MA31608B1 - Pyrimidines bicycliques condensees - Google Patents

Pyrimidines bicycliques condensees

Info

Publication number
MA31608B1
MA31608B1 MA32617A MA32617A MA31608B1 MA 31608 B1 MA31608 B1 MA 31608B1 MA 32617 A MA32617 A MA 32617A MA 32617 A MA32617 A MA 32617A MA 31608 B1 MA31608 B1 MA 31608B1
Authority
MA
Morocco
Prior art keywords
condensed bicyclic
bicyclic pyrimidines
pyrimidines
condensed
compounds
Prior art date
Application number
MA32617A
Other languages
English (en)
Inventor
Swen Hoelder
Matthias Vennemann
Gerrit Beneke
Armin Zuelch
Volker Gekeler
Thomas Beckers
Astrid Zimmermann
Hemant Joshi
Original Assignee
Bayer Schering Pharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP07118736A external-priority patent/EP2050748A1/fr
Application filed by Bayer Schering Pharma Ag filed Critical Bayer Schering Pharma Ag
Publication of MA31608B1 publication Critical patent/MA31608B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

L'INVENTION PORTE SUR DES COMPOSÉS DE LA FORMULE (I), SUR UN TAUTOMÈRE OU UN STÉRÉOISOMÈRE DE CES DERNIERS, OU SUR UN SEL DE CES DERNIERS, DANS LAQUELLE LE CYCLE B ET LA PYRIMIDINE AVEC LAQUELLE IL EST CONDENSÉ, R4, R5, R6 ET R7 SONT TELS QUE DÉFINIS DANS LA DESCRIPTION ET LES REVENDICATIONS, LESQUELS COMPOSÉS SONT DES INHIBITEURS EFFICACES DE LA VOIE PI3K/AKT.
MA32617A 2007-08-14 2010-02-12 Pyrimidines bicycliques condensees MA31608B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN1572MU2007 2007-08-14
EP07118736A EP2050748A1 (fr) 2007-10-18 2007-10-18 Nouveau pyrimidines fusionnés

Publications (1)

Publication Number Publication Date
MA31608B1 true MA31608B1 (fr) 2010-08-02

Family

ID=40153211

Family Applications (1)

Application Number Title Priority Date Filing Date
MA32617A MA31608B1 (fr) 2007-08-14 2010-02-12 Pyrimidines bicycliques condensees

Country Status (38)

Country Link
US (2) US7776864B2 (fr)
EP (1) EP2188291B1 (fr)
JP (1) JP5344637B2 (fr)
KR (1) KR20100053556A (fr)
CN (1) CN101778851B (fr)
AR (1) AR067945A1 (fr)
AU (1) AU2008288392B2 (fr)
BR (1) BRPI0815207A2 (fr)
CA (1) CA2694058C (fr)
CL (1) CL2008002398A1 (fr)
CO (1) CO6260077A2 (fr)
CR (1) CR11270A (fr)
CY (1) CY1113486T1 (fr)
DK (1) DK2188291T3 (fr)
DO (1) DOP2010000058A (fr)
EA (1) EA020996B1 (fr)
EC (1) ECSP109964A (fr)
ES (1) ES2396177T3 (fr)
HK (1) HK1146273A1 (fr)
HN (1) HN2010000313A (fr)
HR (1) HRP20121022T1 (fr)
IL (1) IL203163A (fr)
MA (1) MA31608B1 (fr)
MX (1) MX2010001746A (fr)
MY (1) MY169738A (fr)
NZ (1) NZ583267A (fr)
PA (1) PA8793201A1 (fr)
PE (1) PE20090944A1 (fr)
PL (1) PL2188291T3 (fr)
PT (1) PT2188291E (fr)
RS (1) RS52559B (fr)
SI (1) SI2188291T1 (fr)
SV (1) SV2010003483A (fr)
TN (1) TN2010000070A1 (fr)
TW (1) TWI439272B (fr)
UA (1) UA99735C2 (fr)
UY (1) UY31293A1 (fr)
WO (1) WO2009021992A2 (fr)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7652133B2 (en) * 2006-10-19 2010-01-26 Takeda Pharmaceutical Company Limited Indole compound
PE20090944A1 (es) 2007-08-14 2009-08-09 Bayer Schering Pharma Ag PIRIMIDINAS BICICLICAS FUSIONADAS COMO INHIBIDORES DE LA VIA Pi3K/AKT
WO2009155121A2 (fr) 2008-05-30 2009-12-23 Amgen Inc. Inhibiteurs de la pi3 kinase
EP2396331B1 (fr) * 2009-02-13 2013-10-16 Bayer Intellectual Property GmbH Pyrimidines condensées en tant qu'inhibiteurs d'akt
PE20120534A1 (es) 2009-02-13 2012-05-10 Bayer Pharma AG PIRIMIDINAS FUSIONADAS COMO INHIBIDORES DE Akt
US8691825B2 (en) 2009-04-01 2014-04-08 Merck Sharp & Dohme Corp. Inhibitors of AKT activity
TW201103943A (en) 2009-04-27 2011-02-01 Shionogi & Co Urea derivative having pi3k inhibitory activity
JP2013530250A (ja) * 2010-07-13 2013-07-25 バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング 二環式ピリミジン化合物
US8987273B2 (en) 2010-07-28 2015-03-24 Bayer Intellectual Property Gmbh Substituted imidazo[1,2-B]pyridazines
EA024890B1 (ru) 2011-04-07 2016-10-31 Байер Интеллектчуал Проперти Гмбх Имидазопиридазины в качестве ингибиторов akt киназы
AU2014208964B2 (en) 2013-01-23 2016-09-01 Astrazeneca Ab Chemical compounds
US20160272861A1 (en) * 2013-03-15 2016-09-22 Bayer Cropscience Lp Compositions, additives, and methods for mitigating or controlling seed dust
US20140274685A1 (en) 2013-03-15 2014-09-18 Bayer Cropscience Lp Compositions, additives, and methods for mitigating or controlling seed dust
AU2018331456B2 (en) 2017-09-15 2020-10-08 Chinook Therapeutics, Inc. Pyrazolopyrimidinone compounds and uses thereof

