ATE186461T1 - Verfahren zur herstellung wasserlöslicher camptothecinanaloge, sowie die verbindungen 10- hydroxy-11-c(1-6)-alkoxycamptothecin - Google Patents

Verfahren zur herstellung wasserlöslicher camptothecinanaloge, sowie die verbindungen 10- hydroxy-11-c(1-6)-alkoxycamptothecin

Info

Publication number
ATE186461T1
ATE186461T1 AT91918278T AT91918278T ATE186461T1 AT E186461 T1 ATE186461 T1 AT E186461T1 AT 91918278 T AT91918278 T AT 91918278T AT 91918278 T AT91918278 T AT 91918278T AT E186461 T1 ATE186461 T1 AT E186461T1
Authority
AT
Austria
Prior art keywords
analogs
compounds
alkoxycamptothecine
camptothecine
hydroxy
Prior art date
Application number
AT91918278T
Other languages
English (en)
Inventor
Joseph Marian Fortunak
Jeffery Lee Wood
Antonietta Rose Mastrocola
Mark Mellinger
Patrick Lee Burk
Original Assignee
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp
Application granted granted Critical
Publication of ATE186461T1 publication Critical patent/ATE186461T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
AT91918278T 1990-09-28 1991-09-23 Verfahren zur herstellung wasserlöslicher camptothecinanaloge, sowie die verbindungen 10- hydroxy-11-c(1-6)-alkoxycamptothecin ATE186461T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US58964390A 1990-09-28 1990-09-28

Publications (1)

Publication Number Publication Date
ATE186461T1 true ATE186461T1 (de) 1999-11-15

Family

ID=24358879

Family Applications (1)

Application Number Title Priority Date Filing Date
AT91918278T ATE186461T1 (de) 1990-09-28 1991-09-23 Verfahren zur herstellung wasserlöslicher camptothecinanaloge, sowie die verbindungen 10- hydroxy-11-c(1-6)-alkoxycamptothecin

Country Status (25)

Country Link
US (1) US5734056A (de)
EP (1) EP0547165B1 (de)
JP (1) JP2848958B2 (de)
CN (1) CN1033509C (de)
AT (1) ATE186461T1 (de)
AU (1) AU664830B2 (de)
CA (1) CA2090967C (de)
CZ (1) CZ51593A3 (de)
DE (1) DE69131775T2 (de)
DK (1) DK0547165T3 (de)
ES (1) ES2137932T3 (de)
FI (1) FI931384A (de)
GR (1) GR3031823T3 (de)
HK (1) HK1012283A1 (de)
HU (1) HUT70024A (de)
IE (1) IE913402A1 (de)
IL (1) IL99571A (de)
NO (1) NO931153D0 (de)
NZ (1) NZ239947A (de)
PT (1) PT99109B (de)
SI (1) SI9111599A (de)
SK (1) SK283693B6 (de)
WO (1) WO1992005785A1 (de)
YU (1) YU159991A (de)
ZA (1) ZA917748B (de)

