ATE203534T1 - Angiogenesis hemmende pyridazinamine - Google Patents

Angiogenesis hemmende pyridazinamine

Info

Publication number
ATE203534T1
ATE203534T1 AT97901059T AT97901059T ATE203534T1 AT E203534 T1 ATE203534 T1 AT E203534T1 AT 97901059 T AT97901059 T AT 97901059T AT 97901059 T AT97901059 T AT 97901059T AT E203534 T1 ATE203534 T1 AT E203534T1
Authority
AT
Austria
Prior art keywords
6alkyl
alk
amino
6alkyloxy
hydrogen
Prior art date
Application number
AT97901059T
Other languages
English (en)
Inventor
Raymond Antoine Stokbroekx
Der Aa Marcel Jozef Maria Van
Marc Willems
Lieven Meerpoel
Marcel Gerebernus Maria Luyckx
Robert W Tuman
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Application granted granted Critical
Publication of ATE203534T1 publication Critical patent/ATE203534T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
AT97901059T 1996-01-15 1997-01-14 Angiogenesis hemmende pyridazinamine ATE203534T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP96200085 1996-01-15
PCT/EP1997/000201 WO1997026258A1 (en) 1996-01-15 1997-01-14 Angiogenesis inhibiting pyridazinamines

Publications (1)

Publication Number Publication Date
ATE203534T1 true ATE203534T1 (de) 2001-08-15

Family

ID=8223585

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97901059T ATE203534T1 (de) 1996-01-15 1997-01-14 Angiogenesis hemmende pyridazinamine

Country Status (21)

Country Link
US (1) US5985878A (de)
EP (1) EP0876366B1 (de)
JP (1) JP4169368B2 (de)
KR (1) KR100443893B1 (de)
CN (1) CN1104430C (de)
AT (1) ATE203534T1 (de)
AU (1) AU717744B2 (de)
CA (1) CA2237273C (de)
DE (1) DE69705819T2 (de)
DK (1) DK0876366T3 (de)
ES (1) ES2162235T3 (de)
GR (1) GR3036900T3 (de)
IL (1) IL124461A (de)
MY (1) MY117098A (de)
NO (1) NO309653B1 (de)
NZ (1) NZ326354A (de)
PT (1) PT876366E (de)
SI (1) SI0876366T1 (de)
TW (1) TW480256B (de)
WO (1) WO1997026258A1 (de)
ZA (1) ZA97288B (de)

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US8507490B2 (en) 2008-11-17 2013-08-13 Eli Lilly And Company Tetrasubstituted pyridazine hedgehog pathway antagonists
BRPI0921777A2 (pt) 2008-11-17 2016-01-12 Lilly Co Eli antagonistas da via hedgehog de piridazina tetrassubstituída
AR077014A1 (es) 2009-06-19 2011-07-27 Lilly Co Eli Compuesto derivado de ftalazina 1,4-disustituida, composicion farmaceutica que lo comprende y uso para preparar un medicamento util para el tratamiento de cancer
WO2011002067A1 (ja) * 2009-07-02 2011-01-06 武田薬品工業株式会社 複素環化合物およびその用途
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LT3762368T (lt) 2018-03-08 2022-06-10 Incyte Corporation Aminopirazindiolio junginiai, kaip pi3k-γ inhibitoriai
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Also Published As

Publication number Publication date
DE69705819D1 (de) 2001-08-30
DE69705819T2 (de) 2002-04-11
SI0876366T1 (en) 2001-12-31
US5985878A (en) 1999-11-16
NO982037L (no) 1998-09-15
CA2237273A1 (en) 1997-07-24
EP0876366B1 (de) 2001-07-25
ES2162235T3 (es) 2001-12-16
JP4169368B2 (ja) 2008-10-22
KR100443893B1 (ko) 2004-10-15
EP0876366A2 (de) 1998-11-11
WO1997026258A1 (en) 1997-07-24
DK0876366T3 (da) 2001-11-05
GR3036900T3 (en) 2002-01-31
KR19990067654A (ko) 1999-08-25
ZA97288B (en) 1998-07-14
MY117098A (en) 2004-05-31
AU717744B2 (en) 2000-03-30
CN1104430C (zh) 2003-04-02
NO982037D0 (no) 1998-05-05
IL124461A (en) 2000-07-26
NO309653B1 (no) 2001-03-05
PT876366E (pt) 2002-01-30
TW480256B (en) 2002-03-21
JP2000503014A (ja) 2000-03-14
CA2237273C (en) 2009-01-13
AU1443997A (en) 1997-08-11
CN1208415A (zh) 1999-02-17
IL124461A0 (en) 1998-12-06
NZ326354A (en) 1999-05-28

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Legal Events

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UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee