US20070003616A1 - Process for the production of an abuse-proofed dosage form - Google Patents
Process for the production of an abuse-proofed dosage form Download PDFInfo
- Publication number
- US20070003616A1 US20070003616A1 US11/471,438 US47143806A US2007003616A1 US 20070003616 A1 US20070003616 A1 US 20070003616A1 US 47143806 A US47143806 A US 47143806A US 2007003616 A1 US2007003616 A1 US 2007003616A1
- Authority
- US
- United States
- Prior art keywords
- dosage form
- abuse
- optionally
- force
- active ingredient
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
- A61K31/515—Barbituric acids; Derivatives thereof, e.g. sodium pentobarbital
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B30—PRESSES
- B30B—PRESSES IN GENERAL
- B30B11/00—Presses specially adapted for forming shaped articles from material in particulate or plastic state, e.g. briquetting presses, tabletting presses
- B30B11/16—Presses specially adapted for forming shaped articles from material in particulate or plastic state, e.g. briquetting presses, tabletting presses using pocketed rollers, e.g. two co-operating pocketed rollers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B30—PRESSES
- B30B—PRESSES IN GENERAL
- B30B11/00—Presses specially adapted for forming shaped articles from material in particulate or plastic state, e.g. briquetting presses, tabletting presses
- B30B11/34—Presses specially adapted for forming shaped articles from material in particulate or plastic state, e.g. briquetting presses, tabletting presses for coating articles, e.g. tablets
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Mechanical Engineering (AREA)
- Neurosurgery (AREA)
- Addiction (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Emergency Medicine (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US12/140,718 US20090005408A1 (en) | 2003-12-24 | 2008-06-17 | Process for the production of an abuse-proofed dosage form |
US13/962,098 US20130320592A1 (en) | 2003-12-24 | 2013-08-08 | Process for the production of an abuse-proofed dosage form |
US14/580,578 US20150164811A1 (en) | 2003-12-24 | 2014-12-23 | Process for the production of an abuse-proofed dosage form |
US15/255,441 US20170049706A1 (en) | 2003-12-24 | 2016-09-02 | Process for the production of an abuse-proofed dosage form |
US15/257,079 US11224576B2 (en) | 2003-12-24 | 2016-09-06 | Process for the production of an abuse-proofed dosage form |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10361596.2 | 2003-12-24 | ||
DE10361596A DE10361596A1 (de) | 2003-12-24 | 2003-12-24 | Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform |
PCT/EP2004/014679 WO2005063214A1 (de) | 2003-12-24 | 2004-12-23 | Verfahren zur herstellung einer gegen missbrauch gesicherten darreichungsform |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2004/014679 Continuation WO2005063214A1 (de) | 2003-12-24 | 2004-12-23 | Verfahren zur herstellung einer gegen missbrauch gesicherten darreichungsform |
Related Child Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US12/140,718 Division US20090005408A1 (en) | 2003-12-24 | 2008-06-17 | Process for the production of an abuse-proofed dosage form |
US14/580,578 Continuation US20150164811A1 (en) | 2003-12-24 | 2014-12-23 | Process for the production of an abuse-proofed dosage form |
Publications (1)
Publication Number | Publication Date |
---|---|
US20070003616A1 true US20070003616A1 (en) | 2007-01-04 |
Family
ID=34716231
Family Applications (6)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US11/471,438 Abandoned US20070003616A1 (en) | 2003-12-24 | 2006-06-20 | Process for the production of an abuse-proofed dosage form |
US12/140,718 Abandoned US20090005408A1 (en) | 2003-12-24 | 2008-06-17 | Process for the production of an abuse-proofed dosage form |
