Improvements in or relating to contrast agents |
US20020039594A1 (en) | 1997-05-13 | 2002-04-04 | Evan C. Unger | Solid porous matrices and methods of making and using the same |
US6245760B1 (en) | 1997-05-28 | 2001-06-12 | Aventis Pharmaceuticals Products, Inc | Quinoline and quinoxaline compounds which inhibit platelet-derived growth factor and/or p56lck tyrosine kinases |
US6221467B1 (en) | 1997-06-03 | 2001-04-24 | Scimed Life Systems, Inc. | Coating gradient for lubricious coatings on balloon catheters |
DE19724796A1 (de) | 1997-06-06 | 1998-12-10 | Max Delbrueck Centrum | Mittel zur Antitumortherapie |
JPH1112160A (ja) | 1997-06-19 | 1999-01-19 | Nippon Schering Kk | 水溶性抗腫瘍薬含有エマルジョン型製剤およびキット |
DE69801438T2 (de) * | 1997-06-20 | 2002-05-16 | Coloplast A/S, Humlebaek | Hydrophile beschichtung und verfahren zu ihrer herstellung |
US6171232B1 (en) | 1997-06-26 | 2001-01-09 | Cordis Corporation | Method for targeting in vivo nitric oxide release |
US6214333B1 (en) | 1997-07-08 | 2001-04-10 | Texas Heart Institute | Vasoprotective recombinant adenovirus vector containing a human TFPI gene |
WO1999008729A1 (en) | 1997-08-13 | 1999-02-25 | Boston Scientific Limited | Loading and release of water-insoluble drugs |
US6306166B1 (en) | 1997-08-13 | 2001-10-23 | Scimed Life Systems, Inc. | Loading and release of water-insoluble drugs |
US5921952A (en) | 1997-08-14 | 1999-07-13 | Boston Scientific Corporation | Drainage catheter delivery system |
US6248100B1 (en) | 1997-08-14 | 2001-06-19 | Scimed Life Systems, Inc. | Drainage catheter delivery system |
KR20010023028A (ko) | 1997-08-20 | 2001-03-26 | 맥슨 시스템스 아이엔시. (런던) 엘티디. | 전자식 디렉토리의 저장된 엔트리 위치지정 방법 및 통신 장치 |
AU8877098A (en) | 1997-09-05 | 1999-03-29 | Nycomed Imaging As | Polymer particles made of polyvinyl alcohol and comprising contrast agent for chemoembolization |
US6284333B1 (en) | 1997-09-10 | 2001-09-04 | Scimed Life Systems, Inc. | Medical devices made from polymer blends containing low melting temperature liquid crystal polymers |
US5917772A (en) | 1997-09-16 | 1999-06-29 | Micron Technology, Inc. | Data input circuit for eliminating idle cycles in a memory device |
WO1999013916A2 (en) | 1997-09-18 | 1999-03-25 | Nycomed Imaging As | Methods and compositions for medical imaging |
US7445792B2 (en) | 2003-03-10 | 2008-11-04 | Abbott Laboratories | Medical device having a hydration inhibitor |
WO1999016500A2 (en) | 1997-10-01 | 1999-04-08 | Medtronic Ave, Inc. | Drug delivery and gene therapy delivery system |
US6309420B1 (en) | 1997-10-14 | 2001-10-30 | Parallax Medical, Inc. | Enhanced visibility materials for implantation in hard tissue |
DK1023090T3 (da) | 1997-10-15 | 2003-03-31 | Sherwood Serv Ag | Smøremiddelbelægning til medicinske anordninger |
US6273908B1 (en) | 1997-10-24 | 2001-08-14 | Robert Ndondo-Lay | Stents |
JP3170581B2 (ja) * | 1997-10-29 | 2001-05-28 | 株式会社八光メディカル | 薬剤徐放性カテーテルとその製造方法 |
DE69828615T2 (de) | 1997-10-31 | 2005-12-01 | Walter Reed Army Institute Of Research | Verwendung von inhibitoren der komplementaktivierung zur herstellung eines medikaments zur inhibierung von nebenwirkungen von pharmazeutischen zusammensetzungen, die amphiphile träger oder wirkstoffträger moleküle enthalten |
US6013055A (en) | 1997-11-13 | 2000-01-11 | Boston Scientific Corporation | Catheter balloon having selected folding characteristics |
CA2310232A1 (en) | 1997-11-17 | 1999-05-27 | Ronald H. Lane | Methods for preventing restenosis using tocotrienols |
US6485514B1 (en) | 1997-12-12 | 2002-11-26 | Supergen, Inc. | Local delivery of therapeutic agents |
US6123923A (en) | 1997-12-18 | 2000-09-26 | Imarx Pharmaceutical Corp. | Optoacoustic contrast agents and methods for their use |
US6203487B1 (en) | 1997-12-31 | 2001-03-20 | Thomas Jefferson University | Use of magnetic particles in the focal delivery of cells |
CN1224622A (zh) | 1998-01-24 | 1999-08-04 | 张尚权 | 肿瘤靶向造影剂 |
US6221425B1 (en) | 1998-01-30 | 2001-04-24 | Advanced Cardiovascular Systems, Inc. | Lubricious hydrophilic coating for an intracorporeal medical device |
US6033380A (en) | 1998-02-13 | 2000-03-07 | Cordis Corporation | Six-pleated catheter balloon and device for forming same |
US6623521B2 (en) | 1998-02-17 | 2003-09-23 | Md3, Inc. | Expandable stent with sliding and locking radial elements |
IL131217A0 (en) | 1998-03-10 | 2001-01-28 | Napro Biotherapeutics Inc | Novel methods and compositions for delivery of taxanes |
US5997162A (en) | 1998-03-13 | 1999-12-07 | Osram Sylvania Inc. | Horizontal HID vehicle headlamp with magnetic deflection |
WO1999049908A1 (en) | 1998-03-31 | 1999-10-07 | University Of Cincinnati | Temperature controlled solute delivery system |
US6364856B1 (en) * | 1998-04-14 | 2002-04-02 | Boston Scientific Corporation | Medical device with sponge coating for controlled drug release |
US8029561B1 (en) * | 2000-05-12 | 2011-10-04 | Cordis Corporation | Drug combination useful for prevention of restenosis |
