TW438794B - New benzimidazole derivatives with antihistaminic activity - Google Patents

New benzimidazole derivatives with antihistaminic activity Download PDF

Info

Publication number
TW438794B
TW438794B TW086110371A TW86110371A TW438794B TW 438794 B TW438794 B TW 438794B TW 086110371 A TW086110371 A TW 086110371A TW 86110371 A TW86110371 A TW 86110371A TW 438794 B TW438794 B TW 438794B
Authority
TW
Taiwan
Prior art keywords
ethyl
compound
scope
patent application
dimethyl
Prior art date
Application number
TW086110371A
Other languages
English (en)
Chinese (zh)
Inventor
Aurelio Orjales
Victor Rubio
Maravillas Bordell
Original Assignee
Espanola Prod Quimicos
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Espanola Prod Quimicos filed Critical Espanola Prod Quimicos
Application granted granted Critical
Publication of TW438794B publication Critical patent/TW438794B/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pulmonology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
TW086110371A 1996-06-04 1997-07-22 New benzimidazole derivatives with antihistaminic activity TW438794B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES09601236A ES2124167B1 (es) 1996-06-04 1996-06-04 Nuevos derivados del bencimidazol con actividad antihistaminica.

Publications (1)

Publication Number Publication Date
TW438794B true TW438794B (en) 2001-06-07

Family

ID=8295035

Family Applications (1)

Application Number Title Priority Date Filing Date
TW086110371A TW438794B (en) 1996-06-04 1997-07-22 New benzimidazole derivatives with antihistaminic activity

Country Status (27)