US13/962,098 Abandoned US20130320592A1 (en) | 2003-12-24 | 2013-08-08 | Process for the production of an abuse-proofed dosage form |
US14/580,578 Abandoned US20150164811A1 (en) | 2003-12-24 | 2014-12-23 | Process for the production of an abuse-proofed dosage form |
US15/255,441 Abandoned US20170049706A1 (en) | 2003-12-24 | 2016-09-02 | Process for the production of an abuse-proofed dosage form |
US15/257,079 Active US11224576B2 (en) | 2003-12-24 | 2016-09-06 | Process for the production of an abuse-proofed dosage form |
Family Applications After (5)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US12/140,718 Abandoned US20090005408A1 (en) | 2003-12-24 | 2008-06-17 | Process for the production of an abuse-proofed dosage form |
US13/962,098 Abandoned US20130320592A1 (en) | 2003-12-24 | 2013-08-08 | Process for the production of an abuse-proofed dosage form |
US14/580,578 Abandoned US20150164811A1 (en) | 2003-12-24 | 2014-12-23 | Process for the production of an abuse-proofed dosage form |
US15/255,441 Abandoned US20170049706A1 (en) | 2003-12-24 | 2016-09-02 | Process for the production of an abuse-proofed dosage form |
US15/257,079 Active US11224576B2 (en) | 2003-12-24 | 2016-09-06 | Process for the production of an abuse-proofed dosage form |
Country Status (19)
Country | Link |
---|---|
US (6) | US20070003616A1 (de) |
EP (1) | EP1699440B1 (de) |
JP (1) | JP4895821B2 (de) |
CN (1) | CN1917862B (de) |
AR (1) | AR046994A1 (de) |
AT (1) | ATE447942T1 (de) |
AU (1) | AU2004308653B2 (de) |
CA (1) | CA2551231A1 (de) |
CY (1) | CY1110609T1 (de) |
DE (2) | DE10361596A1 (de) |
DK (1) | DK1699440T3 (de) |
ES (1) | ES2336571T3 (de) |
HK (1) | HK1099511A1 (de) |
IL (1) | IL176296A0 (de) |
PE (1) | PE20050814A1 (de) |
PL (1) | PL1699440T3 (de) |
PT (1) | PT1699440E (de) |
SI (1) | SI1699440T1 (de) |
WO (1) | WO2005063214A1 (de) |
Cited By (60)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20050031546A1 (en) * | 2003-08-06 | 2005-02-10 | Johannes Bartholomaus | Abuse-proffed dosage form |
US20050236741A1 (en) * | 2004-04-22 | 2005-10-27 | Elisabeth Arkenau | Process for the production of an abuse-proofed solid dosage form |
US20060002859A1 (en) * | 2004-07-01 | 2006-01-05 | Elisabeth Arkenau | Process for production of an abuse-proofed solid dosage form |
US20060039864A1 (en) * | 2004-07-01 | 2006-02-23 | Johannes Bartholomaus | Abuse-proofed oral dosage form |
US20060188447A1 (en) * | 2005-02-04 | 2006-08-24 | Elisabeth Arkenau-Maric | Process for the production of an abuse-proofed dosage form |
US20060193914A1 (en) * | 2005-02-04 | 2006-08-31 | Judy Ashworth | Crush resistant delayed-release dosage forms |
US20070048228A1 (en) * | 2003-08-06 | 2007-03-01 | Elisabeth Arkenau-Maric | Abuse-proofed dosage form |
US20070183979A1 (en) * | 2003-08-06 | 2007-08-09 | Elisabeth Arkenau-Maric | Abuse-proofed dosage form |
US20070183980A1 (en) * | 2003-08-06 | 2007-08-09 | Elisabeth Arkenau-Maric | Dosage form that is safeguarded from abuse |
US20080020032A1 (en) * | 2006-07-21 | 2008-01-24 | Michael Crowley | Hydrophobic abuse deterrent delivery system for hydromorphone |
US20080248113A1 (en) * | 2004-07-01 | 2008-10-09 | Grunenthal Gmbh | Abuse-proofed oral dosage form |
US20090005408A1 (en) * | 2003-12-24 | 2009-01-01 | Grunenthal Gmbh | Process for the production of an abuse-proofed dosage form |
US20090004267A1 (en) * | 2007-03-07 | 2009-01-01 | Gruenenthal Gmbh | Dosage Form with Impeded Abuse |
US20090081290A1 (en) * | 2006-08-25 | 2009-03-26 | Purdue Pharma L.P. | Tamper resistant dosage forms |
US20090202634A1 (en) * | 2008-01-25 | 2009-08-13 | Grunenthal Gmbh | Pharmaceutical dosage form |
US20100015223A1 (en) * | 2006-03-01 | 2010-01-21 | Ethypharm Sa | Crush-Resistant Tablets Intended to Prevent Accidental Misuse and Unlawful Diversion |