AU760408B2 (en) | 1998-04-27 | 2003-05-15 | Surmodics, Inc. | Bioactive agent release coating |
US6296655B1 (en) | 1998-04-27 | 2001-10-02 | Advanced Cardiovascular Systems, Inc. | Catheter balloon with biased multiple wings |
AU764958B2 (en) | 1998-05-15 | 2003-09-04 | X Technologies, Inc. | Enhanced balloon dilatation system |
EP1077686B1 (de) | 1998-05-15 | 2008-08-06 | NASA/Johnson Space Center | Mikrokapseln mit extern ausgelöster öffnung |
US6206283B1 (en) | 1998-12-23 | 2001-03-27 | At&T Corp. | Method and apparatus for transferring money via a telephone call |
US6280411B1 (en) * | 1998-05-18 | 2001-08-28 | Scimed Life Systems, Inc. | Localized delivery of drug agents |
US6339039B1 (en) | 1998-06-12 | 2002-01-15 | Jerker Porath | Hydrogel product for adsorption purposes |
ATE211931T1 (de) | 1998-06-26 | 2002-02-15 | Quanam Medical Corp | Topoisomerase inhibitoren zur restenose- prevention |
US6203812B1 (en) | 1998-06-29 | 2001-03-20 | Hydromer, Inc. | Hydrophilic polymer blends used to prevent cow skin infections |
US6369039B1 (en) | 1998-06-30 | 2002-04-09 | Scimed Life Sytems, Inc. | High efficiency local drug delivery |
WO2000006152A1 (en) | 1998-07-30 | 2000-02-10 | Novopharm Biotech, Inc. | Pharmaceutically acceptable composition comprising an aqueous solution of paclitaxel and albumin |
AU5333599A (en) | 1998-08-06 | 2000-02-28 | Cardeon Corporation | Aortic catheter with porous aortic arch balloon and methods for selective aorticperfusion |
US6013092A (en) | 1998-08-18 | 2000-01-11 | Baxter International Inc. | Folding of catheter-mounted balloons to facilitate non-rotational radial expansion of intraluminal devices |
CA2340652C (en) | 1998-08-20 | 2013-09-24 | Cook Incorporated | Coated implantable medical device comprising paclitaxel |
AU5687199A (en) | 1998-08-24 | 2000-03-14 | Global Vascular Concepts, Inc. | Use of anti-angiogenic agents for inhibiting vessel wall injury |
US6335029B1 (en) | 1998-08-28 | 2002-01-01 | Scimed Life Systems, Inc. | Polymeric coatings for controlled delivery of active agents |
CA2341507C (en) | 1998-08-28 | 2011-05-24 | William Guy Love | Porphyrin derivatives, their use in photodynamic therapy and medical devices containing them |
DE19840322A1 (de) | 1998-09-04 | 2000-03-09 | Bayer Ag | Pyrazol-carboxanilide |
US5922754A (en) | 1998-10-02 | 1999-07-13 | Abbott Laboratories | Pharmaceutical compositions containing paclitaxel |
US6017948A (en) | 1998-10-30 | 2000-01-25 | Supergen, Inc. | Water-miscible pharmaceutical compositions |
AUPP735398A0 (en) | 1998-11-26 | 1998-12-24 | Rothmans Of Pall Mall (Australia) Limited | Release device for a dispensing chute |
EP1135165A1 (de) | 1998-12-03 | 2001-09-26 | Boston Scientific Limited | Dilatator beschichtet mit arzneistoffkristallen |
US7780628B1 (en) | 1999-01-11 | 2010-08-24 | Angiodynamics, Inc. | Apparatus and methods for treating congestive heart disease |
CA2362883A1 (en) | 1999-02-12 | 2000-08-17 | Quanam Medical Corporation | Alkylating agents for treatment of cellular proliferation |
US6294192B1 (en) * | 1999-02-26 | 2001-09-25 | Lipocine, Inc. | Triglyceride-free compositions and methods for improved delivery of hydrophobic therapeutic agents |
US7919119B2 (en) | 1999-05-27 | 2011-04-05 | Acusphere, Inc. | Porous drug matrices and methods of manufacture thereof |
US6610317B2 (en) * | 1999-05-27 | 2003-08-26 | Acusphere, Inc. | Porous paclitaxel matrices and methods of manufacture thereof |
US6790228B2 (en) | 1999-12-23 | 2004-09-14 | Advanced Cardiovascular Systems, Inc. | Coating for implantable devices and a method of forming the same |
US6503954B1 (en) | 2000-03-31 | 2003-01-07 | Advanced Cardiovascular Systems, Inc. | Biocompatible carrier containing actinomycin D and a method of forming the same |
US6706892B1 (en) | 1999-09-07 | 2004-03-16 | Conjuchem, Inc. | Pulmonary delivery for bioconjugation |
US6203551B1 (en) | 1999-10-04 | 2001-03-20 | Advanced Cardiovascular Systems, Inc. | Chamber for applying therapeutic substances to an implant device |
US6682545B1 (en) | 1999-10-06 | 2004-01-27 | The Penn State Research Foundation | System and device for preventing restenosis in body vessels |
EP1221997B1 (de) | 1999-10-06 | 2007-11-28 | The Penn State Research Foundation | System und vorrichtung zur vermeidung von restenose in körpergefässen |
JP4613406B2 (ja) | 1999-11-05 | 2011-01-19 | 株式会社デンソー | 受光素子、距離測定装置及び距離・画像測定装置 |
US6254921B1 (en) | 1999-12-08 | 2001-07-03 | Surmodics, Inc. | Coating process and apparatus |
US6616591B1 (en) | 1999-12-08 | 2003-09-09 | Scimed Life Systems, Inc. | Radioactive compositions and methods of use thereof |
US6355058B1 (en) | 1999-12-30 | 2002-03-12 | Advanced Cardiovascular Systems, Inc. | Stent with radiopaque coating consisting of particles in a binder |
US6491617B1 (en) | 1999-12-30 | 2002-12-10 | St. Jude Medical, Inc. | Medical devices that resist restenosis |
