HN2010000313A - Pirimidinas biciclicas fusionadas - Google Patents

Pirimidinas biciclicas fusionadas

Info

Publication number
HN2010000313A
HN2010000313A HN2010000313A HN2010000313A HN2010000313A HN 2010000313 A HN2010000313 A HN 2010000313A HN 2010000313 A HN2010000313 A HN 2010000313A HN 2010000313 A HN2010000313 A HN 2010000313A HN 2010000313 A HN2010000313 A HN 2010000313A
Authority
HN
Honduras
Prior art keywords
fusioned
pyrimidins
bicycle
fusionated
akt
Prior art date
Application number
HN2010000313A
Other languages
English (en)
Inventor
Holder Swen
Vennemann Mathias
Beneke Gerrit
Zulch Armin
Gekeler Volker
Beckers Thomas
Zimmermann Astrid
Joshi Hemant
Original Assignee
Bayer Schering Pharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP07118736A external-priority patent/EP2050748A1/en
Application filed by Bayer Schering Pharma Ag filed Critical Bayer Schering Pharma Ag
Publication of HN2010000313A publication Critical patent/HN2010000313A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

ESTA INVENCION SE REFIERE A COMPUESTOS DE FORMULA (I), LOS TAUTOMEROS O LOS ESTEREOISOMEROS DE ESTOS, O LAS SALES DE ESTOS, DONDE EL ANILLO B Y LA PIRIMIDINA A LA QUE ESTA FUSIONADO, R4, R5, R6 Y R7 TIENEN LOS VALORES INDICADOS EN LA DESCRIPCION Y LAS REIVINDICACIONES Y SON INHIBIDORES EFICACES DE LA VIA Pi3k/aKT.
HN2010000313A 2007-08-14 2010-02-12 Pirimidinas biciclicas fusionadas HN2010000313A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN1572MU2007 2007-08-14
EP07118736A EP2050748A1 (en) 2007-10-18 2007-10-18 Novel fused pyrimidines

Publications (1)

Publication Number Publication Date
HN2010000313A true HN2010000313A (es) 2013-03-18

Family

ID=40153211

Family Applications (1)

Application Number Title Priority Date Filing Date
HN2010000313A HN2010000313A (es) 2007-08-14 2010-02-12 Pirimidinas biciclicas fusionadas

Country Status (38)

Country Link
US (2) US7776864B2 (es)
EP (1) EP2188291B1 (es)
JP (1) JP5344637B2 (es)
KR (1) KR20100053556A (es)
CN (1) CN101778851B (es)
AR (1) AR067945A1 (es)
AU (1) AU2008288392B2 (es)
BR (1) BRPI0815207A2 (es)
CA (1) CA2694058C (es)
CL (1) CL2008002398A1 (es)
CO (1) CO6260077A2 (es)
CR (1) CR11270A (es)
CY (1) CY1113486T1 (es)
DK (1) DK2188291T3 (es)
DO (1) DOP2010000058A (es)
EA (1) EA020996B1 (es)
EC (1) ECSP109964A (es)
ES (1) ES2396177T3 (es)
HK (1) HK1146273A1 (es)
HN (1) HN2010000313A (es)
HR (1) HRP20121022T1 (es)
IL (1) IL203163A (es)
MA (1) MA31608B1 (es)
MX (1) MX2010001746A (es)
MY (1) MY169738A (es)
NZ (1) NZ583267A (es)
PA (1) PA8793201A1 (es)
PE (1) PE20090944A1 (es)
PL (1) PL2188291T3 (es)
PT (1) PT2188291E (es)
RS (1) RS52559B (es)
SI (1) SI2188291T1 (es)
SV (1) SV2010003483A (es)
TN (1) TN2010000070A1 (es)
TW (1) TWI439272B (es)
UA (1) UA99735C2 (es)
UY (1) UY31293A1 (es)
WO (1) WO2009021992A2 (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ576570A (en) * 2006-10-19 2010-11-26 Takeda Pharmaceutical 7-sulfonylamino-2-thiazol and 2-thiadiazol -indole compounds
PA8793201A1 (es) 2007-08-14 2009-04-23 Bayer Schering Pharma Ag Pirimidinas bicíclicas fusinadas
US8415376B2 (en) 2008-05-30 2013-04-09 Amgen Inc. Inhibitors of PI3 kinase
JP5777526B2 (ja) * 2009-02-13 2015-09-09 バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングＢａｙｅｒ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ ＧｍｂＨ 縮合ピリミジン類
EP2396331B1 (en) * 2009-02-13 2013-10-16 Bayer Intellectual Property GmbH Fused pyrimidines as akt inhibitors
WO2010114780A1 (en) 2009-04-01 2010-10-07 Merck Sharp & Dohme Corp. Inhibitors of akt activity
TW201103943A (en) 2009-04-27 2011-02-01 Shionogi & Co Urea derivative having pi3k inhibitory activity
US20130184273A1 (en) * 2010-07-13 2013-07-18 Bayer Intellectual Property Gmbh Bicyclic pyrimidines
CN103384670B (zh) 2010-07-28 2016-05-25 拜耳知识产权有限责任公司 取代的咪唑并[1,2-b]哒嗪
JO3068B1 (ar) 2011-04-07 2017-03-15 Bayer Ip Gmbh إيميدازوبيريميدينات كمثبطات كيناز akt
CN104936953B (zh) 2013-01-23 2017-03-08 阿斯利康(瑞典)有限公司 化合物
BR112015022206A2 (pt) * 2013-03-15 2017-07-18 Bayer Cropscience Lp composições, aditivos, e métodos para atenuar ou controlar a poeira da semente
US20140274685A1 (en) 2013-03-15 2014-09-18 Bayer Cropscience Lp Compositions, additives, and methods for mitigating or controlling seed dust
MA50256A (fr) 2017-09-15 2020-07-22 Aduro Biotech Inc Composés de pyrazolopyrimidinone et leurs utilisations

