UA95454C2 - Арил- і гетероарилзаміщені тетрагідробензазепіни і їх застосування для блокування зворотного захоплення норепінефрину, допаміну і серотоніну - Google Patents

Арил- і гетероарилзаміщені тетрагідробензазепіни і їх застосування для блокування зворотного захоплення норепінефрину, допаміну і серотоніну

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Publication number
UA95454C2
UA95454C2 UAA200801920A UAA200801920A UA95454C2 UA 95454 C2 UA95454 C2 UA 95454C2 UA A200801920 A UAA200801920 A UA A200801920A UA A200801920 A UAA200801920 A UA A200801920A UA 95454 C2 UA95454 C2 UA 95454C2
Authority
UA
Ukraine
Prior art keywords
heteroaryl
aryl
norepinephrine
serotonin
dopamine
Prior art date
Application number
UAA200801920A
Other languages
English (en)
Russian (ru)
Inventor
Брюс Ф. МОЛІНО
Шуан Лю
Аруна Самбандам
Пітер Р. Газзо
Мін Ху
Цунсян Чжа
Кассум Накро
Девід Д. Меннінг
Метью Л. Шервуд
Крістен Н. Флемінг
Вене Цуй
Річард Е. Олсон
Original Assignee
Амр Текнолоджи, Інк.
Брістоль-Мейєрз Сквібб Компані
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Амр Текнолоджи, Інк., Брістоль-Мейєрз Сквібб Компані filed Critical Амр Текнолоджи, Інк.
Publication of UA95454C2 publication Critical patent/UA95454C2/uk

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    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
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Abstract

Сполуки згідно із даним винаходом представлені наступними арил- і гетероарилзаміщеними похідними тетрагідробензазепіну і дигідробензазепіну, що мають формули І(А-Е) і формулу (II), у яких атом вуглецю, позначений *, знаходиться в конфігурації R або S, а замісники X і R1-R9 мають значення, визначені в описі, , .
UAA200801920A 2005-07-15 2006-07-17 Арил- і гетероарилзаміщені тетрагідробензазепіни і їх застосування для блокування зворотного захоплення норепінефрину, допаміну і серотоніну UA95454C2 (uk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US70005705P 2005-07-15 2005-07-15
PCT/US2006/027574 WO2007011820A2 (en) 2005-07-15 2006-07-17 Aryl-and heteroaryl-substituted tetrahydrobenzazepines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin

Publications (1)

Publication Number Publication Date
UA95454C2 true UA95454C2 (uk) 2011-08-10

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UAA200801920A UA95454C2 (uk) 2005-07-15 2006-07-17 Арил- і гетероарилзаміщені тетрагідробензазепіни і їх застосування для блокування зворотного захоплення норепінефрину, допаміну і серотоніну

Country Status (17)

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US (4) US7956050B2 (uk)
EP (1) EP1904069B1 (uk)
JP (2) JP5258561B2 (uk)
KR (3) KR20080044840A (uk)
CN (1) CN101495184A (uk)
AU (1) AU2006270071B2 (uk)
BR (1) BRPI0613403A2 (uk)
CA (1) CA2615403C (uk)
EA (1) EA019115B1 (uk)
GE (1) GEP20125566B (uk)
IL (3) IL188758A (uk)
MX (1) MX2008000717A (uk)
NZ (1) NZ565111A (uk)
PH (1) PH12014501033A1 (uk)
UA (1) UA95454C2 (uk)
WO (1) WO2007011820A2 (uk)
ZA (1) ZA200800440B (uk)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1778639B1 (en) 2004-07-15 2015-09-02 Albany Molecular Research, Inc. Aryl-and heteroaryl-substituted tetrahydroisoquinolines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin
EP2233470B1 (en) 2005-07-04 2011-12-07 High Point Pharmaceuticals, LLC Histamine H3 receptor antagonists
KR20080044840A (ko) 2005-07-15 2008-05-21 에이엠알 테크놀로지, 인크. 아릴- 및 헤테로아릴-치환된 테트라히드로벤자제핀, 및노르에피네프린, 도파민 및 세로토닌의 재흡수를 차단하기위한 용도
SG163547A1 (en) 2006-05-29 2010-08-30 High Point Pharmaceuticals Llc 3- (1, 3-benz0di0x0l-5-yl) -6- (4-cyclopropylpiperazin-1-yl) -pyridazine, its salts and solvates and its use as histamine h3 receptor antagonist
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