CY1118526T1 - Παραγωγα διϋδροπυραζολοπυριμιδινονης - Google Patents
Παραγωγα διϋδροπυραζολοπυριμιδινονηςInfo
- Publication number
- CY1118526T1 CY1118526T1 CY20171100129T CY171100129T CY1118526T1 CY 1118526 T1 CY1118526 T1 CY 1118526T1 CY 20171100129 T CY20171100129 T CY 20171100129T CY 171100129 T CY171100129 T CY 171100129T CY 1118526 T1 CY1118526 T1 CY 1118526T1
- Authority
- CY
- Cyprus
- Prior art keywords
- group
- compounds
- dydropyrozolopyrimininone
- products
- lower alkyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/4162—1,2-Diazoles condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Η εφεύρεση σχετίζεται με ενώσεις ενός γενικού χημικού τύπου (I): όπου το Α1 επιλέγεται από τον ακόλουθο χημικό τύπο (aa1)· το R1 είναι ομάδα κατώτερου αλκενυλίου ή ομάδα κατώτερου αλκυνυλίου· το R2 είναι ομάδα φαινυλίου, πυριδυλίου ή θειενυλίου· τα R5 και R6 είναι άτομο υδρογόνου, ομάδα κατώτερου αλκυλίου ή ομάδα υδροξυ- κατώτερου αλκυλίου, κλπ. Οι ενώσεις της εφεύρεσης έχουν εξαιρετική ανασταλτική επίδραση της κινάσης Weel και είναι επομένως χρήσιμες στο πεδίο των φαρμάκων, ιδιαίτερα στην αγωγή διαφόρων καρκίνων.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2006124208 | 2006-04-27 | ||
PCT/JP2007/059416 WO2007126128A1 (ja) | 2006-04-27 | 2007-04-25 | ジヒドロピラゾロピリミジノン誘導体 |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1118526T1 true CY1118526T1 (el) | 2017-07-12 |
Family
ID=38655640
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20101100973T CY1111069T1 (el) | 2006-04-27 | 2010-10-27 | Παραγωγα διυδροπυραζολοπυριμιδινονης |
CY20171100129T CY1118526T1 (el) | 2006-04-27 | 2017-01-27 | Παραγωγα διϋδροπυραζολοπυριμιδινονης |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20101100973T CY1111069T1 (el) | 2006-04-27 | 2010-10-27 | Παραγωγα διυδροπυραζολοπυριμιδινονης |
Country Status (39)
Country | Link |
---|---|
US (4) | US7834019B2 (el) |
EP (2) | EP2017278B1 (el) |
JP (2) | JP4513919B2 (el) |
KR (1) | KR101409161B1 (el) |
CN (1) | CN101432284B (el) |
AR (1) | AR060635A1 (el) |
AT (1) | ATE475662T1 (el) |
AU (1) | AU2007244185B2 (el) |
BR (1) | BRPI0710081A2 (el) |
CA (1) | CA2650119C (el) |
CR (1) | CR10359A (el) |
CY (2) | CY1111069T1 (el) |
DE (1) | DE602007008085D1 (el) |
DK (2) | DK2017278T3 (el) |
DO (1) | DOP2007000084A (el) |
EC (1) | ECSP088812A (el) |
ES (2) | ES2348751T3 (el) |
GT (1) | GT200800211A (el) |
HK (1) | HK1132498A1 (el) |
HN (1) | HN2008001532A (el) |
HR (2) | HRP20100563T1 (el) |
HU (1) | HUE032987T2 (el) |
IL (1) | IL194367A (el) |
LT (1) | LT2017278T (el) |
MA (1) | MA30428B1 (el) |
MX (1) | MX2008013063A (el) |
MY (1) | MY145408A (el) |
NO (1) | NO341617B1 (el) |
NZ (1) | NZ571196A (el) |
PE (1) | PE20080695A1 (el) |
PL (2) | PL2017278T3 (el) |
PT (2) | PT2016080E (el) |
RU (1) | RU2437885C2 (el) |
SI (2) | SI2017278T1 (el) |
SV (1) | SV2009003060A (el) |
TW (1) | TWI409262B (el) |
UA (1) | UA96152C2 (el) |
WO (2) | WO2007126122A1 (el) |
ZA (1) | ZA200807748B (el) |
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AU2009325400A1 (en) * | 2008-12-12 | 2010-06-17 | Msd K.K. | Dihydropyrimidopyrimidine derivatives |
WO2010076887A1 (en) * | 2009-01-05 | 2010-07-08 | Banyu Pharmaceutical Co.,Ltd. | Predictive biomarkers useful for cancer therapy mediated by a wee1 inhibitor |
WO2010098367A1 (en) * | 2009-02-25 | 2010-09-02 | Banyu Pharmaceutical Co.,Ltd. | Pyrimidopyrimidoindazole derivative |
WO2011027800A1 (en) * | 2009-09-02 | 2011-03-10 | Banyu Pharmaceutical Co.,Ltd. | Use of biomarker(s) to identify a wee1 inhibitor responsive patient and methods of treating cancer mediated by dysfunctional or aberrant p53 via administration of a wee1 inhibitor |
SI2477628T1 (sl) | 2009-09-15 | 2014-11-28 | Merck Sharp & Dohme Corp. | Priprava oblik kristalinskega hemihidrata dihidropirazolopirimidinona |
RU2017127088A (ru) | 2010-11-16 | 2019-02-04 | Эррэй Биофарма Инк. | Комбинация ингибиторов чекпойнт-киназы 1 и ингибиторов киназы wee 1 |
US9207360B2 (en) * | 2011-04-27 | 2015-12-08 | Zeno Corporation | Polymerizable compound, polymerizable composition, polymer, and optically anisotropic body |
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CN115073460B (zh) * | 2022-07-13 | 2023-07-25 | 苏州施安鼎泰生物医药技术有限公司 | 一种嘧啶并[5,4-c][2,6]萘啶衍生物及其制备方法以及药物组合物和应用 |
TW202404977A (zh) * | 2022-07-15 | 2024-02-01 | 大陸商映恩生物製藥(蘇州)有限公司 | 一種嘧啶并五員雜環化合物、其製備方法和用途 |
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