CY1113812T1 - Ετεροκυκλικη ενωση και φαρμακευτικη συνθεση αυτης - Google Patents
Ετεροκυκλικη ενωση και φαρμακευτικη συνθεση αυτηςInfo
- Publication number
- CY1113812T1 CY1113812T1 CY20121100896T CY121100896T CY1113812T1 CY 1113812 T1 CY1113812 T1 CY 1113812T1 CY 20121100896 T CY20121100896 T CY 20121100896T CY 121100896 T CY121100896 T CY 121100896T CY 1113812 T1 CY1113812 T1 CY 1113812T1
- Authority
- CY
- Cyprus
- Prior art keywords
- group
- hydrogen atom
- heterocyclic
- heterocyclic ring
- hydrocyclic
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Physical Education & Sports Medicine (AREA)
- Ophthalmology & Optometry (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Urology & Nephrology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pulmonology (AREA)
- Hematology (AREA)
- Pain & Pain Management (AREA)
- Oncology (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Η παρούσα εφεύρεση παρέχει ετεροκυκλική ένωση που αντιπροσωπεύεται από το Γενικό Τύπο (1): όπου το R1 είναι μια ομάδα R5-Z1- κ.λπ., το Ζ1 είναι κατώτερη αλκυλένο ομάδα κ.λπ. και το R5 είναι μια ομάδα που αντιπροσωπεύεται από το Γενικό Τύπο: όπου το R13 είναι άτομο υδρογόνου κ.λπ., το m είναι ακέραιος από 1 έως 5, το R2 είναι άτομο υδρογόνου, το Υ είναι CH ή Ν, το Α1 είναι ετεροκυκλικός δακτύλιος επιλεγόμενος από την ομάδα που αποτελείται από ινδολοδιύλ ομάδες, όπου ο ετεροκυκλικός δακτύλιος μπορεί να έχει τουλάχιστον έναν υποκατάστατη, το Τ είναι μια ομάδα -CO- κ.λ.π., το R3 είναι άτομο υδρογόνου, το R4 είναι κατώτερη αλκύλ ομάδα προαιρετικώς υποκατεστημένη με μία ή περισσότερες υδρόξυ ομάδες κ.λπ., τα R3 και R4 μαζί με το άτομο αζώτου προς το οποίο συνδέονται, μπορεί να συνδέονται μεταξύ τους και να σχηματίζουν 5-μελή έως 10-μελή κορεσμένο ετεροκυκλικό δακτύλιο, όπου ο ετεροκυκλικός δακτύλιος μπορεί να έχει τουλάχιστον έναν υποκαταστάτη. Η ετεροκυκλική ένωση της παρούσας εφεύρεσης έχει εξαιρετικά αποτελέσματα καταστολής της παραγωγής κολλαγόνου ή/και θεραπείας όγκων.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2007281601 | 2007-10-30 | ||
| JP2007336157 | 2007-12-27 | ||
| EP08845000A EP2207773B1 (en) | 2007-10-30 | 2008-10-29 | Heterocyclic compound and pharmaceutical composition thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1113812T1 true CY1113812T1 (el) | 2016-07-27 |
Family
ID=40474791
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20121100896T CY1113812T1 (el) | 2007-10-30 | 2012-09-28 | Ετεροκυκλικη ενωση και φαρμακευτικη συνθεση αυτης |
Country Status (28)
| Country | Link |
|---|---|
| US (1) | US8551999B2 (el) |
| EP (1) | EP2207773B1 (el) |
| JP (1) | JP5236002B2 (el) |
| KR (1) | KR20100092469A (el) |
| CN (2) | CN103224488A (el) |
| AR (1) | AR069065A1 (el) |
| AU (1) | AU2008319719B2 (el) |
| BR (1) | BRPI0819232A2 (el) |
| CA (1) | CA2703240A1 (el) |
| CL (1) | CL2008003265A1 (el) |
| CO (1) | CO6210724A2 (el) |
| CY (1) | CY1113812T1 (el) |
| DK (1) | DK2207773T3 (el) |
| ES (1) | ES2390710T3 (el) |
| HR (1) | HRP20120748T1 (el) |
| IL (1) | IL204942A0 (el) |
| MX (1) | MX2010004893A (el) |
| MY (1) | MY148482A (el) |
| NZ (1) | NZ584573A (el) |
| PE (1) | PE20090949A1 (el) |
| PL (1) | PL2207773T3 (el) |
| PT (1) | PT2207773E (el) |
| RU (1) | RU2010121857A (el) |
| SI (1) | SI2207773T1 (el) |
| TW (1) | TWI440638B (el) |
| UA (1) | UA100248C2 (el) |
| WO (1) | WO2009057811A2 (el) |
| ZA (1) | ZA201002547B (el) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100927563B1 (ko) | 2004-08-06 | 2009-11-23 | 오쓰까 세이야꾸 가부시키가이샤 | 방향족 화합물 |
| ZA200804445B (en) * | 2005-12-05 | 2009-11-25 | Otsuka Pharma Co Ltd | Diarylether derivatives as antitumor agents |
| UA95978C2 (ru) * | 2006-10-02 | 2011-09-26 | Оцука Фармас'Ютікел Ко., Лтд. | Ингибитор активации stat3/5 |
| JO3265B1 (ar) | 2008-12-09 | 2018-09-16 | Novartis Ag | مثبطات بيريديلوكسى اندولات vegf-r2 واستخدامها لعلاج المرض |
| JP5688918B2 (ja) * | 2009-04-28 | 2015-03-25 | 大塚製薬株式会社 | 医薬組成物 |