US20110020451A1 (en) * | 2009-07-22 | 2011-01-27 | Grunenthal Gmbh | Tamper-resistant dosage form for oxidation-sensitive opioids |
US20110082214A1 (en) * | 2008-05-09 | 2011-04-07 | Gruenthal Gmbh | Process for the preparation of a solid dosage form, in particular a tablet, for pharmaceutical use and process for the preparation of a precursor for a solid dosage form, in particular a tablet |
US20110187017A1 (en) * | 2010-02-03 | 2011-08-04 | Grunenthal Gmbh | Preparation of a powdery pharmaceutical composition by means of an extruder |
US20110237615A1 (en) * | 2008-12-12 | 2011-09-29 | Paladin Labs Inc. | Narcotic Drug Formulations with Decreased Abuse Potential |
WO2012085657A2 (en) | 2010-12-23 | 2012-06-28 | Purdue Pharma L.P. | Tamper resistant solid oral dosage forms |
US8337888B2 (en) | 2001-08-06 | 2012-12-25 | Purdue Pharma L.P. | Pharmaceutical formulation containing gelling agent |
US8808740B2 (en) | 2010-12-22 | 2014-08-19 | Purdue Pharma L.P. | Encased tamper resistant controlled release dosage forms |
US8808745B2 (en) | 2001-09-21 | 2014-08-19 | Egalet Ltd. | Morphine polymer release system |
US8877241B2 (en) | 2003-03-26 | 2014-11-04 | Egalet Ltd. | Morphine controlled release system |
US9005660B2 (en) | 2009-02-06 | 2015-04-14 | Egalet Ltd. | Immediate release composition resistant to abuse by intake of alcohol |
US9023394B2 (en) | 2009-06-24 | 2015-05-05 | Egalet Ltd. | Formulations and methods for the controlled release of active drug substances |
US9044402B2 (en) | 2012-07-06 | 2015-06-02 | Egalet Ltd. | Abuse-deterrent pharmaceutical compositions for controlled release |
US9149533B2 (en) | 2013-02-05 | 2015-10-06 | Purdue Pharma L.P. | Tamper resistant pharmaceutical formulations |
US9216176B2 (en) | 2006-09-15 | 2015-12-22 | Cima Labs Inc. | Abuse resistant drug formulation |
US9616030B2 (en) | 2013-03-15 | 2017-04-11 | Purdue Pharma L.P. | Tamper resistant pharmaceutical formulations |
US9636303B2 (en) | 2010-09-02 | 2017-05-02 | Gruenenthal Gmbh | Tamper resistant dosage form comprising an anionic polymer |
US9642809B2 (en) | 2007-06-04 | 2017-05-09 | Egalet Ltd. | Controlled release pharmaceutical compositions for prolonged effect |
US9655853B2 (en) | 2012-02-28 | 2017-05-23 | Grünenthal GmbH | Tamper-resistant dosage form comprising pharmacologically active compound and anionic polymer |
US9675610B2 (en) | 2002-06-17 | 2017-06-13 | Grünenthal GmbH | Abuse-proofed dosage form |
US9694080B2 (en) | 2001-09-21 | 2017-07-04 | Egalet Ltd. | Polymer release system |
US9730885B2 (en) | 2012-07-12 | 2017-08-15 | Mallinckrodt Llc | Extended release, abuse deterrent pharmaceutical compositions |
US9737490B2 (en) | 2013-05-29 | 2017-08-22 | Grünenthal GmbH | Tamper resistant dosage form with bimodal release profile |
US9757338B2 (en) | 2010-03-01 | 2017-09-12 | Dexcel Pharma Technologies Ltd. | Sustained-release donepezil formulation |
US9855263B2 (en) | 2015-04-24 | 2018-01-02 | Grünenthal GmbH | Tamper-resistant dosage form with immediate release and resistance against solvent extraction |
US9861629B1 (en) | 2015-10-07 | 2018-01-09 | Banner Life Sciences Llc | Opioid abuse deterrent dosage forms |
US9872835B2 (en) | 2014-05-26 | 2018-01-23 | Grünenthal GmbH | Multiparticles safeguarded against ethanolic dose-dumping |
US9913814B2 (en) | 2014-05-12 | 2018-03-13 | Grünenthal GmbH | Tamper resistant immediate release capsule formulation comprising tapentadol |
US10064945B2 (en) | 2012-05-11 | 2018-09-04 | Gruenenthal Gmbh | Thermoformed, tamper-resistant pharmaceutical dosage form containing zinc |
US10080721B2 (en) | 2009-07-22 | 2018-09-25 | Gruenenthal Gmbh | Hot-melt extruded pharmaceutical dosage form |
US10154966B2 (en) | 2013-05-29 | 2018-12-18 | Grünenthal GmbH | Tamper-resistant dosage form containing one or more particles |
US10201502B2 (en) | 2011-07-29 | 2019-02-12 | Gruenenthal Gmbh | Tamper-resistant tablet providing immediate drug release |
US10300141B2 (en) | 2010-09-02 | 2019-05-28 | Grünenthal GmbH | Tamper resistant dosage form comprising inorganic salt |
US10335405B1 (en) | 2016-05-04 | 2019-07-02 | Patheon Softgels, Inc. | Non-burst releasing pharmaceutical composition |
US10335375B2 (en) | 2017-05-30 | 2019-07-02 | Patheon Softgels, Inc. | Anti-overingestion abuse deterrent compositions |
US10335373B2 (en) | 2012-04-18 | 2019-07-02 | Grunenthal Gmbh | Tamper resistant and dose-dumping resistant pharmaceutical dosage form |
US10449547B2 (en) | 2013-11-26 | 2019-10-22 | Grünenthal GmbH | Preparation of a powdery pharmaceutical composition by means of cryo-milling |
US10525053B2 (en) | 2002-07-05 | 2020-01-07 | Collegium Pharmaceutical, Inc. | Abuse-deterrent pharmaceutical compositions of opioids and other drugs |
US10624862B2 (en) | 2013-07-12 | 2020-04-21 | Grünenthal GmbH | Tamper-resistant dosage form containing ethylene-vinyl acetate polymer |
US10632201B2 (en) | 2017-10-19 | 2020-04-28 | Capsugel Belgium Nv | Immediate release abuse deterrent formulations |
US10646485B2 (en) | 2016-06-23 | 2020-05-12 | Collegium Pharmaceutical, Inc. | Process of making stable abuse-deterrent oral formulations |
US10668060B2 (en) | 2009-12-10 | 2020-06-02 | Collegium Pharmaceutical, Inc. | Tamper-resistant pharmaceutical compositions of opioids and other drugs |
US10695297B2 (en) | 2011-07-29 | 2020-06-30 | Grünenthal GmbH | Tamper-resistant tablet providing immediate drug release |
US10842750B2 (en) | 2015-09-10 | 2020-11-24 | Grünenthal GmbH | Protecting oral overdose with abuse deterrent immediate release formulations |
US11964056B1 (en) | 2023-09-27 | 2024-04-23 | Purdue Pharma L.P | Tamper resistant dosage forms |
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---|---|---|---|---|
US7201920B2 (en) | 2003-11-26 | 2007-04-10 | Acura Pharmaceuticals, Inc. | Methods and compositions for deterring abuse of opioid containing dosage forms |
JP5259183B2 (ja) * | 2004-07-01 | 2013-08-07 | グリューネンタール・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | 乱用に対して保護された経口剤形 |
FR2889810A1 (fr) * | 2005-05-24 | 2007-02-23 | Flamel Technologies Sa | Forme medicamenteuse orale, microparticulaire, anti-mesurage |
DE102007025858A1 (de) | 2007-06-01 | 2008-12-04 | Grünenthal GmbH | Verfahren zur Herstellung einer Arzneimitteldarreichungsform |
US20090006161A1 (en) * | 2007-06-27 | 2009-01-01 | Yen-Fu Chen | Systems and methods for managing events of event scheduling applications |
DE102007039043A1 (de) | 2007-08-17 | 2009-02-19 | Grünenthal GmbH | Sternverteiler |
US8200520B2 (en) * | 2007-10-03 | 2012-06-12 | International Business Machines Corporation | Methods, systems, and apparatuses for automated confirmations of meetings |
ES2569925T3 (es) | 2009-09-30 | 2016-05-13 | Acura Pharmaceuticals, Inc. | Métodos y composiciones de disuasión del abuso |
WO2012028317A1 (en) | 2010-09-02 | 2012-03-08 | Grünenthal GmbH | Tamper resistant dosage form comprising an anionic polymer |
AU2012320496C1 (en) | 2011-10-06 | 2017-09-28 | Grünenthal GmbH | Tamper-resistant oral pharmaceutical dosage form comprising opioid agonist and opioid antagonist |
KR20140096062A (ko) | 2011-11-17 | 2014-08-04 | 그뤼넨탈 게엠베하 | 약리학적 활성 성분, 오피오이드 길항제 및/또는 혐오제, 폴리알킬렌 옥사이드 및 음이온성 중합체를 포함하는 탬퍼-저항성 경구 약제학적 투여형 |
US20130225625A1 (en) | 2012-02-28 | 2013-08-29 | Grunenthal Gmbh | Tamper-resistant pharmaceutical dosage form comprising nonionic surfactant |
NO2846835T3 (de) | 2012-05-11 | 2018-02-03 | ||
RU2673818C2 (ru) | 2012-11-30 | 2018-11-30 | Экьюра Фармасьютикалз, Инк. | Саморегулируемое высвобождение фармацевтического ингредиента |
EP3082781A1 (de) | 2013-12-16 | 2016-10-26 | Grünenthal GmbH | Koextrusionsgefertigte manipulationssichere darreichungsform mit bimodalem freisetzungsprofil |
