CY1113486T1 - Συντηγμενες δικυκλικες πυριμιδινες - Google Patents

Συντηγμενες δικυκλικες πυριμιδινες

Info

Publication number
CY1113486T1
CY1113486T1 CY20121101220T CY121101220T CY1113486T1 CY 1113486 T1 CY1113486 T1 CY 1113486T1 CY 20121101220 T CY20121101220 T CY 20121101220T CY 121101220 T CY121101220 T CY 121101220T CY 1113486 T1 CY1113486 T1 CY 1113486T1
Authority
CY
Cyprus
Prior art keywords
pyramides
signed
bicycle
pi3k
tautomer
Prior art date
Application number
CY20121101220T
Other languages
English (en)
Inventor
Swen HÖLDER
Matthias Vennemann
Gerrit Beneke
Armin Zülch
Volker Gekeler
Thomas Beckers
Astrid Zimmermann
Hemant Joshi
Original Assignee
Bayer Intellectual Property Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP07118736A external-priority patent/EP2050748A1/en
Application filed by Bayer Intellectual Property Gmbh filed Critical Bayer Intellectual Property Gmbh
Publication of CY1113486T1 publication Critical patent/CY1113486T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

Abstract

Ενώσεις του τύπου (I), ένα ταυτομερές ή στερεοϊσομερές αυτής, ή ένα άλας αυτής, όπου ο δακτύλιος Β και η πυριμιδίνη με την οποία συνενώνεται, τα R4, R5, R6 και R7 έχουν τις έννοιες που δίνονται στην περιγραφή και τις αξιώσεις, είναι αποτελεσματικοί αναστολείς της οδού Pi3K/Akt.
CY20121101220T 2007-08-14 2012-12-13 Συντηγμενες δικυκλικες πυριμιδινες CY1113486T1 (el)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IN1572MU2007 2007-08-14
EP07118736A EP2050748A1 (en) 2007-10-18 2007-10-18 Novel fused pyrimidines
EP08787224A EP2188291B1 (en) 2007-08-14 2008-08-14 Fused bicyclic pyrimidines

Publications (1)

Publication Number Publication Date
CY1113486T1 true CY1113486T1 (el) 2016-06-22

Family

ID=40153211

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20121101220T CY1113486T1 (el) 2007-08-14 2012-12-13 Συντηγμενες δικυκλικες πυριμιδινες

Country Status (38)

Country Link
US (2) US7776864B2 (el)
EP (1) EP2188291B1 (el)
JP (1) JP5344637B2 (el)
KR (1) KR20100053556A (el)
CN (1) CN101778851B (el)
AR (1) AR067945A1 (el)
AU (1) AU2008288392B2 (el)
BR (1) BRPI0815207A2 (el)
CA (1) CA2694058C (el)
CL (1) CL2008002398A1 (el)
CO (1) CO6260077A2 (el)
CR (1) CR11270A (el)
CY (1) CY1113486T1 (el)
DK (1) DK2188291T3 (el)
DO (1) DOP2010000058A (el)
EA (1) EA020996B1 (el)
EC (1) ECSP109964A (el)
ES (1) ES2396177T3 (el)
HK (1) HK1146273A1 (el)
HN (1) HN2010000313A (el)
HR (1) HRP20121022T1 (el)
IL (1) IL203163A (el)
MA (1) MA31608B1 (el)
MX (1) MX2010001746A (el)
MY (1) MY169738A (el)
NZ (1) NZ583267A (el)
PA (1) PA8793201A1 (el)
PE (1) PE20090944A1 (el)
PL (1) PL2188291T3 (el)
PT (1) PT2188291E (el)
RS (1) RS52559B (el)
SI (1) SI2188291T1 (el)
SV (1) SV2010003483A (el)
TN (1) TN2010000070A1 (el)
TW (1) TWI439272B (el)
UA (1) UA99735C2 (el)
UY (1) UY31293A1 (el)
WO (1) WO2009021992A2 (el)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0717722A2 (pt) * 2006-10-19 2013-10-29 Takeda Pharmaceutical Composto ou um sal do mesmo, pró-droga, ativador de glicoquinase, agente farmacêutico, métodos para ativar uma glicoquinase em um mamífero e para a profilaxia ou o tratamento de diabetes ou obesidade em um mamífero, e, uso do composto ou uma pró-droga do mesmo
ES2396177T3 (es) 2007-08-14 2013-02-19 Bayer Intellectual Property Gmbh Pirimidinas bicíclicas fusionadas
AU2009260447B2 (en) 2008-05-30 2012-03-29 Amgen Inc. Inhibitors of PI3 kinase
EP2396331B1 (en) * 2009-02-13 2013-10-16 Bayer Intellectual Property GmbH Fused pyrimidines as akt inhibitors
MX2011008583A (es) 2009-02-13 2011-12-12 Bayer Pharma AG Pirimidinas fusionadas.
US8691825B2 (en) 2009-04-01 2014-04-08 Merck Sharp & Dohme Corp. Inhibitors of AKT activity
US20120071475A1 (en) 2009-04-27 2012-03-22 Shionogi & Co., Ltd. Urea derivatives having pi3k-inhibiting activity
US20130184273A1 (en) * 2010-07-13 2013-07-18 Bayer Intellectual Property Gmbh Bicyclic pyrimidines
WO2012013713A2 (en) 2010-07-28 2012-02-02 Bayer Pharma Aktiengesellschaft Substituted imidazo[1,2-b]pyridazines
RS54480B1 (en) 2011-04-07 2016-06-30 Bayer Intellectual Property Gmbh IMIDAZOPYRIDASINE AS ACT KINASE INHIBITORS
WO2014114928A1 (en) 2013-01-23 2014-07-31 Astrazeneca Ab Chemical compounds
EP2967030A2 (en) * 2013-03-15 2016-01-20 Bayer CropScience LP Compositions, additives, and methods for mitigating or controlling seed dust
US20140274685A1 (en) 2013-03-15 2014-09-18 Bayer Cropscience Lp Compositions, additives, and methods for mitigating or controlling seed dust
TW201920185A (zh) 2017-09-15 2019-06-01 美商艾杜諾生物科技公司 吡唑并嘧啶酮化合物及其用途