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA02011913A (es) 2000-06-30 2003-04-22 Wyeth Corp Triazolopirimidinas sustituidas como agentes anticancer.
US7449488B2 (en) * 2002-06-04 2008-11-11 Schering Corporation Pyrazolopyrimidines as protein kinase inhibitors
AU2004233828B2 (en) 2003-04-24 2009-05-28 Merck Sharp & Dohme Corp. Inhibitors of Akt activity
EP1737843B1 (fr) 2004-04-09 2011-02-23 Merck Sharp & Dohme Corp. Inhibiteurs de l'activite d'akt
TW200618800A (en) * 2004-08-03 2006-06-16 Uriach Y Compania S A J Heterocyclic compounds
US7544677B2 (en) 2004-08-23 2009-06-09 Merck & Co., Inc. Inhibitors of Akt activity
CA2589084A1 (fr) 2004-12-15 2006-06-22 Merck & Co., Inc. Inhibiteurs d'activite akt
US7994172B2 (en) * 2004-12-28 2011-08-09 Exelixis, Inc. [1H-pyrazolo[3, 4-D]pyrimidin-4-yl]-piperidine or -piperazine compounds as serine-theoronine kinase modulators (P70s6k, Atk1 and Atk2) for the treatment of immunological, inflammatory and proliferative diseases
US7589068B2 (en) 2005-02-14 2009-09-15 Merck & Co., Inc. Inhibitors of Akt activity
ES2409168T3 (es) 2005-06-10 2013-06-25 Merck Sharp & Dohme Corp. Inhibidores de la actividad Akt
PE20090944A1 (es) 2007-08-14 2009-08-09 Bayer Schering Pharma Ag PIRIMIDINAS BICICLICAS FUSIONADAS COMO INHIBIDORES DE LA VIA Pi3K/AKT
PE20120534A1 (es) * 2009-02-13 2012-05-10 Bayer Pharma AG PIRIMIDINAS FUSIONADAS COMO INHIBIDORES DE Akt

