CY1112449T1 - Υποκατεστημενα ν-βενζο [d] ισοξαζολ-3-υλ-αμινο παραγωγα ως αναστολεις υποδοχεων mglur5, σεροτονινης-(5-ητ) και νοραδρεναλινης και η χρηση αυτων για την παραγωγη φαρμακων - Google Patents

Υποκατεστημενα ν-βενζο [d] ισοξαζολ-3-υλ-αμινο παραγωγα ως αναστολεις υποδοχεων mglur5, σεροτονινης-(5-ητ) και νοραδρεναλινης και η χρηση αυτων για την παραγωγη φαρμακων

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Publication number
CY1112449T1
CY1112449T1 CY20111101238T CY111101238T CY1112449T1 CY 1112449 T1 CY1112449 T1 CY 1112449T1 CY 20111101238 T CY20111101238 T CY 20111101238T CY 111101238 T CY111101238 T CY 111101238T CY 1112449 T1 CY1112449 T1 CY 1112449T1
Authority
CY
Cyprus
Prior art keywords
isoxazol
benzo
substituted
mglur5
nocturnal
Prior art date
Application number
CY20111101238T
Other languages
English (en)
Inventor
Beatrix Merla
Matthias Gerlach
Corinna Sundermann
Utz-Peter Jagusch
Hagen-Heinrich Hennies
Stefan Oberbörsch
Michael Haurand
Ruth Jostock
Melanie Reich
Original Assignee
Grünenthal GmbH
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Filing date
Publication date
Application filed by Grünenthal GmbH filed Critical Grünenthal GmbH
Publication of CY1112449T1 publication Critical patent/CY1112449T1/el

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

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Abstract

Η παρούσα εφεύρεση αφορά υποκατεστημένα Ν-βενζο[d]ισοξαζολ-3-υλ-αμινο παράγωγα του Τύπου (I), στον οποίο τα R1, R2, R3, R4 και R5 είναι όπως ορίζονται εις την αξίωση 1 και τη χρήση των ενώσεων αυτών για την παραγωγή φαρμάκων.
CY20111101238T 2005-06-06 2011-12-13 Υποκατεστημενα ν-βενζο [d] ισοξαζολ-3-υλ-αμινο παραγωγα ως αναστολεις υποδοχεων mglur5, σεροτονινης-(5-ητ) και νοραδρεναλινης και η χρηση αυτων για την παραγωγη φαρμακων CY1112449T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102005026194A DE102005026194A1 (de) 2005-06-06 2005-06-06 Substituierte N-Benzo[d]isoxazol-3-yl-amin-Derivate und deren Verwendung zur Herstellung von Arzneimitteln
EP06761974A EP1893589B1 (de) 2005-06-06 2006-06-06 Substituierte n-benzo [d] isoxazol-3-yl-amin-derivative als inhibitoren von mglur5, serotonin-(5-ht) und noradrenalin rezeptoren und deren verwendung zur herstellung von arzneimitteln

Publications (1)

Publication Number Publication Date
CY1112449T1 true CY1112449T1 (el) 2015-12-09

Family

ID=36792815

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20111101238T CY1112449T1 (el) 2005-06-06 2011-12-13 Υποκατεστημενα ν-βενζο [d] ισοξαζολ-3-υλ-αμινο παραγωγα ως αναστολεις υποδοχεων mglur5, σεροτονινης-(5-ητ) και νοραδρεναλινης και η χρηση αυτων για την παραγωγη φαρμακων

Country Status (13)

Country Link
US (1) US20080312301A1 (el)
EP (1) EP1893589B1 (el)
JP (1) JP2008542414A (el)
AT (1) ATE524451T1 (el)
CA (1) CA2610373A1 (el)
CY (1) CY1112449T1 (el)
DE (1) DE102005026194A1 (el)
DK (1) DK1893589T3 (el)
ES (1) ES2373684T3 (el)
PL (1) PL1893589T3 (el)
PT (1) PT1893589E (el)
SI (1) SI1893589T1 (el)
WO (1) WO2006131296A1 (el)

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DE102005038947A1 (de) * 2005-05-18 2006-11-30 Grünenthal GmbH Substituierte Benzo[d]isoxazol-3-yl-amin-Verbindungen und deren Verwendung in Arzneimitteln
EP2170834B1 (en) * 2007-07-16 2014-01-08 AbbVie Inc. Indazoles, benzisoxazoles and benzisothiazoles as inhibitors of protein kinases
WO2016024233A1 (en) 2014-08-13 2016-02-18 Auckland Uniservices Limited Inhibitors of tryptophan dioxygenases (ido1 and tdo) and their use in therapy
AU2016312848A1 (en) * 2015-08-27 2018-03-29 Auckland Uniservices Limited Inhibitors of tryptophan dioxygenases (IDO1 and TDO) and their use in therapy
WO2017160930A1 (en) * 2016-03-16 2017-09-21 Kalyra Pharmaceuticals, Inc. Analgesic compounds
CN110117278B (zh) * 2018-02-07 2022-07-19 石家庄以岭药业股份有限公司 烷氧基苯并五元(六元)杂环胺类化合物及其药物用途
US20230250088A1 (en) * 2020-07-15 2023-08-10 Ifm Due, Inc. Compounds and compositions for treating conditions associated with sting activity
CN116234552A (zh) * 2020-07-29 2023-06-06 (株)倍宝尊 mGluR5和5-HT2A受体的双重调节剂及其用途

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JPS5721377A (en) * 1980-07-11 1982-02-04 Shionogi & Co Ltd 3-substituted-1,2-benzisoxazole derivative
US4322429A (en) * 1980-09-16 1982-03-30 Eli Lilly And Company Isoxazolylbenzamides as insecticides
FR2654104B1 (fr) * 1989-11-07 1992-01-03 Adir Nouveaux derives du 1,2-benzisoxazole, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent.
FR2701026B1 (fr) * 1993-02-02 1995-03-31 Adir Nouveaux dérivés de l'indole, de l'indazole et du benzisoxazole, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.
UA62015C2 (en) * 1998-12-28 2003-12-15 Pfizer Prod Inc Benzoizoxazol derivatives, a pharmaceutical composition (variants) based thereon (variants) and a method for treatment (variants)
US6593349B2 (en) * 2001-03-19 2003-07-15 Icagen, Inc. Bisarylamines as potassium channel openers
WO2003022280A2 (en) * 2001-09-13 2003-03-20 Synta Pharmaceuticals Corp. 3-glyoxlylamideindoles for treating cancer
KR100789567B1 (ko) * 2001-11-06 2007-12-28 동화약품공업주식회사 3-아미도-1,2-벤조이소옥사졸 유도체, 그 염, 제조방법 및 용도
GB0319150D0 (en) * 2003-08-14 2003-09-17 Glaxo Group Ltd Novel compounds
TW200536851A (en) * 2004-01-23 2005-11-16 Amgen Inc Compounds and methods of use
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US7759337B2 (en) * 2005-03-03 2010-07-20 Amgen Inc. Phthalazine compounds and methods of use

Also Published As

Publication number Publication date
CA2610373A1 (en) 2006-12-14
DE102005026194A1 (de) 2006-12-07
ATE524451T1 (de) 2011-09-15
JP2008542414A (ja) 2008-11-27
ES2373684T3 (es) 2012-02-07
EP1893589B1 (de) 2011-09-14
WO2006131296A1 (de) 2006-12-14
EP1893589A1 (de) 2008-03-05
SI1893589T1 (sl) 2012-01-31
US20080312301A1 (en) 2008-12-18
DK1893589T3 (da) 2012-01-16
PL1893589T3 (pl) 2012-02-29
PT1893589E (pt) 2012-01-02

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