US6899731B2 (en) | 1999-12-30 | 2005-05-31 | Boston Scientific Scimed, Inc. | Controlled delivery of therapeutic agents by insertable medical devices |
CA2395132A1 (en) * | 2000-01-05 | 2001-07-12 | Imarx Therapeutics, Inc. | Pharmaceutical formulations for the delivery of drugs having low aqueous solubility |
WO2001052772A1 (en) * | 2000-01-19 | 2001-07-26 | The Government Of The United States Of America, As Represented By The Secretary, Department Of Health_Human Servicesthe National Institutes Of Health | Method and apparatus for coating an endoprosthesis |
US6575888B2 (en) | 2000-01-25 | 2003-06-10 | Biosurface Engineering Technologies, Inc. | Bioabsorbable brachytherapy device |
EP1250166B1 (de) | 2000-01-25 | 2010-03-17 | Edwards Lifesciences Corporation | Freisetzungssysteme zur behandlung von restenose und anastomotischer intimaler hyperplasie |
US6562061B1 (en) | 2000-02-22 | 2003-05-13 | Scimed Life Systems, Inc. | Stent delivery balloon with securement structure |
AU2001247425A1 (en) | 2000-04-10 | 2001-10-23 | Advanced Cardiovascular Systems Inc. | Selectively coated stent delivery system and method of manufacture thereof |
US6599448B1 (en) | 2000-05-10 | 2003-07-29 | Hydromer, Inc. | Radio-opaque polymeric compositions |
US6585765B1 (en) | 2000-06-29 | 2003-07-01 | Advanced Cardiovascular Systems, Inc. | Implantable device having substances impregnated therein and a method of impregnating the same |
TWI257307B (en) | 2000-07-12 | 2006-07-01 | Orthologic Corp | Pharmaceutical composition for cardiac tissue repair |
KR100353326B1 (ko) | 2000-08-11 | 2002-09-18 | 삼성전자 주식회사 | 컴퓨터 주변기기의 절전장치 및 절전방법 |
US20020051730A1 (en) | 2000-09-29 | 2002-05-02 | Stanko Bodnar | Coated medical devices and sterilization thereof |
US7803149B2 (en) | 2002-07-12 | 2010-09-28 | Cook Incorporated | Coated medical device |
WO2003026718A1 (en) | 2000-10-31 | 2003-04-03 | Cook Incorporated | Coated implantable medical device |
JP2004533274A (ja) * | 2000-11-28 | 2004-11-04 | ボストン サイエンティフィック リミテッド | 送出マトリックスから治療剤を送出する方法及び装置 |
US6638246B1 (en) | 2000-11-28 | 2003-10-28 | Scimed Life Systems, Inc. | Medical device for delivery of a biologically active material to a lumen |
US20020103526A1 (en) | 2000-12-15 | 2002-08-01 | Tom Steinke | Protective coating for stent |
US6635082B1 (en) | 2000-12-29 | 2003-10-21 | Advanced Cardiovascular Systems Inc. | Radiopaque stent |
US6544223B1 (en) | 2001-01-05 | 2003-04-08 | Advanced Cardiovascular Systems, Inc. | Balloon catheter for delivering therapeutic agents |
US8277868B2 (en) | 2001-01-05 | 2012-10-02 | Abbott Cardiovascular Systems Inc. | Balloon catheter for delivering therapeutic agents |
US7179251B2 (en) | 2001-01-17 | 2007-02-20 | Boston Scientific Scimed, Inc. | Therapeutic delivery balloon |
DE50210591D1 (de) | 2001-02-16 | 2007-09-13 | Abbott Lab Vascular Entpr Ltd | Implantate mit fk506 zur restenosebehandlung und -prophylaxe |
WO2002066092A2 (en) | 2001-02-23 | 2002-08-29 | Angiogene Inc. | Drug eluting device for treating vascular diseases |
DE10115740A1 (de) | 2001-03-26 | 2002-10-02 | Ulrich Speck | Zubereitung für die Restenoseprophylaxe |
FR2823118B1 (fr) | 2001-04-04 | 2004-03-19 | Lavipharm Lab Inc | Nouvelle composition filmogene a usage topique et son utilisation pour la delivrance d'agents actifs |
TWI288654B (en) | 2001-05-17 | 2007-10-21 | Ind Tech Res Inst | Process for the purification of water-soluble non-ionic contrast agents |
EP1412014A4 (de) | 2001-06-14 | 2005-06-15 | Cook Inc | Endovaskulärer filter |
WO2003022264A1 (en) | 2001-09-13 | 2003-03-20 | Korea Institute Of Science And Technology | Paclitaxel mixed composition and water-in-oil type emulsion formulation for chemoembolization and preparation method thereof |
IN2014DN10834A (de) * | 2001-09-17 | 2015-09-04 | Psivida Inc | |
DE60238422D1 (de) | 2001-09-24 | 2011-01-05 | Boston Scient Ltd | Optimierte dosierung bei paclitaxelhaltigen stents |
AU2002343739A1 (en) | 2001-11-14 | 2003-05-26 | Medlogic Global Limited | Improved therapy for topical diseases |
DE60237915D1 (en) | 2001-12-03 | 2010-11-18 | Universitaetsklinikum Charite | Podophyllotoxine als antiproliferative mittel |
US20030144683A1 (en) | 2001-12-13 | 2003-07-31 | Avantec Vascular Corporation | Inflatable members having concentrated force regions |
US7186237B2 (en) | 2002-02-14 | 2007-03-06 | Avantec Vascular Corporation | Ballon catheter for creating a longitudinal channel in a lesion and method |
US7985234B2 (en) | 2002-02-27 | 2011-07-26 | Boston Scientific Scimed, Inc. | Medical device |
CN1159071C (zh) * | 2002-03-08 | 2004-07-28 | 清华大学 | 生物可降解的药物复合高分子支架材料的制备方法 |
EP1534355A1 (de) * | 2002-06-21 | 2005-06-01 | Genzyme Corporation | Silikon-mischungen und komposite für die medikamentenabgabe |
EP1536850B1 (de) | 2002-09-06 | 2016-08-10 | Abbott Laboratories | Medizinisches gerät mit einem hydratationsinhibitor |
