ECSP109964A - Pirimidinas bicíclicas fusionadas - Google Patents

Pirimidinas bicíclicas fusionadas

Info

Publication number
ECSP109964A
ECSP109964A EC2010009964A ECSP109964A ECSP109964A EC SP109964 A ECSP109964 A EC SP109964A EC 2010009964 A EC2010009964 A EC 2010009964A EC SP109964 A ECSP109964 A EC SP109964A EC SP109964 A ECSP109964 A EC SP109964A
Authority
EC
Ecuador
Prior art keywords
fusioned
pyrimidins
bicyclic
pi3k
tautomers
Prior art date
Application number
EC2010009964A
Other languages
English (en)
Inventor
Swen Hoelder
Matthias Vennemann
Gerrit Beneke
Armin Zuelch
Volker Gekeler
Thomas Beckers
Astrid Zimmermann
Hemant Joshi
Original Assignee
Bayer Schering Pharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP07118736A external-priority patent/EP2050748A1/en
Application filed by Bayer Schering Pharma Ag filed Critical Bayer Schering Pharma Ag
Publication of ECSP109964A publication Critical patent/ECSP109964A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Compuestos de fórmula (I), los tautómeros o los estereoisómeros de éstos, o las sales de éstos, donde el anillo B y la pirimidina a la que está fusionado, R4, R5, R6, y R7 tienen los valores indicados en la descripción y las reivindicaciones, y son inhibidores eficaces de la vía Pi3K/Akt.
EC2010009964A 2007-08-14 2010-02-12 Pirimidinas bicíclicas fusionadas ECSP109964A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN1572MU2007 2007-08-14
EP07118736A EP2050748A1 (en) 2007-10-18 2007-10-18 Novel fused pyrimidines

Publications (1)

Publication Number Publication Date
ECSP109964A true ECSP109964A (es) 2010-03-31

Family

ID=40153211

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2010009964A ECSP109964A (es) 2007-08-14 2010-02-12 Pirimidinas bicíclicas fusionadas

Country Status (38)

Country Link
US (2) US7776864B2 (es)
EP (1) EP2188291B1 (es)
JP (1) JP5344637B2 (es)
KR (1) KR20100053556A (es)
CN (1) CN101778851B (es)
AR (1) AR067945A1 (es)
AU (1) AU2008288392B2 (es)
BR (1) BRPI0815207A2 (es)
CA (1) CA2694058C (es)
CL (1) CL2008002398A1 (es)
CO (1) CO6260077A2 (es)
CR (1) CR11270A (es)
CY (1) CY1113486T1 (es)
DK (1) DK2188291T3 (es)
DO (1) DOP2010000058A (es)
EA (1) EA020996B1 (es)
EC (1) ECSP109964A (es)
ES (1) ES2396177T3 (es)
HK (1) HK1146273A1 (es)
HN (1) HN2010000313A (es)
HR (1) HRP20121022T1 (es)
IL (1) IL203163A (es)
MA (1) MA31608B1 (es)
MX (1) MX2010001746A (es)
MY (1) MY169738A (es)
NZ (1) NZ583267A (es)
PA (1) PA8793201A1 (es)
PE (1) PE20090944A1 (es)
PL (1) PL2188291T3 (es)
PT (1) PT2188291E (es)
RS (1) RS52559B (es)
SI (1) SI2188291T1 (es)
SV (1) SV2010003483A (es)
TN (1) TN2010000070A1 (es)
TW (1) TWI439272B (es)
UA (1) UA99735C2 (es)
UY (1) UY31293A1 (es)
WO (1) WO2009021992A2 (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA200902585B (en) * 2006-10-19 2010-09-29 Takeda Pharmaceutical Indole compound
CN101778851B (zh) 2007-08-14 2013-05-08 拜耳先灵医药股份有限公司 稠合的双环嘧啶
AU2009260447B2 (en) 2008-05-30 2012-03-29 Amgen Inc. Inhibitors of PI3 kinase
US20130310362A1 (en) * 2009-02-13 2013-11-21 Bayer Pharma Aktiegesellschaft Fused pyrimidines
US8957064B2 (en) * 2009-02-13 2015-02-17 Bayer Intellectual Property Gmbh Fused pyrimidines
WO2010114780A1 (en) 2009-04-01 2010-10-07 Merck Sharp & Dohme Corp. Inhibitors of akt activity
US20120071475A1 (en) 2009-04-27 2012-03-22 Shionogi & Co., Ltd. Urea derivatives having pi3k-inhibiting activity
JP2013530250A (ja) 2010-07-13 2013-07-25 バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング 二環式ピリミジン化合物
EP2598505B1 (en) 2010-07-28 2015-03-18 Bayer Intellectual Property GmbH Substituted imidazo[1,2-b]pyridazines
EP2694510B1 (en) 2011-04-07 2015-10-14 Bayer Intellectual Property GmbH Imidazopyridazines as akt kinase inhibitors
SG11201505631PA (en) 2013-01-23 2015-08-28 Astrazeneca Ab Chemical compounds
BR112015022206A2 (pt) * 2013-03-15 2017-07-18 Bayer Cropscience Lp composições, aditivos, e métodos para atenuar ou controlar a poeira da semente
US20140274685A1 (en) 2013-03-15 2014-09-18 Bayer Cropscience Lp Compositions, additives, and methods for mitigating or controlling seed dust
JP2020533376A (ja) 2017-09-15 2020-11-19 アドゥロ バイオテック，インク． ピラゾロピリミジノン化合物およびその使用

