PL2720989T3 - Deuterowane 1-piperazyno-3-fenyloindany do leczenia schizofrenii - Google Patents

Deuterowane 1-piperazyno-3-fenyloindany do leczenia schizofrenii

Info

Publication number
PL2720989T3
PL2720989T3 PL12748046T PL12748046T PL2720989T3 PL 2720989 T3 PL2720989 T3 PL 2720989T3 PL 12748046 T PL12748046 T PL 12748046T PL 12748046 T PL12748046 T PL 12748046T PL 2720989 T3 PL2720989 T3 PL 2720989T3
Authority
PL
Poland
Prior art keywords
piperazino
deuterated
schizophrenia
treatment
indanes
Prior art date
Application number
PL12748046T
Other languages
English (en)
Inventor
Morten Jorgensen
Peter Hongaard Andersen
Klaus Gjervig Jensen
Mette Graulund Hvenegaard
Lassina Badolo
Mikkel Fog Jacobsen
Original Assignee
H. Lundbeck A/S
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by H. Lundbeck A/S filed Critical H. Lundbeck A/S
Publication of PL2720989T3 publication Critical patent/PL2720989T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
    • C07D295/073—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/451—Non condensed piperidines, e.g. piperocaine having a carbocyclic group directly attached to the heterocyclic ring, e.g. glutethimide, meperidine, loperamide, phencyclidine, piminodine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/554—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one sulfur as ring hetero atoms, e.g. clothiapine, diltiazem
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/002—Heterocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05—Isotopically modified compounds, e.g. labelled
PL12748046T 2011-06-20 2012-06-19 Deuterowane 1-piperazyno-3-fenyloindany do leczenia schizofrenii PL2720989T3 (pl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161498651P 2011-06-20 2011-06-20
US201161537103P 2011-09-21 2011-09-21

Publications (1)

Publication Number Publication Date
PL2720989T3 true PL2720989T3 (pl) 2017-05-31

Family

ID=46682855

Family Applications (2)

Application Number Title Priority Date Filing Date
PL12748046T PL2720989T3 (pl) 2011-06-20 2012-06-19 Deuterowane 1-piperazyno-3-fenyloindany do leczenia schizofrenii
PL16179882T PL3135656T3 (pl) 2011-06-20 2012-06-19 Deuterowane 1-piperazyno-3-fenyloindany do leczenia schizofrenii

Family Applications After (1)

Application Number Title Priority Date Filing Date
PL16179882T PL3135656T3 (pl) 2011-06-20 2012-06-19 Deuterowane 1-piperazyno-3-fenyloindany do leczenia schizofrenii

Country Status (40)

Country Link
US (8) US8575174B2 (pl)
EP (4) EP2720989B1 (pl)
JP (1) JP5668177B2 (pl)
KR (2) KR101879474B1 (pl)
CN (1) CN103649019B (pl)
AP (1) AP3310A (pl)
AR (1) AR086987A1 (pl)
AU (1) AU2012273657B2 (pl)
BR (1) BR112013031702B1 (pl)
CA (1) CA2837820C (pl)
CL (1) CL2013003646A1 (pl)
CO (1) CO6821965A2 (pl)
CR (1) CR20130654A (pl)
CY (2) CY1118158T1 (pl)
DK (2) DK3135656T3 (pl)
DO (1) DOP2013000305A (pl)
EA (1) EA024651B1 (pl)
EC (1) ECSP14013155A (pl)
ES (3) ES2939477T3 (pl)
GE (1) GEP201706655B (pl)
GT (1) GT201300304A (pl)
HK (1) HK1197228A1 (pl)
HR (2) HRP20161348T1 (pl)
HU (2) HUE030883T2 (pl)
IL (1) IL229640B (pl)
JO (1) JO3128B1 (pl)
LT (2) LT3135656T (pl)
MA (1) MA35268B1 (pl)
MD (1) MD4538C1 (pl)
ME (2) ME03375B (pl)
MX (1) MX339552B (pl)
MY (1) MY196998A (pl)
PE (2) PE20141113A1 (pl)
PL (2) PL2720989T3 (pl)
PT (2) PT2720989T (pl)
RS (2) RS58546B1 (pl)
SI (2) SI3135656T1 (pl)
SM (1) SMT201600383B (pl)
TW (3) TWI659741B (pl)
WO (1) WO2012176066A1 (pl)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK3135656T3 (en) * 2011-06-20 2019-04-23 H Lundbeck As DEUTERATED 1-PIPERAZINO-3-PHENYL INDANES FOR TREATMENT OF schizophrenia
AR094054A1 (es) * 2012-12-19 2015-07-08 H Lundbeck As 6-cloro-3-(fenil-d₅)-inden-1-ona y uso de la misma
PT3679018T (pt) 2017-09-07 2022-04-05 Otsuka Pharma Co Ltd Processo industrial de monoalquilação de um nitrogénio de piperidina em derivados de piperidina com alquilo deuterado
JP7442538B2 (ja) 2018-10-29 2024-03-04 ハー・ルンドベック・アクチエゼルスカベット 非晶性の式（ｉ）の化合物及び非晶性の式（ｉ）の化合物塩
CN113056457A (zh) 2018-12-03 2021-06-29 H.隆德贝克有限公司 4-((1R,3S)-6-氯-3-苯基-2,3-二氢-1H-茚-1-基)-1,2,2-三甲基哌嗪和4-((1R,3S)-6-氯-3-(苯基-d5)-2,3-二氢-1H-茚-1-基)-2,2-二甲基-1-(甲基-d3)哌嗪的前药
SG11202106692UA (en) * 2018-12-21 2021-07-29 Concert Pharmaceuticals Inc Deuterated forms and derivatives of volinanserin
KR20210139317A (ko) 2019-03-13 2021-11-22 오츠카 세이야쿠 가부시키가이샤 2급 아민을 함유하는 화합물의 아민 부분에 중수소 저급 알킬을 도입하는 방법

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ196284A (en) 1980-02-29 1983-12-16 Kefalas As 1-piperazino-3-phenylindane derivatives:pharmaceutical compositions
GB8427125D0 (en) 1984-10-26 1984-12-05 Lundbeck & Co As H Organic compounds
DK286990D0 (da) 1990-12-04 1990-12-04 Lundbeck & Co As H Indanderivater
DK55192D0 (da) * 1992-04-28 1992-04-28 Lundbeck & Co As H 1-piperazino-1,2-dihydroindenderivater
US6221335B1 (en) 1994-03-25 2001-04-24 Isotechnika, Inc. Method of using deuterated calcium channel blockers
KR20040068613A (ko) * 1994-03-25 2004-07-31 이소테크니카 인코포레이티드 중수소화된 화합물 이를 포함하는 고혈압 치료용 조성물
UA81749C2 (uk) 2001-10-04 2008-02-11 Х. Луннбек А/С Фенілпіперазинові похідні як інгібітори зворотного захоплення серотоніну
JP5043429B2 (ja) 2003-08-18 2012-10-10 ハー・ルンドベック・アクチエゼルスカベット トランス−４−（（１ｒ，３ｓ）−６−クロロ−３−フェニルインダン−１−イル）−１，２，２−トリメチルピペラジンのコハク酸塩およびマロン酸塩、および薬剤としての使用方法
SG145723A1 (en) * 2003-08-18 2008-09-29 Lundbeck & Co As H Trans-1(6-chloro-3-phenylindan-1-yl)-3,3-dimethylpiperazine
JP2008530039A (ja) * 2005-02-16 2008-08-07 ハー・ルンドベック・アクチエゼルスカベット トランス−１−（（１ｒ，３ｓ）−６−クロロ−３−フェニルインダン−１−イル）−３，３−ジメチルピペラジンの酒石酸塩およびリンゴ酸塩
TWI376373B (en) 2005-02-16 2012-11-11 Lundbeck & Co As H Crystalline base of a pharmaceutical compound
TWI453198B (zh) 2005-02-16 2014-09-21 Lundbeck & Co As H 製造反式-1-((1r,3s)-6-氯基-3-苯基茚滿-1-基) -3 , 3 -二甲基六氫吡與其鹽類之方法及製造4-((1r , 3s）-6 -氯基-3-苯基茚滿-1-基 )-1,2,2-三甲基六氫吡與其鹽類之方法
US7863274B2 (en) 2005-07-29 2011-01-04 Concert Pharmaceuticals Inc. Deuterium enriched analogues of tadalafil as PDE5 inhibitors
JP5301991B2 (ja) 2005-07-29 2013-09-25 コンサート ファーマシューティカルズ インコーポレイテッド 新規なベンゾ［ｄ］［１，３］−ジオキソール誘導体
KR101068180B1 (ko) 2005-12-01 2011-09-28 오스펙스 파마슈티칼스, 인코포레이티드 세로토닌성 및/또는 노르에피네프린성 활성을 갖는 치환된펜에틸아민
JP4986462B2 (ja) 2006-01-27 2012-07-25 シャープ株式会社 太陽電池ストリングおよびその製造方法、ならびに、その太陽電池ストリングを用いる太陽電池モジュール
TW200819426A (en) 2006-08-31 2008-05-01 Lundbeck & Co As H Novel indane compounds
US8198305B2 (en) 2007-04-13 2012-06-12 Concert Pharmaceuticals Inc. 1,2-benzisoxazol-3-yl compounds
EP2148867B1 (en) 2007-04-19 2014-09-10 Concert Pharmaceuticals Inc. Deuterated morpholinyl compounds
ES2394952T3 (es) 2007-06-12 2013-02-07 Concert Pharmaceuticals Inc. Derivados de axapéptido como inhibidores de la proteasa VIH
US20090062303A1 (en) 2007-08-29 2009-03-05 Protia, Llc Deuterium-enriched ziprasidone
MX2010012037A (es) 2008-05-07 2010-11-30 Lundbeck & Co As H Composiciones y uso utiles para tratar trastornos cognitivos.
US20110178094A1 (en) 2008-10-03 2011-07-21 H. Lundbeck A/S Oral Formulation
US20120071554A1 (en) 2008-10-28 2012-03-22 Liu Julie F Deuterated 2-propylpentanoic acid compounds
US8263601B2 (en) 2009-02-27 2012-09-11 Concert Pharmaceuticals, Inc. Deuterium substituted xanthine derivatives
US8658236B2 (en) * 2009-08-21 2014-02-25 Deuteria Beverages, Llc Alcoholic compositions having a lowered risk of acetaldehydemia
CN102020522A (zh) * 2009-09-21 2011-04-20 陈松源 氘代药物的制备方法和应用
US8278460B2 (en) 2009-10-15 2012-10-02 Concert Pharmaceuticals, Inc. Substituted benzimidazoles
WO2011059080A1 (ja) * 2009-11-16 2011-05-19 第一三共株式会社 同位体置換されたジアミン誘導体
DK3135656T3 (en) 2011-06-20 2019-04-23 H Lundbeck As DEUTERATED 1-PIPERAZINO-3-PHENYL INDANES FOR TREATMENT OF schizophrenia