DE10244847A1 (de) | 2002-09-20 | 2004-04-01 | Ulrich Prof. Dr. Speck | Medizinische Vorrichtung zur Arzneimittelabgabe |
US7060051B2 (en) | 2002-09-24 | 2006-06-13 | Scimed Life Systems, Inc. | Multi-balloon catheter with hydrogel coating |
CA2444781A1 (en) | 2002-10-17 | 2004-04-17 | Rolf C. Hagen Inc. | Topical gel matrix |
US7491234B2 (en) | 2002-12-03 | 2009-02-17 | Boston Scientific Scimed, Inc. | Medical devices for delivery of therapeutic agents |
US20040224003A1 (en) * | 2003-02-07 | 2004-11-11 | Schultz Robert K. | Drug formulations for coating medical devices |
WO2005027996A2 (en) | 2003-09-15 | 2005-03-31 | Atrium Medical Corporation | Application of a therapeutic substance to a tissue location using an expandable medical device |
US20050063926A1 (en) | 2003-09-23 | 2005-03-24 | Bathina Harinath B. | Film-forming compositions for protecting animal skin |
WO2005089855A1 (en) | 2004-03-19 | 2005-09-29 | Abbott Laboratories | Multiple drug delivery from a balloon and a prosthesis |
WO2005112570A2 (en) | 2004-05-12 | 2005-12-01 | Medtronic Vascular, Inc. | Drug-polymer coated stent |
US20060029720A1 (en) | 2004-08-03 | 2006-02-09 | Anastasia Panos | Methods and apparatus for injection coating a medical device |
CN101321806B (zh) | 2005-12-05 | 2011-01-26 | 日东电工株式会社 | 聚谷氨酸盐-氨基酸轭合物及方法 |
JP4892289B2 (ja) * | 2006-07-07 | 2012-03-07 | 株式会社日立製作所 | 複数のストレージ装置を含むストレージシステム |
WO2008011377A2 (en) | 2006-07-17 | 2008-01-24 | 3M Innovative Properties Company | Led package with converging extractor |
US8425459B2 (en) | 2006-11-20 | 2013-04-23 | Lutonix, Inc. | Medical device rapid drug releasing coatings comprising a therapeutic agent and a contrast agent |
US8414909B2 (en) | 2006-11-20 | 2013-04-09 | Lutonix, Inc. | Drug releasing coatings for medical devices |
US8414526B2 (en) | 2006-11-20 | 2013-04-09 | Lutonix, Inc. | Medical device rapid drug releasing coatings comprising oils, fatty acids, and/or lipids |
EP2322235A1 (de) | 2006-11-20 | 2011-05-18 | Lutonix, Inc. | Wirkstofffreisetzende Beschichtungen für medizinische Vorrichtungen |
US8414525B2 (en) | 2006-11-20 | 2013-04-09 | Lutonix, Inc. | Drug releasing coatings for medical devices |
-
2002
- 2002-09-20 DE DE2002144847 patent/DE10244847A1/de not_active Ceased
-
2003
- 2003-08-26 EP EP14199403.8A patent/EP2857050B1/de not_active Revoked
- 2003-08-26 CN CN200710141689XA patent/CN101134120B/zh not_active Expired - Lifetime
- 2003-08-26 JP JP2004538694A patent/JP2005538812A/ja not_active Withdrawn
- 2003-08-26 CN CNB038242745A patent/CN100349624C/zh not_active Expired - Lifetime
- 2003-08-26 EP EP18188713.4A patent/EP3424542A1/de active Pending
- 2003-08-26 BR BRPI0314854A patent/BRPI0314854B8/pt not_active IP Right Cessation
- 2003-08-26 DE DE50309589T patent/DE50309589D1/de not_active Expired - Lifetime
- 2003-08-26 RU RU2005111752A patent/RU2316358C2/ru active
- 2003-08-26 DE DE2003221514 patent/DE20321514U1/de not_active Ceased
- 2003-08-26 DK DK03750300T patent/DK1539266T3/da active
- 2003-08-26 BR BR0314854A patent/BR0314854A/pt active IP Right Grant
- 2003-08-26 EP EP14199379.0A patent/EP2857048B1/de not_active Revoked
- 2003-08-26 DE DE2003221606 patent/DE20321606U1/de not_active Expired - Lifetime
- 2003-08-26 EP EP10163581.1A patent/EP2216055B1/de not_active Expired - Lifetime
- 2003-08-26 MX MXPA05003041A patent/MXPA05003041A/es active IP Right Grant
- 2003-08-26 AU AU2003269690A patent/AU2003269690B2/en not_active Expired
- 2003-08-26 SI SI200331213T patent/SI1539266T1/sl unknown
- 2003-08-26 PL PL374330A patent/PL217416B1/pl unknown
- 2003-08-26 EP EP07017424.8A patent/EP1857127B1/de not_active Revoked
- 2003-08-26 KR KR1020057004653A patent/KR101123528B1/ko active IP Right Grant
- 2003-08-26 CA CA 2499053 patent/CA2499053C/en not_active Expired - Lifetime
- 2003-08-26 ES ES14199403.8T patent/ES2620496T3/es not_active Expired - Lifetime
- 2003-08-26 KR KR1020117022285A patent/KR101277416B1/ko active IP Right Grant
- 2003-08-26 EP EP10163587.8A patent/EP2216056B1/de not_active Expired - Lifetime
- 2003-08-26 ES ES03750300T patent/ES2300604T3/es not_active Expired - Lifetime
- 2003-08-26 PT PT03750300T patent/PT1539266E/pt unknown
- 2003-08-26 CN CN2007101416902A patent/CN101130112B/zh not_active Expired - Lifetime
- 2003-08-26 AT AT03750300T patent/ATE391520T1/de active
- 2003-08-26 EP EP14199392.3A patent/EP2857049B1/de not_active Revoked
- 2003-08-26 WO PCT/DE2003/002871 patent/WO2004028582A1/de active Search and Examination
- 2003-08-26 EP EP20030750300 patent/EP1539266B1/de not_active Revoked
- 2003-08-26 ES ES14199392.3T patent/ES2616521T3/es not_active Expired - Lifetime
- 2003-08-26 US US10/528,577 patent/US8257305B2/en active Active
- 2003-09-19 WO PCT/EP2003/010480 patent/WO2004028610A2/de active Application Filing
- 2003-09-19 AU AU2003270229A patent/AU2003270229A1/en not_active Abandoned
- 2003-09-19 JP JP2004538961A patent/JP4502812B2/ja not_active Expired - Fee Related