Country Link
US (1) US5877187A (2)
EP (1) EP0818454B1 (2)
JP (1) JP4218991B2 (2)
CN (1) CN1105716C (2)
AR (1) AR008386A1 (2)
AT (1) ATE264317T1 (2)
AU (1) AU725700B2 (2)
BR (1) BR9703276A (2)
CA (1) CA2206754C (2)
CZ (1) CZ289278B6 (2)
DE (2) DE69728608T2 (2)
DK (1) DK0818454T3 (2)
ES (1) ES2124167B1 (2)
FR (1) FR11C0023I2 (2)
HR (1) HRP970307B1 (2)
HU (1) HU227598B1 (2)
IN (1) IN186319B (2)
LU (1) LU91798I2 (2)
MX (1) MXPA97004127A (2)
NO (2) NO313195B1 (2)
PL (1) PL188908B1 (2)
PT (1) PT818454E (2)
RU (1) RU2182150C2 (2)
SI (1) SI0818454T1 (2)
TR (1) TR199700464A3 (2)
TW (1) TW438794B (2)
ZA (1) ZA974893B (2)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20010053282A (ko) 1998-07-01 2001-06-25 다케다 야쿠힌 고교 가부시키가이샤 레티노이드-관련 수용체 기능 조절제
TR200101498T2 (tr) 1998-11-27 2001-11-21 Basf Aktiengesellschaft İkameli benzimidazoller ve parp inhibitörleri olarak kullanımları
ES2151442B1 (es) * 1999-01-11 2001-07-01 Espanola Prod Quimicos Nuevo derivado del bencenoetanol.
US6826561B2 (en) 2000-05-22 2004-11-30 Broadcom Corporation Method and apparatus for performing a binary search on an expanded tree
RU2288917C2 (ru) * 2002-04-19 2006-12-10 Фаэс Фарма, С.А. Полиморф 4-[2-[4-[1-(2-этоксиэтил)-1h-бензимидазол-2-ил]-1-пиперидинил]этил]-альфа, альфа-диметилбензолуксусной кислоты, способ его получения, фармацевтический препарат на его основе и его применение
SI1505066T1 (sl) * 2002-04-19 2007-04-30 Faes Farma Sa Polimorf 4-(2-(4-(1-(2-etoksietil)-1h-benzimidazol-2-il) -1-piperidinil)-alfa, alfa-dimetil-benzenocetne kisline
US7727992B2 (en) * 2002-06-13 2010-06-01 Vertex Pharmaceuticals Incorporated Gyrase inhibitors and uses thereof
US20070188330A1 (en) * 2006-01-24 2007-08-16 Morhard Robert C System and method for detecting, monitoring, tracking and identifying explosive materials using ID marks
US7247623B2 (en) * 2005-08-19 2007-07-24 Inspire Pharmaceuticals, Inc. Method of treating dry eye disease with non-drying antihistamines
WO2009102155A2 (en) * 2008-02-12 2009-08-20 Yuhan Corporation Process for preparation of 2-methyl-2´-phenylpropionic acid derivatives and novel intermediate compounds
JP2010013472A (ja) * 2009-09-09 2010-01-21 Faes Farma Sa ４−［２−［１−（２−エトキシエチル）−１Ｈ−ベンズイミダゾール−２−イル］−１−ピペリジニル］エチル］−α，α−ジメチルベンゼノ酢酸の多形体
CN102675101B (zh) * 2012-05-16 2014-01-29 王蕾 2-(4-卤乙基)苯基-2-甲基丙酸酯的制备方法及合成比拉斯汀的方法
CZ307500B6 (cs) 2012-08-15 2018-10-24 Zentiva, K.S. Způsob přípravy derivátu 2-methyl-2´-fenylpropionové kyseliny využívající nové intermediáty
CN105209122B (zh) * 2013-03-15 2018-07-17 赫尔克里士公司 组合物和制备具有提高的沉积性能的个人护理组合物的方法
CN103214454A (zh) * 2013-03-30 2013-07-24 北京万全德众医药生物技术有限公司 一种比拉斯汀晶型及制备方法
CN103214455B (zh) * 2013-03-30 2018-08-31 北京万全德众医药生物技术有限公司 一种比拉斯汀的制备方法
WO2014188453A2 (en) * 2013-05-24 2014-11-27 Msn Laboratories Private Limited Novel process for the preparation of 2-[4-(2-{4-[1-(2-ethoxyethyl)-1h-benzimidazol-2-yl]-1-piperidinyl}ethyl) phenyl]-2-methylpropanoic acid
CN103351380B (zh) * 2013-06-30 2019-01-22 北京万全德众医药生物技术有限公司 一种制备比拉斯汀的方法