Families Citing this family (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AP9300587A0 (en) * 1992-11-12 1995-05-05 Glaxo Inc Water soluble camptothecin derivatives.
US5527913A (en) * 1993-02-25 1996-06-18 The Stehlin Foundation For Cancer Research Methods for purifying camptothecin compounds
US5880131A (en) * 1993-10-20 1999-03-09 Enzon, Inc. High molecular weight polymer-based prodrugs
US5447936A (en) * 1993-12-22 1995-09-05 Bionumerik Pharmaceuticals, Inc. Lactone stable formulation of 10-hydroxy 7-ethyl camptothecin and methods for uses thereof
GB9402934D0 (en) * 1994-02-16 1994-04-06 Erba Carlo Spa Camptothecin derivatives and process for their preparation
KR960029336A (ko) 1995-01-09 1996-08-17 김충환 캄토테신 유도체, 그의 제조 방법 및 이를 함유하는 항암제
US5726181A (en) * 1995-06-05 1998-03-10 Bionumerik Pharmaceuticals, Inc. Formulations and compositions of poorly water soluble camptothecin derivatives
JPH08333370A (ja) * 1995-06-08 1996-12-17 Kyorin Pharmaceut Co Ltd 水に可溶な新規フルオロエチルカンプトテシン誘導体、及びその製造方法
WO1997019085A1 (en) * 1995-11-22 1997-05-29 Research Triangle Institute Camptothecin compounds with combined topoisomerase i inhibition and dna alkylation properties
US5731316A (en) 1996-01-30 1998-03-24 The Stehlin Foundation For Cancer Research Derivatives of camptothecin and methods of treating cancer using these derivatives
US6407118B1 (en) 1996-01-30 2002-06-18 The Stehlin Foundation For Cancer Research Derivatives of camptothecin and methods of treating cancer using these derivatives
GB9601779D0 (en) * 1996-01-30 1996-04-03 Pharmacia Spa 9, 10 Disubstituted camptothecin derivatives
US6096336A (en) * 1996-01-30 2000-08-01 The Stehlin Foundation For Cancer Research Liposomal prodrugs comprising derivatives of camptothecin and methods of treating cancer using these prodrugs
US6043367A (en) * 1998-09-30 2000-03-28 Roffler; Steve Proactive antitumor compounds
US6352996B1 (en) 1999-08-03 2002-03-05 The Stehlin Foundation For Cancer Research Liposomal prodrugs comprising derivatives of camptothecin and methods of treating cancer using these prodrugs
US6228855B1 (en) 1999-08-03 2001-05-08 The Stehlin Foundation For Cancer Research Aromatic esters of camptothecins and methods to treat cancers
EP2266607A3 (de) 1999-10-01 2011-04-20 Immunogen, Inc. Immunokonjugate für Krebsbehandlung
WO2004055020A1 (en) * 2002-12-16 2004-07-01 Council Of Scientific And Industrial Research Process for the direct preparation of 5-alkoxy and 5-acyloxy analogues of campthothecins or mappicene ketones
AU2003223109A1 (en) * 2003-03-31 2004-10-25 Council Of Scientific And Industrial Research Process for preparing topotecan from 10-hydroxy-4-(s) camptothecin
CN100344633C (zh) * 2003-05-12 2007-10-24 台湾神隆股份有限公司 用于制备7－烷基－10－羟基－20(s)－喜树碱的方法
CZ298934B6 (cs) * 2003-08-26 2008-03-12 Pliva- Lachema A.S. Zpusob výroby 7-ethyl-10-hydroxykamptothecinu
CZ299329B6 (cs) * 2003-08-26 2008-06-18 Pliva-Lachema A.S. Zpusob výroby 7-ethyl-10-[ 4-(1-piperidino)-1-piperidino]karbonyloxykamptothecinu
TWI333492B (en) * 2003-11-12 2010-11-21 Smithkline Beecham Cork Ltd Crystalline topotecan hydrochloride product and preparation thereof
CZ299593B6 (cs) * 2003-12-16 2008-09-10 Pliva-Lachema A. S. Zpusob výroby 7-ethyl-10-hydroxykamptothecinu
US20050267141A1 (en) 2004-05-28 2005-12-01 Phytogen Life Sciences Inc. Process to prepare camptothecin derivatives
US20050272757A1 (en) * 2004-06-04 2005-12-08 Phytogen Life Sciences Inc. Process to prepare camptothecin derivatives and novel intermediate and compounds thereof
US20080182990A1 (en) * 2004-08-09 2008-07-31 Shilpa Medicare Limited Process for the Preparation of Irinotecan Hydrochloride Trihydrate
NZ554677A (en) * 2004-11-05 2010-08-27 Samyang Corp Pharmaceutical formulation for increasing solubility of 10-hydroxycamptothecin compounds in non-aqueous polar solvents
US20060135546A1 (en) * 2004-12-16 2006-06-22 Jagadevappa Basavaraja Methods for the purification of 20(S)- camptothecin
JP5177429B2 (ja) * 2005-07-18 2013-04-03 バイパー サイエンシズ，インコーポレイティド 癌の治療
EP1943253A1 (de) * 2005-10-10 2008-07-16 Cipla Limited Neue kristalline formen
US7547785B2 (en) 2005-12-26 2009-06-16 Dr. Reddy's Laboratories Limited Process for preparing topotecan
WO2007127839A2 (en) * 2006-04-26 2007-11-08 The Regents Of The University Of California Compositions and methods for convection enhanced delivery of high molecular weight neurotherapeutics
PE20080695A1 (es) 2006-04-27 2008-06-28 Banyu Pharma Co Ltd Derivados de dihidropirazolopirimidinona como inhibidores de quinasa weel
US20100279327A1 (en) * 2006-06-12 2010-11-04 Bipar Sciences, Inc. Method of treating diseases with parp inhibitors
JP2010504079A (ja) * 2006-06-12 2010-02-12 バイパー サイエンシズ，インコーポレイティド Ｐａｒｐ阻害剤を用いる疾病の治療方法
US20080039485A1 (en) * 2006-08-08 2008-02-14 Targetgen Biotechnology Co., Ltd. Low-dose-long-term pharmaceutical composition comprising camptothecin derivatives for the treatment of cancers
JP2008081492A (ja) 2006-08-31 2008-04-10 Banyu Pharmaceut Co Ltd オーロラａ選択的阻害作用を有する新規アミノピリジン誘導体
US7994222B2 (en) * 2006-09-05 2011-08-09 Bipar Sciences, Inc. Monitoring of the inhibition of fatty acid synthesis by iodo-nitrobenzamide compounds
CN101522609A (zh) * 2006-09-05 2009-09-02 彼帕科学公司 癌症的治疗
US7977336B2 (en) 2006-12-28 2011-07-12 Banyu Pharmaceutical Co. Ltd Aminopyrimidine derivatives as PLK1 inhibitors
US7977483B2 (en) 2007-04-11 2011-07-12 Scinopharm Taiwan, Ltd. Process for making topotecan
EP2211854A4 (de) * 2007-10-19 2011-01-12 Bipar Sciences Inc Verfahren und zusammensetzungen zur behandlung von krebs mit parp-inhibitoren vom benzopyrontyp
JPWO2009054332A1 (ja) 2007-10-23 2011-03-03 萬有製薬株式会社 ピリドン置換ジヒドロピラゾロピリミジノン誘導体
US7732491B2 (en) * 2007-11-12 2010-06-08 Bipar Sciences, Inc. Treatment of breast cancer with a PARP inhibitor alone or in combination with anti-tumor agents
CA2705417A1 (en) * 2007-11-12 2009-05-22 Bipar Sciences, Inc. Treatment of uterine cancer and ovarian cancer with a parp inhibitor alone or in combination with anti-tumor agents
ITMI20072268A1 (it) 2007-12-04 2009-06-05 Antibioticos Spa Polimorfi cristallini di topotecan cloridrato con elevato grado di purezza e metodi per la loro preparazione
CN101450949B (zh) * 2007-12-07 2011-10-05 上海龙翔生物医药开发有限公司 一种10-羟基喜树碱的化学半合成工艺
CN101888777A (zh) * 2007-12-07 2010-11-17 彼帕科学公司 用拓扑异构酶抑制剂和parp抑制剂的组合治疗癌症
AU2009252303B2 (en) 2008-05-29 2013-04-04 Microbiopharm Japan Co., Ltd. Production method for camptothecin derivative
AU2010218781A1 (en) 2009-02-25 2011-07-28 Msd K.K. Pyrimidopyrimidoindazole derivative
US8481503B2 (en) 2009-03-06 2013-07-09 Merck Sharp & Dohme Corp. Combination cancer therapy with an AKT inhibitor and other anticancer agents
JP6013359B2 (ja) 2010-12-17 2016-10-25 ノバルティス アーゲー 組合せ
US20130303560A1 (en) 2011-02-01 2013-11-14 Sunnybrook Research Institute Combination
CN103145720B (zh) * 2013-02-20 2015-09-30 上海北卡医药技术有限公司 一种10-羟基喜树碱的一水合物的制备方法
EP2881396A1 (de) * 2013-12-03 2015-06-10 Synbias Pharma AG Verfahren zur Synthese von Irinotecan
WO2023220641A2 (en) 2022-05-11 2023-11-16 Juno Therapeutics, Inc. Methods and uses related to t cell therapy and production of same