- 2003-09-19 EP EP03750586.4A patent/EP1539267B1/de not_active Expired - Lifetime
-
2005
- 2005-03-10 IL IL167356A patent/IL167356A/en active IP Right Grant
- 2005-03-17 ZA ZA2005/02274A patent/ZA200502274B/en unknown
-
2006
- 2006-02-15 HK HK06101902A patent/HK1081469A1/xx not_active IP Right Cessation
-
2008
- 2008-05-02 HK HK08104882.5A patent/HK1114798A1/xx not_active IP Right Cessation
- 2008-06-18 HK HK08106679.7A patent/HK1116100A1/xx not_active IP Right Cessation
- 2008-07-07 CY CY20081100705T patent/CY1112437T1/el unknown
- 2008-07-29 IL IL193114A patent/IL193114A/en active IP Right Grant
- 2008-11-18 AU AU2008246240A patent/AU2008246240B2/en not_active Expired
-
2010
- 2010-05-18 AU AU2010202002A patent/AU2010202002B2/en not_active Expired
- 2010-05-19 US US12/782,989 patent/US8439868B2/en not_active Expired - Lifetime
- 2010-07-09 JP JP2010156947A patent/JP6005899B2/ja not_active Expired - Lifetime
-
2011
- 2011-05-09 IL IL212778A patent/IL212778A/en active IP Right Grant
- 2011-05-09 IL IL212777A patent/IL212777A/en active IP Right Grant
-
2013
- 2013-04-19 US US13/866,547 patent/US9649476B2/en active Active
-
2014
- 2014-04-21 US US14/257,070 patent/US9216273B2/en not_active Expired - Lifetime
- 2014-04-21 US US14/257,064 patent/US9216272B2/en not_active Expired - Lifetime
- 2014-04-21 US US14/257,059 patent/US9302080B2/en not_active Expired - Fee Related
- 2014-08-22 JP JP2014169019A patent/JP6174535B2/ja not_active Expired - Lifetime
-
2015
- 2015-12-07 US US14/960,565 patent/US9687635B2/en not_active Expired - Lifetime
-
2016
- 2016-03-07 JP JP2016043521A patent/JP6309988B2/ja not_active Expired - Lifetime
-
2017
- 2017-05-19 JP JP2017099633A patent/JP6756664B2/ja not_active Expired - Lifetime
Patent Citations (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5320634A (en) * | 1990-07-03 | 1994-06-14 | Interventional Technologies, Inc. | Balloon catheter with seated cutting edges |
WO1992011890A1 (en) * | 1991-01-04 | 1992-07-23 | Medtronic, Inc. | Releasable coatings on balloon catheters |
US5370614A (en) * | 1991-01-04 | 1994-12-06 | Medtronic, Inc. | Method for making a drug delivery balloon catheter |
WO1992015282A2 (en) * | 1991-02-28 | 1992-09-17 | Indiana University Foundation | Composition and method for delivery of drugs |
DE4225553C1 (de) * | 1992-08-03 | 1994-05-11 | Michael Dr Rudolf | Ballonkatheter |
US5571086A (en) * | 1992-11-02 | 1996-11-05 | Localmed, Inc. | Method and apparatus for sequentially performing multiple intraluminal procedures |
US5626562A (en) * | 1994-11-28 | 1997-05-06 | Devices For Vascular Intervention | Drug delivery catheter |
US5792158A (en) * | 1995-11-15 | 1998-08-11 | Lary; Banning Gray | University dilator with expandable incisor |
EP0829238A1 (de) * | 1996-09-13 | 1998-03-18 | Interventional Technologies Inc | Vorrichtung zum Einscheiden und Aufdehnen von Bluttgefässen, mit einem sich verjüngenden Ballon |
US6306151B1 (en) * | 1998-03-31 | 2001-10-23 | Interventional Technologies Inc. | Balloon with reciprocating stent incisor |
US20020123505A1 (en) * | 1998-09-24 | 2002-09-05 | Mollison Karl W. | Medical devices containing rapamycin analogs |
WO2000044414A1 (en) * | 1999-01-28 | 2000-08-03 | Union Carbide Chemicals & Plastics Technology Corporation | Lubricious medical devices |
WO2000045744A1 (en) * | 1999-02-03 | 2000-08-10 | Boston Scientific Limited | Surface protection method for stents and balloon catheters for drug delivery |
Cited By (109)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7947015B2 (en) | 1999-01-25 | 2011-05-24 | Atrium Medical Corporation | Application of a therapeutic substance to a tissue location using an expandable medical device |
US9050442B2 (en) | 1999-01-25 | 2015-06-09 | Atrium Medical Corporation | Expandable fluoropolymer device for delivery of therapeutic agents and method of making |
US8389043B2 (en) | 2001-03-26 | 2013-03-05 | Bayer Pharma Aktiengesellschaft | Preparation for restenosis prevention |
US9066990B2 (en) | 2001-03-26 | 2015-06-30 | Bayer Intellectual Property Gmbh | Preparation for restenosis prevention |
US7750041B2 (en) | 2001-03-26 | 2010-07-06 | Bayer Schering Pharma Aktiengesellschaft | Preparation for the prophylaxis of restenosis |
US11571554B2 (en) | 2001-11-09 | 2023-02-07 | Angioscore, Inc. | Balloon catheter with non-deployable stent |
US10086178B2 (en) | 2001-11-09 | 2018-10-02 | Angioscore, Inc. | Balloon catheter with non-deployable stent |
US9375328B2 (en) | 2001-11-09 | 2016-06-28 | Angioscore, Inc. | Balloon catheter with non-deployable stent |
US7803149B2 (en) | 2002-07-12 | 2010-09-28 | Cook Incorporated | Coated medical device |
US8513429B2 (en) | 2002-08-23 | 2013-08-20 | Sloan-Kettering Insitute For Cancer Research | Synthesis of epothilones, intermediates thereto and analogues thereof |
US7759374B2 (en) | 2002-08-23 | 2010-07-20 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto and analogues thereof |
