NO20084968L - Dihydropyrazolpyrimidinonderivater - Google Patents
DihydropyrazolpyrimidinonderivaterInfo
- Publication number
- NO20084968L NO20084968L NO20084968A NO20084968A NO20084968L NO 20084968 L NO20084968 L NO 20084968L NO 20084968 A NO20084968 A NO 20084968A NO 20084968 A NO20084968 A NO 20084968A NO 20084968 L NO20084968 L NO 20084968L
- Authority
- NO
- Norway
- Prior art keywords
- group
- alkyl group
- aal
- pyridyl
- cancer
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/4162—1,2-Diazoles condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
hvor A1 er valgt fra den følgende formel (aal): (aa1), Ri er en lavere alkenylgruppe eller en lavere alkynylgruppe, R2 er en fenyl-, pyridyl- eller tienyl-gruppe, og R5 og R6 er et hydrogenatom, en lavere alkylgruppe eller en hydroksy-lavere-alkylgruppe, osv. Forbindelsene oppviser utmerket Weel-kinase-inhiberende virkning og er derfor anvendelige innenfor det medisinske området, spesielt for behandling av forskjellige typer kreft.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2006124208 | 2006-04-27 | ||
PCT/JP2007/059408 WO2007126122A1 (en) | 2006-04-27 | 2007-04-25 | Dihydropyrazolopyrimidinone derivatives |
Publications (2)
Publication Number | Publication Date |
---|---|
NO20084968L true NO20084968L (no) | 2008-11-26 |
NO341617B1 NO341617B1 (no) | 2017-12-11 |
Family
ID=38655640
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20084968A NO341617B1 (no) | 2006-04-27 | 2008-11-26 | Dihydropyrazolpyrimidinonderivater, deres anvendelse i terapi og til behandling av kreft, deres anvendelse for fremstilling av et medikament, og for anvendelse som strålingssensibilisator, farmasøytisk sammensetning derav, samt et kombinert preparat for administrering ved behandling av kreft. |
Country Status (39)
Country | Link |
---|---|
US (4) | US7834019B2 (no) |
EP (2) | EP2017278B1 (no) |
JP (2) | JP4513919B2 (no) |
KR (1) | KR101409161B1 (no) |
CN (1) | CN101432284B (no) |
AR (1) | AR060635A1 (no) |
AT (1) | ATE475662T1 (no) |
AU (1) | AU2007244185B2 (no) |
BR (1) | BRPI0710081A2 (no) |
CA (1) | CA2650119C (no) |
CR (1) | CR10359A (no) |
CY (2) | CY1111069T1 (no) |
DE (1) | DE602007008085D1 (no) |
DK (2) | DK2016080T3 (no) |
DO (1) | DOP2007000084A (no) |
EC (1) | ECSP088812A (no) |
ES (2) | ES2348751T3 (no) |
GT (1) | GT200800211A (no) |
HK (1) | HK1132498A1 (no) |
HN (1) | HN2008001532A (no) |
HR (2) | HRP20100563T1 (no) |
HU (1) | HUE032987T2 (no) |
IL (1) | IL194367A (no) |
LT (1) | LT2017278T (no) |
MA (1) | MA30428B1 (no) |
MX (1) | MX2008013063A (no) |
MY (1) | MY145408A (no) |
NO (1) | NO341617B1 (no) |
NZ (1) | NZ571196A (no) |
PE (1) | PE20080695A1 (no) |
PL (2) | PL2016080T3 (no) |
PT (2) | PT2017278T (no) |
RU (1) | RU2437885C2 (no) |
SI (2) | SI2016080T1 (no) |
SV (1) | SV2009003060A (no) |
TW (1) | TWI409262B (no) |
UA (1) | UA96152C2 (no) |
WO (2) | WO2007126128A1 (no) |
ZA (1) | ZA200807748B (no) |
Families Citing this family (74)
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PE20080695A1 (es) | 2006-04-27 | 2008-06-28 | Banyu Pharma Co Ltd | Derivados de dihidropirazolopirimidinona como inhibidores de quinasa weel |
EP2155752B1 (en) | 2007-04-25 | 2018-09-19 | Merck Sharp & Dohme Corp. | Polymorph of dihydropyrazolopyrimidinone derivative as weel kinase.inhibitor |
WO2008141385A1 (en) * | 2007-05-21 | 2008-11-27 | Biota Scientific Management Pty Ltd | Viral polymerase inhibitors |
US8329711B2 (en) * | 2007-10-23 | 2012-12-11 | Msd K.K. | Pyridone-substituted-dihydropyrazolopyrimidinone derivative |
