BR112021026618A2 - Composto de pirazolpirimidina, método de preparação do mesmo e aplicações do mesmo - Google Patents
Composto de pirazolpirimidina, método de preparação do mesmo e aplicações do mesmoInfo
- Publication number
- BR112021026618A2 BR112021026618A2 BR112021026618A BR112021026618A BR112021026618A2 BR 112021026618 A2 BR112021026618 A2 BR 112021026618A2 BR 112021026618 A BR112021026618 A BR 112021026618A BR 112021026618 A BR112021026618 A BR 112021026618A BR 112021026618 A2 BR112021026618 A2 BR 112021026618A2
- Authority
- BR
- Brazil
- Prior art keywords
- compound
- pyrazolpyrimidine
- applications
- preparation
- represented
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/43—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
- C07C211/44—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having amino groups bound to only one six-membered aromatic ring
- C07C211/49—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having amino groups bound to only one six-membered aromatic ring having at least two amino groups bound to the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/46—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/73—Unsubstituted amino or imino radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Abstract
composto de pirazolpirimidina, método de preparação do mesmo e aplicações do mesmo. é divulgado um composto de pirazolpirimidina, um método de preparação para o mesmo e aplicações do mesmo. é fornecido na presente invenção o composto de pirazolpirimidina como representado pela fórmula (ii). o composto melhorou a atividade inibidora em relação à wee1 quinase.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201910579671 | 2019-06-28 | ||
PCT/CN2020/098611 WO2020259703A1 (zh) | 2019-06-28 | 2020-06-28 | 一种吡唑酮并嘧啶类化合物、其制备方法及应用 |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112021026618A2 true BR112021026618A2 (pt) | 2022-06-07 |
Family
ID=73888651
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112021026618A BR112021026618A2 (pt) | 2019-06-28 | 2020-06-28 | Composto de pirazolpirimidina, método de preparação do mesmo e aplicações do mesmo |
Country Status (13)
Country | Link |
---|---|
US (1) | US20220259210A1 (pt) |
EP (1) | EP3992193A4 (pt) |
JP (1) | JP2022538901A (pt) |
KR (1) | KR20220042127A (pt) |
CN (1) | CN112142747B (pt) |
AU (1) | AU2020306139A1 (pt) |
BR (1) | BR112021026618A2 (pt) |
CA (1) | CA3145344A1 (pt) |
CL (1) | CL2021003517A1 (pt) |
CO (1) | CO2022000748A2 (pt) |
IL (1) | IL289375A (pt) |
MX (1) | MX2021015572A (pt) |
WO (1) | WO2020259703A1 (pt) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN114591334B (zh) * | 2020-12-04 | 2023-10-20 | 山东轩竹医药科技有限公司 | 二氢吡唑并嘧啶酮衍生物 |
CN115197221A (zh) * | 2021-04-02 | 2022-10-18 | 轩竹生物科技股份有限公司 | 二氢吡唑并嘧啶酮类大环衍生物及其用途 |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2005534681A (ja) | 2002-07-15 | 2005-11-17 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | キナーゼ阻害剤としてのトキソフラビンの3−フラニル類似物 |
GB0420520D0 (en) * | 2004-09-15 | 2004-10-20 | Novartis Ag | Organic compounds |
TW200630090A (en) * | 2004-10-21 | 2006-09-01 | Vertex Pharma | Triazoles useful as inhibitors of protein kinases |
AU2006205851A1 (en) * | 2005-01-14 | 2006-07-20 | Janssen Pharmaceutica N.V. | 5-membered annelated heterocyclic pyrimidines as kinase inhibitors |