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002002563A2 (en) 2000-06-30 2002-01-10 Wyeth Substituted-triazolopyrimidines as anticancer agents
US7449488B2 (en) * 2002-06-04 2008-11-11 Schering Corporation Pyrazolopyrimidines as protein kinase inhibitors
US7579355B2 (en) 2003-04-24 2009-08-25 Merck & Co., Inc. Inhibitors of Akt activity
CN1942465A (zh) 2004-04-09 2007-04-04 默克公司 Akt活性抑制剂
TW200618800A (en) * 2004-08-03 2006-06-16 Uriach Y Compania S A J Heterocyclic compounds
EP1784175A4 (en) 2004-08-23 2009-07-22 Merck & Co Inc INHIBITORS OF ACT ACTIVITY
EP1827436A4 (en) 2004-12-15 2011-08-10 Merck Sharp & Dohme ACTIVITY INHIBITORS AKT
ATE543821T1 (de) * 2004-12-28 2012-02-15 Exelixis Inc Ä1h-pyrazoloä3,4-düpyrimidin-4-ylü-piperidin- oder piperazinverbindungen als serin-threonin- kinasemodulatoren (p70s6k, atk1 und atk2) zur behandlung von immunologischen, entzündlichen und proliferativen erkrankungen
US7589068B2 (en) 2005-02-14 2009-09-15 Merck & Co., Inc. Inhibitors of Akt activity
BRPI0611717A2 (pt) 2005-06-10 2009-01-13 Merck & Co Inc composto, composiÇço farmacÊutica e uso do composto
ES2396177T3 (es) 2007-08-14 2013-02-19 Bayer Intellectual Property Gmbh Pirimidinas bicíclicas fusionadas
MX2011008583A (es) * 2009-02-13 2011-12-12 Bayer Pharma AG Pirimidinas fusionadas.

Also Published As

Publication number Publication date
ECSP109964A (es) 2010-03-31
KR20100053556A (ko) 2010-05-20
DOP2010000058A (es) 2010-02-28
TWI439272B (zh) 2014-06-01
HN2010000313A (es) 2013-03-18
CN101778851B (zh) 2013-05-08
NZ583267A (en) 2012-03-30
HRP20121022T1 (hr) 2013-01-31
EA020996B1 (ru) 2015-03-31
CN101778851A (zh) 2010-07-14
PE20090944A1 (es) 2009-08-09
IL203163A (en) 2015-01-29
CR11270A (es) 2010-05-19
CA2694058C (en) 2016-06-07
UA99735C2 (uk) 2012-09-25
AU2008288392B2 (en) 2013-10-24
WO2009021992A3 (en) 2009-04-16
PA8793201A1 (es) 2009-04-23
EP2188291B1 (en) 2012-09-19
CL2008002398A1 (es) 2009-07-31
MA31608B1 (fr) 2010-08-02
TW200922592A (en) 2009-06-01
AU2008288392A1 (en) 2009-02-19
ES2396177T3 (es) 2013-02-19
JP2010535848A (ja) 2010-11-25
BRPI0815207A2 (pt) 2017-03-28
US7776864B2 (en) 2010-08-17
EA201000298A1 (ru) 2010-10-29
JP5344637B2 (ja) 2013-11-20
US20100184782A1 (en) 2010-07-22
WO2009021992A2 (en) 2009-02-19
PT2188291E (pt) 2012-12-20
SI2188291T1 (sl) 2013-01-31
CA2694058A1 (en) 2009-02-19
TN2010000070A1 (en) 2011-09-26
US8614218B2 (en) 2013-12-24
HK1146273A1 (en) 2011-05-20
SV2010003483A (es) 2010-07-06
AR067945A1 (es) 2009-10-28
PL2188291T3 (pl) 2013-06-28
MY169738A (en) 2019-05-14
EP2188291A2 (en) 2010-05-26
US20090137607A1 (en) 2009-05-28
RS52559B (en) 2013-04-30
MX2010001746A (es) 2010-03-10
UY31293A1 (es) 2009-03-31
CO6260077A2 (es) 2011-03-22
DK2188291T3 (da) 2013-01-07

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