US8507504B2 (en) | 2008-06-12 | 2013-08-13 | Merck Sharp & Dohme Corp. | Process for producing bicycloaniline derivatives |
AU2009325400A1 (en) * | 2008-12-12 | 2010-06-17 | Msd K.K. | Dihydropyrimidopyrimidine derivatives |
WO2010076887A1 (en) * | 2009-01-05 | 2010-07-08 | Banyu Pharmaceutical Co.,Ltd. | Predictive biomarkers useful for cancer therapy mediated by a wee1 inhibitor |
US8288396B2 (en) | 2009-02-25 | 2012-10-16 | Msdkk | Pyrimidopyrimidoindazole derivative |
EP2473633A4 (en) * | 2009-09-02 | 2013-03-06 | Msd Kk | USE OF ONE OR MORE BIOMARKERS TO IDENTIFY A WEE1 DISEASED PATIENT AND PROCEDURE FOR TREATING CANCER MEDIATED BY DYSFUNCTIONAL OR ABERRANT P53 BY ADMINISTERING A WEE1 HEMMER |
EP2477628B1 (en) | 2009-09-15 | 2014-08-20 | Merck Sharp & Dohme Corp. | Preparation of crystalline hemihydrate forms of dihydropyrazolopyrimidinone |
KR101884960B1 (ko) | 2010-11-16 | 2018-08-30 | 어레이 바이오파마 인크. | 체크포인트 키나제 1 억제제 및 wee 1 키나제 억제제의 조합 |
CN106278943B (zh) * | 2011-04-27 | 2019-07-30 | 日本瑞翁株式会社 | 光学薄膜、聚合性化合物、聚合性组合物、高分子、光学各向异性体以及肼化合物 |
WO2013013031A1 (en) * | 2011-07-19 | 2013-01-24 | Abbvie Inc. | Pyridazino [4, 5 -d] pyrimidin- (6h) -one inhibitors of wee - 1 kinase |
EP2755482B1 (en) | 2011-09-15 | 2016-06-01 | Merck Sharp & Dohme Corp. | Combination of mk-1775 and mk-8776 for treating cancer |
EP2776434A1 (en) | 2011-10-20 | 2014-09-17 | Abbvie Inc. | Pyridopyrimidinone inhibitors of kinases |
US9718821B2 (en) * | 2012-02-23 | 2017-08-01 | Abbvie Inc. | Pyridopyrimidinone inhibitors of kinases |
WO2014062454A1 (en) * | 2012-10-15 | 2014-04-24 | Merck Sharp & Dohme Corp. | Compositions and methods for treating cancer |
RU2660349C2 (ru) | 2012-11-28 | 2018-07-05 | Мерк Шарп И Доум Корп. | Композиции и способы для лечения злокачественной опухоли |
MX2015014249A (es) | 2013-04-09 | 2016-06-02 | Lixte Biotechnology Inc | Formulaciones de oxabicicloheptanos y oxabicicloheptenos. |
GB201306610D0 (en) * | 2013-04-11 | 2013-05-29 | Almac Discovery Ltd | Pharmaceutical compounds |
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KR20170045751A (ko) * | 2014-12-17 | 2017-04-27 | 데루타-후라이 화마 가부시키가이샤 | 고령이나 말기의 암환자를 치료 또는 경감하기 위한 의약 조성물 |
EP3286195A1 (en) | 2015-04-17 | 2018-02-28 | AbbVie Inc. | Indazolones as modulators of tnf signaling |
WO2016168633A1 (en) | 2015-04-17 | 2016-10-20 | Abbvie Inc. | Indazolones as modulators of tnf signaling |
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PL3345907T3 (pl) * | 2015-09-01 | 2020-09-07 | Taiho Pharmaceutical Co., Ltd. | Związki pirazolo[3,4-d]pirymidynowe lub ich sole |
CN105130986B (zh) * | 2015-09-30 | 2017-07-18 | 广州科擎新药开发有限公司 | 嘧啶或吡啶并吡啶酮类化合物及其应用 |
WO2017075629A2 (en) * | 2015-11-01 | 2017-05-04 | The Regents Of The University Of Colorado, A Body Corporate | Wee 1 kinase inhibitors and methods of making and using the same |
CN106271589B (zh) * | 2016-06-23 | 2018-12-28 | 中山市美捷时包装制品有限公司 | 一种用于预装阀杆、弹簧、垫片的组装设备 |
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CN106719769A (zh) * | 2016-11-28 | 2017-05-31 | 山东农业大学 | 一种含香菇多糖、苯醚甲环唑和噻虫啉的病虫兼治农药组合物 |
WO2018133829A1 (zh) * | 2017-01-23 | 2018-07-26 | 南京明德新药研发股份有限公司 | 作为Wee1抑制剂的1,2-二氢-3H-吡唑[3,4-d]嘧啶-3-酮衍生物 |
GB201703881D0 (en) * | 2017-03-10 | 2017-04-26 | Almac Discovery Ltd | Pharmaceutical compounds |
JP7140337B2 (ja) * | 2017-03-23 | 2022-09-21 | シャンハイ ドーァ ノボ ファーマテック カンパニー,リミティド | ピラゾロ[3,4-d]ピリミジン-3-オンの大環状誘導体、その医薬組成物及び応用 |
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CN108653282B (zh) * | 2018-06-28 | 2020-08-14 | 中国科学院昆明植物研究所 | 苯并噻唑类及苯并吡咯类化合物在制备抗肿瘤药物中的应用 |
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