Also Published As

Publication number Publication date
PE20150928A1 (es) 2015-06-26
US20220119362A1 (en) 2022-04-21
SI3135656T1 (sl) 2019-05-31
US20200131143A1 (en) 2020-04-30
HUE030883T2 (en) 2017-06-28
CO6821965A2 (es) 2013-12-31
EP2720989B1 (en) 2016-08-10
JP2014520140A (ja) 2014-08-21
TWI614234B (zh) 2018-02-11
DK3135656T3 (en) 2019-04-23
ES2719145T3 (es) 2019-07-08
KR101939546B1 (ko) 2019-01-16
US20120322811A1 (en) 2012-12-20
AP3310A (en) 2015-06-30
LT3135656T (lt) 2019-04-25
CA2837820A1 (en) 2012-12-27
ES2939477T3 (es) 2023-04-24
MX2013014849A (es) 2014-03-31
US9012453B2 (en) 2015-04-21
MD20140004A2 (en) 2014-05-31
EP3135656A1 (en) 2017-03-01
WO2012176066A1 (en) 2012-12-27
JO3128B1 (ar) 2017-09-20
US9216961B2 (en) 2015-12-22
HRP20190593T1 (hr) 2019-05-17
CA2837820C (en) 2019-02-19
TWI627956B (zh) 2018-07-01
DK2720989T3 (en) 2016-11-28
US10501427B2 (en) 2019-12-10
EP3508468B1 (en) 2023-01-18
EA024651B1 (ru) 2016-10-31
MY196998A (en) 2023-05-17
KR20180075717A (ko) 2018-07-04
BR112013031702B1 (pt) 2021-11-03
JP5668177B2 (ja) 2015-02-12
US20130281436A1 (en) 2013-10-24
BR112013031702A2 (pt) 2016-12-13
AP2013007338A0 (en) 2013-12-31
CN103649019A (zh) 2014-03-19
ECSP14013155A (es) 2014-02-28
ME03375B (me) 2020-01-20
AU2012273657A1 (en) 2013-12-12
HRP20161348T1 (hr) 2016-12-02
US9617231B2 (en) 2017-04-11
GT201300304A (es) 2015-01-16
US10118907B2 (en) 2018-11-06
CY1118158T1 (el) 2017-06-28
SI2720989T1 (sl) 2016-11-30
PT3135656T (pt) 2019-05-03
CL2013003646A1 (es) 2014-07-04
EP4215512A1 (en) 2023-07-26
US11059798B2 (en) 2021-07-13
GEP201706655B (en) 2017-04-25
AU2012273657B2 (en) 2016-07-21
EP3508468A1 (en) 2019-07-10
PL3135656T3 (pl) 2019-07-31
IL229640A0 (en) 2014-01-30
ES2601213T3 (es) 2017-02-14
CN103649019B (zh) 2015-09-16
HK1197228A1 (zh) 2015-01-09
TW201902481A (zh) 2019-01-16
US20170158650A1 (en) 2017-06-08
CR20130654A (es) 2014-03-24
PT2720989T (pt) 2016-11-07
HUE044043T2 (hu) 2019-09-30
TW201722895A (zh) 2017-07-01
RS58546B1 (sr) 2019-05-31
US20160068497A1 (en) 2016-03-10
LT2720989T (lt) 2016-11-25
NZ618222A (en) 2015-03-27
AR086987A1 (es) 2014-02-05
KR20140041567A (ko) 2014-04-04
EA201490045A1 (ru) 2014-07-30
MX339552B (es) 2016-05-31
IL229640B (en) 2018-02-28
US20190031631A1 (en) 2019-01-31
MD4538C1 (ro) 2018-07-31
PE20141113A1 (es) 2014-09-25
TWI659741B (zh) 2019-05-21
CY1121514T1 (el) 2020-05-29
TW201311248A (zh) 2013-03-16
MD4538B1 (ro) 2017-12-31
EP3135656B1 (en) 2019-02-27
US8575174B2 (en) 2013-11-05
DOP2013000305A (es) 2014-02-28
US20150307458A1 (en) 2015-10-29
RS55304B1 (sr) 2017-03-31
MA35268B1 (fr) 2014-07-03
SMT201600383B (it) 2017-01-10
EP2720989A1 (en) 2014-04-23
ME02513B (me) 2017-02-20
KR101879474B1 (ko) 2018-07-17

Similar Documents

Publication Publication Date Title
HK1244183A1 (zh) Ivacaftor的氘化衍生物
EP2723384A4 (en) TREATMENT OF PROTEINOPATHIES
HRP20190593T1 (hr) Deuterirani 1-piperazino-3-fenil indani za liječenje shizofrenije
HUE047354T2 (hu) Ivacaftor deuterizált származékai
EP2773754A4 (en) Methods of Treatment
EP2717855A4 (en) PROCESSING METHODS
GB201110095D0 (en) Method of treatment
GB201106960D0 (en) Treatment of waste
HK1199261A1 (en) Methods for treatment of diseases
EP2709665A4 (en) TREATMENT OF PSORIASIS
ZA201309613B (en) Deuterated 1-piperazino-3-phenyl indanes for treatment of schizophrenia
EP2791324A4 (en) PROCESSING METHOD
HK1199818A1 (en) Treatment of seborrhoea
GB201118065D0 (en) Treatment of movement disorders
GB201110602D0 (en) Methods of treatment
GB201109737D0 (en) Methods of treatment
EP2696872A4 (en) TREATMENT OF GLAUCOMA
GB201121044D0 (en) Treatment of solutions
GB201118269D0 (en) Treatment of cardiovascular disease
GB201111530D0 (en) Method of treatment
GB201109509D0 (en) Method of treatment
GB201109266D0 (en) Method of treatment
GB201107988D0 (en) Treatment of cardiovascular disease
GB201103044D0 (en) Method of treatment