AR060635A1 (es) * | 2006-04-27 | 2008-07-02 | Banyu Pharma Co Ltd | Derivados de 1,2-dihidro-3h-pirazolo[3,4-d]pirimidin-3-ona, composiciones farmaceuticas que los comprenden y su uso en el tratamiento del cancer |
AU2008229147A1 (en) | 2007-03-20 | 2008-09-25 | Smithkline Beecham Corporation | Chemical compounds |
MX2009010047A (es) | 2007-03-20 | 2009-12-04 | Smithkline Beecham Corp | Compuestos quimicos. |
CA2745970A1 (en) | 2008-12-12 | 2010-06-17 | Msd K.K. | Dihydropyrimidopyrimidine derivative |
TW201035100A (en) * | 2008-12-19 | 2010-10-01 | Cephalon Inc | Pyrrolotriazines as ALK and JAK2 inhibitors |
WO2010098367A1 (en) | 2009-02-25 | 2010-09-02 | Banyu Pharmaceutical Co.,Ltd. | Pyrimidopyrimidoindazole derivative |
TW201105669A (en) * | 2009-07-30 | 2011-02-16 | Irm Llc | Compounds and compositions as Syk kinase inhibitors |
US10947238B2 (en) * | 2015-11-01 | 2021-03-16 | The Regents Of The University Of Colorado, A Body Corporate | Wee1 kinase inhibitors and methods of making and using the same |
GB201612092D0 (en) * | 2016-07-12 | 2016-08-24 | Almac Discovery Ltd | Pharmaceutical compounds |
CN110198943B (zh) * | 2017-01-23 | 2021-04-16 | 石家庄智康弘仁新药开发有限公司 | 作为Wee1抑制剂的1,2-二氢-3H-吡唑[3,4-d]嘧啶-3-酮衍生物 |
JP7203816B2 (ja) | 2017-08-01 | 2023-01-13 | リキュリウム アイピー ホールディングス リミテッド ライアビリティー カンパニー | 1,2-ジヒドロ-3H-ピラゾロ[3,4-d]ピリミジン-3-オン類似体 |
WO2019037678A1 (zh) | 2017-08-24 | 2019-02-28 | 上海迪诺医药科技有限公司 | 吡唑并[3,4-d]嘧啶-3-酮衍生物、其药物组合物及应用 |
WO2019074979A1 (en) * | 2017-10-09 | 2019-04-18 | Girafpharma, Llc | HETEROCYCLIC COMPOUNDS AND USES THEREOF |
CN109810111B (zh) * | 2017-11-20 | 2023-10-27 | 上海医药集团股份有限公司 | 一种吡唑酮并嘧啶类化合物、其制备方法及应用 |
WO2019165204A1 (en) * | 2018-02-23 | 2019-08-29 | Newave Pharmaceutical Inc. | 1,2-dihydro-3h-pyrazolo[3,4-d]pyrimidine-3-one compounds as inhibitors of wee-1 kinase |
-
2020
- 2020-06-28 EP EP20831765.1A patent/EP3992193A4/en active Pending
- 2020-06-28 CA CA3145344A patent/CA3145344A1/en active Pending
- 2020-06-28 US US17/622,579 patent/US20220259210A1/en active Pending
- 2020-06-28 BR BR112021026618A patent/BR112021026618A2/pt unknown
- 2020-06-28 AU AU2020306139A patent/AU2020306139A1/en active Pending
- 2020-06-28 WO PCT/CN2020/098611 patent/WO2020259703A1/zh unknown
- 2020-06-28 CN CN202010601527.5A patent/CN112142747B/zh active Active
- 2020-06-28 MX MX2021015572A patent/MX2021015572A/es unknown
- 2020-06-28 KR KR1020227002952A patent/KR20220042127A/ko unknown
- 2020-06-28 JP JP2021578117A patent/JP2022538901A/ja active Pending
-
2021
- 2021-12-26 IL IL289375A patent/IL289375A/en unknown
- 2021-12-28 CL CL2021003517A patent/CL2021003517A1/es unknown
-
2022
- 2022-01-27 CO CONC2022/0000748A patent/CO2022000748A2/es unknown
Also Published As
Publication number | Publication date |
---|---|
CA3145344A1 (en) | 2020-12-30 |
CN112142747B (zh) | 2024-03-01 |
EP3992193A1 (en) | 2022-05-04 |
AU2020306139A1 (en) | 2022-02-24 |
JP2022538901A (ja) | 2022-09-06 |
KR20220042127A (ko) | 2022-04-04 |
CL2021003517A1 (es) | 2022-08-19 |
WO2020259703A1 (zh) | 2020-12-30 |
CO2022000748A2 (es) | 2022-04-29 |
EP3992193A4 (en) | 2023-08-16 |
MX2021015572A (es) | 2022-04-06 |
US20220259210A1 (en) | 2022-08-18 |
CN112142747A (zh) | 2020-12-29 |
IL289375A (en) | 2022-02-01 |
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