| CN105153188B (zh) | 2009-10-22 | 2018-06-01 | 法博太科制药有限公司 | 抗纤维化剂的稠环类似物 |
| AU2011211306B2 (en) * | 2010-01-29 | 2016-07-07 | Otsuka Pharmaceutical Co., Ltd. | Di - substituted pyridine derivatives as anticancers |
| US9040555B2 (en) | 2012-01-26 | 2015-05-26 | Angion Biomedica Corp. | Antifibrotic compounds and uses thereof |
| WO2013130958A1 (en) | 2012-03-01 | 2013-09-06 | Allergan, Inc. | Benzofuran-2-sulfonamides derivatives as chemokine receptor modulators |
| AR094929A1 (es) | 2013-02-28 | 2015-09-09 | Bristol Myers Squibb Co | Derivados de fenilpirazol como inhibidores potentes de rock1 y rock2 |
| US9828345B2 (en) | 2013-02-28 | 2017-11-28 | Bristol-Myers Squibb Company | Phenylpyrazole derivatives as potent ROCK1 and ROCK2 inhibitors |
| SG11201907139UA (en) | 2017-02-03 | 2019-09-27 | Certa Therapeutics Pty Ltd | Anti-fibrotic compounds |
| CN108721621B (zh) * | 2017-04-14 | 2022-03-01 | 中国科学院上海高等研究院 | 抑制肝纤维化的小分子化合物及应用 |
| CN108033918B (zh) * | 2017-12-28 | 2020-12-25 | 西安欧得光电材料有限公司 | 一种光电材料中间体2-氯-4-苯基苯并[h]喹唑啉的合成方法 |
| CN112300145B (zh) * | 2019-07-31 | 2023-07-21 | 上海宇耀生物科技有限公司 | 一类靶向stat3双功能磷酸化位点的三芳香环类化合物及其应用 |
| JP2023175057A (ja) * | 2020-10-29 | 2023-12-12 | クミアイ化学工業株式会社 | 縮合ヘテロ環誘導体及びそれを有効成分として含有する除草剤 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR015733A1 (es) | 1998-03-25 | 2001-05-16 | Otsuka Pharma Co Ltd | DERIVADO DE PIRIDINA, EL PRODUCTO Y LA COMPOSICIoN FARMACEUTICA QUE CONTIENE DICHO DERIVADO. |
| JP2001089450A (ja) | 1999-09-22 | 2001-04-03 | Otsuka Pharmaceut Co Ltd | ピリジン誘導体含有医薬製剤 |
| JP2001089412A (ja) * | 1999-09-22 | 2001-04-03 | Otsuka Pharmaceut Co Ltd | ベンゼン誘導体またはその医薬的に許容される塩 |
| ATE399766T1 (de) * | 2000-10-20 | 2008-07-15 | Eisai R&D Man Co Ltd | Stickstoff enthaltende aromatische heterozyklen |
-
2008
- 2008-10-22 TW TW097140442A patent/TWI440638B/zh not_active IP Right Cessation
- 2008-10-28 AR ARP080104696A patent/AR069065A1/es unknown
- 2008-10-29 ES ES08845000T patent/ES2390710T3/es active Active
- 2008-10-29 PE PE2008001846A patent/PE20090949A1/es not_active Application Discontinuation
- 2008-10-29 CN CN2013100900890A patent/CN103224488A/zh active Pending
- 2008-10-29 NZ NZ584573A patent/NZ584573A/en not_active IP Right Cessation
- 2008-10-29 CN CN200880114249A patent/CN101842367A/zh active Pending
- 2008-10-29 EP EP08845000A patent/EP2207773B1/en not_active Not-in-force
- 2008-10-29 JP JP2010530682A patent/JP5236002B2/ja not_active Expired - Fee Related
- 2008-10-29 KR KR1020107011932A patent/KR20100092469A/ko not_active Application Discontinuation
- 2008-10-29 MX MX2010004893A patent/MX2010004893A/es active IP Right Grant
- 2008-10-29 CA CA2703240A patent/CA2703240A1/en not_active Abandoned
- 2008-10-29 MY MYPI2010001885A patent/MY148482A/en unknown
- 2008-10-29 DK DK08845000.2T patent/DK2207773T3/da active
- 2008-10-29 WO PCT/JP2008/070153 patent/WO2009057811A2/en active Application Filing
- 2008-10-29 US US12/740,684 patent/US8551999B2/en not_active Expired - Fee Related
- 2008-10-29 PT PT08845000T patent/PT2207773E/pt unknown
- 2008-10-29 RU RU2010121857/04A patent/RU2010121857A/ru unknown
- 2008-10-29 UA UAA201006444 patent/UA100248C2/xx unknown
- 2008-10-29 PL PL08845000T patent/PL2207773T3/pl unknown
- 2008-10-29 AU AU2008319719A patent/AU2008319719B2/en not_active Ceased
- 2008-10-29 BR BRPI0819232A patent/BRPI0819232A2/pt not_active IP Right Cessation
- 2008-10-29 SI SI200830740T patent/SI2207773T1/sl unknown
- 2008-10-30 CL CL2008003265A patent/CL2008003265A1/es unknown
-
2010
- 2010-04-08 IL IL204942A patent/IL204942A0/en unknown
- 2010-04-12 ZA ZA2010/02547A patent/ZA201002547B/en unknown
- 2010-05-14 CO CO10057752A patent/CO6210724A2/es active IP Right Grant
-
2012
- 2012-09-20 HR HRP20120748AT patent/HRP20120748T1/hr unknown
- 2012-09-28 CY CY20121100896T patent/CY1113812T1/el unknown
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