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4473692A (en) * 1981-09-04 1984-09-25 Kabushiki Kaisha Yakult Honsha Camptothecin derivatives and process for preparing same
JPS595188A (ja) * 1982-06-30 1984-01-12 Yakult Honsha Co Ltd １０−ヒドロキシカンプトテシンの製造法
JPS5946284A (ja) * 1982-09-10 1984-03-15 Yakult Honsha Co Ltd １１−ニトロカンプトテシン誘導体およびその製造法
US4981968A (en) * 1987-03-31 1991-01-01 Research Triangle Institute Synthesis of camptothecin and analogs thereof
US4894456A (en) * 1987-03-31 1990-01-16 Research Triangle Institute Synthesis of camptothecin and analogs thereof
US4943579A (en) * 1987-10-06 1990-07-24 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Water soluble prodrugs of camptothecin
US5004758A (en) * 1987-12-01 1991-04-02 Smithkline Beecham Corporation Water soluble camptothecin analogs useful for inhibiting the growth of animal tumor cells
JPH0615547B2 (ja) * 1988-01-20 1994-03-02 株式会社ヤクルト本社 新規なカンプトテシン誘導体
GB9008605D0 (en) * 1990-04-17 1990-06-13 Smith Kline French Lab Process
HU213136B (en) * 1990-08-14 1997-02-28 Kyorin Seiyaku Kk Process for producing fluoroethyl camptothecin derivatives and pharmaceutical compositions containing them
US5352789A (en) * 1993-02-25 1994-10-04 The Stehlin Foundation For Cancer Research Methods for purifying camptothecin compounds