CN104447683A (zh) * 2013-09-12 2015-03-25 天津市汉康医药生物技术有限公司 一种稳定的比拉斯汀化合物
CN103896915A (zh) * 2014-04-01 2014-07-02 中国药科大学 苯并咪唑类衍生物、其制备方法及其在医药上的应用
EP3040334A1 (en) 2014-12-29 2016-07-06 Faes Farma, S.A. New benzimidazole derivatives as antihistamine agents
CN106349214B (zh) * 2015-07-13 2020-11-03 南京长澳医药科技有限公司 一种比拉斯汀杂质的制备方法
ES2600827B9 (es) * 2015-07-24 2018-03-28 Urquima, S.A Formas cristalinas de bilastina y procedimientos para su preparación
CN105272977A (zh) * 2015-09-19 2016-01-27 万全万特制药江苏有限公司 一种制备比拉斯汀中间体的方法
EP3170816A1 (en) 2015-11-20 2017-05-24 Faes Farma, S.A. Supersaturated compositions of benzimidazole compounds
EP3170817A1 (en) 2015-11-20 2017-05-24 Faes Farma, S.A. Co-crystals of benzimidazole compounds
WO2017167949A1 (en) 2016-04-01 2017-10-05 Krka, D.D., Novo Mesto Crystalline forms of bilastine
WO2017191651A1 (en) * 2016-05-05 2017-11-09 Msn Laboratories Private Limited, R & D Center Solid state forms of 2-[4-(2-{4-[1-(2-ethoxyethyl)-1h-benzimidazol-2-yl]-1-piperidinyl}ethyl)phenyl]-2-methylpropanoic acid and process for preparation thereof
CN107365298A (zh) * 2017-03-14 2017-11-21 罗欣生物科技（上海）有限公司 一种2‑甲基‑2’‑苯基丙酸衍生物的制备方法
CN109456316A (zh) * 2017-09-06 2019-03-12 万全万特制药江苏有限公司 一种比拉斯汀杂质的制备方法
EP3453384B1 (en) 2017-09-07 2020-05-27 Alfred E. Tiefenbacher (GmbH & Co. KG) Pharmaceutical tablet composition comprising bilastine
BR112020007569A2 (pt) 2017-10-16 2020-09-24 Faes Farma, S.A. composições aquosas de bilastina
EP3470062B1 (en) 2017-12-18 2020-10-28 Alfred E. Tiefenbacher (GmbH & Co. KG) Pharmaceutical tablet composition comprising bilastine polymorphic form 3 and magnesium aluminometasilicate
ES2773756R1 (es) 2017-12-18 2021-04-12 Tiefenbacher Alfred E Gmbh & Co Kg Composición farmacéutica en comprimido que comprende la forma 3 de bilastina y una carga soluble en agua
WO2019141563A1 (en) 2018-01-18 2019-07-25 Faes Farma, S.A. Ophthalmic compositions comprising bilastine, a beta-cyclodextrin and at least one gelling agent
CN109081827A (zh) * 2018-11-06 2018-12-25 北京天弘天达医药科技股份有限公司 一种比拉斯汀的制备方法及应用
EP3725298A1 (en) 2019-04-16 2020-10-21 Faes Farma, S.A. Stable and preserved pharmaceutical compositions of bilastine
PE20231844A1 (es) 2020-07-30 2023-11-21 Faes Farma Sa Sistema de liberacion de farmacos descongestivos y bilastina
CN112110893A (zh) * 2020-10-28 2020-12-22 山东齐环医药科技有限公司 一种比拉斯汀的制备方法
EP4247331B1 (en) 2020-11-18 2025-10-08 BioPharma Synergies, S. L. Orodispersible powder composition comprising an antihistamine compound
CA3200779A1 (en) 2020-12-23 2022-06-30 Strusi ORAZIO LUCA A non-micronized bilastine composition
JP2025508704A (ja) 2022-02-17 2025-04-10 ファエス・ファルマ・ソシエダッド・アノニマ １日１回非経口投与のためのビラスチン組成物
WO2024224326A1 (en) * 2023-04-27 2024-10-31 Leiutis Pharmaceuticals Llp Liquid parenteral formulations of bilastine
WO2024224308A1 (en) * 2023-04-27 2024-10-31 Leiutis Pharmaceuticals Llp Liquid parenteral formulations of bilastine free of cyclodextrins