US7875638B2 (en) | 2002-08-23 | 2011-01-25 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto, analogues and uses thereof |
US8110590B2 (en) | 2002-08-23 | 2012-02-07 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto and analogues thereof |
US9302080B2 (en) | 2002-09-20 | 2016-04-05 | Bayer Intellectual Property Gmbh | Medical device for dispersing medicaments |
US9216272B2 (en) | 2002-09-20 | 2015-12-22 | Bayer Intellectual Property Gmbh | Medical device for dispersing medicaments |
US9216273B2 (en) | 2002-09-20 | 2015-12-22 | Bayer Intellectual Property Gmbh | Medical device for dispersing medicaments |
US8257305B2 (en) | 2002-09-20 | 2012-09-04 | Bayer Pharma Aktiengesellschaft | Medical device for dispensing medicaments |
US9649476B2 (en) | 2002-09-20 | 2017-05-16 | Bayer Intellectual Property Gmbh | Medical device for dispersing medicaments |
US9687635B2 (en) | 2002-09-20 | 2017-06-27 | Bayer Intellectual Property Gmbh | Medical device for dispersing medicaments |
US8080026B2 (en) | 2003-01-21 | 2011-12-20 | Angioscore, Inc. | Apparatus and methods for treating hardened vascular lesions |
US8721667B2 (en) | 2003-01-21 | 2014-05-13 | Angioscore, Inc. | Apparatus and methods for treating hardened vascular lesions |
US10722694B2 (en) | 2003-01-21 | 2020-07-28 | Angioscore, Inc. | Apparatus and methods for treating hardened vascular lesions |
US9962529B2 (en) | 2003-01-21 | 2018-05-08 | Angioscore, Inc. | Apparatus and methods for treating hardened vascular lesions |
US8454636B2 (en) | 2003-01-21 | 2013-06-04 | Angioscore, Inc. | Apparatus and methods for treating hardened vascular lesions |
US7572245B2 (en) | 2003-09-15 | 2009-08-11 | Atrium Medical Corporation | Application of a therapeutic substance to a tissue location using an expandable medical device |
US8021331B2 (en) | 2003-09-15 | 2011-09-20 | Atrium Medical Corporation | Method of coating a folded medical device |
US10869902B2 (en) | 2004-09-28 | 2020-12-22 | Atrium Medical Corporation | Cured gel and method of making |
US10814043B2 (en) | 2004-09-28 | 2020-10-27 | Atrium Medical Corporation | Cross-linked fatty acid-based biomaterials |
US10792312B2 (en) | 2004-09-28 | 2020-10-06 | Atrium Medical Corporation | Barrier layer |
US10772995B2 (en) | 2004-09-28 | 2020-09-15 | Atrium Medical Corporation | Cross-linked fatty acid-based biomaterials |
US11793912B2 (en) | 2004-09-28 | 2023-10-24 | Atrium Medical Corporation | Cross-linked fatty acid-based biomaterials |
US10342960B2 (en) | 2005-05-11 | 2019-07-09 | Angioscore, Inc. | Methods and systems for delivering substances into luminal walls |
US10076641B2 (en) | 2005-05-11 | 2018-09-18 | The Spectranetics Corporation | Methods and systems for delivering substances into luminal walls |
US9586031B2 (en) | 2005-05-11 | 2017-03-07 | Angioscore, Inc. | Methods and systems for delivering substances into luminal walls |
US11420030B2 (en) | 2005-05-11 | 2022-08-23 | Angioscore, Inc. | Methods and systems for delivering substances into luminal walls |
US11083823B2 (en) | 2005-09-28 | 2021-08-10 | Atrium Medical Corporation | Tissue-separating fatty acid adhesion barrier |
EP3150236A1 (de) * | 2006-02-09 | 2017-04-05 | B. Braun Melsungen AG | Faltenballonbeschichtungsverfahren |
EP3485920A1 (de) * | 2006-02-09 | 2019-05-22 | B. Braun Melsungen AG | Faltenballonbeschichtungsverfahren |
US10835719B2 (en) | 2006-11-20 | 2020-11-17 | Lutonix, Inc. | Drug releasing coatings for medical devices |
US9937159B2 (en) | 2006-11-20 | 2018-04-10 | Lutonix, Inc. | Treatment of asthma and chronic obstructive pulmonary disease with anti-proliferate and anti-inflammatory drugs |
US10485959B2 (en) | 2006-11-20 | 2019-11-26 | Lutonix, Inc. | Drug releasing coatings for balloon catheters |
US11534430B2 (en) | 2006-11-20 | 2022-12-27 | Lutonix, Inc. | Treatment of asthma and chronic obstructive pulmonary disease with anti-proliferate and anti-inflammatory drugs |
US9737640B2 (en) | 2006-11-20 | 2017-08-22 | Lutonix, Inc. | Drug releasing coatings for medical devices |
US9737691B2 (en) | 2006-11-20 | 2017-08-22 | Lutonix, Inc. | Drug releasing coatings for balloon catheters |
US10912931B2 (en) | 2006-11-20 | 2021-02-09 | Lutonix, Inc. | Drug releasing coatings for balloon catheters |
US9757351B2 (en) | 2006-11-20 | 2017-09-12 | Lutonix, Inc. | Medical device rapid drug releasing coatings comprising oils, fatty acids and/or lipids |
US11376404B2 (en) | 2006-11-20 | 2022-07-05 | Lutonix, Inc. | Drug releasing coatings for medical devices |
US10485958B2 (en) | 2006-11-20 | 2019-11-26 | Lutonix, Inc. | Drug releasing coatings for balloon catheters |
US9764065B2 (en) | 2006-11-20 | 2017-09-19 | Lutonix, Inc. | Drug releasing coatings for medical devices |
US10881644B2 (en) | 2006-11-20 | 2021-01-05 | Lutonix, Inc. | Treatment of asthma and chronic obstructive pulmonary disease with anti-proliferate and anti-inflammatory drugs |