Also Published As

Publication number Publication date
PT99109A (pt) 1992-08-31
DE69131775T2 (de) 2000-04-20
ZA917748B (en) 1992-09-30
HK1012283A1 (en) 1999-07-30
AU8739991A (en) 1992-04-28
DE69131775D1 (de) 1999-12-16
JP2848958B2 (ja) 1999-01-20
NO931153L (no) 1993-03-26
FI931384A0 (fi) 1993-03-26
CA2090967A1 (en) 1992-03-29
IL99571A0 (en) 1992-08-18
US5734056A (en) 1998-03-31
HUT70024A (en) 1995-09-28
DK0547165T3 (da) 2000-03-27
EP0547165B1 (de) 1999-11-10
WO1992005785A1 (en) 1992-04-16
SK283693B6 (sk) 2003-12-02
AU664830B2 (en) 1995-12-07
SK25993A3 (en) 1993-07-07
ES2137932T3 (es) 2000-01-01
EP0547165A1 (de) 1993-06-23
GR3031823T3 (en) 2000-02-29
PT99109B (pt) 1999-02-26
IE913402A1 (en) 1992-04-08
IL99571A (en) 2000-08-31
JPH06501476A (ja) 1994-02-17
CZ51593A3 (en) 1994-01-19
HU9300878D0 (en) 1993-06-28
YU159991A (sh) 1994-06-10
NZ239947A (en) 1994-07-26
CN1033509C (zh) 1996-12-11
CA2090967C (en) 2007-02-06
EP0547165A4 (de) 1994-03-30
NO931153D0 (no) 1993-03-26
FI931384A (fi) 1993-03-26
SI9111599A (sl) 1998-02-28
CN1062731A (zh) 1992-07-15

Similar Documents

Publication Publication Date Title
ATE186461T1 (de) Verfahren zur herstellung wasserlöslicher camptothecinanaloge, sowie die verbindungen 10- hydroxy-11-c(1-6)-alkoxycamptothecin
ATE306252T1 (de) Verfahren zur herstellung kristalliner partikel zur inhalation
DE60316688D1 (de) Dehydrophenylahistine und analoge davon sowie ein verfahren zur herstellung von dehydrophenylahistinen und analogen davon
ATE213249T1 (de) Verfahren zur herstellung von n- phosphonomethyliminodiessigesäure.
ATA81581A (de) Verfahren zur herstellung eines mischsinterkoerpers aus siliziumnitrid/bornitrid
AT375378B (de) Verfahren zur herstellung von 4'-deoxydaunorubicin
DE69027221D1 (de) Substituierte 4-phenyl-4-piperidincarboxamide mit sowohl lokalanästhetischer als auch schmerzlindernder wirkung sowie verfahren zur herstellung
AT373225B (de) Verfahren zur herstellung wasserunloeslicher, ge- bundenes wasser und gebundene tenside enthaltender roentgenamorpher alkalialumosilikate
JPS52286A (en) Method of preparing 1-(3-phenylpropyl)-4-acylpiperazine derivatives
DE60015563D1 (de) Verfahren zur herstellung von benzoperhydroisoindolen
DE3672526D1 (de) Verfahren zur herstellung eines halbleiterbauelementes mittels ionenimplantation.
EP0173950A3 (de) Neuer alpha-Glukosidase Inhibitor, Verfahren zur seiner Herstellung, seine Verwendung und pharmazeutische Präparate
DE69012279T2 (de) Verfahren zur Herstellung ungesättigter Verbindungen.
ATE207139T1 (de) Verfahren zur herstellung von butantetracarbonsäure
DE69729631D1 (de) Verfahren zur herstellung von granisetron
ATA333379A (de) Verfahren zur herstellung neuer derivate des(1, 3)-benzodioxins
DE68907900T2 (de) Verfahren zur herstellung von oxyessigsäure/hydroxyethyletherverbindung.
EP0154937A3 (de) 6-(3-Thienylmethylamino)-purin, Verfahren zu seiner Herstellung und seine Verwendung
ATE230743T1 (de) Verfahren zur herstellung von lysergsäure
AT363932B (de) Verfahren zur herstellung von neuen salzen von 2,8-dicarboxy-4,6-dioxo-10-propyl-4h,6h-benzo (1,2-b:5,4-b')dipyran
HUT45952A (en) Process for producing soil meliorizator
ATA129585A (de) Verfahren zur herstellung des basischen thioaethers 2-((2-amino-aethyl)-thiomethyl)-5(dimethyl-aminomethyl)-furan sowie der saeureadditionssalze desselben
JPS5247989A (en) Microbial production of alpha-ketoglutaric acid

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
EELA Cancelled due to lapse of time