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8904174D0 (en) * 1989-02-23 1989-04-05 British Bio Technology Compounds
EP0525129A4 (en) * 1990-04-13 1993-03-24 Smith-Kline Beecham Corporation Substituted benzimidazoles
ES2048109B1 (es) * 1992-07-20 1994-12-16 Espanola Prod Quimicos Procedimiento de preparacion de nuevos derivados piperidicos del bencimidazol.
EP1214937B1 (en) * 1992-08-03 2007-05-30 Sepracor Inc. Terfenadine carboxylate and the treatment of dermal irritation
CA2166059C (en) * 1993-06-25 2005-08-16 Richard Carl Krauss Novel intermediates for the preparation of antihistaminic 4-diphenylmethyl/diphenylmethoxy piperidine derivatives

Also Published As

Publication number Publication date
FR11C0023I1 (2) 2011-08-19
HRP970307B1 (en) 2002-02-28
IN186319B (2) 2001-08-04
HU227598B1 (en) 2011-09-28
JPH1059961A (ja) 1998-03-03
NO2011008I2 (no) 2012-05-14
EP0818454A1 (en) 1998-01-14
CA2206754A1 (en) 1997-12-04
TR199700464A2 (xx) 1997-12-21
CZ289278B6 (cs) 2001-12-12
DE122011000006I1 (de) 2011-06-16
ES2124167A1 (es) 1999-01-16
PL188908B1 (pl) 2005-05-31
NO2011008I1 (no) 2011-06-06
BR9703276A (pt) 2004-08-17
MXPA97004127A (es) 2005-07-25
ZA974893B (en) 1997-12-30
CN1176964A (zh) 1998-03-25
DK0818454T3 (da) 2004-07-12
HUP9700997A1 (hu) 1999-09-28
CZ172397A3 (en) 1997-12-17
NO972525L (no) 1997-12-05
CA2206754C (en) 2007-01-23
PT818454E (pt) 2004-08-31
US5877187A (en) 1999-03-02
PL320358A1 (en) 1997-12-08
AR008386A1 (es) 2000-01-19
ES2124167B1 (es) 1999-09-16
RU2182150C2 (ru) 2002-05-10
CN1105716C (zh) 2003-04-16
SI0818454T1 (en) 2004-08-31
EP0818454B1 (en) 2004-04-14
AU2467297A (en) 1997-12-11
AU725700B2 (en) 2000-10-19
LU91798I2 (fr) 2011-05-23
NO972525D0 (no) 1997-06-03
NO313195B1 (no) 2002-08-26
ATE264317T1 (de) 2004-04-15
FR11C0023I2 (fr) 2012-03-16
TR199700464A3 (tr) 1997-12-21
HRP970307A2 (en) 1998-04-30
HU9700997D0 (en) 1997-07-28
DE69728608D1 (de) 2004-05-19
JP4218991B2 (ja) 2009-02-04
DE69728608T2 (de) 2005-04-21

Similar Documents

Publication Publication Date Title
TW438794B (en) New benzimidazole derivatives with antihistaminic activity
JP2944221B2 (ja) 新規複素環式化合物
JP4792025B2 (ja) ５−ヒドロキシインドール−３−カルボン酸エステル類誘導体およびその用途
JPH07291964A (ja) 新規ベンズイミダゾ−ルのピペリジン誘導体
JPH08508289A (ja) 抗精神病ベンゾイミダゾール誘導体
US6066632A (en) Heterocyclic compounds
US6054458A (en) Heterocyclic compounds
BR112014003245B1 (pt) Composto de ácido n-[5-(aminosulfonil)-4-metil-1,3-tiazol-2-il]-n-metil-2-[4-(2-piridinil)-fenil] acetamida metanossulfônico monohidratado cristalino, método para a sintetização do mesmo, e composição farmacêutica contendo o mesmo
JP2010024243A (ja) 緑内障および近視を処置するためのベンゾ［ｇ］キノリン誘導体
JP2010095550A (ja) キノリン誘導体
JP4076234B2 (ja) テトラヒドロベンズインドール化合物
FI91748C (fi) Menetelmä terapeuttisesti käyttökelpoisten kinolinonijohdannaisten valmistamiseksi
JPH07502268A (ja) 化学化合物、それらの製法および使用
JP2825652B2 (ja) ４−［（２−ベンゾチアゾリル）メチルアミノ］−α−［（３，４−ジフルオロフェノキシ）メチル］−１−ピペリジンエタノール
JPH08510263A (ja) ピペリジン誘導体、それらの製造および使用
DE60130691T2 (de) Indolderivate zur Behandlung von Erkrankungen des Zentralnervensystems
JPWO2002030896A1 (ja) ２，２−ジフェニルブタンアミド誘導体及びこれを含有する医薬
JP5165578B2 (ja) イソキノリンおよびベンゾ［ｈ］イソキノリン誘導体、調製およびヒスタミンｈ３受容体のアンタゴニストとしてのこの治療上の使用
JP2883970B2 (ja) 新規１，４−（ジフェニルアルキル）ピペラジン誘導体
RU2382037C2 (ru) Новые пиперидинзамещенные индолы или их гетеропроизводные
TW378209B (en) Benzo[g]quinoline derivatives, their preparation and the pharmaceutical composition containing them
KR100494448B1 (ko) 항히스타민활성을가지는신규한벤조이미다졸유도체
JPH10503214A (ja) アミノメチル アリール化合物；ドーパミンレセプター亜型選択性リガンド
JPH08510264A (ja) プソラレン誘導体、それらの製造および使用
DK146763B (da) Analogifremgangsmaade til fremstilling af 1-substituerede 4-(1,2-diphenylethyl)piperazinderivater

Legal Events

Date Code Title Description
GD4A Issue of patent certificate for granted invention patent
MK4A Expiration of patent term of an invention patent
MK4A Expiration of patent term of an invention patent