US9757544B2 (en) | 2006-11-20 | 2017-09-12 | Lutonix, Inc. | Drug releasing coatings for medical devices |
US10994055B2 (en) | 2006-11-20 | 2021-05-04 | Lutonix, Inc. | Drug releasing coatings for medical devices |
US9700704B2 (en) | 2006-11-20 | 2017-07-11 | Lutonix, Inc. | Drug releasing coatings for balloon catheters |
US9694111B2 (en) | 2006-11-20 | 2017-07-04 | Lutonix, Inc. | Medical device rapid drug releasing coatings comprising a therapeutic agent and a contrast agent |
WO2008061642A3 (de) * | 2006-11-23 | 2009-05-22 | Alexander Ruebben | Verfahren zur erzeugung einer bioaktiven oberfläche auf dem ballon eines ballonkatheters |
WO2008061642A2 (de) * | 2006-11-23 | 2008-05-29 | Ruebben Alexander | Verfahren zur erzeugung einer bioaktiven oberfläche auf dem ballon eines ballonkatheters |
WO2008089730A2 (de) * | 2007-01-22 | 2008-07-31 | Eurocor Gmbh | Verfahren zur beladung von strukturierten oberflächen |
WO2008089730A3 (de) * | 2007-01-22 | 2009-09-24 | Eurocor Gmbh | Verfahren zur beladung von strukturierten oberflächen |
US8608689B2 (en) | 2007-08-03 | 2013-12-17 | Invatec Technology Center Gmbh | Pharmaceutical-coated medical products, the production thereof and the use thereof |
EP2682138A3 (de) * | 2007-08-03 | 2014-08-13 | Invatec Technology Center GMBH | Verbesserte arzneimittelbeschichtete Medizinprodukte, deren Herstellung und Verwendung |
KR101550470B1 (ko) | 2007-08-03 | 2015-09-04 | 인바텍 테크놀로지 센터 게엠베하 | 개선된 약제학적으로 코팅된 의약, 이의 제조 방법 및 이의 용도 |
WO2009018816A3 (de) * | 2007-08-03 | 2010-01-21 | Invatec Technology Center Gmbh | Verbesserte arzneimittelbeschichtete medizinprodukte, deren herstellung und verwendung |
US9220875B2 (en) | 2007-08-03 | 2015-12-29 | Invatec Technology Center Gmbh | Pharmaceutical-coated medical products, the production thereof and the use thereof |
US9974931B2 (en) | 2007-08-03 | 2018-05-22 | Invatec Technology Center Gmbh | Pharmaceutical-coated medical products, the production thereof and the use thereof |
RU2471508C2 (ru) * | 2007-08-03 | 2013-01-10 | Инватэк Текнолоджи Сентер Гмбх | Улучшенные покрытые слоем лекарственного вещества медицинские изделия, их изготовление и применение |
US10532189B2 (en) | 2007-08-29 | 2020-01-14 | Invatec Technology Center Gmbh | Controlled expansion balloon catheter |
US8613721B2 (en) | 2007-11-14 | 2013-12-24 | Medrad, Inc. | Delivery and administration of compositions using interventional catheters |
EP2789362A1 (de) | 2007-11-21 | 2014-10-15 | Invatec S.p.A. | Ballon zur Behandlung von Stenose |
WO2009066330A1 (en) | 2007-11-21 | 2009-05-28 | Invatec S.R.L. | Balloon for the treatment of stenosis and method for manufacturing the balloon |
EP2285443A2 (de) * | 2008-05-01 | 2011-02-23 | Bayer Schering Pharma AG | Wirkstoffhafttechniken und verfahren für katheterballon |
EP2285443B1 (de) * | 2008-05-01 | 2016-11-23 | Bayer Intellectual Property GmbH | Wirkstoffhafttechniken und verfahren für katheterballon |
US9770576B2 (en) | 2008-08-29 | 2017-09-26 | Lutonix, Inc. | Methods and apparatuses for coating balloon catheters |
US9180485B2 (en) | 2008-08-29 | 2015-11-10 | Lutonix, Inc. | Methods and apparatuses for coating balloon catheters |
US9132211B2 (en) | 2008-09-15 | 2015-09-15 | The Spectranetics Corporation | Local delivery of water-soluble or water-insoluble therapeutic agents to the surface of body lumens |
US10117970B2 (en) | 2008-09-15 | 2018-11-06 | The Spectranetics Corporation | Local delivery of water-soluble or water-insoluble therapeutic agents to the surface of body lumens |
US9603973B2 (en) | 2008-09-15 | 2017-03-28 | The Spectranetics Corporation | Local delivery of water-soluble or water-insoluble therapeutic agents to the surface of body lumens |
US10987452B2 (en) | 2008-09-15 | 2021-04-27 | The Spectranetics Corporation | Local delivery of water-soluble or water-insoluble therapeutic agents to the surface of body lumens |
US10314948B2 (en) | 2008-09-15 | 2019-06-11 | The Spectranetics Coporation | Local delivery of water-soluble or water-insoluble therapeutic agents to the surface of body lumens |
US8734825B2 (en) | 2008-09-15 | 2014-05-27 | Covidien Lp | Local delivery of water-soluble or water-insoluble therapeutic agents to the surface of body lumens |
US10046093B2 (en) | 2008-09-15 | 2018-08-14 | The Spectranetics Corporation | Local delivery of water-soluble or water-insoluble therapeutic agents to the surface of body lumens |
US9034362B2 (en) | 2008-09-15 | 2015-05-19 | The Spectranetics Corporation | Local delivery of water-soluble or water-insoluble therapeutic agents to the surface of body lumens |
US9730820B2 (en) | 2008-09-25 | 2017-08-15 | Abbott Cardiovascular Systems Inc. | Stent delivery system having a fibrous matrix covering with improved stent retention |
US11166929B2 (en) | 2009-03-10 | 2021-11-09 | Atrium Medical Corporation | Fatty-acid based particles |
