TR199901953T2 - Ftalazin ile angiogenez inhibe edici aktivite. - Google Patents

Ftalazin ile angiogenez inhibe edici aktivite.

Info

Publication number
TR199901953T2
TR199901953T2 TR1999/01953T TR9901953T TR199901953T2 TR 199901953 T2 TR199901953 T2 TR 199901953T2 TR 1999/01953 T TR1999/01953 T TR 1999/01953T TR 9901953 T TR9901953 T TR 9901953T TR 199901953 T2 TR199901953 T2 TR 199901953T2
Authority
TR
Turkey
Prior art keywords
phthalazine
angiogenesis
formula
inhibiting activity
bridge
Prior art date
Application number
TR1999/01953T
Other languages
English (en)
Inventor
Bold Guido
Frei J�Rg
Traxler Peter
Altmann Karl-Heinz
Mett Helmut
Raymond Stover David
Wood Jeanette
Original Assignee
Novartis Ag.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag. filed Critical Novartis Ag.
Publication of TR199901953T2 publication Critical patent/TR199901953T2/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Bulus formül (I) bilesikleri ile ilgilidir; içerisinde r 0-2' dir; n 0-2' dir; m 0-4' dür; R1 ile R2 (i) her durumda düsük alkildir, veya (ii) birlikte alt formül (I*) içinde bir köprü olustururlar; veya (iii) birlikte alt formül (I*) içinde bir köprü olustururlar; içerisinde T1,T2,T3 ve T4 zincir üyelerinden bir ya da iki tanesi nitrojen olarak bulunur ve kalanlar her durumda CH' dir; A, B, D ve E N veya CH'dir; içerisinde bu radikallerden iki tanesinden daha fazlasi N degildir; Gdüsük alkilen, asiloksi-veya hidroksi-düsük alkilen, -CH2-O-,-CH2-S-,-CH2-NH-, oksa, tia veya imino olarak bulunur; Q metildir; R H veya düsük alkildir.
TR1999/01953T 1997-02-13 1998-02-11 Ftalazin ile angiogenez inhibe edici aktivite. TR199901953T2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH31597 1997-02-13

Publications (1)

Publication Number Publication Date
TR199901953T2 true TR199901953T2 (tr) 1999-10-21

Family

ID=4184213

Family Applications (1)

Application Number Title Priority Date Filing Date
TR1999/01953T TR199901953T2 (tr) 1997-02-13 1998-02-11 Ftalazin ile angiogenez inhibe edici aktivite.

Country Status (32)

Country Link
US (3) US6258812B1 (tr)
EP (1) EP0970070B1 (tr)
JP (1) JP3544675B2 (tr)
KR (1) KR100441362B1 (tr)
CN (1) CN1251097B (tr)
AR (1) AR011135A1 (tr)
AT (1) ATE278686T1 (tr)
AU (1) AU731852B2 (tr)
BR (1) BR9807685B1 (tr)
CA (1) CA2281721C (tr)
CO (1) CO4950519A1 (tr)
CY (1) CY2550B1 (tr)
CZ (1) CZ297534B6 (tr)
DE (1) DE69826841T2 (tr)
DK (1) DK0970070T3 (tr)
ES (1) ES2234097T3 (tr)
HU (1) HU227972B1 (tr)
ID (1) ID23698A (tr)
IL (1) IL131273A0 (tr)
MY (1) MY128645A (tr)
NO (1) NO317367B1 (tr)
NZ (1) NZ337064A (tr)
PE (1) PE52499A1 (tr)
PL (1) PL197371B1 (tr)
PT (1) PT970070E (tr)
RU (1) RU2207132C2 (tr)
SI (1) SI0970070T1 (tr)
SK (1) SK285757B6 (tr)
TR (1) TR199901953T2 (tr)
TW (1) TWI250151B (tr)
WO (1) WO1998035958A1 (tr)
ZA (1) ZA981155B (tr)

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