WO1995026325B1 - Potentialisation de medicaments par deuteration_______________ - Google Patents

Potentialisation de medicaments par deuteration_______________

Info

Publication number
WO1995026325B1
WO1995026325B1 PCT/CA1995/000154 CA9500154W WO9526325B1 WO 1995026325 B1 WO1995026325 B1 WO 1995026325B1 CA 9500154 W CA9500154 W CA 9500154W WO 9526325 B1 WO9526325 B1 WO 9526325B1
Authority
WO
WIPO (PCT)
Prior art keywords
nifedipine
solution
dihydropyridine
deuterated
compound
Prior art date
Application number
PCT/CA1995/000154
Other languages
English (en)
Other versions
WO1995026325A2 (fr
WO1995026325A3 (fr
Filing date
Publication date
Application filed filed Critical
Priority to KR10-2004-7010591A priority Critical patent/KR20040068613A/ko
Priority to JP52488595A priority patent/JP3696884B2/ja
Priority to BR9507200A priority patent/BR9507200A/pt
Priority to EP95912109A priority patent/EP0751926B1/fr
Priority to KR1019960705390A priority patent/KR100477070B1/ko
Priority to AU19441/95A priority patent/AU707748B2/en
Priority to DE69535592T priority patent/DE69535592T2/de
Publication of WO1995026325A2 publication Critical patent/WO1995026325A2/fr
Publication of WO1995026325A3 publication Critical patent/WO1995026325A3/fr
Publication of WO1995026325B1 publication Critical patent/WO1995026325B1/fr
Priority to MXPA/A/1996/004309A priority patent/MXPA96004309A/xx

Links

Abstract

Un procédé permet de potentialiser des médicaments, des dihydropyridines, par exemple, et particulièrement la nifédipine, ainsi que d'en prolonger l'activité. Un ou plusieurs atomes d'hydrogène sont deutérés et la nifédipine ainsi deutérée présente des propriétés hypotensives étonnamment améliorées à des concentration bien plus faibles que la nifédipine elle-même. De plus un procédé qui permet de déterminer l'identité et la bioéquivalence d'un nouveau médicament recourt, pour en établir la structure moléculaire et isotopique, à la spectrométrie de masse à rapport isotopique et à la chromatographie en phase gazeuse, après quoi cette structure est comparée à la structure moléculaire et isotopique d'un médicament connu utilisé chez l'homme.
PCT/CA1995/000154 1994-03-25 1995-03-27 Potentialisation de medicaments par deuteration_______________ WO1995026325A2 (fr)

Priority Applications (8)

Application Number Priority Date Filing Date Title
KR10-2004-7010591A KR20040068613A (ko) 1994-03-25 1995-03-27 중수소화된 화합물 이를 포함하는 고혈압 치료용 조성물
JP52488595A JP3696884B2 (ja) 1994-03-25 1995-03-27 ジュウテリウム化による薬物の効能の増強
BR9507200A BR9507200A (pt) 1994-03-25 1995-03-27 Melhora da eficácia de drogas por deuteração
EP95912109A EP0751926B1 (fr) 1994-03-25 1995-03-27 Potentialisation de medicaments par deuteration---------------
KR1019960705390A KR100477070B1 (ko) 1994-03-25 1995-03-27 중수소화작용에의한의약품의효능강화법
AU19441/95A AU707748B2 (en) 1994-03-25 1995-03-27 Enhancement of the efficacy of drugs by deuteration
DE69535592T DE69535592T2 (de) 1994-03-25 1995-03-27 Verbesserung der effektivität von arzneimitteln duren deuterierung
MXPA/A/1996/004309A MXPA96004309A (en) 1994-03-25 1996-09-25 Increased drug effectiveness by deuterac

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US21789794A 1994-03-25 1994-03-25
US08/217,897 1994-03-25

Publications (3)

Publication Number Publication Date
WO1995026325A2 WO1995026325A2 (fr) 1995-10-05
WO1995026325A3 WO1995026325A3 (fr) 1995-12-14
WO1995026325B1 true WO1995026325B1 (fr) 1996-02-01

Family

ID=22812932

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CA1995/000154 WO1995026325A2 (fr) 1994-03-25 1995-03-27 Potentialisation de medicaments par deuteration_______________

Country Status (12)

Country Link
US (1) US5846514A (fr)
EP (1) EP0751926B1 (fr)
JP (1) JP3696884B2 (fr)
KR (2) KR20040068613A (fr)
CN (1) CN1087725C (fr)
AT (1) ATE372966T1 (fr)
AU (1) AU707748B2 (fr)
BR (1) BR9507200A (fr)
CA (1) CA2186371A1 (fr)
DE (1) DE69535592T2 (fr)
ES (1) ES2293638T3 (fr)
WO (1) WO1995026325A2 (fr)

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