EA201070599A1 - Ингибиторы равновесного переносчика нуклеозидов ent1 - Google Patents

Ингибиторы равновесного переносчика нуклеозидов ent1

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Publication number
EA201070599A1
EA201070599A1 EA201070599A EA201070599A EA201070599A1 EA 201070599 A1 EA201070599 A1 EA 201070599A1 EA 201070599 A EA201070599 A EA 201070599A EA 201070599 A EA201070599 A EA 201070599A EA 201070599 A1 EA201070599 A1 EA 201070599A1
Authority
EA
Eurasian Patent Office
Prior art keywords
ent1
equilibrium
nucleoosid
inhibitors
transfer
Prior art date
Application number
EA201070599A
Other languages
English (en)
Other versions
EA017215B1 (ru
Inventor
Жан-Поль Рене Мари Андре Босман
Дидье Жан-Код Бертело
Серж Мария Алоисиус Питерс
Би Мария Питер Вербист
Михел Анна Йозеф Де Клейн
Original Assignee
Янссен Фармацевтика Нв
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Янссен Фармацевтика Нв filed Critical Янссен Фармацевтика Нв
Publication of EA201070599A1 publication Critical patent/EA201070599A1/ru
Publication of EA017215B1 publication Critical patent/EA017215B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems

Abstract

Настоящее изобретение относится к новым соединениям формулы (I), обладающим ингибирующими свойствами в отношении равновесного переносчика нуклеозида ENT1, фармацевтическим композициям, содержащим эти соединения, химическим способам получения этих соединений и их применению при лечении заболеваний, связанных с ингибированием рецепторов ENT1 у животных, особенно у людей.
EA201070599A 2007-11-14 2008-11-13 Ингибиторы равновесного переносчика нуклеозидов ent1 EA017215B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP07120630 2007-11-14
PCT/EP2008/065438 WO2009062990A2 (en) 2007-11-14 2008-11-13 Equilibrative nucleoside transporter ent1 inhibitors

Publications (2)

Publication Number Publication Date
EA201070599A1 true EA201070599A1 (ru) 2010-12-30
EA017215B1 EA017215B1 (ru) 2012-10-30

Family

ID=39145373

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201070599A EA017215B1 (ru) 2007-11-14 2008-11-13 Ингибиторы равновесного переносчика нуклеозидов ent1

Country Status (18)

Country Link
US (1) US8263592B2 (ru)
EP (1) EP2209790B1 (ru)
JP (1) JP5369108B2 (ru)
KR (1) KR101598136B1 (ru)
CN (1) CN101855224B (ru)
AR (1) AR069304A1 (ru)
AU (1) AU2008322960B2 (ru)
BR (1) BRPI0820642B1 (ru)
CA (1) CA2704423C (ru)
CL (1) CL2008003383A1 (ru)
EA (1) EA017215B1 (ru)
ES (1) ES2569511T3 (ru)
HK (1) HK1146722A1 (ru)
IL (1) IL205710A (ru)
JO (1) JO3126B1 (ru)
PA (1) PA8803401A1 (ru)
TW (1) TWI437000B (ru)
WO (1) WO2009062990A2 (ru)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201101959D0 (en) 2011-02-04 2011-03-23 Univ Nottingham Novel ether linked compoundsand improved treatments for cardiac and cardiovascular disease
AU2015279377B2 (en) 2014-06-26 2019-09-12 F. Hoffmann-La Roche Ag Indolin-2-one or pyrrolo-pyridin-2-one derivatives
PE20181885A1 (es) 2015-11-06 2018-12-07 Hoffmann La Roche Derivados de indolin-2-ona
EP3371174B1 (en) * 2015-11-06 2021-03-17 H. Hoffnabb-La Roche Ag Indolin-2-one derivatives
CN108349942B (zh) 2015-11-06 2021-03-30 豪夫迈·罗氏有限公司 用于治疗cns和相关疾病的二氢吲哚-2-酮衍生物
CN105802999B (zh) * 2016-04-01 2019-05-03 中南大学湘雅医院 一种膜蛋白ENTs跨膜转运ODNs的试剂盒及方法
JP6879677B2 (ja) 2016-05-26 2021-06-02 株式会社クボタ 作業車
BR112019008516A2 (pt) 2016-11-14 2019-07-09 Jiangsu Hengrui Medicine Co derivado de 3,4-bipiridil pirazol, e método de preparação para o mesmo e aplicação médica do mesmo

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9701396D0 (sv) 1997-04-15 1997-04-15 Astra Pharma Prod Compounds
GB0003397D0 (en) * 2000-02-14 2000-04-05 Merck Sharp & Dohme Therapeutic agents
AU2003300124A1 (en) 2002-12-31 2004-07-29 BUOLAMWINI, John, K Novel nucleoside transport inhibitors
JPWO2004101593A1 (ja) * 2003-05-16 2006-07-13 キッセイ薬品工業株式会社 ５’−修飾ヌクレオシド誘導体及びその医薬用途
EP1698635B1 (en) * 2003-12-26 2011-12-14 Kissei Pharmaceutical Co., Ltd. Benzimidazole derivatives and medical uses thereof
WO2007011815A2 (en) * 2005-07-15 2007-01-25 Children's Hospital Medical Center Apparatus for minimally invasive posterior correction of spinal deformity
AR057570A1 (es) * 2005-11-14 2007-12-05 Solvay Pharm Gmbh Derivados de n-sulfamoil-n'-benzopiranopiperidinas espirocondensadas, composiciones farmaceuticas que los comprenden, un procedimiento para su preparacion y su uso en la preparacion de medicamentos para el tratamiento de enfermedades mediadas por las isoenzimas anhidrasas carbonicas subtipos ii y/o
US7576207B2 (en) * 2006-04-06 2009-08-18 Adolor Corporation Spirocyclic heterocyclic derivatives and methods of their use

Also Published As

Publication number Publication date
CA2704423A1 (en) 2009-05-22
AU2008322960A1 (en) 2009-05-22
IL205710A (en) 2013-07-31
CL2008003383A1 (es) 2010-02-05
KR20100089088A (ko) 2010-08-11
US8263592B2 (en) 2012-09-11
JP2011503147A (ja) 2011-01-27
ES2569511T3 (es) 2016-05-11
US20100280025A1 (en) 2010-11-04
BRPI0820642A2 (pt) 2020-08-11
EP2209790B1 (en) 2016-02-17
EA017215B1 (ru) 2012-10-30
JO3126B1 (ar) 2017-09-20
CA2704423C (en) 2017-01-10
WO2009062990A3 (en) 2009-09-24
KR101598136B1 (ko) 2016-02-29
AU2008322960B2 (en) 2013-02-07
EP2209790A2 (en) 2010-07-28
IL205710A0 (en) 2010-11-30
TW200936593A (en) 2009-09-01
WO2009062990A2 (en) 2009-05-22
PA8803401A1 (es) 2009-06-23
AR069304A1 (es) 2010-01-13
JP5369108B2 (ja) 2013-12-18
CN101855224B (zh) 2012-11-28
TWI437000B (zh) 2014-05-11
BRPI0820642B1 (pt) 2021-05-25
CN101855224A (zh) 2010-10-06
HK1146722A1 (en) 2011-07-08

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MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM