UA43342C2 - Фармацевтична композиція з ентеросолюбільним покриттям для орального введення, спосіб її одержання, спосіб інгібування секреції кислоти шлунком у ссавців і людини та спосіб лікування захворювань у ссавців і людини, що пов`язані з секрецією кислоти шлунком - Google Patents
Фармацевтична композиція з ентеросолюбільним покриттям для орального введення, спосіб її одержання, спосіб інгібування секреції кислоти шлунком у ссавців і людини та спосіб лікування захворювань у ссавців і людини, що пов`язані з секрецією кислоти шлункомInfo
- Publication number
- UA43342C2 UA43342C2 UA96010058A UA96010058A UA43342C2 UA 43342 C2 UA43342 C2 UA 43342C2 UA 96010058 A UA96010058 A UA 96010058A UA 96010058 A UA96010058 A UA 96010058A UA 43342 C2 UA43342 C2 UA 43342C2
- Authority
- UA
- Ukraine
- Prior art keywords
- mammals
- stomach
- human
- acid
- secretion
- Prior art date
Links
- 239000011248 coating agent Substances 0.000 title abstract 4
- 238000000576 coating method Methods 0.000 title abstract 4
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 238000000034 method Methods 0.000 title 3
- 241000124008 Mammalia Species 0.000 title 2
- 239000002253 acid Substances 0.000 title 2
- 230000028327 secretion Effects 0.000 title 2
- 210000002784 stomach Anatomy 0.000 title 2
- 201000010099 disease Diseases 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- 230000005764 inhibitory process Effects 0.000 title 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 abstract 1
- 238000002955 isolation Methods 0.000 abstract 1
- 159000000003 magnesium salts Chemical class 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 239000000843 powder Substances 0.000 abstract 1
- 210000000813 small intestine Anatomy 0.000 abstract 1
- 238000009498 subcoating Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2886—Dragees; Coated pills or tablets, e.g. with film or compression coating having two or more different drug-free coatings; Tablets of the type inert core-drug layer-inactive layer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicinal Preparation (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Фармацевтична композиція з ентеросолюбільним покриттям для перорального введення містить у якості активного інгредієнту магнієву сіль омепразолу, ступень кристалічності якої складає більше 70%, що визначено порошковою рентгенографією. На матеріал ядра нанесено(і) шар(и) субпокриття, що відокремлює матеріал ядра від ентеросолюбільногоо покриття. Товща ентеросолюбільного покриття несуттєво впливає на виділення омепразолу у водні розчини зі значеннями рН, які переважно мають місце у тонкій кишці.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE19939302395A SE9302395D0 (sv) | 1993-07-09 | 1993-07-09 | New pharmaceutical formulation |
PCT/SE1994/000681 WO1995001783A1 (en) | 1993-07-09 | 1994-07-08 | New pharmaceutical formulation |
Publications (1)
Publication Number | Publication Date |
---|---|
UA43342C2 true UA43342C2 (uk) | 2001-12-17 |
Family
ID=20390587
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UA96010058A UA43342C2 (uk) | 1993-07-09 | 1994-07-08 | Фармацевтична композиція з ентеросолюбільним покриттям для орального введення, спосіб її одержання, спосіб інгібування секреції кислоти шлунком у ссавців і людини та спосіб лікування захворювань у ссавців і людини, що пов`язані з секрецією кислоти шлунком |
Country Status (40)
Country | Link |
---|---|
US (1) | US5690960A (uk) |
EP (1) | EP0706378B1 (uk) |
JP (1) | JP3665334B2 (uk) |
KR (1) | KR100350203B1 (uk) |
CN (1) | CN1126946A (uk) |
AT (1) | ATE231719T1 (uk) |
AU (1) | AU681686B2 (uk) |
BR (1) | BR9406941A (uk) |
CA (1) | CA2166483C (uk) |
CZ (1) | CZ290323B6 (uk) |
DE (1) | DE69432076T2 (uk) |
DK (1) | DK0706378T3 (uk) |
DZ (1) | DZ1794A1 (uk) |
EE (1) | EE03148B1 (uk) |
EG (1) | EG22373A (uk) |
ES (1) | ES2191682T3 (uk) |
FI (1) | FI114008B (uk) |
HK (1) | HK1008299A1 (uk) |
HR (1) | HRP940386B1 (uk) |
HU (1) | HU226779B1 (uk) |
IL (1) | IL110189A0 (uk) |
IS (1) | IS2034B (uk) |
LV (1) | LV13140B (uk) |
MA (1) | MA23258A1 (uk) |
MX (1) | MX9405219A (uk) |
MY (1) | MY128809A (uk) |
NO (1) | NO315146B1 (uk) |
NZ (1) | NZ268694A (uk) |
PL (1) | PL175210B1 (uk) |
RU (1) | RU2138254C9 (uk) |
SA (1) | SA94150057B1 (uk) |
SE (1) | SE9302395D0 (uk) |
SG (1) | SG52365A1 (uk) |
SI (1) | SI0706378T1 (uk) |
SK (1) | SK281105B6 (uk) |
TN (1) | TNSN94078A1 (uk) |
UA (1) | UA43342C2 (uk) |
WO (1) | WO1995001783A1 (uk) |
YU (1) | YU49199B (uk) |
ZA (1) | ZA944934B (uk) |
Families Citing this family (98)
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US6875872B1 (en) | 1993-05-28 | 2005-04-05 | Astrazeneca | Compounds |
SE9301830D0 (sv) * | 1993-05-28 | 1993-05-28 | Ab Astra | New compounds |
SE9302395D0 (sv) * | 1993-07-09 | 1993-07-09 | Ab Astra | New pharmaceutical formulation |
SE9402431D0 (sv) * | 1994-07-08 | 1994-07-08 | Astra Ab | New tablet formulation |
AU695966B2 (en) * | 1994-07-08 | 1998-08-27 | Astrazeneca Ab | Multiple unit tableted dosage form I |
HUT78132A (hu) * | 1994-07-08 | 2000-06-28 | Astra Aktiebolag | Omeprazol magnéziumsóját tartalmazó új orális gyógyszerforma |
SE9500478D0 (sv) * | 1995-02-09 | 1995-02-09 | Astra Ab | New pharmaceutical formulation and process |
CR5278A (es) * | 1995-03-24 | 1996-07-04 | Lilly Co Eli | Formulacion oral de 2-metil-tieno-benzodiacepina |
US5945124A (en) * | 1995-07-05 | 1999-08-31 | Byk Gulden Chemische Fabrik Gmbh | Oral pharmaceutical composition with delayed release of active ingredient for pantoprazole |
US6645988B2 (en) | 1996-01-04 | 2003-11-11 | Curators Of The University Of Missouri | Substituted benzimidazole dosage forms and method of using same |
US6489346B1 (en) | 1996-01-04 | 2002-12-03 | The Curators Of The University Of Missouri | Substituted benzimidazole dosage forms and method of using same |
US5840737A (en) | 1996-01-04 | 1998-11-24 | The Curators Of The University Of Missouri | Omeprazole solution and method for using same |
US6699885B2 (en) | 1996-01-04 | 2004-03-02 | The Curators Of The University Of Missouri | Substituted benzimidazole dosage forms and methods of using same |
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SE508669C2 (sv) * | 1996-04-26 | 1998-10-26 | Astra Ab | Nytt förfarande |
DE19626045C2 (de) * | 1996-06-28 | 1998-12-03 | Klinge Co Chem Pharm Fab | Stabile Arzneiform zur oralen Verabreichung, welche Omeprazol als aktiven Wirkstoff enthält, sowie Verfahren zur Herstellung derselben |
US6623759B2 (en) | 1996-06-28 | 2003-09-23 | Astrazeneca Ab | Stable drug form for oral administration with benzimidazole derivatives as active ingredient and process for the preparation thereof |
BR9713215A (pt) * | 1996-09-24 | 2000-04-04 | Lilly Co Eli | Formulação de partìcula revestida |
TW385306B (en) * | 1996-11-14 | 2000-03-21 | Takeda Chemical Industries Ltd | Method for producing crystals of benzimidazole derivatives |
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SE9702000D0 (sv) * | 1997-05-28 | 1997-05-28 | Astra Ab | New pharmaceutical formulation |
SE510650C2 (sv) | 1997-05-30 | 1999-06-14 | Astra Ab | Ny förening |
US6747155B2 (en) | 1997-05-30 | 2004-06-08 | Astrazeneca Ab | Process |
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SE7804231L (sv) * | 1978-04-14 | 1979-10-15 | Haessle Ab | Magsyrasekretionsmedel |
SE8301182D0 (sv) * | 1983-03-04 | 1983-03-04 | Haessle Ab | Novel compounds |
GB2189698A (en) * | 1986-04-30 | 1987-11-04 | Haessle Ab | Coated omeprazole tablets |
JPH0768125B2 (ja) * | 1988-05-18 | 1995-07-26 | エーザイ株式会社 | 酸不安定化合物の内服用製剤 |
SE9302395D0 (sv) * | 1993-07-09 | 1993-07-09 | Ab Astra | New pharmaceutical formulation |
SE9302396D0 (sv) * | 1993-07-09 | 1993-07-09 | Ab Astra | A novel compound form |
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