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SK18412002A3 (sk) 2000-06-30 2003-06-03 Wyeth Použitie substituovaných triazolopyrimidínových derivátov a farmaceutický prostriedok s ich obsahom
US7449488B2 (en) * 2002-06-04 2008-11-11 Schering Corporation Pyrazolopyrimidines as protein kinase inhibitors
CA2522431A1 (en) 2003-04-24 2004-11-11 Merck & Co., Inc. Inhibitors of akt activity
ATE499364T1 (de) * 2004-04-09 2011-03-15 Merck Sharp & Dohme Hemmer der akt aktivität
AR050188A1 (es) * 2004-08-03 2006-10-04 Uriach Y Compania S A J Compuestos heterociclicos condensados utiles en terapia como inhibidores de quinasas p38 y composiciones farmaceuticas que los contienen
JP2008510823A (ja) * 2004-08-23 2008-04-10 メルク エンド カムパニー インコーポレーテッド Ａｋｔ活性阻害剤
AU2005316826A1 (en) 2004-12-15 2006-06-22 Merck Sharp & Dohme Corp. Inhibitors of Akt activity
AU2005322085B2 (en) 2004-12-28 2012-07-19 Exelixis, Inc. [1H-pyrazolo[3, 4-d]pyrimidin-4-yl]-piperidine or -piperazine compounds as serine-threonine kinase modulators (p70S6K, Atk1 and Atk2) for the treatment of immunological, inflammatory and proliferative diseases
US7589068B2 (en) 2005-02-14 2009-09-15 Merck & Co., Inc. Inhibitors of Akt activity
BRPI0611717A2 (pt) 2005-06-10 2009-01-13 Merck & Co Inc composto, composiÇço farmacÊutica e uso do composto
CN101778851B (zh) 2007-08-14 2013-05-08 拜耳先灵医药股份有限公司 稠合的双环嘧啶
US8957064B2 (en) * 2009-02-13 2015-02-17 Bayer Intellectual Property Gmbh Fused pyrimidines

Also Published As

Publication number Publication date
US20090137607A1 (en) 2009-05-28
BRPI0815207A2 (pt) 2017-03-28
PT2188291E (pt) 2012-12-20
EA020996B1 (ru) 2015-03-31
DOP2010000058A (es) 2010-02-28
HN2010000313A (es) 2013-03-18
AU2008288392A1 (en) 2009-02-19
CN101778851B (zh) 2013-05-08
KR20100053556A (ko) 2010-05-20
EA201000298A1 (ru) 2010-10-29
SV2010003483A (es) 2010-07-06
TWI439272B (zh) 2014-06-01
EP2188291B1 (en) 2012-09-19
MA31608B1 (fr) 2010-08-02
CN101778851A (zh) 2010-07-14
UY31293A1 (es) 2009-03-31
CR11270A (es) 2010-05-19
JP5344637B2 (ja) 2013-11-20
ES2396177T3 (es) 2013-02-19
CL2008002398A1 (es) 2009-07-31
PE20090944A1 (es) 2009-08-09
CA2694058A1 (en) 2009-02-19
WO2009021992A2 (en) 2009-02-19
HRP20121022T1 (hr) 2013-01-31
MX2010001746A (es) 2010-03-10
US8614218B2 (en) 2013-12-24
IL203163A (en) 2015-01-29
DK2188291T3 (da) 2013-01-07
PL2188291T3 (pl) 2013-06-28
CY1113486T1 (el) 2016-06-22
NZ583267A (en) 2012-03-30
US7776864B2 (en) 2010-08-17
US20100184782A1 (en) 2010-07-22
WO2009021992A3 (en) 2009-04-16
AR067945A1 (es) 2009-10-28
CA2694058C (en) 2016-06-07
TN2010000070A1 (en) 2011-09-26
CO6260077A2 (es) 2011-03-22
JP2010535848A (ja) 2010-11-25
TW200922592A (en) 2009-06-01
EP2188291A2 (en) 2010-05-26
MY169738A (en) 2019-05-14
RS52559B (en) 2013-04-30
HK1146273A1 (en) 2011-05-20
PA8793201A1 (es) 2009-04-23
SI2188291T1 (sl) 2013-01-31
UA99735C2 (uk) 2012-09-25
AU2008288392B2 (en) 2013-10-24

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