US9642811B2 (en) | 2014-03-26 | 2017-05-09 | Sun Pharma Advanced Research Company Ltd. | Abuse deterrent immediate release biphasic matrix solid dosage form |
EP3253376A1 (de) | 2015-02-03 | 2017-12-13 | Grünenthal GmbH | Manipulationssichere darreichungsform mit polyethylenglykolpfropfcopolymer |
EP3285748A1 (de) | 2015-04-24 | 2018-02-28 | Grünenthal GmbH | Manipulationssichere festdosiskombination mit schneller freisetzung von zwei wirkstoffen aus verschiedenen partikeln |
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2003
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2004
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- 2004-12-23 SI SI200431334T patent/SI1699440T1/sl unknown
- 2004-12-23 AU AU2004308653A patent/AU2004308653B2/en not_active Ceased
- 2004-12-23 WO PCT/EP2004/014679 patent/WO2005063214A1/de active Application Filing
- 2004-12-23 JP JP2006546080A patent/JP4895821B2/ja not_active Expired - Fee Related
- 2004-12-23 AT AT04804271T patent/ATE447942T1/de active
- 2004-12-23 DK DK04804271.7T patent/DK1699440T3/da active
- 2004-12-23 ES ES04804271T patent/ES2336571T3/es active Active
- 2004-12-23 PT PT04804271T patent/PT1699440E/pt unknown
- 2004-12-23 PL PL04804271T patent/PL1699440T3/pl unknown
- 2004-12-23 EP EP04804271A patent/EP1699440B1/de active Active
- 2004-12-23 CN CN2004800418549A patent/CN1917862B/zh not_active Expired - Fee Related
- 2004-12-23 DE DE502004010368T patent/DE502004010368D1/de active Active
- 2004-12-23 CA CA002551231A patent/CA2551231A1/en not_active Abandoned
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2005
- 2005-01-03 PE PE2005000026A patent/PE20050814A1/es not_active Application Discontinuation
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2006
- 2006-06-14 IL IL176296A patent/IL176296A0/en active IP Right Grant
- 2006-06-20 US US11/471,438 patent/US20070003616A1/en not_active Abandoned
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2007
- 2007-03-13 HK HK07102732.2A patent/HK1099511A1/xx not_active IP Right Cessation
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2008
- 2008-06-17 US US12/140,718 patent/US20090005408A1/en not_active Abandoned
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2010
- 2010-02-11 CY CY20101100142T patent/CY1110609T1/el unknown
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2013
- 2013-08-08 US US13/962,098 patent/US20130320592A1/en not_active Abandoned
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2014
- 2014-12-23 US US14/580,578 patent/US20150164811A1/en not_active Abandoned
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2016
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Also Published As
Publication number | Publication date |
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US20090005408A1 (en) | 2009-01-01 |
PT1699440E (pt) | 2010-02-17 |
US20160367487A1 (en) | 2016-12-22 |
EP1699440B1 (de) | 2009-11-11 |
DE502004010368D1 (de) | 2009-12-24 |
WO2005063214A1 (de) | 2005-07-14 |
CA2551231A1 (en) | 2005-07-14 |
SI1699440T1 (sl) | 2010-03-31 |
CN1917862A (zh) | 2007-02-21 |
JP4895821B2 (ja) | 2012-03-14 |
ES2336571T3 (es) | 2010-04-14 |
CY1110609T1 (el) | 2015-04-29 |
US20130320592A1 (en) | 2013-12-05 |
AU2004308653B2 (en) | 2009-09-03 |
AR046994A1 (es) | 2006-01-04 |
JP2007516998A (ja) | 2007-06-28 |
EP1699440A1 (de) | 2006-09-13 |
ATE447942T1 (de) | 2009-11-15 |
US11224576B2 (en) | 2022-01-18 |
PE20050814A1 (es) | 2005-11-10 |
AU2004308653A1 (en) | 2005-07-14 |
US20150164811A1 (en) | 2015-06-18 |
IL176296A0 (en) | 2006-10-05 |
PL1699440T3 (pl) | 2010-04-30 |
DE10361596A1 (de) | 2005-09-29 |
HK1099511A1 (en) | 2007-08-17 |
CN1917862B (zh) | 2011-08-03 |
US20170049706A1 (en) | 2017-02-23 |
DK1699440T3 (da) | 2010-03-29 |
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