GT200800211A - Derivados de dihidropirazolopirimidinona - Google Patents

Derivados de dihidropirazolopirimidinona

Info

Publication number
GT200800211A
GT200800211A GT200800211A GT200800211A GT200800211A GT 200800211 A GT200800211 A GT 200800211A GT 200800211 A GT200800211 A GT 200800211A GT 200800211 A GT200800211 A GT 200800211A GT 200800211 A GT200800211 A GT 200800211A
Authority
GT
Guatemala
Prior art keywords
group
compounds
dihydropirazolopirimidinone
derivatives
renting
Prior art date
Application number
GT200800211A
Other languages
English (en)
Inventor
Sakamoto Toshihiro
Sunami Satoshi
Yamamoto Fuyuki
Niiyama Kenji
Bamba Makoto
Takahashi Keiji
Furuyama Hidetomo
Sagara Takeshi
Otsuki Sachie
Nishibata Toshihide
Yoshizumi Takashi
Hirai Hiroshi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38655640&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=GT200800211(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed filed Critical
Publication of GT200800211A publication Critical patent/GT200800211A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4162—1,2-Diazoles condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

LA INVENCIÓN SE REFIERE A COMPUESTOS DE FÓRMULA GENERAL (I) EN LA QUE A1 SE SELECCIONA DE LA FÓRMULA (AA1), R1 ES UN GRUPO ALQUENILO INFERIOR O UN GRUPO ALQUINILO INFERIOR, R2 ES UN GRUPO FENILO, PIRIDILO O TIENILO, R5 Y R6 SON UN ÁTOMO DE HIDRÓGENO, UN GRUPO ALQUILO INFERIOR O UN GRUPO HIDROXIALQUILO INFERIOR, ETC. LOS COMPUESTOS DE LA INVENCIÓN TIENEN EXCELENTE EFECTO INHIBIDOR DE QUINASA WEEL Y SON POR LO TANTO, ÚTILES EN EL CAMPO DE LAS MEDICINAS, ESPECIALMENTE EN EL TRATAMIENTO DE DIVERSOS CÁNCERES.
GT200800211A 2006-04-27 2008-10-10 Derivados de dihidropirazolopirimidinona GT200800211A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2006124208 2006-04-27

Publications (1)

Publication Number Publication Date
GT200800211A true GT200800211A (es) 2009-04-07

Family

ID=38655640

Family Applications (1)

Application Number Title Priority Date Filing Date
GT200800211A GT200800211A (es) 2006-04-27 2008-10-10 Derivados de dihidropirazolopirimidinona

Country Status (39)

Country Link
US (4) US7935708B2 (es)
EP (2) EP2017278B1 (es)
JP (2) JP4513919B2 (es)
KR (1) KR101409161B1 (es)
CN (1) CN101432284B (es)
AR (1) AR060635A1 (es)
AT (1) ATE475662T1 (es)
AU (1) AU2007244185B2 (es)
BR (1) BRPI0710081A2 (es)
CA (1) CA2650119C (es)
CR (1) CR10359A (es)
CY (2) CY1111069T1 (es)
DE (1) DE602007008085D1 (es)
DK (2) DK2016080T3 (es)
DO (1) DOP2007000084A (es)
EC (1) ECSP088812A (es)
ES (2) ES2348751T3 (es)
GT (1) GT200800211A (es)
HK (1) HK1132498A1 (es)
HN (1) HN2008001532A (es)
HR (2) HRP20100563T1 (es)
HU (1) HUE032987T2 (es)
IL (1) IL194367A (es)
LT (1) LT2017278T (es)
MA (1) MA30428B1 (es)
MX (1) MX2008013063A (es)
MY (1) MY145408A (es)
NO (1) NO341617B1 (es)
NZ (1) NZ571196A (es)
PE (1) PE20080695A1 (es)
PL (2) PL2017278T3 (es)
PT (2) PT2017278T (es)
RU (1) RU2437885C2 (es)
SI (2) SI2017278T1 (es)
SV (1) SV2009003060A (es)
TW (1) TWI409262B (es)
UA (1) UA96152C2 (es)
WO (2) WO2007126122A1 (es)
ZA (1) ZA200807748B (es)

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CN113880844B (zh) * 2021-09-29 2023-02-14 武汉九州钰民医药科技有限公司 Wee1蛋白激酶抑制剂adavosertib的化学合成方法
CN113735863A (zh) * 2021-09-29 2021-12-03 武汉九州钰民医药科技有限公司 Wee1抑制剂adavosertib的制备工艺
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