Also Published As

Publication number Publication date
PT2188291E (pt) 2012-12-20
PA8793201A1 (es) 2009-04-23
IL203163A (en) 2015-01-29
CO6260077A2 (es) 2011-03-22
RS52559B (en) 2013-04-30
CY1113486T1 (el) 2016-06-22
US20100184782A1 (en) 2010-07-22
CA2694058C (fr) 2016-06-07
HRP20121022T1 (hr) 2013-01-31
MY169738A (en) 2019-05-14
EA020996B1 (ru) 2015-03-31
AU2008288392B2 (en) 2013-10-24
AR067945A1 (es) 2009-10-28
DK2188291T3 (da) 2013-01-07
CN101778851A (zh) 2010-07-14
HK1146273A1 (en) 2011-05-20
TN2010000070A1 (en) 2011-09-26
CL2008002398A1 (es) 2009-07-31
MX2010001746A (es) 2010-03-10
UA99735C2 (uk) 2012-09-25
ECSP109964A (es) 2010-03-31
JP2010535848A (ja) 2010-11-25
CA2694058A1 (fr) 2009-02-19
NZ583267A (en) 2012-03-30
JP5344637B2 (ja) 2013-11-20
US8614218B2 (en) 2013-12-24
CR11270A (es) 2010-05-19
EP2188291A2 (fr) 2010-05-26
AU2008288392A1 (en) 2009-02-19
TWI439272B (zh) 2014-06-01
PL2188291T3 (pl) 2013-06-28
PE20090944A1 (es) 2009-08-09
DOP2010000058A (es) 2010-02-28
EP2188291B1 (fr) 2012-09-19
US7776864B2 (en) 2010-08-17
WO2009021992A3 (fr) 2009-04-16
ES2396177T3 (es) 2013-02-19
WO2009021992A2 (fr) 2009-02-19
SV2010003483A (es) 2010-07-06
EA201000298A1 (ru) 2010-10-29
HN2010000313A (es) 2013-03-18
US20090137607A1 (en) 2009-05-28
CN101778851B (zh) 2013-05-08
KR20100053556A (ko) 2010-05-20
UY31293A1 (es) 2009-03-31
BRPI0815207A2 (pt) 2017-03-28
TW200922592A (en) 2009-06-01
SI2188291T1 (sl) 2013-01-31

Similar Documents

Publication Publication Date Title
MA31608B1 (fr) Pyrimidines bicycliques condensees
MA33032B1 (fr) Pyrimidines condensees
MA31158B1 (fr) Composes tricycliques et leur utilisation comme modulateurs du recepteur de glucocorticoïdes
EA201000297A1 (ru) Конденсированные бициклические имидазолы
MA34392B1 (fr) Pyrimidines en tant qu'agents antiviraux
EA200970575A1 (ru) Соединения на основе 4-фенил-6-(2,2,2-трифтор-1-фенилэтокси)пиримидина и способы их применения
EA201071264A1 (ru) Аминодигидротиазиновые производные в качестве ингибиторов bace для лечения болезни альцгеймера
MA32711B1 (fr) Pyrrolidine-2-carboxamides substitues
MA32904B1 (fr) Composes de purine
MX2009009590A (es) Aminopirimidinas utiles como inhibidores de proteinas cinasas.
EA200700047A1 (ru) Новые алкильные производные в качестве метаботропных рецепторов глутамата
JO2355B1 (en) Hereditary calcitonin polypeptide receptor antagonists
MA31741B1 (fr) Derives fongicides de 2-alkylthio-2-quinolinyloxy- acetamide
EA200700909A1 (ru) Азаиндолкарбоксамиды
EA201500403A1 (ru) Соединения, активирующие теломеразу, и способы их применения
MA38315A1 (fr) Composés tétracycliques substitués par un hétérocycle et procédés pour les utiliser pour le traitement de maladies virales
CR8184A (es) Pirimidinas 2-sustituidas
DK1696905T3 (da) Substituerede 2-aminotetraliner til forebyggende behandling af Morbus Parkinson
MX2009011059A (es) Aminopirimidinas utiles como inhibidores de cinasas.
EA201070599A1 (ru) Ингибиторы равновесного переносчика нуклеозидов ent1
EA201170828A1 (ru) Конденсированные гетероциклические производные оксадиазола, подходящие для лечения рассеянного склероза
DE602007011434D1 (de) 1h-indol-5-ylpiperazin-1-ylmethanonderivate
MA34098B1 (fr) Utilisation de nouveaux inhibiteurs pan-cdk pour le traitement de tumeurs
MA32985B1 (fr) Nouveaux microbiocides
SG10201902903RA (en) Synthesis and novel salt forms of (r)-5-((e)-2-(pyrrolidin-3-ylvinyl)pyrimidine