UA96152C2 - Dihydropyrazolopyrimidinone derivatives - Google Patents

Dihydropyrazolopyrimidinone derivatives

Info

Publication number
UA96152C2
UA96152C2 UAA200813667A UAA200813667A UA96152C2 UA 96152 C2 UA96152 C2 UA 96152C2 UA A200813667 A UAA200813667 A UA A200813667A UA A200813667 A UAA200813667 A UA A200813667A UA 96152 C2 UA96152 C2 UA 96152C2
Authority
UA
Ukraine
Prior art keywords
group
ris
compounds
lower alkyl
alkyl group
Prior art date
Application number
UAA200813667A
Other languages
English (en)
Ukrainian (uk)
Inventor
Тосихиро Сакамото
Сатоси Сунами
Фуюки Ямамото
Кендзи Ниияма
Макото Бамба
Кейдзи Такахаси
Хидетомо Фуруяма
Такеси Сагара
Сатие Отсуки
Тосихиде Нисибата
Такаси Йосизуми
Хироси Хираи
Original Assignee
Мсд К.К.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38655640&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=UA96152(C2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Мсд К.К. filed Critical Мсд К.К.
Publication of UA96152C2 publication Critical patent/UA96152C2/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4162—1,2-Diazoles condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Изобретение касается соединений общей формулы (I), в которых: Авыбирается из приведенной в описании формулы (aa1); Rпредставляет собой низшую алкенильную группу или низшую алкинильную группу; Rпредставляет собой фенильную, пиридильную или тиенильную группу; Rи Rпредставляют собой атом водорода, низшую алкильную группу или гидроксилсодержащую низшую алкильную группу и др.Соединения изобретения имеют замечательный ингибирующее влияние на Well-киназу и вследствие этого применимые в области медицины, особенно при лечении разных злокачественных опухолей., (I), (аа1)
UAA200813667A 2006-04-27 2007-04-25 Dihydropyrazolopyrimidinone derivatives UA96152C2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2006124208 2006-04-27

Publications (1)

Publication Number Publication Date
UA96152C2 true UA96152C2 (en) 2011-10-10

Family

ID=38655640

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA200813667A UA96152C2 (en) 2006-04-27 2007-04-25 Dihydropyrazolopyrimidinone derivatives

Country Status (39)

Country Link
US (4) US7834019B2 (ru)
EP (2) EP2016080B1 (ru)
JP (2) JP4513919B2 (ru)
KR (1) KR101409161B1 (ru)
CN (1) CN101432284B (ru)
AR (1) AR060635A1 (ru)
AT (1) ATE475662T1 (ru)
AU (1) AU2007244185B2 (ru)
BR (1) BRPI0710081A2 (ru)
CA (1) CA2650119C (ru)
CR (1) CR10359A (ru)
CY (2) CY1111069T1 (ru)
DE (1) DE602007008085D1 (ru)
DK (2) DK2016080T3 (ru)
DO (1) DOP2007000084A (ru)
EC (1) ECSP088812A (ru)
ES (2) ES2609087T3 (ru)
GT (1) GT200800211A (ru)
HK (1) HK1132498A1 (ru)
HN (1) HN2008001532A (ru)
HR (2) HRP20100563T1 (ru)
HU (1) HUE032987T2 (ru)
IL (1) IL194367A (ru)
LT (1) LT2017278T (ru)
MA (1) MA30428B1 (ru)
MX (1) MX2008013063A (ru)
MY (1) MY145408A (ru)
NO (1) NO341617B1 (ru)
NZ (1) NZ571196A (ru)
PE (1) PE20080695A1 (ru)
PL (2) PL2016080T3 (ru)
PT (2) PT2016080E (ru)
RU (1) RU2437885C2 (ru)
SI (2) SI2016080T1 (ru)
SV (1) SV2009003060A (ru)
TW (1) TWI409262B (ru)
UA (1) UA96152C2 (ru)
WO (2) WO2007126122A1 (ru)
ZA (1) ZA200807748B (ru)

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