PL1893589T3 - PODSTAWIONE POCHODNE N-BENZO[D]IZOKSAZOL-3-ILOAMINY JAKO INHIBITORY RECEPTORÓW mGluR5, SEROTONINY (5-HT) I NORADRENALINY I ICH ZASTOSOWANIE DO WYTWARZANIA ŚRODKÓW LECZNICZYCH - Google Patents
PODSTAWIONE POCHODNE N-BENZO[D]IZOKSAZOL-3-ILOAMINY JAKO INHIBITORY RECEPTORÓW mGluR5, SEROTONINY (5-HT) I NORADRENALINY I ICH ZASTOSOWANIE DO WYTWARZANIA ŚRODKÓW LECZNICZYCHInfo
- Publication number
- PL1893589T3 PL1893589T3 PL06761974T PL06761974T PL1893589T3 PL 1893589 T3 PL1893589 T3 PL 1893589T3 PL 06761974 T PL06761974 T PL 06761974T PL 06761974 T PL06761974 T PL 06761974T PL 1893589 T3 PL1893589 T3 PL 1893589T3
- Authority
- PL
- Poland
- Prior art keywords
- isoxazol
- benzo
- substituted
- serotonine
- mglur5
- Prior art date
Links
- 239000003814 drug Substances 0.000 title abstract 2
- QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 title 2
- 239000003112 inhibitor Substances 0.000 title 1
- 229960002748 norepinephrine Drugs 0.000 title 1
- SFLSHLFXELFNJZ-UHFFFAOYSA-N norepinephrine Natural products NCC(O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-UHFFFAOYSA-N 0.000 title 1
- NLMVYUBGWZWUGB-UHFFFAOYSA-N 1,2-benzoxazol-3-amine Chemical class C1=CC=C2C(N)=NOC2=C1 NLMVYUBGWZWUGB-UHFFFAOYSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
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- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/20—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Pain & Pain Management (AREA)
- Anesthesiology (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Ophthalmology & Optometry (AREA)
- Pulmonology (AREA)
- Urology & Nephrology (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Rheumatology (AREA)
- Child & Adolescent Psychology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Nutrition Science (AREA)
- Otolaryngology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102005026194A DE102005026194A1 (de) | 2005-06-06 | 2005-06-06 | Substituierte N-Benzo[d]isoxazol-3-yl-amin-Derivate und deren Verwendung zur Herstellung von Arzneimitteln |
| PCT/EP2006/005356 WO2006131296A1 (de) | 2005-06-06 | 2006-06-06 | Substituierte n-benzo [d] isoxazol-3-yl-amin-derivative als inhibitoren von mglur5, serotonin- (5-ht) und noradrenalin rezeptoren und deren verwendung zur herstellung von arzneimitteln |
| EP06761974A EP1893589B1 (de) | 2005-06-06 | 2006-06-06 | Substituierte n-benzo [d] isoxazol-3-yl-amin-derivative als inhibitoren von mglur5, serotonin-(5-ht) und noradrenalin rezeptoren und deren verwendung zur herstellung von arzneimitteln |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL1893589T3 true PL1893589T3 (pl) | 2012-02-29 |
Family
ID=36792815
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL06761974T PL1893589T3 (pl) | 2005-06-06 | 2006-06-06 | PODSTAWIONE POCHODNE N-BENZO[D]IZOKSAZOL-3-ILOAMINY JAKO INHIBITORY RECEPTORÓW mGluR5, SEROTONINY (5-HT) I NORADRENALINY I ICH ZASTOSOWANIE DO WYTWARZANIA ŚRODKÓW LECZNICZYCH |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20080312301A1 (pl) |
| EP (1) | EP1893589B1 (pl) |
| JP (1) | JP2008542414A (pl) |
| AT (1) | ATE524451T1 (pl) |
| CA (1) | CA2610373A1 (pl) |
| CY (1) | CY1112449T1 (pl) |
| DE (1) | DE102005026194A1 (pl) |
| DK (1) | DK1893589T3 (pl) |
| ES (1) | ES2373684T3 (pl) |
| PL (1) | PL1893589T3 (pl) |
| PT (1) | PT1893589E (pl) |
| SI (1) | SI1893589T1 (pl) |
| WO (1) | WO2006131296A1 (pl) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102005038947A1 (de) * | 2005-05-18 | 2006-11-30 | Grünenthal GmbH | Substituierte Benzo[d]isoxazol-3-yl-amin-Verbindungen und deren Verwendung in Arzneimitteln |
| EP2170834B1 (en) * | 2007-07-16 | 2014-01-08 | AbbVie Inc. | Indazoles, benzisoxazoles and benzisothiazoles as inhibitors of protein kinases |
| CA2957884A1 (en) | 2014-08-13 | 2016-02-18 | Auckland Uniservices Limited | Inhibitors of tryptophan dioxygenases (ido1 and tdo) and their use in therapy |
| EP3350188B1 (en) | 2015-08-27 | 2024-03-13 | Auckland Uniservices Limited | Inhibitors of tryptophan dioxygenases (ido1 and tdo) and their use in therapy |
| WO2017160930A1 (en) * | 2016-03-16 | 2017-09-21 | Kalyra Pharmaceuticals, Inc. | Analgesic compounds |
| CN110117278B (zh) * | 2018-02-07 | 2022-07-19 | 石家庄以岭药业股份有限公司 | 烷氧基苯并五元(六元)杂环胺类化合物及其药物用途 |
| WO2022015938A1 (en) * | 2020-07-15 | 2022-01-20 | Ifm Due, Inc. | Compounds and compositions for treating conditions associated with sting activity |
| WO2022025636A1 (ko) * | 2020-07-29 | 2022-02-03 | 주식회사 비보존 | Mglur5 및 5-ht2a 수용체의 이중 조절제 및 이의 용도 |
| IL310724A (en) | 2021-08-10 | 2024-04-01 | Ifm Due Inc | COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF CONDITIONS ASSOCIATED WITH STING ACTIVITY |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5721377A (en) * | 1980-07-11 | 1982-02-04 | Shionogi & Co Ltd | 3-substituted-1,2-benzisoxazole derivative |
| US4322429A (en) * | 1980-09-16 | 1982-03-30 | Eli Lilly And Company | Isoxazolylbenzamides as insecticides |
| FR2654104B1 (fr) * | 1989-11-07 | 1992-01-03 | Adir | Nouveaux derives du 1,2-benzisoxazole, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent. |
| FR2701026B1 (fr) * | 1993-02-02 | 1995-03-31 | Adir | Nouveaux dérivés de l'indole, de l'indazole et du benzisoxazole, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent. |
| UA62015C2 (en) * | 1998-12-28 | 2003-12-15 | Pfizer Prod Inc | Benzoizoxazol derivatives, a pharmaceutical composition (variants) based thereon (variants) and a method for treatment (variants) |
| US6593349B2 (en) * | 2001-03-19 | 2003-07-15 | Icagen, Inc. | Bisarylamines as potassium channel openers |
| EP1427416A2 (en) * | 2001-09-13 | 2004-06-16 | Synta Pharmaceuticals Corporation | 3-glyoxlylamideindoles for treating cancer |
| KR100789567B1 (ko) * | 2001-11-06 | 2007-12-28 | 동화약품공업주식회사 | 3-아미도-1,2-벤조이소옥사졸 유도체, 그 염, 제조방법 및 용도 |
| GB0319150D0 (en) * | 2003-08-14 | 2003-09-17 | Glaxo Group Ltd | Novel compounds |
| KR20070026390A (ko) * | 2004-01-23 | 2007-03-08 | 암젠 인코포레이션 | 화합물 및 사용방법 |
| US20070197610A1 (en) * | 2004-03-16 | 2007-08-23 | Janssen Pharmaceutica N.V. | Benzisoxazoles |
| US7759337B2 (en) * | 2005-03-03 | 2010-07-20 | Amgen Inc. | Phthalazine compounds and methods of use |
-
2005
- 2005-06-06 DE DE102005026194A patent/DE102005026194A1/de not_active Withdrawn
-
2006
- 2006-06-06 US US11/916,613 patent/US20080312301A1/en not_active Abandoned
- 2006-06-06 ES ES06761974T patent/ES2373684T3/es active Active
- 2006-06-06 EP EP06761974A patent/EP1893589B1/de not_active Not-in-force
- 2006-06-06 PL PL06761974T patent/PL1893589T3/pl unknown
- 2006-06-06 SI SI200631193T patent/SI1893589T1/sl unknown
- 2006-06-06 CA CA002610373A patent/CA2610373A1/en not_active Abandoned
- 2006-06-06 AT AT06761974T patent/ATE524451T1/de active
- 2006-06-06 PT PT06761974T patent/PT1893589E/pt unknown
- 2006-06-06 WO PCT/EP2006/005356 patent/WO2006131296A1/de not_active Ceased
- 2006-06-06 JP JP2008515121A patent/JP2008542414A/ja not_active Ceased
- 2006-06-06 DK DK06761974.2T patent/DK1893589T3/da active
-
2011
- 2011-12-13 CY CY20111101238T patent/CY1112449T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP1893589A1 (de) | 2008-03-05 |
| US20080312301A1 (en) | 2008-12-18 |
| DE102005026194A1 (de) | 2006-12-07 |
| PT1893589E (pt) | 2012-01-02 |
| ATE524451T1 (de) | 2011-09-15 |
| CY1112449T1 (el) | 2015-12-09 |
| CA2610373A1 (en) | 2006-12-14 |
| DK1893589T3 (da) | 2012-01-16 |
| EP1893589B1 (de) | 2011-09-14 |
| SI1893589T1 (sl) | 2012-01-31 |
| ES2373684T3 (es) | 2012-02-07 |
| WO2006131296A1 (de) | 2006-12-14 |
| JP2008542414A (ja) | 2008-11-27 |
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