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SK18412002A3 (sk) 2000-06-30 2003-06-03 Wyeth Použitie substituovaných triazolopyrimidínových derivátov a farmaceutický prostriedok s ich obsahom
US7449488B2 (en) * 2002-06-04 2008-11-11 Schering Corporation Pyrazolopyrimidines as protein kinase inhibitors
WO2004096131A2 (en) 2003-04-24 2004-11-11 Merck & Co., Inc. Inhibitors of akt activity
DE602005026509D1 (de) 2004-04-09 2011-04-07 Merck Sharp & Dohme Hemmer der akt aktivität
AR050188A1 (es) * 2004-08-03 2006-10-04 Uriach Y Compania S A J Compuestos heterociclicos condensados utiles en terapia como inhibidores de quinasas p38 y composiciones farmaceuticas que los contienen
WO2006036395A2 (en) 2004-08-23 2006-04-06 Merck & Co., Inc. Inhibitors of akt activity
CA2589084A1 (en) 2004-12-15 2006-06-22 Merck & Co., Inc. Inhibitors of akt activity
WO2006071819A1 (en) * 2004-12-28 2006-07-06 Exelixis, Inc. [1h-pyrazolo[3, 4-d]pyrimidin-4-yl]-piperidine or -piperazine compounds as serine-theoronine kinase modulators (p70s6k, atk1 and atk2) for the treatment of immunological, inflammatory and proliferative diseases
CN101115479A (zh) 2005-02-14 2008-01-30 默克公司 Akt活性抑制剂
NZ563423A (en) 2005-06-10 2010-05-28 Merck Sharp & Dohme Inhibitors of AKT activity
PA8793201A1 (es) 2007-08-14 2009-04-23 Bayer Schering Pharma Ag Pirimidinas bicíclicas fusinadas
JP5777526B2 (ja) * 2009-02-13 2015-09-09 バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングＢａｙｅｒ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ ＧｍｂＨ 縮合ピリミジン類

Also Published As

Publication number Publication date
UY31293A1 (es) 2009-03-31
CO6260077A2 (es) 2011-03-22
HRP20121022T1 (hr) 2013-01-31
DK2188291T3 (da) 2013-01-07
TWI439272B (zh) 2014-06-01
CA2694058C (en) 2016-06-07
WO2009021992A3 (en) 2009-04-16
EP2188291A2 (en) 2010-05-26
HK1146273A1 (en) 2011-05-20
CY1113486T1 (el) 2016-06-22
WO2009021992A2 (en) 2009-02-19
AU2008288392B2 (en) 2013-10-24
AR067945A1 (es) 2009-10-28
ECSP109964A (es) 2010-03-31
CL2008002398A1 (es) 2009-07-31
EA020996B1 (ru) 2015-03-31
CA2694058A1 (en) 2009-02-19
PL2188291T3 (pl) 2013-06-28
US20100184782A1 (en) 2010-07-22
US7776864B2 (en) 2010-08-17
MY169738A (en) 2019-05-14
RS52559B (en) 2013-04-30
US20090137607A1 (en) 2009-05-28
MX2010001746A (es) 2010-03-10
PT2188291E (pt) 2012-12-20
KR20100053556A (ko) 2010-05-20
JP5344637B2 (ja) 2013-11-20
SV2010003483A (es) 2010-07-06
EA201000298A1 (ru) 2010-10-29
IL203163A (en) 2015-01-29
BRPI0815207A2 (pt) 2017-03-28
ES2396177T3 (es) 2013-02-19
US8614218B2 (en) 2013-12-24
TW200922592A (en) 2009-06-01
AU2008288392A1 (en) 2009-02-19
JP2010535848A (ja) 2010-11-25
SI2188291T1 (sl) 2013-01-31
CN101778851A (zh) 2010-07-14
PE20090944A1 (es) 2009-08-09
CN101778851B (zh) 2013-05-08
NZ583267A (en) 2012-03-30
PA8793201A1 (es) 2009-04-23
UA99735C2 (uk) 2012-09-25
MA31608B1 (fr) 2010-08-02
EP2188291B1 (en) 2012-09-19
DOP2010000058A (es) 2010-02-28
TN2010000070A1 (en) 2011-09-26
CR11270A (es) 2010-05-19

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