EP2944332B1 (de) | 2009-07-10 | 2016-08-17 | Boston Scientific Scimed, Inc. | Verwendung von nanokristallen für einen wirkstofffreisetzungsballon |
US11278648B2 (en) | 2009-07-10 | 2022-03-22 | Boston Scientific Scimed, Inc. | Use of nanocrystals for drug delivery from a balloon |
US10369256B2 (en) | 2009-07-10 | 2019-08-06 | Boston Scientific Scimed, Inc. | Use of nanocrystals for drug delivery from a balloon |
US10080821B2 (en) | 2009-07-17 | 2018-09-25 | Boston Scientific Scimed, Inc. | Nucleation of drug delivery balloons to provide improved crystal size and density |
US10864304B2 (en) | 2009-08-11 | 2020-12-15 | Atrium Medical Corporation | Anti-infective antimicrobial-containing biomaterials |
WO2011044889A1 (de) * | 2009-10-16 | 2011-04-21 | Hemoteq Ag | Verwendung von zusammensetzungen zur beschichtung von katheterballons und beschichtete katheterballons |
US10195311B2 (en) | 2009-12-18 | 2019-02-05 | Interface Biologics, Inc. | Local delivery of drugs from self assembled coatings |
US10314947B2 (en) | 2010-04-19 | 2019-06-11 | Angioscore, Inc. | Coating formulations for scoring or cutting balloon catheters |
US10471184B2 (en) | 2010-04-19 | 2019-11-12 | Angioscore, Inc. | Coating formulations for scoring or cutting balloon catheters |
US9173977B2 (en) | 2010-04-19 | 2015-11-03 | Angioscore, Inc. | Coating formulations for scoring or cutting balloon catheters |
US11097035B2 (en) | 2010-07-16 | 2021-08-24 | Atrium Medical Corporation | Compositions and methods for altering the rate of hydrolysis of cured oil-based materials |
WO2012009412A1 (en) * | 2010-07-16 | 2012-01-19 | Abbott Cardiovascular Systems Inc. | Medical device having tissue engaging member and method for delivery of a therapeutic agent |
US9351756B2 (en) | 2010-09-21 | 2016-05-31 | Angioscore, Inc. | Method and system for treating valve stenosis |
US10736652B2 (en) | 2010-09-21 | 2020-08-11 | Angioscore, Inc. | Method and system for treating valve stenosis |
US9364254B2 (en) | 2010-09-21 | 2016-06-14 | Angioscore, Inc. | Method and system for treating valve stenosis |
WO2012072074A1 (de) | 2010-12-04 | 2012-06-07 | Ruebben Alexander | Beschichtung und beschichtungsverfahren für den ballon eines ballonkatheters sowie ballonkatheter mit beschichtetem ballon |
DE102011000340A1 (de) | 2010-12-04 | 2012-06-06 | Alexander Rübben | Beschichtung und Beschichtungsverfahren für den Ballon eines Ballonkatheters sowie Ballonkatheter mit beschichtetem Ballon |
WO2012084024A1 (en) | 2010-12-21 | 2012-06-28 | Invatec Technology Center Gmbh | Drug eluting balloon for the treatment of stenosis and method for manufacturing the balloon |
US9056152B2 (en) | 2011-08-25 | 2015-06-16 | Boston Scientific Scimed, Inc. | Medical device with crystalline drug coating |
US10888617B2 (en) | 2012-06-13 | 2021-01-12 | Atrium Medical Corporation | Cured oil-hydrogel biomaterial compositions for controlled drug delivery |
US9956385B2 (en) | 2012-06-28 | 2018-05-01 | The Spectranetics Corporation | Post-processing of a medical device to control morphology and mechanical properties |
US10485571B2 (en) | 2013-10-08 | 2019-11-26 | Angioscore, Inc. | Balloon catheter with non-deployable stent having improved stability |
US10117668B2 (en) | 2013-10-08 | 2018-11-06 | The Spectranetics Corporation | Balloon catheter with non-deployable stent having improved stability |
EP3088013A4 (de) * | 2013-12-26 | 2017-09-13 | Lifetech Scientific (Shenzhen) Co., Ltd. | Medikamentenbeschichteter ballonkatheter |
US10525171B2 (en) | 2014-01-24 | 2020-01-07 | The Spectranetics Corporation | Coatings for medical devices |
US11318232B2 (en) | 2018-05-22 | 2022-05-03 | Interface Biologics, Inc. | Compositions and methods for delivering drugs to a vessel wall |
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EP1539267B1 (de) | Medizinische vorrichtung zur arzneimittelabgabe | |
CH714779B1 (de) | Polysaccharidbeschichtung. | |
WO2021148445A1 (de) | Medizinprodukt zur arzneimittelabgabe mit verstärkter wirkung |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AK | Designated states |
Kind code of ref document: A2 Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DK DM DZ EC EE EG ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SY TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW |
|
AL | Designated countries for regional patents |
Kind code of ref document: A2 Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LU MC NL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG |
|
121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
REEP | Request for entry into the european phase |
Ref document number: 2003750586 Country of ref document: EP |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2003750586 Country of ref document: EP |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2004538961 Country of ref document: JP |
|
WWP | Wipo information: published in national office |
Ref document number: 2003750586 Country of ref document: EP |